Publications by authors named "Tewis Bouwmeester"

55Publications

BET bromodomain inhibitors regulate keratinocyte plasticity.

Authors:
Gabi Schutzius Christian Kolter Sebastian Bergling Federico Tortelli Florian Fuchs Steffen Renner Vito Guagnano Simona Cotesta Heinrich Rueeger Michael Faller Laure Bouchez Adrian Salathe Florian Nigsch Shola M Richards Malvina Louis Viktoria Gruber Alexandra Aebi Jonathan Turner Frederic Grandjean Jun Li Chris Dimitri Jason R Thomas Markus Schirle Jutta Blank Peter Drueckes Andrea Vaupel Ralph Tiedt Paul W Manley Julia Klopp Rene Hemmig Florence Zink Nelly Leroy Walter Carbone Guglielmo Roma Caroline Gubser Keller Natalie Dales Armin Beyerbach Alfred Zimmerlin Debora Bonenfant Remi Terranova Amy Berwick Sukhdeep Sahambi Aimee Reynolds Lori L Jennings Heinz Ruffner Peter Tarsa Tewis Bouwmeester Vickie Driver Mathias Frederiksen Felix Lohmann Susan Kirkland

Nat Chem Biol 2021 Jan 18. Epub 2021 Jan 18.

Novartis Institutes for BioMedical Research, Basel, Switzerland.

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January 2021

A virtual reality system to analyze neural activity and behavior in adult zebrafish.

Authors:
Kuo-Hua Huang Peter Rupprecht Thomas Frank Koichi Kawakami Tewis Bouwmeester Rainer W Friedrich

Nat Methods 2020 03 2;17(3):343-351. Epub 2020 Mar 2.

Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.

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March 2020

AXIN2 Pericentral Hepatocytes Have Limited Contributions to Liver Homeostasis and Regeneration.

Authors:
Tianliang Sun Monika Pikiolek Vanessa Orsini Sebastian Bergling Sjoerd Holwerda Lapo Morelli Philipp S Hoppe Lara Planas-Paz Yi Yang Heinz Ruffner Tewis Bouwmeester Felix Lohmann Luigi M Terracciano Guglielmo Roma Feng Cong Jan S Tchorz

Cell Stem Cell 2020 01 19;26(1):97-107.e6. Epub 2019 Dec 19.

Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland. Electronic address:

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January 2020

IRF2 is a master regulator of human keratinocyte stem cell fate.

Authors:
Nicolas Mercado Gabi Schutzius Christian Kolter David Estoppey Sebastian Bergling Guglielmo Roma Caroline Gubser Keller Florian Nigsch Adrian Salathe Remi Terranova John Reece-Hoyes John Alford Carsten Russ Judith Knehr Dominic Hoepfner Alexandra Aebi Heinz Ruffner Tanner C Beck Sajjeev Jagannathan Calla M Olson Hadley E Sheppard Selma Z Elsarrag Tewis Bouwmeester Mathias Frederiksen Felix Lohmann Charles Y Lin Susan Kirkland

Nat Commun 2019 10 14;10(1):4676. Epub 2019 Oct 14.

Chemical Biology & Therapeutics, Novartis Institutes for Biomedical Research, Novartis Pharma AG, Forum 1 Novartis Campus, CH-4056, Basel, Switzerland.

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October 2019

Liver biopsy derived induced pluripotent stem cells provide unlimited supply for the generation of hepatocyte-like cells.

Authors:
Diego Calabrese Guglielmo Roma Sebastian Bergling Walter Carbone Valentina Mele Sandro Nuciforo Isabel Fofana Benedetta Campana Dagmara Szkolnicka David C Hay Jan Tchorz Tewis Bouwmeester Stefan Wieland Markus H Heim

PLoS One 2019 29;14(8):e0221762. Epub 2019 Aug 29.

Department of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland.

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March 2020

Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation.

Authors:
Julius Rabl Richard D Bunker Andreas D Schenk Simone Cavadini Mark E Gill Wassim Abdulrahman Amparo Andrés-Pons Martijn S Luijsterburg Adel F M Ibrahim Emma Branigan Jacob D Aguirre Aimee H Marceau Claire Guérillon Tewis Bouwmeester Ulrich Hassiepen Antoine H F M Peters Martin Renatus Laurent Gelman Seth M Rubin Niels Mailand Haico van Attikum Ronald T Hay Nicolas H Thomä

Mol Cell 2019 08 25;75(3):483-497.e9. Epub 2019 Jun 25.

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland; University of Basel, Petersplatz 10, 4003 Basel, Switzerland. Electronic address:

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August 2019

YAP, but Not RSPO-LGR4/5, Signaling in Biliary Epithelial Cells Promotes a Ductular Reaction in Response to Liver Injury.

Authors:
Lara Planas-Paz Tianliang Sun Monika Pikiolek Nadire R Cochran Sebastian Bergling Vanessa Orsini Zinger Yang Frederic Sigoillot Jasna Jetzer Maryam Syed Marilisa Neri Sven Schuierer Lapo Morelli Philipp S Hoppe Wibke Schwarzer Carlos M Cobos John L Alford Le Zhang Rachel Cuttat Annick Waldt Nicole Carballido-Perrig Florian Nigsch Bernd Kinzel Thomas B Nicholson Yi Yang Xiaohong Mao Luigi M Terracciano Carsten Russ John S Reece-Hoyes Caroline Gubser Keller Andreas W Sailer Tewis Bouwmeester Linda E Greenbaum Jesse J Lugus Feng Cong Gregory McAllister Gregory R Hoffman Guglielmo Roma Jan S Tchorz

Cell Stem Cell 2019 07 9;25(1):39-53.e10. Epub 2019 May 9.

Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland. Electronic address:

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July 2019

Transcriptomic analysis reveals reduced transcriptional activity in the malaria parasite during progression into dormancy.

Authors:
Nicole L Bertschi Annemarie Voorberg-van der Wel Anne-Marie Zeeman Sven Schuierer Florian Nigsch Walter Carbone Judith Knehr Devendra K Gupta Sam O Hofman Nicole van der Werff Ivonne Nieuwenhuis Els Klooster Bart W Faber Erika L Flannery Sebastian A Mikolajczak Vorada Chuenchob Binesh Shrestha Martin Beibel Tewis Bouwmeester Niwat Kangwanrangsan Jetsumon Sattabongkot Thierry T Diagana Clemens Hm Kocken Guglielmo Roma

Elife 2018 12 27;7. Epub 2018 Dec 27.

Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Europe.

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December 2018

Author Correction: Transneuronal propagation of mutant huntingtin contributes to non-cell autonomous pathology in neurons.

Authors:
Eline Pecho-Vrieseling Claus Rieker Sascha Fuchs Dorothee Bleckmann Maria Soledad Esposito Paolo Botta Chris Goldstein Mario Bernhard Ivan Galimberti Matthias Müller Andreas Lüthi Silvia Arber Tewis Bouwmeester Herman van der Putten Francesco Paolo Di Giorgio

Nat Neurosci 2018 Sep;21(9):1291

Novartis Institutes for Biomedical Research, Basel, Switzerland.

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September 2018

A comparative transcriptomic analysis of replicating and dormant liver stages of the relapsing malaria parasite .

Authors:
Annemarie Voorberg-van der Wel Guglielmo Roma Devendra Kumar Gupta Sven Schuierer Florian Nigsch Walter Carbone Anne-Marie Zeeman Boon Heng Lee Sam O Hofman Bart W Faber Judith Knehr Erica Pasini Bernd Kinzel Pablo Bifani Ghislain M C Bonamy Tewis Bouwmeester Clemens H M Kocken Thierry Tidiane Diagana

Elife 2017 12 7;6. Epub 2017 Dec 7.

Novartis Institute for Tropical Diseases, Singapore, Singapore.

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December 2017

A natural ligand for the orphan receptor GPR15 modulates lymphocyte recruitment to epithelia.

Authors:
Thomas Suply Sébastien Hannedouche Nathalie Carte Jianping Li Bianka Grosshans Michael Schaefer Layla Raad Valérie Beck Solange Vidal Agnès Hiou-Feige Noémie Beluch Samuel Barbieri Johann Wirsching Nadine Lageyre Frank Hillger Corinne Debon Janet Dawson Philip Smith Vincent Lannoy Michel Detheux Francis Bitsch Rocco Falchetto Tewis Bouwmeester Jeffrey Porter Birgit Baumgarten Keith Mansfield José M Carballido Klaus Seuwen Frédéric Bassilana

Sci Signal 2017 Sep 12;10(496). Epub 2017 Sep 12.

Novartis Institutes for BioMedical Research, CH-4056 Basel, Switzerland.

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September 2017

Multidimensional pooled shRNA screens in human THP-1 cells identify candidate modulators of macrophage polarization.

Authors:
Ewa Surdziel Ieuan Clay Florian Nigsch Anke Thiemeyer Cyril Allard Gregory Hoffman John S Reece-Hoyes Tanushree Phadke Romain Gambert Caroline Gubser Keller Marie-Gabrielle Ludwig Birgit Baumgarten Mathias Frederiksen Dirk Schübeler Klaus Seuwen Tewis Bouwmeester Barna D Fodor

PLoS One 2017 24;12(8):e0183679. Epub 2017 Aug 24.

Novartis Institutes for Biomedical Research, Basel, Switzerland.

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October 2017

The Natural Product Cavinafungin Selectively Interferes with Zika and Dengue Virus Replication by Inhibition of the Host Signal Peptidase.

Authors:
David Estoppey Chia Min Lee Marco Janoschke Boon Heng Lee Kah Fei Wan Hongping Dong Philippe Mathys Ireos Filipuzzi Tim Schuhmann Ralph Riedl Thomas Aust Olaf Galuba Gregory McAllister Carsten Russ Martin Spiess Tewis Bouwmeester Ghislain M C Bonamy Dominic Hoepfner

Cell Rep 2017 04;19(3):451-460

Novartis Institutes for BioMedical Research, Novartis Pharma AG, Forum 1 Novartis Campus, 4056 Basel, Switzerland; Biozentrum, University of Basel, Klingelbergstrasse 50/70, 4056 Basel, Switzerland. Electronic address:

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April 2017

Screening of Intestinal Crypt Organoids: A Simple Readout for Complex Biology.

Authors:
Svenja Ley Olaf Galuba Adrian Salathe Nicolas Melin Alexandra Aebi Monika Pikiolek Judith Knehr Walter Carbone Martin Beibel Florian Nigsch Guglielmo Roma Giovanni d'Ario Susan Kirkland Laure C Bouchez Caroline Gubser Keller Tewis Bouwmeester Christian N Parker Heinz Ruffner

SLAS Discov 2017 06 6;22(5):571-582. Epub 2017 Jan 6.

1 Novartis Institutes for BioMedical Research (NIBR), Developmental and Molecular Pathways (DMP), Basel, Switzerland.

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June 2017

Identification of a novel NAMPT inhibitor by CRISPR/Cas9 chemogenomic profiling in mammalian cells.

Authors:
David Estoppey Jeffrey W Hewett Chantale T Guy Edmund Harrington Jason R Thomas Markus Schirle Rachel Cuttat Annick Waldt Bertran Gerrits Zinger Yang Sven Schuierer Xuewen Pan Kevin Xie Walter Carbone Judith Knehr Alicia Lindeman Carsten Russ Elizabeth Frias Gregory R Hoffman Malini Varadarajan Nadire Ramadan John S Reece-Hoyes Qiong Wang Xin Chen Gregory McAllister Guglielmo Roma Tewis Bouwmeester Dominic Hoepfner

Sci Rep 2017 02 16;7:42728. Epub 2017 Feb 16.

Novartis Institutes for BioMedical Research, Novartis Pharma AG, Forum 1 Novartis Campus, CH-4056 Basel, Switzerland.

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February 2017

CGG Repeat-Induced FMR1 Silencing Depends on the Expansion Size in Human iPSCs and Neurons Carrying Unmethylated Full Mutations.

Authors:
Urszula Brykczynska Eline Pecho-Vrieseling Anke Thiemeyer Jessica Klein Isabelle Fruh Thierry Doll Carole Manneville Sascha Fuchs Mariavittoria Iazeolla Martin Beibel Guglielmo Roma Ulrike Naumann Nicholas Kelley Edward J Oakeley Matthias Mueller Baltazar Gomez-Mancilla Marc Bühler Elisabetta Tabolacci Pietro Chiurazzi Giovanni Neri Tewis Bouwmeester Francesco Paolo Di Giorgio Barna D Fodor

Stem Cell Reports 2016 12 10;7(6):1059-1071. Epub 2016 Nov 10.

Novartis Institutes for Biomedical Research, 4056 Basel, Switzerland. Electronic address:

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December 2016

Corrigendum: The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size.

Authors:
Lara Planas-Paz Vanessa Orsini Luke Boulter Diego Calabrese Monika Pikiolek Florian Nigsch Yang Xie Guglielmo Roma Adriana Donovan Patricia Marti Nicolau Beckmann Michael T Dill Walter Carbone Sebastian Bergling Andrea Isken Matthias Mueller Bernd Kinzel Yi Yang Xiaohong Mao Thomas B Nicholson Raffaella Zamponi Paola Capodieci Reginald Valdez Daniel Rivera Andreas Loew Chinweike Ukomadu Luigi M Terracciano Tewis Bouwmeester Feng Cong Markus H Heim Stuart J Forbes Heinz Ruffner Jan S Tchorz

Nat Cell Biol 2016 10;18(11):1260

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October 2016

Identification of oncogenic driver mutations by genome-wide CRISPR-Cas9 dropout screening.

Authors:
Michael K Kiessling Sven Schuierer Silke Stertz Martin Beibel Sebastian Bergling Judith Knehr Walter Carbone Cheryl de Vallière Joelle Tchinda Tewis Bouwmeester Klaus Seuwen Gerhard Rogler Guglielmo Roma

BMC Genomics 2016 09 9;17(1):723. Epub 2016 Sep 9.

Novartis Institutes for Biomedical Research, Novartis Pharma AG, Basel, Switzerland.

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September 2016

MiR-210 promotes sensory hair cell formation in the organ of corti.

Authors:
Sabrina Riccardi Sebastian Bergling Frederic Sigoillot Martin Beibel Annick Werner Juliet Leighton-Davies Judith Knehr Tewis Bouwmeester Christian N Parker Guglielmo Roma Bernd Kinzel

BMC Genomics 2016 Apr 27;17:309. Epub 2016 Apr 27.

Developmental and Molecular Pathways, Novartis Institute for Biomedical Research, Basel, Switzerland.

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April 2016

The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size.

Authors:
Lara Planas-Paz Vanessa Orsini Luke Boulter Diego Calabrese Monika Pikiolek Florian Nigsch Yang Xie Guglielmo Roma Adriana Donovan Patricia Marti Nicolau Beckmann Michael T Dill Walter Carbone Sebastian Bergling Andrea Isken Matthias Mueller Bernd Kinzel Yi Yang Xiaohong Mao Thomas B Nicholson Raffaella Zamponi Paola Capodieci Reginald Valdez Daniel Rivera Andreas Loew Chinweike Ukomadu Luigi M Terracciano Tewis Bouwmeester Feng Cong Markus H Heim Stuart J Forbes Heinz Ruffner Jan S Tchorz

Nat Cell Biol 2016 05 18;18(5):467-79. Epub 2016 Apr 18.

Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland.

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May 2016