Tea Lanisnik Rižner

Tea Lanisnik Rižner

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Tea Lanisnik Rižner

Tea Lanisnik Rižner

Publications by authors named "Tea Lanisnik Rižner"

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Aldo-keto reductase 1C3-Assessment as a new target for the treatment of endometriosis.

Pharmacol Res 2020 Feb 20;152:104446. Epub 2019 Sep 20.

Center of Excellence in Environmental Toxicology & Department of Systems Pharmacology & Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, 421 Curie Boulevard, PA 19104-6160, Philadelphia, USA.

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http://dx.doi.org/10.1016/j.phrs.2019.104446DOI Listing
February 2020

Multiplex analysis of 40 cytokines do not allow separation between endometriosis patients and controls.

Sci Rep 2019 Nov 13;9(1):16738. Epub 2019 Nov 13.

Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, 1000, Ljubljana, Slovenia.

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http://dx.doi.org/10.1038/s41598-019-52899-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853932PMC
November 2019

General toxicity assessment of the novel aldose reductase inhibitor cemtirestat.

Interdiscip Toxicol 2019 Nov 20;12(3):120-128. Epub 2020 Feb 20.

Department of Biochemical Pharmacology, Institute of Experimental Pharmacology and Toxicology, CEM, Slovak Academy of Sciences, Bratislava, Slovakia.

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http://dx.doi.org/10.2478/intox-2019-0014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085302PMC
November 2019

Demonstrating suitability of the Caco-2 cell model for BCS-based biowaiver according to the recent FDA and ICH harmonised guidelines.

J Pharm Pharmacol 2019 Aug 2;71(8):1231-1242. Epub 2019 Jun 2.

Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

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http://dx.doi.org/10.1111/jphp.13111DOI Listing
August 2019

Editorial: Relevance of Steroid Biosynthesis, Metabolism and Transport in Pathophysiology and Drug Discovery.

Front Pharmacol 2019 26;10:245. Epub 2019 Mar 26.

Faculty of Medicine, Institute of Biochemistry, University of Ljubljana, Ljubljana, Slovenia.

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http://dx.doi.org/10.3389/fphar.2019.00245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443981PMC
March 2019

Paramount importance of sample quality in pre-clinical and clinical research-Need for standard operating procedures (SOPs).

J Steroid Biochem Mol Biol 2019 02 24;186:1-3. Epub 2018 Sep 24.

Helmholtz Zentrum München, Research Unit of Molecular Endocrinology and Metabolism, 85764 Neuherberg, Germany; German Centre for Diabetes Research (DZD), Neuherberg, Germany; Lehrstuhl für Experimentelle Genetik, Technische Universität München, Freising-Weihenstephan, Germany.

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http://dx.doi.org/10.1016/j.jsbmb.2018.09.017DOI Listing
February 2019

It is high time to discontinue use of misidentified and contaminated cells: Guidelines for description and authentication of cell lines.

J Steroid Biochem Mol Biol 2018 09 29;182:1-3. Epub 2017 Dec 29.

Helmholtz Zentrum München, Institute of Experimental Genetics, Genome Analysis Centre, 85764 Neuherberg, Germany; German Centre for Diabetes Research (DZD), Neuherberg, Germany; Lehrstuhl für Experimentelle Genetik, Technische Universität München, Freising-Weihenstephan, Germany.

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http://dx.doi.org/10.1016/j.jsbmb.2017.12.017DOI Listing
September 2018

Models including serum CA-125, BMI, cyst pathology, dysmenorrhea or dyspareunia for diagnosis of endometriosis.

Biomark Med 2018 07 5;12(7):737-747. Epub 2018 Jun 5.

Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000, Ljubljana, Slovenia.

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http://dx.doi.org/10.2217/bmm-2017-0426DOI Listing
July 2018

Membrane progesterone receptors β and γ have potential as prognostic biomarkers of endometrial cancer.

J Steroid Biochem Mol Biol 2018 04 17;178:303-311. Epub 2018 Jan 17.

Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Slovenia. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2018.01.011DOI Listing
April 2018

Models including plasma levels of sphingomyelins and phosphatidylcholines as diagnostic and prognostic biomarkers of endometrial cancer.

J Steroid Biochem Mol Biol 2018 04 31;178:312-321. Epub 2018 Jan 31.

Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, 1000, Ljubljana, Slovenia. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2018.01.012DOI Listing
April 2018

Detection of Aristaless-related homeobox protein in ovarian sex cord-stromal tumors.

Exp Mol Pathol 2018 02 21;104(1):38-44. Epub 2017 Dec 21.

Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia. Electronic address:

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http://dx.doi.org/10.1016/j.yexmp.2017.12.005DOI Listing
February 2018

Novel algorithm including CA-125, HE4 and body mass index in the diagnosis of endometrial cancer.

Gynecol Oncol 2017 10 21;147(1):126-132. Epub 2017 Jul 21.

Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia. Electronic address:

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http://dx.doi.org/10.1016/j.ygyno.2017.07.130DOI Listing
October 2017

STAR and AKR1B10 are down-regulated in high-grade endometrial cancer.

J Steroid Biochem Mol Biol 2017 07 21;171:43-53. Epub 2017 Feb 21.

Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2017.02.015DOI Listing
July 2017

Structural basis for inhibition of 17β-hydroxysteroid dehydrogenases by phytoestrogens: The case of fungal 17β-HSDcl.

J Steroid Biochem Mol Biol 2017 07 1;171:80-93. Epub 2017 Mar 1.

Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, SI-1000 Ljubljana, Slovenia.

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http://dx.doi.org/10.1016/j.jsbmb.2017.02.020DOI Listing
July 2017

The Importance of Steroid Uptake and Intracrine Action in Endometrial and Ovarian Cancers.

Front Pharmacol 2017 19;8:346. Epub 2017 Jun 19.

Momentum Membrane Protein Research Group, Research Centre for Natural Sciences, Institute of Enzymology, Hungarian Academy of SciencesBudapest, Hungary.

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http://dx.doi.org/10.3389/fphar.2017.00346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474471PMC
June 2017

The Significance of the Sulfatase Pathway for Local Estrogen Formation in Endometrial Cancer.

Front Pharmacol 2017 23;8:368. Epub 2017 Jun 23.

Institute of Biochemistry, Faculty of Medicine, University of LjubljanaLjubljana, Slovenia.

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http://dx.doi.org/10.3389/fphar.2017.00368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481366PMC
June 2017

Discovery of biomarkers for endometrial cancer: current status and prospects.

Expert Rev Mol Diagn 2016 12 21;16(12):1315-1336. Epub 2016 Nov 21.

a Institute of Biochemistry, Faculty of Medicine , University of Ljubljana , Ljubljana , Slovenia.

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http://dx.doi.org/10.1080/14737159.2016.1258302DOI Listing
December 2016

Pyrithione-based ruthenium complexes as inhibitors of aldo-keto reductase 1C enzymes and anticancer agents.

Dalton Trans 2016 Aug 30;45(29):11791-800. Epub 2016 Jun 30.

Department of Chemistry and Biochemistry, Faculty of Chemistry and Chemical Technology, University of Ljubljana, Večna pot 113, SI-1000 Ljubljana, Slovenia.

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http://dx.doi.org/10.1039/c6dt00668jDOI Listing
August 2016

Altered levels of acylcarnitines, phosphatidylcholines, and sphingomyelins in peritoneal fluid from ovarian endometriosis patients.

J Steroid Biochem Mol Biol 2016 May 24;159:60-9. Epub 2016 Feb 24.

Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09600760163003
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http://dx.doi.org/10.1016/j.jsbmb.2016.02.023DOI Listing
May 2016

Recommendations for description and validation of antibodies for research use.

J Steroid Biochem Mol Biol 2016 Feb 2;156:40-2. Epub 2015 Dec 2.

Helmholtz Zentrum München, Institute of Experimental Genetics, Genome Analysis Center, 85764 Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany; Lehrstuhl für Experimentelle Genetik, Technische Universität München, Freising-Weihenstephan, Germany.

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http://dx.doi.org/10.1016/j.jsbmb.2015.11.021DOI Listing
February 2016

The Important Roles of Steroid Sulfatase and Sulfotransferases in Gynecological Diseases.

Front Pharmacol 2016 18;7:30. Epub 2016 Feb 18.

Faculty of Medicine, Institute of Biochemistry, University of Ljubljana Ljubljana, Slovenia.

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http://dx.doi.org/10.3389/fphar.2016.00030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757672PMC
February 2016

The endometrial cancer cell lines Ishikawa and HEC-1A, and the control cell line HIEEC, differ in expression of estrogen biosynthetic and metabolic genes, and in androstenedione and estrone-sulfate metabolism.

Chem Biol Interact 2015 Jun 28;234:309-19. Epub 2014 Nov 28.

Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Slovenia. Electronic address:

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http://dx.doi.org/10.1016/j.cbi.2014.11.015DOI Listing
June 2015

Expression of AKR1B1, AKR1C3 and other genes of prostaglandin F2α biosynthesis and action in ovarian endometriosis tissue and in model cell lines.

Chem Biol Interact 2015 Jun 22;234:320-31. Epub 2014 Nov 22.

Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia. Electronic address:

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http://dx.doi.org/10.1016/j.cbi.2014.11.009DOI Listing
June 2015

Ruthenium complexes as inhibitors of the aldo-keto reductases AKR1C1-1C3.

Chem Biol Interact 2015 Jun 18;234:349-59. Epub 2014 Nov 18.

Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, SI-1000 Ljubljana, Slovenia. Electronic address:

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http://dx.doi.org/10.1016/j.cbi.2014.11.005DOI Listing
June 2015

Important roles of the AKR1C2 and SRD5A1 enzymes in progesterone metabolism in endometrial cancer model cell lines.

Chem Biol Interact 2015 Jun 23;234:297-308. Epub 2014 Nov 23.

Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia. Electronic address:

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http://dx.doi.org/10.1016/j.cbi.2014.11.012DOI Listing
June 2015

Panels of cytokines and other secretory proteins as potential biomarkers of ovarian endometriosis.

J Mol Diagn 2015 May 20;17(3):325-34. Epub 2015 Mar 20.

Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2015.01.006DOI Listing
May 2015

Diagnostic potential of peritoneal fluid biomarkers of endometriosis.

Expert Rev Mol Diagn 2015 Apr 26;15(4):557-80. Epub 2015 Feb 26.

Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia.

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http://dx.doi.org/10.1586/14737159.2015.1015994DOI Listing
April 2015

Phospholipase A2 group IIA is elevated in endometriomas but not in peritoneal fluid and serum of ovarian endometriosis patients.

Gynecol Endocrinol 2015 Mar 4;31(3):214-8. Epub 2014 Nov 4.

Institute of Biochemistry, Faculty of Medicine, University of Ljubljana , Ljubljana , Slovenia .

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http://dx.doi.org/10.3109/09513590.2014.975690DOI Listing
March 2015

The characterization of the human cell line Calu-3 under different culture conditions and its use as an optimized in vitro model to investigate bronchial epithelial function.

Eur J Pharm Sci 2015 Mar 30;69:1-9. Epub 2014 Dec 30.

Lek Pharmaceuticals, d.d., Sandoz Development Center Slovenia, Verovškova 57, 1526 Ljubljana, Slovenia. Electronic address:

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http://dx.doi.org/10.1016/j.ejps.2014.12.017DOI Listing
March 2015

Teaching the structure of immunoglobulins by molecular visualization and SDS-PAGE analysis.

Biochem Mol Biol Educ 2014 Mar-Apr;42(2):152-9. Epub 2014 Jan 21.

Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Slovenia.

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http://dx.doi.org/10.1002/bmb.20764DOI Listing
November 2014

Increased levels of biglycan in endometriomas and peritoneal fluid samples from ovarian endometriosis patients.

Gynecol Endocrinol 2014 Jul 18;30(7):520-4. Epub 2014 Mar 18.

Faculty of Medicine, Institute of Biochemistry , University of Ljubljana, Ljubljana , Slovenia and.

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http://dx.doi.org/10.3109/09513590.2014.898055DOI Listing
July 2014

Noninvasive biomarkers of endometriosis: myth or reality?

Expert Rev Mol Diagn 2014 Apr;14(3):365-85

Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia +386 1 5437 657 +386 1 5437 641

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http://dx.doi.org/10.1586/14737159.2014.899905DOI Listing
April 2014

Role of aldo-keto reductase family 1 (AKR1) enzymes in human steroid metabolism.

Steroids 2014 Jan 1;79:49-63. Epub 2013 Nov 1.

Center of Excellence in Environmental Toxicology, Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.steroids.2013.10.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870468PMC
January 2014

Estrogen biosynthesis, phase I and phase II metabolism, and action in endometrial cancer.

Mol Cell Endocrinol 2013 Dec 30;381(1-2):124-39. Epub 2013 Jul 30.

Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2013.07.026DOI Listing
December 2013

Elevated glycodelin-A concentrations in serum and peritoneal fluid of women with ovarian endometriosis.

Gynecol Endocrinol 2013 May 6;29(5):455-9. Epub 2013 Mar 6.

Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg, 2, 1000 Ljubljana, Slovenia.

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http://www.tandfonline.com/doi/full/10.3109/09513590.2013.76
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http://dx.doi.org/10.3109/09513590.2013.769516DOI Listing
May 2013

2,3-Diarylpropenoic acids as selective non-steroidal inhibitors of type-5 17β-hydroxysteroid dehydrogenase (AKR1C3).

Eur J Med Chem 2013 Apr 3;62:89-97. Epub 2013 Jan 3.

Faculty of Chemistry and Chemical Technology, University of Ljubljana, Aškerčeva 5, SI-1000 Ljubljana, Slovenia.

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http://dx.doi.org/10.1016/j.ejmech.2012.12.045DOI Listing
April 2013

Disturbed balance between phase I and II metabolizing enzymes in ovarian endometriosis: a source of excessive hydroxy-estrogens and ROS?

Mol Cell Endocrinol 2013 Mar 28;367(1-2):74-84. Epub 2012 Dec 28.

Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

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http://dx.doi.org/10.1016/j.mce.2012.12.019DOI Listing
March 2013

Correlation between erythropoietin receptor(s) and estrogen and progesterone receptor expression in different breast cancer cell lines.

Int J Mol Med 2013 Mar 8;31(3):717-25. Epub 2013 Jan 8.

Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

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https://www.spandidos-publications.com/10.3892/ijmm.2013.123
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http://dx.doi.org/10.3892/ijmm.2013.1231DOI Listing
March 2013

Decreased levels of AKR1B1 and AKR1B10 in cancerous endometrium compared to adjacent non-cancerous tissue.

Chem Biol Interact 2013 Feb 9;202(1-3):226-33. Epub 2012 Nov 9.

Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

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http://linkinghub.elsevier.com/retrieve/pii/S000927971200228
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http://dx.doi.org/10.1016/j.cbi.2012.11.001DOI Listing
February 2013

Progestin effects on expression of AKR1C1-AKR1C3, SRD5A1 and PGR in the Z-12 endometriotic epithelial cell line.

Chem Biol Interact 2013 Feb 23;202(1-3):218-25. Epub 2012 Nov 23.

Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

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http://dx.doi.org/10.1016/j.cbi.2012.10.028DOI Listing
February 2013

Altered expression of genes involved in progesterone biosynthesis, metabolism and action in endometrial cancer.

Chem Biol Interact 2013 Feb 27;202(1-3):210-7. Epub 2012 Nov 27.

Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

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http://dx.doi.org/10.1016/j.cbi.2012.11.012DOI Listing
February 2013

New enzymatic assay for the AKR1C enzymes.

Chem Biol Interact 2013 Feb 19;202(1-3):204-9. Epub 2012 Dec 19.

Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

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https://linkinghub.elsevier.com/retrieve/pii/S00092797120027
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http://dx.doi.org/10.1016/j.cbi.2012.12.003DOI Listing
February 2013

Chemico-Biological Interactions. Enzymology and molecular biology of carbonyl metabolism 16. Introduction.

Chem Biol Interact 2013 Feb;202(1-3)

Department of Biochemistry, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242-1109, USA.

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http://dx.doi.org/10.1016/j.cbi.2013.02.004DOI Listing
February 2013

Effects of progestins on local estradiol biosynthesis and action in the Z-12 endometriotic epithelial cell line.

J Steroid Biochem Mol Biol 2012 Nov 31;132(3-5):303-10. Epub 2012 Jul 31.

Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia.

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http://dx.doi.org/10.1016/j.jsbmb.2012.07.004DOI Listing
November 2012

Enzymes of the AKR1B and AKR1C Subfamilies and Uterine Diseases.

Front Pharmacol 2012 13;3:34. Epub 2012 Mar 13.

Faculty of Medicine, Institute of Biochemistry, University of Ljubljana Ljubljana, Slovenia.

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http://dx.doi.org/10.3389/fphar.2012.00034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3301985PMC
October 2012

Selective inhibitors of aldo-keto reductases AKR1C1 and AKR1C3 discovered by virtual screening of a fragment library.

J Med Chem 2012 Sep 27;55(17):7417-24. Epub 2012 Aug 27.

Institute of Biochemistry, Faculty of Medicine, University of Ljubljana , Vrazov trg 2, 1000 Ljubljana, Slovenia.

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http://pubs.acs.org/doi/10.1021/jm300841n
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http://dx.doi.org/10.1021/jm300841nDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470935PMC
September 2012

Suitability of isolated rat jejunum model for demonstration of complete absorption in humans for BCS-based biowaiver request.

J Pharm Sci 2012 Apr 10;101(4):1436-49. Epub 2012 Jan 10.

Sandoz Development Center Slovenia, Pharmaceutical and Biological Profiling, Lek Pharmaceuticals d.d., 1526 Ljubljana, Slovenia.

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http://dx.doi.org/10.1002/jps.23027DOI Listing
April 2012

Steroid-transforming enzymes in fungi.

J Steroid Biochem Mol Biol 2012 Mar 14;129(1-2):79-91. Epub 2011 Sep 14.

Institute of Biochemistry, University of Ljubljana, Ljubljana, Slovenia.

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http://dx.doi.org/10.1016/j.jsbmb.2011.08.012DOI Listing
March 2012

Steroids and microorganisms.

J Steroid Biochem Mol Biol 2012 Mar 11;129(1-2):1-3. Epub 2012 Jan 11.

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http://dx.doi.org/10.1016/j.jsbmb.2012.01.002DOI Listing
March 2012

Insights into subtle conformational differences in the substrate-binding loop of fungal 17β-hydroxysteroid dehydrogenase: a combined structural and kinetic approach.

Biochem J 2012 Jan;441(1):151-60

Istituto di Cristallografia - UOS Trieste, Consiglio Nazionale delle Ricerche, Area Science Park-Basovizza, S.S. 14 km 163.5, I-34149 Trieste, Italy.

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http://dx.doi.org/10.1042/BJ20110567DOI Listing
January 2012

Discovery of highly potent, nonsteroidal 17β-hydroxysteroid dehydrogenase type 1 inhibitors by virtual high-throughput screening.

J Steroid Biochem Mol Biol 2011 Nov 6;127(3-5):255-61. Epub 2011 Sep 6.

Faculty of Pharmacy, University of Ljubljana, Aškerčeva 7, 1000 Ljubljana, Slovenia.

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http://dx.doi.org/10.1016/j.jsbmb.2011.08.013DOI Listing
November 2011

Novel estrogen-related genes and potential biomarkers of ovarian endometriosis identified by differential expression analysis.

J Steroid Biochem Mol Biol 2011 Jul 21;125(3-5):231-42. Epub 2011 Mar 21.

Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg, 2, 1000 Ljubljana, Slovenia.

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http://dx.doi.org/10.1016/j.jsbmb.2011.03.010DOI Listing
July 2011

Novel inhibitors of trihydroxynaphthalene reductase with antifungal activity identified by ligand-based and structure-based virtual screening.

J Chem Inf Model 2011 Jul 21;51(7):1716-24. Epub 2011 Jun 21.

Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia.

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http://pubs.acs.org/doi/abs/10.1021/ci2001499
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http://dx.doi.org/10.1021/ci2001499DOI Listing
July 2011

Selectivity and potency of the retroprogesterone dydrogesterone in vitro.

Steroids 2011 May 3;76(6):607-15. Epub 2011 Mar 3.

Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia.

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http://dx.doi.org/10.1016/j.steroids.2011.02.043DOI Listing
May 2011

Disturbed expression of phase I and phase II estrogen-metabolizing enzymes in endometrial cancer: lower levels of CYP1B1 and increased expression of S-COMT.

Mol Cell Endocrinol 2011 Jan 29;331(1):158-67. Epub 2010 Sep 29.

Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia.

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http://linkinghub.elsevier.com/retrieve/pii/S030372071000472
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http://dx.doi.org/10.1016/j.mce.2010.09.011DOI Listing
January 2011

Estrogen metabolism and action in endometriosis.

Mol Cell Endocrinol 2009 Aug 8;307(1-2):8-18. Epub 2009 Apr 8.

Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

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http://dx.doi.org/10.1016/j.mce.2009.03.022DOI Listing
August 2009

New cyclopentane derivatives as inhibitors of steroid metabolizing enzymes AKR1C1 and AKR1C3.

Eur J Med Chem 2009 Jun 5;44(6):2563-71. Epub 2009 Feb 5.

Faculty of Chemistry and Chemical Technology, University of Ljubljana, Askerceva 5, 1000 Ljubljana, Slovenia.

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http://dx.doi.org/10.1016/j.ejmech.2009.01.028DOI Listing
June 2009

Disturbed estrogen and progesterone action in ovarian endometriosis.

Mol Cell Endocrinol 2009 Mar 13;301(1-2):59-64. Epub 2008 Aug 13.

Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia.

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http://dx.doi.org/10.1016/j.mce.2008.07.020DOI Listing
March 2009

Discovery of new inhibitors of aldo-keto reductase 1C1 by structure-based virtual screening.

Mol Cell Endocrinol 2009 Mar 14;301(1-2):245-50. Epub 2008 Aug 14.

Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia.

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http://dx.doi.org/10.1016/j.mce.2008.08.002DOI Listing
March 2009

Mutations that affect coenzyme binding and dimer formation of fungal 17beta-hydroxysteroid dehydrogenase.

Mol Cell Endocrinol 2009 Mar 19;301(1-2):47-50. Epub 2008 Aug 19.

Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

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http://dx.doi.org/10.1016/j.mce.2008.07.023DOI Listing
March 2009

Flavonoids and cinnamic acid derivatives as inhibitors of 17beta-hydroxysteroid dehydrogenase type 1.

Mol Cell Endocrinol 2009 Mar 17;301(1-2):229-34. Epub 2008 Sep 17.

Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia.

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http://dx.doi.org/10.1016/j.mce.2008.09.004DOI Listing
March 2009

Aberrant pre-receptor regulation of estrogen and progesterone action in endometrial cancer.

Mol Cell Endocrinol 2009 Mar 27;301(1-2):74-82. Epub 2008 Sep 27.

Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia.

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http://dx.doi.org/10.1016/j.mce.2008.09.019DOI Listing
March 2009

Two homologous fungal carbonyl reductases with different substrate specificities.

Chem Biol Interact 2009 Mar 9;178(1-3):295-302. Epub 2008 Oct 9.

Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

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http://dx.doi.org/10.1016/j.cbi.2008.09.032DOI Listing
March 2009

Simultaneous binding of coenzyme and two ligand molecules into the active site of fungal trihydroxynaphthalene reductase.

Chem Biol Interact 2009 Mar 24;178(1-3):268-73. Epub 2008 Nov 24.

Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

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http://dx.doi.org/10.1016/j.cbi.2008.11.010DOI Listing
March 2009

Towards the first inhibitors of trihydroxynaphthalene reductase from Curvularia lunata: synthesis of artificial substrate, homology modelling and initial screening.

Bioorg Med Chem 2008 Jun 29;16(11):5881-9. Epub 2008 Apr 29.

Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia.

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http://dx.doi.org/10.1016/j.bmc.2008.04.066DOI Listing
June 2008

CYP53A15 of Cochliobolus lunatus, a target for natural antifungal compounds.

J Med Chem 2008 Jun;51(12):3480-6

Lek Pharmaceuticals d d, Verovskova 57, SI-1000 Ljubljana, Slovenia.

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http://dx.doi.org/10.1021/jm800030eDOI Listing
June 2008

Pre-receptor regulation of the androgen receptor.

Mol Cell Endocrinol 2008 Jan 22;281(1-2):1-8. Epub 2007 Oct 22.

Center of Excellence in Environmental Toxicology, Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia 19104-6084, USA.

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http://dx.doi.org/10.1016/j.mce.2007.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2225387PMC
January 2008

Rational design of novel mutants of fungal 17beta-hydroxysteroid dehydrogenase.

J Biotechnol 2007 Mar 3;129(1):123-30. Epub 2006 Dec 3.

Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia.

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http://dx.doi.org/10.1016/j.jbiotec.2006.11.025DOI Listing
March 2007

New inhibitors of fungal 17beta-hydroxysteroid dehydrogenase based on the [1,5]-benzodiazepine scaffold.

J Enzyme Inhib Med Chem 2007 Feb;22(1):29-36

Faculty of Pharmacy, University of Ljubljana, Askerceva 7, 1000 Ljubljana, Slovenia.

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http://dx.doi.org/10.1080/14756360600953819DOI Listing
February 2007

Expression analysis of the genes involved in estradiol and progesterone action in human ovarian endometriosis.

Gynecol Endocrinol 2007 Feb;23(2):105-11

Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrasov trg. 2, 1000 Ljubljana, Slovenia.

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http://dx.doi.org/10.1080/09513590601152219DOI Listing
February 2007

His164 regulates accessibility to the active site in fungal 17beta-hydroxysteroid dehydrogenase.

Biochimie 2007 Jan 26;89(1):63-71. Epub 2006 Sep 26.

Institute of Biochemistry, Medical Faculty, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia.

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http://dx.doi.org/10.1016/j.biochi.2006.09.004DOI Listing
January 2007

Flavonoids and cinnamic acid esters as inhibitors of fungal 17beta-hydroxysteroid dehydrogenase: a synthesis, QSAR and modelling study.

Bioorg Med Chem 2006 Nov 7;14(22):7404-18. Epub 2006 Aug 7.

Faculty of Pharmacy, University of Ljubljana, Askerceva 7, 1000 Ljubljana, Slovenia.

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http://dx.doi.org/10.1016/j.bmc.2006.07.027DOI Listing
November 2006

Phytoestrogens as inhibitors of the human progesterone metabolizing enzyme AKR1C1.

Mol Cell Endocrinol 2006 Oct 8;259(1-2):30-42. Epub 2006 Sep 8.

Institute of Biochemistry, Medical Faculty, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia.

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http://dx.doi.org/10.1016/j.mce.2006.08.001DOI Listing
October 2006

Conformational stability of 17 beta-hydroxysteroid dehydrogenase from the fungus Cochliobolus lunatus.

FEBS J 2006 Sep;273(17):3927-37

Department of Food Science and Technology, University of Ljubljana, Slovenia.

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http://dx.doi.org/10.1111/j.1742-4658.2006.05396.xDOI Listing
September 2006

Expression analysis of estrogen-metabolizing enzymes in human endometrial cancer.

Mol Cell Endocrinol 2006 Mar 6;248(1-2):114-7. Epub 2005 Dec 6.

Institute of Biochemistry, Medical Faculty, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia.

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http://dx.doi.org/10.1016/j.mce.2005.10.013DOI Listing
March 2006

Cinnamic acids as new inhibitors of 17beta-hydroxysteroid dehydrogenase type 5 (AKR1C3).

Mol Cell Endocrinol 2006 Mar 6;248(1-2):233-5. Epub 2005 Dec 6.

Institute of Biochemistry, Medical Faculty, University of Ljubljana, 1000 Ljubljana, Slovenia.

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http://dx.doi.org/10.1016/j.mce.2005.10.020DOI Listing
March 2006

Cinnamates and cinnamamides inhibit fungal 17beta-hydroxysteroid dehydrogenase.

Mol Cell Endocrinol 2006 Mar 6;248(1-2):239-41. Epub 2005 Dec 6.

Institute of Biochemistry, Medical Faculty, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia.

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http://dx.doi.org/10.1016/j.mce.2005.10.010DOI Listing
March 2006

AKR1C1 and AKR1C3 may determine progesterone and estrogen ratios in endometrial cancer.

Mol Cell Endocrinol 2006 Mar 9;248(1-2):126-35. Epub 2005 Dec 9.

Institute of Biochemistry, Medical Faculty, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia.

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http://dx.doi.org/10.1016/j.mce.2005.10.009DOI Listing
March 2006

Nonsteroidal anti-inflammatory drugs and their analogues as inhibitors of aldo-keto reductase AKR1C3: new lead compounds for the development of anticancer agents.

Bioorg Med Chem Lett 2005 Dec 23;15(23):5170-5. Epub 2005 Sep 23.

Faculty of Pharmacy, University of Ljubljana, Slovenia.

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http://dx.doi.org/10.1016/j.bmcl.2005.08.063DOI Listing
December 2005

Dimerization and enzymatic activity of fungal 17beta-hydroxysteroid dehydrogenase from the short-chain dehydrogenase/reductase superfamily.

BMC Biochem 2005 Dec 16;6:28. Epub 2005 Dec 16.

Institute of Biochemistry, Medical Faculty, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia.

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http://dx.doi.org/10.1186/1471-2091-6-28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1326212PMC
December 2005

Crystallization, X-ray diffraction analysis and phasing of 17beta-hydroxysteroid dehydrogenase from the fungus Cochliobolus lunatus.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2005 Dec 5;61(Pt 12):1032-4. Epub 2005 Nov 5.

Institute of Crystallography, CNR, Trieste Outstation, Area Science Park-Basovizza, S.S.14, I-34012 Trieste, Italy.

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http://dx.doi.org/10.1107/S1744309105034949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1978160PMC
December 2005

Phytoestrogens as inhibitors of fungal 17beta-hydroxysteroid dehydrogenase.

Steroids 2005 Sep;70(10):694-703

Institute of Biochemistry, Medical Faculty, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia.

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http://dx.doi.org/10.1016/j.steroids.2005.02.023DOI Listing
September 2005

Coenzyme specificity in fungal 17beta-hydroxysteroid dehydrogenase.

Mol Cell Endocrinol 2005 Sep;241(1-2):80-7

Institute of Biochemistry, Medical Faculty, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia.

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http://dx.doi.org/10.1016/j.mce.2005.05.007DOI Listing
September 2005

Phytoestrogens as inhibitors of fungal 17beta-hydroxysteroid dehydrogenase.

Steroids 2005 Aug;70(9):626-35

Institute of Biochemistry, Medical Faculty, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia.

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http://dx.doi.org/10.1016/j.steroids.2005.02.022DOI Listing
August 2005

Cinnamic acid esters as potent inhibitors of fungal 17beta-hydroxysteroid dehydrogenase--a model enzyme of the short-chain dehydrogenase/reductase superfamily.

Bioorg Med Chem Lett 2004 Aug;14(15):3933-6

Faculty of Pharmacy, University of Ljubljana, Askerceva 7, 1000 Ljubljana, Slovenia.

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http://dx.doi.org/10.1016/j.bmcl.2004.05.069DOI Listing
August 2004

Evidence for 1,8-dihydroxynaphthalene melanin in three halophilic black yeasts grown under saline and non-saline conditions.

FEMS Microbiol Lett 2004 Mar;232(2):203-9

University of Ljubljana, Biotech. Faculty, Department of Biology, Vecna pot 111, SI-1000 Ljubljana, Slovenia.

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http://dx.doi.org/10.1016/S0378-1097(04)00073-4DOI Listing
March 2004

Human type 3 3alpha-hydroxysteroid dehydrogenase (aldo-keto reductase 1C2) and androgen metabolism in prostate cells.

Endocrinology 2003 Jul;144(7):2922-32

Department of Pharmacology, University of Pennsylvania School of Medicine, 3620 Hamilton Walk, Philadelphia, PA 19104-6084, USA.

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http://dx.doi.org/10.1210/en.2002-0032DOI Listing
July 2003

Significance of individual amino acid residues for coenzyme and substrate specificity of 17beta-hydroxysteroid dehydrogenase from the fungus Cochliobolus lunatus.

Chem Biol Interact 2003 Feb;143-144:493-501

Medical Faculty, Institute of Biochemistry, University of Ljubljana, Vrazov trg 2, 1000, Ljubljana, Slovenia.

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http://dx.doi.org/10.1016/s0009-2797(02)00205-3DOI Listing
February 2003

Melanin biosynthesis in the fungus Curvularia lunata (teleomorph: Cochliobolus lunatus).

Can J Microbiol 2003 Feb;49(2):110-9

Institute of Biochemistry, Medical Faculty, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia.

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http://dx.doi.org/10.1139/w03-016DOI Listing
February 2003