Publications by authors named "Theodore W Laetsch"

46Publications

Chimeric antigen receptor T-cell therapy for acute lymphocytic leukaemia: where are we in 2020?

Lancet Haematol 2020 Nov;7(11):e778-e779

Division of Oncology, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/S2352-3026(20)30284-2DOI Listing
November 2020

Functional imaging of RAS pathway targeting in malignant peripheral nerve sheath tumor cells and xenografts.

Pediatr Blood Cancer 2020 Dec 25;67(12):e28639. Epub 2020 Sep 25.

Department of Pediatrics Division of Hematology/Oncology, University of Texas Southwestern Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1002/pbc.28639DOI Listing
December 2020

Before It's Too Late: Multistakeholder Perspectives on Compassionate Access to Investigational Drugs for Pediatric Patients With Cancer.

Am Soc Clin Oncol Educ Book 2020 May;40:1-10

Department of Pediatrics, UT Southwestern Medical Center, Dallas, TX.

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http://dx.doi.org/10.1200/EDBK_278995DOI Listing
May 2020

Improving the Time to Activation of New Clinical Trials at a National Cancer Institute-Designated Comprehensive Cancer Center.

JCO Oncol Pract 2020 Apr 16;16(4):e324-e332. Epub 2020 Jan 16.

Harold C. Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, TX.

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http://dx.doi.org/10.1200/OP.19.00325DOI Listing
April 2020

Immunoglobulin replacement and quality of life after CAR T-cell therapy - Authors' reply.

Lancet Oncol 2020 01;21(1):e7

Department of Pediatrics, University of Utah, Salt Lake City, UT, USA.

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http://dx.doi.org/10.1016/S1470-2045(19)30814-9DOI Listing
January 2020

CD19 CAR T Cells for the Treatment of Pediatric Pre-B Cell Acute Lymphoblastic Leukemia.

Paediatr Drugs 2020 Feb;22(1):1-11

Division of Pediatric Hematology-Oncology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390-9063, USA.

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http://dx.doi.org/10.1007/s40272-019-00370-6DOI Listing
February 2020

Novel rearrangement in multifocal infantile myofibromatosis is tumorigenic and sensitive to imatinib.

Cold Spring Harb Mol Case Stud 2019 10 23;5(5). Epub 2019 Oct 23.

Division of Hematology/Oncology, Departments of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

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http://dx.doi.org/10.1101/mcs.a004440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824247PMC
October 2019

Tisagenlecleucel Model-Based Cellular Kinetic Analysis of Chimeric Antigen Receptor-T Cells.

CPT Pharmacometrics Syst Pharmacol 2019 05 7;8(5):285-295. Epub 2019 Mar 7.

Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1002/psp4.12388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539725PMC
May 2019

TRK Fusion Cancers in Children: A Clinical Review and Recommendations for Screening.

J Clin Oncol 2019 02 28;37(6):513-524. Epub 2018 Dec 28.

University of Texas Southwestern Medical Center/Children's Health, Dallas, TX.

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http://dx.doi.org/10.1200/JCO.18.00573DOI Listing
February 2019

Larotrectinib for the treatment of TRK fusion solid tumors.

Expert Rev Anticancer Ther 2019 01 24;19(1):1-10. Epub 2018 Oct 24.

b Seattle Children's Hospital , University of Washington, Fred Hutchinson Cancer Research Center , Seattle , WA , USA.

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https://www.tandfonline.com/doi/full/10.1080/14737140.2019.1
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http://dx.doi.org/10.1080/14737140.2019.1538796DOI Listing
January 2019

Durable Clinical Response to Larotrectinib in an Adolescent Patient With an Undifferentiated Sarcoma Harboring an - Fusion.

JCO Precis Oncol 2018 2;2. Epub 2018 Aug 2.

, , , , and , The University of Texas Southwestern Medical Center; , , , , , , , and , Children's Health, Dallas, TX; , , , , and , Foundation Medicine, Cambridge, MA; and and , Loxo Oncology, South San Francisco, CA.

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http://dx.doi.org/10.1200/PO.18.00101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7446438PMC
August 2018

Integrative Bayesian Analysis Identifies Rhabdomyosarcoma Disease Genes.

Cell Rep 2018 07;24(1):238-251

Department of Pediatrics, Division of Hematology/Oncology, University of Texas Southwestern Medical Center, Dallas, TX; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX; Gill Center for Cancer and Blood Disorders, Children's Health, Children's Medical Center, Dallas, TX. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293769PMC
July 2018

Pan-Trk Immunohistochemistry Identifies NTRK Rearrangements in Pediatric Mesenchymal Tumors.

Am J Surg Pathol 2018 07;42(7):927-935

Department of Pathology, University of California San Francisco, San Francisco, CA.

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http://dx.doi.org/10.1097/PAS.0000000000001062DOI Listing
July 2018

Efficacy of Larotrectinib in TRK Fusion-Positive Cancers in Adults and Children.

N Engl J Med 2018 02;378(8):731-739

From Memorial Sloan Kettering Cancer Center (A. Drilon, J.F.H., R.B., M.L., D.M.H.) and Weill Cornell Medical College (A. Drilon, D.M.H.), New York; University of Texas Southwestern Medical Center-Children's Health, Dallas (T.W.L.); Stanford Cancer Center, Stanford University, Palo Alto (S.K.), Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California (L.M.), and UCLA David Geffen School of Medicine (N.F.), Los Angeles, and Loxo Oncology, South San Francisco (B.B.T., K.E., S.C., N.C.K., M.C.C.) - all in California; Dana-Farber-Boston Children's Cancer and Blood Disorders Center (S.G.D.), Dana-Farber Cancer Institute (G.D.D., M.N.), Ludwig Center at Harvard (G.D.D.), and Massachusetts General Hospital (A.F.F.) - all in Boston; the Finsen Center, Rigshospitalet, Copenhagen (U.N.L.); University of Colorado, Aurora (R.C.D.); St. Jude Children's Research Hospital, Memphis (A.S.P.), and Vanderbilt University, Nashville (J.B.) - both in Tennessee; Cincinnati Children's Hospital Medical Center, Cincinnati (B.T.); University Hospitals of Cleveland Medical Center (A. Dowlati) and Taussig Cancer Institute, Cleveland Clinic (D.P.S.S.), Cleveland; University of Pennsylvania Perelman School of Medicine, Department of Otorhinolaryngology and Head and Neck Surgery, and the Abramson Cancer Center (M.S.B.), and Fox Chase Cancer Center (W.S.E.-D.), Philadelphia; University of Washington-Seattle Cancer Care Alliance (C.B.), Seattle Children's Hospital (E.R.R.), and Seattle Children's Hospital, University of Washington, Fred Hutchinson Cancer Research Center (D.S. Hawkins), Seattle; University of Texas M.D. Anderson Cancer Center, Houston (F.M.-B., D.S. Hong); Inova Schar Cancer Institute, Falls Church, VA (J.D.); START Madrid, Centro Integral Oncológico Clara Campal, Madrid (V.B.); Nemours Children's Hospital, Orlando (R.N.), and Memorial Cancer Institute-Florida International University, Miami (L.E.R.) - both in Florida; Oregon Health and Science University, Portland (M.T.); and WVU Cancer Institute, West Virginia University, Morgantown (P.C.M.).

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http://dx.doi.org/10.1056/NEJMoa1714448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857389PMC
February 2018

Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia.

N Engl J Med 2018 02;378(5):439-448

From the Departments of Pediatrics (S.L.M., S.A.G.) and Pathology and Laboratory Medicine (C.H.J., B.L.L.), Perelman School of Medicine, and Abramson Cancer Center (C.H.J., B.L.L.), University of Pennsylvania, and the Division of Oncology, Center for Childhood Cancer Research and Cancer Immunotherapy Program, Children's Hospital of Philadelphia (S.L.M., S.A.G.) - all in Philadelphia; the Department of Pediatrics and Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, and the Pauline Allen Gill Center for Cancer and Blood Disorders, Children's Health, Dallas (T.W.L.); the Department of Pediatric Hematology and Oncology, Oslo University Hospital, Oslo (J.B.); the Department of Pediatric Hematology and Oncology, Hospital Sant Joan de Deu Barcelona, Barcelona (S.R.); the Department of Pediatrics and Internal Medicine, University of Utah, Salt Lake City (M.B.); the Department of Pediatrics, Faculty of Medicine, University of Montreal, and the Hematology Oncology Division and Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine Research Center, Montreal (H.B.), and the Division of Haematology/Oncology/Bone Marrow Transplantation, Hospital for Sick Children, Toronto (J.K.) - all in Canada; the Division of Stem Cell Transplantation and Immunology, Hospital for Children and Adolescents, University Hospital Frankfurt, Frankfurt, Germany (P.B.); the Division of Pediatric Blood and Marrow Transplant, University of Minnesota, Minneapolis (M.R.V., H.E.S.); Children's Mercy Hospital and Clinics, Kansas City, MO (G.D.M.); Aflac Cancer and Blood Disorders Center, Emory University, Atlanta (M.Q.); the Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, and the Cancer Research Institute Ghent (CRIG), Ghent, Belgium (B.D.M.); the Department of Pediatrics, Graduate School of Medicine Kyoto University, Kyoto, Japan (H.H.); the Department of Pediatrics, Stanford University School of Medicine, Stanford (K. Schlis, K.L.D.), and the Division of Hematology, Oncology, Blood and Marrow Transplant, Children's Hospital Los Angeles, USC Keck School of Medicine, Los Angeles (M.A.P.) - all in California; the Division of Pediatric Blood and Marrow Transplant, Duke University Medical Center, Durham, NC (P.L.M.); Oregon Health and Science University, Portland (E.R.N.); C.S. Mott Children's Hospital, Ann Arbor, MI (G.A.Y.); the Stem Cell Transplantation Unit, St. Anna Children's Hospital, Vienna (C.P.); University Hospital Robert Debré and University Paris Diderot (A. Baruchel), and Saint-Louis Hospital and University Paris Diderot (N.B.), Paris; the Royal Children's Hospital, Melbourne, VIC, Australia (F.M.); Clinica Pediatrica Universita degli Studi di Milano Bicocca, Monza, Italy (A. Balduzzi); and Novartis Pharmaceuticals (P.W., T.T., M.L., Y.Z., K. Sen, D.L.) and Novartis Institutes for Biomedical Research (K.T.M.) - both in East Hanover, NJ.

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http://dx.doi.org/10.1056/NEJMoa1709866DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996391PMC
February 2018

Redefining treatment failure for pediatric acute leukemia in the era of minimal residual disease testing.

Pediatr Hematol Oncol 2017 Sep - Oct;34(6-7):395-408. Epub 2017 Nov 30.

f Cancer and Blood Diseases Institute , Cincinnati Children's Hospital Medical Center , Cincinnati , OH , USA.

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http://dx.doi.org/10.1080/08880018.2017.1397073DOI Listing
July 2018

Comprehensive Analysis of Hypermutation in Human Cancer.

Cell 2017 Nov 19;171(5):1042-1056.e10. Epub 2017 Oct 19.

Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada; Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.09.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849393PMC
November 2017

Targeting NTRK fusions for the treatment of congenital mesoblastic nephroma.

Pediatr Blood Cancer 2018 01 25;65(1). Epub 2017 Apr 25.

Pediatric Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

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http://dx.doi.org/10.1002/pbc.26593DOI Listing
January 2018

Pediatric oncology enters an era of precision medicine.

Curr Probl Cancer 2017 May - Jun;41(3):194-200. Epub 2017 Feb 1.

Department of Pediatrics, Baylor College of Medicine, Houston, Texas; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas.

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http://dx.doi.org/10.1016/j.currproblcancer.2017.01.002DOI Listing
March 2018

Potential pitfalls of mass spectrometry to uncover mutations in childhood soft tissue sarcoma: A report from the Children's Oncology Group.

Sci Rep 2016 09 19;6:33429. Epub 2016 Sep 19.

Department of Pediatrics Division of Hematology/Oncology, and the Harold C. Simmons Cancer Center, University of Texas Southwestern Medical Center, and the Pauline Allen Gill Center for Cancer and Blood Disorders, Children's Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1038/srep33429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027578PMC
September 2016

Drift correction for accurate PRF-shift MR thermometry during mild hyperthermia treatments with MR-HIFU.

Int J Hyperthermia 2016 09 22;32(6):673-87. Epub 2016 May 22.

a Department of Radiology , University of Texas Southwestern Medical Center , Dallas , Texas , USA ;

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045807PMC
http://dx.doi.org/10.1080/02656736.2016.1179799DOI Listing
September 2016

Pediatric Sarcomas Are Targetable by MR-Guided High Intensity Focused Ultrasound (MR-HIFU): Anatomical Distribution and Radiological Characteristics.

Pediatr Blood Cancer 2016 10 19;63(10):1753-60. Epub 2016 May 19.

Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1002/pbc.26079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016837PMC
October 2016

Polyamine Antagonist Therapies Inhibit Neuroblastoma Initiation and Progression.

Clin Cancer Res 2016 Sep 24;22(17):4391-404. Epub 2016 Mar 24.

Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-2539DOI Listing
September 2016