Publications by authors named "Teresa W M Fan"

91Publications

Fumarate hydratase-deficient renal cell carcinoma cells respond to asparagine by activation of the unfolded protein response and stimulation of the hexosamine biosynthetic pathway.

Cancer Metab 2020 3;8. Epub 2020 Aug 3.

Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, NCI Shady Grove Room 5 W460, 9609 Medical Center Drive, Bethesda, MD 20892-9739 USA.

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http://dx.doi.org/10.1186/s40170-020-00214-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397616PMC
August 2020

Loss of CLN3, the gene mutated in juvenile neuronal ceroid lipofuscinosis, leads to metabolic impairment and autophagy induction in retinal pigment epithelium.

Biochim Biophys Acta Mol Basis Dis 2020 Oct 25;1866(10):165883. Epub 2020 Jun 25.

Department of Ophthalmology and Visual Sciences, University of Kentucky, Lexington, KY, United States; Markey Cancer Center, University of Kentucky, Lexington, KY, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2020.165883DOI Listing
October 2020

NMR and MS-based Stable Isotope-Resolved Metabolomics and Applications in Cancer Metabolism.

Trends Analyt Chem 2019 Nov 24;120. Epub 2018 Nov 24.

Center for Environmental and Systems Biochemistry, Dept. Toxicology and Cancer Biology, Markey Cancer Center, University of Kentucky, 789 S. Limestone St., Lexington, KY 40536 USA.

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http://dx.doi.org/10.1016/j.trac.2018.11.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286614PMC
November 2019

Applications of Chromatography-Ultra High-Resolution MS for Stable Isotope-Resolved Metabolomics (SIRM) Reconstruction of Metabolic Networks.

Trends Analyt Chem 2020 Feb 1;123. Epub 2019 Oct 1.

Center for Environmental and Systems Biochemistry (CESB), University of Kentucky, Lexington, KY, 40539, USA.

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http://dx.doi.org/10.1016/j.trac.2019.115676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263348PMC
February 2020

Metabolic reprogramming in tumors: Contributions of the tumor microenvironment.

Genes Dis 2020 Jun 23;7(2):185-198. Epub 2019 Oct 23.

Center for Environmental and Systems Biochemistry, Markey Cancer Center, Department of Toxicology and Cancer Biology, University of Kentucky, USA.

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http://dx.doi.org/10.1016/j.gendis.2019.10.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083762PMC
June 2020

Regulation of hepatic glutamine metabolism by miR-122.

Mol Metab 2020 04 9;34:174-186. Epub 2020 Jan 9.

Department of Pathology, The Ohio State University College of Medicine, Columbus, OH, USA; Comprehensive Cancer Center, The Ohio State University College of Medicine, Columbus, OH, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2020.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044666PMC
April 2020

Author Correction: Air pollution-derived particulate matter dysregulates hepatic Krebs cycle, glucose and lipid metabolism in mice.

Sci Rep 2020 Mar 16;10(1):5082. Epub 2020 Mar 16.

Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, 615N. Wolfe Street, Baltimore, MD, 21205, USA.

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http://dx.doi.org/10.1038/s41598-020-60083-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076005PMC
March 2020

Software Supporting a Workflow of Quantitative Dynamic Flux Maps Estimation in Central Metabolism from SIRM Experimental Data.

Methods Mol Biol 2020 ;2088:271-298

Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, Universitat de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1007/978-1-0716-0159-4_12DOI Listing
January 2020

Air pollution-derived particulate matter dysregulates hepatic Krebs cycle, glucose and lipid metabolism in mice.

Sci Rep 2019 11 22;9(1):17423. Epub 2019 Nov 22.

Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, 615N. Wolfe Street, Baltimore, MD, 21205, USA.

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http://dx.doi.org/10.1038/s41598-019-53716-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874681PMC
November 2019

SDA: a semi-parametric differential abundance analysis method for metabolomics and proteomics data.

BMC Bioinformatics 2019 Oct 17;20(1):501. Epub 2019 Oct 17.

Markey Cancer Center, University of Kentucky, Lexington, 40536, USA.

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http://dx.doi.org/10.1186/s12859-019-3067-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6798423PMC
October 2019

Stable Isotope-Resolved Metabolomics by NMR.

Methods Mol Biol 2019 ;2037:151-168

Center for Environmental and Systems Biochemistry, University of Kentucky, Lexington, KY, USA.

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http://dx.doi.org/10.1007/978-1-4939-9690-2_9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256830PMC
April 2020

Improved segmented-scan spectral stitching for stable isotope resolved metabolomics (SIRM) by ultra-high-resolution Fourier transform mass spectrometry.

Anal Chim Acta 2019 Nov 11;1080:104-115. Epub 2019 Jun 11.

Center for Environmental and Systems Biochemistry (CESB), Markey Cancer Center, Department of Toxicology and Cancer Biology, University of Kentucky, United States. Electronic address:

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http://dx.doi.org/10.1016/j.aca.2019.06.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153561PMC
November 2019

Inferring Gene Regulatory Networks of Metabolic Enzymes Using Gradient Boosted Trees.

IEEE J Biomed Health Inform 2020 05 30;24(5):1528-1536. Epub 2019 Jul 30.

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http://dx.doi.org/10.1109/JBHI.2019.2931997DOI Listing
May 2020

synthesis of serine and glycine fuels purine nucleotide biosynthesis in human lung cancer tissues.

J Biol Chem 2019 09 23;294(36):13464-13477. Epub 2019 Jul 23.

Center for Environmental and Systems Biochemistry (CESB)/Markey Cancer Center, University of Kentucky, Lexington, Kentucky 40536

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http://dx.doi.org/10.1074/jbc.RA119.008743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737211PMC
September 2019

Inhibition of Anaplerotic Glutaminolysis Underlies Selenite Toxicity in Human Lung Cancer.

Proteomics 2019 11 12;19(21-22):e1800486. Epub 2019 Sep 12.

Center for Environmental and Systems Biochemistry, Markey Cancer Center, and Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY, 40536-0596, USA.

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http://dx.doi.org/10.1002/pmic.201800486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153719PMC
November 2019

Metabolic Labeling of Cultured Mammalian Cells for Stable Isotope-Resolved Metabolomics: Practical Aspects of Tissue Culture and Sample Extraction.

Methods Mol Biol 2019 ;1928:1-27

Urologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1007/978-1-4939-9027-6_1DOI Listing
June 2019

Photoinducible Oncometabolite Detection.

Chembiochem 2019 02 13;20(3):360-365. Epub 2018 Dec 13.

Chemical Biology Laboratory, National Cancer Institute, NIH, Frederick, MD, 21702, USA.

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http://dx.doi.org/10.1002/cbic.201800651DOI Listing
February 2019

Exosomal lipids for classifying early and late stage non-small cell lung cancer.

Anal Chim Acta 2018 Dec 9;1037:256-264. Epub 2018 Mar 9.

Center for Environmental and Systems Biochemistry (CESB), Markey Cancer Center, Department of Toxicology and Cancer Biology, University of Kentucky, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00032670183027
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http://dx.doi.org/10.1016/j.aca.2018.02.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582997PMC
December 2018

Stable Isotope-Resolved Metabolomics Shows Metabolic Resistance to Anti-Cancer Selenite in 3D Spheroids versus 2D Cell Cultures.

Metabolites 2018 Jul 10;8(3). Epub 2018 Jul 10.

Center for Environmental and Systems Biochemistry, Markey Cancer Center, and Depart of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY 40506, USA.

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http://dx.doi.org/10.3390/metabo8030040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161115PMC
July 2018

Correction: Quantitative profiling of carbonyl metabolites directly in crude biological extracts using chemoselective tagging and nanoESI-FTMS.

Analyst 2018 02;143(4):999

Center for Environmental and Systems Biochemistry, Markey Cancer Center, and Dept. Toxicology & Cancer Biology, University of Kentucky, Lexington, Kentucky 40536-0596, USA.

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http://dx.doi.org/10.1039/c8an90009dDOI Listing
February 2018

Quantitative profiling of carbonyl metabolites directly in crude biological extracts using chemoselective tagging and nanoESI-FTMS.

Analyst 2017 12;143(1):311-322

Center for Environmental and Systems Biochemistry, Markey Cancer Center, and Dept. Toxicology & Cancer Biology, University of Kentucky, Lexington, Kentucky 40536-0596, USA.

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http://dx.doi.org/10.1039/c7an01256jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759371PMC
December 2017

Noninvasive liquid diet delivery of stable isotopes into mouse models for deep metabolic network tracing.

Nat Commun 2017 11 21;8(1):1646. Epub 2017 Nov 21.

Center for Environmental and Systems Biochemistry, University of Kentucky, 789S. Limestone St., Lexington, KY, 40536, USA.

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http://dx.doi.org/10.1038/s41467-017-01518-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696342PMC
November 2017

Glycolytic reprogramming through PCK2 regulates tumor initiation of prostate cancer cells.

Oncotarget 2017 Oct 28;8(48):83602-83618. Epub 2017 Jun 28.

The Basic Research Laboratory, National Cancer Institute, National Institutes of Health Frederick, Frederick, MD 21702, USA.

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http://dx.doi.org/10.18632/oncotarget.18787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663539PMC
October 2017

Selenium toxicity to survival and reproduction of Collembola and Enchytraeids in a sandy loam soil.

Environ Toxicol Chem 2018 03 4;37(3):846-853. Epub 2018 Jan 4.

US Environmental Protection Agency, Office of Research and Development, Washington, DC, USA.

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http://dx.doi.org/10.1002/etc.4017DOI Listing
March 2018

Exploring cancer metabolism using stable isotope-resolved metabolomics (SIRM).

J Biol Chem 2017 07 7;292(28):11601-11609. Epub 2017 Jun 7.

From the Center for Environmental and Systems Biochemistry, Markey Cancer Center, and

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http://dx.doi.org/10.1074/jbc.R117.776054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512057PMC
July 2017

Chloroformate derivatization for tracing the fate of Amino acids in cells and tissues by multiple stable isotope resolved metabolomics (mSIRM).

Anal Chim Acta 2017 Jul 10;976:63-73. Epub 2017 Apr 10.

Center for Environmental and Systems Biochemistry, University of Kentucky, Lexington, KY, 40539, USA; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY, 40539, USA. Electronic address:

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http://dx.doi.org/10.1016/j.aca.2017.04.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638134PMC
July 2017

NMR-based Stable Isotope Resolved Metabolomics in systems biochemistry.

Arch Biochem Biophys 2017 08 2;628:123-131. Epub 2017 Mar 2.

Center for Environmental Systems Biochemistry, University of Kentucky, USA; Department of Toxicology and Cancer Biology, University of Kentucky, USA.

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http://dx.doi.org/10.1016/j.abb.2017.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5545158PMC
August 2017

Probing the metabolic phenotype of breast cancer cells by multiple tracer stable isotope resolved metabolomics.

Metab Eng 2017 09 2;43(Pt B):125-136. Epub 2017 Feb 2.

J.G. Brown Cancer Center, University of Louisville, Louisville, KY, United States; Dept. Chemistry and Center for Regulatory and Environmental Analytical Metabolomics, University of Louisville, Louisville, KY, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ymben.2017.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540847PMC
September 2017

Ketogenesis contributes to intestinal cell differentiation.

Cell Death Differ 2017 03 9;24(3):458-468. Epub 2016 Dec 9.

Markey Cancer Center, University of Kentucky, Lexington, KY, USA.

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http://dx.doi.org/10.1038/cdd.2016.142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344206PMC
March 2017

Distinctly perturbed metabolic networks underlie differential tumor tissue damages induced by immune modulator β-glucan in a two-case ex vivo non-small-cell lung cancer study.

Cold Spring Harb Mol Case Stud 2016 Jul;2(4):a000893

Center for Environmental and Systems Biochemistry, Department of Toxicology and Cancer Biology and Markey Cancer Center, University of Kentucky, Lexington, Kentucky 40536, USA;

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http://dx.doi.org/10.1101/mcs.a000893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990809PMC
July 2016

Preclinical models for interrogating drug action in human cancers using Stable Isotope Resolved Metabolomics (SIRM).

Metabolomics 2016 Jul 29;12(7). Epub 2016 Jun 29.

Center for Environmental and Systems Biochemistry, University of Kentucky.

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http://dx.doi.org/10.1007/s11306-016-1065-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968890PMC
July 2016

Stable Isotope Resolved Metabolomics Studies TIssue Slices.

Bio Protoc 2016 Feb;6(3)

Center for Environmental Systems Biochemistry, Dept. Toxicology and Cancer Biology and Markey Cancer Center, 789 S. Limestone St., Lexington KY.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859758PMC
http://dx.doi.org/10.21769/bioprotoc.1730DOI Listing
February 2016

Applications of NMR spectroscopy to systems biochemistry.

Prog Nucl Magn Reson Spectrosc 2016 Feb 6;92-93:18-53. Epub 2016 Feb 6.

Department of Toxicology and Cancer Biology, University of Kentucky, 789 S. Limestone St., Lexington, KY 40536, United States. Electronic address:

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http://dx.doi.org/10.1016/j.pnmrs.2016.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850081PMC
February 2016

C Tracer Studies of Metabolism in Mouse Tumor Xenografts.

Bio Protoc 2015 Nov;5(22)

Center for Environmental Systems Biochemistry, Dept. Toxicology and Cancer Biology and Markey Cancer Center, Lexington, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675468PMC
http://dx.doi.org/10.21769/bioprotoc.1650DOI Listing
November 2015

Dectin-1 Activation by a Natural Product β-Glucan Converts Immunosuppressive Macrophages into an M1-like Phenotype.

J Immunol 2015 Nov 9;195(10):5055-65. Epub 2015 Oct 9.

Division of Hematology/Oncology, Department of Medicine, James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202; Department of Microbiology and Immunology, University of Louisville School of Medicine, Louisville, KY 40202;

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http://dx.doi.org/10.4049/jimmunol.1501158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637216PMC
November 2015

Methylseleninic acid promotes antitumour effects via nuclear FOXO3a translocation through Akt inhibition.

Pharmacol Res 2015 Dec 4;102:218-34. Epub 2015 Nov 4.

Department of Biochemistry and Molecular Biology, Faculty of Biology, Universitat de Barcelona, Av Diagonal 643, Barcelona 08028, Spain; Institute of Biomedicine of Universitat de Barcelona (IBUB) and CSIC-Associated Unit, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2015.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850087PMC
December 2015

Regulation of mammalian nucleotide metabolism and biosynthesis.

Nucleic Acids Res 2015 02 27;43(4):2466-85. Epub 2015 Jan 27.

Graduate Center of Toxicology and Markey Cancer Center, University of Kentucky, Biopharm Complex, 789 S. Limestone St, Lexington, KY 40536, USA.

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http://dx.doi.org/10.1093/nar/gkv047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344498PMC
February 2015

Chemoselective detection and discrimination of carbonyl-containing compounds in metabolite mixtures by 1H-detected 15N nuclear magnetic resonance.

Magn Reson Chem 2015 May 23;53(5):337-43. Epub 2015 Jan 23.

Center for Regulatory and Environmental Analytical Metabolomics, University of Louisville, Louisville, KY, USA; J.G. Brown Cancer Center, University of Louisville, Louisville, KY, USA.

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http://dx.doi.org/10.1002/mrc.4199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409496PMC
May 2015

Stable isotope-labeled tracers for metabolic pathway elucidation by GC-MS and FT-MS.

Methods Mol Biol 2014 ;1198:147-67

Graduate Center of Toxicology, University of Kentucky, Biopharm Complex, 789 S. Limestone St., Lexington, KY, 40536, USA,

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http://dx.doi.org/10.1007/978-1-4939-1258-2_11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337027PMC
June 2015

Development and in silico evaluation of large-scale metabolite identification methods using functional group detection for metabolomics.

Front Genet 2014 28;5:237. Epub 2014 Jul 28.

Department of Molecular and Cellular Biochemistry, Markey Cancer Center, University of Kentucky Lexington, KY, USA.

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http://dx.doi.org/10.3389/fgene.2014.00237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112935PMC
August 2014

Knockdown of malic enzyme 2 suppresses lung tumor growth, induces differentiation and impacts PI3K/AKT signaling.

Sci Rep 2014 Jun 24;4:5414. Epub 2014 Jun 24.

Divisions of Interdisciplinary Medicine and Biotechnology, Hematology-Oncology and Nephrology, Beth Israel Deaconess Medical Center (BIDMC) and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215.

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http://dx.doi.org/10.1038/srep05414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067620PMC
June 2014

Profiling thiol metabolites and quantification of cellular glutathione using FT-ICR-MS spectrometry.

Anal Bioanal Chem 2014 Jul 25;406(18):4371-9. Epub 2014 May 25.

Department of Chemistry, University of Louisville, Louisville, KY, 40292, USA.

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http://dx.doi.org/10.1007/s00216-014-7810-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144182PMC
July 2014

Targeting lactate dehydrogenase--a inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells.

Cell Metab 2014 May 10;19(5):795-809. Epub 2014 Apr 10.

Division of Interdisciplinary Medicine and Biotechnology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA; Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA; Beth Israel Deaconess Cancer Center, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2014.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096909PMC
May 2014

Role in tumor growth of a glycogen debranching enzyme lost in glycogen storage disease.

J Natl Cancer Inst 2014 Apr 3;106(5). Epub 2014 Apr 3.

Affiliations of authors: Department of Surgery (SGui, CP, YR, CRL, JED, GD, CO, DT) and Department of Pharmacology (SGui, CP, YR, CRL, JED, GD, CO, DT), University of Colorado, Denver, CO; Sigma-Aldrich Research Biotech, Saint Louis, MO (AS, SK, HH); Department of Pathology, Cleveland Clinic, Cleveland, OH (SGup, DH); Department of Nutritional Sciences and Toxicology, University of California at Berkeley, Berkeley, CA (MH); Department of Medicine, University of California at San Francisco, San Francisco, CA (MH); Center for Regulatory and Environmental Analytical Metabolomics, Department of Chemistry, University of Louisville, Louisville, KY (PL); Graduate Center of Toxicology, Biopharm Complex, University of Kentucky, Lexington, KY (ANL, TW-MF); University of Colorado Comprehensive Cancer Center, Denver, CO (DT). Present affiliations: Department of Biomedical Informatics, Windber Research Institute, Windber, PA (YR); Mathematics and Computer Science Department, Eastern Connecticut State University, Willimantic, CT (GD).

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http://dx.doi.org/10.1093/jnci/dju062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580555PMC
April 2014

Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer.

Cancer Cell 2013 Mar 28;23(3):316-31. Epub 2013 Feb 28.

Department of Molecular and Cellular Biochemistry, The University of Kentucky, College of Medicine, Lexington, KY 40506, USA.

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http://dx.doi.org/10.1016/j.ccr.2013.01.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703516PMC
March 2013

A Carbonyl Capture Approach for Profiling Oxidized Metabolites in Cell Extracts.

Metabolomics 2012 19;8(6):989-996. Epub 2012 Jan 19.

Department of Chemistry and Center for Regulatory and Environmental Analytical Metabolomics (CREAM), University of Louisville, Louisville, KY, 40292, USA.

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http://dx.doi.org/10.1007/s11306-011-0395-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501132PMC
January 2012

High information throughput analysis of nucleotides and their isotopically enriched isotopologues by direct-infusion FTICR-MS.

Metabolomics 2012 9;8(5):930-939. Epub 2011 Dec 9.

Department of Chemistry, University of Louisville, 2210 S. Brook St, Rm 348 John W. Shumaker Research Building, Louisville, KY 40292, USA.

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http://dx.doi.org/10.1007/s11306-011-0388-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477816PMC
December 2011

Stable Isotope Resolved Metabolomics Analysis of Ribonucleotide and RNA Metabolism in Human Lung Cancer Cells.

Metabolomics 2012 Jun;8(3):517-527

Department of Chemistry, University of Louisville, 2210 S. Brook St, Rm 348 John W. Shumaker Research, Building, Louisville, KY 40292, USA ; Center for Regulatory Environmental Analytical Metabolomics, 2210 S. Brook St., Louisville, KY 40292, USA ; JG Brown Cancer Center, Clinical Translational Research Building, 505 S. Hancock St., Louisville, KY 40202, USA ; Department of Medicine, Clinical Translational Research Building, 505 S. Hancock St., Louisville, KY 40202, USA.

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http://link.springer.com/10.1007/s11306-011-0337-9
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http://dx.doi.org/10.1007/s11306-011-0337-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486296PMC
June 2012

Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC.

Proc Natl Acad Sci U S A 2012 Jun 21;109(23):8983-8. Epub 2012 May 21.

Metabolism and Cancer Susceptibility Section, Basic Research Laboratory, National Cancer Institute, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1073/pnas.1203244109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384197PMC
June 2012

Stable isotope resolved metabolomics of lung cancer in a SCID mouse model.

Metabolomics 2011 Jun;7(2):257-269

Department of Chemistry, University of Louisville, 2210 S. Brook St, Rm 348 John W. Shumaker Research Building, Louisville, KY 40292, USA.

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http://dx.doi.org/10.1007/s11306-010-0249-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109995PMC
June 2011

A novel deconvolution method for modeling UDP-N-acetyl-D-glucosamine biosynthetic pathways based on (13)C mass isotopologue profiles under non-steady-state conditions.

BMC Biol 2011 May 31;9:37. Epub 2011 May 31.

Department of Chemistry and Center for Regulatory & Environmental Analytical Metabolomics (CREAM), University of Louisville, Louisville, KY 40292, USA.

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http://dx.doi.org/10.1186/1741-7007-9-37DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3126751PMC
May 2011

NMR-based stable isotope resolved metabolomics in systems biochemistry.

J Biomol NMR 2011 Apr 26;49(3-4):267-80. Epub 2011 Feb 26.

Department of Chemistry, University of Louisville, Louisville, KY, USA.

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http://dx.doi.org/10.1007/s10858-011-9484-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087304PMC
April 2011

Stable isotope-resolved metabolomics (SIRM) in cancer research with clinical application to nonsmall cell lung cancer.

OMICS 2011 Mar 17;15(3):173-82. Epub 2011 Feb 17.

JG Brown Cancer Center, Department of Chemistry, University of Louisville, Louisville, Kentucky 40202, USA.

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http://dx.doi.org/10.1089/omi.2010.0088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125551PMC
March 2011

Edelfosine-induced metabolic changes in cancer cells that precede the overproduction of reactive oxygen species and apoptosis.

BMC Syst Biol 2010 Oct 6;4:135. Epub 2010 Oct 6.

Department of Biochemistry and Molecular Biology, Faculty of Biology, Institute of Biomedicine of University of Barcelona (IBUB) and IDIBAPS, Unit Associated with CSIC, Barcelona, Spain.

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http://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0
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http://dx.doi.org/10.1186/1752-0509-4-135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2984393PMC
October 2010

Isotopomer analysis of lipid biosynthesis by high resolution mass spectrometry and NMR.

Anal Chim Acta 2009 Oct 27;651(2):201-8. Epub 2009 Aug 27.

JG Brown Cancer Center, 529 S. Jackson Street, Louisville, KY 40202, USA.

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http://dx.doi.org/10.1016/j.aca.2009.08.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757635PMC
October 2009

Metabolic profiling identifies lung tumor responsiveness to erlotinib.

Exp Mol Pathol 2009 Aug 3;87(1):83-6. Epub 2009 May 3.

Department of Chemistry University of Louisville, Louisville, KY 40208, USA.

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http://dx.doi.org/10.1016/j.yexmp.2009.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729693PMC
August 2009

Stable isotope-assisted metabolomics in cancer research.

IUBMB Life 2008 Feb;60(2):124-9

JG Brown Cancer Center, Louisville, KY 40202, USA.

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http://dx.doi.org/10.1002/iub.17DOI Listing
February 2008

Sensitivity to sodium arsenite in human melanoma cells depends upon susceptibility to arsenite-induced mitotic arrest.

Toxicol Appl Pharmacol 2008 Jun 5;229(2):252-61. Epub 2008 Feb 5.

Department of Pharmacology and Toxicology, University of Louisville, 570 S. Preston Street, Suite 221, Louisville, KY 40202, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S0041008X0800044
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http://dx.doi.org/10.1016/j.taap.2008.01.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2474465PMC
June 2008

Isotopomer-based metabolomic analysis by NMR and mass spectrometry.

Methods Cell Biol 2008 ;84:541-88

JG Brown Cancer Center, University of Louisville, Louisville, Kentucky 40202, USA.

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http://dx.doi.org/10.1016/S0091-679X(07)84018-0DOI Listing
December 2007

Extreme anoxia tolerance in embryos of the annual killifish Austrofundulus limnaeus: insights from a metabolomics analysis.

J Exp Biol 2007 Jul;210(Pt 13):2253-66

Department of Biology, Portland State University, PO Box 751, Portland, OR 97207-0751, USA.

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http://dx.doi.org/10.1242/jeb.005116DOI Listing
July 2007

Integrating metabolomics and transcriptomics for probing SE anticancer mechanisms.

Drug Metab Rev 2006 ;38(4):707-32

James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky 40202, USA.

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http://dx.doi.org/10.1080/03602530600959599DOI Listing
January 2007

The promise of metabolomics in cancer molecular therapeutics.

Curr Opin Mol Ther 2004 Dec;6(6):584-92

University of Louisville, Department of Chemistry, Louisville, KY 40208, USA.

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December 2004

Chronic effects of dietary selenium on juvenile Sacramento splittail (Pogonichthys macrolepidotus).

Environ Sci Technol 2004 Nov;38(22):6085-93

Aquatic Toxicology Program, Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California, Davis, California 95616, USA.

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http://dx.doi.org/10.1021/es049545+DOI Listing
November 2004

An electrophoretic profiling method for thiol-rich phytochelatins and metallothioneins.

Phytochem Anal 2004 May-Jun;15(3):175-83

Department of Land, Air and Water Resources, University of California, Davis, CA 95616, USA.

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http://dx.doi.org/10.1002/pca.765DOI Listing
August 2004

Secondary structure and stability of the selenocysteine insertion sequences (SECIS) for human thioredoxin reductase and glutathione peroxidase.

Nucleic Acids Res 2004 16;32(5):1746-55. Epub 2004 Mar 16.

Division of Molecular Structure, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.

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http://dx.doi.org/10.1093/nar/gkh331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC390329PMC
July 2004

Selenium biotransformations into proteinaceous forms by foodweb organisms of selenium-laden drainage waters in California.

Aquat Toxicol 2002 Apr;57(1-2):65-84

Department of Land, Air and Water Resources, University of California, Davis, CA 95616, USA.

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http://dx.doi.org/10.1016/s0166-445x(01)00261-2DOI Listing
April 2002