Publications by authors named "Tatiana G Kutateladze"

138 Publications

Characterization of functional disordered regions within chromatin-associated proteins.

iScience 2021 Feb 20;24(2):102070. Epub 2021 Jan 20.

Department of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.

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February 2021

Protocol for Biochemical Analysis and Structure Determination of the ZZ Domain of the E3 Ubiquitin Ligase HERC2.

STAR Protoc 2020 Dec 28;1(3):100155. Epub 2020 Oct 28.

Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA.

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December 2020

Suppression of canonical TGF-β signaling enables GATA4 to interact with H3K27me3 demethylase JMJD3 to promote cardiomyogenesis.

J Mol Cell Cardiol 2020 Dec 24;153:44-59. Epub 2020 Dec 24.

Division of Cardiology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Gates Center for Regenerative Medicine and Stem Cell Biology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; The Consortium for Fibrosis Research & Translation, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Pharmacology Graduate Program, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA. Electronic address:

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December 2020

ZZEF1 is a Histone Reader and Transcriptional Coregulator of Krüppel-Like Factors.

J Mol Biol 2021 Jan 21;433(2):166722. Epub 2020 Nov 21.

Center for Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA. Electronic address:

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January 2021

Molecular mechanism of the MORC4 ATPase activation.

Nat Commun 2020 10 29;11(1):5466. Epub 2020 Oct 29.

Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO, 80045, USA.

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October 2020

Inhibition of translation and immune responses by the virulence factor Nsp1 of SARS-CoV-2.

Signal Transduct Target Ther 2020 10 9;5(1):234. Epub 2020 Oct 9.

Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO, 80045, USA.

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October 2020

Enzymatic Reactions inside Biological Condensates.

J Mol Biol 2020 Aug 15:166624. Epub 2020 Aug 15.

Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA. Electronic address:

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August 2020

A triple action CDK4/6-PI3K-BET inhibitor with augmented cancer cell cytotoxicity.

Cell Discov 2020 28;6:49. Epub 2020 Jul 28.

Division of Pediatric Hematology and Oncology, Department of Pediatrics, Moores Cancer Center, University of California San Diego, La Jolla, CA USA.

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July 2020

Structural Insight into Binding of the ZZ Domain of HERC2 to Histone H3 and SUMO1.

Structure 2020 11 28;28(11):1225-1230.e3. Epub 2020 Jul 28.

Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA. Electronic address:

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November 2020

Design of thienopyranone-based BET inhibitors that bind multiple synthetic lethality targets.

Sci Rep 2020 07 21;10(1):12027. Epub 2020 Jul 21.

Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO, USA.

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July 2020

Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion.

Nat Commun 2020 07 3;11(1):3339. Epub 2020 Jul 3.

Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO, 80045, USA.

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July 2020

Molecular structure analyses suggest strategies to therapeutically target SARS-CoV-2.

Nat Commun 2020 06 10;11(1):2920. Epub 2020 Jun 10.

Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO, 80045, USA.

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June 2020

Exploring epigenetics with chemical tools.

Nat Chem 2020 06;12(6):506-508

Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO, USA.

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June 2020

KAP1 Is a Chromatin Reader that Couples Steps of RNA Polymerase II Transcription to Sustain Oncogenic Programs.

Mol Cell 2020 06 12;78(6):1133-1151.e14. Epub 2020 May 12.

Department of Microbiology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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June 2020

TCF19 Promotes Cell Proliferation through Binding to the Histone H3K4me3 Mark.

Biochemistry 2020 02 2;59(4):389-399. Epub 2019 Dec 2.

Biophysics and Structural Genomics Division , Saha Institute of Nuclear Physics , 1/AF Bidhannagar , Kolkata 700064 , India.

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February 2020

Molecular Basis for the PZP Domain of BRPF1 Association with Chromatin.

Structure 2020 01 8;28(1):105-110.e3. Epub 2019 Nov 8.

Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA. Electronic address:

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January 2020

Liquid-liquid phase separation is an intrinsic physicochemical property of chromatin.

Nat Struct Mol Biol 2019 12;26(12):1085-1086

Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO, USA.

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December 2019

E2F1 acetylation directs p300/CBP-mediated histone acetylation at DNA double-strand breaks to facilitate repair.

Nat Commun 2019 10 30;10(1):4951. Epub 2019 Oct 30.

Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Science Park, Smithville, TX, 78957, USA.

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October 2019

The PHD finger of Spp1 mediates histone modification cross-talk.

Biochem J 2019 08 28;476(16):2351-2354. Epub 2019 Aug 28.

Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, U.S.A.

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August 2019

MORC3 Forms Nuclear Condensates through Phase Separation.

iScience 2019 Jul 25;17:182-189. Epub 2019 Jun 25.

Department of Pharmacology, University of Colorado School of Medicine, 12801 East 17th Avenue, Aurora, CO 80045, USA. Electronic address:

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July 2019

Methylation of Histone H3K79 by Dot1L Requires Multiple Contacts with the Ubiquitinated Nucleosome.

Mol Cell 2019 06;74(5):862-863

Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA. Electronic address:

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June 2019

MORC3 Is a Target of the Influenza A Viral Protein NS1.

Structure 2019 06 18;27(6):1029-1033.e3. Epub 2019 Apr 18.

Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA. Electronic address:

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June 2019

Mechanism for autoinhibition and activation of the MORC3 ATPase.

Proc Natl Acad Sci U S A 2019 03 8;116(13):6111-6119. Epub 2019 Mar 8.

Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045;

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March 2019

Strategies for Generating Modified Nucleosomes: Applications within Structural Biology Studies.

ACS Chem Biol 2019 04 12;14(4):579-586. Epub 2019 Mar 12.

Department of Pharmacology , University of Colorado School of Medicine , Aurora , Colorado 80045 , United States.

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April 2019

The ZZ domain as a new epigenetic reader and a degradation signal sensor.

Crit Rev Biochem Mol Biol 2019 02 28;54(1):1-10. Epub 2019 Jan 28.

a Department of Pharmacology , University of Colorado School of Medicine , Aurora , CO , USA.

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February 2019

Mechanistic insight into the regulation of SQSTM1/p62.

Autophagy 2019 04 22;15(4):735-737. Epub 2019 Jan 22.

a Department of Pharmacology , University of Colorado School of Medicine , Aurora , CO , USA.

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April 2019