Terry Van Dyke

Terry Van Dyke

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Terry Van Dyke

Terry Van Dyke

Publications by authors named "Terry Van Dyke"

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Inactivation of TRP53, PTEN, RB1 and/or CDH1 in the ovarian surface epithelium induces ovarian cancer transformation and metastasis.

Biol Reprod 2020 Jan 13. Epub 2020 Jan 13.

Department of Physiology, Southern Illinois University School of Medicine, Carbondale, IL.

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http://dx.doi.org/10.1093/biolre/ioaa008DOI Listing
January 2020

Aurora-A promotes the establishment of spindle assembly checkpoint by priming the Haspin-Aurora-B feedback loop in late G2 phase.

Cell Discov 2017 10;3:16049. Epub 2017 Jan 10.

Key Laboratory of Innate Immunity and Chronic Disease of CAS, Innovation Center for Cell Biology, School of Life Sciences, Hefei National Laboratory for Physical Sciences at Microscale, University of Science and Technology of China , Hefei, China.

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http://dx.doi.org/10.1038/celldisc.2016.49DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223110PMC
January 2017

Concepts in Cancer Modeling: A Brief History.

Cancer Res 2016 10 30;76(20):5921-5925. Epub 2016 Sep 30.

Laboratory of Cancer Biology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-1293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5117812PMC
October 2016

Preclinical mouse cancer models: a maze of opportunities and challenges.

Cell 2015 Sep;163(1):39-53

Center for Advanced Preclinical Research, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.08.068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583714PMC
September 2015

The genetics of splicing in neuroblastoma.

Cancer Discov 2015 Apr 30;5(4):380-95. Epub 2015 Jan 30.

Department of Neurology, University of California, San Francisco, San Francisco, California. Department of Neurosurgery, University of California, San Francisco, San Francisco, California. Department of Pediatrics, University of California, San Francisco, San Francisco, California.

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http://dx.doi.org/10.1158/2159-8290.CD-14-0892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390477PMC
April 2015

A preclinical orthotopic model for glioblastoma recapitulates key features of human tumors and demonstrates sensitivity to a combination of MEK and PI3K pathway inhibitors.

Dis Model Mech 2015 Jan 27;8(1):45-56. Epub 2014 Nov 27.

Center for Advanced Preclinical Research, Leidos Biomedical Research, Inc, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1242/dmm.018168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283649PMC
January 2015

Expression quantitative trait loci and receptor pharmacology implicate Arg1 and the GABA-A receptor as therapeutic targets in neuroblastoma.

Cell Rep 2014 Nov 23;9(3):1034-46. Epub 2014 Oct 23.

Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Pediatrics, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.09.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251494PMC
November 2014

Akt-dependent activation of mTORC1 complex involves phosphorylation of mTOR (mammalian target of rapamycin) by IκB kinase α (IKKα).

J Biol Chem 2014 Sep 2;289(36):25227-40. Epub 2014 Jul 2.

From the Lineberger Comprehensive Cancer Center University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599,

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http://dx.doi.org/10.1074/jbc.M114.554881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155685PMC
September 2014

Discovery of a mutant-selective covalent inhibitor of EGFR that overcomes T790M-mediated resistance in NSCLC.

Cancer Discov 2013 Dec 24;3(12):1404-15. Epub 2013 Sep 24.

1Clovis Oncology Inc., San Francisco, California; 2Celgene Avilomics Research, Bedford, Massachusetts; 3Division of Hematology-Oncology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee; 4Mouse Cancer Genetics Program; and 5Center for Advanced Preclinical Research, Science Applications International Corporation-Frederick, Inc., National Cancer Institute, Frederick, Maryland.

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http://dx.doi.org/10.1158/2159-8290.CD-13-0314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048995PMC
December 2013

Requirements for Aurora-A in tissue regeneration and tumor development in adult mammals.

Cancer Res 2013 Nov;73(22):6804-15

Authors' Affiliations: Cell Division and Cancer Group; Histopathology Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain; and Department of Genetics and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-0586DOI Listing
November 2013

Cooperativity between MAPK and PI3K signaling activation is required for glioblastoma pathogenesis.

Neuro Oncol 2013 Oct 27;15(10):1317-29. Epub 2013 Jun 27.

Corresponding Author: C. Ryan Miller, MD, PhD, University of North Carolina School of Medicine, 6109B Neurosciences Research Building, Campus Box 7250, Chapel Hill, NC 27599-7250.

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http://dx.doi.org/10.1093/neuonc/not084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779038PMC
October 2013

Conditional Aurora A deficiency differentially affects early mouse embryo patterning.

Dev Biol 2012 Nov 25;371(1):77-85. Epub 2012 Aug 25.

Department of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA.

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http://dx.doi.org/10.1016/j.ydbio.2012.08.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467101PMC
November 2012

Perturbation of Rb, p53, and Brca1 or Brca2 cooperate in inducing metastatic serous epithelial ovarian cancer.

Cancer Res 2012 Aug 22;72(16):4141-53. Epub 2012 May 22.

Center for Advanced Preclinical Research, Advanced Biomedical Computing Center, SAIC at Frederick National Laboratory for Cancer Research, Mouse Cancer Genetics Program, NCI-Frederick, Frederick, Maryland 21702, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-3834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3421072PMC
August 2012

β-catenin in metastatic melanoma--the smoking gun reloaded.

Pigment Cell Melanoma Res 2012 Mar 12;25(2):125-6. Epub 2012 Jan 12.

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http://dx.doi.org/10.1111/j.1755-148X.2011.00964.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533435PMC
March 2012

Finding the tumor copycat: approximating a human cancer.

Authors:
Terry Van Dyke

Nat Med 2010 Sep;16(9):976-7

Mouse Cancer Genetics Program, Center for Advanced Preclinical Research, National Cancer Institute, Frederick, Maryland, USA.

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http://dx.doi.org/10.1038/nm0910-976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533444PMC
September 2010

VHL and PTEN loss coordinate to promote mouse liver vascular lesions.

Angiogenesis 2010 Mar 11;13(1):59-69. Epub 2010 Mar 11.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, 27599-7295, USA.

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http://link.springer.com/10.1007/s10456-010-9164-2
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http://dx.doi.org/10.1007/s10456-010-9164-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872996PMC
March 2010

Advances in Prostate Cancer Research--AACR Special Conference In Cancer Research.

IDrugs 2009 Mar;12(3):159-62

University of North Carolina, Lineberger Comprehensive Cancer Center, Department of Biochemistry and Biophysics, Van Dyke Laboratory, Chapel Hill, NC 27599, USA.

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March 2009

Aurora-A kinase is essential for bipolar spindle formation and early development.

Mol Cell Biol 2009 Feb 15;29(4):1059-71. Epub 2008 Dec 15.

Department of Genetics and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina 275991, USA.

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http://dx.doi.org/10.1128/MCB.01062-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2643803PMC
February 2009

It takes a (dysfunctional) village to raise a tumor.

Cell 2008 Oct;135(3):408-10

Mouse Cancer Genetics Program, National Cancer Institute at Frederick, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1016/j.cell.2008.10.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693258PMC
October 2008

Engineering and Selection of Shuffled AAV Genomes: A New Strategy for Producing Targeted Biological Nanoparticles.

Mol Ther 2008 Jul 8;16(7):1252-1260. Epub 2016 Dec 8.

Gene Therapy Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. Electronic address:

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http://dx.doi.org/10.1038/mt.2008.100DOI Listing
July 2008

Optimization of self-complementary AAV vectors for liver-directed expression results in sustained correction of hemophilia B at low vector dose.

Mol Ther 2008 Feb 4;16(2):280-9. Epub 2007 Dec 4.

Gene Therapy Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7352, USA.

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http://dx.doi.org/10.1038/sj.mt.6300355DOI Listing
February 2008

Stopping ras in its tracks.

Cell 2007 Jun;129(5):855-7

Department of Pharmacology, University of North Carolina at Chapel Hill, Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S009286740700670
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http://dx.doi.org/10.1016/j.cell.2007.05.031DOI Listing
June 2007

Tumor-specific cooperation of retinoblastoma protein family and Snf5 inactivation.

Cancer Res 2007 Apr;67(7):3002-9

Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-4207DOI Listing
April 2007

p53 and tumor suppression.

Authors:
Terry Van Dyke

N Engl J Med 2007 Jan;356(1):79-81

Department of Genetics and the Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, USA.

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http://www.nejm.org/doi/abs/10.1056/NEJMcibr066301
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http://dx.doi.org/10.1056/NEJMcibr066301DOI Listing
January 2007

In vivo inactivation of pRb, p107 and p130 in murine neuroprogenitor cells leads to major CNS developmental defects and high seizure rates.

Mol Cell Neurosci 2006 Nov 18;33(3):260-73. Epub 2006 Sep 18.

Curriculum in Neurobiology, UNC Neuroscience Center and Neurodevelopmental Disorders Research Center, Chapel Hill, NC 27599-7295, USA.

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http://dx.doi.org/10.1016/j.mcn.2006.07.012DOI Listing
November 2006

Mouse Models of Human Cancers Consortium Workshop on Nervous System Tumors.

Cancer Res 2006 Jan;66(1):10-3

Department of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-05-3180DOI Listing
January 2006

Adeno-associated virus vectors: potential applications for cancer gene therapy.

Cancer Gene Ther 2005 Dec;12(12):913-25

Gene Therapy Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1038/sj.cgt.7700876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1361306PMC
December 2005

Selective evolution of stromal mesenchyme with p53 loss in response to epithelial tumorigenesis.

Cell 2005 Dec;123(6):1001-11

Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1016/j.cell.2005.09.030DOI Listing
December 2005

Heterogeneous tumor evolution initiated by loss of pRb function in a preclinical prostate cancer model.

Cancer Res 2005 Nov;65(22):10243-54

Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-05-1579DOI Listing
November 2005

Magnetic resonance angiography visualization of abnormal tumor vasculature in genetically engineered mice.

Cancer Res 2005 Sep;65(18):8218-23

Department of Radiology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-4355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430271PMC
September 2005

Somatic induction of Pten loss in a preclinical astrocytoma model reveals major roles in disease progression and avenues for target discovery and validation.

Cancer Res 2005 Jun;65(12):5172-80

Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-3902DOI Listing
June 2005

p53 must be competent for transcriptional regulation to suppress tumor formation.

Oncogene 2005 May;24(22):3563-73

Department of Oncology-Pathology, Karolinska Institutet, CCK R8:05, Karolinska University Hospital, 171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1038/sj.onc.1208354DOI Listing
May 2005

Cancer biology: sense out of missense.

Authors:
Terry Van Dyke

Nature 2005 Mar;434(7031):287-8

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http://dx.doi.org/10.1038/434287aDOI Listing
March 2005

Dietary depletion of vitamin E and vitamin A inhibits mammary tumor growth and metastasis in transgenic mice.

J Nutr 2004 May;134(5):1139-44

Department of Nutrition, School of Public Health, University of North Carolina, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1093/jn/134.5.1139DOI Listing
May 2004

pRb inactivation in mammary cells reveals common mechanisms for tumor initiation and progression in divergent epithelia.

PLoS Biol 2004 Feb 17;2(2):E22. Epub 2004 Feb 17.

Department of Genetics, Lineberger Comprehensive Cancer Center, The University of North Carolina School of Medicine, Chapel Hill, USA.

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http://dx.plos.org/10.1371/journal.pbio.0020022
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http://dx.doi.org/10.1371/journal.pbio.0020022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC340938PMC
February 2004

Pten dose dictates cancer progression in the prostate.

PLoS Biol 2003 Dec 27;1(3):E59. Epub 2003 Oct 27.

Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Institute, New York, New York, USA.

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https://dx.plos.org/10.1371/journal.pbio.0000059
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http://dx.doi.org/10.1371/journal.pbio.0000059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC270016PMC
December 2003

Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation.

Cancer Cell 2002 Mar;1(2):157-68

Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1016/s1535-6108(02)00029-6DOI Listing
March 2002

p19(ARF) is dispensable for oncogenic stress-induced p53-mediated apoptosis and tumor suppression in vivo.

Mol Cell Biol 2002 Jan;22(1):370-7

Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC134227PMC
http://dx.doi.org/10.1128/mcb.22.1.370-377.2002DOI Listing
January 2002

Sensing of intermediates in V(D)J recombination by ATM.

Genes Dev 2002 Jan;16(2):159-64

Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1101/gad.956902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC155324PMC
January 2002

Cancer modeling in the modern era: progress and challenges.

Cell 2002 Jan;108(2):135-44

Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1016/s0092-8674(02)00621-9DOI Listing
January 2002