Tariq Enver

Tariq Enver

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Tariq Enver

Tariq Enver

Publications by authors named "Tariq Enver"

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91Publications

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Herpesviruses shape tumour microenvironment through exosomal transfer of viral microRNAs.

PLoS Pathog 2017 Aug 24;13(8):e1006524. Epub 2017 Aug 24.

UCL Cancer Institute, Research Department of Cancer Biology, Paul O'Gorman Building, University College London, London, England, United Kingdom.

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August 2017

Single-cell entropy for accurate estimation of differentiation potency from a cell's transcriptome.

Nat Commun 2017 Jun 1;8:15599. Epub 2017 Jun 1.

UCL Cancer Institute, Paul O'Gorman Building, University College London, 72 Huntley Street, London WC1E 6BT, UK.

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June 2017

Transcriptional regulation of Hhex in hematopoiesis and hematopoietic stem cell ontogeny.

Dev Biol 2017 04 9;424(2):236-245. Epub 2017 Feb 9.

MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK; Stem Cell Laboratory, UCL Cancer Institute, University College London, London WC1E 6DD, UK. Electronic address:

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April 2017

Single-Cell Analysis Identifies Distinct Stages of Human Endothelial-to-Hematopoietic Transition.

Cell Rep 2017 04;19(1):10-19

Section of Molecular Medicine and Gene Therapy, Lund Stem Cell Center, Lund University, BMC A12, 221 84 Lund, Sweden. Electronic address:

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April 2017

Characterization of Rare, Dormant, and Therapy-Resistant Cells in Acute Lymphoblastic Leukemia.

Cancer Cell 2016 Dec 1;30(6):849-862. Epub 2016 Dec 1.

Department of Gene Vectors, Helmholtz Zentrum München, German Center for Environmental Health (HMGU), 81377 Munich, Germany; German Consortium for Translational Cancer Research (DKTK), Partnering Site, Munich, 81377 Munich, Germany; Department of Pediatrics, Dr. von Hauner Children's Hospital, Ludwig Maximilians University München, 80337 Munich, Germany. Electronic address:

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December 2016

A network including TGFβ/Smad4, Gata2, and p57 regulates proliferation of mouse hematopoietic progenitor cells.

Exp Hematol 2016 May 10;44(5):399-409.e5. Epub 2016 Feb 10.

Division of Molecular Medicine and Gene Therapy, Lund Stem Cell Center, Lund University, Lund, Sweden.

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May 2016

Culture adaptation alters transcriptional hierarchies among single human embryonic stem cells reflecting altered patterns of differentiation.

PLoS One 2015 14;10(4):e0123467. Epub 2015 Apr 14.

Centre for Stem Cell Biology, Department of Biomedical Science, University of Sheffield, Sheffield, United Kingdom.

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April 2016

A somatic mutation of GFI1B identified in leukemia alters cell fate via a SPI1 (PU.1) centered genetic regulatory network.

Dev Biol 2016 Mar 3;411(2):277-286. Epub 2016 Feb 3.

UCL Cancer Institute, Paul O'Gorman Building 72 Huntley St., London WC1E6BT, United Kingdom. Electronic address:

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March 2016

Primed and ready: understanding lineage commitment through single cell analysis.

Trends Cell Biol 2015 Aug 22;25(8):459-67. Epub 2015 May 22.

University College London (UCL) Cancer Institute, Huntley Street, London WC1E 6BT, UK.

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August 2015

Macrophage-Induced Blood Vessels Guide Schwann Cell-Mediated Regeneration of Peripheral Nerves.

Cell 2015 Aug 13;162(5):1127-39. Epub 2015 Aug 13.

MRC Laboratory for Molecular Cell Biology, UCL, Gower Street, London WC1E 6BT, UK; UCL Cancer Institute, UCL, 72 Huntley Street, London WC1E 6DD, UK. Electronic address:

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August 2015

Single-Cell Network Analysis Identifies DDIT3 as a Nodal Lineage Regulator in Hematopoiesis.

Cell Rep 2015 Jun 4;11(10):1503-10. Epub 2015 Jun 4.

Stem Cell Laboratory, UCL Cancer Institute, University College London, London W1CE 6BT, UK. Electronic address:

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June 2015

Single-cell PCR profiling of gene expression in hematopoiesis.

Methods Mol Biol 2014 ;1185:21-42

Stem Cell Laboratory, University College London Cancer Institute, 72 Huntley Street, WC1E 6BT, London, UK.

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March 2015

The histone demethylase Jarid1b is required for hematopoietic stem cell self-renewal in mice.

Blood 2015 Mar 5;125(13):2075-8. Epub 2015 Feb 5.

Stem Cell Group, University College London Cancer Institute, University College London, London, United Kingdom.

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March 2015

Kaposi's sarcoma herpesvirus microRNAs induce metabolic transformation of infected cells.

PLoS Pathog 2014 Sep 25;10(9):e1004400. Epub 2014 Sep 25.

UCL Cancer Institute, Research Department of Cancer Biology, University College London, London, United Kingdom.

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September 2014

Leukemia propagating cells rebuild an evolving niche in response to therapy.

Cancer Cell 2014 Jun;25(6):778-93

Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Department of Pathophysiology and Ruijin Hospital, Shanghai Jiao Tong University School of Medicine (SJTU-SM), Shanghai 200025, China. Electronic address:

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June 2014

Transcriptional regulation of lineage commitment--a stochastic model of cell fate decisions.

PLoS Comput Biol 2013 22;9(8):e1003197. Epub 2013 Aug 22.

Computational Biology & Biological Physics, Department of Astronomy and Theoretical Physics, Lund University, Lund, Sweden.

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February 2014

Dynamic analysis of gene expression and genome-wide transcription factor binding during lineage specification of multipotent progenitors.

Cell Stem Cell 2013 Dec 10;13(6):754-68. Epub 2013 Oct 10.

Stem Cell Group, UCL Cancer Institute, University College London, London WC1E 6BT, UK; Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.

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December 2013

Cellular network entropy as the energy potential in Waddington's differentiation landscape.

Sci Rep 2013 Oct 24;3:3039. Epub 2013 Oct 24.

1] Statistical Cancer Genomics, Paul O'Gorman Building, UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6BT, United Kingdom [2] Centre for Mathematics and Physics in the Life Sciences and Experimental Biology, University College London, London WC1E6BT United Kingdom.

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October 2013

Hif-2α is not essential for cell-autonomous hematopoietic stem cell maintenance.

Blood 2013 Sep 26;122(10):1741-5. Epub 2013 Jul 26.

Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom.

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September 2013

Single-cell gene expression analysis reveals genetic associations masked in whole-tissue experiments.

Nat Biotechnol 2013 Aug 21;31(8):748-52. Epub 2013 Jul 21.

Department of Statistics, University of Oxford, Oxford, UK.

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August 2013

MiR-142-3p controls the specification of definitive hemangioblasts during ontogeny.

Dev Cell 2013 Aug 1;26(3):237-49. Epub 2013 Aug 1.

Stem Cell Laboratory, UCL Cancer Institute, WC1E 6BT London, UK.

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August 2013

Lineage specification: reading the instructions may help!

Curr Biol 2013 Aug;23(15):R662-5

UCL Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6BT, UK.

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August 2013

Identification of the chemokine CCL28 as a growth and survival factor for human hematopoietic stem and progenitor cells.

Blood 2013 May 18;121(19):3838-42, S1-15. Epub 2013 Mar 18.

Molecular Medicine and Gene Therapy, Lund Stem Cell Center, Lund University, Lund, Sweden.

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May 2013

A biophysical model for transcription factories.

BMC Biophys 2013 Feb 9;6. Epub 2013 Feb 9.

MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, OX3 9DS, UK.

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February 2013

Mitochondrial variability as a source of extrinsic cellular noise.

PLoS Comput Biol 2012 8;8(3):e1002416. Epub 2012 Mar 8.

Department of Physics, Clarendon Laboratory, Oxford, United Kingdom.

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June 2012

GATA-2 mediated regulation of normal hematopoietic stem/progenitor cell function, myelodysplasia and myeloid leukemia.

Int J Biochem Cell Biol 2012 Mar 14;44(3):457-60. Epub 2011 Dec 14.

National Institutes of Health Center for Biomedical Research Excellence in Stem Cell Biology, Roger Williams Medical Center, Boston University School of Medicine, Providence, RI 02908, United States.

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March 2012

Inferring rules of lineage commitment in haematopoiesis.

Nat Cell Biol 2012 Feb 19;14(3):287-94. Epub 2012 Feb 19.

Stem Cell Laboratory, UCL Cancer Institute, University College London, London WC1E 6BT, UK.

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February 2012

Human induced pluripotent stem cells are capable of B-cell lymphopoiesis.

Blood 2011 Apr 22;117(15):4008-11. Epub 2011 Feb 22.

Stem Cell Research Laboratory, National Health Service Blood and Transplant, John Radcliffe Hospital, Oxford, UK.

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April 2011

Connecting variability in global transcription rate to mitochondrial variability.

PLoS Biol 2010 Dec 14;8(12):e1000560. Epub 2010 Dec 14.

Medical Research Council Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom.

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December 2010

Tel1/ETV6 specifies blood stem cells through the agency of VEGF signaling.

Dev Cell 2010 Apr;18(4):569-78

MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK.

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April 2010

Forcing cells to change lineages.

Nature 2009 Dec;462(7273):587-94

Center for Genomic Regulation and ICREA, 08003 Barcelona, Spain.

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December 2009

Molecular targeting of cancer stem cells.

Cell Stem Cell 2009 Aug;5(2):125-6

MRC Molecular Haematology Unit, The Weatherall Institue of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.

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August 2009

Stem cell states, fates, and the rules of attraction.

Cell Stem Cell 2009 May;4(5):387-97

The Molecular Haematology Unit, The Weatherall Institute of Molecular Medicine, Oxford, UK.

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May 2009

The TEL-AML1 leukemia fusion gene dysregulates the TGF-beta pathway in early B lineage progenitor cells.

J Clin Invest 2009 Apr 16;119(4):826-36. Epub 2009 Mar 16.

Section of Haemato-Oncology, The Institute of Cancer Research, Sutton, Surrey, United Kingdom.

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April 2009

High GATA-2 expression inhibits human hematopoietic stem and progenitor cell function by effects on cell cycle.

Blood 2009 Mar 23;113(12):2661-72. Epub 2009 Jan 23.

Medical Research Council Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.

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March 2009

Computational modeling of the hematopoietic erythroid-myeloid switch reveals insights into cooperativity, priming, and irreversibility.

PLoS Comput Biol 2009 Jan 23;5(1):e1000268. Epub 2009 Jan 23.

Division of Biology, California Institute of Technology, Pasadena, California, United States of America.

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January 2009

GATA-2 regulates granulocyte-macrophage progenitor cell function.

Blood 2008 Dec 7;112(13):4862-73. Epub 2008 Oct 7.

Medical Research Council Hematology Unit, Weatherall Institute for Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.

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December 2008

Anterior definitive endoderm from ESCs reveals a role for FGF signaling.

Cell Stem Cell 2008 Oct;3(4):402-15

MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, King's Buildings, West Mains Road, Edinburgh EH9 3JQ, UK.

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October 2008

Stem cell researchers find their niche.

Development 2008 May;135(9):1569-73

Erasmus Medical Center, Department of Cell Biology, PO Box 2040, 3000 CA Rotterdam, The Netherlands.

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May 2008

MLLT3 regulates early human erythroid and megakaryocytic cell fate.

Cell Stem Cell 2008 Mar;2(3):264-73

MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.

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March 2008

Initiating and cancer-propagating cells in TEL-AML1-associated childhood leukemia.

Science 2008 Jan;319(5861):336-9

Medical Research Council (MRC) Molecular Haematology Unit, Weatherall Institute for Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK.

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January 2008

Coordinate gene regulation during hematopoiesis is related to genomic organization.

PLoS Biol 2007 Nov;5(11):e309

Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.

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November 2007

CD56bright human NK cells differentiate into CD56dim cells: role of contact with peripheral fibroblasts.

J Immunol 2007 Jul;179(1):89-94

Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, UK.

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July 2007

Inference, validation, and dynamic modeling of transcription networks in multipotent hematopoietic cells.

Ann N Y Acad Sci 2007 Jun 18;1106:30-40. Epub 2007 Apr 18.

Weatherall Institute of Molecular Medicine, Molecular Haematology Unit, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK.

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June 2007

Bifurcation dynamics in lineage-commitment in bipotent progenitor cells.

Dev Biol 2007 May 3;305(2):695-713. Epub 2007 Mar 3.

Department of Surgery and Vascular Biology Program, Children's Hospital, Harvard Medical School, and Harvard Stem Cell Institute, Children's Hospital, 1 Blackfan Circle, Boston, MA 02115, USA.

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May 2007

Isoform-specific potentiation of stem and progenitor cell engraftment by AML1/RUNX1.

PLoS Med 2007 May;4(5):e172

Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan.

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May 2007

NOV (CCN3) functions as a regulator of human hematopoietic stem or progenitor cells.

Science 2007 Apr;316(5824):590-3

Medical Research Council Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, OX3 9DS, UK.

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April 2007

ETO-2 associates with SCL in erythroid cells and megakaryocytes and provides repressor functions in erythropoiesis.

Mol Cell Biol 2005 Dec;25(23):10235-50

MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom.

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December 2005

Cellular differentiation hierarchies in normal and culture-adapted human embryonic stem cells.

Hum Mol Genet 2005 Nov 13;14(21):3129-40. Epub 2005 Sep 13.

MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, UK.

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November 2005

Haploinsufficiency of GATA-2 perturbs adult hematopoietic stem-cell homeostasis.

Blood 2005 Jul 5;106(2):477-84. Epub 2005 Apr 5.

Center for Regenerative Medicine and Technology, Massachusetts General Hospital, Boston, MA 02129, USA.

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July 2005

Wt1 is not essential for hematopoiesis in the mouse.

Leuk Res 2005 Jul 17;29(7):803-12. Epub 2005 Feb 17.

Section of Paediatric Oncology, Institute of Cancer Research, 15 Cotswold Road, Belmont, Sutton, Surrey SM2 5NG, UK.

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July 2005

Developmental impact of leukemic fusion genes on stem cell fate.

Ann N Y Acad Sci 2005 Jun;1044:16-23

Molecular Haematology Unit, The Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK.

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June 2005

GATA transcription factors inhibit cytokine-dependent growth and survival of a hematopoietic cell line through the inhibition of STAT3 activity.

J Biol Chem 2005 Apr 25;280(13):13163-70. Epub 2005 Jan 25.

Department of Hematology/Oncology, Osaka University Graduate School of Medicine, 2-2, Yamada-oka, Suita, Osaka 565-0871, Japan.

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April 2005

Notch signals inhibit the development of erythroid/megakaryocytic cells by suppressing GATA-1 activity through the induction of HES1.

J Biol Chem 2005 Feb 24;280(6):4929-39. Epub 2004 Nov 24.

Department of Hematology and Oncology, Osaka University Graduate School of Medicine, 2-2, Yamada-oka, Suita, Osaka 565-0871, Japan.

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February 2005

Receptor and secreted targets of Wnt-1/beta-catenin signalling in mouse mammary epithelial cells.

BMC Cancer 2005 Jan 10;5. Epub 2005 Jan 10.

Section of Gene Function and Regulation, Institute of Cancer Research, London, SW3 6JB, UK.

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January 2005

Directing oncogenic fusion genes into stem cells via an SCL enhancer.

Proc Natl Acad Sci U S A 2005 Jan 13;102(4):1133-8. Epub 2005 Jan 13.

Section of Haemato-Oncology, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, United Kingdom.

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January 2005

Cross talk between retinoic acid signaling and transcription factor GATA-2.

Mol Cell Biol 2004 Aug;24(15):6824-36

Section of Gene Function and Regulation, Institute of Cancer Research, London SW3 6JB, UK.

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August 2004

Modeling first-hit functions of the t(12;21) TEL-AML1 translocation in mice.

Proc Natl Acad Sci U S A 2004 Jun 20;101(22):8443-8. Epub 2004 May 20.

Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan.

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June 2004

Role of the TEL-AML1 fusion gene in the molecular pathogenesis of childhood acute lymphoblastic leukaemia.

Oncogene 2004 May;23(24):4275-83

Section of Haematological Oncology, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK.

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May 2004

Functional and molecular characterisation of mammary side population cells.

Breast Cancer Res 2003 14;5(1):R1-8. Epub 2002 Oct 14.

Breakthrough Toby Robins Breast Cancer Centre, Institute of Cancer Research, London, UK.

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May 2003

Molecular complexities of stem cells.

Curr Opin Hematol 2003 May;10(3):220-8

The Institute of Cancer Research, Chester Beatty Laboratories, London, UK.

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May 2003

Plasticity revisited.

Curr Opin Cell Biol 2002 Dec;14(6):749-55

Section of Gene Function and Regulation, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, SW3 6JB, London, UK.

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December 2002

GATA-2/estrogen receptor chimera regulates cytokine-dependent growth of hematopoietic cells through accumulation of p21(WAF1) and p27(Kip1) proteins.

Blood 2002 Nov 12;100(10):3512-20. Epub 2002 Jul 12.

Department of Hematology/Oncology and Molecular Oncology, Osaka University Graduate School of Medicine, 2-2, Yamada-oka, Suita, Osaka, Japan.

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November 2002

Retroviral vectors for establishing tetracycline-regulated gene expression in an otherwise recalcitrant cell line.

BMC Mol Biol 2002 Sep 3;3:13. Epub 2002 Sep 3.

Section of Gene Function and Regulation, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, United Kingdom.

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September 2002

Transcription factor-mediated lineage switching reveals plasticity in primary committed progenitor cells.

EMBO J 2002 Jul;21(14):3770-81

Section of Gene Function and Regulation, Institute of Cancer Research, Chester Beatty Laboratories, London SW3 6JB, UK.

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July 2002

GATA-2 and GATA-2/ER display opposing activities in the development and differentiation of blood progenitors.

EMBO J 2002 Jun;21(12):3060-9

Department of Molecular Cell Biology, Research Institute for Microbial Diseases, Osaka University, Suita 565-0871, Japan.

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June 2002

Interactions of GATA-2 with the promyelocytic leukemia zinc finger (PLZF) protein, its homologue FAZF, and the t(11;17)-generated PLZF-retinoic acid receptor alpha oncoprotein.

Blood 2002 May;99(9):3404-10

Section of Gene Function and Regulation, Institute of Cancer Research, Chester Beatty Laboratories, London, United Kingdom.

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May 2002