Tatsuhiko Tsunoda

Tatsuhiko Tsunoda

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Tatsuhiko Tsunoda

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Brain wave classification using long short-term memory network based OPTICAL predictor.

Sci Rep 2019 Jun 24;9(1):9153. Epub 2019 Jun 24.

Department of Medical Science Mathematics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.

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http://dx.doi.org/10.1038/s41598-019-45605-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591300PMC
June 2019

HseSUMO: Sumoylation site prediction using half-sphere exposures of amino acids residues.

BMC Genomics 2019 Apr 18;19(Suppl 9):982. Epub 2019 Apr 18.

Laboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan.

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http://dx.doi.org/10.1186/s12864-018-5206-8DOI Listing
April 2019

Navigating the disease landscape: knowledge representations for contextualizing molecular signatures.

Brief Bioinform 2019 Mar;20(2):609-623

Charles Auffray European Institute for Systems Biology and Medicine, Lyon, France.

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http://dx.doi.org/10.1093/bib/bby025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556902PMC
March 2019

OPAL+: Length-Specific MoRF Prediction in Intrinsically Disordered Protein Sequences.

Proteomics 2019 Mar 2;19(6):e1800058. Epub 2018 Nov 2.

Human Genome Center, The Institute of Medical Science, The University of Tokyo, Tokyo, 108-8639, Japan.

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http://dx.doi.org/10.1002/pmic.201800058DOI Listing
March 2019

Discovering MoRFs by trisecting intrinsically disordered protein sequence into terminals and middle regions.

BMC Bioinformatics 2019 Feb 4;19(Suppl 13):378. Epub 2019 Feb 4.

Laboratory of Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.

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http://dx.doi.org/10.1186/s12859-018-2396-7DOI Listing
February 2019

Exploring predictive biomarkers from clinical genome-wide association studies via multidimensional hierarchical mixture models.

Eur J Hum Genet 2019 01 10;27(1):140-149. Epub 2018 Sep 10.

Department of Medical Science Mathematics, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan.

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http://www.nature.com/articles/s41431-018-0251-y
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http://dx.doi.org/10.1038/s41431-018-0251-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303260PMC
January 2019

An integrative machine learning approach for prediction of toxicity-related drug safety.

Life Sci Alliance 2018 Dec 28;1(6):e201800098. Epub 2018 Nov 28.

Laboratory for Medical Science Mathematics, Rikagaku Kenkyūjyo Center for Integrative Medical Sciences, Tsurumi, Japan.

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http://dx.doi.org/10.26508/lsa.201800098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262234PMC
December 2018

SumSec: Accurate Prediction of Sumoylation Sites Using Predicted Secondary Structure.

Molecules 2018 Dec 10;23(12). Epub 2018 Dec 10.

Laboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan.

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http://dx.doi.org/10.3390/molecules23123260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320791PMC
December 2018

PhoglyStruct: Prediction of phosphoglycerylated lysine residues using structural properties of amino acids.

Sci Rep 2018 Dec 18;8(1):17923. Epub 2018 Dec 18.

Department of Medical Science Mathematics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, 113-8510, Japan.

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http://dx.doi.org/10.1038/s41598-018-36203-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299098PMC
December 2018

Gene expression dataset for whole cochlea of Macaca fascicularis.

Sci Rep 2018 Oct 22;8(1):15554. Epub 2018 Oct 22.

Division Hearing and Balance Research, National Institute of Sensory Organs, National Hospital Organization Tokyo Medical Center, 2-5-1 Higashigaoka, Meguro-ku, Tokyo, 152-8902, Japan.

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http://www.nature.com/articles/s41598-018-33985-9
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http://dx.doi.org/10.1038/s41598-018-33985-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197234PMC
October 2018

A novel homozygous missense mutation in the SH3-binding motif of STAMBP causing microcephaly-capillary malformation syndrome.

J Hum Genet 2018 Sep 15;63(9):957-963. Epub 2018 Jun 15.

Department of Pediatrics and Neonatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

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http://dx.doi.org/10.1038/s10038-018-0482-3DOI Listing
September 2018

Structure-activity relationship of clovamide and its related compounds for the inhibition of amyloid β aggregation.

Bioorg Med Chem 2018 07 22;26(12):3202-3209. Epub 2018 Apr 22.

Faculty of Life and Environmental Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8572, Japan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09680896183066
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http://dx.doi.org/10.1016/j.bmc.2018.04.044DOI Listing
July 2018

OPAL: prediction of MoRF regions in intrinsically disordered protein sequences.

Bioinformatics 2018 06;34(11):1850-1858

School of Engineering and Physics, The University of the South Pacific, Suva, Fiji.

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https://academic.oup.com/bioinformatics/article/34/11/1850/4
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http://dx.doi.org/10.1093/bioinformatics/bty032DOI Listing
June 2018

MoRFPred-plus: Computational Identification of MoRFs in Protein Sequences using Physicochemical Properties and HMM profiles.

J Theor Biol 2018 01 16;437:9-16. Epub 2017 Oct 16.

Department of Engineering and Physics, the University of the South Pacific, Suva, Fiji; CREST, JST, Yokohama 230-0045, Japan; RIKEN Center for Integrative Medical Science, Yokohama 230-0045, Japan; Griffith University, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.jtbi.2017.10.015DOI Listing
January 2018

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.

Authors:
Florence Demenais Patricia Margaritte-Jeannin Kathleen C Barnes William O C Cookson Janine Altmüller Wei Ang R Graham Barr Terri H Beaty Allan B Becker John Beilby Hans Bisgaard Unnur Steina Bjornsdottir Eugene Bleecker Klaus Bønnelykke Dorret I Boomsma Emmanuelle Bouzigon Christopher E Brightling Myriam Brossard Guy G Brusselle Esteban Burchard Kristin M Burkart Andrew Bush Moira Chan-Yeung Kian Fan Chung Alexessander Couto Alves John A Curtin Adnan Custovic Denise Daley Johan C de Jongste Blanca E Del-Rio-Navarro Kathleen M Donohue Liesbeth Duijts Celeste Eng Johan G Eriksson Martin Farrall Yuliya Fedorova Bjarke Feenstra Manuel A Ferreira Maxim B Freidin Zofia Gajdos Jim Gauderman Ulrike Gehring Frank Geller Jon Genuneit Sina A Gharib Frank Gilliland Raquel Granell Penelope E Graves Daniel F Gudbjartsson Tari Haahtela Susan R Heckbert Dick Heederik Joachim Heinrich Markku Heliövaara John Henderson Blanca E Himes Hiroshi Hirose Joel N Hirschhorn Albert Hofman Patrick Holt Jouke Hottenga Thomas J Hudson Jennie Hui Medea Imboden Vladimir Ivanov Vincent W V Jaddoe Alan James Christer Janson Marjo-Riitta Jarvelin Deborah Jarvis Graham Jones Ingileif Jonsdottir Pekka Jousilahti Michael Kabesch Mika Kähönen David B Kantor Alexandra S Karunas Elza Khusnutdinova Gerard H Koppelman Anita L Kozyrskyj Eskil Kreiner Michiaki Kubo Rajesh Kumar Ashish Kumar Mikko Kuokkanen Lies Lahousse Tarja Laitinen Catherine Laprise Mark Lathrop Susanne Lau Young-Ae Lee Terho Lehtimäki Sébastien Letort Albert M Levin Guo Li Liming Liang Laura R Loehr Stephanie J London Daan W Loth Ani Manichaikul Ingo Marenholz Fernando J Martinez Melanie C Matheson Rasika A Mathias Kenji Matsumoto Hamdi Mbarek Wendy L McArdle Mads Melbye Erik Melén Deborah Meyers Sven Michel Hamida Mohamdi Arthur W Musk Rachel A Myers Maartje A E Nieuwenhuis Emiko Noguchi George T O'Connor Ludmila M Ogorodova Cameron D Palmer Aarno Palotie Julie E Park Craig E Pennell Göran Pershagen Alexey Polonikov Dirkje S Postma Nicole Probst-Hensch Valery P Puzyrev Benjamin A Raby Olli T Raitakari Adaikalavan Ramasamy Stephen S Rich Colin F Robertson Isabelle Romieu Muhammad T Salam Veikko Salomaa Vivi Schlünssen Robert Scott Polina A Selivanova Torben Sigsgaard Angela Simpson Valérie Siroux Lewis J Smith Maria Solodilova Marie Standl Kari Stefansson David P Strachan Bruno H Stricker Atsushi Takahashi Philip J Thompson Gudmar Thorleifsson Unnur Thorsteinsdottir Carla M T Tiesler Dara G Torgerson Tatsuhiko Tsunoda André G Uitterlinden Ralf J P van der Valk Amaury Vaysse Sailaja Vedantam Andrea von Berg Erika von Mutius Judith M Vonk Johannes Waage Nick J Wareham Scott T Weiss Wendy B White Magnus Wickman Elisabeth Widén Gonneke Willemsen L Keoki Williams Inge M Wouters James J Yang Jing Hua Zhao Miriam F Moffatt Carole Ober Dan L Nicolae

Nat Genet 2018 01 22;50(1):42-53. Epub 2017 Dec 22.

Departments of Statistics, Human Genetics and Medicine, Section of Genetic Medicine, University of Chicago, Chicago, IL, USA.

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http://www.nature.com/articles/s41588-017-0014-7
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http://dx.doi.org/10.1038/s41588-017-0014-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901974PMC
January 2018

Success: evolutionary and structural properties of amino acids prove effective for succinylation site prediction.

BMC Genomics 2018 01 19;19(Suppl 1):923. Epub 2018 Jan 19.

Department of Medical Science Mathematics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.

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http://dx.doi.org/10.1186/s12864-017-4336-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5781056PMC
January 2018

Divisive hierarchical maximum likelihood clustering.

BMC Bioinformatics 2017 12 28;18(Suppl 16):546. Epub 2017 Dec 28.

Laboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, 230-0045, Japan.

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http://dx.doi.org/10.1186/s12859-017-1965-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751574PMC
December 2017

2D-EM clustering approach for high-dimensional data through folding feature vectors.

BMC Bioinformatics 2017 12 28;18(Suppl 16):547. Epub 2017 Dec 28.

Center for Integrative Medical Sciences, RIKEN Yokohama, Yokohama, 230-0045, Japan.

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http://dx.doi.org/10.1186/s12859-017-1970-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751765PMC
December 2017

An improved discriminative filter bank selection approach for motor imagery EEG signal classification using mutual information.

BMC Bioinformatics 2017 12 28;18(Suppl 16):545. Epub 2017 Dec 28.

RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.

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http://dx.doi.org/10.1186/s12859-017-1964-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751568PMC
December 2017

Siblings with optic neuropathy and RTN4IP1 mutation.

J Hum Genet 2017 Oct 22;62(10):927-929. Epub 2017 Jun 22.

Center for Medical Genetics, Keio University School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1038/jhg.2017.68DOI Listing
October 2017

A novel genetic syndrome with STARD9 mutation and abnormal spindle morphology.

Am J Med Genet A 2017 Oct 4;173(10):2690-2696. Epub 2017 Aug 4.

National Institute of Genetics, Department of Molecular Genetics, Division of Centrosome Biology, Mishima, Shizuoka, Japan.

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http://dx.doi.org/10.1002/ajmg.a.38391DOI Listing
October 2017

A novel missense mutation in the HECT domain of NEDD4L identified in a girl with periventricular nodular heterotopia, polymicrogyria and cleft palate.

J Hum Genet 2017 Sep 18;62(9):861-863. Epub 2017 May 18.

Department of Pediatrics and Neonatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

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http://dx.doi.org/10.1038/jhg.2017.53DOI Listing
September 2017

PSSM-Suc: Accurately predicting succinylation using position specific scoring matrix into bigram for feature extraction.

J Theor Biol 2017 07 5;425:97-102. Epub 2017 May 5.

Laboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan; Institute for Integrated and Intelligent Systems, Griffith University, Australia; School of Engineering & Physics, University of the South Pacific, Fiji.

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http://dx.doi.org/10.1016/j.jtbi.2017.05.005DOI Listing
July 2017

The prediction models for postoperative overall survival and disease-free survival in patients with breast cancer.

Cancer Med 2017 Jul 24;6(7):1627-1638. Epub 2017 May 24.

Department of Medical Science Mathematics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.

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http://dx.doi.org/10.1002/cam4.1092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504310PMC
July 2017

Arete - candidate gene prioritization using biological network topology with additional evidence types.

BioData Min 2017 6;10:22. Epub 2017 Jul 6.

Laboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi, Yokohama, 230-0045 Japan.

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http://dx.doi.org/10.1186/s13040-017-0141-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501438PMC
July 2017

SucStruct: Prediction of succinylated lysine residues by using structural properties of amino acids.

Anal Biochem 2017 06 28;527:24-32. Epub 2017 Mar 28.

Laboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan; Institute for Integrated and Intelligent Systems, Griffith University, Australia.

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http://dx.doi.org/10.1016/j.ab.2017.03.021DOI Listing
June 2017

Novel MCA/ID syndrome with ASH1L mutation.

Am J Med Genet A 2017 Jun 10;173(6):1644-1648. Epub 2017 Apr 10.

Center for Medical Genetics, Keio University School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1002/ajmg.a.38193DOI Listing
June 2017

Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels.

Authors:
Cassandra N Spracklen Peng Chen Young Jin Kim Xu Wang Hui Cai Shengxu Li Jirong Long Ying Wu Ya Xing Wang Fumihiko Takeuchi Jer-Yuarn Wu Keum-Ji Jung Cheng Hu Koichi Akiyama Yonghong Zhang Sanghoon Moon Todd A Johnson Huaixing Li Rajkumar Dorajoo Meian He Maren E Cannon Tamara S Roman Elias Salfati Keng-Hung Lin Xiuqing Guo Wayne H H Sheu Devin Absher Linda S Adair Themistocles L Assimes Tin Aung Qiuyin Cai Li-Ching Chang Chien-Hsiun Chen Li-Hsin Chien Lee-Ming Chuang Shu-Chun Chuang Shufa Du Qiao Fan Cathy S J Fann Alan B Feranil Yechiel Friedlander Penny Gordon-Larsen Dongfeng Gu Lixuan Gui Zhirong Guo Chew-Kiat Heng James Hixson Xuhong Hou Chao Agnes Hsiung Yao Hu Mi Yeong Hwang Chii-Min Hwu Masato Isono Jyh-Ming Jimmy Juang Chiea-Chuen Khor Yun Kyoung Kim Woon-Puay Koh Michiaki Kubo I-Te Lee Sun-Ju Lee Wen-Jane Lee Kae-Woei Liang Blanche Lim Sing-Hui Lim Jianjun Liu Toru Nabika Wen-Harn Pan Hao Peng Thomas Quertermous Charumathi Sabanayagam Kevin Sandow Jinxiu Shi Liang Sun Pok Chien Tan Shu-Pei Tan Kent D Taylor Yik-Ying Teo Sue-Anne Toh Tatsuhiko Tsunoda Rob M van Dam Aili Wang Feijie Wang Jie Wang Wen Bin Wei Yong-Bing Xiang Jie Yao Jian-Min Yuan Rong Zhang Wanting Zhao Yii-Der Ida Chen Stephen S Rich Jerome I Rotter Tzung-Dau Wang Tangchun Wu Xu Lin Bok-Ghee Han Toshihiro Tanaka Yoon Shin Cho Tomohiro Katsuya Weiping Jia Sun-Ha Jee Yuan-Tsong Chen Norihiro Kato Jost B Jonas Ching-Yu Cheng Xiao-Ou Shu Jiang He Wei Zheng Tien-Yin Wong Wei Huang Bong-Jo Kim E-Shyong Tai Karen L Mohlke Xueling Sim

Hum Mol Genet 2017 05;26(9):1770-1784

Saw Swee Hock School of Public Health, National University Health System, National University of Singapore, Singapore, Singapore.

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http://dx.doi.org/10.1093/hmg/ddx062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075203PMC
May 2017

Identification of a Human Clonogenic Progenitor with Strict Monocyte Differentiation Potential: A Counterpart of Mouse cMoPs.

Immunity 2017 05;46(5):835-848.e4

Department of Biodefense Research, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113-8510, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2017.04.019DOI Listing
May 2017

Hierarchical Maximum Likelihood Clustering Approach.

IEEE Trans Biomed Eng 2017 01 24;64(1):112-122. Epub 2016 Mar 24.

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http://dx.doi.org/10.1109/TBME.2016.2542212DOI Listing
January 2017

Predicting MoRFs in protein sequences using HMM profiles.

BMC Bioinformatics 2016 Dec 22;17(Suppl 19):504. Epub 2016 Dec 22.

School of Engineering and Physics, The University of the South Pacific, Suva, Fiji.

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http://dx.doi.org/10.1186/s12859-016-1375-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5259822PMC
December 2016

ALDH18A1-related cutis laxa syndrome with cyclic vomiting.

Brain Dev 2016 Aug 29;38(7):678-84. Epub 2016 Jan 29.

Department of Pediatrics, Shiga Medical Center for Children, Shiga, Japan.

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http://dx.doi.org/10.1016/j.braindev.2016.01.003DOI Listing
August 2016

Stepwise iterative maximum likelihood clustering approach.

BMC Bioinformatics 2016 Aug 24;17(1):319. Epub 2016 Aug 24.

RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.

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http://dx.doi.org/10.1186/s12859-016-1184-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995791PMC
August 2016

Novel splicing mutation in the ASXL3 gene causing Bainbridge-Ropers syndrome.

Am J Med Genet A 2016 07 13;170(7):1863-7. Epub 2016 Apr 13.

Department of Pediatrics and Neonatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

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http://dx.doi.org/10.1002/ajmg.a.37653DOI Listing
July 2016

A functional SNP in FLT1 increases risk of coronary artery disease in a Japanese population.

J Hum Genet 2016 May 21;61(5):435-41. Epub 2016 Jan 21.

Laboratory for Cardiovascular Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.

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http://dx.doi.org/10.1038/jhg.2015.171DOI Listing
May 2016

Systematic analysis of mutation distribution in three dimensional protein structures identifies cancer driver genes.

Sci Rep 2016 05 26;6:26483. Epub 2016 May 26.

Laboratory for Genome Sequencing Analysis, RIKEN Center for Integrative Medical Sciences, Japan.

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http://dx.doi.org/10.1038/srep26483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880911PMC
May 2016

Truncating mutation in NFIA causes brain malformation and urinary tract defects.

Hum Genome Var 2015 26;2:15007. Epub 2015 Feb 26.

Department of Pediatrics and Neonatology, Nagoya City University Graduate School of Medical Sciences , Nagoya, Japan.

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http://dx.doi.org/10.1038/hgv.2015.7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785547PMC
April 2016

Attenuation of progressive hearing loss in DBA/2J mice by reagents that affect epigenetic modifications is associated with up-regulation of the zinc importer Zip4.

PLoS One 2015 14;10(4):e0124301. Epub 2015 Apr 14.

Laboratory of Auditory Disorders, Division of Balance and Hearing Research, National Institute of Sensory Organs, National Tokyo Medical Center, Meguro, Tokyo, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0124301PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397065PMC
April 2016

Exome Analyses of Long QT Syndrome Reveal Candidate Pathogenic Mutations in Calmodulin-Interacting Genes.

PLoS One 2015 1;10(7):e0130329. Epub 2015 Jul 1.

Laboratory for Cardiovascular Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Department of Human Genetics and Disease Diversity, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, Tokyo, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0130329PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488844PMC
April 2016

Protein fold recognition using HMM-HMM alignment and dynamic programming.

J Theor Biol 2016 Mar 19;393:67-74. Epub 2016 Jan 19.

Laboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi, Yokohama 230-0045, Japan; Institute of Integrated and Intelligent Systems, Griffith University, Brisbane, Australia; School of Engineering and Physics, University of the South Pacific, Fiji. Electronic address:

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http://dx.doi.org/10.1016/j.jtbi.2015.12.018DOI Listing
March 2016

The subcellular localization and activity of cortactin is regulated by acetylation and interaction with Keap1.

Sci Signal 2015 Nov 24;8(404):ra120. Epub 2015 Nov 24.

Chemical Genetics Laboratory, RIKEN, Wako, Saitama 351-0198, Japan. Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science, Wako, Saitama 351-0198, Japan. Graduate School of Science and Engineering, Saitama University, 645 Shimo-Okubo, Sakura-ku, Saitama 338-8570, Japan. Department of Medical Science Mathematics, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8510, Japan.

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http://dx.doi.org/10.1126/scisignal.aad0667DOI Listing
November 2015

A deletion mutation in myosin heavy chain 11 causing familial thoracic aortic dissection in two Japanese pedigrees.

Int J Cardiol 2015 Sep 3;195:290-2. Epub 2015 Jun 3.

Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.ijcard.2015.05.178DOI Listing
September 2015

Circulating Tumor DNA Analysis for Liver Cancers and Its Usefulness as a Liquid Biopsy.

Cell Mol Gastroenterol Hepatol 2015 Sep 17;1(5):516-534. Epub 2015 Jun 17.

Department of Gastroenterology and Metabolism, Applied Life Science, Institute of Biomedical and Health Science, Hiroshima University, Hiroshima, Japan; Liver Research Project Center, Hiroshima University, Hiroshima, Japan; Laboratory for Digestive Diseases, RIKEN Center for Integrative Medical Sciences, Hiroshima, Japan.

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http://dx.doi.org/10.1016/j.jcmgh.2015.06.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5301414PMC
September 2015

Gene expression profiling of DBA/2J mice cochleae treated with l-methionine and valproic acid.

Genom Data 2015 Sep 2;5:323-5. Epub 2015 Jul 2.

Laboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.

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http://dx.doi.org/10.1016/j.gdata.2015.06.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583681PMC
September 2015

Performance comparison of four commercial human whole-exome capture platforms.

Sci Rep 2015 Aug 3;5:12742. Epub 2015 Aug 3.

Laboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.

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http://dx.doi.org/10.1038/srep12742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522667PMC
August 2015

Primary microcephaly with anterior predominant pachygyria caused by novel compound heterozygous mutations in ASPM.

Pediatr Neurol 2015 May 7;52(5):e7-8. Epub 2015 Feb 7.

Department of Pediatrics, Yamagata University Faculty of Medicine, Yamagata, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.pediatrneurol.2015.01.019DOI Listing
May 2015

Sudden death in a case of megalencephaly capillary malformation associated with a de novo mutation in AKT3.

Childs Nerv Syst 2015 Mar 22;31(3):465-71. Epub 2014 Nov 22.

Department of Pediatric Neurosurgery, Takatsuki General Hospital, 1-3-13 Kosobecho, Takatsuki City, Osaka, 569-1192, Japan.

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http://dx.doi.org/10.1007/s00381-014-2589-yDOI Listing
March 2015

Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.

Hum Mol Genet 2015 Mar 26;24(6):1791-800. Epub 2014 Nov 26.

Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA.

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http://hmg.oxfordjournals.org/content/24/6/1791.full.pdf
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http://www.hmg.oxfordjournals.org/cgi/doi/10.1093/hmg/ddu583
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http://dx.doi.org/10.1093/hmg/ddu583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351379PMC
March 2015

KIF1A mutation in a patient with progressive neurodegeneration.

J Hum Genet 2014 Nov 25;59(11):639-41. Epub 2014 Sep 25.

Center for Medical Genetics, Keio University School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1038/jhg.2014.80DOI Listing
November 2014

HLA-DQB1*03 confers susceptibility to chronic hepatitis C in Japanese: a genome-wide association study.

PLoS One 2013 20;8(12):e84226. Epub 2013 Dec 20.

Laboratory for Digestive Diseases, Center for Integrative Medical Sciences, RIKEN, Hiroshima, Japan ; Department of Gastroenterology and Metabolism, Applied Life Sciences, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan ; Liver Research Project Center, Hiroshima University, Hiroshima, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0084226PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871580PMC
October 2014

Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.

Hum Mol Genet 2014 Oct 26;23(20):5492-504. Epub 2014 May 26.

Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan, Laboratory for Cardiovascular Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan, Division of Disease Diversity, Bioresource Research Center, Tokyo Medical and Dental University, Tokyo, Japan.

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http://hmg.oxfordjournals.org/content/early/2014/06/20/hmg.d
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http://www.hmg.oxfordjournals.org/cgi/doi/10.1093/hmg/ddu248
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http://dx.doi.org/10.1093/hmg/ddu248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168820PMC
October 2014

A meta-analysis identifies adolescent idiopathic scoliosis association with LBX1 locus in multiple ethnic groups.

J Med Genet 2014 Jun 10;51(6):401-6. Epub 2014 Apr 10.

Seay Center for Musculoskeletal Research, Texas Scottish Rite Hospital for Children, Dallas, USA Department of Orthopaedics, University of Texas Southwestern Medical Center at Dallas, Dallas, USA Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, USA McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center at Dallas, Dallas, USA.

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http://dx.doi.org/10.1136/jmedgenet-2013-102067DOI Listing
June 2014

The oncogenic polycomb histone methyltransferase EZH2 methylates lysine 120 on histone H2B and competes ubiquitination.

Neoplasia 2013 Nov;15(11):1251-61

Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo, Japan ; Department of Surgery, Kyorin University School of Medicine, Mitaka, Tokyo, Japan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858897PMC
http://dx.doi.org/10.1593/neo.131436DOI Listing
November 2013

Assessing the clinical utility of a genetic risk score constructed using 49 susceptibility alleles for type 2 diabetes in a Japanese population.

J Clin Endocrinol Metab 2013 Oct 16;98(10):E1667-73. Epub 2013 Aug 16.

Laboratory for Endocrinology, Metabolism, and Kidney Diseases, RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.

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http://dx.doi.org/10.1210/jc.2013-1642DOI Listing
October 2013