Thavendran Govender

Thavendran Govender

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Thavendran Govender

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Time-dependent regional brain distribution of methadone and naltrexone in the treatment of opioid addiction.

Addict Biol 2019 May 14;24(3):438-446. Epub 2018 Feb 14.

Catalysis and Peptide Research Unit, University of KwaZulu-Natal, South Africa.

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http://dx.doi.org/10.1111/adb.12609DOI Listing
May 2019

Brain penetration of ketamine: Intranasal delivery VS parenteral routes of administraion.

J Psychiatr Res 2019 May 20;112:7-11. Epub 2019 Feb 20.

Catalysis and Peptide Research Unit, University of KwaZulu-Natal, Westville Campus, Durban, South Africa. Electronic address:

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http://dx.doi.org/10.1016/j.jpsychires.2019.02.003DOI Listing
May 2019

The Driving Force for the Acylation of β-Lactam Antibiotics by L,D-Transpeptidase 2: Quantum Mechanics/Molecular Mechanics (QM/MM) Study.

Chemphyschem 2019 05 10;20(9):1126-1134. Epub 2019 Apr 10.

Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, 4041, South Africa.

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http://dx.doi.org/10.1002/cphc.201900173DOI Listing
May 2019

Rilpivirine as a potential candidate for the treatment of HIV-associated neurocognitive disorders (HAND).

J Mol Histol 2019 Apr 22. Epub 2019 Apr 22.

Catalysis and Peptide Research Unit, University of KwaZulu-Natal, Westville Campus, E-block, 6th floor, Room E1-06-016, Durban, South Africa.

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http://link.springer.com/10.1007/s10735-019-09826-y
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http://dx.doi.org/10.1007/s10735-019-09826-yDOI Listing
April 2019

Inhibition mechanism of L,D-transpeptidase 5 in presence of the β-lactams using ONIOM method.

J Mol Graph Model 2019 Mar 28;87:204-210. Epub 2018 Nov 28.

Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, 4001, South Africa. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10933263183073
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http://dx.doi.org/10.1016/j.jmgm.2018.11.009DOI Listing
March 2019

Optimized Procedure for Recovering HIV-1 Protease (C-SA) from Inclusion Bodies.

Protein J 2019 02;38(1):30-36

Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, 4001, South Africa.

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http://dx.doi.org/10.1007/s10930-018-9805-7DOI Listing
February 2019

Structure and function of L,D- and D,D-transpeptidase family enzymes from Mycobacterium tuberculosis.

Curr Med Chem 2018 12 3. Epub 2018 Dec 3.

Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban 4001. South Africa.

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http://dx.doi.org/10.2174/0929867326666181203150231DOI Listing
December 2018

The catalytic role of water in the binding site of l,d-transpeptidase 2 within acylation mechanism: A QM/MM (ONIOM) modelling.

Tuberculosis (Edinb) 2018 12 19;113:222-230. Epub 2018 Oct 19.

Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, 4041, South Africa. Electronic address:

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http://dx.doi.org/10.1016/j.tube.2018.10.005DOI Listing
December 2018

Exploring the flap dynamics of the South African HIV subtype C protease in presence of FDA-approved inhibitors: MD study.

Chem Biol Drug Des 2018 Nov 24;92(5):1899-1913. Epub 2018 Sep 24.

Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.

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http://doi.wiley.com/10.1111/cbdd.13364
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http://dx.doi.org/10.1111/cbdd.13364DOI Listing
November 2018

From recognition to reaction mechanism: an overview on the interactions between HIV-1 protease and its natural targets.

Curr Med Chem 2018 Nov 13. Epub 2018 Nov 13.

Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban 4041. South Africa.

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http://www.eurekaselect.com/167313/article
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http://dx.doi.org/10.2174/0929867325666181113122900DOI Listing
November 2018

The downfall of TBA-354 - a possible explanation for its neurotoxicity via mass spectrometric imaging.

Xenobiotica 2018 Sep 13;48(9):938-944. Epub 2017 Oct 13.

a Catalysis and Peptide Research Unit, University of KwaZulu-Natal , Durban , South Africa.

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http://dx.doi.org/10.1080/00498254.2017.1375168DOI Listing
September 2018

Molecular insight on the non-covalent interactions between carbapenems and L,D-transpeptidase 2 from Mycobacterium tuberculosis: ONIOM study.

J Comput Aided Mol Des 2018 Jun 29;32(6):687-701. Epub 2018 May 29.

Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, 4001, South Africa.

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http://dx.doi.org/10.1007/s10822-018-0121-2DOI Listing
June 2018

Enhanced brain penetration of pretomanid by intranasal administration of an oil-in-water nanoemulsion.

Nanomedicine (Lond) 2018 05 23;13(9):997-1008. Epub 2018 May 23.

Catalysis & Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban 4000, South Africa.

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http://dx.doi.org/10.2217/nnm-2017-0365DOI Listing
May 2018

Solid-Phase Synthesis of Pyrrole Derivatives through a Multicomponent Reaction Involving Lys-Containing Peptides.

ACS Comb Sci 2018 04 22;20(4):187-191. Epub 2018 Feb 22.

Catalysis and Peptide Research Unit , School of Health Sciences, University of KwaZulu-Natal , University Road , Westville, Durban 4001 , South Africa.

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http://dx.doi.org/10.1021/acscombsci.8b00006DOI Listing
April 2018

An insight to the molecular interactions of the FDA approved HIV PR drugs against L38L↑N↑L PR mutant.

J Comput Aided Mol Des 2018 03 3;32(3):459-471. Epub 2018 Feb 3.

Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, 4001, South Africa.

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http://link.springer.com/10.1007/s10822-018-0099-9
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http://dx.doi.org/10.1007/s10822-018-0099-9DOI Listing
March 2018

Microwave-Assisted Synthesis of Antimicrobial Peptides.

Methods Mol Biol 2017 ;1548:51-59

Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Westville Campus, E-Block, 6th Floor, Room E1-06-016, Durban, 4001, South Africa.

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http://link.springer.com/10.1007/978-1-4939-6737-7_4
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http://dx.doi.org/10.1007/978-1-4939-6737-7_4DOI Listing
February 2018

Ga-NOTA-Functionalized Ubiquicidin: Cytotoxicity, Biodistribution, Radiation Dosimetry, and First-in-Human PET/CT Imaging of Infections.

J Nucl Med 2018 02 19;59(2):334-339. Epub 2017 Oct 19.

Department of Science and Technology, Preclinical Drug Development Platform, North West University, Potchefstroom, South Africa.

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http://dx.doi.org/10.2967/jnumed.117.200048DOI Listing
February 2018

Clofazimine protects against Mycobacterium tuberculosis dissemination in the central nervous system following aerosol challenge in a murine model.

Int J Antimicrob Agents 2018 Jan 24;51(1):77-81. Epub 2017 Aug 24.

Catalysis and Peptide Research Unit, School of Pharmacy and Pharmacology, University of KwaZulu-Natal, Westville Campus, Durban, South Africa. Electronic address:

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http://dx.doi.org/10.1016/j.ijantimicag.2017.08.020DOI Listing
January 2018

Chemical Platforms for Peptide Vaccine Constructs.

Adv Protein Chem Struct Biol 2015 27;99:99-130. Epub 2015 Apr 27.

Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa; School of Chemistry, Yachay Tech, Yachay City of Knowledge, Urcuqui, Ecuador. Electronic address:

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http://dx.doi.org/10.1016/bs.apcsb.2015.03.005DOI Listing
December 2017

Lansoprazole-sulfide, pharmacokinetics of this promising anti-tuberculous agent.

Biomed Chromatogr 2017 Dec 13;31(12). Epub 2017 Jul 13.

Catalysis and Peptide Research Unit, University of KwaZulu-Natal, Westville Campus, Durban, South Africa.

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http://dx.doi.org/10.1002/bmc.4035DOI Listing
December 2017

Metabolic Imaging of Infection.

J Nucl Med 2017 11 17;58(11):1727-1732. Epub 2017 Aug 17.

Department of Nuclear Medicine, University of Pretoria, Pretoria, South Africa

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http://dx.doi.org/10.2967/jnumed.117.191635DOI Listing
November 2017

Synthesis, in vitro evaluation, and Ga-radiolabeling of CDP1 toward PET/CT imaging of bacterial infection.

Chem Biol Drug Des 2017 Oct 17;90(4):572-579. Epub 2017 Apr 17.

Catalysis and Peptide Research Unit, School of Health Sciences and School of Chemistry and Physics, University of KwaZulu-Natal, Durban, South Africa.

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http://dx.doi.org/10.1111/cbdd.12980DOI Listing
October 2017

Post heroin dose tissue distribution of 6-monoacetylmorphine (6-MAM) with MALDI imaging.

J Mol Histol 2017 Aug 26;48(4):285-292. Epub 2017 May 26.

Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, E-block, 6th floor, Room E1-06-016, Westville Campus, Durban, 4000, South Africa.

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http://dx.doi.org/10.1007/s10735-017-9726-3DOI Listing
August 2017

The role of nanotechnology in the treatment of viral infections.

Ther Adv Infect Dis 2017 Jul 5;4(4):105-131. Epub 2017 Jul 5.

Department of Virology, National Health Laboratory Service, University of KwaZulu-Natal, Durban, South Africa.

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http://dx.doi.org/10.1177/2049936117713593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507392PMC
July 2017

Synthetic approaches to radiochemical probes for imaging of bacterial infections.

Eur J Med Chem 2017 Jun 29;133:287-308. Epub 2017 Mar 29.

Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban 4001, South Africa. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2017.03.060DOI Listing
June 2017

Differential flap dynamics in l,d-transpeptidase2 from mycobacterium tuberculosis revealed by molecular dynamics.

Mol Biosyst 2017 Jun 8;13(6):1223-1234. Epub 2017 May 8.

Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, 4001, South Africa.

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http://dx.doi.org/10.1039/c7mb00110jDOI Listing
June 2017

Fast and efficient detection of tuberculosis antigens using liposome encapsulated secretory proteins of Mycobacterium tuberculosis.

J Microbiol Immunol Infect 2017 Apr 8;50(2):189-198. Epub 2015 Jul 8.

Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.

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http://dx.doi.org/10.1016/j.jmii.2015.05.014DOI Listing
April 2017

Sulfonimidamides in Medicinal and Agricultural Chemistry.

Angew Chem Int Ed Engl 2017 04 23;56(15):4100-4109. Epub 2017 Feb 23.

Catalysis and Peptide Research Unit, University of KwaZulu Natal, Durban, 4001, South Africa.

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http://dx.doi.org/10.1002/anie.201610456DOI Listing
April 2017

Potential inhibition of HIV-1 encapsidation by oligoribonucleotide-dendrimer nanoparticle complexes.

Int J Nanomedicine 2017 4;12:317-325. Epub 2017 Jan 4.

Catalysis and Peptide Research Unit, University of KwaZulu-Natal, Durban, South Africa.

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http://dx.doi.org/10.2147/IJN.S114446DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5221794PMC
March 2017

A Synthesis of "Dual Warhead" β-Aryl Ethenesulfonyl Fluorides and One-Pot Reaction to β-Sultams.

Org Lett 2017 02 11;19(3):480-483. Epub 2017 Jan 11.

Catalysis and Peptide Research Unit, University of KwaZulu-Natal , Durban, South Africa.

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http://dx.doi.org/10.1021/acs.orglett.6b03634DOI Listing
February 2017

Lysine Scanning of Arg-Teixobactin: Deciphering the Role of Hydrophobic and Hydrophilic Residues.

ACS Omega 2016 Dec 19;1(6):1262-1265. Epub 2016 Dec 19.

Catalysis and Peptide Research Unit, School of Health Sciences and School of Chemistry and Physics, University of KwaZulu-Natal, University Road, Durban 4001, South Africa.

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http://dx.doi.org/10.1021/acsomega.6b00354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044708PMC
December 2016

Rapid and widespread distribution of doxycycline in rat brain: a mass spectrometric imaging study.

Xenobiotica 2016 31;46(5):385-92. Epub 2015 Aug 31.

a Catalysis and Peptide Research Unit, University of KwaZulu-Natal , Westville Campus , Durban , South Africa and.

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http://dx.doi.org/10.3109/00498254.2015.1081307DOI Listing
November 2016

Artificial Intelligence vs. Statistical Modeling and Optimization of Continuous Bead Milling Process for Bacterial Cell Lysis.

Front Microbiol 2016 22;7:1852. Epub 2016 Nov 22.

Research and Scientific Studies Unit, College of Nursing and Allied Health Sciences, Jazan UniversityJazan, Saudi Arabia; RFCL LimitedNew Delhi, India.

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http://dx.doi.org/10.3389/fmicb.2016.01852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118707PMC
November 2016

Targeting the cell wall of Mycobacterium tuberculosis: a molecular modeling investigation of the interaction of imipenem and meropenem with L,D-transpeptidase 2.

J Biomol Struct Dyn 2016 24;34(2):304-17. Epub 2015 Jul 24.

a Laboratório de Planejamento e Desenvolvimento de Fármacos, Instituto de Ciências Exatas e Naturais , Universidade Federal do Pará , CP 11101, Belém , PA 66075-110 , Brazil.

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http://dx.doi.org/10.1080/07391102.2015.1029000DOI Listing
October 2016

Tissue distribution of pretomanid in rat brain via mass spectrometry imaging.

Xenobiotica 2016 24;46(3):247-52. Epub 2015 Jul 24.

a School of Pharmacy and Pharmacology, University of KwaZulu-Natal , Durban , South Africa and.

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http://dx.doi.org/10.3109/00498254.2015.1067935DOI Listing
October 2016

Mechanistic investigation of the uncatalyzed esterification reaction of acetic acid and acid halides with methanol: a DFT study.

J Mol Model 2016 Oct 7;22(10):235. Epub 2016 Sep 7.

Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, 4041, South Africa.

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http://dx.doi.org/10.1007/s00894-016-3084-zDOI Listing
October 2016

MALDI MSI and LC-MS/MS: Towards preclinical determination of the neurotoxic potential of fluoroquinolones.

Drug Test Anal 2016 Aug 18;8(8):832-8. Epub 2015 Sep 18.

Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban, 4000, South Africa.

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http://dx.doi.org/10.1002/dta.1862DOI Listing
August 2016

Neuroprotective potential of Linezolid: a quantitative and distribution study via mass spectrometry.

J Mol Histol 2016 Aug 21;47(4):429-35. Epub 2016 Jun 21.

Catalysis and Peptide Research Unit, University of KwaZulu-Natal, E-Block, 6th Floor, Room E1-06-016, Westville Campus, Durban, South Africa.

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http://dx.doi.org/10.1007/s10735-016-9685-0DOI Listing
August 2016

Enantioselective Organocatalyzed Transformations of β-Ketoesters.

Chem Rev 2016 08 27;116(16):9375-437. Epub 2016 Jul 27.

Catalysis and Peptide Research Unit, University of KwaZulu Natal , Durban, 4001, South Africa.

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http://dx.doi.org/10.1021/acs.chemrev.6b00156DOI Listing
August 2016

Short AntiMicrobial Peptides (SAMPs) as a class of extraordinary promising therapeutic agents.

J Pept Sci 2016 Jul;22(7):438-51

Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, 4001, South Africa.

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http://dx.doi.org/10.1002/psc.2894DOI Listing
July 2016

Purification and characterization of naturally occurring HIV-1 (South African subtype C) protease mutants from inclusion bodies.

Protein Expr Purif 2016 06 23;122:90-6. Epub 2016 Feb 23.

Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban 4001, South Africa. Electronic address:

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http://dx.doi.org/10.1016/j.pep.2016.02.013DOI Listing
June 2016

Efficient Purification of rhG-CSF and its PEGylated Forms and Evaluation for In Vitro Activities.

Protein Pept Lett 2015 ;22(10):877-84

Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.

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May 2016

Binding Free Energy Calculations of Nine FDA-approved Protease Inhibitors Against HIV-1 Subtype C I36T↑T Containing 100 Amino Acids Per Monomer.

Chem Biol Drug Des 2016 Apr 29;87(4):487-98. Epub 2016 Jan 29.

Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, 4001, South Africa.

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http://dx.doi.org/10.1111/cbdd.12690DOI Listing
April 2016

Small molecule distribution in rat lung: a comparison of various cryoprotectants as inflation media and their applicability to MSI.

J Mol Histol 2016 Apr 13;47(2):213-9. Epub 2016 Jan 13.

Catalysis and Peptide Research Unit, University of KwaZulu-Natal, Westville Campus, E-Block, 6th Floor, Room E1-06-016, Durban, South Africa.

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http://dx.doi.org/10.1007/s10735-016-9658-3DOI Listing
April 2016

On-Water Synthesis of Biaryl Sulfonyl Fluorides.

J Org Chem 2016 Mar 29;81(6):2618-23. Epub 2016 Feb 29.

Science for Life Laboratory, Drug Discovery & Development Platform & Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet , SE-171 21 Stockholm, Sweden.

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http://dx.doi.org/10.1021/acs.joc.5b02770DOI Listing
March 2016

2-Methyltetrahydrofuran and cyclopentyl methyl ether for green solid-phase peptide synthesis.

Amino Acids 2016 Feb 24;48(2):419-26. Epub 2015 Sep 24.

Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, 4001, South Africa.

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http://dx.doi.org/10.1007/s00726-015-2095-xDOI Listing
February 2016

Highly chemoselective ligation of thiol- and amino-peptides on a bromomaleimide core.

Chem Commun (Camb) 2016 Feb;52(11):2334-7

Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban 4001, South Africa.

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http://dx.doi.org/10.1039/c5cc09457gDOI Listing
February 2016

Synthesis and Biological Evaluation of a Teixobactin Analogue.

Org Lett 2015 Dec 10;17(24):6182-5. Epub 2015 Dec 10.

Institute for Research in Biomedicine-Barcelona ,08028 Barcelona, Spain.

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http://dx.doi.org/10.1021/acs.orglett.5b03176DOI Listing
December 2015

Evidence for the presence of clofazimine and its distribution in the healthy mouse brain.

J Mol Histol 2015 Oct 25;46(4-5):439-42. Epub 2015 Jul 25.

Catalysis and Peptide Research Unit, School of Pharmacy and Pharmacology, University of KwaZulu-Natal, Westville Campus, Durban, South Africa.

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http://dx.doi.org/10.1007/s10735-015-9634-3DOI Listing
October 2015

The effect of N-methylation of amino acids (Ac-X-OMe) on solubility and conformation: a DFT study.

Org Biomol Chem 2015 Oct;13(39):9993-10006

Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban 4001, South Africa.

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http://www.rsc.org/suppdata/c5/ob/c5ob01565k/c5ob01565k3.pdf
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http://xlink.rsc.org/?DOI=C5OB01565K
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http://dx.doi.org/10.1039/c5ob01565kDOI Listing
October 2015

Simulating the inhibition reaction of Mycobacterium tuberculosis L,D-transpeptidase 2 by carbapenems.

Chem Commun (Camb) 2015 Aug;51(63):12560-2

Laboratório de Planejamento e Desenvolvimento de Fármacos, Instituto de Ciências Exatas e Naturais, Universidade Federal do Pará, Belém, Pará, Brazil.

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http://dx.doi.org/10.1039/c5cc03202dDOI Listing
August 2015

A sensitive WST-8-based bioassay for PEGylated granulocyte colony stimulating factor using the NFS-60 cell line.

Pharm Biol 2015 Jun 25;53(6):849-54. Epub 2014 Nov 25.

Gennova Biopharmaceuticals Ltd., Rajeev Gandhi International Biotech Park , Phase-II, Pune , India .

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http://dx.doi.org/10.3109/13880209.2014.943248DOI Listing
June 2015

Visualization of Time-Dependent Distribution of Rifampicin in Rat Brain Using MALDI MSI and Quantitative LCMS/MS.

Assay Drug Dev Technol 2015 Jun 12;13(5):277-84. Epub 2015 Jun 12.

1 Catalysis and Peptide Research Unit, University of KwaZulu-Natal , Westville Campus, Durban, South Africa .

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http://dx.doi.org/10.1089/adt.2015.634DOI Listing
June 2015

NOTA: a potent metallo-β-lactamase inhibitor.

J Antimicrob Chemother 2015 May 6;70(5):1594-6. Epub 2015 Jan 6.

Antimicrobial Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa

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http://dx.doi.org/10.1093/jac/dku538DOI Listing
May 2015

Determination of the antitubercular drug PA-824 in rat plasma, lung and brain tissues by liquid chromatography tandem mass spectrometry: application to a pharmacokinetic study.

J Chromatogr B Analyt Technol Biomed Life Sci 2015 Apr 9;988:187-94. Epub 2015 Mar 9.

Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban 4000, South Africa. Electronic address:

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http://dx.doi.org/10.1016/j.jchromb.2015.02.041DOI Listing
April 2015

An efficient solid-phase strategy for total synthesis of naturally occurring amphiphilic marine siderophores: amphibactin-T and moanachelin ala-B.

Org Biomol Chem 2015 Apr;13(16):4760-8

Catalysis and Peptide Research Unit, School of Health Sciences, University of Kwazulu-Natal, Durban 4001, South Africa.

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http://dx.doi.org/10.1039/c5ob00100eDOI Listing
April 2015

Structural and functional features of enzymes of Mycobacterium tuberculosis peptidoglycan biosynthesis as targets for drug development.

Tuberculosis (Edinb) 2015 Mar 29;95(2):95-111. Epub 2015 Jan 29.

Laboratório de Planejamento de Fármacos, Instituto de Ciências Exatas e Naturais, Universidade Federal do Pará, CEP 66075-110 Belém, PA, Brazil; Instituto de Ciências Biológicas, Universidade Federal do Pará, CEP 66075-110 Belém, PA, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.tube.2015.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659487PMC
March 2015

Peptide synthesis beyond DMF: THF and ACN as excellent and friendlier alternatives.

Org Biomol Chem 2015 Feb;13(8):2393-8

Catalysis and Peptide Research Unit, School of Health Sciences, University of Kwazulu-Natal, Durban 4001, South Africa.

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http://xlink.rsc.org/?DOI=C4OB02046D
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http://dx.doi.org/10.1039/c4ob02046dDOI Listing
February 2015

6-(Bromomaleimido)hexanoic acid as a connector for the construction of multiple branched peptide platforms.

Org Lett 2015 Feb 12;17(3):464-7. Epub 2015 Jan 12.

Catalysis and Peptide Research Unit, School of Health Sciences and ‡School of Chemistry and Physics, University of KwaZulu-Natal , Durban 4001, South Africa.

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http://dx.doi.org/10.1021/ol503463uDOI Listing
February 2015

Pentacycloundecane lactam vs lactone norstatine type protease HIV inhibitors: binding energy calculations and DFT study.

J Biomed Sci 2015 Feb 18;22:15. Epub 2015 Feb 18.

Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, 4041, South Africa.

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http://dx.doi.org/10.1186/s12929-015-0115-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387594PMC
February 2015

Peptide synthesis, characterization and ⁶⁸Ga-radiolabeling of NOTA-conjugated ubiquicidin fragments for prospective infection imaging with PET/CT.

Nucl Med Biol 2014 May-Jun;41(5):390-400. Epub 2014 Feb 13.

Department of Science and Technology, Preclinical Drug Development Platform, North West University, Potchefstroom, South Africa. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09698051140004
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http://dx.doi.org/10.1016/j.nucmedbio.2014.02.001DOI Listing
December 2014

Oxyma-B, an excellent racemization suppressor for peptide synthesis.

Org Biomol Chem 2014 Nov;12(42):8379-85

Catalysis and Peptide Research Unit, School of Health Sciences, University of Kwazulu-Natal, Durban 4001, South Africa.

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http://dx.doi.org/10.1039/c4ob01612bDOI Listing
November 2014

Immobilized coupling reagents: synthesis of amides/peptides.

ACS Comb Sci 2014 Nov 24;16(11):579-601. Epub 2014 Oct 24.

Catalysis and Peptide Research Unit, School of Health Sciences, University of Kwazulu-Natal , Durban 4001, South Africa.

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http://dx.doi.org/10.1021/co500126yDOI Listing
November 2014

TOMBU and COMBU as Novel Uronium-type peptide coupling reagents derived from Oxyma-B.

Molecules 2014 Nov 18;19(11):18953-65. Epub 2014 Nov 18.

Catalysis and Peptide Research Unit, School of Health Sciences, University of Kwazulu-Natal, Durban 4001, South Africa.

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http://dx.doi.org/10.3390/molecules191118953DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271478PMC
November 2014

Microreactors for peptide synthesis: looking through the eyes of twenty first century !!!

Amino Acids 2014 Sep 25;46(9):2091-104. Epub 2014 Jun 25.

Catalysis and Peptide Research Unit, University of KwaZulu-Natal, Durban, 4001, South Africa.

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http://dx.doi.org/10.1007/s00726-014-1776-1DOI Listing
September 2014

Solid-phase peptide synthesis (SPPS), C-terminal vs. side-chain anchoring: a reality or a myth.

Amino Acids 2014 Aug 26;46(8):1827-38. Epub 2014 Apr 26.

Catalysis and Peptide Research Unit, School of Health Sciences, University of Kwazulu-Natal, Durban, 4001, South Africa.

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http://dx.doi.org/10.1007/s00726-014-1746-7DOI Listing
August 2014

Proline N-oxides: modulators of the 3D conformation of linear peptides through "NO-turns".

Org Biomol Chem 2014 Jul;12(25):4479-90

Catalysis and Peptide Research Unit, School of Health Sciences, University of Kwazulu-Natal, Durban 4001, South Africa.

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http://dx.doi.org/10.1039/c4ob00433gDOI Listing
July 2014

Preclinical evaluation of 68Ga-labeled 1,4,7-triazacyclononane-1,4,7-triacetic acid-ubiquicidin as a radioligand for PET infection imaging.

J Nucl Med 2014 Feb 16;55(2):308-14. Epub 2014 Jan 16.

Department of Nuclear Medicine, University of Pretoria and Steve Biko Academic Hospital, Pretoria, South Africa.

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http://jnm.snmjournals.org/cgi/doi/10.2967/jnumed.113.128397
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February 2014

Integrated approach to structure-based enzymatic drug design: molecular modeling, spectroscopy, and experimental bioactivity.

Chem Rev 2014 Jan 11;114(1):493-537. Epub 2013 Sep 11.

Catalysis and Peptide Research Unit and ‡School of Health Sciences, University of KwaZulu Natal , Durban 4001, South Africa.

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http://dx.doi.org/10.1021/cr300314qDOI Listing
January 2014

Organocatalyzed stereospecific C-C bond formation of β-lactams.

Org Biomol Chem 2013 Dec 11;11(48):8294-7. Epub 2013 Nov 11.

Catalysis and Peptide Research Unit, University of KwaZulu Natal, Durban, South Africa.

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http://dx.doi.org/10.1039/c3ob41858hDOI Listing
December 2013

{2-[(1,3-Benzo-thia-zol-2-yl)meth-oxy]-5-fluoro-phen-yl}(4-chloro-phen-yl)methanone.

Acta Crystallogr Sect E Struct Rep Online 2013 8;69(Pt 7):o1007-8. Epub 2013 Jun 8.

School of Pharmacy and Pharmacology, University of KwaZulu-Natal, Durban 4000, South Africa.

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http://dx.doi.org/10.1107/S1600536813014621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772451PMC
September 2013

Anticancer activity of ruthenium(II) arene complexes bearing 1,2,3,4-tetrahydroisoquinoline amino alcohol ligands.

Eur J Med Chem 2013 Aug 12;66:407-14. Epub 2013 Jun 12.

Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban 4000, KwaZulu-Natal, South Africa.

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http://dx.doi.org/10.1016/j.ejmech.2013.05.048DOI Listing
August 2013

Linear and cyclic glycopeptide as HIV protease inhibitors.

Eur J Med Chem 2013 Feb 29;60:144-54. Epub 2012 Nov 29.

Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, South Africa.

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http://dx.doi.org/10.1016/j.ejmech.2012.11.018DOI Listing
February 2013

[2-(1,3-Benzothia-zol-2-ylmeth-oxy)-5-bromo-phen-yl](4-chloro-phen-yl)methanone.

Acta Crystallogr Sect E Struct Rep Online 2013 Jan 12;69(Pt 1):o70. Epub 2012 Dec 12.

Center for Nano Science and Technology@Polimi, Istituto Italiano di Tecnologia, Via Pascoli 70/3-20133 Milan, Italy.

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http://dx.doi.org/10.1107/S1600536812049756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588233PMC
January 2013

Methyl 2-(2,3,5-trimethyl-1,1-dioxo-2H-1λ(6),2,6-thia-diazin-4-yl)benzoate.

Acta Crystallogr Sect E Struct Rep Online 2012 Dec 17;68(Pt 12):o3360. Epub 2012 Nov 17.

Chemistry Department, JJT University, Rajasthan, India.

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http://dx.doi.org/10.1107/S1600536812046375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588958PMC
December 2012

(2-(Benzo[d]thia-zol-2yl-meth-oxy)-5-chloro-phen-yl)(phen-yl)methanone.

Acta Crystallogr Sect E Struct Rep Online 2012 Nov 13;68(Pt 11):o3125. Epub 2012 Oct 13.

School of Pharmacy and Pharmacology, University of KwaZulu-Natal, Durban 4000, South Africa.

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http://dx.doi.org/10.1107/S1600536812041888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515230PMC
November 2012

2-(3,5-Dimethyl-1,1-dioxo-2H-1λ(6),2,6-thia-diazin-4-yl)benzoic acid.

Acta Crystallogr Sect E Struct Rep Online 2012 Oct 5;68(Pt 10):o2859. Epub 2012 Sep 5.

Chemistry Department, JJT University, Rajasthan, India.

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http://dx.doi.org/10.1107/S1600536812037026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470217PMC
October 2012

Novel polycyclic 'cage'-1,2-diamines as potential anti-tuberculosis agents.

Eur J Med Chem 2012 Aug 4;54:1-9. Epub 2012 Apr 4.

School of Chemistry, University of KwaZulu-Natal, Durban, South Africa.

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http://dx.doi.org/10.1016/j.ejmech.2012.03.041DOI Listing
August 2012

Enantioselective synthesis of chiral sulfones by Ir-catalyzed asymmetric hydrogenation: a facile approach to the preparation of chiral allylic and homoallylic compounds.

J Am Chem Soc 2012 Aug 7;134(33):13592-5. Epub 2012 Aug 7.

Department of Chemistry-BMC, Uppsala University, Box 576, S-75123 Uppsala, Sweden.

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http://dx.doi.org/10.1021/ja306731uDOI Listing
August 2012

Molecular modeling of T. rangeli, T. brucei gambiense, and T. evansi sialidases in complex with the DANA inhibitor.

Chem Biol Drug Des 2012 Jul 13;80(1):114-20. Epub 2012 Apr 13.

Laboratório de Planejamento e Desenvolvimento de Fármacos, Instituto de Ciências Exatas e Naturais, Universidade Federal do Pará, CP 11101, 66075-110 Belém, PA, Brazil.

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http://dx.doi.org/10.1111/j.1747-0285.2012.01380.xDOI Listing
July 2012

Synthesis and molecular modelling studies of novel carbapeptide analogs for inhibition of HIV-1 protease.

Eur J Med Chem 2012 Jul 4;53:13-21. Epub 2012 Apr 4.

School of Pharmacy and Pharmacology, University of KwaZulu-Natal, Durban, KwaZulu-Natal 4000, South Africa.

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http://dx.doi.org/10.1016/j.ejmech.2012.03.027DOI Listing
July 2012

Chiral hetero- and carbocyclic compounds from the asymmetric hydrogenation of cyclic alkenes.

Chemistry 2012 May 24;18(21):6507-13. Epub 2012 Apr 24.

Department of Biochemistry and Organic Chemistry, Uppsala University, Box 576, S-75123, Uppsala, Sweden.

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http://dx.doi.org/10.1002/chem.201104073DOI Listing
May 2012

Polycyclic cage structures as lipophilic scaffolds for neuroactive drugs.

ChemMedChem 2012 Mar 3;7(3):375-84. Epub 2012 Feb 3.

School of Pharmacy, University of the Western Cape, Private Bag X17, Bellville 7535, South Africa.

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http://doi.wiley.com/10.1002/cmdc.201100559
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http://dx.doi.org/10.1002/cmdc.201100559DOI Listing
March 2012

Interaction of beta-amyloid interactions with peptide functionalized gold nanoparticles.

J Nanosci Nanotechnol 2012 Mar;12(3):2179-84

School of Chemistry, University of KwaZulu Natal, Durban 4001, South Africa.

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March 2012

(S)-Methyl 2-benzamido-3-(3,4-dimeth-oxy-phen-yl)propano-ate.

Acta Crystallogr Sect E Struct Rep Online 2012 Jan 21;68(Pt 1):o177. Epub 2011 Dec 21.

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http://dx.doi.org/10.1107/S1600536811052767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3254516PMC
January 2012