Teemu Niiranen

Teemu Niiranen

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Teemu Niiranen

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Genome-wide association study of white-coat effect in hypertensive patients.

Blood Press 2019 08 2;28(4):239-249. Epub 2019 May 2.

a Research Program for Clinical and Molecular Metabolism, Faculty of Medicine , University of Helsinki.

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http://dx.doi.org/10.1080/08037051.2019.1604066DOI Listing
August 2019

Emergence of Home Blood Pressure-Guided Management of Hypertension Based on Global Evidence.

Hypertension 2019 Jul 1:HYPERTENSIONAHA11912630. Epub 2019 Jul 1.

Hypertension Center STRIDE-7, School of Medicine, Third Department of Medicine, Sotiria Hospital, National and Kapodistrian University of Athens, Greece (A.K., G.S.S.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.119.12630DOI Listing
July 2019

Early Onset Hypertension Is Associated With Hypertensive End-Organ Damage Already by MidLife.

Hypertension 2019 Jul 1:HYPERTENSIONAHA11913069. Epub 2019 Jul 1.

From the Division of Medicine, Turku University Hospital, University of Turku, Finland (K.S., T.J.N.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.119.13069DOI Listing
July 2019

A Single Visualization Technique for Displaying Multiple Metabolite-Phenotype Associations.

Metabolites 2019 Jul 2;9(7). Epub 2019 Jul 2.

Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.3390/metabo9070128DOI Listing
July 2019

Increased Blood Pressure Variability: A Marker of Augmented Sympathetic Vascular Reactivity?

Authors:
Teemu J Niiranen

Am J Hypertens 2019 May;32(6):533-534

Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland.

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http://dx.doi.org/10.1093/ajh/hpz030DOI Listing
May 2019

The validity of heart failure diagnoses in the Finnish Hospital Discharge Register.

Scand J Public Health 2019 May 9:1403494819847051. Epub 2019 May 9.

1 Division of Medicine, University of Turku and Turku University Hospital, Finland.

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http://dx.doi.org/10.1177/1403494819847051DOI Listing
May 2019

Long-term outcomes with mechanical versus biological aortic valve prosthesis in patients >70 years.

Ann Thorac Surg 2019 May 10. Epub 2019 May 10.

Heart Center, Turku University Hospital and University of Turku, Turku, Finland.

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http://dx.doi.org/10.1016/j.athoracsur.2019.04.012DOI Listing
May 2019

ECG left ventricular hypertrophy as a risk predictor of sudden cardiac death.

Int J Cardiol 2019 Feb 27;276:125-129. Epub 2018 Sep 27.

Research Unit of Internal Medicine, University Hospital of Oulu, University of Oulu, Finland; Division of Preventive Medicine, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S01675273183460
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http://dx.doi.org/10.1016/j.ijcard.2018.09.104DOI Listing
February 2019

Reply.

J Hypertens 2019 Feb;37(2):455

Department of Public Health Solutions, National Institute for Health and Welfare.

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http://dx.doi.org/10.1097/HJH.0000000000001991DOI Listing
February 2019

Home and office blood pressure measurements as determinants of kidney disease in the general population: The Finn-Home Study.

Eur J Prev Cardiol 2019 Jan 25;26(2):208-210. Epub 2018 Jun 25.

1 National Institute for Health and Welfare, Finland.

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http://dx.doi.org/10.1177/2047487318784367DOI Listing
January 2019

Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.

Authors:
Evangelos Evangelou Helen R Warren David Mosen-Ansorena Borbala Mifsud Raha Pazoki He Gao Georgios Ntritsos Niki Dimou Claudia P Cabrera Ibrahim Karaman Fu Liang Ng Marina Evangelou Katarzyna Witkowska Evan Tzanis Jacklyn N Hellwege Ayush Giri Digna R Velez Edwards Yan V Sun Kelly Cho J Michael Gaziano Peter W F Wilson Philip S Tsao Csaba P Kovesdy Tonu Esko Reedik Mägi Lili Milani Peter Almgren Thibaud Boutin Stéphanie Debette Jun Ding Franco Giulianini Elizabeth G Holliday Anne U Jackson Ruifang Li-Gao Wei-Yu Lin Jian'an Luan Massimo Mangino Christopher Oldmeadow Bram Peter Prins Yong Qian Muralidharan Sargurupremraj Nabi Shah Praveen Surendran Sébastien Thériault Niek Verweij Sara M Willems Jing-Hua Zhao Philippe Amouyel John Connell Renée de Mutsert Alex S F Doney Martin Farrall Cristina Menni Andrew D Morris Raymond Noordam Guillaume Paré Neil R Poulter Denis C Shields Alice Stanton Simon Thom Gonçalo Abecasis Najaf Amin Dan E Arking Kristin L Ayers Caterina M Barbieri Chiara Batini Joshua C Bis Tineka Blake Murielle Bochud Michael Boehnke Eric Boerwinkle Dorret I Boomsma Erwin P Bottinger Peter S Braund Marco Brumat Archie Campbell Harry Campbell Aravinda Chakravarti John C Chambers Ganesh Chauhan Marina Ciullo Massimiliano Cocca Francis Collins Heather J Cordell Gail Davies Martin H de Borst Eco J de Geus Ian J Deary Joris Deelen Fabiola Del Greco M Cumhur Yusuf Demirkale Marcus Dörr Georg B Ehret Roberto Elosua Stefan Enroth A Mesut Erzurumluoglu Teresa Ferreira Mattias Frånberg Oscar H Franco Ilaria Gandin Paolo Gasparini Vilmantas Giedraitis Christian Gieger Giorgia Girotto Anuj Goel Alan J Gow Vilmundur Gudnason Xiuqing Guo Ulf Gyllensten Anders Hamsten Tamara B Harris Sarah E Harris Catharina A Hartman Aki S Havulinna Andrew A Hicks Edith Hofer Albert Hofman Jouke-Jan Hottenga Jennifer E Huffman Shih-Jen Hwang Erik Ingelsson Alan James Rick Jansen Marjo-Riitta Jarvelin Roby Joehanes Åsa Johansson Andrew D Johnson Peter K Joshi Pekka Jousilahti J Wouter Jukema Antti Jula Mika Kähönen Sekar Kathiresan Bernard D Keavney Kay-Tee Khaw Paul Knekt Joanne Knight Ivana Kolcic Jaspal S Kooner Seppo Koskinen Kati Kristiansson Zoltan Kutalik Maris Laan Marty Larson Lenore J Launer Benjamin Lehne Terho Lehtimäki David C M Liewald Li Lin Lars Lind Cecilia M Lindgren YongMei Liu Ruth J F Loos Lorna M Lopez Yingchang Lu Leo-Pekka Lyytikäinen Anubha Mahajan Chrysovalanto Mamasoula Jaume Marrugat Jonathan Marten Yuri Milaneschi Anna Morgan Andrew P Morris Alanna C Morrison Peter J Munson Mike A Nalls Priyanka Nandakumar Christopher P Nelson Teemu Niiranen Ilja M Nolte Teresa Nutile Albertine J Oldehinkel Ben A Oostra Paul F O'Reilly Elin Org Sandosh Padmanabhan Walter Palmas Aarno Palotie Alison Pattie Brenda W J H Penninx Markus Perola Annette Peters Ozren Polasek Peter P Pramstaller Quang Tri Nguyen Olli T Raitakari Meixia Ren Rainer Rettig Kenneth Rice Paul M Ridker Janina S Ried Harriëtte Riese Samuli Ripatti Antonietta Robino Lynda M Rose Jerome I Rotter Igor Rudan Daniela Ruggiero Yasaman Saba Cinzia F Sala Veikko Salomaa Nilesh J Samani Antti-Pekka Sarin Reinhold Schmidt Helena Schmidt Nick Shrine David Siscovick Albert V Smith Harold Snieder Siim Sõber Rossella Sorice John M Starr David J Stott David P Strachan Rona J Strawbridge Johan Sundström Morris A Swertz Kent D Taylor Alexander Teumer Martin D Tobin Maciej Tomaszewski Daniela Toniolo Michela Traglia Stella Trompet Jaakko Tuomilehto Christophe Tzourio André G Uitterlinden Ahmad Vaez Peter J van der Most Cornelia M van Duijn Anne-Claire Vergnaud Germaine C Verwoert Veronique Vitart Uwe Völker Peter Vollenweider Dragana Vuckovic Hugh Watkins Sarah H Wild Gonneke Willemsen James F Wilson Alan F Wright Jie Yao Tatijana Zemunik Weihua Zhang John R Attia Adam S Butterworth Daniel I Chasman David Conen Francesco Cucca John Danesh Caroline Hayward Joanna M M Howson Markku Laakso Edward G Lakatta Claudia Langenberg Olle Melander Dennis O Mook-Kanamori Colin N A Palmer Lorenz Risch Robert A Scott Rodney J Scott Peter Sever Tim D Spector Pim van der Harst Nicholas J Wareham Eleftheria Zeggini Daniel Levy Patricia B Munroe Christopher Newton-Cheh Morris J Brown Andres Metspalu Adriana M Hung Christopher J O'Donnell Todd L Edwards Bruce M Psaty Ioanna Tzoulaki Michael R Barnes Louise V Wain Paul Elliott Mark J Caulfield

Nat Genet 2018 12;50(12):1755

William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

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http://www.nature.com/articles/s41588-018-0297-3
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http://dx.doi.org/10.1038/s41588-018-0297-3DOI Listing
December 2018

Feasibility of a checklist in treating hypertension in primary care - base line results from a cluster-randomised controlled trial (check and support).

BMC Cardiovasc Disord 2018 12 19;18(1):240. Epub 2018 Dec 19.

Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.

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http://dx.doi.org/10.1186/s12872-018-0963-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299921PMC
December 2018

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.

Authors:
Evangelos Evangelou Helen R Warren David Mosen-Ansorena Borbala Mifsud Raha Pazoki He Gao Georgios Ntritsos Niki Dimou Claudia P Cabrera Ibrahim Karaman Fu Liang Ng Marina Evangelou Katarzyna Witkowska Evan Tzanis Jacklyn N Hellwege Ayush Giri Digna R Velez Edwards Yan V Sun Kelly Cho J Michael Gaziano Peter W F Wilson Philip S Tsao Csaba P Kovesdy Tonu Esko Reedik Mägi Lili Milani Peter Almgren Thibaud Boutin Stéphanie Debette Jun Ding Franco Giulianini Elizabeth G Holliday Anne U Jackson Ruifang Li-Gao Wei-Yu Lin Jian'an Luan Massimo Mangino Christopher Oldmeadow Bram Peter Prins Yong Qian Muralidharan Sargurupremraj Nabi Shah Praveen Surendran Sébastien Thériault Niek Verweij Sara M Willems Jing-Hua Zhao Philippe Amouyel John Connell Renée de Mutsert Alex S F Doney Martin Farrall Cristina Menni Andrew D Morris Raymond Noordam Guillaume Paré Neil R Poulter Denis C Shields Alice Stanton Simon Thom Gonçalo Abecasis Najaf Amin Dan E Arking Kristin L Ayers Caterina M Barbieri Chiara Batini Joshua C Bis Tineka Blake Murielle Bochud Michael Boehnke Eric Boerwinkle Dorret I Boomsma Erwin P Bottinger Peter S Braund Marco Brumat Archie Campbell Harry Campbell Aravinda Chakravarti John C Chambers Ganesh Chauhan Marina Ciullo Massimiliano Cocca Francis Collins Heather J Cordell Gail Davies Martin H de Borst Eco J de Geus Ian J Deary Joris Deelen Fabiola Del Greco M Cumhur Yusuf Demirkale Marcus Dörr Georg B Ehret Roberto Elosua Stefan Enroth A Mesut Erzurumluoglu Teresa Ferreira Mattias Frånberg Oscar H Franco Ilaria Gandin Paolo Gasparini Vilmantas Giedraitis Christian Gieger Giorgia Girotto Anuj Goel Alan J Gow Vilmundur Gudnason Xiuqing Guo Ulf Gyllensten Anders Hamsten Tamara B Harris Sarah E Harris Catharina A Hartman Aki S Havulinna Andrew A Hicks Edith Hofer Albert Hofman Jouke-Jan Hottenga Jennifer E Huffman Shih-Jen Hwang Erik Ingelsson Alan James Rick Jansen Marjo-Riitta Jarvelin Roby Joehanes Åsa Johansson Andrew D Johnson Peter K Joshi Pekka Jousilahti J Wouter Jukema Antti Jula Mika Kähönen Sekar Kathiresan Bernard D Keavney Kay-Tee Khaw Paul Knekt Joanne Knight Ivana Kolcic Jaspal S Kooner Seppo Koskinen Kati Kristiansson Zoltan Kutalik Maris Laan Marty Larson Lenore J Launer Benjamin Lehne Terho Lehtimäki David C M Liewald Li Lin Lars Lind Cecilia M Lindgren YongMei Liu Ruth J F Loos Lorna M Lopez Yingchang Lu Leo-Pekka Lyytikäinen Anubha Mahajan Chrysovalanto Mamasoula Jaume Marrugat Jonathan Marten Yuri Milaneschi Anna Morgan Andrew P Morris Alanna C Morrison Peter J Munson Mike A Nalls Priyanka Nandakumar Christopher P Nelson Teemu Niiranen Ilja M Nolte Teresa Nutile Albertine J Oldehinkel Ben A Oostra Paul F O'Reilly Elin Org Sandosh Padmanabhan Walter Palmas Aarno Palotie Alison Pattie Brenda W J H Penninx Markus Perola Annette Peters Ozren Polasek Peter P Pramstaller Quang Tri Nguyen Olli T Raitakari Meixia Ren Rainer Rettig Kenneth Rice Paul M Ridker Janina S Ried Harriëtte Riese Samuli Ripatti Antonietta Robino Lynda M Rose Jerome I Rotter Igor Rudan Daniela Ruggiero Yasaman Saba Cinzia F Sala Veikko Salomaa Nilesh J Samani Antti-Pekka Sarin Reinhold Schmidt Helena Schmidt Nick Shrine David Siscovick Albert V Smith Harold Snieder Siim Sõber Rossella Sorice John M Starr David J Stott David P Strachan Rona J Strawbridge Johan Sundström Morris A Swertz Kent D Taylor Alexander Teumer Martin D Tobin Maciej Tomaszewski Daniela Toniolo Michela Traglia Stella Trompet Jaakko Tuomilehto Christophe Tzourio André G Uitterlinden Ahmad Vaez Peter J van der Most Cornelia M van Duijn Anne-Claire Vergnaud Germaine C Verwoert Veronique Vitart Uwe Völker Peter Vollenweider Dragana Vuckovic Hugh Watkins Sarah H Wild Gonneke Willemsen James F Wilson Alan F Wright Jie Yao Tatijana Zemunik Weihua Zhang John R Attia Adam S Butterworth Daniel I Chasman David Conen Francesco Cucca John Danesh Caroline Hayward Joanna M M Howson Markku Laakso Edward G Lakatta Claudia Langenberg Olle Melander Dennis O Mook-Kanamori Colin N A Palmer Lorenz Risch Robert A Scott Rodney J Scott Peter Sever Tim D Spector Pim van der Harst Nicholas J Wareham Eleftheria Zeggini Daniel Levy Patricia B Munroe Christopher Newton-Cheh Morris J Brown Andres Metspalu Adriana M Hung Christopher J O'Donnell Todd L Edwards Bruce M Psaty Ioanna Tzoulaki Michael R Barnes Louise V Wain Paul Elliott Mark J Caulfield

Nat Genet 2018 10 17;50(10):1412-1425. Epub 2018 Sep 17.

William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

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http://dx.doi.org/10.1038/s41588-018-0205-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284793PMC
October 2018

Multisystem Trajectories Over the Adult Life Course and Relations to Cardiovascular Disease and Death.

J Gerontol A Biol Sci Med Sci 2018 Oct 25. Epub 2018 Oct 25.

National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.

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http://dx.doi.org/10.1093/gerona/gly249DOI Listing
October 2018

Incidence rates, correlates, and prognosis of electrocardiographic P-wave abnormalities - a nationwide population-based study.

J Electrocardiol 2017 Nov - Dec;50(6):925-932. Epub 2017 Jul 12.

Department of Health, National Institute for Health and Welfare, Turku, Finland; National Heart, Lung, and Blood Institute's and Boston University's, Framingham Heart Study, Framingham, MA, USA.

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http://dx.doi.org/10.1016/j.jelectrocard.2017.07.004DOI Listing
August 2018

Familial clustering of hypertensive target organ damage in the community.

J Hypertens 2018 05;36(5):1086-1093

National Heart, Lung and Blood Institute's and Boston University's Framingham Heart Study.

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http://dx.doi.org/10.1097/HJH.0000000000001679DOI Listing
May 2018

Optimal Schedule for Assessing Home BP Variability: The Finn-Home Study.

Am J Hypertens 2018 May;31(6):715-725

Chronic Disease Prevention Unit, National Institute for Health and Welfare, Turku, Finland.

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http://dx.doi.org/10.1093/ajh/hpy030DOI Listing
May 2018

Initial Treatment of Hypertension.

N Engl J Med 2018 05;378(20):1952

Joslin Diabetes Center, Boston, MA

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http://dx.doi.org/10.1056/NEJMc1804084DOI Listing
May 2018

Population trends in mitral valve surgery in Finland between 1997 and 2014: the finnish CVD register.

Scand Cardiovasc J 2018 Feb 3;52(1):51-57. Epub 2017 Dec 3.

b National Institute for Health and Welfare , Helsinki , Finland.

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http://dx.doi.org/10.1080/14017431.2017.1405068DOI Listing
February 2018

Thyroid-stimulating hormone and risk of sudden cardiac death, total mortality and cardiovascular morbidity.

Clin Endocrinol (Oxf) 2018 Jan 14;88(1):105-113. Epub 2017 Sep 14.

Department of Health, National Institute for Health and Welfare, Helsinki, Finland.

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http://dx.doi.org/10.1111/cen.13472DOI Listing
January 2018

Morning surge and nocturnal dipping pattern: Two different entities or statistical gymnastics?

J Clin Hypertens (Greenwich) 2017 11 24;19(11):1115-1116. Epub 2017 Sep 24.

Department of Public Health Solutions, National Institute for Health and Welfare, Turku, Finland.

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http://dx.doi.org/10.1111/jch.13072DOI Listing
November 2017

Sex Differences and Similarities in Atrial Fibrillation Epidemiology, Risk Factors, and Mortality in Community Cohorts: Results From the BiomarCaRE Consortium (Biomarker for Cardiovascular Risk Assessment in Europe).

Circulation 2017 Oct 16;136(17):1588-1597. Epub 2017 Oct 16.

From Department of General and Interventional Cardiology, University Heart Center Hamburg, Germany (C.M., F.M.O., S.B., T.Z., R.B.S.); DZHK (German Center for Cardiovascular Research), partner site Hamburg/Kiel/Luebeck, Germany (C.M., S.B., T.Z., R.B.S.); National Heart, Lung and Blood Institute's and Boston University's Framingham Heart Study, MA (T.J.N.); Department of Community Medicine, University of Tromso The Arctic University of Norway, Tromsø (I.N.); Department of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo Neuromed, Pozzilli, Italy (F.G., S.C., M.B.D., G.d.G., L.I.); EPIMED Research Center, Department of Medicine and Surgery, University of Insubria, Varese, Italy (F.G.); National Institute for Health and Welfare, Helsinki, Finland (T.J.N., E.V., P.J., T.P., K.K., V.S.); Catalan Department of Health, Barcelona, Spain (S. Sans); Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Netherlands (G.P.); Center of Excellence for Public Health, Institute of Clinical Sciences, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Northern Ireland (M.H.); Research Center for Prevention and Health, the Capital Region of Denmark, Copenhagen (A.L.); Department of Clinical Experimental Research, Rigshospitalet, Glostrup, Denmark (A.L.); Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark (A.L., T.J.); Department of Epidemiology and Public Health, University College London, UK (M.B.); Laboratory of Experimental Cardiology, University Medical Center Utrecht, Netherlands (H.M.d.R.); Department of Clinical Medicine, Brain and Circulation Research Group, UiT The Arctic University of Norway, Tromsø (E.M.); Research Center for Prevention and Health, Glostrup University Hospital, Denmark (T.J.); Faculty of Medicine, Aalborg University, Denmark (T.J.); Department of Public Health and Clinical Medicine, and Heart Centre, Umeå University, Sweden (S. Söderberg); and Department of Medicine and Surgery, University of Insubria, Varese, Italy (L.I.).

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.117.0
Publisher Site
http://dx.doi.org/10.1161/CIRCULATIONAHA.117.028981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5657474PMC
October 2017

Prognosis of Prehypertension Without Progression to Hypertension.

Circulation 2017 09;136(13):1262-1264

From National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, MA (T.J.N., M.G.L., V.X., R.S.V., S.C.); Department of Biostatistics (M.G.L., V.X.), Department of Medicine, Section of Preventive Medicine (R.S.V.), Department of Medicine, Section of Cardiology (R.S.V.), and Department of Epidemiology (R.S.V.), Boston University School of Public Health, MA; and Department of Medicine, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (E.L.M., S.C.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.029317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658013PMC
September 2017

Risk for hypertension crosses generations in the community: a multi-generational cohort study.

Eur Heart J 2017 Aug;38(29):2300-2308

National Heart, Blood and Lung Institute's and Boston University's Framingham Heart Study, 73 Mt. Wayte Avenue, Suite 2, Framingham, MA 01702, USA.

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http://dx.doi.org/10.1093/eurheartj/ehx134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075041PMC
August 2017

Prevalence, Correlates, and Prognosis of Healthy Vascular Aging in a Western Community-Dwelling Cohort: The Framingham Heart Study.

Hypertension 2017 08 30;70(2):267-274. Epub 2017 May 30.

From the National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, MA (T.J.N., A.L., M.G.L., E.J.B., R.S.V.); Department of Mathematics and Statistics, Boston University, MA (A.L., M.G.L.); Department of Biostatistics (M.G.L.), Evans Department of Medicine, Whitaker Cardiovascular Institute (N.M.H., E.J.B., R.S.V.), Section of Cardiology, Department of Medicine (N.M.H., E.J.B., R.S.V.), Section of Vascular Biology, Department of Medicine (N.M.H.), Section of Preventive Medicine, Department of Medicine (E.J.B., R.S.V.), and Department of Epidemiology (E.J.B., R.S.V.), Boston University School of Public Health, MA; and Cardiovascular Engineering, Inc, Norwood, MA (G.F.M.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.117.09026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509504PMC
August 2017

Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney.

Authors:
Louise V Wain Ahmad Vaez Rick Jansen Roby Joehanes Peter J van der Most A Mesut Erzurumluoglu Paul F O'Reilly Claudia P Cabrera Helen R Warren Lynda M Rose Germaine C Verwoert Jouke-Jan Hottenga Rona J Strawbridge Tonu Esko Dan E Arking Shih-Jen Hwang Xiuqing Guo Zoltan Kutalik Stella Trompet Nick Shrine Alexander Teumer Janina S Ried Joshua C Bis Albert V Smith Najaf Amin Ilja M Nolte Leo-Pekka Lyytikäinen Anubha Mahajan Nicholas J Wareham Edith Hofer Peter K Joshi Kati Kristiansson Michela Traglia Aki S Havulinna Anuj Goel Mike A Nalls Siim Sõber Dragana Vuckovic Jian'an Luan Fabiola Del Greco M Kristin L Ayers Jaume Marrugat Daniela Ruggiero Lorna M Lopez Teemu Niiranen Stefan Enroth Anne U Jackson Christopher P Nelson Jennifer E Huffman Weihua Zhang Jonathan Marten Ilaria Gandin Sarah E Harris Tatijana Zemunik Yingchang Lu Evangelos Evangelou Nabi Shah Martin H de Borst Massimo Mangino Bram P Prins Archie Campbell Ruifang Li-Gao Ganesh Chauhan Christopher Oldmeadow Gonçalo Abecasis Maryam Abedi Caterina M Barbieri Michael R Barnes Chiara Batini John Beilby Tineka Blake Michael Boehnke Erwin P Bottinger Peter S Braund Morris Brown Marco Brumat Harry Campbell John C Chambers Massimiliano Cocca Francis Collins John Connell Heather J Cordell Jeffrey J Damman Gail Davies Eco J de Geus Renée de Mutsert Joris Deelen Yusuf Demirkale Alex S F Doney Marcus Dörr Martin Farrall Teresa Ferreira Mattias Frånberg He Gao Vilmantas Giedraitis Christian Gieger Franco Giulianini Alan J Gow Anders Hamsten Tamara B Harris Albert Hofman Elizabeth G Holliday Jennie Hui Marjo-Riitta Jarvelin Åsa Johansson Andrew D Johnson Pekka Jousilahti Antti Jula Mika Kähönen Sekar Kathiresan Kay-Tee Khaw Ivana Kolcic Seppo Koskinen Claudia Langenberg Marty Larson Lenore J Launer Benjamin Lehne David C M Liewald Li Lin Lars Lind François Mach Chrysovalanto Mamasoula Cristina Menni Borbala Mifsud Yuri Milaneschi Anna Morgan Andrew D Morris Alanna C Morrison Peter J Munson Priyanka Nandakumar Quang Tri Nguyen Teresa Nutile Albertine J Oldehinkel Ben A Oostra Elin Org Sandosh Padmanabhan Aarno Palotie Guillaume Paré Alison Pattie Brenda W J H Penninx Neil Poulter Peter P Pramstaller Olli T Raitakari Meixia Ren Kenneth Rice Paul M Ridker Harriëtte Riese Samuli Ripatti Antonietta Robino Jerome I Rotter Igor Rudan Yasaman Saba Aude Saint Pierre Cinzia F Sala Antti-Pekka Sarin Reinhold Schmidt Rodney Scott Marc A Seelen Denis C Shields David Siscovick Rossella Sorice Alice Stanton David J Stott Johan Sundström Morris Swertz Kent D Taylor Simon Thom Ioanna Tzoulaki Christophe Tzourio André G Uitterlinden Uwe Völker Peter Vollenweider Sarah Wild Gonneke Willemsen Alan F Wright Jie Yao Sébastien Thériault David Conen John Attia Peter Sever Stéphanie Debette Dennis O Mook-Kanamori Eleftheria Zeggini Tim D Spector Pim van der Harst Colin N A Palmer Anne-Claire Vergnaud Ruth J F Loos Ozren Polasek John M Starr Giorgia Girotto Caroline Hayward Jaspal S Kooner Cecila M Lindgren Veronique Vitart Nilesh J Samani Jaakko Tuomilehto Ulf Gyllensten Paul Knekt Ian J Deary Marina Ciullo Roberto Elosua Bernard D Keavney Andrew A Hicks Robert A Scott Paolo Gasparini Maris Laan YongMei Liu Hugh Watkins Catharina A Hartman Veikko Salomaa Daniela Toniolo Markus Perola James F Wilson Helena Schmidt Jing Hua Zhao Terho Lehtimäki Cornelia M van Duijn Vilmundur Gudnason Bruce M Psaty Annette Peters Rainer Rettig Alan James J Wouter Jukema David P Strachan Walter Palmas Andres Metspalu Erik Ingelsson Dorret I Boomsma Oscar H Franco Murielle Bochud Christopher Newton-Cheh Patricia B Munroe Paul Elliott Daniel I Chasman Aravinda Chakravarti Joanne Knight Andrew P Morris Daniel Levy Martin D Tobin Harold Snieder Mark J Caulfield Georg B Ehret

Hypertension 2017 Jul 24. Epub 2017 Jul 24.

From the Department of Health Sciences (L.V.W., A.M.E., N. Shrine, C.B., T.B., M.D.T.), and Department of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre (C.P.N., P.S.B., N.J.S.), University of Leicester, United Kingdom; Department of Epidemiology (A.V., P.J.v.d.M., I.M.N., H. Snieder), Division of Nephrology, Department of Internal Medicine (M.H.d.B., M.A.S.), Interdisciplinary Center Psychopathology and Emotion Regulation (IPCE) (A.J.O., H.R., C.A.H.), Department of Genetics, (M.S.), and Department of Cardiology (P.v.d.H.), University of Groningen, University Medical Center Groningen, The Netherlands; Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Iran (A.V.); Department of Psychiatry, VU University Medical Center, Neuroscience Campus Amsterdam, The Netherlands (R. Jansen); Hebrew SeniorLife, Harvard Medical School, Boston, MA (R. Joehanes); National Heart, Lung and Blood Institute's Framingham Heart Study, MA (R. Joehanes, A.D.J., M. Larson); Institute of Psychiatry, Psychology and Neuroscience (P.F.O.), and Department of Twin Research and Genetic Epidemiology (M.M., C. Menni, T.D.S.), King's College London, United Kingdom; Clinical Pharmacology, William Harvey Research Institute (C.P.C., H.R.W., M.R.B., M. Brown, B.M., M.R., P.B.M., M.J.C.) and NIHR Barts Cardiovascular Biomedical Research Unit (C.P.C., H.R.W., M.R.B., M. Brown, P.B.M., M.J.C.), Barts and The London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA (L.M.R., F.G., P.M.R., D.I.C.); Department of Epidemiology (G.C.V., A. Hofman, A.G.U., O.H.F.), Genetic Epidemiology Unit, Department of Epidemiology (N.A., B.A.O., C.M.v.D.), and Department of Internal Medicine (A.G.U.), Erasmus MC, Rotterdam, The Netherlands; Department of Biological Psychology, Vrije Universiteit, Amsterdam, EMGO+ Institute, VU University Medical Center, The Netherlands (J.-J.H., E.J.d.G., G.W., D.I.B.); Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden (R.J.S., M. Frånberg, A. Hamsten); Centre for Molecular Medicine, Karolinska Universitetsjukhuset, Solna, Sweden (R.J.S., M. Frånberg, A. Hamsten); Estonian Genome Center (T.E., E.O., A. Metspalu), Institute of Biomedicine and Translational Medicine (S.S., M. Laan), and Estonian Genome Center (M.P.), University of Tartu, Estonia; Divisions of Endocrinology/Children's Hospital, Boston, MA (T.E.); Broad Institute of Harvard and MIT, Cambridge, MA (T.E., C.M.L., C.N.-C.); Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (D.E.A., P.N., A. Chakravarti, G.B.E.); The Population Science Branch, Division of Intramural Research, National Heart Lung and Blood Institute (S.-J.H., D.L.), Laboratory of Neurogenetics, National Institute on Aging (M.A.N.), Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute (F.C.), and Center for Information Technology (Y.D., P.J.M., Q.T.N.), National Institutes of Health, Bethesda, MD; The Framingham Heart Study, Framingham, MA (S.-J.H., D.L.); The Institute for Translational Genomics and Population Sciences, Department of Pediatrics (X.G., J.Y.), and The Institute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine (J.I.R.), LABioMed at Harbor-UCLA Medical Center, Torrance, CA; Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland (Z.K., M. Bochud); Swiss Institute of Bioinformatics, Lausanne, Switzerland (Z.K.); Department of Cardiology (S. Trompet, J.W.J.) Department of Gerontology and Geriatrics (S. Trompet), Department of Clinical Epidemiology (R.L.-G., R.d.M., D.O.M.-K.), Department of Molecular Epidemiology (J.D.), and Department of Public Health and Primary Care (D.O.M.-K.), Leiden University Medical Center, The Netherlands; Institute for Community Medicine (A.T.), Department of Internal Medicine B (M.D.), and Interfaculty Institute for Genetics and Functional Genomics (U.V.), University Medicine Greifswald, Germany; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Germany (A.T., M.D., U.V.); Institute of Epidemiology II, Helmholtz Zentrum München, Neuherberg, Germany (J.S.R., A. Peters); Cardiovascular Health Research Unit, Department of Medicine (J.C.B., B.M.P.) and Departments of Biostatistics (K.R.), Epidemiology (B.M.P.), and Health Services (B.M.P.), University of Washington, Seattle; Icelandic Heart Association, Kopavogur, Iceland (A.V.S., V. Gudnason); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (A.V.S., V. Gudnason); Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland (L.-P.L., T.L.); Department of Clinical Chemistry, Faculty of Medicine and Life Sciences, University of Tampere, Finland (L.-P.L., T.L.); Wellcome Trust Centre for Human Genetics (A. Mahajan, A.G., M. Farrall, T.F., C.M.L., H.W., A.P.M.), and Division of Cardiovascular Medicine, Radcliffe Department of Medicine (A.G., M. Farrall, H.W.), University of Oxford, United Kingdom; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, United Kingdom (N.J.W., J.L., C.L., R.J.F.L., R.A.S., J.H.Z.); Clinical Division of Neurogeriatrics, Department of Neurology (E.H., R. Schmidt), Institute of Medical Informatics, Statistics and Documentation (E.H.), and Department of Neurology (H. Schmidt), Medical University Graz, Austria; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics (P.K.J., H.C., I.R., S.W., J.F.W.), Centre for Cognitive Ageing and Cognitive Epidemiology (L.M.L., S.E.H., G.D., A.J.G., D.C.M.L., J.M.S., I.J.D.), Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine (A. Campbell), Generation Scotland, Centre for Genomic and Experimental Medicine (A. Campbell, S.P., C.H.), Department of Psychology (G.D., D.C.M.L., A. Pattie, I.J.D.), Alzheimer Scotland Dementia Research Centre (J.M.S.), and Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine (C.H.), University of Edinburgh, Scotland, United Kingdom; Department of Health (K.K., A.S.H., T. Niiranen, P.J., A.J., S. Koskinen, P.K., V.S., M.P.), and Chronic Disease Prevention Unit (J.T.), National Institute for Health and Welfare (THL), Helsinki, Finland; Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano, Italy (M.T., C.M.B., C.F.S., D.T.); Data Tecnica International, Glen Echo, MD (M.A.N.); Medical Genetics, IRCCS-Burlo Garofolo Children Hospital, Trieste, Italy (D.V., G.G., P.G.); Department of Medical, Surgical and Health Sciences, University of Trieste, Italy (D.V., I.G., M. Brumat, M. Cocca, A. Morgan, G.G., P.G.); Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy (F.D.G.M., P.P.P., A.S.P., A.A.H.); Department of Genetics and Genomic Sciences (K.L.A.), The Charles Bronfman Institute for Personalized Medicine (Y.L., E.P.B., R.J.F.L.), and Mindich Child health Development Institute (R.J.F.L.), Icahn School of Medicine at Mount Sinai, New York; Cardiovascular Epidemiology and Genetics, IMIM, and CIBERCV, Barcelona, Spain (J. Marrugat, R.E.); Institute of Genetics and Biophysics A. Buzzati-Traverso, CNR, Napoli, Italy (D.R., T. Nutile, R. Sorice, M. Ciullo); Department of Psychiatry, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin (L.M.L.); UCD Conway Institute, Centre for Proteome Research (L.M.L.), and School of Medicine, Conway Institute (D.C.S.), University College Dublin, Belfield, Ireland; Department of Immunology, Genetics and Pathology, Uppsala Universitet, Science for Life Laboratory, Sweden (S.E., Å. Johansson, U.G.); Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor (A.U.J., M. Boehnke); NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester United Kingdom (C.P.N., P.S.B., N.J.S.); MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine (J.E.H., V.V., J. Marten, A.F.W., J.F.W.), and Medical Genetics Section, Centre for Genomic and Experimental Medicine and MRC Institute of Genetics and Molecular Medicine (S.E.H.), University of Edinburgh, Western General Hospital, Scotland, United Kingdom; Department of Epidemiology and Biostatistics, School of Public Health (W.Z., E.E., J.C.C., H.G., B.L., I.T., A.-C.V.), MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health (M.-R.J., P.E.), School of Public Health (N.P.), International Centre for Circulatory Health (S. Thom), and National Heart and Lung Institute (P.S.), Imperial College London, United Kingdom; Department of Cardiology, Ealing Hospital, London North West Healthcare NHS Trust, Southall, United Kingdom (W.Z., J.C.C., J.S.K.); Department of Medical Biology, Faculty of Medicine, University of Split, Croatia (T.Z.); Department of Hygiene and Epidemiology, University of Ioannina Medical School, Greece (E.E.); Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Scotland, United Kingdom (N. Shah, A.S.F.D., C.N.A.P.); Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad, Pakistan (N. Shah); National Institute for Health Research Biomedical Research Centre, London, United Kingdom (M.M.); Department of Human Genetics, Wellcome Trust Sanger Institute, United Kingdom (B.P.P., E.Z.); INSERM U 1219, Bordeaux Population Health Center, France (G.C., C.T., S.D.); Bordeaux University, France (G.C., C.T., S.D.); Hunter Medical Research Institute, New Lambton, NSW, Australia (C.O., E.G.H., R. Scott, J.A.); Center for Statistical Genetics, Department of Biostatistics, Ann Arbor, MI (G.A.); Department of Genetics and Molecular Biology, Isfahan University of Medical Sciences, Iran (M.A.); Busselton Population Medical Research Institute, Western Australia (J.B., J.H.); PathWest Laboratory Medicine of Western Australia, Nedlands (J.B., J.H.); School of Pathology and Laboratory Medicine (J.B., J.H.), School of Population and Global Health (J.H.), and School of Medicine and Pharmacology (A. James), The University of Western Australia, Nedlands; Imperial College Healthcare NHS Trust, London, United Kingdom (J.C.C., J.S.K.); University of Dundee, Ninewells Hospital & Medical School, United Kingdom (J.C.); Institute of Genetic Medicine (H.J.C.), and Institute of Health and Society (C. Mamasoula), Newcastle University, Newcastle upon Tyne, United Kingdom; Department of Pathology, Amsterdam Medical Center, The Netherlands (J.J.D.); Department of Numerical Analysis and Computer Science, Stockholm University, Sweden (M. Frånberg); Department of Public Health and Caring Sciences, Geriatrics, Uppsala, Sweden (V. Giedraitis); Helmholtz Zentrum Muenchen, Deutsches Forschungszentrum fuer Gesundheit und Umwelt (GmbH), Neuherberg, Germany (C.G.); Department of Psychology, School of Social Sciences, Heriot-Watt University, Edinburgh, United Kingdom (A.J.G.); Intramural Research Program, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging (T.B.H., L.J.L.); Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA (A. Hofman); Center For Life-Course Health Research (M.-R.J.), and Biocenter Oulu (M.-R.J.), University of Oulu, Finland; Unit of Primary Care, Oulu University Hospital, Finland (M.-R.J.); National Heart, Lung and Blood Institute, Cardiovascular Epidemiology and Human Genomics Branch, Bethesda, MD (A.D.J.); Department of Clinical Physiology, Tampere University Hospital, Finland (M.K.); Department of Clinical Physiology, Faculty of Medicine and Life Sciences, University of Tampere, Finland (M.K.); Cardiovascular Research Center (S. Kathiresan, C.N.-C.); Center for Human Genetics (S. Kathiresan), and Center for Human Genetic Research (C.N.-C.), Massachusetts General Hospital, Boston; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA (S. Kathiresan, C.N.-C.); Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, United Kingdom (K.-T.K.); Department of Public Health, Faculty of Medicine, University of Split, Croatia (I.K., O.P.); Cardiology, Department of Specialties of Medicine, Geneva University Hospital, Switzerland (L. Lin, F.M., G.B.E.); Department of Medical Sciences, Cardiovascular Epidemiology (L. Lind, J.S.), and Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory (E.I.), Uppsala University, Sweden; Department of Psychiatry, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands (Y.M., B.W.J.H.P.); School of Molecular, Genetic and Population Health Sciences, University of Edinburgh, Medical School, Teviot Place, Scotland, United Kingdom (A.D.M.); Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston (A.C.M.); British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences (S.P.), and Institute of Cardiovascular and Medical Sciences, Faculty of Medicine (D.J.S.), University of Glasgow, United Kingdom; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland (A. Palotie, S.R., A.-P.S., M.P.); Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada (G.P., S. Thériault); Department of Neurology, General Central Hospital, Bolzano, Italy (P.P.P.); Department of Neurology, University of Lübeck, Germany (P.P.P.); Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Finland (O.T.R.); Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland (O.T.R.); Department of Cardiology, Fujian Provincial Hospital, Fujian Medical University, Fuzhou, China (M.R.); Harvard Medical School, Boston, MA (P.M.R., D.I.C.); Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy (A.R.); Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, Austria (Y.S., H. Schmidt); INSERM U1078, Etablissement Français du Sang, Brest Cedex, France (A.S.P.); Faculty of Health, University of Newcastle, Callaghan, NSW, Australia (R. Scott, J.A.); John Hunter Hospital, New Lambton, NSW, Australia (R. Scott, J.A.); The New York Academy of Medicine, New York (D.S.); IRCCS Neuromed, Pozzilli, Isernia, Italy (R. Sorice, M. Ciullo); Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin 2, Ireland (A.S.); Institute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA (K.D.T.); Division of Genetic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA (K.D.T.); Department of Public Health (C.T.), and Department of Neurology (S.D.), Bordeaux University Hospital, France; Department of Internal Medicine, Lausanne University Hospital, CHUV, Switzerland (P.V.); Population Health Research Institute, McMaster University, Hamilton Ontario, Canada (D.C.); National Heart and Lung Institute, Imperial College London, Hammersmith Hospital Campus, United Kingdom (J.S.K.); Dasman Diabetes Institute, Kuwait (J.T.); Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia (J.T.); Department of Neurosciences and Preventive Medicine, Danube-University Krems, Austria (J.T.); Division of Cardiovascular Sciences, The University of Manchester and Central Manchester University Hospitals NHS Foundation Trust, United Kingdom (B.D.K.); Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem (Y.M.L.); Kaiser Permanent Washington Health Research Institute, Seattle, WA (B.M.P.); Institute of Physiology, University Medicine Greifswald, Karlsburg, Germany (R.R); Department of Pulmonary Physiology and Sleep, Sir Charles Gairdner Hospital, Nedlands, Western Australia (A. James); Population Health Research Institute, St George's, University of London, United Kingdom (D.P.S.); Department of Medicine, Columbia University Medical Center, New York (W.P.); Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, CA (E.I.); Data Science Institute and Lancaster Medical School, Lancaster University, United Kingdom (J.K.); and Department of Biostatistics, University of Liverpool, United Kingdom (A.P.M.).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783787PMC
July 2017

Aortic-Brachial Arterial Stiffness Gradient and Cardiovascular Risk in the Community: The Framingham Heart Study.

Hypertension 2017 06 10;69(6):1022-1028. Epub 2017 Apr 10.

From the National Heart, Blood and Lung Institute's and Boston University's Framingham Heart Study, Framingham, MA (T.J.N., M.G.L., E.J.B., R.S.V.); Center for Clinical Translational Epidemiology and Comparative Effectiveness Research (B.K., R.S.V.), Section of Preventive Medicine, Department of Medicine (B.K., E.J.B., R.S.V.), Department of Biostatistics (M.G.L.), Evans Department of Medicine and Whitaker Cardiovascular Institute (N.M.H., E.J.B., R.S.V.), Section of Cardiology, Department of Medicine (N.M.H., E.J.B., R.S.V.), Section of Vascular Biology, Department of Medicine (N.M.H.), and Department of Epidemiology (E.J.B., R.S.V.), Boston University School of Public Health, MA; and Cardiovascular Engineering, Inc., Norwood, MA (G.F.M.).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5426958PMC
June 2017

Heritability and risks associated with early onset hypertension: multigenerational, prospective analysis in the Framingham Heart Study.

BMJ 2017 May 12;357:j1949. Epub 2017 May 12.

National Heart, Blood and Lung Institute's and Boston University's Framingham Heart Study, Framingham, MA 01702, USA.

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http://dx.doi.org/10.1136/bmj.j1949DOI Listing
May 2017

Outcome-Driven Thresholds for Increased Home Blood Pressure Variability.

Hypertension 2017 04 13;69(4):599-607. Epub 2017 Feb 13.

From the Department of Health, National Institute for Health and Welfare, Turku, Finland (E.P.J., T.J.N., J.K.J., P.J.P., V.L.L., A.M.J.); Division of Medicine (E.P.J.) and Heart Centre (V.L.L.), Turku University Hospital, Finland; Department of Medicine, University of Turku, Finland (E.P.J., A.M.J.); Framingham Heart Study, Boston University, MA (T.J.N.); Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Belgium (L.T., J.A.S.); Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Sciences, Sendai, Japan (K.A., T.O., Y.I.); Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan (K.A., T.O.); Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan (A.H.); Hospital Italiano de Buenos Aires, Argentina (L.S.A.); Department of Public Health, Tohoku University Graduate School of Medicine, Sendai, Japan (I.T.); Hypertension Center STRIDE-7, National and Kapodistrian University of Athens, School of Medicine, Third Department of Medicine, Sotiria Hospital, Greece (G.S.S.); and R&D VitaK Group, Maastricht University, The Netherlands (J.A.S.).

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April 2017

Home versus office blood pressure: longitudinal relations with left ventricular hypertrophy: the Finn-Home study.

J Hypertens 2017 02;35(2):266-271

aDepartment of Health, National Institute for Health and WelfarebUniversity of Turku, Turku, FinlandcFramingham Heart Study, Framingham, Massachusetts, USAdHeart CentreeDivision of Medicine, Turku University Hospital, Turku, Finland.

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February 2017

Association of thyroid-stimulating hormone with lipid concentrations: an 11-year longitudinal study.

Clin Endocrinol (Oxf) 2017 Jan 2;86(1):120-127. Epub 2016 Aug 2.

Department of Health, National Institute for Health and Welfare, Helsinki, Finland.

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http://dx.doi.org/10.1111/cen.13151DOI Listing
January 2017

Trends in rates, patient selection and prognosis of coronary revascularisations in Finland between 1994 and 2013: the CVDR.

EuroIntervention 2016 Oct;12(9):1117-1125

Heart Centre, Turku University Hospital and University of Turku, Turku, Finland.

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http://dx.doi.org/10.4244/EIJV12I9A183DOI Listing
October 2016

Relative Contributions of Arterial Stiffness and Hypertension to Cardiovascular Disease: The Framingham Heart Study.

J Am Heart Assoc 2016 10 26;5(11). Epub 2016 Oct 26.

National Heart, Blood and Lung Institute's and Boston University's Framingham Heart Study, Framingham, MA.

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http://dx.doi.org/10.1161/JAHA.116.004271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210358PMC
October 2016

Health 2000 score - development and validation of a novel cardiovascular risk score.

Ann Med 2016 09 17;48(6):403-409. Epub 2016 May 17.

a Department of Health , National Institute for Health and Welfare , Turku , Finland.

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September 2016

Methodology and technology for peripheral and central blood pressure and blood pressure variability measurement: current status and future directions - Position statement of the European Society of Hypertension Working Group on blood pressure monitoring and cardiovascular variability.

J Hypertens 2016 09;34(9):1665-77

aHypertension Center STRIDE-7, National and Kapodistrian University of Athens, Third Department of Medicine, Sotiria Hospital, Athens, Greece bDepartment of Medicine and Surgery, University of Milan-Bicocca cDepartment of Cardiovascular Neural and Metabolic Sciences, S.Luca Hospital, IRCCS Istituto Auxologico Italiano, Milan, Italy dFirst Department of Cardiology, Hippokration Hospital, Medical School, National and Kapodistrian University of Athens eFourth Department of Medicine, Evangelismos General Hospital, Athens, Greece fFoundation-Medical Research Institutes (F-MRI), France gDepartment of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia hGeriatric Department University Hospital of Nancy, FHU CARTAGE and INSERM U1116 Université de Lorraine, France iUniversité Paris Descartes, Hôpital Européen Georges Pompidou, Assistance Publique Hôpitaux de Paris, France jIRCCS Fondazione Don Carlo Gnocchi, Milan, Italy kDepartment of Medicine, University of Barcelona & Hypertension Unit, Hospital Mutua Terrassa, Spain lStroke and Hypertension Unit, Connolly Hospital, Dublin, Ireland mBaker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia nDepartment of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Sciences, Japan oDivision of Cardiovascular Medicine, Jichi Medical University School of Medicine, Shimotsuke, Japan pHypertension Center, 3rd Department of Medicine, Papageorgiou Hospital, Aristotle University of Thessaloniki, Greece qDepartment of Clinical Therapeutics, National and Kapodistrian University of Athens, Alexandra Hospital, Greece rNuffield Department of Primary Care Health Sciences, University of Oxford, UK sESH Excellence Centre, Kerckhoff Clinic Bad, Nauheim, Germany tNorthern Sydney Local Health District & University of Sydney, Australia uDivision of Cardiology, Sunnybrook Health Sciences Centre, Toronto, Canada vDepartment of Heal

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September 2016

The association between home vs. ambulatory night-time blood pressure and end-organ damage in the general population.

J Hypertens 2016 09;34(9):1730-7

aDivision of Medicine, Turku University Hospital bDepartment of Health, National Institute for Health and Welfare, Turku cDepartment of Health, National Institute for Health and Welfare, Helsinki dDepartment of Medicine, University of Turku, Turku, Finland eThe Framingham Heart Study, Framingham, Massachusetts, USA.

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September 2016

Epidemiology of cardiovascular disease: recent novel outlooks on risk factors and clinical approaches.

Expert Rev Cardiovasc Ther 2016 Jul 25;14(7):855-69. Epub 2016 Apr 25.

a National Heart, Blood and Lung Institute's and Boston University's Framingham Heart Study , Framingham , MA , USA.

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http://dx.doi.org/10.1080/14779072.2016.1176528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961207PMC
July 2016

Comparison of Acceptability of Traditional and Novel Blood Pressure Measurement Methods.

Am J Hypertens 2016 06 13;29(6):679-83. Epub 2015 Oct 13.

Department of Health, National Institute for Health and Welfare, Turku/Helsinki, Finland.

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June 2016

Prevalence and Determinants of Masked Hypertension Among Black Nigerians Compared With a Reference Population.

Hypertension 2016 06 11;67(6):1249-55. Epub 2016 Apr 11.

From the Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium (A.N.O., L.T., A.H., F.-F.W., L.J., J.A.S.); Department of Internal Medicine, Faculty of Clinical Sciences (A.N.O.), Department of Human Physiology (J.O.O.), and Department of Chemical Pathology (M.M.N.), Faculty of Basic Clinical Sciences, College of Health Sciences, University of Abuja, Abuja, Nigeria; Hospital Italiano de Buenos Aires, Buenos Aires, Argentina (L.S.A.); Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan (K.A., T.O.); Department of Health, National Institute for Health and Welfare, Turku, Finland (T.J.N., J.K.J., A.M.J.); Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Sciences, Sendai, Japan (K.A., T.O., Y.I.); Centro de Nefrología and Departamento de Fisiopatología, Hospital de Clínicas, Universidad de la República, Montevideo, Uruguay (J.B., L.L.); Hypertension Center, Third Department of Medicine, University of Athens, Sotiria Hospital, Athens, Greece (G.S.S); Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland (E.O.); and R & D Group VitaK, Maastricht University, Maastricht, The Netherlands (J.A.S.).

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June 2016

Association between thyroid-stimulating hormone and blood pressure in adults: an 11-year longitudinal study.

Clin Endocrinol (Oxf) 2016 May 23;84(5):741-7. Epub 2015 Sep 23.

Department of Health, National Institute for Health and Welfare, Helsinki, Finland.

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May 2016

Self-reported obstructive sleep apnea, simple snoring, and various markers of sleep-disordered breathing as predictors of cardiovascular risk.

Sleep Breath 2016 May 12;20(2):589-96. Epub 2015 Sep 12.

Department of Health, National Institute for Health and Welfare, P.O. Box 57, 20521, Turku, Finland.

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May 2016

Prevalence and prognosis of ECG abnormalities in normotensive and hypertensive individuals.

J Hypertens 2016 May;34(5):959-66

aDepartment of Health, National Institute for Health and Welfare Turku bDivision of Medicine, Turku University Central Hospital, Turku cDivision of Cardiology, Heart and Lung Center, Helsinki University Central Hospital, Helsinki dMedical Research Center, Oulu University Central Hospital and University of Oulu, Oulu eDivision of Internal Medicine, Seinäjoki Central Hospital, Seinäjoki fHeart Center, Tampere University Hospital and School of Medicine, Tampere University gDepartment of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland hFramingham Heart Study, Framingham, Massachusetts, USA.

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May 2016

The impact of the day of the week on home blood pressure: the Finn-Home study.

Blood Press Monit 2016 Apr;21(2):63-8

aChronic Disease Prevention Unit, National Institute for Health and Welfare bDepartment of Medicine cTyks and Turku Region Joint Emergency Services, Turku University Hospital, Turku, Finland.

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April 2016

Prediction of Blood Pressure and Blood Pressure Change With a Genetic Risk Score.

J Clin Hypertens (Greenwich) 2016 Mar 5;18(3):181-6. Epub 2015 Oct 5.

Department of Health, National Institute for Health and Welfare, Turku/Helsinki, Finland.

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http://dx.doi.org/10.1111/jch.12702DOI Listing
March 2016

White-coat and masked hypertension as risk factors for progression to sustained hypertension: the Finn-Home study.

J Hypertens 2016 Jan;34(1):54-60

aDepartment of Health, National Institute for Health and Welfare bDivision of Medicine, Turku University Central Hospital, Turku, Finland.

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January 2016

Agreement between ambulatory, home, and office blood pressure variability.

J Hypertens 2016 Jan;34(1):61-7

aDepartment of Health, National Institute for Health and Welfare bDepartment of Medicine cTyks and Turku Region Joint Emergency Services, Turku University Hospital, Turku, Finland.

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January 2016

ECG left ventricular hypertrophy is a stronger risk factor for incident cardiovascular events in women than in men in the general population.

J Hypertens 2015 Jun;33(6):1284-90

aDivision of Cardiology, Heart and Lung Center, Helsinki University Central Hospital, Helsinki bDivision of Medicine, Turku University Hospital, Turku cDepartment of Health, National Institute for Health and Welfare, Turku/Helsinki dDepartment of Clinical Physiology, University of Tampere eTampere University Hospital, Tampere fInstitute of Clinical Medicine, University of Oulu and University Central Hospital of Oulu, Oulu, Finland.

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http://dx.doi.org/10.1097/HJH.0000000000000553DOI Listing
June 2015

Optimal number of days for home blood pressure measurement.

Am J Hypertens 2015 May 14;28(5):595-603. Epub 2014 Nov 14.

Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium; VitaK Research and Development, Maastricht University, Maastricht, The Netherlands.

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May 2015

Social, lifestyle and demographic inequalities in hypertension care.

Scand J Public Health 2015 May 27;43(3):246-53. Epub 2015 Feb 27.

Department of Health, National Institute for Health and Welfare, Finland.

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http://dx.doi.org/10.1177/1403494815571031DOI Listing
May 2015

Thresholds for conventional and home blood pressure by sex and age in 5018 participants from 5 populations.

Hypertension 2014 Oct 30;64(4):695-701. Epub 2014 Jun 30.

From the Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan (K.N., K.A., T.O.); Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium (K.A., L.T., A. Hara, J.A.S.); Graduate School of Pharmaceutical Sciences (K.A., Y.I.), Tohoku Medical Megabank Organization (A. Hozawa), and Graduate School of Medicine (I.T.), Tohoku University, Sendai, Japan; Population Studies Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku, Finland (T.J.N., J.K.J., A.M.J.); Department of Medicine, Turku University Hospital, Turku, Finland (T.J.N.); Centro de Nefrología and Departamento de Fisiopatología, Hospital de Clínicas, Universidad de la República, Montevideo, Uruguay (I.L., J.B.); the Asociación Española Primera de Socorros Mutuos, Montevideo, Uruguay (E.S.); Hypertension Center, Third Department of Medicine, University of Athens, Sotiria Hospital, Athens, Greece (A.K., G.S.S.); and Department of Epidemiology, Maastricht University, Maastricht, The Netherlands (J.A.S.).

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October 2014

Reference frame for home pulse pressure based on cardiovascular risk in 6470 subjects from 5 populations.

Hypertens Res 2014 Jul 20;37(7):672-8. Epub 2014 Mar 20.

1] Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium [2] Department of Epidemiology, Maastricht University, Maastricht, The Netherlands.

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July 2014

Risk Associated with Pulse Pressure on Out-of-Office Blood Pressure Measurement.

Pulse (Basel) 2014 May 21;2(1-4):42-51. Epub 2014 Nov 21.

Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium ; VitaK Research and Development, Maastricht University, Maastricht, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646147PMC
May 2014

Prognosis of white-coat and masked hypertension: International Database of HOme blood pressure in relation to Cardiovascular Outcome.

Hypertension 2014 Apr 13;63(4):675-82. Epub 2014 Jan 13.

Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Campus Sint Rafaël, Kapucijnenvoer 35, Block D, Box 7001, BE-3000 Leuven, Belgium. or

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April 2014

Lack of impact of a comprehensive intervention on hypertension in the primary care setting.

Am J Hypertens 2014 Mar 1;27(3):489-96. Epub 2013 Nov 1.

Population Studies Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku, Finland.

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http://dx.doi.org/10.1093/ajh/hpt204DOI Listing
March 2014

Overall cardiovascular prognosis of isolated systolic hypertension, isolated diastolic hypertension and pulse pressure defined with home measurements: the Finn-home study.

J Hypertens 2014 Mar;32(3):518-24

aPopulation Studies Unit, National Institute for Health and Welfare, Turku bPopulation Health Research Unit, National Institute for Health and Welfare, Helsinki, Finland.

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March 2014

Risk stratification by self-measured home blood pressure across categories of conventional blood pressure: a participant-level meta-analysis.

PLoS Med 2014 Jan 21;11(1):e1001591. Epub 2014 Jan 21.

Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium ; Department of Epidemiology, Maastricht University, Maastricht, The Netherlands.

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https://dx.plos.org/10.1371/journal.pmed.1001591
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897370PMC
January 2014

Target organ damage and masked hypertension in the general population: the Finn-Home study.

J Hypertens 2013 Jun;31(6):1136-43

Population Studies Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, 20720 Turku, Finland.

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June 2013

Prognostic significance of masked and white-coat hypertension in the general population: the Finn-Home Study.

J Hypertens 2012 Apr;30(4):705-12

Population Studies Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Peltolantie, Turku, Finland.

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April 2012

Prognostic value of the variability in home-measured blood pressure and heart rate: the Finn-Home Study.

Hypertension 2012 Feb 3;59(2):212-8. Epub 2012 Jan 3.

Population Studies Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Peltolantie 3, 20720 Turku, Finland.

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February 2012

Determinants of masked hypertension in the general population: the Finn-Home study.

J Hypertens 2011 Oct;29(10):1880-8

Population Studies Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku, Finland.

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October 2011

Optimal schedule for home blood pressure measurement based on prognostic data: the Finn-Home Study.

Hypertension 2011 Jun 11;57(6):1081-6. Epub 2011 Apr 11.

Population Studies Unit, National Institute for Health and Welfare, Peltolantie, 20720 Turku, Finland.

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June 2011

Factors affecting the difference between morning and evening home blood pressure: the Finn-Home study.

Blood Press 2011 Feb 20;20(1):27-36. Epub 2010 Sep 20.

Population Studies Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Peltolantie 3, Turku, Finland.

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February 2011

Factors affecting the variability of home-measured blood pressure and heart rate: the Finn-home study.

J Hypertens 2010 Sep;28(9):1836-45

Population Studies Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku, Finland.

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September 2010

Home-measured blood pressure is a stronger predictor of cardiovascular risk than office blood pressure: the Finn-Home study.

Hypertension 2010 Jun 12;55(6):1346-51. Epub 2010 Apr 12.

Population Studies Unit, National Institute for Health and Welfare, Turku, Finland.

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June 2010

Comparison of home and ambulatory blood pressure measurement in the diagnosis of masked hypertension.

J Hypertens 2010 Apr;28(4):709-14

Population Studies Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku, Finland.

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April 2010

Optimal schedule for home blood pressure monitoring based on a clinical approach.

J Hypertens 2010 Feb;28(2):259-64

Population Studies Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Peltolantie, Turku, Finland.

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February 2010

[Home blood pressure measurement].

Duodecim 2009 ;125(18):1959-66

Väestötutkimusyksikkö, Turku ja TYKS, sisätaudit.

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January 2010

Home-measured blood pressure is more strongly associated with atherosclerosis than clinic blood pressure: the Finn-HOME Study.

J Hypertens 2007 Jun;25(6):1225-31

Department of Health and Functional Capacity, National Public Health Institute, Helsinki, Finland.

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June 2007

Prevalence and determinants of isolated clinic hypertension in the Finnish population: the Finn-HOME study.

J Hypertens 2006 Mar;24(3):463-70

Department of Health and Functional Capacity, National Public Health Institute, Helsinki/Turku, Finland.

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http://dx.doi.org/10.1097/01.hjh.0000209982.21112.bcDOI Listing
March 2006