Theresa A Shapiro

Theresa A Shapiro

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Theresa A Shapiro

Theresa A Shapiro

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Kinetic Driver of Antibacterial Drugs against and Implications for Clinical Dosing.

Antimicrob Agents Chemother 2019 11 22;63(11). Epub 2019 Oct 22.

Division of Clinical Pharmacology, Departments of Medicine and of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

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http://dx.doi.org/10.1128/AAC.00416-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6811425PMC
November 2019

Optimal kinetic exposures for classic and candidate antitrypanosomals.

J Antimicrob Chemother 2019 Aug;74(8):2303-2310

Division of Clinical Pharmacology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1093/jac/dkz160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6640303PMC
August 2019

Activity of Aromathecins against African Trypanosomes.

Antimicrob Agents Chemother 2018 11 24;62(11). Epub 2018 Oct 24.

Division of Clinical Pharmacology, Departments of Medicine and of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

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http://dx.doi.org/10.1128/AAC.00786-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201061PMC
November 2018

Effect of Antiretroviral Therapy on Plasma Concentrations of Chloroquine and Desethyl-chloroquine.

Clin Infect Dis 2018 10;67(10):1617-1620

Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1093/cid/ciy405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206114PMC
October 2018

Model System Identifies Kinetic Driver of Hsp90 Inhibitor Activity against African Trypanosomes and Plasmodium falciparum.

Antimicrob Agents Chemother 2018 08 27;62(8). Epub 2018 Jul 27.

Division of Clinical Pharmacology, Departments of Medicine and of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

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http://dx.doi.org/10.1128/AAC.00056-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105818PMC
August 2018

Semi-quantitative measurement of the antimalarial lumefantrine from untreated dried blood spots using LC-MS/MS.

J Pharm Biomed Anal 2018 Jun 5;155:241-246. Epub 2018 Apr 5.

Department of Clinical Pharmacology, School of Pharmacology, University of California San Francisco, USA.

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http://dx.doi.org/10.1016/j.jpba.2018.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949273PMC
June 2018

Long-acting injectable atovaquone nanomedicines for malaria prophylaxis.

Nat Commun 2018 01 22;9(1):315. Epub 2018 Jan 22.

Division of Clinical Pharmacology, Departments of Medicine and of Pharmacology and Molecular Sciences, The Johns Hopkins University, 725 North Wolfe Street, Baltimore, MD, 21205, USA.

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http://dx.doi.org/10.1038/s41467-017-02603-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778127PMC
January 2018

NCCN Guidelines Insights: Malignant Pleural Mesothelioma, Version 3.2016.

J Natl Compr Canc Netw 2016 07;14(7):825-36

From The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Huntsman Cancer Institute at the University of Utah; UC San Diego Moores Cancer Center; Fox Chase Cancer Center; University of Colorado Cancer Center; Roswell Park Cancer Institute; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Moffitt Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Vanderbilt-Ingram Cancer Center; UCSF Helen Diller Family Comprehensive Cancer Center; The University of Texas MD Anderson Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; Yale Cancer Center/Smilow Cancer Hospital; University of Michigan Comprehensive Cancer Center; Stanford Cancer Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; City of Hope Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Mayo Clinic Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; and National Comprehensive Cancer Network.

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http://dx.doi.org/10.6004/jnccn.2016.0087DOI Listing
July 2016

Hollow-Fiber Methodology for Pharmacokinetic/Pharmacodynamic Studies of Antimalarial Compounds.

Curr Protoc Chem Biol 2016 Mar 16;8(1):29-58. Epub 2016 Mar 16.

Division of Clinical Pharmacology, Departments of Medicine and of Pharmacology and Molecular Sciences, and The Johns Hopkins Malaria Research Institute, The Johns Hopkins University, Baltimore, Maryland.

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http://dx.doi.org/10.1002/9780470559277.ch150194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811375PMC
March 2016

Targeting the gyrase of Plasmodium falciparum with topoisomerase poisons.

Biochem Pharmacol 2015 Jun 13;95(4):227-37. Epub 2015 Apr 13.

Division of Clinical Pharmacology, Department of Medicine, The Johns Hopkins University, Baltimore, MD, United States; Malaria Research Institute, The Johns Hopkins University, Baltimore, MD, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2015.03.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449814PMC
June 2015

Non-Small Cell Lung Cancer, Version 6.2015.

J Natl Compr Canc Netw 2015 May;13(5):515-24

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; University of Washington/Seattle Cancer Care Alliance; Huntsman Cancer Institute at the University of Utah; UC San Diego Moores Cancer Center; Fox Chase Cancer Center; University of Colorado Cancer Center; Roswell Park Cancer Institute; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Moffitt Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; City of Hope Comprehensive Cancer Center; Vanderbilt-Ingram Cancer Center; UCSF Helen Diller Family Comprehensive Cancer Center; The University of Texas MD Anderson Cancer Center; Memorial Sloan Kettering Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; Yale Cancer Center/Smilow Cancer Hospital; University of Michigan Comprehensive Cancer Center; Stanford Cancer Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Mayo Clinic Cancer Center; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; and National Comprehensive Cancer Network.

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http://dx.doi.org/10.6004/jnccn.2015.0071DOI Listing
May 2015

Membrane active chelators as novel anti-African trypanosome and anti-malarial drugs.

Parasitol Int 2013 Oct 28;62(5):461-3. Epub 2013 Jun 28.

Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.parint.2013.06.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838884PMC
October 2013

Model system to define pharmacokinetic requirements for antimalarial drug efficacy.

Sci Transl Med 2013 Oct;5(205):205ra135

Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins University, 725 North Wolfe Street, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1126/scitranslmed.3006684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845824PMC
October 2013

Potent antitrypanosomal activities of heat shock protein 90 inhibitors in vitro and in vivo.

J Infect Dis 2013 Aug 22;208(3):489-99. Epub 2013 Apr 22.

Department of Pharmacology and Molecular Sciences, The Johns Hopkins UniversitySchool of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1093/infdis/jit179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699005PMC
August 2013

Protection of humans by plant glucosinolates: efficiency of conversion of glucosinolates to isothiocyanates by the gastrointestinal microflora.

Cancer Prev Res (Phila) 2012 Apr 7;5(4):603-11. Epub 2012 Feb 7.

Lewis B. and Dorothy Cullman Chemoprotection Center, Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, 725 N. Wolfe Street (WBSB 406), Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1158/1940-6207.CAPR-11-0538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618677PMC
April 2012

Malaria-infected mice are completely cured by one 6 mg/kg oral dose of a new monomeric trioxane sulfide combined with mefloquine.

J Med Chem 2012 Jan 15;55(1):291-6. Epub 2011 Dec 15.

Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218-2685, United States.

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http://dx.doi.org/10.1021/jm201214dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257372PMC
January 2012

The killing of African trypanosomes by ethidium bromide.

PLoS Pathog 2010 Dec 16;6(12):e1001226. Epub 2010 Dec 16.

Department of Biological Chemistry, Johns Hopkins Medical School, Baltimore, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1001226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002999PMC
December 2010

Newly identified antibacterial compounds are topoisomerase poisons in African trypanosomes.

Antimicrob Agents Chemother 2010 Feb 14;54(2):620-6. Epub 2009 Dec 14.

Department of Medicine, The Johns Hopkins University School of Medicine, 301 Hunterian Building, 725 North Wolfe Street, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1128/AAC.01025-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812133PMC
February 2010

Malaria-infected mice live until at least day 30 after a new monomeric trioxane combined with mefloquine are administered together in a single low oral dose.

J Med Chem 2009 Dec;52(23):7458-62

Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218-2685, USA.

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http://dx.doi.org/10.1021/jm9005934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788671PMC
December 2009

Malaria-Infected Mice Are Cured by a Single Low Dose of a New Silylamide Trioxane Plus Mefloquine.

Pharmaceuticals (Basel) 2009 Dec 21;2(3):228-235. Epub 2009 Dec 21.

Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218-2685, MD, USA.

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http://dx.doi.org/10.3390/ph2030228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978545PMC
December 2009

Unraveling the secrets of regulating mitochondrial DNA replication.

Mol Cell 2009 Aug;35(4):398-400

Department of Microbiology, University of Massachusetts, Amherst, MA 01003, USA.

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http://dx.doi.org/10.1016/j.molcel.2009.08.007DOI Listing
August 2009

Phase I/II evaluation of the prophylactic antimalarial activity of pafuramidine in healthy volunteers challenged with Plasmodium falciparum sporozoites.

Am J Trop Med Hyg 2009 Apr;80(4):528-35

Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763313PMC
April 2009

Malaria-infected mice are cured by a single oral dose of new dimeric trioxane sulfones which are also selectively and powerfully cytotoxic to cancer cells.

J Med Chem 2009 Feb;52(4):1198-203

Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218-2685, USA.

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http://dx.doi.org/10.1021/jm801484vDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698029PMC
February 2009

Fumagillin and fumarranol interact with P. falciparum methionine aminopeptidase 2 and inhibit malaria parasite growth in vitro and in vivo.

Chem Biol 2009 Feb;16(2):193-202

Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.chembiol.2009.01.006DOI Listing
February 2009

Activity of indenoisoquinolines against African trypanosomes.

Antimicrob Agents Chemother 2009 Jan 29;53(1):123-8. Epub 2008 Sep 29.

Department of Medicine, Division of Clinical Pharmacology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1128/AAC.00650-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2612167PMC
January 2009

A mitochondrial topoisomerase IA essential for late theta structure resolution in African trypanosomes.

Mol Microbiol 2008 Feb 19;67(4):820-9. Epub 2007 Dec 19.

Division of Clinical Pharmacology, Department of Medicine and of Pharmacology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1111/j.1365-2958.2007.06087.xDOI Listing
February 2008

Malaria-infected mice are cured by oral administration of new artemisinin derivatives.

J Med Chem 2008 Feb 31;51(4):1035-42. Epub 2008 Jan 31.

Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218-2685, USA.

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http://dx.doi.org/10.1021/jm701168hDOI Listing
February 2008

Malaria-infected mice are cured by a single dose of novel artemisinin derivatives.

J Med Chem 2007 May 17;50(10):2516-9. Epub 2007 Apr 17.

Department of Chemistry, School of Arts and Sciences, The Johns Hopkins Malaria Research Institute, Johns Hopkins University, Baltimore, Maryland 21218, USA.

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http://dx.doi.org/10.1021/jm070149mDOI Listing
May 2007

Induction of the phase 2 response in mouse and human skin by sulforaphane-containing broccoli sprout extracts.

Cancer Epidemiol Biomarkers Prev 2007 Apr;16(4):847-51

Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, 725 North Wolfe Street, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1158/1055-9965.EPI-06-0934DOI Listing
April 2007

Safety, tolerance, and metabolism of broccoli sprout glucosinolates and isothiocyanates: a clinical phase I study.

Nutr Cancer 2006 ;55(1):53-62

Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1207/s15327914nc5501_7DOI Listing
January 2007

Second generation, orally active, antimalarial, artemisinin-derived trioxane dimers with high stability, efficacy, and anticancer activity.

J Med Chem 2006 May;49(9):2731-4

Department of Chemistry, The Johns Hopkins University, Baltimore, Maryland 21218-2685, USA.

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http://dx.doi.org/10.1021/jm058288wDOI Listing
May 2006

Distinct genes encode type II Topoisomerases for the nucleus and mitochondrion in the protozoan parasite Trypanosoma brucei.

J Biol Chem 2006 Feb 28;281(6):3048-56. Epub 2005 Nov 28.

Division of Clinical Pharmacology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1074/jbc.M505977200DOI Listing
February 2006

Molecular mechanisms of resistance in antimalarial chemotherapy: the unmet challenge.

Annu Rev Pharmacol Toxicol 2005 ;45:565-85

Division of Infectious Diseases, Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1146/annurev.pharmtox.45.120403.095946DOI Listing
May 2005

RNA interference of Trypanosoma brucei topoisomerase IB: both subunits are essential.

Mol Biochem Parasitol 2004 Aug;136(2):249-55

Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.molbiopara.2004.04.006DOI Listing
August 2004

Anticancer and antimalarial efficacy and safety of artemisinin-derived trioxane dimers in rodents.

J Med Chem 2004 Feb;47(5):1299-301

Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, 3400 N. Charles Street, Baltimore, Maryland 21218-2685, USA.

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http://pubs.acs.org/doi/abs/10.1021/jm0303711
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http://dx.doi.org/10.1021/jm0303711DOI Listing
February 2004

Antitrypanosomal activities of fluoroquinolones with pyrrolidinyl substitutions.

Antimicrob Agents Chemother 2003 Sep;47(9):3015-7

Departments of Medicine and of Pharmacology and Molecular Sciences, The Johns Hopkins University, Baltimore, Maryland 21205, USA.

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http://aac.asm.org/content/47/9/3015.full.pdf
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC182618PMC
http://dx.doi.org/10.1128/aac.47.9.3015-3017.2003DOI Listing
September 2003

A short synthesis and biological evaluation of potent and nontoxic antimalarial bridged bicyclic beta-sulfonyl-endoperoxides.

J Med Chem 2003 Jun;46(12):2516-33

Department of Organic Chemistry, The Weizmann Institute of Science, Rehovot 76100, Israel.

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http://dx.doi.org/10.1021/jm020584aDOI Listing
June 2003

An unusual type IB topoisomerase from African trypanosomes.

Proc Natl Acad Sci U S A 2003 Jun 16;100(13):7539-44. Epub 2003 Jun 16.

Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1073/pnas.1330762100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC164622PMC
June 2003

Orally active, antimalarial, anticancer, artemisinin-derived trioxane dimers with high stability and efficacy.

J Med Chem 2003 Mar;46(6):1060-5

Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218-2685, USA.

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http://dx.doi.org/10.1021/jm020461qDOI Listing
March 2003

Antimalarial chemotherapeutic peroxides: artemisinin, yingzhaosu A and related compounds.

Int J Parasitol 2002 Dec;32(13):1661-7

Department of Chemistry, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218-2685, USA.

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http://dx.doi.org/10.1016/s0020-7519(02)00195-9DOI Listing
December 2002

Orally active, water-soluble antimalarial 3-aryltrioxanes: short synthesis and preclinical efficacy testing in rodents.

J Med Chem 2002 Aug;45(18):3824-8

Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, 3400 N. Charles Street, Baltimore, Maryland 21218-2685, USA.

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http://dx.doi.org/10.1021/jm020210hDOI Listing
August 2002

Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: pharmacokinetics of broccoli sprout isothiocyanates in humans.

Clin Chim Acta 2002 Feb;316(1-2):43-53

Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/s0009-8981(01)00727-6DOI Listing
February 2002

New chemical and biological aspects of artemisinin-derived trioxane dimers.

Bioorg Med Chem 2002 Jan;10(1):227-32

Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, Baltimore, MD 21218, USA.

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http://dx.doi.org/10.1016/s0968-0896(01)00270-xDOI Listing
January 2002