Theodore E Warkentin

Theodore E Warkentin

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Theodore E Warkentin

Theodore E Warkentin

Publications by authors named "Theodore E Warkentin"

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High-dose intravenous immunoglobulin to treat spontaneous heparin-induced thrombocytopenia syndrome.

J Thromb Haemost 2019 May 14;17(5):841-844. Epub 2019 Mar 14.

Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1111/jth.14411DOI Listing
May 2019

Timeline of heparin-induced thrombocytopenia seroconversion in serial plasma samples tested using an automated latex immunoturbidimetric assay.

Int J Lab Hematol 2019 May 3. Epub 2019 May 3.

Department of Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ijlh.13031
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http://dx.doi.org/10.1111/ijlh.13031DOI Listing
May 2019

Laboratory diagnosis of heparin-induced thrombocytopenia.

Int J Lab Hematol 2019 May;41 Suppl 1:15-25

Department of Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1111/ijlh.12993DOI Listing
May 2019

Proposal of a two-step process for the diagnosis of sepsis-induced disseminated intravascular coagulation.

J Thromb Haemost 2019 May 16. Epub 2019 May 16.

Department of Medicine, University College London Hospitals NHS Foundation Trust, London, UK.

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http://dx.doi.org/10.1111/jth.14482DOI Listing
May 2019

The association between platelet transfusions and mortality in patients with critical illness.

Transfusion 2019 Apr 1. Epub 2019 Apr 1.

Department of Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1111/trf.15277DOI Listing
April 2019

Neutrophil and Monocyte Counts in Heparin-Induced Thrombocytopenia.

Thromb Haemost 2019 Apr 20. Epub 2019 Apr 20.

Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1055/s-0039-1683913DOI Listing
April 2019

An international external quality assessment for laboratory diagnosis of heparin-induced thrombocytopenia.

J Thromb Haemost 2019 Mar 20;17(3):525-531. Epub 2019 Feb 20.

Institut für Immunologie und Transfusionsmedizin, Universitätsmedizin Greifswald, Greifswald, Germany.

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http://dx.doi.org/10.1111/jth.14383DOI Listing
March 2019

Autoimmune heparin-induced thrombocytopenia and venous limb gangrene after aortic dissection repair: in vitro and in vivo effects of intravenous immunoglobulin.

Transfusion 2019 Mar 23. Epub 2019 Mar 23.

Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1111/trf.15263DOI Listing
March 2019

Microvascular Thrombosis and Ischaemic Limb Losses in Critically Ill Patients.

Hamostaseologie 2019 Feb 9;39(1):6-19. Epub 2019 Jan 9.

Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1055/s-0038-1676823DOI Listing
February 2019

Natural, not immune; classical, not alternative.

Blood 2018 Dec;132(23):2421-2422

McMaster University.

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http://dx.doi.org/10.1182/blood-2018-10-880799DOI Listing
December 2018

Neutropenia and monocytopenia in recurrent anaphylactoid reactions after red blood cell transfusions in a woman with immunoglobulin A (IgA) deficiency and anti-IgA.

Transfusion 2018 10 4;58(10):2320-2325. Epub 2018 Sep 4.

Department of Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1111/trf.14894DOI Listing
October 2018

Systematic review of fondaparinux for heparin-induced thrombocytopenia: When there are no randomized controlled trials.

Res Pract Thromb Haemost 2018 Oct 9;2(4):678-683. Epub 2018 Aug 9.

Department of Medicine Michael G. DeGroote School of Medicine McMaster University Hamilton Ontario Canada.

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http://doi.wiley.com/10.1002/rth2.12145
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http://dx.doi.org/10.1002/rth2.12145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178656PMC
October 2018

High sensitivity and specificity of an automated IgG-specific chemiluminescence immunoassay for diagnosis of HIT.

Blood 2018 Sep 31;132(12):1345-1349. Epub 2018 Jul 31.

Department of Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada.

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http://dx.doi.org/10.1182/blood-2018-04-847483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202723PMC
September 2018

Platelet-Activating Antibodies Are Detectable at the Earliest Onset of Heparin-Induced Thrombocytopenia, With Implications for the Operating Characteristics of the Serotonin-Release Assay.

Chest 2018 Jun 8;153(6):1396-1404. Epub 2018 Jan 8.

Department of Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada; McMaster Centre for Transfusion Research, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada.

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http://dx.doi.org/10.1016/j.chest.2018.01.001DOI Listing
June 2018

Intravenous Immune Globulin to Prevent Heparin-Induced Thrombocytopenia.

N Engl J Med 2018 05;378(19):1845-1848

McMaster University, Hamilton, ON, Canada

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http://dx.doi.org/10.1056/NEJMc1801799DOI Listing
May 2018

Levofloxacin-Induced Acute Immune-Mediated Thrombocytopenia of Rapid-Onset.

J Pharm Pract 2018 Apr 13;31(2):234-237. Epub 2017 Apr 13.

1 Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1177/0897190017702306DOI Listing
April 2018

Fondaparinux for Treatment of Heparin-Induced Thrombocytopenia: Too Good to Be True?

J Am Coll Cardiol 2017 11;70(21):2649-2651

Department of Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada; and the Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2017.09.1098DOI Listing
November 2017

Platelet count recovery and seroreversion in immune HIT despite continuation of heparin: further observations and literature review.

Thromb Haemost 2017 10 24;117(10):1868-1874. Epub 2017 Aug 24.

Andrew Shih, MD, FRCPC, DRCPSC, BSc, Vancouver General Hospital, Department of Pathology, JPP1, room 1553, 855 West 12th Avenue, Vancouver, B. C. V5Z 1M9, Canada, Tel.: +1 604 875 4111 Ext. 61109, E-mail:

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http://dx.doi.org/10.1160/TH17-03-0212DOI Listing
October 2017

Spontaneous HIT syndrome post-knee replacement surgery with delayed recovery of thrombocytopenia: a case report and literature review.

Platelets 2017 Sep 31;28(6):614-620. Epub 2017 Aug 31.

b Department of Pathology and Molecular Medicine, and Department of Medicine , Michael G. DeGroote School of Medicine, McMaster University , Hamilton , Ontario , Canada.

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http://dx.doi.org/10.1080/09537104.2017.1366973DOI Listing
September 2017

IV Immunoglobulin for Autoimmune Heparin-Induced Thrombocytopenia.

Chest 2017 09;152(3):453-455

Department of Medicine (Division of Hematology and Thromboembolism), Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada; Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada; McMaster Centre for Transfusion Research, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.chest.2017.05.042DOI Listing
September 2017

Direct oral anticoagulants for treatment of HIT: update of Hamilton experience and literature review.

Blood 2017 08 23;130(9):1104-1113. Epub 2017 Jun 23.

Department of Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada.

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http://dx.doi.org/10.1182/blood-2017-04-778993DOI Listing
August 2017

Apixaban for treatment of confirmed heparin-induced thrombocytopenia: a case report and review of literature.

Exp Hematol Oncol 2017 14;6:21. Epub 2017 Jul 14.

Department of Hematology and Oncology, William Beaumont Hospital, Oakland University William Beaumont School of Medicine, 3577 W. 13 Mile Rd., Suite 202a, Royal Oak, MI USA.

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http://dx.doi.org/10.1186/s40164-017-0080-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513338PMC
July 2017

Performance characteristics of an automated latex immunoturbidimetric assay [HemosIL HIT-Ab] for the diagnosis of immune heparin-induced thrombocytopenia.

Thromb Res 2017 May 11;153:108-117. Epub 2017 Mar 11.

Department of Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada; McMaster Centre for Transfusion Research, Hamilton, Ontario, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S00493848173023
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http://dx.doi.org/10.1016/j.thromres.2017.03.010DOI Listing
May 2017

How do we approach thrombocytopenia in critically ill patients?

Br J Haematol 2017 04 16;177(1):27-38. Epub 2016 Dec 16.

Department of Pathology and Molecular Medicine, McMaster University, Hamilton Regional Laboratory Medicine Program, Hamilton General Hospital, Hamilton Health Sciences, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1111/bjh.14482DOI Listing
April 2017

Sepsis and persisting neutropenia in a drug addict.

Am J Hematol 2017 Mar 3;92(3):312-316. Epub 2017 Feb 3.

Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1002/ajh.24639DOI Listing
March 2017

Effect of Short-Term vs. Long-Term Blood Storage on Mortality after Transfusion.

N Engl J Med 2016 11 24;375(20):1937-1945. Epub 2016 Oct 24.

From the Departments of Medicine (N.M.H., D.M.A., Y.L., R.B., M.A.C., P.J.D., J.H., T.E.W., J.W.E.), Pathology and Molecular Medicine (N.M.H., M.A.C., T.E.W., K.E.W.), and Clinical Epidemiology and Biostatistics (N.M.H., P.J.D.) and McMaster Centre for Transfusion Research (N.M.H., R.J.C., D.M.A., Y.L., R.B., T.E.W., K.E.W.), McMaster University, Canadian Blood Services (N.M.H., D.M.A., K.E.W.), the Population Health Research Institute (P.J.D., J.W.E.), and the Thrombosis and Atherosclerosis Research Institute (J.W.E.), Hamilton, ON, and the Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, ON (R.J.C.) - all in Canada; SA Pathology Transfusion Service, Flinders Medical Centre and Flinders University, Adelaide, SA, Australia (D.R., M.S.-T.); the Departments of General Anesthesiology (A.K.) and Outcomes Research (A.K., D.I.S.), Anesthesiology Institute, and the Robert J. Tomsich Pathology and Laboratory Medicine Institute and the Department of Laboratory Medicine (P.F.), Cleveland Clinic, Cleveland; and Meir Medical Center Kfar Saba and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel (M.E.).

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http://dx.doi.org/10.1056/NEJMoa1609014DOI Listing
November 2016

Acute intraoperative HIT during heart surgery: Why so rare?

Thromb Res 2016 Oct 12;146:110-112. Epub 2016 Sep 12.

Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada; Department of Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.thromres.2016.09.005DOI Listing
October 2016

Clinical picture of heparin-induced thrombocytopenia (HIT) and its differentiation from non-HIT thrombocytopenia.

Thromb Haemost 2016 Oct 22;116(5):813-822. Epub 2016 Sep 22.

Prof. Theodore (Ted) E. Warkentin, Hamilton Regional Laboratory Medicine Program, Room 1-270B, Hamilton General Hospital, 237 Barton St. E., Hamilton, Ontario L8L 2X2, Canada, Tel.: +1 905 527 0271 ext. 46139, Fax: +1 905 577 1421, E-mail:

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http://dx.doi.org/10.1160/TH16-06-0435DOI Listing
October 2016

Heparin-induced thrombocytopenia in 2017 and beyond.

Thromb Haemost 2016 10 13;116(5):781-782. Epub 2016 Oct 13.

Tamam Bakchoul, MD, Center for Clinical Transfusion Medicine, University Hospital of Tübingen, Otfried-Müller-Straße 4/1, 72076 Tübingen, Germany, Tel.: +49 7071 29 81601, Fax: +49 7071 29 5240, E-mail:

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http://dx.doi.org/10.1160/TH16-09-0742DOI Listing
October 2016

B cells, PF4/heparin complexes, and complement.

Blood 2016 10;128(14):1781-1782

MCMASTER UNIVERSITY.

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http://dx.doi.org/10.1182/blood-2016-08-729517DOI Listing
October 2016

Management of heparin-induced thrombocytopenia.

Curr Opin Hematol 2016 09;23(5):462-70

aDepartment of Pathology and Molecular Medicine; Department of Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada bInstitut für Immunologie und Transfusionsmedizin, Universitätsmedizin Greifswald, Greifswald, Germany.

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http://dx.doi.org/10.1097/MOH.0000000000000273DOI Listing
September 2016

Platelet Activation Testing for Heparin-Induced Thrombocytopenia Antibodies: A Problem That Needs Fixing?

Chest 2016 09;150(3):478-80

Department of Pathology and Molecular Medicine, and the Department of Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.chest.2016.04.001DOI Listing
September 2016

Letter of response to Peters and Vlaar commentary.

Transfusion 2016 09;56(9):2395-7

Ruhr University, Bochum, Germany.

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http://dx.doi.org/10.1111/trf.13747DOI Listing
September 2016

Difficulties in establishing the diagnosis of immune thrombocytopenia: An agreement study.

Am J Hematol 2016 08 1;91(8):E327-9. Epub 2016 Jun 1.

Department of Medicine, Michael G. DeGroote School of Medicine, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1002/ajh.24404DOI Listing
August 2016

Safe bridging to warfarin in heparin-induced thrombocytopenia.

Thromb Res 2016 Aug 23;144:226-8. Epub 2016 Jun 23.

Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada; Department of Medicine, McMaster University, Hamilton, ON, Canada.

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http://dx.doi.org/10.1016/j.thromres.2016.06.025DOI Listing
August 2016

How I treat patients with a history of heparin-induced thrombocytopenia.

Blood 2016 07 25;128(3):348-59. Epub 2016 Apr 25.

Department of Haematology, Royal Infirmary of Edinburgh, and College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, United Kingdom.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2016-01-63
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http://dx.doi.org/10.1182/blood-2016-01-635003DOI Listing
July 2016

Demand on-demand testing for the diagnosis of heparin-induced thrombocytopenia.

Thromb Res 2016 Apr 18;140:163-164. Epub 2016 Feb 18.

Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada; Department of Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.thromres.2016.02.015DOI Listing
April 2016

Knee replacement and HIT without heparin.

Blood 2016 Feb;127(8):961-2

MCMASTER UNIVERSITY.

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http://dx.doi.org/10.1182/blood-2015-12-687665DOI Listing
February 2016

Heparin-induced thrombocytopenia.

Curr Opin Crit Care 2015 Dec;21(6):576-85

aDepartment of Pathology and Molecular Medicine bDepartment of Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1097/MCC.0000000000000259DOI Listing
December 2015

Ischemic Limb Gangrene with Pulses.

N Engl J Med 2015 12;373(24):2386-8

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http://dx.doi.org/10.1056/NEJMc1511750DOI Listing
December 2015

Progressive, Fatal Thrombosis Associated With Heparin-Induced Thrombocytopenia After Cardiac Surgery Despite "Therapeutic" Anticoagulation With Argatroban: Potential Role for PTT and ACT Confounding.

J Cardiothorac Vasc Anesth 2015 Oct 29;29(5):1319-21. Epub 2014 Aug 29.

Cardiovascular Research and Quality Programs, Ernst Cardiovascular Center, Beaumont Hospital, Royal Oak, MI.

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http://dx.doi.org/10.1053/j.jvca.2014.04.029DOI Listing
October 2015

Non-injection-site necrotic skin lesions complicating postoperative heparin thromboprophylaxis.

Am J Hematol 2015 Aug;90(8):747-50

Department of Pathology and Molecular Medicine, Michael G, DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1002/ajh.24018DOI Listing
August 2015

Ischemic Limb Gangrene with Pulses.

N Engl J Med 2015 Aug;373(7):642-55

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http://dx.doi.org/10.1056/NEJMra1316259DOI Listing
August 2015

The Role for Optical Density in Heparin-Induced Thrombocytopenia: A Cohort Study.

Chest 2015 Jul;148(1):55-61

Pulmonary and Critical Care Section, MedStar Washington Hospital Center, and Georgetown University Medical Center, Washington, DC.

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http://dx.doi.org/10.1378/chest.14-1417DOI Listing
July 2015

Pitfalls in the diagnosis of heparin-Induced thrombocytopenia: A 6-year experience from a reference laboratory.

Am J Hematol 2015 Jul 3;90(7):629-33. Epub 2015 May 3.

Department of Medicine. Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1002/ajh.24025DOI Listing
July 2015

Combination of 4Ts score and PF4/H-PaGIA for diagnosis and management of heparin-induced thrombocytopenia: prospective cohort study.

Blood 2015 Jul 29;126(5):597-603. Epub 2015 Apr 29.

Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada.

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http://dx.doi.org/10.1182/blood-2014-12-618165DOI Listing
July 2015

Warfarin-induced venous limb ischemia/gangrene complicating cancer: a novel and clinically distinct syndrome.

Blood 2015 Jul 15;126(4):486-93. Epub 2015 May 15.

Department of Pathology and Molecular Medicine, and Department of Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada;

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2015-01-62
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http://dx.doi.org/10.1182/blood-2015-01-622787DOI Listing
July 2015

The platelet serotonin-release assay.

Am J Hematol 2015 Jun 3;90(6):564-72. Epub 2015 May 3.

Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1002/ajh.24006DOI Listing
June 2015

The transfusion-related acute lung injury controversy: lessons from heparin-induced thrombocytopenia.

Transfusion 2015 May 3;55(5):1128-34. Epub 2015 Feb 3.

Ruhr University, Bochum, Germany.

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http://dx.doi.org/10.1111/trf.12994DOI Listing
May 2015

Scoring systems for heparin-induced thrombocytopenia (HIT): whither now?

Thromb Haemost 2015 Mar 15;113(3):437-8. Epub 2015 Jan 15.

Dr. T. Warkentin, Hamilton Regional Laboratory Medicine Program, Room 1-180A, Hamilton Health Sciences (Hamilton General Site), 237 Barton St. E., Hamilton, Ontario, L8L 2X2, Canada, Tel: +1 905 527 0271, Fax: +1 905 577 1421, E-mail:

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http://dx.doi.org/10.1160/TH14-11-0974DOI Listing
March 2015

4Ts scoring with hemofiltration or hemodialysis clotting.

J Clin Monit Comput 2015 Feb;29(1):7-9

Hamilton Regional Laboratory Medicine Program, Hamilton Health Sciences, Hamilton General Hospital, 237 Barton St. E., Hamilton, ON, L8L 2X2, Canada,

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http://dx.doi.org/10.1007/s10877-014-9594-2DOI Listing
February 2015

Immature platelet count: part of the cardiologist's complete blood count?

J Am Coll Cardiol 2014 Nov 18-25;64(20):2130-2. Epub 2014 Nov 10.

Department of Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada; Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1016/j.jacc.2014.09.014DOI Listing
February 2015

Failure of anticoagulant thromboprophylaxis: risk factors in medical-surgical critically ill patients*.

Crit Care Med 2015 Feb;43(2):401-10

1Department of Medicine, McMaster University, Hamilton, ON, Canada. 2Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada. 3Research Center of the CHU de Québec, Population Health and Optimal Health Practices Research Unit, Québec, QC, Canada. 4Division of Critical Care, Department of Medicine, Québec, QC, Canada. 5Section of Critical Care, Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada. 6Section of Hematology/Medical Oncology, Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada. 7Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada. 8Division of Critical Care, Department of Medicine, Centre de Recherche Clinique Étiene-Le Bel, Université de Sherbrooke, Sherbrooke, QC, Canada. 9Division of Critical Care Medicine and Center for Health Evaluation and Outcome Sciences, St. Paul's Hospital and University of British Columbia, Vancouver, BC, Canada. 10Department of Critical Care, University of Ottawa, Ottawa, ON, Canada. 11Department of Anesthesia, Queen Elizabeth II Health Sciences Centre, 12Department of Critical Care, Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada. 13Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada. 14Department of Medicine, Queen's University, Kingston, ON, Canada. 15Department of Anesthesiology, Québec, QC, Canada. 16Department of Medicine, University of Toronto, Toronto, ON, Canada. 17Malcolm Fisher Department of Intensive Care Medicine, Royal North Shore Hospital, Sydney, Australia. 18The George Institute for Global Health, University of Sydney, Sydney, Australia. 19Department of Critical Care, University of Alberta, Edmonton, AB, Canada. 20Department of Anesthesia, University of Alberta, Edmonton, AB, Canada. 21Department of Medicine, Research Institute-HCor, Hospital do Coracao, Sao Paolo, Brazil. 22Department of Intensive Care Medicine, Guys

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http://dx.doi.org/10.1097/CCM.0000000000000713DOI Listing
February 2015

Heparin-induced thrombocytopenia in critically ill patients.

Semin Thromb Hemost 2015 Feb 15;41(1):49-60. Epub 2015 Jan 15.

Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0034-1398381
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http://dx.doi.org/10.1055/s-0034-1398381DOI Listing
February 2015

Rivaroxaban for treatment of HIT: a riveting first experience.

Thromb Res 2015 Jan 1;135(1):1-2. Epub 2014 Nov 1.

Department of Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada; Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.thromres.2014.10.019DOI Listing
January 2015

Heparin-induced thrombocytopenia presenting as bilateral adrenal hemorrhages.

N Engl J Med 2015 Jan;372(5):492-4

McMaster University, Hamilton, ON, Canada

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http://dx.doi.org/10.1056/NEJMc1414161DOI Listing
January 2015

Design of the rivaroxaban for heparin-induced thrombocytopenia study.

J Thromb Thrombolysis 2014 Nov;38(4):485-92

Department of Medicine, McMaster University, 1280 Main Street West, Juravinski Hospital Site, Rm A3-74, Hamilton, ON, L8S 4K1, Canada,

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http://dx.doi.org/10.1007/s11239-014-1064-7DOI Listing
November 2014

Progressive thrombocytopenia after cardiac surgery in a 67-year-old man.

CMAJ 2014 Sep 22;186(12):929-33. Epub 2014 Apr 22.

Department of Medicine (Kopolovic), University of Toronto, Toronto, Ont.; Pathology and Molecular Medicine (Warkentin), Hamilton Regional Laboratory Medicine Program, McMaster University, Hamilton, Ont.

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http://dx.doi.org/10.1503/cmaj.131449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150708PMC
September 2014

Voting with your fondaparinux.

Thromb Res 2014 Jul 1;134(1):3-4. Epub 2014 Apr 1.

Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada; Department of Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.thromres.2014.03.045DOI Listing
July 2014

Platelet microparticle generation assay for detection of HIT antibodies: advance, retreat, or too soon to tell?

Thromb Res 2014 Jun 5;133(6):957-8. Epub 2014 Jan 5.

Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada; Department of Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.thromres.2013.12.040DOI Listing
June 2014

An instrument-based immunoassay with an appropriate normal range: minimizing HIT overdiagnosis.

Thromb Res 2014 Jun 28;133(6):961-2. Epub 2014 Jan 28.

Department of Pathology and Molecular Medicine, and Department of Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.thromres.2014.01.028DOI Listing
June 2014

Spontaneous heparin-induced thrombocytopenia syndrome: 2 new cases and a proposal for defining this disorder.

Blood 2014 Jun 27;123(23):3651-4. Epub 2014 Mar 27.

Ken and Ruth Davee Department of Neurology and Clinical Neurological Sciences, Feinberg School of Medicine of Northwestern University, Chicago, IL.

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http://dx.doi.org/10.1182/blood-2014-01-549741DOI Listing
June 2014

Serological investigation of patients with a previous history of heparin-induced thrombocytopenia who are reexposed to heparin.

Blood 2014 Apr 10;123(16):2485-93. Epub 2014 Feb 10.

Department of Pathology and Molecular Medicine and.

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http://dx.doi.org/10.1182/blood-2013-10-533083DOI Listing
April 2014

Anticoagulant failure in coagulopathic patients: PTT confounding and other pitfalls.

Expert Opin Drug Saf 2014 Jan 23;13(1):25-43. Epub 2013 Aug 23.

Department of Pathology and Molecular Medicine, McMaster University, Hamilton Regional Laboratory Medicine Program, Hamilton General Hospital, Hamilton Health Sciences , 237 Barton St. E, Hamilton, Ontario L8L 2X2 , Canada

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http://dx.doi.org/10.1517/14740338.2013.823946DOI Listing
January 2014

Improving clinical interpretation of the anti-platelet factor 4/heparin enzyme-linked immunosorbent assay for the diagnosis of heparin-induced thrombocytopenia through the use of receiver operating characteristic analysis, stratum-specific likelihood ratios, and Bayes theorem.

Chest 2013 Oct;144(4):1269-1275

Department of Medical Education, Banner Good Samaritan Medical Center, Phoenix, AZ; Department of Medicine, University of Arizona College of Medicine, Phoenix, AZ.

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http://dx.doi.org/10.1378/chest.12-2712DOI Listing
October 2013

Approach to the diagnosis and management of drug-induced immune thrombocytopenia.

Transfus Med Rev 2013 Jul 8;27(3):137-45. Epub 2013 Jul 8.

Michael G. DeGroote School of Medicine, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1016/j.tmrv.2013.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728035PMC
July 2013

Anti-protamine-heparin antibodies: incidence, clinical relevance, and pathogenesis.

Blood 2013 Apr 16;121(15):2821-7. Epub 2013 Jan 16.

Institute for Immunology und Transfusion Medicine, Ernst-Moritz-Arndt University Greifswald, Germany.

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http://dx.doi.org/10.1182/blood-2012-10-460691DOI Listing
April 2013

Predictive value of the 4Ts scoring system for heparin-induced thrombocytopenia: a systematic review and meta-analysis.

Blood 2012 Nov 18;120(20):4160-7. Epub 2012 Sep 18.

Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1182/blood-2012-07-443051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501714PMC
November 2012

Aspirin for dual prevention of venous and arterial thrombosis.

N Engl J Med 2012 Nov 4;367(21):2039-41. Epub 2012 Nov 4.

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http://www.nejm.org/doi/abs/10.1056/NEJMe1211480
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http://dx.doi.org/10.1056/NEJMe1211480DOI Listing
November 2012

Heparin-induced thrombocytopenia in the ICU: a transatlantic perspective.

Chest 2012 Oct;142(4):815-816

Department of Pathology and Molecular Medicine, and Department of Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada; Hamilton Regional Laboratory Medicine Program, Hamilton, ON, Canada; Hamilton Health Sciences, Hamilton General Hospital, Hamilton, ON, Canada. Electronic address:

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http://dx.doi.org/10.1378/chest.12-0979DOI Listing
October 2012

Acute hepatic necrosis and ischemic limb necrosis.

N Engl J Med 2012 Aug;367(9):879-81

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http://dx.doi.org/10.1056/NEJMc1207074DOI Listing
August 2012

Reversing anticoagulant therapy.

Curr Drug Discov Technol 2012 Jun;9(2):143-9

Department of Medicine, Michael G. DeGroote School of Medicine, McMaster University, L301-50 Charlton Ave East Hamilton, Ontario L8N 4A6, Canada.

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June 2012

The effect of blood storage duration on in-hospital mortality: a randomized controlled pilot feasibility trial.

Transfusion 2012 Jun 18;52(6):1203-12. Epub 2012 Jan 18.

Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1111/j.1537-2995.2011.03521.xDOI Listing
June 2012

HITlights: a career perspective on heparin-induced thrombocytopenia.

Am J Hematol 2012 May 24;87 Suppl 1:S92-9. Epub 2012 Feb 24.

Department of Pathology and Molecular Medicine, Michael G DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://doi.wiley.com/10.1002/ajh.23127
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http://dx.doi.org/10.1002/ajh.23127DOI Listing
May 2012

How I diagnose and manage HIT.

Hematology Am Soc Hematol Educ Program 2011 ;2011:143-9

Department of Pathology and Molecular Medicine, Michael G DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada.

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http://www.asheducationbook.org/cgi/doi/10.1182/asheducation
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http://dx.doi.org/10.1182/asheducation-2011.1.143DOI Listing
April 2012

Storage of thawed plasma for a liquid plasma bank: impact of temperature and methylene blue pathogen inactivation.

Transfusion 2012 Mar 31;52(3):529-36. Epub 2011 Aug 31.

Institut für Immunologie und Transfusionsmedizin, Ernst-Moritz-Arndt Universität, Greifswald, Germany.

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http://dx.doi.org/10.1111/j.1537-2995.2011.03317.xDOI Listing
March 2012

HIT: treatment easier, prevention harder.

Blood 2012 Feb;119(5):1099-100

McMaster University.

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http://dx.doi.org/10.1182/blood-2011-11-391284DOI Listing
February 2012

Prognostic importance of preoperative anti-PF4/heparin antibodies in patients undergoing cardiac surgery. A systematic review.

Thromb Haemost 2012 Jan 10;107(1):8-14. Epub 2011 Nov 10.

Population Health Research Institute, 237 Barton St. E. Hamilton, ON L8L 2X2, Canada.

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http://dx.doi.org/10.1160/TH11-07-0480DOI Listing
January 2012

A novel sickling hemoglobinopathy.

N Engl J Med 2011 Oct;365(16):1548-9

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http://dx.doi.org/10.1056/NEJMc1109418DOI Listing
October 2011

Heparin-induced thrombocytopenia in critically ill patients.

Crit Care Clin 2011 Oct;27(4):805-23, v

Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.

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http://dx.doi.org/10.1016/j.ccc.2011.08.001DOI Listing
October 2011

Heparin-induced thrombocytopenia: real-world issues.

Semin Thromb Hemost 2011 Sep 18;37(6):653-63. Epub 2011 Nov 18.

Department of Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1055/s-0031-1291375DOI Listing
September 2011