Theodore J Lampidis

Theodore J Lampidis

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Theodore J Lampidis

Theodore J Lampidis

Publications by authors named "Theodore J Lampidis"

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33Publications

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Targeting the Kynurenine Pathway for the Treatment of Cisplatin-Resistant Lung Cancer.

Mol Cancer Res 2020 Jan 18;18(1):105-117. Epub 2019 Oct 18.

Department of Veterans Affairs, Miami VA Healthcare System, Research Service, Miami, Florida.

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http://dx.doi.org/10.1158/1541-7786.MCR-19-0239DOI Listing
January 2020

2-Deoxy-Glucose Downregulates Endothelial AKT and ERK via Interference with N-Linked Glycosylation, Induction of Endoplasmic Reticulum Stress, and GSK3β Activation.

Mol Cancer Ther 2016 Feb 4;15(2):264-75. Epub 2015 Dec 4.

Department of Medicine, Division of Hematology-Oncology, University of Miami Miller School of Medicine and Sylvester Comprehensive Cancer Center, Miami, Florida.

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http://dx.doi.org/10.1158/1535-7163.MCT-14-0315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747846PMC
February 2016

ATF4 mediates necrosis induced by glucose deprivation and apoptosis induced by 2-deoxyglucose in the same cells.

FEBS J 2015 Sep 1;282(18):3647-58. Epub 2015 Aug 1.

Cell Death Regulation Group, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Spain.

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http://dx.doi.org/10.1111/febs.13369DOI Listing
September 2015

Mcl-1 downregulation leads to the heightened sensitivity exhibited by BCR-ABL positive ALL to induction of energy and ER-stress.

Leuk Res 2015 Aug 20. Epub 2015 Aug 20.

Department of Pediatrics, Division of Hematology and Oncology, University of Miami Miller School of Medicine, Miami, FL 33101, USA; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33101, USA; Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33101, USA; Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33101, USA. Electronic address:

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http://dx.doi.org/10.1016/j.leukres.2015.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783293PMC
August 2015

Increased sensitivity to glucose starvation correlates with downregulation of glycogen phosphorylase isoform PYGB in tumor cell lines resistant to 2-deoxy-D-glucose.

Cancer Chemother Pharmacol 2014 Feb 1;73(2):349-61. Epub 2013 Dec 1.

Sheila and David Fuente Graduate Program in Cancer Biology, University of Miami Miller School of Medicine, 1550 NW 10th Avenue, Fox Building #406, Miami, FL, 33136, USA,

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http://dx.doi.org/10.1007/s00280-013-2358-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570497PMC
February 2014

Targeting cisplatin-resistant human tumor cells with metabolic inhibitors.

Cancer Chemother Pharmacol 2014 Feb 19;73(2):417-27. Epub 2013 Dec 19.

Department of Cell Biology and Anatomy, University of Miami Miller School of Medicine, P.O. Box 016960 (R124), Miami, FL, 33101, USA.

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http://dx.doi.org/10.1007/s00280-013-2366-8DOI Listing
February 2014

The wonders of 2-deoxy-D-glucose.

IUBMB Life 2014 Feb 27;66(2):110-21. Epub 2014 Feb 27.

Department of Microbiology, Immunology and Molecular Genetics, and Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, CA, USA.

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http://dx.doi.org/10.1002/iub.1251DOI Listing
February 2014

Conversion of 2-deoxyglucose-induced growth inhibition to cell death in normoxic tumor cells.

Cancer Chemother Pharmacol 2013 Jul 23;72(1):251-62. Epub 2013 May 23.

Department of Cell Biology and Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.

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http://link.springer.com/content/pdf/10.1007/s00280-013-2193
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http://link.springer.com/10.1007/s00280-013-2193-y
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http://dx.doi.org/10.1007/s00280-013-2193-yDOI Listing
July 2013

Endoplasmic reticulum stress induced by 2-deoxyglucose but not glucose starvation activates AMPK through CaMKKβ leading to autophagy.

Biochem Pharmacol 2013 May 13;85(10):1463-77. Epub 2013 Mar 13.

Sheila and David Fuente Graduate Program in Cancer Biology, University of Miami Miller School of Medicine, 1550 NW 10th Avenue, Fox Building #406, Miami, FL 33136, USA.

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http://dx.doi.org/10.1016/j.bcp.2013.02.037DOI Listing
May 2013

Models and discovery strategies for new therapies of retinoblastoma.

Expert Opin Drug Discov 2013 Apr 22;8(4):383-94. Epub 2013 Feb 22.

University of Miami, Bascom Palmer Eye Institute, Department of Ophthalmology, Miami, FL, USA.

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http://dx.doi.org/10.1517/17460441.2013.772975DOI Listing
April 2013

A phase I dose-escalation trial of 2-deoxy-D-glucose alone or combined with docetaxel in patients with advanced solid tumors.

Cancer Chemother Pharmacol 2013 Feb 11;71(2):523-30. Epub 2012 Dec 11.

Department of Medicine, Division of Hematology/Oncology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, PO Box 016960, Miami, FL 33101, USA.

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http://dx.doi.org/10.1007/s00280-012-2045-1DOI Listing
February 2013

Activation of the unfolded protein response by 2-deoxy-D-glucose inhibits Kaposi's sarcoma-associated herpesvirus replication and gene expression.

Antimicrob Agents Chemother 2012 Nov 27;56(11):5794-803. Epub 2012 Aug 27.

Viral Oncology Program, Sylvester Comprehensive Cancer Center, Miami Center for AIDS Research, and Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, Florida, USA.

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http://dx.doi.org/10.1128/AAC.01126-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3486618PMC
November 2012

Inhibition of Akt potentiates 2-DG-induced apoptosis via downregulation of UPR in acute lymphoblastic leukemia.

Mol Cancer Res 2012 Jul 12;10(7):969-78. Epub 2012 Jun 12.

Department of Pediatric Hematology-Oncology, University of Miami Miller School of Medicine, Miami, FL 33101, USA.

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http://mcr.aacrjournals.org/cgi/doi/10.1158/1541-7786.MCR-12
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http://dx.doi.org/10.1158/1541-7786.MCR-12-0125DOI Listing
July 2012

2-Deoxy-D-glucose activates autophagy via endoplasmic reticulum stress rather than ATP depletion.

Cancer Chemother Pharmacol 2011 Apr 1;67(4):899-910. Epub 2010 Jul 1.

Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, PAP Building, Room 115, 1550 NW 10th Ave, Miami, FL 33136, USA.

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http://dx.doi.org/10.1007/s00280-010-1391-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093301PMC
April 2011

Focal, periocular delivery of 2-deoxy-D-glucose as adjuvant to chemotherapy for treatment of advanced retinoblastoma.

Invest Ophthalmol Vis Sci 2010 Dec 11;51(12):6149-56. Epub 2010 Aug 11.

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33101, USA.

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http://dx.doi.org/10.1167/iovs.09-5033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3055749PMC
December 2010

Antiangiogenic activity of 2-deoxy-D-glucose.

PLoS One 2010 Oct 27;5(10):e13699. Epub 2010 Oct 27.

Department of Medicine, University of Miami Miller School of Medicine and Sylvester Comprehensive Cancer Center, Miami, Florida, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0013699PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965179PMC
October 2010

High endoplasmic reticulum activity renders multiple myeloma cells hypersensitive to mitochondrial inhibitors.

Cancer Chemother Pharmacol 2010 May 25;66(1):129-40. Epub 2009 Sep 25.

Department of Cell Biology and Anatomy and Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, 1550 NW 10th Ave, PAP Bldg, Room# 115, Miami, FL 33136, USA.

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http://dx.doi.org/10.1007/s00280-009-1143-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2918425PMC
May 2010

Increased hypoxia following vessel targeting in a murine model of retinoblastoma.

Invest Ophthalmol Vis Sci 2009 Dec 2;50(12):5537-43. Epub 2009 Jul 2.

Department of Ophthalmology, Bascom Palmer Eye Institute, Miami, FL 33101, USA.

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http://dx.doi.org/10.1167/iovs.09-3702DOI Listing
December 2009

Targeting hypoxia, a novel treatment for advanced retinoblastoma.

Invest Ophthalmol Vis Sci 2008 Jul 7;49(7):2799-805. Epub 2008 Mar 7.

Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, Florida 33101, USA.

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http://dx.doi.org/10.1167/iovs.08-1751DOI Listing
July 2008

Under normoxia, 2-deoxy-D-glucose elicits cell death in select tumor types not by inhibition of glycolysis but by interfering with N-linked glycosylation.

Mol Cancer Ther 2007 Nov;6(11):3049-58

Department of Cell Biologoy and Anatomy, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-07-0310DOI Listing
November 2007

Differential toxic mechanisms of 2-deoxy-D-glucose versus 2-fluorodeoxy-D-glucose in hypoxic and normoxic tumor cells.

Antioxid Redox Signal 2007 Sep;9(9):1383-90

University of Miami, Miller School of Medicine and Sylvester Cancer Center, Miami, Florida 33136, USA.

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http://dx.doi.org/10.1089/ars.2007.1714DOI Listing
September 2007

Hypoxia-inducible factor-1 confers resistance to the glycolytic inhibitor 2-deoxy-D-glucose.

Mol Cancer Ther 2007 Feb;6(2):732-41

Department of Cell Biology (R-124), University of Miami School of Medicine, P.O. Box 016960, 1600 Northwest 10th Avenue, Miami, FL 33101, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-06-0407DOI Listing
February 2007

Efficacy of 2-halogen substituted D-glucose analogs in blocking glycolysis and killing "hypoxic tumor cells".

Cancer Chemother Pharmacol 2006 Dec 23;58(6):725-34. Epub 2006 Mar 23.

School of Medicine and Sylvester Cancer Center, The University of Miami, Miami, FL, USA.

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http://dx.doi.org/10.1007/s00280-006-0207-8DOI Listing
December 2006

Greater cell cycle inhibition and cytotoxicity induced by 2-deoxy-D-glucose in tumor cells treated under hypoxic vs aerobic conditions.

Cancer Chemother Pharmacol 2004 Feb 7;53(2):116-22. Epub 2003 Nov 7.

Department of Cell Biology and Anatomy, University of Miami School of Medicine, Miami, FL 33101, USA.

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http://dx.doi.org/10.1007/s00280-003-0724-7DOI Listing
February 2004

Multidrug resistance correlates with overexpression of Muc4 but inversely with P-glycoprotein and multidrug resistance related protein in transfected human melanoma cells.

Biochem Pharmacol 2003 May;65(9):1419-25

Department of Cell Biology and Anatomy (R-124), University of Miami School of Medicine, P.O. Box 016960, Miami, FL 33101, USA.

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http://dx.doi.org/10.1016/s0006-2952(03)00086-8DOI Listing
May 2003

Hypoxia increases tumor cell sensitivity to glycolytic inhibitors: a strategy for solid tumor therapy (Model C).

Biochem Pharmacol 2002 Dec;64(12):1745-51

Department of Cell Biology and Anatomy (R-124), and Sylvester Comprehensive Cancer Center, University of Miami, School of Medicine, PO Box 016960, Miami, FL 33101, USA.

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http://dx.doi.org/10.1016/s0006-2952(02)01456-9DOI Listing
December 2002