Theodore C Pierson

Theodore C Pierson

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Effects of dengue immunity on Zika virus infection.

Nature 2019 03;567(7749):467-468

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http://dx.doi.org/10.1038/d41586-019-00868-6DOI Listing
March 2019

Dengue and Zika Virus Cross-Reactive Human Monoclonal Antibodies Protect against Spondweni Virus Infection and Pathogenesis in Mice.

Cell Rep 2019 02;26(6):1585-1597.e4

Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA; Department of Pathology & Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA; Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63110, USA; The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, Saint Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.01.052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420780PMC
February 2019

Zika Virus Vaccine Development: Progress in the Face of New Challenges.

Annu Rev Med 2019 01 2;70:121-135. Epub 2018 Nov 2.

Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA; email:

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https://www.annualreviews.org/doi/10.1146/annurev-med-040717
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http://dx.doi.org/10.1146/annurev-med-040717-051127DOI Listing
January 2019

An mRNA Vaccine Protects Mice against Multiple Tick-Transmitted Flavivirus Infections.

Cell Rep 2018 12;25(12):3382-3392.e3

Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA; The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183187
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http://dx.doi.org/10.1016/j.celrep.2018.11.082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353567PMC
December 2018

Cross-Reactive Flavivirus Antibody: Friend and Foe?

Cell Host Microbe 2018 11;24(5):622-624

Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2018.10.016DOI Listing
November 2018

The Many Faces of a Dynamic Virion: Implications of Viral Breathing on Flavivirus Biology and Immunogenicity.

Annu Rev Virol 2018 09;5(1):185-207

Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA; email: ,

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https://www.annualreviews.org/doi/10.1146/annurev-virology-0
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http://dx.doi.org/10.1146/annurev-virology-092917-043300DOI Listing
September 2018

The emergence of Zika virus and its new clinical syndromes.

Nature 2018 08 29;560(7720):573-581. Epub 2018 Aug 29.

Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.

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http://www.nature.com/articles/s41586-018-0446-y
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http://dx.doi.org/10.1038/s41586-018-0446-yDOI Listing
August 2018

A VSV-based Zika virus vaccine protects mice from lethal challenge.

Sci Rep 2018 07 23;8(1):11043. Epub 2018 Jul 23.

Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.

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http://dx.doi.org/10.1038/s41598-018-29401-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056530PMC
July 2018

The Zika virus envelope protein glycan loop regulates virion antigenicity.

Virology 2018 02 2;515:191-202. Epub 2018 Jan 2.

Viral Pathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.virol.2017.12.032DOI Listing
February 2018

Inhibitors of the Histone Methyltransferases EZH2/1 Induce a Potent Antiviral State and Suppress Infection by Diverse Viral Pathogens.

mBio 2017 08 15;8(4). Epub 2017 Aug 15.

Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

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http://dx.doi.org/10.1128/mBio.01141-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559635PMC
August 2017

Vaccine Mediated Protection Against Zika Virus-Induced Congenital Disease.

Cell 2017 Jul;170(2):273-283.e12

Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA; The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674173075
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http://dx.doi.org/10.1016/j.cell.2017.06.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546158PMC
July 2017

Modified mRNA Vaccines Protect against Zika Virus Infection.

Cell 2017 03 17;168(6):1114-1125.e10. Epub 2017 Feb 17.

Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA; The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.02.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388441PMC
March 2017

A single mutation in the envelope protein modulates flavivirus antigenicity, stability, and pathogenesis.

PLoS Pathog 2017 02 16;13(2):e1006178. Epub 2017 Feb 16.

Viral Pathogenesis Section, National Institutes of Health, Bethesda, MD, United States of America.

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https://dx.plos.org/10.1371/journal.ppat.1006178
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http://dx.doi.org/10.1371/journal.ppat.1006178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312798PMC
February 2017

T Cells Take on Zika Virus.

Immunity 2017 01;46(1):13-14

Laboratory of Viral Diseases, National Institutes of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2016.12.020DOI Listing
January 2017

Deconstructing the Antiviral Neutralizing-Antibody Response: Implications for Vaccine Development and Immunity.

Microbiol Mol Biol Rev 2016 12 26;80(4):989-1010. Epub 2016 Oct 26.

Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

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http://dx.doi.org/10.1128/MMBR.00024-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116878PMC
December 2016

Enhancing dengue virus maturation using a stable furin over-expressing cell line.

Virology 2016 10 13;497:33-40. Epub 2016 Jul 13.

Viral Pathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.virol.2016.06.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502530PMC
October 2016

Zika Virus: Immunity and Vaccine Development.

Cell 2016 Oct 29;167(3):625-631. Epub 2016 Sep 29.

Viral Pathogenesis Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5074878PMC
http://dx.doi.org/10.1016/j.cell.2016.09.020DOI Listing
October 2016

Zika Virus Is Not Uniquely Stable at Physiological Temperatures Compared to Other Flaviviruses.

mBio 2016 09 6;7(5). Epub 2016 Sep 6.

Viral Pathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

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http://dx.doi.org/10.1128/mBio.01396-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013301PMC
September 2016

Zika in the Brain: New Models Shed Light on Viral Infection.

Trends Mol Med 2016 08 23;22(8):639-641. Epub 2016 Jun 23.

Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2016.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990132PMC
August 2016

Structural Basis of Zika Virus-Specific Antibody Protection.

Cell 2016 Aug 27;166(4):1016-1027. Epub 2016 Jul 27.

Department of Pathology & Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA; Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63110, USA; Department of Biochemistry & Molecular Biophysics, Washington University School of Medicine, Saint Louis, MO 63110, USA; The Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, Saint Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.07.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983199PMC
August 2016

Broadly Neutralizing Activity of Zika Virus-Immune Sera Identifies a Single Viral Serotype.

Cell Rep 2016 08 29;16(6):1485-1491. Epub 2016 Jul 29.

Viral Pathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.07.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004740PMC
August 2016

VIROLOGY. Diagnostics for Zika virus on the horizon.

Science 2016 Aug;353(6301):750-1

Viral Pathogenesis Section, National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1126/science.aah6187DOI Listing
August 2016

The 3.8 Å resolution cryo-EM structure of Zika virus.

Science 2016 Apr 31;352(6284):467-70. Epub 2016 Mar 31.

Markey Center for Structural Biology and Purdue Institute for Inflammation, Immunology and Infectious Disease, Purdue University, West Lafayette, IN 47907, USA.

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http://dx.doi.org/10.1126/science.aaf5316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845755PMC
April 2016

Genotypic Differences in Dengue Virus Neutralization Are Explained by a Single Amino Acid Mutation That Modulates Virus Breathing.

mBio 2015 Nov 3;6(6):e01559-15. Epub 2015 Nov 3.

Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

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http://dx.doi.org/10.1128/mBio.01559-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631804PMC
November 2015

Dengue viruses cluster antigenically but not as discrete serotypes.

Science 2015 Sep;349(6254):1338-43

Center for Pathogen Evolution, Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK. World Health Organization (WHO) Collaborating Center for Modeling, Evolution, and Control of Emerging Infectious Diseases, Cambridge CB2 3EJ, UK. Department of Viroscience, Erasmus MC, Rotterdam 3015 GE, Netherlands.

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http://dx.doi.org/10.1126/science.aac5017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876809PMC
September 2015

A game of numbers: the stoichiometry of antibody-mediated neutralization of flavivirus infection.

Prog Mol Biol Transl Sci 2015 1;129:141-66. Epub 2014 Dec 1.

Departments of Medicine, Molecular Microbiology, Pathology & Immunology, Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, Missouri, USA. Electronic address:

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http://dx.doi.org/10.1016/bs.pmbts.2014.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910618PMC
August 2015

Context-Dependent Cleavage of the Capsid Protein by the West Nile Virus Protease Modulates the Efficiency of Virus Assembly.

J Virol 2015 Aug 10;89(16):8632-42. Epub 2015 Jun 10.

Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

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http://dx.doi.org/10.1128/JVI.01253-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4524226PMC
August 2015

Dengue virus: Bumps in the road to therapeutic antibodies.

Nature 2015 Aug;524(7565):295-6

Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/524295aDOI Listing
August 2015

Molecular Insight into Dengue Virus Pathogenesis and Its Implications for Disease Control.

Cell 2015 Jul;162(3):488-92

Viral Pathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.07.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522276PMC
July 2015

Shake, rattle, and roll: Impact of the dynamics of flavivirus particles on their interactions with the host.

Virology 2015 May 30;479-480:508-17. Epub 2015 Mar 30.

Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00426822150016
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http://dx.doi.org/10.1016/j.virol.2015.03.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900690PMC
May 2015

Pseudo-infectious reporter virus particles for measuring antibody-mediated neutralization and enhancement of dengue virus infection.

Methods Mol Biol 2014 ;1138:75-97

Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1007/978-1-4939-0348-1_6DOI Listing
November 2014

Vaccine Development as a Means to Control Dengue Virus Pathogenesis: Do We Know Enough?

Annu Rev Virol 2014 Nov 27;1(1):375-98. Epub 2014 Jun 27.

Departments of Medicine, Molecular Microbiology, and Pathology & Immunology, Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, Missouri 63110; email:

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http://dx.doi.org/10.1146/annurev-virology-031413-085453DOI Listing
November 2014

Combined effects of the structural heterogeneity and dynamics of flaviviruses on antibody recognition.

J Virol 2014 Oct 30;88(20):11726-37. Epub 2014 Jul 30.

Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

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http://dx.doi.org/10.1128/JVI.01140-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178732PMC
October 2014

The type-specific neutralizing antibody response elicited by a dengue vaccine candidate is focused on two amino acids of the envelope protein.

PLoS Pathog 2013 5;9(12):e1003761. Epub 2013 Dec 5.

Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1003761DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857832PMC
September 2014

Potent dengue virus neutralization by a therapeutic antibody with low monovalent affinity requires bivalent engagement.

PLoS Pathog 2014 Apr 17;10(4):e1004072. Epub 2014 Apr 17.

Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, United States of America; Department of Biochemistry & Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1004072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3990716PMC
April 2014

Nucleolin interacts with the dengue virus capsid protein and plays a role in formation of infectious virus particles.

J Virol 2013 Dec 11;87(24):13094-106. Epub 2013 Sep 11.

Cytokine Biology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1128/JVI.00704-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838225PMC
December 2013

The Fc region of an antibody impacts the neutralization of West Nile viruses in different maturation states.

J Virol 2013 Dec 9;87(24):13729-40. Epub 2013 Oct 9.

Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA.

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http://jvi.asm.org/cgi/doi/10.1128/JVI.02340-13
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http://dx.doi.org/10.1128/JVI.02340-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838241PMC
December 2013

Structural basis of differential neutralization of DENV-1 genotypes by an antibody that recognizes a cryptic epitope.

PLoS Pathog 2012 4;8(10):e1002930. Epub 2012 Oct 4.

Department of Pathology & Immunology, Washington University School of Medicine, Saint Louis, Missouri, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1002930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464233PMC
April 2013

Impact of viral attachment factor expression on antibody-mediated neutralization of flaviviruses.

Virology 2013 Mar 10;437(1):20-7. Epub 2013 Jan 10.

Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institute of Allergy & Infectious Diseases, NIH, Bethesda, MD 20852, USA.

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http://dx.doi.org/10.1016/j.virol.2012.11.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601793PMC
March 2013

Flaviviruses: braking the entering.

Curr Opin Virol 2013 Feb 24;3(1):3-12. Epub 2013 Jan 24.

Viral Pathogenesis Section, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, United States.

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http://dx.doi.org/10.1016/j.coviro.2012.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601797PMC
February 2013

Measles immunometrics.

Proc Natl Acad Sci U S A 2012 Sep 30;109(37):14724-5. Epub 2012 Aug 30.

Laboratory of Viral Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1073/pnas.1212243109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443159PMC
September 2012

Ago-2-mediated slicer activity is essential for anti-flaviviral efficacy of RNAi.

PLoS One 2011 10;6(11):e27551. Epub 2011 Nov 10.

Department of Biomedical Sciences, Center of Excellence in Infectious Disease Research, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0027551PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3213142PMC
May 2012

A novel approach for the rapid mutagenesis and directed evolution of the structural genes of west nile virus.

J Virol 2012 Apr 18;86(7):3501-12. Epub 2012 Jan 18.

Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1128/JVI.06435-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302547PMC
April 2012

Degrees of maturity: the complex structure and biology of flaviviruses.

Curr Opin Virol 2012 Apr 23;2(2):168-75. Epub 2012 Mar 23.

Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, United States.

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http://dx.doi.org/10.1016/j.coviro.2012.02.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3715965PMC
April 2012

Capturing a virus while it catches its breath.

Structure 2012 Feb;20(2):200-2

Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.str.2012.01.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3733089PMC
February 2012

The infectivity of prM-containing partially mature West Nile virus does not require the activity of cellular furin-like proteases.

J Virol 2011 Nov 31;85(22):12067-72. Epub 2011 Aug 31.

Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institutes of Health, 33 North Drive, Building 33, Room 2E19A.2, Bethesda, MD 20892, USA.

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http://jvi.asm.org/content/85/22/12067.full.pdf
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http://jvi.asm.org/content/early/2011/08/31/JVI.05559-11.ful
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http://jvi.asm.org/cgi/doi/10.1128/JVI.05559-11
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http://dx.doi.org/10.1128/JVI.05559-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3209279PMC
November 2011

Poorly neutralizing cross-reactive antibodies against the fusion loop of West Nile virus envelope protein protect in vivo via Fcgamma receptor and complement-dependent effector mechanisms.

J Virol 2011 Nov 14;85(22):11567-80. Epub 2011 Sep 14.

Department of Pathology & Immunology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8051, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1128/JVI.05859-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3209272PMC
November 2011

A dynamic landscape for antibody binding modulates antibody-mediated neutralization of West Nile virus.

PLoS Pathog 2011 Jun 30;7(6):e1002111. Epub 2011 Jun 30.

Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1002111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128118PMC
June 2011

Antibody-mediated neutralization of flaviviruses: a reductionist view.

Virology 2011 Mar 20;411(2):306-15. Epub 2011 Jan 20.

National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1016/j.virol.2010.12.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100196PMC
March 2011

Structure and function analysis of therapeutic monoclonal antibodies against dengue virus type 2.

J Virol 2010 Sep 30;84(18):9227-39. Epub 2010 Jun 30.

Department of Medicine,Washington University School of Medicine, 660 South Euclid Ave., Box 8051, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1128/JVI.01087-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2937608PMC
September 2010

Modeling antibody-enhanced dengue virus infection and disease in mice: protection or pathogenesis?

Cell Host Microbe 2010 Feb;7(2):85-6

Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.chom.2010.02.004DOI Listing
February 2010

Protonation of individual histidine residues is not required for the pH-dependent entry of west nile virus: evaluation of the "histidine switch" hypothesis.

J Virol 2009 Dec 23;83(23):12631-5. Epub 2009 Sep 23.

Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1128/JVI.01072-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2786769PMC
December 2009

Waste not, want not: a viral RNA degradation product modulates west nile virus pathogenesis.

Cell Host Microbe 2008 Dec;4(6):512-3

Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.chom.2008.11.004DOI Listing
December 2008

Temperature-dependent production of pseudoinfectious dengue reporter virus particles by complementation.

Virology 2008 Nov 17;381(1):67-74. Epub 2008 Sep 17.

Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1016/j.virol.2008.08.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428711PMC
November 2008

The structural immunology of antibody protection against West Nile virus.

Immunol Rev 2008 Oct;225:212-25

Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1111/j.1600-065X.2008.00676.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646609PMC
October 2008

Identification and biochemical characterization of small-molecule inhibitors of west nile virus serine protease by a high-throughput screen.

Antimicrob Agents Chemother 2008 Sep 7;52(9):3385-93. Epub 2008 Jul 7.

Department of Microbiology and Immunology, Georgetown University School of Medicine, Washington, DC 20057, USA.

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http://dx.doi.org/10.1128/AAC.01508-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533463PMC
September 2008

Structural insights into the mechanisms of antibody-mediated neutralization of flavivirus infection: implications for vaccine development.

Cell Host Microbe 2008 Sep;4(3):229-38

Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institutes of Health, 33 North Drive, Building 33, Room 1E19A.2, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.chom.2008.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678546PMC
September 2008

Maturation of West Nile virus modulates sensitivity to antibody-mediated neutralization.

PLoS Pathog 2008 May 9;4(5):e1000060. Epub 2008 May 9.

Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1000060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2330159PMC
May 2008

Molecular mechanisms of antibody-mediated neutralisation of flavivirus infection.

Expert Rev Mol Med 2008 May 12;10:e12. Epub 2008 May 12.

Viral Pathogenesis Section, Laboratory of Viral Diseases, NIAID, NIH, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1017/S1462399408000665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671962PMC
May 2008

A West Nile virus DNA vaccine induces neutralizing antibody in healthy adults during a phase 1 clinical trial.

J Infect Dis 2007 Dec;196(12):1732-40

Vaccine Research Center, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 40 Convent Drive, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1086/523650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714735PMC
December 2007

Induction of epitope-specific neutralizing antibodies against West Nile virus.

J Virol 2007 Nov 22;81(21):11828-39. Epub 2007 Aug 22.

Departments of Medicine, Molecular Microbiology, and Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1128/JVI.00643-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2168772PMC
November 2007

The stoichiometry of antibody-mediated neutralization and enhancement of West Nile virus infection.

Cell Host Microbe 2007 Apr;1(2):135-45

Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.chom.2007.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656919PMC
April 2007

The neutralizing antibody response against West Nile virus in naturally infected horses.

Virology 2007 Mar 20;359(2):336-48. Epub 2006 Oct 20.

Department of Microbiology, University of Pennsylvania, 225 Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.virol.2006.08.047DOI Listing
March 2007

The location of asparagine-linked glycans on West Nile virions controls their interactions with CD209 (dendritic cell-specific ICAM-3 grabbing nonintegrin).

J Biol Chem 2006 Dec 25;281(48):37183-94. Epub 2006 Sep 25.

Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1074/jbc.M605429200DOI Listing
December 2006

Antibody recognition and neutralization determinants on domains I and II of West Nile Virus envelope protein.

J Virol 2006 Dec 11;80(24):12149-59. Epub 2006 Oct 11.

Department of Medicine, Washington University School of Medicine, 660 South Euclid Ave., Box 8051, Saint Louis, MO 63110, USA.

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http://dx.doi.org/10.1128/JVI.01732-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1676294PMC
December 2006

A rapid and quantitative assay for measuring antibody-mediated neutralization of West Nile virus infection.

Virology 2006 Mar 2;346(1):53-65. Epub 2005 Dec 2.

Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.virol.2005.10.030DOI Listing
March 2006

West Nile virus discriminates between DC-SIGN and DC-SIGNR for cellular attachment and infection.

J Virol 2006 Feb;80(3):1290-301

Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1128/JVI.80.3.1290-1301.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1346927PMC
February 2006

Inhibition of dengue virus translation and RNA synthesis by a morpholino oligomer targeted to the top of the terminal 3' stem-loop structure.

Virology 2006 Jan 7;344(2):439-52. Epub 2005 Oct 7.

Division of Infectious Diseases, School of Public Health, University of California at Berkeley, 140 Warren Hall, Berkeley, CA 94720-7360, USA.

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http://dx.doi.org/10.1016/j.virol.2005.08.034DOI Listing
January 2006

N-linked glycosylation of west nile virus envelope proteins influences particle assembly and infectivity.

J Virol 2005 Nov;79(21):13262-74

Department of Microbiology, University of Pennsylvania, 225 Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104, USA.

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http://jvi.asm.org/cgi/doi/10.1128/JVI.79.21.13262-13274.200
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http://dx.doi.org/10.1128/JVI.79.21.13262-13274.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1262570PMC
November 2005

Castanospermine, a potent inhibitor of dengue virus infection in vitro and in vivo.

J Virol 2005 Jul;79(14):8698-706

Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, Box 8051, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1128/JVI.79.14.8698-8706.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1168722PMC
July 2005

Actively replicating West Nile virus is resistant to cytoplasmic delivery of siRNA.

Virol J 2005 Jun 28;2:53. Epub 2005 Jun 28.

Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, Box 8051, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1186/1743-422X-2-53DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1174879PMC
June 2005

Characterization of neutralizing antibodies to West Nile virus.

Virology 2005 May;336(1):70-82

Department of Microbiology, University of Pennsylvania, 225 Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.virol.2005.02.020DOI Listing
May 2005

An infectious West Nile virus that expresses a GFP reporter gene.

Virology 2005 Mar;334(1):28-40

Department of Microbiology, University of Pennsylvania, 225 Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.virol.2005.01.021DOI Listing
March 2005

Determinants within gp120 and gp41 contribute to CD4 independence of SIV Envs.

Virology 2004 Sep;327(1):16-25

Department of Microbiology, University of Pennsylvania, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1016/j.virol.2004.03.016DOI Listing
September 2004

Prospects of HIV-1 entry inhibitors as novel therapeutics.

Rev Med Virol 2004 Jul-Aug;14(4):255-70

Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1002/rmv.435DOI Listing
August 2004