Temitope Keku

Temitope Keku

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Temitope Keku

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Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis.

Nat Commun 2020 Jan 30;11(1):597. Epub 2020 Jan 30.

Section of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France.

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http://dx.doi.org/10.1038/s41467-020-14389-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992637PMC
January 2020

Cumulative Burden of Colorectal Cancer-Associated Genetic Variants is More Strongly Associated With Early-onset vs Late-onset Cancer.

Authors:
Alexi N Archambault Yu-Ru Su Jihyoun Jeon Minta Thomas Yi Lin David V Conti Aung Ko Win Lori C Sakoda Iris Lansdorp-Vogelaar Elisabeth Fp Peterse Ann G Zauber David Duggan Andreana N Holowatyj Jeroen R Huyghe Hermann Brenner Michelle Cotterchio Stéphane Bézieau Stephanie L Schmit Christopher K Edlund Melissa C Southey Robert J MacInnis Peter T Campbell Jenny Chang-Claude Martha L Slattery Andrew T Chan Amit D Joshi Mingyang Song Yin Cao Michael O Woods Emily White Stephanie J Weinstein Cornelia M Ulrich Michael Hoffmeister Stephanie A Bien Tabitha A Harrison Jochen Hampe Christopher I Li Clemens Schafmayer Kenneth Offit Paul D Pharoah Victor Moreno Annika Lindblom Alicja Wolk Anna H Wu Li Li Marc J Gunter Andrea Gsur Temitope O Keku Rachel Pearlman D Timothy Bishop Sergi Castellví-Bel Leticia Moreira Pavel Vodicka Ellen Kampman Graham G Giles Demetrius Albanes John A Baron Sonja I Berndt Stefanie Brezina Stephan Buch Daniel D Buchanan Antonia Trichopoulou Gianluca Severi María-Dolores Chirlaque Maria-José Sánchez Domenico Palli Tilman Kühn Neil Murphy Amanda J Cross Andrea N Burnett-Hartman Stephen J Chanock Albert de la Chapelle Douglas F Easton Faye Elliott Dallas R English Edith Jm Feskens Liesel M FitzGerald Phyllis J Goodman John L Hopper Thomas J Hudson David J Hunter Eric J Jacobs Corinne E Joshu Sébastien Küry Sanford D Markowitz Roger L Milne Elizabeth A Platz Gad Rennert Hedy S Rennert Fredrick R Schumacher Robert S Sandler Daniela Seminara Catherine M Tangen Stephen N Thibodeau Amanda E Toland Franzel Jb van Duijnhoven Kala Visvanathan Ludmila Vodickova John D Potter Satu Männistö Korbinian Weigl Jane Figueiredo Vicente Martín Susanna C Larsson Patrick S Parfrey Wen-Yi Huang Heinz-Josef Lenz Jose E Castelao Manuela Gago-Dominguez Victor Muñoz-Garzón Christoph Mancao Christopher A Haiman Lynne R Wilkens Erin Siegel Elizabeth Barry Ban Younghusband Bethany Van Guelpen Sophia Harlid Anne Zeleniuch-Jacquotte Peter S Liang Mengmeng Du Graham Casey Noralane M Lindor Loic Le Marchand Steven J Gallinger Mark A Jenkins Polly A Newcomb Stephen B Gruber Robert E Schoen Heather Hampel Douglas A Corley Li Hsu Ulrike Peters Richard B Hayes

Gastroenterology 2019 Dec 19. Epub 2019 Dec 19.

Division of Epidemiology, Department of Population Health, New York University School of Medicine, New York, New York, USA.

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http://dx.doi.org/10.1053/j.gastro.2019.12.012DOI Listing
December 2019

Circulating Levels of Insulin-like Growth Factor 1 and Insulin-like Growth Factor Binding Protein 3 Associate With Risk of Colorectal Cancer Based on Serologic and Mendelian Randomization Analyses.

Gastroenterology 2019 Dec 26. Epub 2019 Dec 26.

Section of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France.

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http://dx.doi.org/10.1053/j.gastro.2019.12.020DOI Listing
December 2019

Sex and Race Disparities in Diverticulosis Prevalence.

Clin Gastroenterol Hepatol 2019 Oct 18. Epub 2019 Oct 18.

University of North Carolina, School of Medicine, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1016/j.cgh.2019.10.022DOI Listing
October 2019

Evaluation of vitamin D biosynthesis and pathway target genes reveals UGT2A1/2 and EGFR polymorphisms associated with epithelial ovarian cancer in African American Women.

Cancer Med 2019 05 18;8(5):2503-2513. Epub 2019 Apr 18.

Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cam4.1996
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http://dx.doi.org/10.1002/cam4.1996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6536963PMC
May 2019

Discovery of common and rare genetic risk variants for colorectal cancer.

Authors:
Jeroen R Huyghe Stephanie A Bien Tabitha A Harrison Hyun Min Kang Sai Chen Stephanie L Schmit David V Conti Conghui Qu Jihyoun Jeon Christopher K Edlund Peyton Greenside Michael Wainberg Fredrick R Schumacher Joshua D Smith David M Levine Sarah C Nelson Nasa A Sinnott-Armstrong Demetrius Albanes M Henar Alonso Kristin Anderson Coral Arnau-Collell Volker Arndt Christina Bamia Barbara L Banbury John A Baron Sonja I Berndt Stéphane Bézieau D Timothy Bishop Juergen Boehm Heiner Boeing Hermann Brenner Stefanie Brezina Stephan Buch Daniel D Buchanan Andrea Burnett-Hartman Katja Butterbach Bette J Caan Peter T Campbell Christopher S Carlson Sergi Castellví-Bel Andrew T Chan Jenny Chang-Claude Stephen J Chanock Maria-Dolores Chirlaque Sang Hee Cho Charles M Connolly Amanda J Cross Katarina Cuk Keith R Curtis Albert de la Chapelle Kimberly F Doheny David Duggan Douglas F Easton Sjoerd G Elias Faye Elliott Dallas R English Edith J M Feskens Jane C Figueiredo Rocky Fischer Liesel M FitzGerald David Forman Manish Gala Steven Gallinger W James Gauderman Graham G Giles Elizabeth Gillanders Jian Gong Phyllis J Goodman William M Grady John S Grove Andrea Gsur Marc J Gunter Robert W Haile Jochen Hampe Heather Hampel Sophia Harlid Richard B Hayes Philipp Hofer Michael Hoffmeister John L Hopper Wan-Ling Hsu Wen-Yi Huang Thomas J Hudson David J Hunter Gemma Ibañez-Sanz Gregory E Idos Roxann Ingersoll Rebecca D Jackson Eric J Jacobs Mark A Jenkins Amit D Joshi Corinne E Joshu Temitope O Keku Timothy J Key Hyeong Rok Kim Emiko Kobayashi Laurence N Kolonel Charles Kooperberg Tilman Kühn Sébastien Küry Sun-Seog Kweon Susanna C Larsson Cecelia A Laurie Loic Le Marchand Suzanne M Leal Soo Chin Lee Flavio Lejbkowicz Mathieu Lemire Christopher I Li Li Li Wolfgang Lieb Yi Lin Annika Lindblom Noralane M Lindor Hua Ling Tin L Louie Satu Männistö Sanford D Markowitz Vicente Martín Giovanna Masala Caroline E McNeil Marilena Melas Roger L Milne Lorena Moreno Neil Murphy Robin Myte Alessio Naccarati Polly A Newcomb Kenneth Offit Shuji Ogino N Charlotte Onland-Moret Barbara Pardini Patrick S Parfrey Rachel Pearlman Vittorio Perduca Paul D P Pharoah Mila Pinchev Elizabeth A Platz Ross L Prentice Elizabeth Pugh Leon Raskin Gad Rennert Hedy S Rennert Elio Riboli Miguel Rodríguez-Barranco Jane Romm Lori C Sakoda Clemens Schafmayer Robert E Schoen Daniela Seminara Mitul Shah Tameka Shelford Min-Ho Shin Katerina Shulman Sabina Sieri Martha L Slattery Melissa C Southey Zsofia K Stadler Christa Stegmaier Yu-Ru Su Catherine M Tangen Stephen N Thibodeau Duncan C Thomas Sushma S Thomas Amanda E Toland Antonia Trichopoulou Cornelia M Ulrich David J Van Den Berg Franzel J B van Duijnhoven Bethany Van Guelpen Henk van Kranen Joseph Vijai Kala Visvanathan Pavel Vodicka Ludmila Vodickova Veronika Vymetalkova Korbinian Weigl Stephanie J Weinstein Emily White Aung Ko Win C Roland Wolf Alicja Wolk Michael O Woods Anna H Wu Syed H Zaidi Brent W Zanke Qing Zhang Wei Zheng Peter C Scacheri John D Potter Michael C Bassik Anshul Kundaje Graham Casey Victor Moreno Goncalo R Abecasis Deborah A Nickerson Stephen B Gruber Li Hsu Ulrike Peters

Nat Genet 2019 01 3;51(1):76-87. Epub 2018 Dec 3.

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

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http://www.nature.com/articles/s41588-018-0286-6
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http://dx.doi.org/10.1038/s41588-018-0286-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358437PMC
January 2019

Colonic Diverticula Are Not Associated With Mucosal Inflammation or Chronic Gastrointestinal Symptoms.

Clin Gastroenterol Hepatol 2018 06 8;16(6):884-891.e1. Epub 2017 Jun 8.

Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1016/j.cgh.2017.05.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722710PMC
June 2018

Lifestyle Factors, Colorectal Tumor Methylation, and Survival Among African Americans and European Americans.

Sci Rep 2018 06 21;8(1):9470. Epub 2018 Jun 21.

Department of Medicine, University of North Carolina, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1038/s41598-018-27738-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013500PMC
June 2018

An Aberrant Microbiota is not Strongly Associated with Incidental Colonic Diverticulosis.

Sci Rep 2018 03 21;8(1):4951. Epub 2018 Mar 21.

Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1038/s41598-018-23023-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862835PMC
March 2018

Maternal Gut Microbiome Biodiversity in Pregnancy.

Am J Perinatol 2018 01 27;35(1):24-30. Epub 2017 Jul 27.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1055/s-0037-1604412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102712PMC
January 2018

Haploinsufficiency of SIRT1 Enhances Glutamine Metabolism and Promotes Cancer Development.

Curr Biol 2017 Feb 2;27(4):483-494. Epub 2017 Feb 2.

Signal Transduction Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2016.12.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319916PMC
February 2017

Gut microbiome compositional and functional differences between tumor and non-tumor adjacent tissues from cohorts from the US and Spain.

Gut Microbes 2015 ;6(3):161-72

a Department of Cell Biology and Physiology, and Microbiome Core Facility; University of North Carolina School of Medicine ; Chapel Hill , NC , USA.

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http://dx.doi.org/10.1080/19490976.2015.1039223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615176PMC
February 2016

Evaluating markers of epithelial-mesenchymal transition to identify cancer patients at risk for metastatic disease.

Clin Exp Metastasis 2016 Jan 27;33(1):53-62. Epub 2015 Oct 27.

Department of Epidemiology, University of North Carolina at Chapel Hill, McGavran-Greenberg Hall, CB #7435, Chapel Hill, NC, 27599, USA.

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http://dx.doi.org/10.1007/s10585-015-9757-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742430PMC
January 2016

Gut microbiome and colorectal adenomas.

Cancer J 2014 May-Jun;20(3):225-31

From the *Center for Gastrointestinal Biology and Disease, and Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina at Chapel Hill, and †School of Medicine, University of North Carolina at Chapel Hill, NC.

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http://pdfs.journals.lww.com/journalppo/2014/05000/Gut_Micro
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/PPO.0000000000000050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589167PMC
March 2015

The gastrointestinal microbiota and colorectal cancer.

Am J Physiol Gastrointest Liver Physiol 2015 Mar 24;308(5):G351-63. Epub 2014 Dec 24.

Surveillance and Health Services Research, American Cancer Society, Atlanta, Georgia.

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http://dx.doi.org/10.1152/ajpgi.00360.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346754PMC
March 2015

Reduced insulin-like growth factor I receptor and altered insulin receptor isoform mRNAs in normal mucosa predict colorectal adenoma risk.

Cancer Epidemiol Biomarkers Prev 2014 Oct 13;23(10):2093-100. Epub 2014 Jul 13.

Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1158/1055-9965.EPI-14-0177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201381PMC
October 2014

Somatic gene mutations in African Americans may predict worse outcomes in colorectal cancer.

Cancer Biomark 2013 ;13(5):359-66

Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC, USA.

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http://dx.doi.org/10.3233/CBM-130366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589188PMC
September 2014

Genetic variation in vitamin D-related genes and risk of colorectal cancer in African Americans.

Cancer Causes Control 2014 May 23;25(5):561-70. Epub 2014 Feb 23.

Department of Pediatrics and the Institute of Human Genetics, University of Illinois at Chicago, 900 S. Ashland Ave. MC 767, Chicago, IL, 60607, USA.

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http://dx.doi.org/10.1007/s10552-014-0361-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978221PMC
May 2014

Altered tissue metabolites correlate with microbial dysbiosis in colorectal adenomas.

J Proteome Res 2014 Apr 21;13(4):1921-9. Epub 2014 Mar 21.

School of Medicine, University of North Carolina at Chapel Hill , 321 South Columbia Street, Chapel Hill, North Carolina 27599, United States.

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http://dx.doi.org/10.1021/pr4009783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993967PMC
April 2014

Nucleotide excision repair gene polymorphisms, meat intake and colon cancer risk.

Mutat Res 2014 Apr 7;762:24-31. Epub 2014 Mar 7.

Sylvester Comprehensive Cancer Center and Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL, 33136, USA. Electronic address:

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http://dx.doi.org/10.1016/j.mrfmmm.2014.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056032PMC
April 2014

Fusobacterium spp. and colorectal cancer: cause or consequence?

Trends Microbiol 2013 Oct 9;21(10):506-8. Epub 2013 Sep 9.

Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address:

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http://www.cell.com/trends/microbiology/pdf/S0966-842X(13)00
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http://dx.doi.org/10.1016/j.tim.2013.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836616PMC
October 2013

Fusobacterium is associated with colorectal adenomas.

PLoS One 2013 15;8(1):e53653. Epub 2013 Jan 15.

Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0053653PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546075PMC
June 2013

Differences in microbial signatures between rectal mucosal biopsies and rectal swabs.

Gut Microbes 2012 Nov-Dec;3(6):530-5. Epub 2012 Oct 11.

Division of Gastroenterology and Hepatology, Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.4161/gmic.22157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495790PMC
April 2013

Plasma insulin, glucose, IGF-I, IGF-II, and IGFBP-3 and risk of recurrent colorectal adenomas.

J Gastroenterol Hepatol Res 2013 Apr;2(4):531-535

Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC.

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http://dx.doi.org/10.6051/j.issn.2224-3992.2013.02.247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3922127PMC
April 2013

Association of plasma endotoxin, inflammatory cytokines and risk of colorectal adenomas.

BMC Cancer 2013 Feb 26;13:91. Epub 2013 Feb 26.

Center for Gastrointestinal Biology and Disease, University of North Carolina, 103 Mason Farm Road, 7340 Medical Biomolecular Research Building, CB # 7032, 27599-7032, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1186/1471-2407-13-91DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599094PMC
February 2013

Association of eleven common, low-penetrance colorectal cancer susceptibility genetic variants at six risk loci with clinical outcome.

PLoS One 2012 27;7(7):e41954. Epub 2012 Jul 27.

Division of Pharmacotherapy and Experimental Therapeutics, Institute for Pharmacogenomics and Individualized Therapy, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0041954PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407042PMC
January 2013

Elevated C-peptide and insulin predict increased risk of colorectal adenomas in normal mucosa.

BMC Cancer 2012 Sep 5;12:389. Epub 2012 Sep 5.

Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, North Carolina, USA.

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http://dx.doi.org/10.1186/1471-2407-12-389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489909PMC
September 2012

Genetic variants in IGF-I, IGF-II, IGFBP-3, and adiponectin genes and colon cancer risk in African Americans and Whites.

Cancer Causes Control 2012 Jul 8;23(7):1127-38. Epub 2012 May 8.

Department of Medicine, Center for Gastrointestinal Biology and Disease, School of Medicine, University of North Carolina, Chapel Hill, 27599-7032, USA.

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http://dx.doi.org/10.1007/s10552-012-9981-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212518PMC
July 2012

Differential gene expression between African American and European American colorectal cancer patients.

PLoS One 2012 19;7(1):e30168. Epub 2012 Jan 19.

Department of Medicine/Gastroenterology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0030168PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261881PMC
June 2012

IGF2R genetic variants, circulating IGF2 concentrations and colon cancer risk in African Americans and Whites.

Dis Markers 2012 ;32(2):133-41

Department of Community and Family Medicine, and Program of Cancer Detection, Prevention and Control, Duke University Medical Center, NC, USA.

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http://dx.doi.org/10.3233/DMA-2011-0865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751395PMC
June 2012

Molecular analysis of the luminal- and mucosal-associated intestinal microbiota in diarrhea-predominant irritable bowel syndrome.

Am J Physiol Gastrointest Liver Physiol 2011 Nov 7;301(5):G799-807. Epub 2011 Jul 7.

Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, 27599-7080, USA.

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http://dx.doi.org/10.1152/ajpgi.00154.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220325PMC
November 2011

Molecular characterization of mucosal adherent bacteria and associations with colorectal adenomas.

Gut Microbes 2010 May-Jun;1(3):138-47. Epub 2010 May 13.

Center for Gastrointestinal Biology and Disease; University of North Carolina at Chapel Hill, NC, USA.

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http://dx.doi.org/10.4161/gmic.1.3.12360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927011PMC
September 2011

A germline variant in the TP53 polyadenylation signal confers cancer susceptibility.

Authors:
Simon N Stacey Patrick Sulem Aslaug Jonasdottir Gisli Masson Julius Gudmundsson Daniel F Gudbjartsson Olafur T Magnusson Sigurjon A Gudjonsson Bardur Sigurgeirsson Kristin Thorisdottir Rafn Ragnarsson Kristrun R Benediktsdottir Bjørn A Nexø Anne Tjønneland Kim Overvad Peter Rudnai Eugene Gurzau Kvetoslava Koppova Kari Hemminki Cristina Corredera Victoria Fuentelsaz Pilar Grasa Sebastian Navarrete Fernando Fuertes Maria D García-Prats Enrique Sanambrosio Angeles Panadero Ana De Juan Almudena Garcia Fernando Rivera Dolores Planelles Virtudes Soriano Celia Requena Katja K Aben Michelle M van Rossum Ruben G H M Cremers Inge M van Oort Dick-Johan van Spronsen Jack A Schalken Wilbert H M Peters Brian T Helfand Jenny L Donovan Freddie C Hamdy Daniel Badescu Ovidiu Codreanu Mariana Jinga Irma E Csiki Vali Constantinescu Paula Badea Ioan N Mates Daniela E Dinu Adrian Constantin Dana Mates Sjofn Kristjansdottir Bjarni A Agnarsson Eirikur Jonsson Rosa B Barkardottir Gudmundur V Einarsson Fridbjorn Sigurdsson Pall H Moller Tryggvi Stefansson Trausti Valdimarsson Oskar T Johannsson Helgi Sigurdsson Thorvaldur Jonsson Jon G Jonasson Laufey Tryggvadottir Terri Rice Helen M Hansen Yuanyuan Xiao Daniel H Lachance Brian Patrick O Neill Matthew L Kosel Paul A Decker Gudmar Thorleifsson Hrefna Johannsdottir Hafdis T Helgadottir Asgeir Sigurdsson Valgerdur Steinthorsdottir Annika Lindblom Robert S Sandler Temitope O Keku Karina Banasik Torben Jørgensen Daniel R Witte Torben Hansen Oluf Pedersen Viorel Jinga David E Neal William J Catalona Margaret Wrensch John Wiencke Robert B Jenkins Eduardo Nagore Ulla Vogel Lambertus A Kiemeney Rajiv Kumar José I Mayordomo Jon H Olafsson Augustine Kong Unnur Thorsteinsdottir Thorunn Rafnar Kari Stefansson

Nat Genet 2011 Sep 25;43(11):1098-103. Epub 2011 Sep 25.

deCODE genetics, Reykjavik, Iceland.

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http://dx.doi.org/10.1038/ng.926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263694PMC
September 2011

Gut microbial diversity is reduced by the probiotic VSL#3 and correlates with decreased TNBS-induced colitis.

Inflamm Bowel Dis 2011 Jan;17(1):289-97

Department of Medicine, Division of Gastroenterology and Hepatology and Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1002/ibd.21366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2953593PMC
January 2011

Genetic heterogeneity in colorectal cancer associations between African and European americans.

Gastroenterology 2010 Nov 24;139(5):1677-85, 1685.e1-8. Epub 2010 Jul 24.

Department of Medicine, Section of Gastroenterology, University of Chicago Medical Center, Chicago, Illinois 60637, USA.

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http://dx.doi.org/10.1053/j.gastro.2010.07.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3721963PMC
November 2010

Associations of red meat, fat, and protein intake with distal colorectal cancer risk.

Nutr Cancer 2010 ;62(6):701-9

Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, 135 Dauer Drive, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1080/01635581003605938DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023148PMC
November 2010

Antioxidant and DNA methylation-related nutrients and risk of distal colorectal cancer.

Cancer Causes Control 2010 Aug 30;21(8):1171-81. Epub 2010 Mar 30.

Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, McGavran-Greenberg Hall, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1007/s10552-010-9544-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3024035PMC
August 2010

Suppressor of cytokine signaling 3 (SOCS3) is not an independent biomarker of colorectal adenoma risk.

BMC Res Notes 2010 May 25;3:144. Epub 2010 May 25.

Department of Medicine and Center for Gastrointestinal Biology and Disease, University of North Carolina School of Medicine, 130 Mason Farm Road, Chapel Hill, North Carolina 27599-7545, USA.

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http://dx.doi.org/10.1186/1756-0500-3-144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883989PMC
May 2010

Polymorphisms in methionine synthase, methionine synthase reductase and serine hydroxymethyltransferase, folate and alcohol intake, and colon cancer risk.

J Nutrigenet Nutrigenomics 2008 2;1(4):196-204. Epub 2008 Jun 2.

Department of Nutrition, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, N.C., USA.

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https://www.karger.com/Article/FullText/136651
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http://dx.doi.org/10.1159/000136651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758622PMC
October 2009

Dietary patterns, food groups, and rectal cancer risk in Whites and African-Americans.

Cancer Epidemiol Biomarkers Prev 2009 May;18(5):1552-61

Department of Nutrition, University of North Carolina, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1158/1055-9965.EPI-08-1146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774490PMC
May 2009

KRAS/BRAF mutation status and ERK1/2 activation as biomarkers for MEK1/2 inhibitor therapy in colorectal cancer.

Mol Cancer Ther 2009 Apr;8(4):834-43

Department of Surgery, University of North Carolina at Chapel Hill, Lineberger Comprehensive Cancer Center, 450 West Drive, CB 7295, Chapel Hill, NC 27599-7295, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-08-0972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729756PMC
April 2009

Use of nonsteroidal antiinflammatory drugs and distal large bowel cancer in whites and African Americans.

Am J Epidemiol 2008 Dec 21;168(11):1292-300. Epub 2008 Oct 21.

Epidemiology Branch, National Institute of Environmental Health Sciences, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA.

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https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/
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http://dx.doi.org/10.1093/aje/kwn255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727267PMC
December 2008

Assessment of serum proteomics to detect large colon adenomas.

Cancer Epidemiol Biomarkers Prev 2008 Aug;17(8):2188-93

Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7080, USA.

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http://dx.doi.org/10.1158/1055-9965.EPI-07-2767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2561171PMC
August 2008

Local IGFBP-3 mRNA expression, apoptosis and risk of colorectal adenomas.

BMC Cancer 2008 May 22;8:143. Epub 2008 May 22.

Department of Medicine and Center for Gastrointestinal Biology & Disease, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1186/1471-2407-8-143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409350PMC
May 2008

Modification by N-acetyltransferase 1 genotype on the association between dietary heterocyclic amines and colon cancer in a multiethnic study.

Mutat Res 2008 Feb 13;638(1-2):162-74. Epub 2007 Oct 13.

University of California-Davis, Department of Public Health Sciences, Division of Epidemiology, Davis, CA 95616, USA.

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http://dx.doi.org/10.1016/j.mrfmmm.2007.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234436PMC
February 2008

Apoptosis in normal rectal mucosa, baseline adenoma characteristics, and risk of future adenomas.

Cancer Epidemiol Biomarkers Prev 2008 Feb;17(2):306-10

Department of Medicine and Center for Gastrointestinal Biology and Disease, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1158/1055-9965.EPI-07-0066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2636570PMC
February 2008

Circulating levels of inflammatory cytokines and risk of colorectal adenomas.

Cancer Res 2008 Jan;68(1):323-8

Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599-7555, USA.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-07-2924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2675825PMC
January 2008

RNA expression analysis of formalin-fixed paraffin-embedded tumors.

Lab Invest 2007 Apr 12;87(4):383-91. Epub 2007 Feb 12.

Department of Medicine, The University of North Carolina School of Medicine, Chapel Hill, NC 27599-7295, USA

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http://www.nature.com/articles/3700529
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http://dx.doi.org/10.1038/labinvest.3700529DOI Listing
April 2007

Calcium, dietary, and lifestyle factors in the prevention of colorectal adenomas.

Cancer 2007 Feb;109(3):510-7

Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.

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http://doi.wiley.com/10.1002/cncr.22453
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http://dx.doi.org/10.1002/cncr.22453DOI Listing
February 2007

Gastric cancer and the high combination prevalence of host cytokine genotypes and Helicobacter pylori in Honduras.

Clin Gastroenterol Hepatol 2006 Sep 3;4(9):1103-11. Epub 2006 Jul 3.

Department of Gastroenterology and Hepatology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1016/j.cgh.2006.05.025DOI Listing
September 2006

Polymorphisms in nucleotide excision repair genes, smoking and breast cancer in African Americans and whites: a population-based case-control study.

Carcinogenesis 2006 Jul 6;27(7):1377-85. Epub 2006 Jan 6.

Laboratory of Human Carcinogenesis, NCI/NIH, 37 Convent Drive MSC 4255, Bldg 37 Rm 3060, Bethesda, MD 20892-4255, USA.

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http://dx.doi.org/10.1093/carcin/bgi330DOI Listing
July 2006

Does physical activity modify the association between body mass index and colorectal adenomas?

Nutr Cancer 2005 ;51(2):140-5

Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill 27599, USA.

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http://dx.doi.org/10.1207/s15327914nc5102_3DOI Listing
October 2005

Polymorphisms in DNA repair genes, medical exposure to ionizing radiation, and breast cancer risk.

Cancer Epidemiol Biomarkers Prev 2005 Oct;14(10):2326-34

Department of Epidemiology, School of Public Health, University of North Carolina, CB 7400, Chapel Hill, NC 27599-7400, USA.

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http://dx.doi.org/10.1158/1055-9965.EPI-05-0186DOI Listing
October 2005

Insulin resistance, apoptosis, and colorectal adenoma risk.

Cancer Epidemiol Biomarkers Prev 2005 Sep;14(9):2076-81

Department of Medicine, University of North Carolina, Chapel Hill, 27599-7555, USA.

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http://dx.doi.org/10.1158/1055-9965.EPI-05-0239DOI Listing
September 2005

5,10-methylenetetrahydrofolate reductase 677 and 1298 polymorphisms, folate intake, and microsatellite instability in colon cancer.

Cancer Epidemiol Biomarkers Prev 2005 Aug;14(8):2023-9

Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7555, USA.

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http://dx.doi.org/10.1158/1055-9965.EPI-05-0131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540476PMC
August 2005

Diet, lifestyle, and genomic instability in the North Carolina Colon Cancer Study.

Cancer Epidemiol Biomarkers Prev 2005 Feb;14(2):429-36

Department of Global Epidemiology, Amgen, Inc., One Amgen Center Drive, 24-1-C, Thousand Oaks, CA 91320, USA.

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http://cebp.aacrjournals.org/cgi/doi/10.1158/1055-9965.EPI-0
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http://dx.doi.org/10.1158/1055-9965.EPI-04-0486DOI Listing
February 2005

Calcium, vitamin D, and apoptosis in the rectal epithelium.

Cancer Epidemiol Biomarkers Prev 2005 Feb;14(2):525-8

Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC 27599-7555, USA.

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http://dx.doi.org/10.1158/1055-9965.EPI-04-0466DOI Listing
February 2005

Manganese superoxide dismutase Ala-9Val polymorphism and risk of breast cancer in a population-based case-control study of African Americans and whites.

Breast Cancer Res 2004 7;6(4):R264-74. Epub 2004 Apr 7.

Department of Epidemiology, School of Public Health, and Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1186/bcr786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC468618PMC
November 2004

Loss of activin receptor type 2 protein expression in microsatellite unstable colon cancers.

Gastroenterology 2004 Mar;126(3):654-9

Departmentof Medicine, University of California, San Diego, USA.

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http://dx.doi.org/10.1053/j.gastro.2004.01.008DOI Listing
March 2004

Gene testing: what the health professional needs to know.

J Nutr 2003 11;133(11 Suppl 1):3754S-3757S

Center for Gastrointestinal Biology and Disease and Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1093/jn/133.11.3754SDOI Listing
November 2003

Vitamin C intake and apoptosis in normal rectal epithelium.

Cancer Epidemiol Biomarkers Prev 2003 Jun;12(6):559-65

Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7555, USA.

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June 2003

Family history of colon cancer: what does it mean and how is it useful?

Am J Prev Med 2003 Feb;24(2):170-6

Center for Gastrointestinal Biology and Disease, CB #7555, School of Medicine, University of North Carolina, Chapel Hill, NC 27599-7555, USA.

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http://dx.doi.org/10.1016/s0749-3797(02)00590-1DOI Listing
February 2003

Association between hemochromatosis (HFE) gene mutation carrier status and the risk of colon cancer.

J Natl Cancer Inst 2003 Jan;95(2):154-9

Center for Gastrointestinal Biology and Disease and Division of Digestive Diseases and Nutrition, University of North Carolina, Chapel Hill 27599-7080, USA.

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http://dx.doi.org/10.1093/jnci/95.2.154DOI Listing
January 2003

Nonsteroidal anti-inflammatory drugs, apoptosis, and colorectal adenomas.

Gastroenterology 2002 Dec;123(6):1770-7

Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, 27599, USA.

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http://dx.doi.org/10.1053/gast.2002.37053DOI Listing
December 2002

5,10-Methylenetetrahydrofolate reductase codon 677 and 1298 polymorphisms and colon cancer in African Americans and whites.

Cancer Epidemiol Biomarkers Prev 2002 Dec;11(12):1611-21

Center for Gastrointestinal Biology and Disease, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599-7555, USA.

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December 2002

Prostaglandin H synthase 2 variant (Val511Ala) in African Americans may reduce the risk for colorectal neoplasia.

Cancer Epidemiol Biomarkers Prev 2002 Nov;11(11):1305-15

Division of Medical Genetics, Department of Pediatrics, and the Research and Education Institute at Harbor-University of California, Los Angeles Medical Center, Torrance, California 90502, USA.

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November 2002

IGF-I and TGF-beta1 have distinct effects on phenotype and proliferation of intestinal fibroblasts.

Am J Physiol Gastrointest Liver Physiol 2002 Sep;283(3):G809-18

Department of Cell and Molecular Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7545, USA.

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http://dx.doi.org/10.1152/ajpgi.00057.2002DOI Listing
September 2002

Reduction of spontaneous and irradiation-induced apoptosis in small intestine of IGF-I transgenic mice.

Am J Physiol Gastrointest Liver Physiol 2002 Aug;283(2):G457-64

Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, 27599, USA.

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http://dx.doi.org/10.1152/ajpgi.00019.2002DOI Listing
August 2002