Tatsuhiro Shibata

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Tatsuhiro Shibata

Publications by authors named "Tatsuhiro Shibata"

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100Publications

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Molecular genomic landscapes of hepatobiliary cancer.

Cancer Sci 2018 May 28;109(5):1282-1291. Epub 2018 Apr 28.

Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan.

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May 2018

Establishment of preclinical chemotherapy models for gastroenteropancreatic neuroendocrine carcinoma.

Oncotarget 2018 Apr 20;9(30):21086-21099. Epub 2018 Apr 20.

Laboratory of Clinical Genomics, National Cancer Center Research Institute, Tokyo, Japan.

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April 2018

Whole exome sequencing to identify genetic markers for trastuzumab-induced cardiotoxicity.

Cancer Sci 2018 Feb 24;109(2):446-452. Epub 2018 Jan 24.

Division of Genetics, National Cancer Center Research Institute, Tokyo, Japan.

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February 2018

Coronary Artery Ectasia Predicts Future Cardiac Events in Patients With Acute Myocardial Infarction.

Arterioscler Thromb Vasc Biol 2017 12 19;37(12):2350-2355. Epub 2017 Oct 19.

From the Department of Cardiovascular Medicine (T.D., Y.K., T. Noguchi, T. Nakashima, S.K., K. Nakao, M.F., T. Nagai, T.K., Y.T., Y.A., T.A., K.K., Y.G., S.Y.), Department of Pediatric Cardiology (E.T.), and Department of Statistics and Data Analysis, Center for Cerebral and Cardiovascular Disease Information (M.N., K.N.), National Cerebral and Cardiovascular Center, Suita, Japan; Department of Advanced Cardiovascular Medicine (T.D., S.Y.) and Department of Cardiovascular Medicine (H.S.), Tohoku University Graduate School of Medicine, Sendai, Japan; and Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, Japan (T.S.).

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December 2017

Highly recurrent H3F3A mutations with additional epigenetic regulator alterations in giant cell tumor of bone.

Genes Chromosomes Cancer 2017 10 27;56(10):711-718. Epub 2017 Jul 27.

Division of Cancer Genomics, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

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October 2017

Clinical Utility of Circulating Tumor DNA for Molecular Assessment and Precision Medicine in Pancreatic Cancer.

Adv Exp Med Biol 2016 ;924:13-17

Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan.

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September 2017

NUTM2A-CIC fusion small round cell sarcoma: a genetically distinct variant of CIC-rearranged sarcoma.

Hum Pathol 2017 07 8;65:225-230. Epub 2017 Feb 8.

Department of Surgical Pathology, Sapporo Medical University, School of Medicine, Sapporo, Hokkaido 060-8543, Japan. Electronic address:

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July 2017

Generation of novel patient-derived CIC- DUX4 sarcoma xenografts and cell lines.

Sci Rep 2017 Jul 5;7(1):4712. Epub 2017 Jul 5.

Department of Innovative Seeds Evaluation, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

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July 2017

The Induction of Selected Wnt Target Genes by Tcf1 Mediates Generation of Tumorigenic Colon Stem Cells.

Cell Rep 2017 05;19(5):981-994

Division of Cancer Differentiation, National Cancer Center Research Institute, Chuo-ku, Tokyo 104-0045, Japan. Electronic address:

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May 2017

Genomic and transcriptomic analysis of imatinib resistance in gastrointestinal stromal tumors.

Genes Chromosomes Cancer 2017 04 23;56(4):303-313. Epub 2017 Jan 23.

Department of Bioinformatics, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

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April 2017

Utility of Assessing the Number of Mutated KRAS, CDKN2A, TP53, and SMAD4 Genes Using a Targeted Deep Sequencing Assay as a Prognostic Biomarker for Pancreatic Cancer.

Pancreas 2017 03;46(3):335-340

From the *Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital, Tokyo; †Division of Genome Biology, National Cancer Center Research Institute, Tokyo; ‡Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, Sapporo; §Department of Cancer Chemotherapy, Hokkaido University Hospital Cancer Center, Sapporo; ∥Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo; Divisions of ¶Genetics and #Cancer Genomics, National Cancer Center Research Institute, Tokyo; and **Department of Hepatobiliary and Pancreatic Surgery, National Cancer Center Hospital, Tokyo, Japan.

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March 2017

Establishment of various biliary tract carcinoma cell lines and xenograft models for appropriate preclinical studies.

World J Gastroenterol 2016 Oct;22(40):9035-9038

Hidenori Ojima, Division of Molecular Pathology, National Cancer Center Research Institute, Tokyo 104-0045, Japan.

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October 2016

Profiling of actionable gene alterations in ovarian cancer by targeted deep sequencing.

Int J Oncol 2015 3;46(6):2389-98. Epub 2015 Apr 3.

Division of Genome Biology, National Cancer Center Research Institute, Tokyo 104-0045, Japan.

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January 2016

Current and future molecular profiling of cancer by next-generation sequencing.

Jpn J Clin Oncol 2015 Oct 19;45(10):895-9. Epub 2015 Aug 19.

Laboratory of Molecular Medicine, Institute of Medical Science, University of Tokyo, Tokyo Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan

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October 2015

SRY and OCT4 Are Required for the Acquisition of Cancer Stem Cell-Like Properties and Are Potential Differentiation Therapy Targets.

Stem Cells 2015 Sep 23;33(9):2652-63. Epub 2015 Jun 23.

Department of Biological Sciences and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, Niijuku, Katsushika-ku, Tokyo, Japan.

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September 2015

Heat Shock Protein 90 Is a Potential Therapeutic Target in Cholangiocarcinoma.

Mol Cancer Ther 2015 Sep 3;14(9):1985-93. Epub 2015 Jul 3.

Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan. Laboratory of Molecular Medicine, Human Genome Center, The Institute of Medical Science, the University of Tokyo, Tokyo, Japan.

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September 2015

Prevalence, Clinical Features, and Prognosis of Acute Myocardial Infarction Attributable to Coronary Artery Embolism.

Circulation 2015 Jul 25;132(4):241-50. Epub 2015 Jun 25.

From Departments of Cardiovascular Medicine (T.S., S.K., T. Noguchi, Y.A., T.K., T. Nagai, K. Nakao, M.F., K.K., T.A., Y.G., H.O., S.Y.), Stroke and Cerebrovascular Disease (T.T., K. Nagatsuka), Pathology (H.I.-U.), and Preventive Medicine and Epidemiologic Informatics, Center for Cerebral and Cardiovascular Disease Information (K. Nishimura, Y.M.), National Cerebral and Cardiovascular Center, Suita, Japan.

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July 2015

Expression and clinical significance of genes frequently mutated in small cell lung cancers defined by whole exome/RNA sequencing.

Carcinogenesis 2015 Jun 11;36(6):616-21. Epub 2015 Apr 11.

Division of Genome Biology, National Cancer Center Research Institute, Tokyo 104-0045, Japan, Cancer Genome Biology Group, Institute of Predictive and Personalized Medicine of Cancer, 08916 Barcelona, Spain

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June 2015

Activation of the NRF2 pathway and its impact on the prognosis of anaplastic glioma patients.

Neuro Oncol 2015 Apr 10;17(4):555-65. Epub 2014 Oct 10.

Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan (M.K., Y.S., I.S., R.S., T.K., T.T.); Department of Gene Expression Regulation, Institute of Development, Aging, and Cancer, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan (T.H., S.M., M.D., H.K., K.T., H.M.); Center for Radioisotope Sciences, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan (T.H.); Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan (S.M., K.T., M.Y.); Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan (T.S.); Department of Pathology, Tohoku University Hospital, Sendai, Miyagi, Japan (M.W.); Department of Pathology and Laboratory Medicine, Sendai Medical Center, Sendai, Miyagi, Japan (H.S.); Department of Neurosurgery, Miyagi Cancer Center, Natori, Miyagi, Japan (Y.Y.).

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April 2015

Comprehensive DNA adduct analysis reveals pulmonary inflammatory response contributes to genotoxic action of magnetite nanoparticles.

Int J Mol Sci 2015 Feb 4;16(2):3474-92. Epub 2015 Feb 4.

Division of Carcinogenesis and Prevention, National Cancer Center Research Institute, 1-1 Tsukiji 5-chome, Chuo-ku, Tokyo 104-0045, Japan.

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February 2015

Translational cancer research: balancing prevention and treatment to combat cancer globally.

J Natl Cancer Inst 2015 Jan 16;107(1):353. Epub 2014 Dec 16.

Director's Office, Sections of Mechanisms of Carcinogenesis and Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France (CPW, ZH, RH, AS); National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA (JRB); Department of Pathology, Erasmus Medical Centre, Rotterdam, The Netherlands (BWDdJ); Department of Medical Epidemiology & Biostatistics, BioBanking & Molecular Resource Infrastructure, Karolinska Institute, Stockholm, Sweden (JD); Radiation Medicine Center, Karolinska Institute, Stockholm, Sweden (CvG); Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA (JDG); Department of Surgery and Cancer, Imperial College London, London, UK (EH); Danish Cancer Society Research Centre, Copenhagen, Denmark (JHO); Cancer Center Karolinska, Karolinska University Hospital Solna, Stockholm, Sweden (UR); Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan (TS); School of Public Health, University of California, Berkeley, CA, USA (MTS); Division of Preventive Oncology, National Center for Tumor Diseases and German Cancer Research Center, Heidelberg, Germany (CU); Department of Epidemiology & Biostatistics, Imperial College London, London, UK (PV); Dalla Lana School of Public Health, University of Toronto, Toronto, Canada (JM).

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January 2015

A novel CIC-FOXO4 gene fusion in undifferentiated small round cell sarcoma: a genetically distinct variant of Ewing-like sarcoma.

Am J Surg Pathol 2014 Nov;38(11):1571-6

Departments of *Surgical Pathology ∥Pathology ¶Orthopedic Surgery, Sapporo Medical University School of Medicine, Sapporo †Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo Departments of ‡Diagnostic Pathology §Hematology and Medical Oncology, Japan Labour Health and Welfare Organization, Kanto Rosai Hospital, Kanagawa, Japan.

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November 2014

Unique mutation portraits and frequent COL2A1 gene alteration in chondrosarcoma.

Genome Res 2014 Sep 14;24(9):1411-20. Epub 2014 Jul 14.

Division of Cancer Genomics, National Cancer Center Research Institute, Chuo-ku, Tokyo, 104-0045, Japan;

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September 2014

A human cancer xenograft model utilizing normal pancreatic duct epithelial cells conditionally transformed with defined oncogenes.

Carcinogenesis 2014 Aug 24;35(8):1840-6. Epub 2014 May 24.

Division of Virology, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan,

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August 2014

Wide local extension and higher proliferation indices are characteristic features of symptomatic lobular neoplasias (LNs) and LNs with an early invasive component.

Histopathology 2014 Jun 8;64(7):994-1003. Epub 2014 Mar 8.

Department of Basic Pathology, National Defence Medical College, Tokorozawa, Japan; Department of Pathology and Clinical Laboratories, National Cancer Centre Hospital, Tokyo, Japan.

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June 2014

Exploration of liver cancer genomes.

Nat Rev Gastroenterol Hepatol 2014 Jun 28;11(6):340-9. Epub 2014 Jan 28.

Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1, Komaba, Meguro-ku, Tokyo 153-8904, Japan.

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June 2014

Axitinib (AG-013736), an oral specific VEGFR TKI, shows potential therapeutic utility against cholangiocarcinoma.

Jpn J Clin Oncol 2014 Jun 21;44(6):570-8. Epub 2014 Apr 21.

Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo

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June 2014

Immunohistochemical detection of ROS1 is useful for identifying ROS1 rearrangements in lung cancers.

Mod Pathol 2014 May 1;27(5):711-20. Epub 2013 Nov 1.

Division of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan.

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May 2014

Involvement of telomerase reverse transcriptase in heterochromatin maintenance.

Mol Cell Biol 2014 May 18;34(9):1576-93. Epub 2014 Feb 18.

Division of Cancer Stem Cell, National Cancer Center Research Institute, Tokyo, Japan.

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May 2014

Molecular mechanisms underlying oncogenic RET fusion in lung adenocarcinoma.

J Thorac Oncol 2014 May;9(5):622-30

*Division of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan; †Department of Radiation Oncology, Gunma University Graduate School of Medicine, Gunma, Japan; ‡Division of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan; §Division of Genetics, National Cancer Center Research Institute, Tokyo, Japan; and ¶Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan.

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May 2014

Emerging drugs for biliary cancer.

Expert Opin Emerg Drugs 2014 Mar 20;19(1):11-24. Epub 2013 Dec 20.

National Cancer Center Hospital, Department of Hepatobiliary and Pancreatic Oncology , 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 , Japan +81 3 3542 2511 ; +81 3 3542 3815 ;

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March 2014

Inflammatory myofibroblastic tumour of the lung with a novel PPFIBP1-ALK fusion variant.

Histopathology 2013 Dec 19;63(6):881-3. Epub 2013 Aug 19.

Division of Pathology and Clinical Laboratories, National Cancer Centre Hospital, Tokyo, Japan.

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December 2013

Comprehensive genome sequencing of the liver cancer genome.

Cancer Lett 2013 Nov 8;340(2):234-40. Epub 2012 Nov 8.

Center for Genomic Medicine, RIKEN, Yokohama, Japan. Electronic address:

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November 2013

Genome-wide identification of genes with amplification and/or fusion in small cell lung cancer.

Genes Chromosomes Cancer 2013 Sep 28;52(9):802-16. Epub 2013 May 28.

Division of Multistep Carcinogenesis, National Cancer Center Research Institute, Tokyo 104-0045, Japan.

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September 2013

Histological factors for accurately predicting first locoregional recurrence of invasive ductal carcinoma of the breast.

Cancer Sci 2013 Sep 25;104(9):1252-61. Epub 2013 Jul 25.

Diagnostic Pathology Section, Medical Support and Partnership Division, Center for Cancer Control and Information Services, National Cancer Center, Tokyo, Japan.

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September 2013

Mouse model for ROS1-rearranged lung cancer.

PLoS One 2013 13;8(2):e56010. Epub 2013 Feb 13.

Division of Cancer Genomics, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.

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August 2013

Aberrant anaplastic lymphoma kinase expression in high-grade pulmonary neuroendocrine carcinoma.

J Clin Pathol 2013 Aug 25;66(8):705-7. Epub 2013 Apr 25.

Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan.

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August 2013

Anaplastic lymphoma kinase status in rhabdomyosarcomas.

Mod Pathol 2013 Jun 11;26(6):772-81. Epub 2013 Jan 11.

Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan.

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June 2013

Regulatory nexus of synthesis and degradation deciphers cellular Nrf2 expression levels.

Mol Cell Biol 2013 Jun 9;33(12):2402-12. Epub 2013 Apr 9.

Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.

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June 2013

ROS1-rearranged lung cancer: a clinicopathologic and molecular study of 15 surgical cases.

Am J Surg Pathol 2013 Apr;37(4):554-62

Division of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan.

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April 2013

Cancer genomics and pathology: all together now.

Pathol Int 2012 Oct;62(10):647-59

Division of Cancer Genomics, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.

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October 2012

Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming.

Cancer Cell 2012 Jul;22(1):66-79

Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575, Japan.

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July 2012

Induction of ZEB proteins by inactivation of RB protein is key determinant of mesenchymal phenotype of breast cancer.

J Biol Chem 2012 Mar 19;287(11):7896-906. Epub 2012 Jan 19.

Division of Gene Regulation, Institute for Advanced Medical Research, School of Medicine, Keio University, Tokyo 160-8582, Japan.

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March 2012

MDM2 and CDK4 immunohistochemical coexpression in high-grade osteosarcoma: correlation with a dedifferentiated subtype.

Am J Surg Pathol 2012 Mar;36(3):423-31

Departments of Pathology and Clinical Laboratories, National Cancer Center Research Institute, Tokyo, Japan.

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March 2012

Prognostic significance of mitotic figures in metastatic mammary ductal carcinoma to the lymph nodes.

Hum Pathol 2011 Dec 17;42(12):1823-32. Epub 2011 Jun 17.

Pathology Consultation Service, Clinical Trials and Practice Support Division, Center for Cancer Control and Information Services, National Cancer Center, Chuo-ku, 104-0045, Tokyo, Japan.

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December 2011

Maintenance of tumor initiating cells of defined genetic composition by nucleostemin.

Proc Natl Acad Sci U S A 2011 Dec 5;108(51):20388-93. Epub 2011 Jul 5.

Division of Cancer Stem Cell, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.

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December 2011

Important histologic outcome predictors for patients with invasive ductal carcinoma of the breast.

Am J Surg Pathol 2011 Oct;35(10):1484-97

Pathology Consultation Service, Clinical Trials and Practice Support Division, Center for Cancer Control and Information Services, National Cancer Center Hospital, Tokyo, Japan.

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October 2011

Comprehensive histologic analysis of ALK-rearranged lung carcinomas.

Am J Surg Pathol 2011 Aug;35(8):1226-34

Pathology and Clinical Laboratory Division, National Cancer Center Hospital, Tokyo, Japan.

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August 2011