Publications by authors named "Theodore J Brown"

52Publications

Cargo small non-coding RNAs of extracellular vesicles isolated from uterine fluid associate with endometrial receptivity and implantation success.

Fertil Steril 2020 Nov 30. Epub 2020 Nov 30.

Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada; Mount Sinai Fertility, Sinai Health System, Toronto, Ontario, Canada; Department of Obstetrics and Gynaecology, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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November 2020

The predicted collagen-binding domains of Drosophila SPARC are essential for survival and for collagen IV distribution and assembly into basement membranes.

Dev Biol 2020 05 20;461(2):197-209. Epub 2020 Feb 20.

Department of Cells and Systems Biology, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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May 2020

Increased androgen receptor levels and signaling in ovarian cancer cells by VEPH1 associated with suppression of SMAD3 and AKT activation.

J Steroid Biochem Mol Biol 2020 02 12;196:105498. Epub 2019 Oct 12.

Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, M5T 3L9, Canada; Department of Obstetrics and Gynaecology, University of Toronto, Toronto, Ontario, M5S 3G5, Canada. Electronic address:

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February 2020

Removing Short Wavelengths From Polychromatic White Light Attenuates Circadian Phase Resetting in Rats.

Front Neurosci 2019 10;13:954. Epub 2019 Sep 10.

Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, United States.

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September 2019

Wounding promotes ovarian cancer progression and decreases efficacy of cisplatin in a syngeneic mouse model.

J Ovarian Res 2018 Jul 4;11(1):56. Epub 2018 Jul 4.

Lunenfeld-Tanenbaum Research Institute at Sinai Health Systems, Mt. Sinai Hospital, 60 Murray Street, 6-10016-3, Toronto, ON, M5T 3L9, Canada.

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July 2018

BRCA1 Mutation Status and Follicular Fluid Exposure Alters NFκB Signaling and ISGylation in Human Fallopian Tube Epithelial Cells.

Neoplasia 2018 07 28;20(7):697-709. Epub 2018 May 28.

The Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON; Institute of Medical Sciences, University of Toronto, Toronto, ON; Department of Obstetrics and Gynecology, University of Toronto, Toronto, ON; Department of Physiology, University of Toronto, Toronto, ON. Electronic address:

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July 2018

The Two Faces of Adjuvant Glucocorticoid Treatment in Ovarian Cancer.

Horm Cancer 2018 04 8;9(2):95-107. Epub 2018 Jan 8.

Lunenfeld-Tanenbaum Research Institute at Sinai Health Systems, University of Toronto, Toronto, ON, Canada.

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April 2018

Collagen IV trafficking: The inside-out and beyond story.

Dev Biol 2017 11 2;431(2):124-133. Epub 2017 Oct 2.

Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada M5S 3G5. Electronic address:

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November 2017

VEPH1 expression decreases vascularisation in ovarian cancer xenografts and inhibits VEGFA and IL8 expression through inhibition of AKT activation.

Br J Cancer 2017 Apr 16;116(8):1065-1076. Epub 2017 Mar 16.

Lunenfeld-Tanenbaum Research Institute at Mount Sinai Hospital, 60 Murray Street, Toronto, M5T 3L9 ON, Canada.

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April 2017

In vitro Autoradiographic Analysis of Regional Changes in Estrogen Receptor Alpha in the Brains of Cycling Female Rats.

Neuroendocrinology 2016 1;103(5):538-51. Epub 2015 Oct 1.

Department of Biomedical Sciences, University of Guelph, Guelph, Ont., Canada.

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May 2017

Human ortholog of Drosophila Melted impedes SMAD2 release from TGF-β receptor I to inhibit TGF-β signaling.

Proc Natl Acad Sci U S A 2015 Jun 26;112(23):E3000-9. Epub 2015 May 26.

Lunenfeld-Tanenbaum Research Institute at Mount Sinai Hospital, Toronto, ON, Canada M5T 3H7; Departments of Physiology, Obstetrics and Gynaecology,

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June 2015

Slow binding kinetics of secreted protein, acidic, rich in cysteine-VEGF interaction limit VEGF activation of VEGF receptor 2 and attenuate angiogenesis.

FASEB J 2015 Aug 28;29(8):3493-505. Epub 2015 Apr 28.

*Sunnybrook Research Institute, Toronto, Ontario, Canada; Department of Medical Biophysics and Pharmaceutical Sciences, Department of Cell & Systems Biology, Department of Immunology, and Department of Obstetrics and Gynecology, University of Toronto, Ontario, Canada; and Lunenfeld-Tanenbaum Research Institute, Toronto, Ontario, Canada

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August 2015

Molecular profiling and clinical outcome of high-grade serous ovarian cancer presenting with low- versus high-volume ascites.

Biomed Res Int 2014 25;2014:367103. Epub 2014 May 25.

Division of Gynaecologic Oncology, Department of Obstetrics and Gynaecology, University of Toronto, Toronto, ON, Canada M5G 2M9 ; Division of Gynaecologic Oncology, Department of Obstetrics and Gynaecology, Princess Margaret Cancer Centre, Toronto, ON, Canada M5G 2M9.

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February 2015

Glucocorticoid-induced reversal of interleukin-1β-stimulated inflammatory gene expression in human oviductal cells.

PLoS One 2014 21;9(5):e97997. Epub 2014 May 21.

Department of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, Canada; Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, Ontario, Canada.

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January 2015

C-terminal region of teneurin-1 co-localizes with the dystroglycan complex in adult mouse testes and regulates testicular size and testosterone production.

Histochem Cell Biol 2014 Feb 24;141(2):191-211. Epub 2013 Oct 24.

Department of Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, ON, M5S 3G5, Canada,

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February 2014

Effects of filtering visual short wavelengths during nocturnal shiftwork on sleep and performance.

Chronobiol Int 2013 Oct 8;30(8):951-62. Epub 2013 Jul 8.

Fran and Lawrence Bloomberg Department of Obstetrics and Gynecology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.

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October 2013

C-terminal processing of the teneurin proteins: independent actions of a teneurin C-terminal associated peptide in hippocampal cells.

Mol Cell Neurosci 2013 Jan 28;52:38-50. Epub 2012 Sep 28.

Department of Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, ON, Canada M5S 3G5.

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January 2013

Prolonged postovulatory proinflammatory signaling in the fallopian tube epithelium may be mediated through a BRCA1/DAB2 axis.

Clin Cancer Res 2012 Aug 2;18(16):4334-44. Epub 2012 Jul 2.

The Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Canada.

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August 2012

Expression and function of nuclear receptor co-activator 4: evidence of a potential role independent of co-activator activity.

Cell Mol Life Sci 2012 Dec 5;69(23):3895-909. Epub 2012 May 5.

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 25 Orde Street, 6-1001TB, Toronto, ON, M5T 3H7, Canada.

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December 2012

Cell-cell and cell-matrix dynamics in intraperitoneal cancer metastasis.

Cancer Metastasis Rev 2012 Jun;31(1-2):397-414

Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada.

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June 2012

Pancreatic GLP-1 receptor activation is sufficient for incretin control of glucose metabolism in mice.

J Clin Invest 2012 Jan 19;122(1):388-402. Epub 2011 Dec 19.

Department of Medicine, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.

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January 2012

The impact of the ovarian microenvironment on the anti-tumor effect of SPARC on ovarian cancer.

Biochem Cell Biol 2012 Feb 17;90(1):96-107. Epub 2011 Oct 17.

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON M5T 3H7, Canada.

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February 2012

Dynamic distribution of nuclear coactivator 4 during mitosis: association with mitotic apparatus and midbodies.

PLoS One 2011 26;6(7):e22257. Epub 2011 Jul 26.

Department of Obstetrics and Gynecology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.

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December 2011

Decreased progesterone receptor isoform expression in luteal phase fallopian tube epithelium and high-grade serous carcinoma.

Endocr Relat Cancer 2011 Apr 23;18(2):221-34. Epub 2011 Feb 23.

The Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada M5G 1L4.

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April 2011

Spectral modulation attenuates molecular, endocrine, and neurobehavioral disruption induced by nocturnal light exposure.

Am J Physiol Endocrinol Metab 2011 Mar 21;300(3):E518-27. Epub 2010 Dec 21.

Samuel Lunenfeld Research Institute, 25 Orde St., Mount Sinai Hospital, Toronto, Ontario, Canada.

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March 2011

Maintaining mesenchymal properties of ovarian surface epithelial cells: a potential early protective role for TGF-beta in ovarian carcinogenesis.

Endocrinology 2010 Nov;151(11):5092-4

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Ontario, Canada.

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November 2010

Variable expression of nuclear receptor coactivator 4 (NcoA4) during mouse embryonic development.

J Histochem Cytochem 2010 Jul 30;58(7):595-609. Epub 2010 Mar 30.

Samuel Lunenfeld Research Institute, Mt. Sinai Hospital, Toronto, ON, Canada.

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July 2010

Four and a half LIM domain 2 alters the impact of aryl hydrocarbon receptor on androgen receptor transcriptional activity.

J Steroid Biochem Mol Biol 2010 Jan 6;118(1-2):51-8. Epub 2009 Oct 6.

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.

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January 2010

Compact spheroid formation by ovarian cancer cells is associated with contractile behavior and an invasive phenotype.

Int J Cancer 2009 May;124(9):2060-70

Department of Cell and Systems Biology, University of Toronto, Samuel Lunenfeld Research Institute, Mt. Sinai Hospital, Toronto, Ontario, Canada.

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May 2009

Modulation of aryl hydrocarbon receptor activity by four and a half LIM domain 2.

Int J Biochem Cell Biol 2009 May 28;41(5):1182-8. Epub 2008 Oct 28.

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5T 3H7.

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May 2009

Selectively filtering short wavelengths attenuates the disruptive effects of nocturnal light on endocrine and molecular circadian phase markers in rats.

Endocrinology 2008 Dec 7;149(12):6125-35. Epub 2008 Aug 7.

Fran and Lawrence Bloomberg Department of Obstetrics and Gynecology and Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5.

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December 2008

Collagen I but not Matrigel matrices provide an MMP-dependent barrier to ovarian cancer cell penetration.

BMC Cancer 2008 Aug 5;8:223. Epub 2008 Aug 5.

Department of Cell and Systems Biology, University of Toronto, Toronto, Canada.

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August 2008

Gene expression profiles of luteal phase fallopian tube epithelium from BRCA mutation carriers resemble high-grade serous carcinoma.

Clin Cancer Res 2008 Jul;14(13):4067-78

Department of Laboratory Medicine and Pathobiology, Division of Gynecologic Oncology, University of Toronto, Canada.

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July 2008

Functional interaction of nuclear receptor coactivator 4 with aryl hydrocarbon receptor.

Biochem Biophys Res Commun 2006 Jul 2;346(2):526-34. Epub 2006 Jun 2.

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ont., Canada.

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July 2006

Oxyntomodulin and glucagon-like peptide-1 differentially regulate murine food intake and energy expenditure.

Gastroenterology 2004 Aug;127(2):546-58

Department of Medicine, Banting and Best Diabetes Centre, Toronto General Hospital, University of Toronto, Ontario, Canada.

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August 2004

Secretion of endogenous kallikreins 2 and 3 by androgen receptor-transfected PC-3 prostate cancer cells.

J Steroid Biochem Mol Biol 2003 Apr;84(5):493-502

Samuel Lunenfeld Research Institute, Mt. Sinai Hospital, Suite 876, 600 University Avenue, Toronto, Ont., Canada M5G 1X5.

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April 2003

Novel functions of the matricellular proteins osteopontin and osteonectin/SPARC.

Connect Tissue Res 2002 ;43(2-3):308-19

CIHR Group in Matrix Dynamics, 234 FitzGerald Building, Faculty of Dentistry, University of Toronto, Toronto M5S 3E2, Canada.

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April 2003

Androgen modulation of adhesion and antiadhesion molecules in PC-3 prostate cancer cells expressing androgen receptor.

Endocrinology 2002 Oct;143(10):3897-904

Cancer and Blood Research Program, The Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8.

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October 2002

Interaction with Nedd8, a ubiquitin-like protein, enhances the transcriptional activity of the aryl hydrocarbon receptor.

J Biol Chem 2002 Nov 4;277(46):44028-34. Epub 2002 Sep 4.

Division of Reproductive Sciences, Samuel Lunenfeld Research Institute, Mount Sinai Hospital and Department of Zoology, University of Toronto, Ontario M5G 1X5, Canada.

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November 2002

Flavonoids can block PSA production by breast and prostate cancer cell lines.

Clin Chim Acta 2002 Mar;317(1-2):17-26

Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada.

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March 2002