Publications by authors named "Thang Nguyen Tat"

3 Publications

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Fabrication of -Type Co₃O₄ Nanofiber Sensors for Ultra-Low H₂S Gas Detection at Low Temperature.

J Nanosci Nanotechnol 2021 Apr;21(4):2626-2632

International Training Institute for Materials Science (ITIMS), Hanoi University of Science and Technology (HUST), 100000, Hanoi, Vietnam.

In the current work, we report the on-chip fabrication of a low-temperature H₂S sensor based on -type Co₃O₄ nanofibers (NFs) using the electrospinning method. The FESEM images show the typical spider-net like morphologies of synthesized Co₃O₄ NFs with an average diameter of 90 nm formed on the comb-like electrodes. The EDX data indicate the presence of Co and O elements in the NFs. The XRD analysis results confirm the formation of single-phase cubic spinel nanocrystalline structures () for the synthesized Co₃O₄ NFs. The Raman results are in agreement with the XRD data through the presence of five typical vibration modes of the nanocrystalline Co₃O₄. The gas sensing properties of the fabricated Co₃O₄ NF sensors are tested to 1 ppm H₂S within a temperature range of 150 °C to 450 °C. The results indicate a highest sensor response to 1 ppm H₂S with the gas response of aproximately 2.1 times and the gas response/recovery times of 75 s/258 s at a low temperature of 250 °C. The fabricated sensor also demonstrates good selectivity and a low detection limit of 18 ppb. The overall results suggest a simple and effective fabrication process for the -type Co₃O₄ NF sensor for practical applications in detecting H₂S gas at low temperature.
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http://dx.doi.org/10.1166/jnn.2021.19111DOI Listing
April 2021

Superantigens of Colonization in Atopic Dermatitis and Treatment Efficacy of Oral Cefuroxim in Vietnamese Patients.

Open Access Maced J Med Sci 2019 Jan 20;7(2):243-246. Epub 2019 Jan 20.

University of Rome G. Marconi, Rome, Italy.

Background: Atopic dermatitis (AD) is a common, chronic, relapsing, genetically determined inflammatory skin disorder. Staphylococcus aureus (S. aureus) plays an important role in the pathogenesis of AD. Atopic skin is susceptible to infection with .

Aim: This study was aimed to compare the skin colonisation status and its secretion of superantigens in adult AD and healthy subjects and to evaluate the efficacy of two treatment regimens (oral cefuroxime plus topical betamethasone dipropionate 0.05% versus topical betamethasone dipropionate 0.05%) in AD patients.

Methods: A group of 128 AD and 40 healthy subjects were recruited in this study and treatment efficacy was assessed by the SCORAD score.

Results: was found in skin lesions in 83.8% of AD patients while only 37.5% of healthy subjects possessed this kind of bacteria in the external nares (p < 0.001). Superantigen production was more common in strains isolated from AD than the control group (58.6% versus 6.6%, p = 0.0006) and staphylococcal enterotoxin B was predominant (88.89%). 68 AD patients who had positive cultures with were included in a clinical therapeutic trial. The isolated bacteria were all sensitive to cefuroxime. Patients were randomised to receive either oral cefuroxime 500 mg b.i.d. Plus topical betamethasone dipropionate 0.05% twice daily for 2 weeks (so-called group 1, 36 patients) or only topical betamethasone dipropionate 0.05% twice daily for 2 weeks (so-called group 2, 32 patients). The mean SCORAD scores of group 1 at baseline and after 1 and 2 weeks of treatment were 44.61, 26.69 and 16.61, respectively. The corresponding values for group 2 were 43.03, 32.53 and 23.41, respectively.

Conclusion: The reduction in SCORAD scores was significantly higher in group 1 than group 2 in comparison to the baseline value of each study group (p = 0.003 after 1 week and p < 0.001 at the end of treatment).
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http://dx.doi.org/10.3889/oamjms.2019.061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364715PMC
January 2019

Efficacy of Adding Oral Simvastatin to Topical Therapy for Treatment of Psoriasis: The Vietnamese Experience.

Open Access Maced J Med Sci 2019 Jan 27;7(2):237-242. Epub 2019 Jan 27.

University of Rome G. Marconi, Rome, Italy.

Background: Psoriasis, the prevalence of which ranges from 2% to 3% of the general population, has been recently recognised as not only a chronic inflammatory skin disorder but also an immunometabolic systemic disease. Dyslipidemia is one of the most important comorbidities of psoriasis. Statins, frequently used as anti-hyperlipidemic agents, may be beneficial in the treatment of several autoimmune diseases, including psoriasis, due to their anti-inflammatory and immunomodulatory characteristics. Hence, we hypothesised that using this medication was not only beneficial for reducing hyperlipidemia but also improving psoriatic conditions.

Aim: We conducted a study to determine the prevalence of dyslipidemia in psoriatic patients as well as whether the addition of statins (simvastatin prescribed forms) to standard topical antipsoriatic treatment can improve skin lesions in psoriatic patients.

Methods: A group of 128 psoriatic patients and 128 healthy controls who were matched with the patients regarding ethnicity, age, and sex were enrolled, and their lipid concentrations were determined. Furthermore, sixty patients were randomly selected from the former group and divided into two treatment subgroups to evaluate the effect of statins on the severity of psoriasis using the PASI score.

Results: We found that the rate of dyslipidemia in the patient group was significantly higher than in the healthy group (53.9% versus 21.9%, p < 0.001), particularly the triglyceride concentration (1.86 ± 1.17 versus 1.43 ± 0.79 mg/dL, p < 0.001). Also, the PASI score reduction in the simvastatin-treated subgroup was significantly different from that in the placebo-treated one after eight weeks of therapy (8.63 ± 4.78 versus 5.34 ± 3.59, p < 0.01).

Conclusion: This study showed that simvastatin might play a role in controlling hyperlipidemia and in turn decrease the PASI score in psoriatic patients.
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http://dx.doi.org/10.3889/oamjms.2019.060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364708PMC
January 2019