Publications


Coronary Artery Ectasia Predicts Future Cardiac Events in Patients With Acute Myocardial Infarction.
Arterioscler Thromb Vasc Biol 2017 Dec 19;37(12):2350-2355. Epub 2017 Oct 19.
From the Department of Cardiovascular Medicine (T.D., Y.K., T. Noguchi, T. Nakashima, S.K., K. Nakao, M.F., T. Nagai, T.K., Y.T., Y.A., T.A., K.K., Y.G., S.Y.), Department of Pediatric Cardiology (E.T.), and Department of Statistics and Data Analysis, Center for Cerebral and Cardiovascular Disease Information (M.N., K.N.), National Cerebral and Cardiovascular Center, Suita, Japan; Department of Advanced Cardiovascular Medicine (T.D., S.Y.) and Department of Cardiovascular Medicine (H.S.), Tohoku University Graduate School of Medicine, Sendai, Japan; and Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, Japan (T.S.).

Highly recurrent H3F3A mutations with additional epigenetic regulator alterations in giant cell tumor of bone.
Genes Chromosomes Cancer 2017 Oct 27;56(10):711-718. Epub 2017 Jul 27.
Division of Cancer Genomics, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.


Generation of novel patient-derived CIC- DUX4 sarcoma xenografts and cell lines.
Sci Rep 2017 Jul 5;7(1):4712. Epub 2017 Jul 5.
Department of Innovative Seeds Evaluation, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.




Genomic and transcriptomic analysis of imatinib resistance in gastrointestinal stromal tumors.
Genes Chromosomes Cancer 2017 Apr 23;56(4):303-313. Epub 2017 Jan 23.
Department of Bioinformatics, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.



Utility of Assessing the Number of Mutated KRAS, CDKN2A, TP53, and SMAD4 Genes Using a Targeted Deep Sequencing Assay as a Prognostic Biomarker for Pancreatic Cancer.
Pancreas 2017 Mar;46(3):335-340
From the *Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital, Tokyo; †Division of Genome Biology, National Cancer Center Research Institute, Tokyo; ‡Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, Sapporo; §Department of Cancer Chemotherapy, Hokkaido University Hospital Cancer Center, Sapporo; ∥Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo; Divisions of ¶Genetics and #Cancer Genomics, National Cancer Center Research Institute, Tokyo; and **Department of Hepatobiliary and Pancreatic Surgery, National Cancer Center Hospital, Tokyo, Japan.









Heat Shock Protein 90 Is a Potential Therapeutic Target in Cholangiocarcinoma.
Mol Cancer Ther 2015 Sep 3;14(9):1985-93. Epub 2015 Jul 3.
Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan. Laboratory of Molecular Medicine, Human Genome Center, The Institute of Medical Science, the University of Tokyo, Tokyo, Japan.


Prevalence, Clinical Features, and Prognosis of Acute Myocardial Infarction Attributable to Coronary Artery Embolism.
Circulation 2015 Jul 25;132(4):241-50. Epub 2015 Jun 25.
From Departments of Cardiovascular Medicine (T.S., S.K., T. Noguchi, Y.A., T.K., T. Nagai, K. Nakao, M.F., K.K., T.A., Y.G., H.O., S.Y.), Stroke and Cerebrovascular Disease (T.T., K. Nagatsuka), Pathology (H.I.-U.), and Preventive Medicine and Epidemiologic Informatics, Center for Cerebral and Cardiovascular Disease Information (K. Nishimura, Y.M.), National Cerebral and Cardiovascular Center, Suita, Japan.

Expression and clinical significance of genes frequently mutated in small cell lung cancers defined by whole exome/RNA sequencing.
Carcinogenesis 2015 Jun 11;36(6):616-21. Epub 2015 Apr 11.
Division of Genome Biology, National Cancer Center Research Institute, Tokyo 104-0045, Japan, Cancer Genome Biology Group, Institute of Predictive and Personalized Medicine of Cancer, 08916 Barcelona, Spain

Activation of the NRF2 pathway and its impact on the prognosis of anaplastic glioma patients.
Neuro Oncol 2015 Apr 10;17(4):555-65. Epub 2014 Oct 10.
Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan (M.K., Y.S., I.S., R.S., T.K., T.T.); Department of Gene Expression Regulation, Institute of Development, Aging, and Cancer, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan (T.H., S.M., M.D., H.K., K.T., H.M.); Center for Radioisotope Sciences, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan (T.H.); Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan (S.M., K.T., M.Y.); Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan (T.S.); Department of Pathology, Tohoku University Hospital, Sendai, Miyagi, Japan (M.W.); Department of Pathology and Laboratory Medicine, Sendai Medical Center, Sendai, Miyagi, Japan (H.S.); Department of Neurosurgery, Miyagi Cancer Center, Natori, Miyagi, Japan (Y.Y.).

Comprehensive DNA adduct analysis reveals pulmonary inflammatory response contributes to genotoxic action of magnetite nanoparticles.
Int J Mol Sci 2015 Feb 4;16(2):3474-92. Epub 2015 Feb 4.
Division of Carcinogenesis and Prevention, National Cancer Center Research Institute, 1-1 Tsukiji 5-chome, Chuo-ku, Tokyo 104-0045, Japan.

Translational cancer research: balancing prevention and treatment to combat cancer globally.
J Natl Cancer Inst 2015 Jan 16;107(1):353. Epub 2014 Dec 16.
Director's Office, Sections of Mechanisms of Carcinogenesis and Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France (CPW, ZH, RH, AS); National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA (JRB); Department of Pathology, Erasmus Medical Centre, Rotterdam, The Netherlands (BWDdJ); Department of Medical Epidemiology & Biostatistics, BioBanking & Molecular Resource Infrastructure, Karolinska Institute, Stockholm, Sweden (JD); Radiation Medicine Center, Karolinska Institute, Stockholm, Sweden (CvG); Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA (JDG); Department of Surgery and Cancer, Imperial College London, London, UK (EH); Danish Cancer Society Research Centre, Copenhagen, Denmark (JHO); Cancer Center Karolinska, Karolinska University Hospital Solna, Stockholm, Sweden (UR); Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan (TS); School of Public Health, University of California, Berkeley, CA, USA (MTS); Division of Preventive Oncology, National Center for Tumor Diseases and German Cancer Research Center, Heidelberg, Germany (CU); Department of Epidemiology & Biostatistics, Imperial College London, London, UK (PV); Dalla Lana School of Public Health, University of Toronto, Toronto, Canada (JM).



A novel CIC-FOXO4 gene fusion in undifferentiated small round cell sarcoma: a genetically distinct variant of Ewing-like sarcoma.
Am J Surg Pathol 2014 Nov;38(11):1571-6
Departments of *Surgical Pathology ∥Pathology ¶Orthopedic Surgery, Sapporo Medical University School of Medicine, Sapporo †Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo Departments of ‡Diagnostic Pathology §Hematology and Medical Oncology, Japan Labour Health and Welfare Organization, Kanto Rosai Hospital, Kanagawa, Japan.

Unique mutation portraits and frequent COL2A1 gene alteration in chondrosarcoma.
Genome Res 2014 Sep 14;24(9):1411-20. Epub 2014 Jul 14.
Division of Cancer Genomics, National Cancer Center Research Institute, Chuo-ku, Tokyo, 104-0045, Japan;

Wide local extension and higher proliferation indices are characteristic features of symptomatic lobular neoplasias (LNs) and LNs with an early invasive component.
Histopathology 2014 Jun 8;64(7):994-1003. Epub 2014 Mar 8.
Department of Basic Pathology, National Defence Medical College, Tokorozawa, Japan; Department of Pathology and Clinical Laboratories, National Cancer Centre Hospital, Tokyo, Japan.


Molecular mechanisms underlying oncogenic RET fusion in lung adenocarcinoma.
J Thorac Oncol 2014 May;9(5):622-30
*Division of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan; †Department of Radiation Oncology, Gunma University Graduate School of Medicine, Gunma, Japan; ‡Division of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan; §Division of Genetics, National Cancer Center Research Institute, Tokyo, Japan; and ¶Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan.

NCYM, a Cis-antisense gene of MYCN, encodes a de novo evolved protein that inhibits GSK3β resulting in the stabilization of MYCN in human neuroblastomas.
PLoS Genet 2014 Jan 2;10(1):e1003996. Epub 2014 Jan 2.
Division of Biochemistry and Innovative Cancer Therapeutics and Children's Cancer Research Center, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuo-ku, Chiba, Japan.







Induction of ZEB proteins by inactivation of RB protein is key determinant of mesenchymal phenotype of breast cancer.
J Biol Chem 2012 Mar 19;287(11):7896-906. Epub 2012 Jan 19.
Division of Gene Regulation, Institute for Advanced Medical Research, School of Medicine, Keio University, Tokyo 160-8582, Japan.




Prognostic significance of mitotic figures in metastatic mammary ductal carcinoma to the lymph nodes.
Hum Pathol 2011 Dec 17;42(12):1823-32. Epub 2011 Jun 17.
Pathology Consultation Service, Clinical Trials and Practice Support Division, Center for Cancer Control and Information Services, National Cancer Center, Chuo-ku, 104-0045, Tokyo, Japan.


Atypical tumor-stromal fibroblasts in invasive ductal carcinomas of the breast treated with neoadjuvant therapy.
Hum Pathol 2011 Jul 11;42(7):998-1006. Epub 2011 Feb 11.
Clinical Trials and Practice Support Division, Pathology Consultation Service, Center for Cancer Control and Information Services, National Cancer Center, Tokyo, 104-0045, Japan.

Cancer susceptibility polymorphism of p53 at codon 72 affects phosphorylation and degradation of p53 protein.
J Biol Chem 2011 May 28;286(20):18251-60. Epub 2011 Mar 28.
Radiobiology Division, National Cancer Center Research Institute, Tsukiji 5-1-1, Tokyo 104-0045, Japan.



MITOPLD is a mitochondrial protein essential for nuage formation and piRNA biogenesis in the mouse germline.
Dev Cell 2011 Mar;20(3):364-75
Division of Human Genetics, Department of Integrated Genetics, National Institute of Genetics, Research Organization of Information and Systems, Mishima, Shizuoka, 411-8540, Japan.









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