Theodorus H van der Kwast

Theodorus H van der Kwast

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Theodorus H van der Kwast

Theodorus H van der Kwast

Publications by authors named "Theodorus H van der Kwast"

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EAU-EANM-ESTRO-ESUR-SIOG Prostate Cancer Guideline Panel Consensus Statements for Deferred Treatment with Curative Intent for Localised Prostate Cancer from an International Collaborative Study (DETECTIVE Study).

Eur Urol 2019 Oct 3. Epub 2019 Oct 3.

Department of Urology, University Hospital Jean Monnet, St. Etienne, France.

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http://dx.doi.org/10.1016/j.eururo.2019.09.020DOI Listing
October 2019

An actionable sterol-regulated feedback loop modulates statin sensitivity in prostate cancer.

Mol Metab 2019 Jul 10;25:119-130. Epub 2019 Apr 10.

Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, M5G 1L7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2019.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600047PMC
July 2019

Magnetic resonance guided focused high frequency ultrasound ablation for focal therapy in prostate cancer - phase 1 trial.

Eur Radiol 2018 Oct 25;28(10):4281-4287. Epub 2018 Apr 25.

Division of Urology, Department of Surgery, University Health Network, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/s00330-018-5409-zDOI Listing
October 2018

Editorial Comment.

J Urol 2018 06 12;199(6):1509. Epub 2018 Mar 12.

Laboratory Medicine Program and Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.juro.2017.12.079DOI Listing
June 2018

The mTOR Targets 4E-BP1/2 Restrain Tumor Growth and Promote Hypoxia Tolerance in PTEN-driven Prostate Cancer.

Mol Cancer Res 2018 04 16;16(4):682-695. Epub 2018 Feb 16.

Princess Margaret Cancer Centre and Campbell Family Institute for Cancer Research, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/1541-7786.MCR-17-0696DOI Listing
April 2018

Intraductal Carcinoma of the Prostate: Anonymous to Ominous.

Eur Urol 2017 10 14;72(4):496-498. Epub 2017 Apr 14.

Radiation Medicine Program, Princess Margaret Cancer Center, University Health Network, Toronto, Canada; Departments of Radiation Oncology and Medical Biophysics, University of Toronto, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2017.04.004DOI Listing
October 2017

Creation and internal validation of a biopsy avoidance prediction tool to aid in the choice of diagnostic approach in patients with prostate cancer suspicion.

Urol Oncol 2017 10 7;35(10):604.e17-604.e24. Epub 2017 Aug 7.

Department of Surgery, University Health Network, University of Toronto, Toronto, Canada; Department of Pathology, University Health Network, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1016/j.urolonc.2017.06.044DOI Listing
October 2017

Prostate cancer: Draft USPSTF 2017 recommendation on PSA testing - a sea-change?

Nat Rev Urol 2017 Aug 13;14(8):457-458. Epub 2017 Jun 13.

Department of Urology, Erasmus Medical Center, Wytemaweg 80, 3015 CN Rotterdam, Netherlands.

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http://dx.doi.org/10.1038/nrurol.2017.89DOI Listing
August 2017

Variant Histology and Clinicopathological Features of Prostate Cancer in Men Younger than 50 Years Treated with Radical Prostatectomy.

J Urol 2017 07 24;198(1):79-85. Epub 2017 Jan 24.

Department of Pathology, Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada; Division of Urology, Department of Surgery (MEN, NEF), University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.juro.2017.01.061DOI Listing
July 2017

Propensity Score Analysis of Radical Cystectomy Versus Bladder-Sparing Trimodal Therapy in the Setting of a Multidisciplinary Bladder Cancer Clinic.

J Clin Oncol 2017 Jul 14;35(20):2299-2305. Epub 2017 Apr 14.

Girish S. Kulkarni, Thomas Hermanns, Yanliang Wei, Bimal Bhindi, Raj Satkunasivam, Paul Athanasopoulos, Peter J. Bostrom, Kathy Li, Arnoud J. Templeton, Srikala S. Sridhar, Peter Chung, Robert G. Bristow, Michael Milosevic, Padraig Warde, Neil E. Fleshner, Michael A.S. Jewett, Shaheena Bashir, and Alexandre R. Zlotta, Princess Margaret Cancer Center, University Health Network, University of Toronto; Cynthia Kuk and Alexandre R. Zlotta, Mount Sinai Hospital, University of Toronto; Theodorus H. Van Der Kwast, University Health Network, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1200/JCO.2016.69.2327DOI Listing
July 2017

Epigenome-Wide DNA Methylation Profiling Identifies Differential Methylation Biomarkers in High-Grade Bladder Cancer.

Transl Oncol 2017 Apr 3;10(2):168-177. Epub 2017 Feb 3.

Lunenfeld-Tanenbaum Research Institute, Sinai Health System, 60 Murray St., Toronto, Ontario, Canada, M5T 3L9; Department of Laboratory Medicine and Pathobiology, University of Toronto, 27 King's College Circle, Toronto, Ontario, Canada, M5S 1A1; Department of Pathology, University Health Network, 200 Elizabeth St., Toronto, Ontario, Canada, M5G 2C4. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19365233163025
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http://dx.doi.org/10.1016/j.tranon.2017.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293735PMC
April 2017

Analysis of papillary urothelial carcinomas of the bladder with grade heterogeneity: supportive evidence for an early role of CDKN2A deletions in the FGFR3 pathway.

Histopathology 2017 Jan 28;70(2):281-289. Epub 2016 Oct 28.

Department of Pathology, University Health Network and Princess Margaret Cancer Center, Toronto, Canada.

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http://dx.doi.org/10.1111/his.13063DOI Listing
January 2017

Lymph node staging in prostate cancer: perspective for the pathologist.

J Clin Pathol 2016 Dec 23;69(12):1039-1045. Epub 2016 Aug 23.

Department of Pathology, Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1136/jclinpath-2016-203643DOI Listing
December 2016

Assessment of intravascular granulomas in testicular seminomas and their association with tumour relapse and dissemination.

J Clin Pathol 2016 Jan 20;69(1):47-52. Epub 2015 Jul 20.

Department of Pathology, Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada.

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http://jcp.bmj.com/lookup/doi/10.1136/jclinpath-2015-202997
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http://dx.doi.org/10.1136/jclinpath-2015-202997DOI Listing
January 2016

Real-Time MRI-Guided Focused Ultrasound for Focal Therapy of Locally Confined Low-Risk Prostate Cancer: Feasibility and Preliminary Outcomes.

AJR Am J Roentgenol 2015 Aug;205(2):W177-84

2 Department of Surgical Oncology, Division of Urology, University Health Network, University of Toronto, Toronto ON, Canada.

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http://dx.doi.org/10.2214/AJR.14.13098DOI Listing
August 2015

Prostate cancer: Is prostatectomy for Gleason score 6 a treatment failure?

Nat Rev Urol 2015 Jan 9;12(1):10-1. Epub 2014 Dec 9.

Department of Urology, Erasmus Medical Centre, 's-Gravendijkwal 230, 3015 CE, Rotterdam, Netherlands.

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http://dx.doi.org/10.1038/nrurol.2014.335DOI Listing
January 2015

Next-generation RNA sequencing of archival formalin-fixed paraffin-embedded urothelial bladder cancer.

Eur Urol 2014 Dec 6;66(6):982-6. Epub 2014 Sep 6.

The Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2014.07.045DOI Listing
December 2014

Obesity is associated with risk of progression for low-risk prostate cancers managed expectantly.

Eur Urol 2014 Nov 18;66(5):841-8. Epub 2014 Jun 18.

Division of Urology, Department of Surgery, University Health Network, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.eururo.2014.06.005DOI Listing
November 2014

Prognostic impact of intraductal carcinoma and large cribriform carcinoma architecture after prostatectomy in a contemporary cohort.

Eur J Cancer 2014 Jun 3;50(9):1610-6. Epub 2014 Apr 3.

Dept. of Pathology and Laboratory Medicine, University Health Network, 200 Elizabeth St, Toronto, ON M5G 2C4, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2014.03.009DOI Listing
June 2014

Prognostic prostate tissue biomarkers of potential clinical use.

Virchows Arch 2014 Mar 1;464(3):293-300. Epub 2014 Feb 1.

Department of Pathology, Princess Margaret Cancer Center and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada,

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http://dx.doi.org/10.1007/s00428-014-1540-7DOI Listing
March 2014

Diagnostic utility of androgen receptor expression in discriminating poorly differentiated urothelial and prostate carcinoma.

J Clin Pathol 2013 Sep 17;66(9):779-86. Epub 2013 Jun 17.

Department of Pathology and Laboratory Medicine, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1136/jclinpath-2013-201586DOI Listing
September 2013

Length matters in prostate cancer.

Can J Urol 2013 Aug;20(4):6854

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August 2013

Perineural invasion on prostate biopsy does not predict adverse pathological outcome.

Can J Urol 2012 Dec;19(6):6567-72

University of Toronto, Toronto, Ontario, Canada.

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December 2012

Focal magnetic resonance guided focused ultrasound for prostate cancer: Initial North American experience.

Can Urol Assoc J 2012 Dec;6(6):E283-6

Division of Urology, Department of Surgical Oncology, University Health Network, and Department of Surgery, University of Toronto, Toronto, ON;

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http://dx.doi.org/10.5489/cuaj.12218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529739PMC
December 2012

Measurement of peri-prostatic fat thickness using transrectal ultrasonography (TRUS): a new risk factor for prostate cancer.

BJU Int 2012 Oct 28;110(7):980-6. Epub 2012 Feb 28.

Division of Urology, Department of Surgical Oncology, University Health Network (UHN), University of Toronto, Toronto, Ontario, Canada.

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http://doi.wiley.com/10.1111/j.1464-410X.2012.10957.x
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http://dx.doi.org/10.1111/j.1464-410X.2012.10957.xDOI Listing
October 2012

The value of triple antibody (34βE12 + p63 + AMACR) cocktail stain in radical prostatectomy specimens with crushed surgical margins.

J Clin Pathol 2012 May 31;65(5):437-40. Epub 2012 Jan 31.

Department of Pathology and Microbiology, Jordan University of Science and Technology, Irbid, Jordan.

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http://dx.doi.org/10.1136/jclinpath-2011-200533DOI Listing
May 2012

Epithelioid angiomyolipoma: a morphologically distinct variant that mimics a variety of intra-abdominal neoplasms.

Arch Pathol Lab Med 2011 May;135(5):665-70

Department of Pathology, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1043/2009-0637-RSR.1DOI Listing
May 2011

Neoadjuvant radiotherapy for locally advanced and high-risk prostate cancer.

Nat Rev Clin Oncol 2011 Feb 21;8(2):107-13. Epub 2010 Dec 21.

Radiation Medicine Program, Princess Margaret Hospital, University Health Network, 5th Floor, Room 5-808, 610 University Avenue, Toronto, ON M5G 2M9, Canada.

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http://dx.doi.org/10.1038/nrclinonc.2010.207DOI Listing
February 2011

Long-term follow-up of T1 high-grade bladder cancer after intravesical bacille Calmette-Guérin treatment.

BJU Int 2011 Feb 7;107(4):540-6. Epub 2010 Sep 7.

Department of Surgical Oncology (Division of Urology), Princess Margaret Hospital, Mount Sinai Hospital, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1111/j.1464-410X.2010.09572.xDOI Listing
February 2011

Prostate cancer localization with multispectral MRI using cost-sensitive support vector machines and conditional random fields.

IEEE Trans Image Process 2010 Sep;19(9):2444-55

Medical Imaging Research Center, Illinois Institute of Technology, Chicago, IL 60616, USA.

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http://dx.doi.org/10.1109/TIP.2010.2048612DOI Listing
September 2010

DNA methylation of HOXD3 as a marker of prostate cancer progression.

Lab Invest 2010 Jul 8;90(7):1060-7. Epub 2010 Mar 8.

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.

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http://dx.doi.org/10.1038/labinvest.2010.57DOI Listing
July 2010

Should pathologists routinely report prostate tumour volume? The prognostic value of tumour volume in prostate cancer.

Eur Urol 2010 May 29;57(5):821-9. Epub 2009 Jul 29.

Department of Pathology, Erasmus MC, Rotterdam, The Netherlands; Department of Urology, Erasmus MC, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.eururo.2009.07.027DOI Listing
May 2010

Prostate tissue composition and MR measurements: investigating the relationships between ADC, T2, K(trans), v(e), and corresponding histologic features.

Radiology 2010 May;255(2):485-94

Department of Medical Imaging, Princess Margaret Hospital, University Health Network and Mount Sinai Hospital, 610 University Ave, Room 3-958, Toronto, ON, Canada M5G 2M9.

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http://dx.doi.org/10.1148/radiol.10091343DOI Listing
May 2010

Supervised and unsupervised methods for prostate cancer segmentation with multispectral MRI.

Med Phys 2010 Apr;37(4):1873-83

Department of Electrical and Computer Engineering, Medical Imaging Research Center, Illinois Institute of Technology, Chicago, Illinois 60616, USA.

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http://dx.doi.org/10.1118/1.3359459DOI Listing
April 2010

False-negative prostate needle biopsies: frequency, histopathologic features, and follow-up.

Am J Surg Pathol 2010 Jan;34(1):35-43

Department of Pathology, Erasmus Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1097/PAS.0b013e3181c3ece9DOI Listing
January 2010

Predicting favourable prognosis of urothelial carcinoma: gene expression and genome profiling.

Curr Opin Urol 2009 Sep;19(5):516-21

Department of Pathology, University Health Network and University of Toronto, Canada.

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http://dx.doi.org/10.1097/MOU.0b013e32832eb45fDOI Listing
September 2009

Prostate cancer detection with multi-parametric MRI: logistic regression analysis of quantitative T2, diffusion-weighted imaging, and dynamic contrast-enhanced MRI.

J Magn Reson Imaging 2009 Aug;30(2):327-34

Department of Medical Imaging, Princess Margaret Hospital, University Health Network and Mount Sinai Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/jmri.21824DOI Listing
August 2009

Is incidentally detected prostate cancer in patients undergoing radical cystoprostatectomy clinically significant?

Am J Clin Pathol 2009 Feb;131(2):279-83

Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy.

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http://dx.doi.org/10.1309/AJCP4OCYZBAN9TJUDOI Listing
February 2009

Intermixed normal tissue within prostate cancer: effect on MR imaging measurements of apparent diffusion coefficient and T2--sparse versus dense cancers.

Radiology 2008 Dec;249(3):900-8

Joint Department of Medical Imaging, Princess Margaret Hospital, University Health Network, University of Toronto, Rm 3-958, 610 University Ave, Toronto, ON, Canada M5G 2M9.

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http://dx.doi.org/10.1148/radiol.2493080236DOI Listing
December 2008

Thirty-five years of noninvasive bladder carcinoma: a plea for the use of papillary intraurothelial neoplasia as new terminology.

Anal Quant Cytol Histol 2008 Dec;30(6):309-15

Department of Pathology and Laboratory Medicine, University Health Network and Mount Sinai Hospital, University of Toronto, Ontario, Canada.

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December 2008

Lesions of ductal morphology in the prostate.

Arch Pathol Lab Med 2008 Mar;132(3):319-20; author reply 320-1

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http://dx.doi.org/10.1043/1543-2165(2008)132[319b:LODMIT]2.0.CO;2DOI Listing
March 2008

Identification of patients with prostate cancer who benefit from immediate postoperative radiotherapy: EORTC 22911.

J Clin Oncol 2007 Sep;25(27):4178-86

Department of Pathology and Laboratory Medicine, Mount Sinai Hospital and University Health Network, Toronto, Canada.

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http://dx.doi.org/10.1200/JCO.2006.10.4067DOI Listing
September 2007

Combined T2-weighted and diffusion-weighted MRI for localization of prostate cancer.

AJR Am J Roentgenol 2007 Aug;189(2):323-8

Joint Department of Medical Imaging, Princess Margaret Hospital, University Health Network and Mount Sinai Hospital, University of Toronto, 610 University Ave., Toronto, ON M5G 2M9, Canada.

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http://dx.doi.org/10.2214/AJR.07.2211DOI Listing
August 2007

Impact of pathology review of stage and margin status of radical prostatectomy specimens (EORTC trial 22911).

Virchows Arch 2006 Oct 29;449(4):428-34. Epub 2006 Aug 29.

Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada, and Department of Urology, Universitair Ziekenhuis Gasthuisberg, Leuven, Belgium.

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http://dx.doi.org/10.1007/s00428-006-0254-xDOI Listing
October 2006

The actual value of the surgical margin status as a predictor of disease progression in men with early prostate cancer.

Eur Urol 2006 Aug 6;50(2):258-65. Epub 2006 Jan 6.

Department of Urology, Erasmus Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.eururo.2005.11.030DOI Listing
August 2006

Large cell neuroendocrine carcinoma of prostate: a clinicopathologic summary of 7 cases of a rare manifestation of advanced prostate cancer.

Am J Surg Pathol 2006 Jun;30(6):684-93

Department of Pathology and Laboratory Medicine, University Health Network, Mt Sinai Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/00000478-200606000-00003DOI Listing
June 2006

Prognostic markers in nephroblastoma (Wilms' tumor).

Urology 2005 Jun;65(6):1047-54

Department of Pediatric Urology, Josephine Nefkens Institute, Erasmus University Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.urology.2004.12.005DOI Listing
June 2005

Lesions predictive for prostate cancer in a screened population: first and second screening round findings.

Prostate 2004 Nov;61(3):260-6

Department of Urology, Erasmus MC Rotterdam, The Netherlands.

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http://dx.doi.org/10.1002/pros.20105DOI Listing
November 2004

Potentially advanced malignancies detected by screening for prostate carcinoma after an interval of 4 years.

Cancer 2004 Mar;100(5):968-75

Department of Urology, Erasmus Medical Center, Rotterdam, The Netherlands.

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http://doi.wiley.com/10.1002/cncr.20048
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http://dx.doi.org/10.1002/cncr.20048DOI Listing
March 2004