Tero Aittokallio

Tero Aittokallio

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Tero Aittokallio

Publications by authors named "Tero Aittokallio"

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Novel Screening Method Identifies PI3Kα, mTOR, and IGF1R as Key Kinases Regulating Cardiomyocyte Survival.

J Am Heart Assoc 2019 Nov 16;8(21):e013018. Epub 2019 Oct 16.

Research Unit of Biomedicine Department of Pharmacology and Toxicology University of Oulu Finland.

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http://dx.doi.org/10.1161/JAHA.119.013018DOI Listing
November 2019

Chemogenomic Analysis of the Druggable Kinome and Its Application to Repositioning and Lead Identification Studies.

Cell Chem Biol 2019 Sep 10. Epub 2019 Sep 10.

Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki 00014, Finland; Department of Mathematics and Statistics, University of Turku, Turku 20014, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2019.08.007DOI Listing
September 2019

Genome-wide off-targets of drugs: risks and opportunities.

Cell Biol Toxicol 2019 Aug 20. Epub 2019 Aug 20.

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, FI-00290, Helsinki, Finland.

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http://dx.doi.org/10.1007/s10565-019-09491-7DOI Listing
August 2019

Phenotypic Screening Combined with Machine Learning for Efficient Identification of Breast Cancer-Selective Therapeutic Targets.

Cell Chem Biol 2019 Jul 2;26(7):970-979.e4. Epub 2019 May 2.

Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, 00290 Helsinki, Finland; Biotech Research & Innovation Centre (BRIC) and Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), University of Copenhagen, 2200 Copenhagen N, Denmark. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S24519456193010
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http://dx.doi.org/10.1016/j.chembiol.2019.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642004PMC
July 2019

Integrated Analysis of Drug Sensitivity and Selectivity to Predict Synergistic Drug Combinations and Target Coaddictions in Cancer.

Methods Mol Biol 2019 ;1888:205-217

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1007/978-1-4939-8891-4_12DOI Listing
June 2019

DNMT Inhibitors Increase Methylation in the Cancer Genome.

Front Pharmacol 2019 24;10:385. Epub 2019 Apr 24.

Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.3389/fphar.2019.00385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491738PMC
April 2019

Machine learning and feature selection for drug response prediction in precision oncology applications.

Biophys Rev 2019 Feb 10;11(1):31-39. Epub 2018 Aug 10.

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, FI-00290, Helsinki, Finland.

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http://dx.doi.org/10.1007/s12551-018-0446-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381361PMC
February 2019

Adrenals Contribute to Growth of Castration-Resistant VCaP Prostate Cancer Xenografts.

Am J Pathol 2018 12 28;188(12):2890-2901. Epub 2018 Sep 28.

Research Centre for Integrative Physiology and Pharmacology, University of Turku, Turku, Finland; Turku Center for Disease Modeling, University of Turku, Turku, Finland; Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2018.07.029DOI Listing
December 2018

Interactive visual analysis of drug-target interaction networks using Drug Target Profiler, with applications to precision medicine and drug repurposing.

Brief Bioinform 2018 Dec 18. Epub 2018 Dec 18.

Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1093/bib/bby119DOI Listing
December 2018

Methods for High-throughput Drug Combination Screening and Synergy Scoring.

Methods Mol Biol 2018 ;1711:351-398

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, PO Box 33, Helsinki, 00014, Finland.

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http://dx.doi.org/10.1007/978-1-4939-7493-1_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383747PMC
October 2018

Drug-Sensitivity Screening and Genomic Characterization of 45 HPV-Negative Head and Neck Carcinoma Cell Lines for Novel Biomarkers of Drug Efficacy.

Mol Cancer Ther 2018 09 3;17(9):2060-2071. Epub 2018 Jul 3.

Research Programs Unit, Genome-Scale Biology Program and Medicum, Biochemistry and Developmental Biology, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1158/1535-7163.MCT-17-0733DOI Listing
September 2018

Immune cell contexture in the bone marrow tumor microenvironment impacts therapy response in CML.

Leukemia 2018 07 20;32(7):1643-1656. Epub 2018 Jun 20.

Hematology Research Unit Helsinki, University of Helsinki and Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.

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http://dx.doi.org/10.1038/s41375-018-0175-0DOI Listing
July 2018

Learning with multiple pairwise kernels for drug bioactivity prediction.

Bioinformatics 2018 07;34(13):i509-i518

Department of Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Espoo, Finland.

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http://dx.doi.org/10.1093/bioinformatics/bty277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022556PMC
July 2018

Patient-Customized Drug Combination Prediction and Testing for T-cell Prolymphocytic Leukemia Patients.

Cancer Res 2018 05 26;78(9):2407-2418. Epub 2018 Feb 26.

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-3644DOI Listing
May 2018

Global proteomics profiling improves drug sensitivity prediction: results from a multi-omics, pan-cancer modeling approach.

Bioinformatics 2018 04;34(8):1353-1362

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00290 Helsinki, Finland.

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http://dx.doi.org/10.1093/bioinformatics/btx766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905617PMC
April 2018

Combined ASRGL1 and p53 immunohistochemistry as an independent predictor of survival in endometrioid endometrial carcinoma.

Gynecol Oncol 2018 04 2;149(1):173-180. Epub 2018 Mar 2.

Department of Gynaecology and Obstetrics, University of Tampere, Tampere University Hospital, PL2000, 33521 Tampere, Finland.

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http://dx.doi.org/10.1016/j.ygyno.2018.02.016DOI Listing
April 2018

Improving the efficacy-safety balance of polypharmacology in multi-target drug discovery.

Expert Opin Drug Discov 2018 02 12;13(2):179-192. Epub 2017 Dec 12.

a Institute for Molecular Medicine Finland , FIMM, University of Helsinki , Helsinki , Finland.

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http://dx.doi.org/10.1080/17460441.2018.1413089DOI Listing
February 2018

Antiandrogens Reduce Intratumoral Androgen Concentrations and Induce Androgen Receptor Expression in Castration-Resistant Prostate Cancer Xenografts.

Am J Pathol 2018 01 7;188(1):216-228. Epub 2017 Nov 7.

Department of Physiology, Institute of Biomedicine, University of Turku, Turku, Finland; Turku Center for Disease Modeling, Institute of Biomedicine, University of Turku, Turku, Finland; Center for Bone and Arthritis Research, The Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029440173053
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http://dx.doi.org/10.1016/j.ajpath.2017.08.036DOI Listing
January 2018

In Search of System-Wide Productivity Gains - The Role of Global Collaborations in Preclinical Translation.

Clin Transl Sci 2017 11 19;10(6):423-425. Epub 2017 Sep 19.

EATRIS ERIC, European Infrastructure for Translational Medicine, Amsterdam, 1081, HZ, Netherlands.

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http://dx.doi.org/10.1111/cts.12498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402186PMC
November 2017

Orphan G protein-coupled receptor GPRC5A modulates integrin β1-mediated epithelial cell adhesion.

Cell Adh Migr 2017 Sep 6;11(5-6):434-446. Epub 2017 Feb 6.

a Institute for Molecular Medicine Finland (FIMM), University of Helsinki , Helsinki , Finland.

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http://dx.doi.org/10.1080/19336918.2016.1245264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810789PMC
September 2017

Re: Fatemeh Seyednasrollah, Mehrad Mahmoudian, Liisa Rautakorpi, et al. How Reliable are Trial-based Prognostic Models in Real-world Patients with Metastatic Castration-resistant Prostate Cancer? Eur Urol. 2017;71:838-40.

Eur Urol 2017 09 9;72(3):e68-e69. Epub 2017 May 9.

Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland; Department of Mathematics and Statistics, University of Turku, Turku, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2017.04.030DOI Listing
September 2017

Early metabolic markers identify potential targets for the prevention of type 2 diabetes.

Diabetologia 2017 09 8;60(9):1740-1750. Epub 2017 Jun 8.

Institute for Molecular Medicine Finland (FIMM), Nordic EMBL Partnership for Molecular Medicine, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1007/s00125-017-4325-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552834PMC
September 2017

MediSyn: uncertainty-aware visualization of multiple biomedical datasets to support drug treatment selection.

BMC Bioinformatics 2017 Sep 13;18(Suppl 10):393. Epub 2017 Sep 13.

Helsinki Institute for Information Technology HIIT, Department of Computer Science, University of Helsinki, Gustaf Hällströmin katu 2b, Helsinki, 00560, Finland.

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http://dx.doi.org/10.1186/s12859-017-1785-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606218PMC
September 2017

The inconvenience of data of convenience: computational research beyond post-mortem analyses.

Nat Methods 2017 09;14(10):937-938

Genetics and Genome Biology, SickKids Research Institute, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/nmeth.4457DOI Listing
September 2017

SynergyFinder: a web application for analyzing drug combination dose-response matrix data.

Bioinformatics 2017 Aug;33(15):2413-2415

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, FI-00290 Helsinki, Finland.

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http://dx.doi.org/10.1093/bioinformatics/btx162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554616PMC
August 2017

C-SPADE: a web-tool for interactive analysis and visualization of drug screening experiments through compound-specific bioactivity dendrograms.

Nucleic Acids Res 2017 07;45(W1):W495-W500

Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1093/nar/gkx384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570255PMC
July 2017

Matched preclinical designs for improved translatability.

Sci Transl Med 2017 05;9(389)

Tero Aittokallio is an EMBL Group Leader at the Institute for Molecular Medicine Finland (FIMM), University of Helsinki, FI 00014 Helsinki, Finland, and a Professor in the Department of Mathematics and Statistics, University of Turku, FI 20014 Turku, Finland.

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http://dx.doi.org/10.1126/scitranslmed.aal4101DOI Listing
May 2017

Consistency in drug response profiling.

Nature 2016 11;540(7631):E5-E6

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00290 Helsinki, Finland.

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http://dx.doi.org/10.1038/nature20171DOI Listing
November 2016

Phosphoproteomics to Characterize Host Response During Influenza A Virus Infection of Human Macrophages.

Mol Cell Proteomics 2016 10 2;15(10):3203-3219. Epub 2016 Aug 2.

From the ‡Institute of Biotechnology, FI-00014 University of Helsinki, Helsinki, Finland; ¶¶Institute of Clinical Medicine, University of Oslo, Norway

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http://dx.doi.org/10.1074/mcp.M116.057984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054344PMC
October 2016

The Hydroxysteroid (17β) Dehydrogenase Family Gene HSD17B12 Is Involved in the Prostaglandin Synthesis Pathway, the Ovarian Function, and Regulation of Fertility.

Endocrinology 2016 Oct 4;157(10):3719-3730. Epub 2016 Aug 4.

Department of Physiology and Turku Center for Disease Modeling (H.K., M.A., J.M.-J., T.D.L., L.S., M.P.), Institute of Biomedicine, University of Turku, FI-20540 Turku, Finland; Department of Clinical Science, Intervention and Technology (P.D., O.H.), Karolinska Institute, 141 52 Huddinge, Sweden; Swedish Toxicology Sciences Research Center (P.D.), Karolinska Institutet, 141 86 Stockholm, Sweden; Department of Biosciences and Nutrition (A.E.D., J.K.), Karolinska Institutet, 171 77 Stockholm, Sweden; Department of Mathematics and Statistics (T.D.L., T.A.), University of Turku, FI-20014 Turku, Finland; Institute for Molecular Medicine Finland (T.A.), University of Helsinki, FI-00014 Helsinki, Finland; Experimental Genetics (J.A.), Center of Life and Food Sciences, Weihenstephan, 85354 Freising, Germany; Institute of experimental Genetics (J.A.), Helmholtz Zentrum, 81377 München, Germany; Genome Analysis Center (J.A.), German Research Center for Environmental Health, 85764 Neuherberg, Germany; Institute of Neuroscience and Physiology (H.R.), Sahlgrenska Academy, University of Gothenburg, SE-405 30 Gothenburg, Sweden; Institute of Medicine (C.O., M.P.), The Sahlgrenska Academy, University of Gothenburg, SE-413 46 Gothenburg, Sweden.

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http://dx.doi.org/10.1210/en.2016-1252DOI Listing
October 2016

Erratum: Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis.

Nat Commun 2016 10 10;7:13205. Epub 2016 Oct 10.

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http://dx.doi.org/10.1038/ncomms13205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062501PMC
October 2016

Drug response prediction by inferring pathway-response associations with kernelized Bayesian matrix factorization.

Bioinformatics 2016 09;32(17):i455-i463

Helsinki Institute for Information Technology HIIT, Department of Computer Science, Aalto University, Espoo 02150, Finland.

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http://dx.doi.org/10.1093/bioinformatics/btw433DOI Listing
September 2016

Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis.

Nat Commun 2016 08 23;7:12460. Epub 2016 Aug 23.

Sage Bionetworks, Seattle, Washington 98115, USA.

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http://dx.doi.org/10.1038/ncomms12460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996969PMC
August 2016

Transcriptional response networks for elucidating mechanisms of action of multitargeted agents.

Drug Discov Today 2016 07 12;21(7):1063-75. Epub 2016 Mar 12.

Institute for Molecular Medicine Finland (FIMM), Biomedicum Helsinki 2U, Tukholmankatu 8, University of Helsinki, Helsinki 00014, Finland; Department of Mathematics and Statistics, Quantum, University of Turku, Turku 20014, Finland.

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http://dx.doi.org/10.1016/j.drudis.2016.03.001DOI Listing
July 2016

Systematic Identification of MicroRNAs That Impact on Proliferation of Prostate Cancer Cells and Display Changed Expression in Tumor Tissue.

Eur Urol 2016 06 20;69(6):1120-8. Epub 2015 Oct 20.

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland; VTT Technical Research Centre of Finland, Medical Biotechnology, Turku, Finland(1).

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http://dx.doi.org/10.1016/j.eururo.2015.09.019DOI Listing
June 2016

Searching for Drug Synergy in Complex Dose-Response Landscapes Using an Interaction Potency Model.

Comput Struct Biotechnol J 2015 25;13:504-13. Epub 2015 Sep 25.

Institute for Molecular Medicine Finland (FIMM), FI-00014, University of Helsinki, Finland.

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http://dx.doi.org/10.1016/j.csbj.2015.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759128PMC
March 2016

Liver lipid metabolism is altered by increased circulating estrogen to androgen ratio in male mouse.

J Proteomics 2016 Feb 9;133:66-75. Epub 2015 Dec 9.

Department of Physiology, Institute of Biomedicine, University of Turku, Turku, Finland; Turku Center for Disease Modeling, University of Turku, Turku, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.jprot.2015.12.009DOI Listing
February 2016

Identification of drug candidates and repurposing opportunities through compound-target interaction networks.

Expert Opin Drug Discov 2015 Dec 1;10(12):1333-45. Epub 2015 Oct 1.

d 4 University of Helsinki, Institute for Molecular Medicine Finland FIMM , Helsinki, Finland +358 5 03 18 24 26 ;

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http://dx.doi.org/10.1517/17460441.2015.1096926DOI Listing
December 2015

Relevance Rank Platform (RRP) for Functional Filtering of High Content Protein-Protein Interaction Data.

Mol Cell Proteomics 2015 Dec 23;14(12):3274-83. Epub 2015 Oct 23.

From the ‡Institute for Molecular Medicine Finland FIMM, University of Helsinki, PO Box 20, FIN-00014 Helsinki, Finland; §Centre for Biotechnology, ¶Department of Pathology,University of Turku and Åbo Akademi, Turku, Finland, PO Box 123, FIN-20521 Turku, Finland.;

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http://dx.doi.org/10.1074/mcp.M115.050773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762622PMC
December 2015

From drug response profiling to target addiction scoring in cancer cell models.

Dis Model Mech 2015 Oct;8(10):1255-64

Institute for Molecular Medicine Finland (FIMM), Nordic EMBL Partnership for Molecular Medicine, University of Helsinki, FI-00014 Helsinki, Finland

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http://dx.doi.org/10.1242/dmm.021105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610238PMC
October 2015

What is synergy? The Saariselkä agreement revisited.

Front Pharmacol 2015 1;6:181. Epub 2015 Sep 1.

Institute for Molecular Medicine Finland (FIMM), University of Helsinki Helsinki, Finland.

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http://journal.frontiersin.org/article/10.3389/fphar.2015.00
Publisher Site
http://dx.doi.org/10.3389/fphar.2015.00181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555011PMC
September 2015

Network pharmacology applications to map the unexplored target space and therapeutic potential of natural products.

Nat Prod Rep 2015 Aug;32(8):1249-66

Institute for Molecular Medicine Finland (FIMM), Biomedicum Helsinki 2U, 00014 University of Helsinki, Finland.

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http://dx.doi.org/10.1039/c5np00005jDOI Listing
August 2015

Systematic Mapping of Kinase Addiction Combinations in Breast Cancer Cells by Integrating Drug Sensitivity and Selectivity Profiles.

Chem Biol 2015 Aug 23;22(8):1144-55. Epub 2015 Jul 23.

Institute for Molecular Medicine Finland, FIMM, University of Helsinki, 00014 Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2015.06.021DOI Listing
August 2015

Label-free quantitative phosphoproteomics with novel pairwise abundance normalization reveals synergistic RAS and CIP2A signaling.

Sci Rep 2015 Aug 17;5:13099. Epub 2015 Aug 17.

1] Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Tykistokatu 6, FI-20520 Turku, Finland [2] Faculty of Pharmacy, Meijo University, Yagotoyama 150, Tempaku, Nagoya 468-8503, Japan.

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http://dx.doi.org/10.1038/srep13099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642524PMC
August 2015

Novel Lignan and stilbenoid mixture shows anticarcinogenic efficacy in preclinical PC-3M-luc2 prostate cancer model.

PLoS One 2014 3;9(4):e93764. Epub 2014 Apr 3.

Functional Foods Forum, University of Turku, Turku, Finland; Turku Center for Disease Modeling (TCDM), Institute of Biomedicine, University of Turku, Turku, Finland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0093764PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974786PMC
January 2015

Ovarian endometriosis signatures established through discovery and directed mass spectrometry analysis.

J Proteome Res 2014 Nov 20;13(11):4983-94. Epub 2014 Aug 20.

Turku Centre for Biotechnology, ‡Department of Physiology, Institute of Biomedicine, ⊥Department of Mathematics and Statistics, and ¶Turku Center for Disease Modeling, University of Turku , Turku, Finland.

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http://dx.doi.org/10.1021/pr500384nDOI Listing
November 2014

Intra-tissue steroid profiling indicates differential progesterone and testosterone metabolism in the endometrium and endometriosis lesions.

J Clin Endocrinol Metab 2014 Nov 19;99(11):E2188-97. Epub 2014 Aug 19.

Department of Physiology (K.H., T.S.-H., D.L., M.S., M.A., A.P., M.P.), Institute of Biomedicine, University of Turku, 20014 Turku, Finland; Department of Obstetrics and Gynecology (K.H., P.S., A.P.), University of Turku, 20014 Turku, Finland; School of Pharmacy, University of Eastern Finland (P.K.-R., M.R.H., S.A.), 70211 Kuopio, Finland; ANZAC Research Institute (R.D., D.J.H.), Concord Hospital, University of Sydney, 2139, Australia; Institute for Molecular Medicine Finland (D.L., T.A.), University of Helsinki, 00014 Helsinki, Finland; Department of Pathology (H.K.), Institute of Biomedicine, University of Turku, 20014 Turku, Finland; Turku Center for Disease Modeling (M.P.), University of Turku, 20014 Turku, Finland; and Institute of Medicine (M.P.), The Sahlgrenska Academy, Gothenburg University, 413 45 Gothenburg, Sweden.

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http://dx.doi.org/10.1210/jc.2014-1913DOI Listing
November 2014

Statistical detection of quantitative protein biomarkers provides insights into signaling networks deregulated in acute myeloid leukemia.

Proteomics 2014 Nov 15;14(21-22):2443-53. Epub 2014 Oct 15.

Department of Mathematics and Statistics, University of Turku, Turku, Finland; Turku Centre for Biotechnology, Turku, Finland.

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http://dx.doi.org/10.1002/pmic.201300460DOI Listing
November 2014

Regularized machine learning in the genetic prediction of complex traits.

PLoS Genet 2014 Nov 13;10(11):e1004754. Epub 2014 Nov 13.

Turku Centre for Computer Science (TUCS), University of Turku and Åbo Akademi University, Turku, Finland; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1371/journal.pgen.1004754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230844PMC
November 2014

Castration induces up-regulation of intratumoral androgen biosynthesis and androgen receptor expression in an orthotopic VCaP human prostate cancer xenograft model.

Am J Pathol 2014 Aug 17;184(8):2163-73. Epub 2014 Jun 17.

Turku Center for Disease Modeling, Institute of Biomedicine, University of Turku, Turku, Finland; Functional Foods Forum, University of Turku, Turku, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2014.04.010DOI Listing
August 2014

PhosFox: a bioinformatics tool for peptide-level processing of LC-MS/MS-based phosphoproteomic data.

Proteome Sci 2014 26;12:36. Epub 2014 Jun 26.

Institute of Biotechnology, University of Helsinki, P.O. Box 65 (Viikinkaari 1), FI-00014 Helsinki, Finland.

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http://dx.doi.org/10.1186/1477-5956-12-36DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4098950PMC
July 2014

Target inhibition networks: predicting selective combinations of druggable targets to block cancer survival pathways.

PLoS Comput Biol 2013 12;9(9):e1003226. Epub 2013 Sep 12.

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1371/journal.pcbi.1003226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772058PMC
April 2014

Making sense of large-scale kinase inhibitor bioactivity data sets: a comparative and integrative analysis.

J Chem Inf Model 2014 Mar 21;54(3):735-43. Epub 2014 Feb 21.

Institute for Molecular Medicine Finland (FIMM), University of Helsinki , Tukholmankatu 8, FI-00290, Helsinki, Finland.

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http://dx.doi.org/10.1021/ci400709dDOI Listing
March 2014

Individualized systems medicine strategy to tailor treatments for patients with chemorefractory acute myeloid leukemia.

Cancer Discov 2013 Dec 20;3(12):1416-29. Epub 2013 Sep 20.

1Institute for Molecular Medicine Finland, FIMM; 2Hematology Research Unit Helsinki, Helsinki University Central Hospital, University of Helsinki, Helsinki; 3Department of Clinical Chemistry and TYKSLAB, Turku University Central Hospital, University of Turku, Turku; 4Department of Internal Medicine, Tampere University Hospital, Tampere, Finland; 5Department of Clinical Science, Hematology Section, University of Bergen; and 6Department of Internal Medicine, Hematology Section, Haukeland University Hospital, Bergen, Norway.

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http://dx.doi.org/10.1158/2159-8290.CD-13-0350DOI Listing
December 2013

Chk1 targeting reactivates PP2A tumor suppressor activity in cancer cells.

Cancer Res 2013 Nov 26;73(22):6757-69. Epub 2013 Sep 26.

Authors' Affiliations: Institute of Biomedical Technology and BioMediTech, University of Tampere and Tampere University Hospital; Tampere Graduate Program in Biomedicine and Biotechnology (TGPBB), University of Tampere, Tampere; Turku Centre for Biotechnology, University of Turku and Åbo Akademi University; Department of Pathology, University of Turku; Turku Doctoral Program of Biomedical Sciences (TuBS), Turku; Department of Pathology, HUSLAB and Haartman Institute, Helsinki University, Central Hospital and University of Helsinki; University of Helsinki Institute of Biomedicine and Genome-Scale Biology Research Program; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland; Karlsruhe Institute of Technology, Campus North, Institute of Toxicology and Genetics, Karlsruhe, Germany; Adult Cancer Program, Lowy Cancer Centre and Prince of Wales Hospital, UNSW Medicine, University of New South Wales, Sydney, Australia; Department of Medical Biology and Genetics, Faculty of Medicine, Akdeniz University, Antalya, Turkey; Division of Oncology, Children's Hospital of Philadelphia; and Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-1002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870284PMC
November 2013

Predicting drug-target interactions through integrative analysis of chemogenetic assays in yeast.

Mol Biosyst 2013 Apr;9(4):768-79

Biomathematics Research Group, Department of Mathematics, University of Turku, FI-20014, Finland.

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http://dx.doi.org/10.1039/c3mb25591cDOI Listing
April 2013

Genetic variants and their interactions in disease risk prediction - machine learning and network perspectives.

BioData Min 2013 Mar 1;6(1). Epub 2013 Mar 1.

Turku Centre for Computer Science (TUCS), Turku, Finland.

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http://dx.doi.org/10.1186/1756-0381-6-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606427PMC
March 2013

Wrapper-based selection of genetic features in genome-wide association studies through fast matrix operations.

Algorithms Mol Biol 2012 May 2;7(1):11. Epub 2012 May 2.

Department of Information Technology, University of Turku, Turku, Finland.

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http://dx.doi.org/10.1186/1748-7188-7-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606421PMC
May 2012

The rocky road to personalized medicine: computational and statistical challenges.

Per Med 2012 Mar;9(2):109-114

Helsinki Institute for Information Technology, Aalto University, 00076 Aalto, Finland and Helsinki Institute for Information Technology, University of Helsinki, Finland.

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http://dx.doi.org/10.2217/pme.12.1DOI Listing
March 2012