Dr. Tej K Pandita - The Houston Methodist Research Institute - Professor and Scientific Director

Dr. Tej K Pandita

The Houston Methodist Research Institute

Professor and Scientific Director

Houston, TX | United States

Main Specialties: Biology

Additional Specialties: Genetics

Dr. Tej K Pandita - The Houston Methodist Research Institute - Professor and Scientific Director

Dr. Tej K Pandita

Introduction

Dr. Pandita earned his Ph.D. from Panjab University in 1980. He held faculty appointments at Columbia University in New York, Washington University in St. Louis, Missouri, and The University of Texas Southwestern Medical Center in Dallas, Texas before becoming Scientific Director of the Radiation Oncology Department at the Houston Methodist Research Institute in 2014 where he directs a research program focusing on DNA repair and radiotherapy. He was elected a Fellow of the American Association for the Advancement of Science in 2013 and is the past Chairman of A-T Workshop 2012 (ATW2012) International meeting. He serves on multiple editorial boards and a chartered member of the NIH Study Sections. His research employs both genetic and biological approaches to study the relationships between DNA sequence, chromatin structure and sensitivity to ionizing radiation (IR). The long-term goal of his research program is to understand the mechanistic role of chromatin structure in regulating cell survival response to IR-induced DNA damage.

Primary Affiliation: The Houston Methodist Research Institute - Houston, TX , United States

Specialties:

Additional Specialties:

Research Interests:


View Dr. Tej K Pandita’s Resume / CV

Publications

108Publications

3237Reads

1Profile Views

2223PubMed Central Citations

Genetic and Pharmacological Targeting of Heat Shock Protein 70 in the Mouse Amygdala-Kindling Model.

ACS Chem Neurosci 2019 03 16;10(3):1434-1444. Epub 2018 Nov 16.

Institute of Pharmacology, Toxicology, and Pharmacy , Ludwig-Maximilians-University Munich , Koeniginstraße 16 , D-80539 Munich , Germany.

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http://pubs.acs.org/doi/10.1021/acschemneuro.8b00475
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http://dx.doi.org/10.1021/acschemneuro.8b00475DOI Listing
March 2019
17 Reads
4.362 Impact Factor

A homozygous FANCM frameshift pathogenic variant causes male infertility.

Genet Med 2019 01 12;21(1):62-70. Epub 2018 Jun 12.

Hefei National Laboratory for Physical Sciences at Microscale, The First Affiliated Hospital of USTC, USTC-SJH Joint Center for Human Reproduction and Genetics, The CAS Key Laboratory of Innate Immunity and Chronic Diseases, School of Life Sciences, CAS Center for Excellence in Molecular Cell Science, Collaborative Innovation Center of Genetics and Development, University of Science and Technology of China, Hefei, 230027, China.

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http://www.nature.com/articles/s41436-018-0015-7
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http://dx.doi.org/10.1038/s41436-018-0015-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6752308PMC
January 2019
62 Reads
7.330 Impact Factor

Correction: A homozygous FANCM frameshift pathogenic variant causes male infertility.

Genet Med 2019 01;21(1):266

Hefei National Laboratory for Physical Sciences at Microscale, The First Affiliated Hospital of USTC, USTC-SJH Joint Center for Human Reproduction and Genetics, The CAS Key Laboratory of Innate Immunity and Chronic Diseases, School of Life Sciences, CAS Center for Excellence in Molecular Cell Science, Collaborative Innovation Center of Genetics and Development, University of Science and Technology of China, Hefei 230027, China.

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http://www.nature.com/articles/s41436-018-0127-0
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http://dx.doi.org/10.1038/s41436-018-0127-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6752282PMC
January 2019
78 Reads
7.330 Impact Factor

Complete Local and Abscopal Responses from a Combination of Radiation and Nivolumab in Refractory Hodgkin's Lymphoma.

Radiat Res 2018 09 27;190(3):322-329. Epub 2018 Jun 27.

Department of a   Internal Medicine, Houston Methodist Research Institute, Houston, Texas 77030.

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http://dx.doi.org/10.1667/RR15048.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135239PMC
September 2018
71 Reads
2.911 Impact Factor

Harnessing and Optimizing the Interplay between Immunotherapy and Radiotherapy to Improve Survival Outcomes.

Mol Cancer Res 2018 08 28;16(8):1209-1214. Epub 2018 Mar 28.

Department of Radiation Oncology, the Houston Methodist Research Institute, Weil Cornell Medical College, Houston, Texas.

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http://dx.doi.org/10.1158/1541-7786.MCR-17-0743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072560PMC
August 2018
14 Reads
4.380 Impact Factor

The small heat shock protein HSPB1 protects mice from sepsis.

Sci Rep 2018 08 21;8(1):12493. Epub 2018 Aug 21.

Department of Surgery and Emory Critical Care Center, Emory University School of Medicine, Atlanta, GA, Georgia.

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http://dx.doi.org/10.1038/s41598-018-30752-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104051PMC
August 2018
42 Reads
5.080 Impact Factor

β1-Integrin Impacts Rad51 Stability and DNA Double-Strand Break Repair by Homologous Recombination.

Mol Cell Biol 2018 05 16;38(9). Epub 2018 Apr 16.

Department of Radiation Oncology, Weill Cornell Medical College, The Houston Methodist Research Institute, Houston, Texas, USA

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http://dx.doi.org/10.1128/MCB.00672-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902589PMC
May 2018
27 Reads
4.780 Impact Factor

MOF influences meiotic expansion of H2AX phosphorylation and spermatogenesis in mice.

PLoS Genet 2018 05 24;14(5):e1007300. Epub 2018 May 24.

Hefei National Laboratory for Physical Sciences at the Microscale, USTC-SJH Joint Center for Human Reproduction and Genetics, The CAS Key Laboratory of Innate Immunity and Chronic Diseases, School of Life Sciences, CAS Center for Excellence in Molecular Cell Science, University of Science and Technology of China (USTC), Collaborative Innovation Center of Genetics and Development, Hefei, Anhui, China.

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http://dx.doi.org/10.1371/journal.pgen.1007300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019819PMC
May 2018
17 Reads

SMARCAD1 Phosphorylation and Ubiquitination Are Required for Resection during DNA Double-Strand Break Repair.

iScience 2018 04;2:123-135

Department of Radiation Oncology, Houston Methodist Cancer Center, The Houston Methodist Research Institute, Weill Cornell Medical College, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.isci.2018.03.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993204PMC
April 2018
34 Reads

MOF Suppresses Replication Stress and Contributes to Resolution of Stalled Replication Forks.

Mol Cell Biol 2018 03 27;38(6). Epub 2018 Feb 27.

Department of Radiation Oncology, Weill Cornell Medical College, The Houston Methodist Research Institute, Houston, Texas, USA

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http://dx.doi.org/10.1128/MCB.00484-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829482PMC
March 2018
23 Reads
4.780 Impact Factor

Cross Talk between Radiation and Immunotherapy: The Twain Shall Meet.

Radiat Res 2018 03 20;189(3):219-224. Epub 2017 Dec 20.

b   Department of Radiation Oncology, The Houston Methodist Research Institute, Weil Cornell Medical College, Houston Texas 77030.

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http://dx.doi.org/10.1667/RR14941.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858718PMC
March 2018
26 Reads
2 Citations
2.911 Impact Factor

HER2 Confers Resistance to Foretinib Inhibition of MET-Amplified Esophageal Adenocarcinoma Cells.

Ann Thorac Surg 2018 Feb 7;105(2):363-370. Epub 2017 Dec 7.

Department of Thoracic and Cardiovascular Surgery, MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1016/j.athoracsur.2017.09.003DOI Listing
February 2018
60 Reads
3.850 Impact Factor

Differentiation of Human Induced Pluripotent or Embryonic Stem Cells Decreases the DNA Damage Repair by Homologous Recombination.

Stem Cell Reports 2017 11 2;9(5):1660-1674. Epub 2017 Nov 2.

Department of Radiation Oncology, Weill Cornell Medical College, The Houston Methodist Hospital Research Institute, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2017.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831054PMC
November 2017
27 Reads
1 Citation

Erratum: miR-15a/miR-16 down-regulates BMI1, impacting Ub-H2A mediated DNA repair and breast cancer cell sensitivity to doxorubicin.

Sci Rep 2017 10 10;7(1):12932. Epub 2017 Oct 10.

Centre for Chemical Biology, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad, Telangana State, 500007, India.

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http://dx.doi.org/10.1038/s41598-017-12314-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635132PMC
October 2017
44 Reads
5.080 Impact Factor

The many faces of histone H3K79 methylation.

Mutat Res Rev Mutat Res 2016 Apr-Jun;768:46-52. Epub 2016 Mar 31.

Chromatin and Epigenetics Lab, Department of Biotechnology, University of Kashmir, Srinagar, Jammu, Kashmir 190006, India. Electronic address:

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http://dx.doi.org/10.1016/j.mrrev.2016.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889126PMC
July 2017
8 Reads
13 Citations
6.213 Impact Factor

Histone acetyltransferase KAT8 is essential for mouse oocyte development by regulating reactive oxygen species levels.

Development 2017 06 15;144(12):2165-2174. Epub 2017 May 15.

Molecular and Cell Genetics Laboratory, The CAS Key Laboratory of Innate Immunity and Chronic Diseases, Hefei National Laboratory for Physical Sciences at Microscale, School of Life Sciences, CAS Center for Excellence in Molecular Cell Science, University of Science and Technology of China, Collaborative Innovation Center of Genetics and Development, Collaborative Innovation Center for Cancer Medicine, Hefei, Anhui 230027, China

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http://dx.doi.org/10.1242/dev.149518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482993PMC
June 2017
114 Reads
3 Citations
6.462 Impact Factor

miR-15a/miR-16 down-regulates BMI1, impacting Ub-H2A mediated DNA repair and breast cancer cell sensitivity to doxorubicin.

Sci Rep 2017 06 27;7(1):4263. Epub 2017 Jun 27.

Centre for Chemical Biology, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad, Telangana State, 500007, India.

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http://dx.doi.org/10.1038/s41598-017-02800-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487337PMC
June 2017
23 Reads
4 Citations
5.080 Impact Factor

Histone Acetyltransferase Activity of MOF Is Required for Leukemogenesis.

Cancer Res 2017 04 15;77(7):1753-1762. Epub 2017 Feb 15.

Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-2374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501293PMC
April 2017
23 Reads
3 Citations
9.330 Impact Factor

MCL-1 Depletion Impairs DNA Double-Strand Break Repair and Reinitiation of Stalled DNA Replication Forks.

Mol Cell Biol 2017 02 19;37(3). Epub 2017 Jan 19.

Department of Radiation Oncology, The Houston Methodist Research Institute, Houston, Texas, USA

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http://dx.doi.org/10.1128/MCB.00535-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247612PMC
February 2017
35 Reads
3 Citations
4.780 Impact Factor

A multifaceted role for MOF histone modifying factor in genome maintenance.

Mech Ageing Dev 2017 01 30;161(Pt A):177-180. Epub 2016 Mar 30.

Department of Radiation Oncology, The Houston Methodist Research Institute, Houston, TX 77030, United States. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045309PMC
http://dx.doi.org/10.1016/j.mad.2016.03.012DOI Listing
January 2017
25 Reads
3.400 Impact Factor

Nuclear functions of β2-Spectrin in genomic stability.

Aging (Albany NY) 2016 12;8(12):3151-3152

Department of Radiation Oncology, Weill Cornell Medical College, The Methodist Hospital Research Institute, Houston, TX 77030, . USA.

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http://dx.doi.org/10.18632/aging.101147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5270656PMC
December 2016
16 Reads
6.432 Impact Factor

Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes.

Nat Commun 2016 10 5;7:13049. Epub 2016 Oct 5.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Sealy Center for Molecular Medicine, University of Texas Medical Branch, Galveston, Texas 77555, USA.

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http://dx.doi.org/10.1038/ncomms13049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059474PMC
October 2016
31 Reads
15 Citations
10.742 Impact Factor

Endocrine disrupting chemical, bisphenol-A, induces breast cancer associated gene HOXB9 expression in vitro and in vivo.

Gene 2016 Sep 13;590(2):234-43. Epub 2016 May 13.

Epigenetics Research Laboratory, Department of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, TX 76019, United States. Electronic address:

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http://dx.doi.org/10.1016/j.gene.2016.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975976PMC
September 2016
25 Reads
4 Citations
2.140 Impact Factor

Emerging therapeutic targets in esophageal adenocarcinoma.

Oncotarget 2016 Jul;7(30):48644-48655

Department of Radiation Oncology, The Houston Methodist Research Institute, Houston, TX, USA.

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http://dx.doi.org/10.18632/oncotarget.8777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217045PMC
July 2016
27 Reads
3 Citations
6.360 Impact Factor

Pluripotent Stem Cells and DNA Damage Response to Ionizing Radiations.

Radiat Res 2016 07 22;186(1):17-26. Epub 2016 Jun 22.

Department of Radiation Oncology, The Houston Methodist Research Institute, Weill Cornell Medical College, The Houston Methodist Hospital, Houston, Texas 77030.

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http://dx.doi.org/10.1667/RR14417.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963261PMC
July 2016
53 Reads
2 Citations
2.911 Impact Factor

β2-spectrin depletion impairs DNA damage repair.

Oncotarget 2016 Jun;7(23):33557-70

Department of Radiation Oncology, Houston Methodist Research Institute, Houston, TX, USA.

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http://dx.doi.org/10.18632/oncotarget.9677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085102PMC
June 2016
16 Reads
4 Citations
6.360 Impact Factor

Torin2 Suppresses Ionizing Radiation-Induced DNA Damage Repair.

Radiat Res 2016 05 2;185(5):527-38. Epub 2016 May 2.

a   Department of Radiation Oncology and.

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http://dx.doi.org/10.1667/RR14373.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4922265PMC
May 2016
34 Reads
3 Citations
2.911 Impact Factor

The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation.

Mol Cell 2016 05;62(3):409-421

St. Patrick Research Group in Basic Oncology, Laval University Cancer Research Center, Quebec City, QC G1R 3S3, Canada; Centre Hospitalier Universitaire de Québec Research Center and School of Medicine, Laval University, Quebec City, QC G1V 4G2, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.03.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887106PMC
May 2016
45 Reads
30 Citations
14.020 Impact Factor

USP7 saves RIDDLE for the end.

Authors:
Tej K Pandita

Cell Cycle 2015 27;14(13):1999. Epub 2015 May 27.

a Department of Radiation Oncology; The Houston Methodist Research Institute ; Houston , TX USA.

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http://dx.doi.org/10.1080/15384101.2015.1049087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5242242PMC
February 2016
3 Reads

Detecting ATM-dependent chromatin modification in DNA damage response.

Methods Mol Biol 2015 ;1288:317-36

Department of Radiation Oncology, Houston Methodist Research Institute, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1007/978-1-4939-2474-5_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556274PMC
December 2015
76 Reads

Role of the Exocyst Complex Component Sec6/8 in Genomic Stability.

Mol Cell Biol 2015 Nov 17;35(21):3633-45. Epub 2015 Aug 17.

Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, USA The Houston Methodist Research Institute, Houston, Texas, USA

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http://dx.doi.org/10.1128/MCB.00768-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589602PMC
November 2015
18 Reads
3 Citations
4.780 Impact Factor

ATM functions at the peroxisome to induce pexophagy in response to ROS.

Nat Cell Biol 2015 Oct 7;17(10):1259-1269. Epub 2015 Sep 7.

Center for Translational Cancer Research, Institute for Biosciences and Technology, Texas A&M University Health Science Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1038/ncb3230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589490PMC
October 2015
33 Reads
58 Citations
19.680 Impact Factor

Targeted inhibition of histone deacetylases and hedgehog signaling suppress tumor growth and homologous recombination in aerodigestive cancers.

Am J Cancer Res 2015 15;5(4):1337-52. Epub 2015 Mar 15.

Division of Molecular Radiation Biology, Department of Radiation Oncology, Harold C. Simmons Comprehensive Cancer Center, University of Texas at Southwestern Medical Center Dallas, TX, USA ; Anchorage and Valley Radiation Therapy Center Anchorage, AK, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473314PMC
June 2015
24 Reads
2 Citations
3.970 Impact Factor

BRUCE regulates DNA double-strand break response by promoting USP8 deubiquitination of BRIT1.

Proc Natl Acad Sci U S A 2015 Mar 2;112(11):E1210-9. Epub 2015 Mar 2.

Department of Cancer and Cell Biology, College of Medicine, University of Cincinnati, Cincinnati, OH 45267;

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http://dx.doi.org/10.1073/pnas.1418335112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371995PMC
March 2015
7 Reads
8 Citations
9.810 Impact Factor

Single-strand DNA-binding protein SSB1 facilitates TERT recruitment to telomeres and maintains telomere G-overhangs.

Cancer Res 2015 Mar 14;75(5):858-69. Epub 2015 Jan 14.

Department of Radiation Oncology, The Houston Methodist Research Institute, Houston, Texas. Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-2289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351820PMC
March 2015
35 Reads
5 Citations
9.330 Impact Factor

Constitutive and ligand-induced EGFR signalling triggers distinct and mutually exclusive downstream signalling networks.

Nat Commun 2014 Dec 15;5:5811. Epub 2014 Dec 15.

1] Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA [2] Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA [3] VA North Texas Health Care System, Dallas, Texas 75216, USA.

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http://dx.doi.org/10.1038/ncomms6811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268886PMC
December 2014
47 Reads
20 Citations
10.742 Impact Factor

Promoter-proximal transcription factor binding is transcriptionally active when coupled with nucleosome repositioning in immediate vicinity.

Nucleic Acids Res 2014 Sep 31;42(15):9602-11. Epub 2014 Jul 31.

GNR Center for Genome Informatics, Institute of Genomics and Integrative Biology, Delhi, India Proteomics and Structural Biology Unit, Institute of Genomics and Integrative Biology, Delhi, India

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http://dx.doi.org/10.1093/nar/gku596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150765PMC
September 2014
59 Reads
5 Citations
9.112 Impact Factor

Unraveling the novel function of the DNA repair enzyme 8-oxoguanine-DNA glycosylase in activating key signaling pathways.

Authors:
Tej K Pandita

Free Radic Biol Med 2014 Aug 27;73:439-40. Epub 2014 May 27.

The Houston Methodist Research Institute, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2014.05.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151468PMC
August 2014
46 Reads
4 Citations
5.740 Impact Factor

MOF phosphorylation by ATM regulates 53BP1-mediated double-strand break repair pathway choice.

Cell Rep 2014 Jul 19;8(1):177-89. Epub 2014 Jun 19.

Deparment of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO 63108, USA; Department of Radiation Oncology, The Houston Methodist Research Institute, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.05.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300955PMC
July 2014
21 Reads
40 Citations
7.210 Impact Factor

Human single-stranded DNA binding protein 1 (hSSB1/NABP2) is required for the stability and repair of stalled replication forks.

Nucleic Acids Res 2014 Jun 20;42(10):6326-36. Epub 2014 Apr 20.

Genome Stability Laboratory, Cancer and Ageing Research Program, Institute of Health and Biomedical Innovation, Translational Research Institute, Queensland University of Technology, Woolloongabba, Queensland, 4102, Australia

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http://dx.doi.org/10.1093/nar/gku276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041449PMC
June 2014
34 Reads
17 Citations
9.112 Impact Factor

Phosphorylation of ribosomal protein S6 confers PARP inhibitor resistance in BRCA1-deficient cancers.

Oncotarget 2014 May;5(10):3375-85

Cancer Biology Division, Department of Radiation Oncology, Washington University School of Medicine, Saint Louis, MO 63108.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102816PMC
http://dx.doi.org/10.18632/oncotarget.1952DOI Listing
May 2014
19 Reads
15 Citations
6.360 Impact Factor

Argonaute-1 functions as a mitotic regulator by controlling Cyclin B during Drosophila early embryogenesis.

FASEB J 2014 Feb 28;28(2):655-66. Epub 2013 Oct 28.

2Centre for Chemical Biology, Indian Institute of Chemical Technology, Uppal Road, Hyderabad 500607, India.

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http://dx.doi.org/10.1096/fj.13-231167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191000PMC
February 2014
6 Reads
4 Citations
5.043 Impact Factor

Role of 53BP1 in the regulation of DNA double-strand break repair pathway choice.

Radiat Res 2014 Jan 9;181(1):1-8. Epub 2013 Dec 9.

Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75390.

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http://dx.doi.org/10.1667/RR13572.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133096PMC
January 2014
28 Reads
22 Citations
2.911 Impact Factor

A Perspective on Chromosomal Double Strand Break Markers in Mammalian Cells.

Jacobs J Radiat Oncol 2014;1(1)

Weill Cornell Medical College of Cornell University, New York, NY 10065, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299656PMC
January 2014
5 Reads
8 Citations

The role of inflammatory pathways in cancer-associated cachexia and radiation resistance.

Mol Cancer Res 2013 Sep 20;11(9):967-72. Epub 2013 Jun 20.

University of Texas Southwestern Medical Center, Department of Radiation Oncology, 5801 Forest Park Road, Dallas, TX 75235.

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http://dx.doi.org/10.1158/1541-7786.MCR-13-0189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133095PMC
September 2013
7 Reads
8 Citations
4.380 Impact Factor

A protective Hsp70-TLR4 pathway in lethal oxidant lung injury.

J Immunol 2013 Aug 1;191(3):1393-403. Epub 2013 Jul 1.

Section of Pulmonary, Critical Care, and Sleep Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.

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http://dx.doi.org/10.4049/jimmunol.1300052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730854PMC
August 2013
47 Reads
10 Citations
4.922 Impact Factor

T-cell-specific deletion of Mof blocks their differentiation and results in genomic instability in mice.

Mutagenesis 2013 May 5;28(3):263-70. Epub 2013 Feb 5.

Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, TX 75229, USA.

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http://dx.doi.org/10.1093/mutage/ges080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630520PMC
May 2013
25 Reads
15 Citations
2.793 Impact Factor

Histone H4 lysine 16 acetylated isoform synthesis opens new route to biophysical studies.

Authors:
Tej K Pandita

Proteomics 2013 May;13(10-11):1546-7

Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1002/pmic.201300145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151460PMC
May 2013
1 Read
3 Citations
3.810 Impact Factor

Histone modifications and DNA double-strand break repair after exposure to ionizing radiations.

Radiat Res 2013 Apr 1;179(4):383-92. Epub 2013 Feb 1.

University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

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http://dx.doi.org/10.1667/RR3308.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133051PMC
April 2013
93 Reads
31 Citations
2.911 Impact Factor

Genome-wide distribution of histone H4 Lysine 16 acetylation sites and their relationship to gene expression.

Genome Integr 2013 Apr 12;4(1). Epub 2013 Apr 12.

Department of Radiation Oncology, Division of Molecular Radiation Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1186/2041-9414-4-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667149PMC
April 2013
15 Reads
19 Citations

Chromatin modifications and the DNA damage response to ionizing radiation.

Front Oncol 2012 22;2:214. Epub 2013 Jan 22.

Department of Radiation Oncology, University of Texas Southwestern Medical Center Dallas, TX, USA.

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http://dx.doi.org/10.3389/fonc.2012.00214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551241PMC
January 2013
28 Reads
19 Citations

Human exonuclease 5 is a novel sliding exonuclease required for genome stability.

J Biol Chem 2012 Dec 24;287(51):42773-83. Epub 2012 Oct 24.

Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1074/jbc.M112.422444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522276PMC
December 2012
10 Reads
3 Citations
4.573 Impact Factor

Alteration/deficiency in activation-3 (Ada3) plays a critical role in maintaining genomic stability.

Cell Cycle 2012 Nov 24;11(22):4266-74. Epub 2012 Oct 24.

Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE, USA.

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http://dx.doi.org/10.4161/cc.22613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3524221PMC
November 2012
9 Reads
10 Citations

14th International Workshop on Ataxia-Telangiectasia ATW2012.

Authors:
Tej K Pandita

DNA Repair (Amst) 2012 Oct 24;11(10):853-6. Epub 2012 Aug 24.

Department of Radiation Oncology, University of Texas South Western Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133112PMC
October 2012
1 Read
1 Citation

Targeting of Nrf2 induces DNA damage signaling and protects colonic epithelial cells from ionizing radiation.

Proc Natl Acad Sci U S A 2012 Oct 8;109(43):E2949-55. Epub 2012 Oct 8.

Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9039, USA.

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http://dx.doi.org/10.1073/pnas.1207718109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491493PMC
October 2012
21 Reads
38 Citations
9.810 Impact Factor

Preferential repair of DNA double-strand break at the active gene in vivo.

J Biol Chem 2012 Oct 21;287(43):36414-22. Epub 2012 Aug 21.

Department of Biochemistry and Molecular Biology, Southern Illinois University, School of Medicine, Carbondale, Illinois 62901, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3476307PMC
October 2012
20 Reads
7 Citations
4.573 Impact Factor

The proteasome activator PA200 regulates tumor cell responsiveness to glutamine and resistance to ionizing radiation.

Mol Cancer Res 2012 Jul 1;10(7):937-44. Epub 2012 May 1.

Department of Immunology, Roswell Park Cancer Institute, Buffalo, New York, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5261820PMC
July 2012
82 Reads
5 Citations
4.380 Impact Factor

Does PTEN loss impair DNA double-strand break repair by homologous recombination?

Clin Cancer Res 2012 Feb 16;18(4):920-2. Epub 2011 Dec 16.

Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-3131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151559PMC
February 2012
7 Reads
7 Citations
8.722 Impact Factor

E2FBP1 antagonizes the p16(INK4A)-Rb tumor suppressor machinery for growth suppression and cellular senescence by regulating promyelocytic leukemia protein stability.

Int J Oral Sci 2011 Oct;3(4):200-8

Department of Immunology, Tulane National Primate Research Center, Covington, LA 70433, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469977PMC
October 2011
4 Reads
5 Citations
2.030 Impact Factor

Tip60-mediated acetylation activates transcription independent apoptotic activity of Abl.

Mol Cancer 2011 Jul 22;10:88. Epub 2011 Jul 22.

Department of Microbiology and Molecular Genetics, Pittsburgh, PA 15240, USA.

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http://dx.doi.org/10.1186/1476-4598-10-88DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157453PMC
July 2011
3 Reads
13 Citations
4.260 Impact Factor

Purkinje cell-specific males absent on the first (mMof) gene deletion results in an ataxia-telangiectasia-like neurological phenotype and backward walking in mice.

Proc Natl Acad Sci U S A 2011 Mar 14;108(9):3636-41. Epub 2011 Feb 14.

Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1073/pnas.1016524108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048124PMC
March 2011
14 Reads
24 Citations
9.810 Impact Factor

Rad52 inactivation is synthetically lethal with BRCA2 deficiency.

Proc Natl Acad Sci U S A 2011 Jan 8;108(2):686-91. Epub 2010 Dec 8.

Department of Radiation Oncology, Washington University, St. Louis, MO 63108, USA.

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http://dx.doi.org/10.1073/pnas.1010959107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021033PMC
January 2011
4 Reads
100 Citations
9.810 Impact Factor

Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint.

Nature 2010 Sep 5;467(7313):343-6. Epub 2010 Sep 5.

Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1038/nature09350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2940944PMC
September 2010
16 Reads
51 Citations
42.351 Impact Factor

MOF and histone H4 acetylation at lysine 16 are critical for DNA damage response and double-strand break repair.

Mol Cell Biol 2010 Jul 17;30(14):3582-95. Epub 2010 May 17.

Washington University School of Medicine, St. Louis, Missouri 63108, USA.

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http://dx.doi.org/10.1128/MCB.01476-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2897562PMC
July 2010
37 Reads
106 Citations
4.780 Impact Factor

Epigenetic inactivation of the potential tumor suppressor gene FOXF1 in breast cancer.

Cancer Res 2010 Jul 29;70(14):6047-58. Epub 2010 Jun 29.

Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-1576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909657PMC
July 2010
25 Reads
29 Citations
9.330 Impact Factor

Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks.

Nucleic Acids Res 2010 Apr 17;38(6):1821-31. Epub 2009 Dec 17.

Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia.

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http://dx.doi.org/10.1093/nar/gkp1164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847229PMC
April 2010
23 Reads
68 Citations
9.112 Impact Factor

Molecular parameters of hyperthermia for radiosensitization.

Crit Rev Eukaryot Gene Expr 2009 ;19(3):235-51

Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri 63108, USA.

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http://dx.doi.org/10.1615/critreveukargeneexpr.v19.i3.50DOI Listing
December 2009
4 Reads
8 Citations
1.571 Impact Factor

HSSB1 and hSSB2 form similar multiprotein complexes that participate in DNA damage response.

J Biol Chem 2009 Aug 14;284(35):23525-31. Epub 2009 Jul 14.

Laboratory of Genetics, NIA, National Institutes of Health, NIH Biomedical Research Center, Baltimore, Maryland 21224, USA.

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http://dx.doi.org/10.1074/jbc.C109.039586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2749126PMC
August 2009
26 Reads
46 Citations
4.573 Impact Factor

Absence of IFN-beta impairs antigen presentation capacity of splenic dendritic cells via down-regulation of heat shock protein 70.

J Immunol 2009 Jul;183(2):1099-109

Department of Molecular Biotechnology, Molecular Immunology Group, Helmholtz Centre for Infection Research, HZI, Braunschweig, Germany.

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http://dx.doi.org/10.4049/jimmunol.0803214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756009PMC
July 2009
15 Reads
16 Citations
4.922 Impact Factor

Altered states of telomere deprotection and the two-stage mechanism of replicative aging.

Mol Cell Biol 2009 May 17;29(9):2390-7. Epub 2009 Feb 17.

Department of Cell Biology, UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9039, USA.

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http://dx.doi.org/10.1128/MCB.01569-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2668373PMC
May 2009
18 Reads
7 Citations
4.780 Impact Factor

Detecting ATM-dependent chromatin modification in DNA damage and heat shock response.

Methods Mol Biol 2009 ;523:395-410

Washington University School of Medicine, St Louis, MO, USA.

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http://dx.doi.org/10.1007/978-1-59745-190-1_26DOI Listing
May 2009
24 Reads
4 Citations

Telomere recombination requires the MUS81 endonuclease.

Nat Cell Biol 2009 May 12;11(5):616-23. Epub 2009 Apr 12.

Department of Radiation Oncology, Washington University School of Medicine, 4511 Forest Park, St. Louis, MO 63108, USA.

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http://dx.doi.org/10.1038/ncb1867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2675667PMC
May 2009
5 Reads
42 Citations
19.680 Impact Factor

Chromatin remodeling finds its place in the DNA double-strand break response.

Nucleic Acids Res 2009 Apr 12;37(5):1363-77. Epub 2009 Jan 12.

Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63108, USA.

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http://dx.doi.org/10.1093/nar/gkn1071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2655678PMC
April 2009
30 Reads
56 Citations
9.112 Impact Factor

MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks.

J Exp Med 2009 Mar 16;206(3):669-79. Epub 2009 Feb 16.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1084/jem.20081326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699138PMC
March 2009
38 Reads
44 Citations
12.520 Impact Factor

Negative Regulation of AKT Activation by BRCA1.

Cancer Res 2008 Dec;68(24):10040-4

Department of Radiation Oncology, Washington University School of Medicine, St Louis, Missouri 63108, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-3009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2605656PMC
December 2008
27 Reads
44 Citations
9.330 Impact Factor

HP1-beta is required for development of the cerebral neocortex and neuromuscular junctions.

J Cell Biol 2008 Nov;183(4):597-606

Division of Immunoepigenetics, Department of Immunology and Cell Biology, Research Center Borstel, Borstel, Germany.

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http://dx.doi.org/10.1083/jcb.200804041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582898PMC
November 2008
20 Reads
38 Citations
9.834 Impact Factor

Role for proteasome activator PA200 and postglutamyl proteasome activity in genomic stability.

Proc Natl Acad Sci U S A 2008 Oct 9;105(42):16165-70. Epub 2008 Oct 9.

Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263.

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http://dx.doi.org/10.1073/pnas.0803145105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570974PMC
October 2008
22 Reads
32 Citations
9.810 Impact Factor

Single-stranded DNA-binding protein hSSB1 is critical for genomic stability.

Nature 2008 May 30;453(7195):677-81. Epub 2008 Apr 30.

Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia.

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http://dx.doi.org/10.1038/nature06883DOI Listing
May 2008
21 Reads
86 Citations
42.351 Impact Factor

Inhibition of telomerase activity enhances hyperthermia-mediated radiosensitization.

Cancer Res 2008 May;68(9):3370-8

Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO 63108, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-5831DOI Listing
May 2008
25 Reads
16 Citations
9.330 Impact Factor

The mammalian ortholog of Drosophila MOF that acetylates histone H4 lysine 16 is essential for embryogenesis and oncogenesis.

Mol Cell Biol 2008 Jan 29;28(1):397-409. Epub 2007 Oct 29.

Department of Radiation Oncology, Washington University School of Medicine, 4511 Forest Park, St. Louis, MO 63108, USA.

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http://dx.doi.org/10.1128/MCB.01045-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2223300PMC
January 2008
14 Reads
86 Citations
4.780 Impact Factor

Defects in coding joint formation in vivo in developing ATM-deficient B and T lymphocytes.

J Exp Med 2007 Jun 14;204(6):1371-81. Epub 2007 May 14.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1084/jem.20061460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118620PMC
June 2007
32 Reads
24 Citations
12.520 Impact Factor

A role for the HOXB7 homeodomain protein in DNA repair.

Cancer Res 2007 Feb;67(4):1527-35

Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-4283DOI Listing
February 2007
7 Reads
24 Citations
9.330 Impact Factor

The cellular control of DNA double-strand breaks.

J Cell Biochem 2006 Dec;99(6):1463-75

Department of Radiation Oncology, Washington University School of Medicine, 4511 Forest Park, St. Louis, MO 63108, USA.

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http://dx.doi.org/10.1002/jcb.21067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3088996PMC
December 2006
8 Reads
24 Citations
3.263 Impact Factor

ATM stabilizes DNA double-strand-break complexes during V(D)J recombination.

Nature 2006 Jul 14;442(7101):466-70. Epub 2006 Jun 14.

Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1038/nature04866DOI Listing
July 2006
13 Reads
147 Citations
42.351 Impact Factor

Role of mammalian Rad9 in genomic stability and ionizing radiation response.

Authors:
Tej K Pandita

Cell Cycle 2006 Jun 15;5(12):1289-91. Epub 2006 Jun 15.

Department of Radiation Oncology, Washington University School of Medicine; 4511 Forest Park Ave., St. Louis, Missouri 63108, USA.

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http://dx.doi.org/10.4161/cc.5.12.2862DOI Listing
June 2006
5 Reads
12 Citations

Role of HSPs and telomerase in radiotherapy.

Authors:
Tej K Pandita

Int J Hyperthermia 2005 Dec;21(8):689-94

Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63108, USA.

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http://dx.doi.org/10.1080/02656730500271700DOI Listing
December 2005
15 Reads
1 Citation
2.645 Impact Factor

Cdt1 transgenic mice develop lymphoblastic lymphoma in the absence of p53.

Oncogene 2005 Dec;24(55):8176-86

Department of Pathology and Immunology, Washington University School of Medicine, Suwon, Korea.

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http://dx.doi.org/10.1038/sj.onc.1208881DOI Listing
December 2005
24 Reads
33 Citations
8.460 Impact Factor

Impaired genomic stability and increased oxidative stress exacerbate different features of Ataxia-telangiectasia.

Hum Mol Genet 2005 Oct 8;14(19):2929-43. Epub 2005 Sep 8.

Department of Neurobiochemistry, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel.

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Publisher Site
http://dx.doi.org/10.1093/hmg/ddi324DOI Listing
October 2005
40 Reads
6 Citations
6.393 Impact Factor

Involvement of human MOF in ATM function.

Mol Cell Biol 2005 Jun;25(12):5292-305

Department of Radiation Oncology, Washington University School of Medicine, 4511 Forest Park, St. Louis, MO 63108, USA.

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http://dx.doi.org/10.1128/MCB.25.12.5292-5305.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1140595PMC
June 2005
14 Reads
83 Citations
4.780 Impact Factor

Manganese superoxide dismutase protects the proliferative capacity of confluent normal human fibroblasts.

J Biol Chem 2005 May 2;280(18):18033-41. Epub 2005 Mar 2.

Free Radical and Radiation Biology Program, Department of Radiation Oncology, the University of Iowa, Iowa City, Iowa 52242, USA.

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http://dx.doi.org/10.1074/jbc.M501939200DOI Listing
May 2005
7 Reads
26 Citations
4.570 Impact Factor

The role of the DNA double-strand break response network in meiosis.

DNA Repair (Amst) 2004 Aug-Sep;3(8-9):1149-64

College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.

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http://dx.doi.org/10.1016/j.dnarep.2004.05.007DOI Listing
February 2005
4 Reads
26 Citations

Lack of PTEN sequesters CHK1 and initiates genetic instability.

Cancer Cell 2005 Feb;7(2):193-204

Institute for Cancer Genetics, Columbia University, New York, New York 10032, USA.

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http://dx.doi.org/10.1016/j.ccr.2005.01.009DOI Listing
February 2005
26 Reads
106 Citations
23.520 Impact Factor

Ataxia-telangiectasia mutated gene controls insulin-like growth factor I receptor gene expression in a deoxyribonucleic acid damage response pathway via mechanisms involving zinc-finger transcription factors Sp1 and WT1.

Endocrinology 2004 Dec 2;145(12):5679-87. Epub 2004 Sep 2.

Department of Clinical Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.

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December 2004
70 Reads
16 Citations
4.500 Impact Factor

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