Thea D Tlsty

Thea D Tlsty

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Thea D Tlsty

Thea D Tlsty

Publications by authors named "Thea D Tlsty"

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Stromal directives can control cancer.

Science 2019 07;365(6449):122-123

Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1126/science.aaw2368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6855670PMC
July 2019

Introducing cancer convergence.

Cancer Converg 2017 1;1(1). Epub 2017 Nov 1.

6Oregon State University, Corvallis, OR USA.

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http://dx.doi.org/10.1186/s41236-017-0003-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876691PMC
November 2017

Metastatic State of Cancer Cells May Be Indicated by Adhesion Strength.

Biophys J 2017 Feb;112(4):736-745

Department of Bioengineering, University of California, San Diego, La Jolla, California; Biomedical Sciences Program, University of California, San Diego, La Jolla, California; Sanford Consortium for Regenerative Medicine, La Jolla, California. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2016.12.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340156PMC
February 2017

SOX2, OCT3/4 and NANOG expression and cellular plasticity in rare human somatic cells requires CD73.

Cell Signal 2016 12 2;28(12):1923-1932. Epub 2016 Oct 2.

University of California San Francisco (UCSF) Helen Diller Comprehensive Cancer Center, United States; Department of Pathology, UCSF, 513 Parnassus Avenue, San Francisco, CA 94143-0511, United States. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2016.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107210PMC
December 2016

Risk prediction for local versus regional/metastatic tumors after initial ductal carcinoma in situ diagnosis treated by lumpectomy.

Breast Cancer Res Treat 2016 06 4;157(2):351-361. Epub 2016 May 4.

Departments of Medicine and Epidemiology and Biostatistics, UCSF, San Francisco, USA.

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http://dx.doi.org/10.1007/s10549-016-3814-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805143PMC
June 2016

Carcinoma-associated fibroblasts: orchestrating the composition of malignancy.

Genes Dev 2016 05;30(9):1002-19

Department of Pathology, University of California at San Francisco, San Francisco, California 94143, USA; Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California 94143, USA.

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http://dx.doi.org/10.1101/gad.279737.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863733PMC
May 2016

Towards aspirin-inspired self-immolating molecules which target the cyclooxygenases.

Org Biomol Chem 2015 Dec 24;13(45):11078-86. Epub 2015 Sep 24.

Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94107, USA.

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http://xlink.rsc.org/?DOI=C5OB01805F
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http://dx.doi.org/10.1039/c5ob01805fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644089PMC
December 2015

Novel insights from 3D models: the pivotal role of physical symmetry in epithelial organization.

Sci Rep 2015 Oct 16;5:15153. Epub 2015 Oct 16.

University of California Irvine, Department of Biomedical Engineering, Irvine, USA.

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http://dx.doi.org/10.1038/srep15153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608012PMC
October 2015

Integrative analysis of 111 reference human epigenomes.

Nature 2015 Feb;518(7539):317-30

1] Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, 32 Vassar St, Cambridge, Massachusetts 02139, USA. [2] The Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA.

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http://dx.doi.org/10.1038/nature14248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530010PMC
February 2015

Stress signaling from human mammary epithelial cells contributes to phenotypes of mammographic density.

Cancer Res 2014 Sep 29;74(18):5032-5044. Epub 2014 Aug 29.

Department of Pathology, University of California San Francisco, San Francisco, CA, 94143, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-3390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335659PMC
September 2014

Game theory in the death galaxy: interaction of cancer and stromal cells in tumour microenvironment.

Interface Focus 2014 Aug;4(4):20140028

Princeton Institute for the Science and Technology of Materials (PRISM) , Princeton, NJ 08544 , USA ; Department of Physics , Princeton University , Princeton, NJ 08544 , USA.

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http://dx.doi.org/10.1098/rsfs.2014.0028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4071511PMC
August 2014

Evolutionary game theory for physical and biological scientists. I. Training and validating population dynamics equations.

Interface Focus 2014 Aug;4(4):20140037

Department of Pathology , University of California San Francisco , San Francisco, CA 94143 , USA.

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http://dx.doi.org/10.1098/rsfs.2014.0037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4071513PMC
August 2014

Evolutionary game theory for physical and biological scientists. II. Population dynamics equations can be associated with interpretations.

Interface Focus 2014 Aug;4(4):20140038

Department of Pathology , University of California San Francisco , San Francisco, CA 94143 , USA.

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http://dx.doi.org/10.1098/rsfs.2014.0038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4071514PMC
August 2014

A physical sciences network characterization of non-tumorigenic and metastatic cells.

Authors:
David B Agus Jenolyn F Alexander Wadih Arap Shashanka Ashili Joseph E Aslan Robert H Austin Vadim Backman Kelly J Bethel Richard Bonneau Wei-Chiang Chen Chira Chen-Tanyolac Nathan C Choi Steven A Curley Matthew Dallas Dhwanil Damania Paul C W Davies Paolo Decuzzi Laura Dickinson Luis Estevez-Salmeron Veronica Estrella Mauro Ferrari Claudia Fischbach Jasmine Foo Stephanie I Fraley Christian Frantz Alexander Fuhrmann Philippe Gascard Robert A Gatenby Yue Geng Sharon Gerecht Robert J Gillies Biana Godin William M Grady Alex Greenfield Courtney Hemphill Barbara L Hempstead Abigail Hielscher W Daniel Hillis Eric C Holland Arig Ibrahim-Hashim Tyler Jacks Roger H Johnson Ahyoung Joo Jonathan E Katz Laimonas Kelbauskas Carl Kesselman Michael R King Konstantinos Konstantopoulos Casey M Kraning-Rush Peter Kuhn Kevin Kung Brian Kwee Johnathon N Lakins Guillaume Lambert David Liao Jonathan D Licht Jan T Liphardt Liyu Liu Mark C Lloyd Anna Lyubimova Parag Mallick John Marko Owen J T McCarty Deirdre R Meldrum Franziska Michor Shannon M Mumenthaler Vivek Nandakumar Thomas V O'Halloran Steve Oh Renata Pasqualini Matthew J Paszek Kevin G Philips Christopher S Poultney Kuldeepsinh Rana Cynthia A Reinhart-King Robert Ros Gregg L Semenza Patti Senechal Michael L Shuler Srimeenakshi Srinivasan Jack R Staunton Yolanda Stypula Hariharan Subramanian Thea D Tlsty Garth W Tormoen Yiider Tseng Alexander van Oudenaarden Scott S Verbridge Jenny C Wan Valerie M Weaver Jonathan Widom Christine Will Denis Wirtz Jonathan Wojtkowiak Pei-Hsun Wu

Sci Rep 2013 ;3:1449

Center for Applied Molecular Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.

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http://dx.doi.org/10.1038/srep01449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636513PMC
October 2013

Cell motility and drug gradients in the emergence of resistance to chemotherapy.

Proc Natl Acad Sci U S A 2013 Oct 17;110(40):16103-8. Epub 2013 Sep 17.

Princeton Institute for the Science and Technology of Materials, Department of Electrical Engineering, Princeton University, Princeton, NJ 08544.

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http://dx.doi.org/10.1073/pnas.1314385110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791735PMC
October 2013

Rare somatic cells from human breast tissue exhibit extensive lineage plasticity.

Proc Natl Acad Sci U S A 2013 Mar 4;110(12):4598-603. Epub 2013 Mar 4.

Helen Diller Comprehensive Cancer Center, University of California, San Francisco, CA 94143-0511, USA.

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http://dx.doi.org/10.1073/pnas.1218682110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607035PMC
March 2013

Conceptualizing a tool to optimize therapy based on dynamic heterogeneity.

Phys Biol 2012 Dec 29;9(6):065005. Epub 2012 Nov 29.

Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1088/1478-3975/9/6/065005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3618714PMC
December 2012

Generalized principles of stochasticity can be used to control dynamic heterogeneity.

Phys Biol 2012 Dec 29;9(6):065006. Epub 2012 Nov 29.

Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1088/1478-3975/9/6/065006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3618713PMC
December 2012

Hello out there...is anybody listening?

Cancer Discov 2012 Dec;2(12):1084-6

Department of Pathology and 2Comprehensive Cancer Center, University of California San Francisco, San Francisco, California 94143, USA.

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http://dx.doi.org/10.1158/2159-8290.CD-12-0434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326255PMC
December 2012

p16(INK4a) expression and breast cancer risk in women with atypical hyperplasia.

Cancer Prev Res (Phila) 2011 Dec 15;4(12):1953-60. Epub 2011 Sep 15.

Division of Biochemistry/Molecular Biology, Mayo Clinic in Jacksonville, Jacksonville, Florida 32224, USA.

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http://dx.doi.org/10.1158/1940-6207.CAPR-11-0282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3232312PMC
December 2011

Tissue states provide novel insights into attributes that drive metastasis.

Authors:
Thea D Tlsty

Cancer Cell 2011 Sep;20(3):285-6

Helen Diller Comprehensive Cancer Center, University of California, San Francisco, CA 94143-0511, USA.

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http://dx.doi.org/10.1016/j.ccr.2011.08.018DOI Listing
September 2011

Tumor microenvironment and progression.

J Surg Oncol 2011 May;103(6):468-74

Department of Pathology, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

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http://doi.wiley.com/10.1002/jso.21709
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http://dx.doi.org/10.1002/jso.21709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277953PMC
May 2011

A twist of cell fate.

Authors:
Thea D Tlsty

Cell Stem Cell 2011 Feb;8(2):126-7

University of California-San Francisco, CA 94143-0506, USA.

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http://dx.doi.org/10.1016/j.stem.2011.01.004DOI Listing
February 2011

Human mammary cancer progression model recapitulates methylation events associated with breast premalignancy.

Breast Cancer Res 2009 8;11(6):R87. Epub 2009 Dec 8.

Department of Pathology and Comprehensive Cancer Center, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, California, 94143-0511, USA.

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http://dx.doi.org/10.1186/bcr2457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815551PMC
July 2010

Premalignant breast neoplasia: a paradigm of interlesional and intralesional molecular heterogeneity and its biological and clinical ramifications.

Cancer Prev Res (Phila) 2010 May 27;3(5):579-87. Epub 2010 Apr 27.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/1940-6207.CAPR-10-0073DOI Listing
May 2010

Unprecedented opportunities and promise for cancer prevention research.

Cancer Prev Res (Phila) 2010 Apr 30;3(4):394-402. Epub 2010 Mar 30.

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http://dx.doi.org/10.1158/1940-6207.CAPR-10-0051DOI Listing
April 2010

Primary cilia regulate branching morphogenesis during mammary gland development.

Curr Biol 2010 Apr 8;20(8):731-7. Epub 2010 Apr 8.

Department of Cell Biology and Anatomy, University of Arizona and Arizona Cancer Center, Tucson, AZ 85724, USA.

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http://dx.doi.org/10.1016/j.cub.2010.02.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2916967PMC
April 2010

Reflections on miR-ing effects in metastasis.

Cancer Cell 2009 Jul;16(1):3-4

Department of Pathology, University of California at San Francisco, San Francisco, CA 94143, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S15356108090018
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http://dx.doi.org/10.1016/j.ccr.2009.06.013DOI Listing
July 2009

Sustained induction of epithelial to mesenchymal transition activates DNA methylation of genes silenced in basal-like breast cancers.

Proc Natl Acad Sci U S A 2008 Sep 19;105(39):14867-72. Epub 2008 Sep 19.

Department of Pathology and Comprehensive Cancer Center, University of California, San Francisco, CA 94143-0511, USA.

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http://dx.doi.org/10.1073/pnas.0807146105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2567459PMC
September 2008

Tumor stroma and regulation of cancer development.

Annu Rev Pathol 2006 ;1:119-50

Department of Pathology and Comprehensive Cancer Center, University of California, San Francisco, California 94115, USA.

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http://www.annualreviews.org/doi/10.1146/annurev.pathol.1.11
Publisher Site
http://dx.doi.org/10.1146/annurev.pathol.1.110304.100224DOI Listing
December 2007

Luminal cells GATA have it.

Authors:
Thea D Tlsty

Nat Cell Biol 2007 Feb;9(2):135-6

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http://dx.doi.org/10.1038/ncb0207-135DOI Listing
February 2007

p16INK4a modulates p53 in primary human mammary epithelial cells.

Cancer Res 2006 Nov;66(21):10325-31

Department of Pathology and UCSF Comprehensive Cancer Center, University of California San Francisco, California 94143, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-1594DOI Listing
November 2006

Simulating properties of in vitro epithelial cell morphogenesis.

PLoS Comput Biol 2006 Oct 17;2(10):e129. Epub 2006 Aug 17.

University of California San Francisco/University of California Berkeley Joint Graduate Group in Bioengineering, University of California Berkeley, Berkeley, California, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.0020129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1592363PMC
October 2006

Tumor suppressor p16INK4A regulates polycomb-mediated DNA hypermethylation in human mammary epithelial cells.

J Biol Chem 2006 Aug 9;281(34):24790-802. Epub 2006 Jun 9.

Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California 94143-0511, USA.

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http://dx.doi.org/10.1074/jbc.M604175200DOI Listing
August 2006

p16(INK4a) prevents centrosome dysfunction and genomic instability in primary cells.

PLoS Biol 2006 Mar 14;4(3):e51. Epub 2006 Feb 14.

Department of Pathology, UCSF Comprehensive Cancer Center, University of California San Francisco, California, USA.

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http://dx.doi.org/10.1371/journal.pbio.0040051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1361797PMC
March 2006

p38 regulates cyclooxygenase-2 in human mammary epithelial cells and is activated in premalignant tissue.

Cancer Res 2005 Mar;65(5):1792-9

Department of Pathology, University of California San Francisco Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California 94143-0511, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-3507DOI Listing
March 2005

Genetic and epigenetic changes in mammary epithelial cells may mimic early events in carcinogenesis.

J Mammary Gland Biol Neoplasia 2004 Jul;9(3):263-74

Department of Pathology and UCSF Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California 94143-0511, USA.

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http://dx.doi.org/10.1023/B:JOMG.0000048773.95897.5fDOI Listing
July 2004

Histologically normal human mammary epithelia with silenced p16(INK4a) overexpress COX-2, promoting a premalignant program.

Cancer Cell 2004 Mar;5(3):263-73

Department of Pathology and Comprehensive Cancer Center, University of California at San Francisco, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1016/s1535-6108(04)00023-6DOI Listing
March 2004

Cyclooxygenase-2 expression is related to nuclear grade in ductal carcinoma in situ and is increased in its normal adjacent epithelium.

Cancer Res 2003 May;63(10):2347-50

University of California at San Francisco Comprehensive Cancer Center, University of California, San Francisco, California 94115-1710, USA.

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May 2003

Methylation of p16(INK4a) promoters occurs in vivo in histologically normal human mammary epithelia.

Cancer Res 2003 Apr;63(7):1596-601

Department of Pathology and University of California at San Francisco Comprehensive Cancer Center 94143-0511, USA.

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April 2003

Functions of p53 suppress critical consequences of damage and repair in the initiation of cancer.

Authors:
Thea D Tlsty

Cancer Cell 2002 Jul;2(1):2-4

Department of Pathology, UCSF Comprehensive Cancer Center, University of California at San Francisco, 94143, USA.

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http://dx.doi.org/10.1016/s1535-6108(02)00088-0DOI Listing
July 2002