Theodorus Van der Kwast

Theodorus Van der Kwast

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Theodorus Van der Kwast

Theodorus Van der Kwast

Publications by authors named "Theodorus Van der Kwast"

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EAU-EANM-ESTRO-ESUR-SIOG Prostate Cancer Guideline Panel Consensus Statements for Deferred Treatment with Curative Intent for Localised Prostate Cancer from an International Collaborative Study (DETECTIVE Study).

Eur Urol 2019 Dec 3;76(6):790-813. Epub 2019 Oct 3.

Department of Urology, University Hospital Jean Monnet, St. Etienne, France.

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http://dx.doi.org/10.1016/j.eururo.2019.09.020DOI Listing
December 2019

Long-term oncological outcomes of patients with paratesticular sarcoma.

BJU Int 2019 Nov 6;124(5):801-810. Epub 2019 May 6.

Departments of Surgery and Surgical Oncology (Division of Urology), Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, ON, Canada.

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http://doi.wiley.com/10.1111/bju.14775
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http://dx.doi.org/10.1111/bju.14775DOI Listing
November 2019

Cistrome Partitioning Reveals Convergence of Somatic Mutations and Risk Variants on Master Transcription Regulators in Primary Prostate Tumors.

Cancer Cell 2019 Nov 4. Epub 2019 Nov 4.

Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada; Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.10.005DOI Listing
November 2019

Grading Noninvasive Bladder Cancer: World Health Organisation 1973 or 2004 May Be the Wrong Question.

Eur Urol 2019 Oct 10;76(4):413-415. Epub 2019 May 10.

Laboratory Medicine Program, University Health Network, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1016/j.eururo.2019.05.001DOI Listing
October 2019

Methylation Markers in Prostate Biopsies Are Prognosticators for Late Biochemical Recurrence and Therapy after Surgery in Prostate Cancer Patients.

J Mol Diagn 2019 Oct 9. Epub 2019 Oct 9.

Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Sinai Health System, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada; Division of Urology, University Health Network, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2019.08.003DOI Listing
October 2019

Editorial Comment.

J Urol 2019 Oct 30:10109701JU0000612396093094f. Epub 2019 Oct 30.

Department of Pathology, Erasmus Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1097/01.JU.0000612396.09309.4fDOI Listing
October 2019

An integrative DNA methylation model for improved prognostication of postsurgery recurrence and therapy in prostate cancer patients.

Urol Oncol 2019 Sep 24. Epub 2019 Sep 24.

Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON; Institute of Medical Science, University of Toronto, Toronto, ON; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON; Department of Surgery and Surgical Oncology, Division of Urology, University Health Network, Toronto, ON. Electronic address:

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http://dx.doi.org/10.1016/j.urolonc.2019.08.017DOI Listing
September 2019

An actionable sterol-regulated feedback loop modulates statin sensitivity in prostate cancer.

Mol Metab 2019 07 10;25:119-130. Epub 2019 Apr 10.

Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, M5G 1L7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2019.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600047PMC
July 2019

A Phase 1 Pilot Study of Preoperative Radiation Therapy for Prostate Cancer: Long-Term Toxicity and Oncologic Outcomes.

Int J Radiat Oncol Biol Phys 2019 05 6;104(1):61-66. Epub 2019 Jan 6.

Department of Radiation Oncology, University of Toronto, Toronto, Canada; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; Techna Institute, University Health Network, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2018.12.054DOI Listing
May 2019

GBX2 Methylation Is a Novel Prognostic Biomarker and Improves Prediction of Biochemical Recurrence Among Patients with Prostate Cancer Negative for Intraductal Carcinoma and Cribriform Architecture.

Eur Urol Oncol 2019 May 1;2(3):231-238. Epub 2018 Sep 1.

Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada; Institute of Medical Science, University of Toronto, Toronto, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada; Departments of Surgery and Surgical Oncology, Division of Urology, University Health Network, Toronto, Canada; Department of Pathology and Laboratory Medicine, University Health Network, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.euo.2018.08.003DOI Listing
May 2019

Evolving concepts in prostatic neuroendocrine manifestations: from focal divergent differentiation to amphicrine carcinoma.

Hum Pathol 2019 03 24;85:313-327. Epub 2018 Nov 24.

Department of Pathology, University Health Network, Toronto, ON M5G 2C4, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A1, Canada; Endocrine Oncology, The Princess Margaret Cancer Centre, Toronto, ON M5G 2M9, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00468177183046
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http://dx.doi.org/10.1016/j.humpath.2018.11.016DOI Listing
March 2019

The Proteogenomic Landscape of Curable Prostate Cancer.

Cancer Cell 2019 Mar;35(3):414-427.e6

Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada; Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Human Genetics, University of California, 12-109 CHS, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA; Department of Urology, University of California, Los Angeles, CA 90024, USA; Jonsson Comprehensive Cancer Centre, University of California, Los Angeles, CA 90024, USA; Institute for Precision Health, University of California, Los Angeles, CA 90024, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511374PMC
March 2019

Exploring targets of TET2-mediated methylation reprogramming as potential discriminators of prostate cancer progression.

Clin Epigenetics 2019 03 27;11(1):54. Epub 2019 Mar 27.

Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 60 Murray Street, L6-304B, Toronto, ON, M5T 3L9, Canada.

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http://dx.doi.org/10.1186/s13148-019-0651-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438015PMC
March 2019

Concordance of biopsy and prostatectomy diagnosis of intraductal and cribriform carcinoma in a prospectively collected data set.

Histopathology 2019 Feb 4;74(3):474-482. Epub 2018 Nov 4.

Departments of Pathology, Laboratory Medicine Program, University Health Network, Toronto, Canada.

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http://doi.wiley.com/10.1111/his.13747
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http://dx.doi.org/10.1111/his.13747DOI Listing
February 2019

Genomic Classifier for Guiding Treatment of Intermediate-Risk Prostate Cancers to Dose-Escalated Image Guided Radiation Therapy Without Hormone Therapy.

Int J Radiat Oncol Biol Phys 2019 01 29;103(1):84-91. Epub 2018 Aug 29.

Princess Margaret Cancer Centre, University Health Network, Ontario, Canada; Division of Radiation Oncology, National Cancer Centre Singapore, Singapore; Division of Medical Sciences, National Cancer Centre Singapore, Singapore; Oncology Academic Program, Duke-NUS Medical School, Singapore.

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http://dx.doi.org/10.1016/j.ijrobp.2018.08.030DOI Listing
January 2019

Are there differences between de novo and secondary upper tract urothelial carcinoma tumours?

Can Urol Assoc J 2019 Jan 21:E292-E299. Epub 2019 Jan 21.

Division of Urology, Department of Surgical Oncology, Princess Margaret Cancer Center, University Health Network and the University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.5489/cuaj.5595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754256PMC
January 2019

Magnetic resonance guided focused high frequency ultrasound ablation for focal therapy in prostate cancer - phase 1 trial.

Eur Radiol 2018 Oct 25;28(10):4281-4287. Epub 2018 Apr 25.

Division of Urology, Department of Surgery, University Health Network, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/s00330-018-5409-zDOI Listing
October 2018

Risk SNP-Mediated Promoter-Enhancer Switching Drives Prostate Cancer through lncRNA PCAT19.

Cell 2018 07 19;174(3):564-575.e18. Epub 2018 Jul 19.

Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 2M9, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.06.014DOI Listing
July 2018

Editorial Comment.

J Urol 2018 06 12;199(6):1509. Epub 2018 Mar 12.

Laboratory Medicine Program and Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.juro.2017.12.079DOI Listing
June 2018

The Evolutionary Landscape of Localized Prostate Cancers Drives Clinical Aggression.

Cell 2018 05 19;173(4):1003-1013.e15. Epub 2018 Apr 19.

Informatics and Biocomputing Program, Ontario Institute for Cancer Research, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.03.029DOI Listing
May 2018

The mTOR Targets 4E-BP1/2 Restrain Tumor Growth and Promote Hypoxia Tolerance in PTEN-driven Prostate Cancer.

Mol Cancer Res 2018 04 16;16(4):682-695. Epub 2018 Feb 16.

Princess Margaret Cancer Centre and Campbell Family Institute for Cancer Research, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/1541-7786.MCR-17-0696DOI Listing
April 2018

On cribriform prostate cancer.

Transl Androl Urol 2018 Feb;7(1):145-154

Department of Pathology, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands.

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http://dx.doi.org/10.21037/tau.2017.12.33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861292PMC
February 2018

The New Realization About Cribriform Prostate Cancer.

Adv Anat Pathol 2018 Jan;25(1):31-37

Department of Pathology, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/PAP.0000000000000168DOI Listing
January 2018

Suspicious findings on micro-ultrasound imaging and early detection of prostate cancer.

Urol Case Rep 2018 Jan 21;16:98-100. Epub 2017 Nov 21.

Department of Pathology, Toronto General Hospital, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.eucr.2017.11.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711692PMC
January 2018

Intraductal Carcinoma of the Prostate: Anonymous to Ominous.

Eur Urol 2017 10 14;72(4):496-498. Epub 2017 Apr 14.

Radiation Medicine Program, Princess Margaret Cancer Center, University Health Network, Toronto, Canada; Departments of Radiation Oncology and Medical Biophysics, University of Toronto, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2017.04.004DOI Listing
October 2017

Creation and internal validation of a biopsy avoidance prediction tool to aid in the choice of diagnostic approach in patients with prostate cancer suspicion.

Urol Oncol 2017 10 7;35(10):604.e17-604.e24. Epub 2017 Aug 7.

Department of Surgery, University Health Network, University of Toronto, Toronto, Canada; Department of Pathology, University Health Network, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1016/j.urolonc.2017.06.044DOI Listing
October 2017

TMPRSS2-ERG fusion co-opts master transcription factors and activates NOTCH signaling in primary prostate cancer.

Nat Genet 2017 Sep 7;49(9):1336-1345. Epub 2017 Aug 7.

Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/ng.3930DOI Listing
September 2017

Prostate cancer: Draft USPSTF 2017 recommendation on PSA testing - a sea-change?

Nat Rev Urol 2017 Aug 13;14(8):457-458. Epub 2017 Jun 13.

Department of Urology, Erasmus Medical Center, Wytemaweg 80, 3015 CN Rotterdam, Netherlands.

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http://dx.doi.org/10.1038/nrurol.2017.89DOI Listing
August 2017

Translating a Prognostic DNA Genomic Classifier into the Clinic: Retrospective Validation in 563 Localized Prostate Tumors.

Eur Urol 2017 07 1;72(1):22-31. Epub 2016 Nov 1.

Informatics and Biocomputing Program, Ontario Institute for Cancer Research, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2016.10.013DOI Listing
July 2017

Variant Histology and Clinicopathological Features of Prostate Cancer in Men Younger than 50 Years Treated with Radical Prostatectomy.

J Urol 2017 07 24;198(1):79-85. Epub 2017 Jan 24.

Department of Pathology, Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada; Division of Urology, Department of Surgery (MEN, NEF), University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.juro.2017.01.061DOI Listing
July 2017

Propensity Score Analysis of Radical Cystectomy Versus Bladder-Sparing Trimodal Therapy in the Setting of a Multidisciplinary Bladder Cancer Clinic.

J Clin Oncol 2017 Jul 14;35(20):2299-2305. Epub 2017 Apr 14.

Girish S. Kulkarni, Thomas Hermanns, Yanliang Wei, Bimal Bhindi, Raj Satkunasivam, Paul Athanasopoulos, Peter J. Bostrom, Kathy Li, Arnoud J. Templeton, Srikala S. Sridhar, Peter Chung, Robert G. Bristow, Michael Milosevic, Padraig Warde, Neil E. Fleshner, Michael A.S. Jewett, Shaheena Bashir, and Alexandre R. Zlotta, Princess Margaret Cancer Center, University Health Network, University of Toronto; Cynthia Kuk and Alexandre R. Zlotta, Mount Sinai Hospital, University of Toronto; Theodorus H. Van Der Kwast, University Health Network, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1200/JCO.2016.69.2327DOI Listing
July 2017

Epigenome-Wide DNA Methylation Profiling Identifies Differential Methylation Biomarkers in High-Grade Bladder Cancer.

Transl Oncol 2017 Apr 3;10(2):168-177. Epub 2017 Feb 3.

Lunenfeld-Tanenbaum Research Institute, Sinai Health System, 60 Murray St., Toronto, Ontario, Canada, M5T 3L9; Department of Laboratory Medicine and Pathobiology, University of Toronto, 27 King's College Circle, Toronto, Ontario, Canada, M5S 1A1; Department of Pathology, University Health Network, 200 Elizabeth St., Toronto, Ontario, Canada, M5G 2C4. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19365233163025
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http://dx.doi.org/10.1016/j.tranon.2017.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293735PMC
April 2017

microRNAs and DICER1 are regulated by 1,25-dihydroxyvitamin D in prostate stroma.

J Steroid Biochem Mol Biol 2017 03 12;167:192-202. Epub 2017 Jan 12.

Department of Pathology, University of Illinois at Chicago, Chicago, IL, United States; University of Illinois Cancer Center, Chicago, IL, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2017.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5304339PMC
March 2017

Urinary DNA Methylation Biomarkers for Noninvasive Prediction of Aggressive Disease in Patients with Prostate Cancer on Active Surveillance.

J Urol 2017 02 18;197(2):335-341. Epub 2016 Aug 18.

Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada; Department of Pathology, University Health Network, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.juro.2016.08.081DOI Listing
February 2017

Limitations in Predicting Organ Confined Prostate Cancer in Patients with Gleason Pattern 4 on Biopsy: Implications for Active Surveillance.

J Urol 2017 01 22;197(1):75-83. Epub 2016 Jul 22.

Division of Urology, Department of Surgical Oncology, University Health Network, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.juro.2016.07.076DOI Listing
January 2017

Analysis of papillary urothelial carcinomas of the bladder with grade heterogeneity: supportive evidence for an early role of CDKN2A deletions in the FGFR3 pathway.

Histopathology 2017 Jan 28;70(2):281-289. Epub 2016 Oct 28.

Department of Pathology, University Health Network and Princess Margaret Cancer Center, Toronto, Canada.

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http://dx.doi.org/10.1111/his.13063DOI Listing
January 2017

Lymph node staging in prostate cancer: perspective for the pathologist.

J Clin Pathol 2016 Dec 23;69(12):1039-1045. Epub 2016 Aug 23.

Department of Pathology, Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1136/jclinpath-2016-203643DOI Listing
December 2016

Clonality of localized and metastatic prostate cancer.

Curr Opin Urol 2016 May;26(3):219-24

aDepartment of Medical Biophysics, University of Toronto bInformatics and Biocomputing Program, Ontario Institute for Cancer Research cDepartment of Pharmacology and Toxicology, University of Toronto dPrincess Margaret Cancer Centre, University Health Network eDepartment of Pathology, Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/MOU.0000000000000279DOI Listing
May 2016

Dynamic interplay between locus-specific DNA methylation and hydroxymethylation regulates distinct biological pathways in prostate carcinogenesis.

Clin Epigenetics 2016 15;8:32. Epub 2016 Mar 15.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON Canada ; Mount Sinai Hospital, Lunenfeld-Tanenbaum Research Institute, Toronto, ON Canada.

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http://dx.doi.org/10.1186/s13148-016-0195-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791926PMC
April 2016

Assessment of intravascular granulomas in testicular seminomas and their association with tumour relapse and dissemination.

J Clin Pathol 2016 Jan 20;69(1):47-52. Epub 2015 Jul 20.

Department of Pathology, Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada.

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http://jcp.bmj.com/lookup/doi/10.1136/jclinpath-2015-202997
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http://dx.doi.org/10.1136/jclinpath-2015-202997DOI Listing
January 2016

Not all gleason pattern 4 prostate cancers are created equal: A study of latent prostatic carcinomas in a cystoprostatectomy and autopsy series.

Prostate 2015 Sep 11;75(12):1277-84. Epub 2015 May 11.

Department of Laboratory Medicine and Pathology, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pros.23009DOI Listing
September 2015

Real-Time MRI-Guided Focused Ultrasound for Focal Therapy of Locally Confined Low-Risk Prostate Cancer: Feasibility and Preliminary Outcomes.

AJR Am J Roentgenol 2015 Aug;205(2):W177-84

2 Department of Surgical Oncology, Division of Urology, University Health Network, University of Toronto, Toronto ON, Canada.

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http://dx.doi.org/10.2214/AJR.14.13098DOI Listing
August 2015

Spatial genomic heterogeneity within localized, multifocal prostate cancer.

Nat Genet 2015 Jul 25;47(7):736-45. Epub 2015 May 25.

1] Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. [2] Ontario Cancer Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. [3] Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/ng.3315DOI Listing
July 2015

Differential expression and regulation of vitamin D hydroxylases and inflammatory genes in prostate stroma and epithelium by 1,25-dihydroxyvitamin D in men with prostate cancer and an in vitro model.

J Steroid Biochem Mol Biol 2015 Apr 8;148:156-65. Epub 2014 Oct 8.

Department of Pathology, University of Illinois at Chicago, IL, USA; University of Illinois Cancer Center, Chicago, IL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2014.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361379PMC
April 2015

Genomic, pathological, and clinical heterogeneity as drivers of personalized medicine in prostate cancer.

Urol Oncol 2015 Feb 24;33(2):85-94. Epub 2014 Apr 24.

Department of Pathology and Laboratory Medicine, Toronto General Hospital (University Health Network), Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.urolonc.2013.10.020DOI Listing
February 2015

Prostate cancer: Is prostatectomy for Gleason score 6 a treatment failure?

Nat Rev Urol 2015 Jan 9;12(1):10-1. Epub 2014 Dec 9.

Department of Urology, Erasmus Medical Centre, 's-Gravendijkwal 230, 3015 CE, Rotterdam, Netherlands.

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http://dx.doi.org/10.1038/nrurol.2014.335DOI Listing
January 2015

Next-generation RNA sequencing of archival formalin-fixed paraffin-embedded urothelial bladder cancer.

Eur Urol 2014 Dec 6;66(6):982-6. Epub 2014 Sep 6.

The Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2014.07.045DOI Listing
December 2014

Obesity is associated with risk of progression for low-risk prostate cancers managed expectantly.

Eur Urol 2014 Nov 18;66(5):841-8. Epub 2014 Jun 18.

Division of Urology, Department of Surgery, University Health Network, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.eururo.2014.06.005DOI Listing
November 2014

Regular transition zone biopsy during active surveillance for prostate cancer may improve detection of pathological progression.

J Urol 2014 Oct 15;192(4):1088-93. Epub 2014 Apr 15.

Division of Surgical Oncology, Department of Uro-oncology, Princess Margaret Cancer Center, University Health Network; Department of Radiology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada; Department of Pathology, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada; Department of Medicine, University of Toronto, Toronto, Ontario, Canada; Department of Urology, St. Vincent's Hospital and Austin Health, University of Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1016/j.juro.2014.04.010DOI Listing
October 2014

SeqControl: process control for DNA sequencing.

Nat Methods 2014 Oct 31;11(10):1071-5. Epub 2014 Aug 31.

1] Informatics &Biocomputing Platform, Ontario Institute for Cancer Research, Toronto, Ontario, Canada. [2] Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. [3] Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/nmeth.3094DOI Listing
October 2014

Integrated analysis of epigenomic and genomic changes by DNA methylation dependent mechanisms provides potential novel biomarkers for prostate cancer.

Oncotarget 2014 Sep;5(17):7858-69

Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital. Department of Laboratory Medicine and Pathobiology, University of Toronto. Department of Pathology, University Health Network, Toronto, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202166PMC
http://dx.doi.org/10.18632/oncotarget.2313DOI Listing
September 2014

Fibroblast growth factor receptor 3 activation plays a causative role in urothelial cancer pathogenesis in cooperation with Pten loss in mice.

J Pathol 2014 Jun 31;233(2):148-58. Epub 2014 Mar 31.

School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK; Beatson Institute for Cancer Research, Glasgow, UK.

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http://dx.doi.org/10.1002/path.4334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612374PMC
June 2014

Prognostic impact of intraductal carcinoma and large cribriform carcinoma architecture after prostatectomy in a contemporary cohort.

Eur J Cancer 2014 Jun 3;50(9):1610-6. Epub 2014 Apr 3.

Dept. of Pathology and Laboratory Medicine, University Health Network, 200 Elizabeth St, Toronto, ON M5G 2C4, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2014.03.009DOI Listing
June 2014

Striated muscle in the prostatic apex: does the amount in radical prostatectomy specimens predict postprostatectomy urinary incontinence?

Urology 2014 Apr;83(4):888-92

Division of Urology, Department of Surgery, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.urology.2013.12.055DOI Listing
April 2014

Prognostic prostate tissue biomarkers of potential clinical use.

Virchows Arch 2014 Mar 1;464(3):293-300. Epub 2014 Feb 1.

Department of Pathology, Princess Margaret Cancer Center and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada,

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http://dx.doi.org/10.1007/s00428-014-1540-7DOI Listing
March 2014

Novel multiplex MethyLight protocol for detection of DNA methylation in patient tissues and bodily fluids.

Sci Rep 2014 Mar 21;4:4432. Epub 2014 Mar 21.

1] Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada [2] Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada [3] Department of Pathology and Laboratory Medicine, University Health Network, Toronto, Ontario, Canada.

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http://www.nature.com/articles/srep04432
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http://dx.doi.org/10.1038/srep04432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961737PMC
March 2014