Teresa A. Murray, PhD - Louisiana Tech University - Associate Professor

Teresa A. Murray

PhD

Louisiana Tech University

Associate Professor

Ruston, LA | United States

Main Specialties: Neurology, Other

Additional Specialties: Brain injury and epilepsy research

ORCID logohttps://orcid.org/0000-0002-8857-154X


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Teresa A. Murray, PhD - Louisiana Tech University - Associate Professor

Teresa A. Murray

PhD

Introduction

Dr. Murray is a creative neuroscientist and engineer with a passion for brain research. She is a BRAIN Initiative researcher.
While completing a postdoctoral fellowship at Yale, she pioneered the development of implanted, singlet gradient index (GRIN) lenses for acute deep brain imaging in mice. After establishing her own lab, she developed and optimized minimally invasive GRIN lens systems and imaging support platforms. She employs these systems to conduct longitudinal studies using rodent models of brain injury and disease and to evaluate the effects of potential therapeutic compounds and nanoparticle delivery systems. She also develops animal, tissue, and cell culture models for cell and network level collaborative research and consults on designs for next generation, real-time, neurochemical microbiosensors for brain research. Teresa is experienced in electrophysiology, neurotransmitter dynamics, genetic engineering, and molecular biology. Her microscopy expertise includes, FRET, TIRF, and spectral confocal microscopy, and multiphoton microscopy, including label-free imaging. She also has expertise in animal behavioral studies.
Dr. Murray also has expertise in marketing for start-up companies and experience in sales and national accounts customer support including Fortune 500 companies. She is an experienced international traveler and collaborator.

Primary Affiliation: Louisiana Tech University - Ruston, LA , United States

Specialties:

Additional Specialties:

Research Interests:


View Teresa A. Murray’s Resume / CV

Education

Oct 2009
Arizona State University
PhD
Bioengineering [Neuroscience]
Oct 2002
Arizona State University
BS
Bioengineering

Experience

Sep 2016
Co-principal investigator ($6M USD NSF grant, L Iasemidis, PI)
Thrust area lead investigator
Neurochemical and electrophysiological recordings in rats to study epileptogenesis
Sep 2015
Principal investigator
Lead project
Develop use minimally invasive, high resolution, deep brain imaging method that my lab developed to evaluate drugs in mouse models of TBI and stroke
Aug 2012
Principal Investigator
Lead project
Develop high resolution, minimally invasive, deep brain imaging system for rodent models of disesae and injury

Publications

15Publications

167Reads

68Profile Views

Effect of process parameters on electrochemical performance of a glutamate microbiosensor

J Electrochem. Soc. 2020 Jan 29;167[2]:027528

Journal of the Electrochemical Society

Article available at  https://iopscience.iop.org/article/10.1149/1945-7111/ab6b0b.Abstract         The effect of process parameters on the electrochemical performance of a glutamate (Glu) microbiosensor was studied. Glu is a major excitatory neurochemical that is essential for regulation of several brain functions. Glu dysregulation is associated with several neuropathological conditions such as epilepsy, Parkinson's and Alzheimer's disease. Here, an enzymatic microbiosensor in the form of a ceramic-shank substrate enabled platinum (Pt) microelectrode array (MEA) was employed to investigate the effect of key process parameters such as MEA surface cleaning methods, the effects of GluOx concentration, GluOx loading and size-exclusion layer thicknesses on Glu sensitivity and selectivity towards common interferents. A two-step cleaning procedure demonstrated a 57.4% increase in hydrogen peroxide sensitivity, which is due to 80-fold and 2-fold reductions respectively in the charge transfer resistances of the Pt microelectrode grains and grain boundaries. The microbiosensor demonstrated an excellent combination of sensitivity (530 ± 34 nA cm−2 μM−1), selectivity (841 ± 54) and long-term stability (2 months). These results provide a detailed account of changes in electrochemical properties and sensitivities of Pt microelectrodes toward peroxide, the rationale for choosing a higher GluOx concentration (0.4 U/μl) instead of 0.1 U/μl, which is the most commonly used concentration in the literature and recommendations on the enzyme loading and placement of size-exclusion coatings and their deposition conditions, which significantly affects the biosensor performance.

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January 2020

Self-Assembled Metal-Organic Biohybrids (MOBs) Using Copper and Silver for Cell Studies.

Nanomaterials (Basel) 2019 Sep 8;9(9). Epub 2019 Sep 8.

Cellular Neuroscience Laboratory, Biomedical Engineering, College of Engineering and Sciences, Louisiana Tech University, Ruston, LA 71270, USA.

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http://dx.doi.org/10.3390/nano9091282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781094PMC
September 2019
2 Reads

PICS: a platform for planar imaging of curved surfaces of brain and other tissue.

Brain Struct Funct 2019 Jun 22;224(5):1947-1956. Epub 2019 Mar 22.

Center for Biomedical Engineering and Rehabilitation Sciences, Louisiana Tech University, PO Box 10157, Ruston, LA, 71272-0046, USA.

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http://dx.doi.org/10.1007/s00429-019-01861-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6565470PMC
June 2019
16 Reads
5.618 Impact Factor

Time course images of cellular injury and recovery in murine brain with high-resolution GRIN lens system.

Sci Rep 2019 05 28;9(1):7946. Epub 2019 May 28.

Center for Biomedical Engineering and Rehabilitation Sciences, Louisiana Tech University, Ruston, Louisiana, USA.

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http://dx.doi.org/10.1038/s41598-019-44174-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538613PMC
May 2019
5 Reads
5.078 Impact Factor

An enzyme-based electrochemical biosensor probe with sensitivity to detect astrocytic versus glioma uptake of glutamate in real time in vitro.

Biosens Bioelectron 2019 Feb 16;126:751-757. Epub 2018 Nov 16.

Biomedical Engineering, PO Box 10157, Ruston, LA 71272, USA; Center for Biomedical Engineering and Rehabilitation Sciences, Louisiana Tech University, PO Box 10157, Ruston, LA 71272, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bios.2018.11.023DOI Listing
February 2019
3 Reads
6.409 Impact Factor

A Novel Microbiosensor Microarray for Continuous Monitoring of Gamma-Aminobutyric Acid in Real-Time.

Front Neurosci 2018 7;12:500. Epub 2018 Aug 7.

Institute for Micromanufacturing, Louisiana Tech University, Ruston, LA, United States.

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http://dx.doi.org/10.3389/fnins.2018.00500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090213PMC
August 2018
8 Reads

From solvent-free microspheres to bioactive gradient scaffolds.

Nanomedicine 2017 04 26;13(3):1157-1169. Epub 2016 Oct 26.

Marquette University School of Dentistry, Milwaukee, WI, USA; Helmerich Advanced Technology Research Center, Oklahoma State University, Tulsa, OK, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nano.2016.10.008DOI Listing
April 2017
29 Reads
6.155 Impact Factor

MATSAP: An automated analysis of stretch-attend posture in rodent behavioral experiments.

Sci Rep 2016 08 9;6:31286. Epub 2016 Aug 9.

Department of Biomedical Engineering, Louisiana Tech University, Ruston, Louisiana, United States of America.

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http://dx.doi.org/10.1038/srep31286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977506PMC
August 2016
5.078 Impact Factor

Gradient Index Microlens Implanted in Prefrontal Cortex of Mouse Does Not Affect Behavioral Test Performance over Time.

PLoS One 2016 22;11(1):e0146533. Epub 2016 Jan 22.

Center for Biomedical Research and Rehabilitation Sciences, Louisiana Tech University, Ruston, Louisiana, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0146533PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4723314PMC
July 2016
7 Reads
3.234 Impact Factor

TRIO Platform: A Novel Low Profile In vivo Imaging Support and Restraint System for Mice.

Front Neurosci 2016 25;10:169. Epub 2016 Apr 25.

Integrated Neuroscience and Imaging Lab, Center for Biomedical Engineering and Rehabilitation Sciences, Louisiana Tech University Ruston, LA, USA.

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http://dx.doi.org/10.3389/fnins.2016.00169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4842766PMC
May 2016
2 Reads

Multiphoton microscopy of cleared mouse brain expressing YFP.

J Vis Exp 2012 Sep 23(67):e3848. Epub 2012 Sep 23.

Department of Biomedical Engineering, Yale University, CT, USA.

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http://dx.doi.org/10.3791/3848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3490273PMC
September 2012
7 Reads

Singlet gradient index lens for deep in vivo multiphoton microscopy.

J Biomed Opt 2012 Feb;17(2):021106

Yale University, Department of Biomedical Engineering, New Haven, Connecticut 06511, USA.

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http://dx.doi.org/10.1117/1.JBO.17.2.021106DOI Listing
February 2012
3 Reads
2.859 Impact Factor

Nicotinic acetylcholine receptor alpha7 subunits with a C2 cytoplasmic loop yellow fluorescent protein insertion form functional receptors.

Acta Pharmacol Sin 2009 Jun;30(6):828-41

Barrow Neurological Institute, St Joseph's Hospital and Medical Center, 350 W Thomas Road, Phoenix, AZ 85013, USA.

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http://dx.doi.org/10.1038/aps.2009.78DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002364PMC
June 2009
2 Reads
2.496 Impact Factor

Role of alpha7-nicotinic acetylcholine receptors in tetanic stimulation-induced gamma oscillations in rat hippocampal slices.

Neuropharmacology 2005 May;48(6):869-80

Division of Neurology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ 85013-4496, USA.

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http://dx.doi.org/10.1016/j.neuropharm.2005.01.003DOI Listing
May 2005
16 Reads
5.106 Impact Factor

Top co-authors

Jie Wu
Jie Wu

Fudan University

3
Benjamin S Kemp
Benjamin S Kemp

Integrated Neuroscience and Imaging Lab

3
Ronald J Lukas
Ronald J Lukas

Barrow Neurological Institute

3
Vladislav Voziyanov
Vladislav Voziyanov

Integrated Neuroscience and Imaging Lab

2
Prabhu U Arumugam
Prabhu U Arumugam

University of Arkansas

2
Qiang Liu
Qiang Liu

Research Center of Brain and Cognitive Neuroscience

2
Paul Whiteaker
Paul Whiteaker

Institute for Behavioral Genetics

2
Shabnam Siddiqui
Shabnam Siddiqui

Advanced Diamond Technologies

2
Michael J Levene
Michael J Levene

Yale University

2
Kevin S Holly
Kevin S Holly

Center for Biomedical Research and Rehabilitation Sciences

2