Publications by authors named "Tara L Spires-Jones"

90Publications

Editorial.

Brain Commun 2020 13;2(1):fcz051. Epub 2020 Jan 13.

Edinburgh, UK.

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http://dx.doi.org/10.1093/braincomms/fcz051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425370PMC
January 2020

The physiological roles of tau and Aβ: implications for Alzheimer's disease pathology and therapeutics.

Acta Neuropathol 2020 Oct 29;140(4):417-447. Epub 2020 Jul 29.

Centre for Discovery Brain Sciences and the UK Dementia Research Institute, The University of Edinburgh, 1 George Square, Edinburgh, EH8 9JZ, Scotland, UK.

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http://dx.doi.org/10.1007/s00401-020-02196-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498448PMC
October 2020

Generation of twenty four induced pluripotent stem cell lines from twenty four members of the Lothian Birth Cohort 1936.

Stem Cell Res 2020 07 20;46:101851. Epub 2020 May 20.

iPSC Core, The David Janet Polak Foundation Stem Cell Core Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Cedars-Sinai Biomanufacturing Center, West Hollywood, CA 90069, USA; Board of Governors-Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2020.101851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347008PMC
July 2020

PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins.

Acta Neuropathol 2020 03 18;139(3):503-526. Epub 2019 Dec 18.

Laboratory for Neurodegenerative Research, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Hale Building for Transformative Medicine, 60 Fenwood Road, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1007/s00401-019-02114-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035229PMC
March 2020

Clusterin accumulates in synapses in Alzheimer's disease and is increased in apolipoprotein E4 carriers.

Brain Commun 2019 24;1(1):fcz003. Epub 2019 Jun 24.

Centre for Discovery Brain Sciences, UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1093/braincomms/fcz003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904249PMC
June 2019

Childhood intelligence attenuates the association between biological ageing and health outcomes in later life.

Transl Psychiatry 2019 11 28;9(1):323. Epub 2019 Nov 28.

Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1038/s41398-019-0657-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883059PMC
November 2019

Editorial.

Brain Commun 2019 30;1(1):fcz001. Epub 2019 May 30.

Edinburgh, UK.

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http://dx.doi.org/10.1093/braincomms/fcz001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425211PMC
May 2019

Nanoscale structure of amyloid-β plaques in Alzheimer's disease.

Sci Rep 2019 03 26;9(1):5181. Epub 2019 Mar 26.

Memory Unit, Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau - Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1038/s41598-019-41443-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435662PMC
March 2019

Sleep well to slow Alzheimer's progression?

Science 2019 02;363(6429):813-814

UK Dementia Research Institute, Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1126/science.aaw5583DOI Listing
February 2019

Beyond the neuron-cellular interactions early in Alzheimer disease pathogenesis.

Nat Rev Neurosci 2019 02;20(2):94-108

The University of Edinburgh Centre for Discovery Brain Sciences, UK Dementia Research Institute, Edinburgh, UK.

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http://dx.doi.org/10.1038/s41583-018-0113-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545070PMC
February 2019

Complementing Tau: New Data Show that the Complement System Is Involved in Degeneration in Tauopathies.

Neuron 2018 12;100(6):1267-1269

UK Dementia Research Institute and Centre for Discovery Brain Sciences, University of Edinburgh, 1 George Square, Edinburgh EH8 9JZ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2018.12.003DOI Listing
December 2018

Region-specific depletion of synaptic mitochondria in the brains of patients with Alzheimer's disease.

Acta Neuropathol 2018 11 6;136(5):747-757. Epub 2018 Sep 6.

Centre for Discovery Brain Sciences, UK Dementia Research Institute, The University of Edinburgh, 1 George Square, Edinburgh, EH8 9JZ, UK.

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http://dx.doi.org/10.1007/s00401-018-1903-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208730PMC
November 2018

A brain boost to fight Alzheimer's disease.

Science 2018 09;361(6406):975-976

Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1126/science.aau8060DOI Listing
September 2018

Modeling Alzheimer's disease brains in vitro.

Nat Neurosci 2018 07;21(7):899-900

UK Dementia Research Institute and Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1038/s41593-018-0177-2DOI Listing
July 2018

Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau.

Neuron 2018 02 1;97(4):823-835.e8. Epub 2018 Feb 1.

VIB-KU Leuven Center for Brain & Disease Research, 3000 Leuven, Belgium; Department of Neurosciences and Leuven Brain Institute, KU Leuven, 3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2018.01.022DOI Listing
February 2018

Conditional Deletion of PDK1 in the Forebrain Causes Neuron Loss and Increased Apoptosis during Cortical Development.

Front Cell Neurosci 2017 20;11:330. Epub 2017 Oct 20.

State Key Laboratory of Pharmaceutical Biotechnology, Model Animal Research Center, Ministry of Education (MOE) Key Laboratory of Model Animal for Disease Study, Nanjing University, Nanjing, China.

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http://dx.doi.org/10.3389/fncel.2017.00330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655024PMC
October 2017

Human Brain-Derived Aβ Oligomers Bind to Synapses and Disrupt Synaptic Activity in a Manner That Requires APP.

J Neurosci 2017 12 3;37(49):11947-11966. Epub 2017 Nov 3.

Laboratory for Neurodegenerative Research, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115,

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http://dx.doi.org/10.1523/JNEUROSCI.2009-17.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719975PMC
December 2017

Interactions of pathological proteins in neurodegenerative diseases.

Acta Neuropathol 2017 08 11;134(2):187-205. Epub 2017 Apr 11.

Departement Neurowetenschappen, Katholieke Universiteit Leuven, Herestraat 49, 3000, Leuven, Belgium.

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http://dx.doi.org/10.1007/s00401-017-1709-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508034PMC
August 2017

Spread of tau down neural circuits precedes synapse and neuronal loss in the rTgTauEC mouse model of early Alzheimer's disease.

Synapse 2017 06 6;71(6). Epub 2017 Mar 6.

The University of Edinburgh Centre for Cognitive and Neural Systems, Centre for Dementia Prevention and the Euan MacDonald Centre for Motor Neurone Disease Research, 1 George Square, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1002/syn.21965DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516127PMC
June 2017

Non-Fibrillar Oligomeric Amyloid-β within Synapses.

J Alzheimers Dis 2016 05;53(3):787-800

The University of Edinburgh Centre for Cognitive and Neural Systems, Centre for Dementia Prevention and the Euan MacDonald Centre for Motor Neurone Disease Research, Edinburgh, UK.

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http://dx.doi.org/10.3233/JAD-160007DOI Listing
May 2016

Amyloid-beta oligomerization is associated with the generation of a typical peptide fragment fingerprint.

Alzheimers Dement 2016 09 26;12(9):996-1013. Epub 2016 Apr 26.

School of Life Sciences, Proteomics Core Facility, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2016.03.011DOI Listing
September 2016

Synaptic pathology: A shared mechanism in neurological disease.

Ageing Res Rev 2016 07 20;28:72-84. Epub 2016 Apr 20.

Centre for Cognitive and Neural Systems, 1 George Square, University of Edinburgh, EH8 9JZ, UK; Euan MacDonald Centre for Motor Neurone Disease Research, Chancellor's Building, 49 Little France Crescent, University of Edinburgh, EH16 4SB, UK; Centre for Dementia Prevention, University of Edinburgh Kennedy Tower, Royal Edinburgh Hospital, EH10 5HF, UK. Electronic address:

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http://dx.doi.org/10.1016/j.arr.2016.04.005DOI Listing
July 2016

You are not alone: selecting your group members and leading an outstanding research team.

Eur J Neurosci 2015 Dec 27;42(12):3012-7. Epub 2015 Nov 27.

FENS-Kavli Network of Excellence, Europe-wide.

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http://dx.doi.org/10.1111/ejn.13109DOI Listing
December 2015

Pathological tau disrupts ongoing network activity.

Neuron 2015 Mar 19;85(5):959-66. Epub 2015 Feb 19.

Gonda Brain Research Center, Bar-Ilan University, 52900 Ramat Gan, Israel; MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, 114 16th Street, Charlestown, MA 02129, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2015.01.025DOI Listing
March 2015

Carboxy terminus heat shock protein 70 interacting protein reduces tau-associated degenerative changes.

J Alzheimers Dis 2015 ;44(3):937-47

Massachusetts General Hospital, Harvard Medical School, Charlestown, USA Centre for Cognitive and Neural Systems and the Euan MacDonald Centre, University of Edinburgh, UK.

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http://datashare.is.ed.ac.uk/bitstream/handle/10283/849/CHIP
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http://www.medra.org/servlet/aliasResolver?alias=iospress&am
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http://dx.doi.org/10.3233/JAD-142094DOI Listing
October 2015

Frequent and symmetric deposition of misfolded tau oligomers within presynaptic and postsynaptic terminals in Alzheimer's disease.

Acta Neuropathol Commun 2014 Oct 21;2:146. Epub 2014 Oct 21.

MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Building 114, 16th Street, Charlestown, MA, 02129, USA.

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http://dx.doi.org/10.1186/s40478-014-0146-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209049PMC
October 2014

Tau pathology does not affect experience-driven single-neuron and network-wide Arc/Arg3.1 responses.

Acta Neuropathol Commun 2014 Jun 10;2:63. Epub 2014 Jun 10.

Alzheimer's Disease Research Laboratory, Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129, MA, USA.

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http://dx.doi.org/10.1186/2051-5960-2-63DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229905PMC
June 2014

The intersection of amyloid beta and tau at synapses in Alzheimer's disease.

Neuron 2014 May;82(4):756-71

Massachusetts General Hospital, Harvard Medical School, Neurology, 114 16(th) Street, Charlestown, MA 02129, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2014.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135182PMC
May 2014

Neurofibrillary tangle-bearing neurons are functionally integrated in cortical circuits in vivo.

Proc Natl Acad Sci U S A 2014 Jan 24;111(1):510-4. Epub 2013 Dec 24.

Alzheimer's Disease Research Laboratory, Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129.

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http://dx.doi.org/10.1073/pnas.1318807111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890777PMC
January 2014

Tau causes synapse loss without disrupting calcium homeostasis in the rTg4510 model of tauopathy.

PLoS One 2013 20;8(11):e80834. Epub 2013 Nov 20.

Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts, United States of America ; MassGeneral Institute for Neurodegenerative Disease at Massachusetts General Hospital, Charlestown, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0080834PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835324PMC
December 2014

Soluble pathological tau in the entorhinal cortex leads to presynaptic deficits in an early Alzheimer's disease model.

Acta Neuropathol 2014 Feb 24;127(2):257-70. Epub 2013 Nov 24.

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 114 16th Street Room 2009, Charlestown, MA, 02129, USA.

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http://dx.doi.org/10.1007/s00401-013-1215-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946978PMC
February 2014

Propagation of tau pathology in Alzheimer's disease: identification of novel therapeutic targets.

Alzheimers Res Ther 2013 23;5(5):49. Epub 2013 Oct 23.

Massachusetts General Hospital, Harvard Medical School, 114 16th Street, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1186/alzrt214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978816PMC
June 2014

Endogenous tau aggregates in oligodendrocytes of rTg4510 mice induced by human P301L tau.

J Alzheimers Dis 2014 ;38(3):589-600

Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, University of Florida, Gainesville, FL, USA.

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http://dx.doi.org/10.3233/JAD-130986DOI Listing
July 2014

Reversal of neurofibrillary tangles and tau-associated phenotype in the rTgTauEC model of early Alzheimer's disease.

J Neurosci 2013 Aug;33(33):13300-11

MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Alzheimer's Disease Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.0881-13.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742920PMC
August 2013

Tau-amyloid interactions in the rTgTauEC model of early Alzheimer's disease suggest amyloid-induced disruption of axonal projections and exacerbated axonal pathology.

J Comp Neurol 2013 Dec;521(18):4236-48

King's College London, Institute of Psychiatry, Department of Neuroscience, London, SE5 8AF, UK; Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, 02129, USA.

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http://dx.doi.org/10.1002/cne.23411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797265PMC
December 2013

Brain interstitial oligomeric amyloid β increases with age and is resistant to clearance from brain in a mouse model of Alzheimer's disease.

FASEB J 2013 Aug 2;27(8):3239-48. Epub 2013 May 2.

Alzheimer's Disease Research Laboratory, Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, 16th St., Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1096/fj.13-229666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3714573PMC
August 2013

Synaptic alterations in the rTg4510 mouse model of tauopathy.

J Comp Neurol 2013 Apr;521(6):1334-53

Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts 02118, USA.

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http://doi.wiley.com/10.1002/cne.23234
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http://dx.doi.org/10.1002/cne.23234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725804PMC
April 2013

Soluble forms of tau are toxic in Alzheimer's disease.

Transl Neurosci 2012 Sep;3(3):223-233

MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown Massachusetts 02129 ; Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston Massachusetts 02118.

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http://dx.doi.org/10.2478/s13380-012-0032-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460520PMC
September 2012

Orchestrated experience-driven Arc responses are disrupted in a mouse model of Alzheimer's disease.

Nat Neurosci 2012 Oct 26;15(10):1422-9. Epub 2012 Aug 26.

Alzheimer's Disease Research Laboratory, Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.

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http://dx.doi.org/10.1038/nn.3199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458168PMC
October 2012

Inhibition of the NFAT pathway alleviates amyloid β neurotoxicity in a mouse model of Alzheimer's disease.

J Neurosci 2012 Feb;32(9):3176-92

Massachusetts General Hospital, Department of Neurology/Alzheimer's Disease Research Laboratory, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.6439-11.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296329PMC
February 2012

Propagation of tau pathology in a model of early Alzheimer's disease.

Neuron 2012 Feb;73(4):685-97

MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Alzheimer's Disease Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1016/j.neuron.2011.11.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292759PMC
February 2012

Nanoparticles enhance brain delivery of blood-brain barrier-impermeable probes for in vivo optical and magnetic resonance imaging.

Proc Natl Acad Sci U S A 2011 Nov 7;108(46):18837-42. Epub 2011 Nov 7.

Department of Neurology, Massachusetts General Hospital and Harvard Medical School , Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1073/pnas.1111405108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219113PMC
November 2011

Alzheimer's disease: synapses gone cold.

Mol Neurodegener 2011 Aug 26;6(1):63. Epub 2011 Aug 26.

Massachusetts General Hospital, Harvard Medical School, 114 16th Street, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1186/1750-1326-6-63DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178498PMC
August 2011

Tau accumulation causes mitochondrial distribution deficits in neurons in a mouse model of tauopathy and in human Alzheimer's disease brain.

Am J Pathol 2011 Oct 18;179(4):2071-82. Epub 2011 Aug 18.

MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown Massachusetts, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1016/j.ajpath.2011.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181340PMC
October 2011

Soluble tau species, not neurofibrillary aggregates, disrupt neural system integration in a tau transgenic model.

J Neuropathol Exp Neurol 2011 Jul;70(7):588-95

Massachusetts General Hospital/Harvard Medical School, MassGeneral Institute for Neurodegenerative Disease, Charlestown, 02129, USA.

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http://dx.doi.org/10.1097/NEN.0b013e318220a658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118928PMC
July 2011

Are tangles as toxic as they look?

J Mol Neurosci 2011 Nov 3;45(3):438-44. Epub 2011 Jun 3.

Massachusetts General Hospital, Harvard Medical School, 114 16th Street, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1007/s12031-011-9566-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173560PMC
November 2011

T cell mediated cerebral hemorrhages and microhemorrhages during passive Aβ immunization in APPPS1 transgenic mice.

Mol Neurodegener 2011 Mar 9;6:22. Epub 2011 Mar 9.

MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Department of Neurology, Alzheimer's Disease Research Laboratory, 02129 Charlestown, MA USA.

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http://molecularneurodegeneration.biomedcentral.com/articles
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http://dx.doi.org/10.1186/1750-1326-6-22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068114PMC
March 2011

Apolipoprotein E: isoform specific differences in tertiary structure and interaction with amyloid-β in human Alzheimer brain.

PLoS One 2011 Jan 31;6(1):e14586. Epub 2011 Jan 31.

Harvard Medical School, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0014586PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031506PMC
January 2011

Monitoring protein aggregation and toxicity in Alzheimer's disease mouse models using in vivo imaging.

Methods 2011 Mar 14;53(3):201-7. Epub 2010 Dec 14.

Massachusetts General Hospital/Harvard Medical School, 114 16th Street, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1016/j.ymeth.2010.12.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049845PMC
March 2011

Calcineurin inhibition with FK506 ameliorates dendritic spine density deficits in plaque-bearing Alzheimer model mice.

Neurobiol Dis 2011 Mar 4;41(3):650-4. Epub 2010 Dec 4.

MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital/Harvard Medical School, Charlestown, MA 02129, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S09699961100038
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http://dx.doi.org/10.1016/j.nbd.2010.11.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031746PMC
March 2011

Calcineurin inhibition with systemic FK506 treatment increases dendritic branching and dendritic spine density in healthy adult mouse brain.

Neurosci Lett 2011 Jan 21;487(3):260-3. Epub 2010 Oct 21.

Massachusetts General Hospital/Harvard Medical School, MassGeneral Institute for Neurodegenerative Diseases, 114 16th Street, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1016/j.neulet.2010.10.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3010509PMC
January 2011

Caspase activation precedes and leads to tangles.

Nature 2010 Apr 31;464(7292):1201-4. Epub 2010 Mar 31.

MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Alzheimer's Disease Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1038/nature08890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3091360PMC
April 2010

A reporter of local dendritic translocation shows plaque- related loss of neural system function in APP-transgenic mice.

J Neurosci 2009 Oct;29(40):12636-40

MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, MA, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.1948-09.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789808PMC
October 2009

Differential effect of three-repeat and four-repeat tau on mitochondrial axonal transport.

J Neurochem 2009 Oct 3;111(2):417-27. Epub 2009 Aug 3.

MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2009.06316.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831412PMC
October 2009

Tangle-bearing neurons survive despite disruption of membrane integrity in a mouse model of tauopathy.

J Neuropathol Exp Neurol 2009 Jul;68(7):757-61

MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1097/NEN.0b013e3181a9fc66DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756569PMC
July 2009

A single dose of passive immunotherapy has extended benefits on synapses and neurites in an Alzheimer's disease mouse model.

Brain Res 2009 Jul 22;1280:178-85. Epub 2009 May 22.

MassGeneral Institute for Neurodegenerative Disease, Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1016/j.brainres.2009.05.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709805PMC
July 2009

Tau pathophysiology in neurodegeneration: a tangled issue.

Trends Neurosci 2009 Mar 21;32(3):150-9. Epub 2009 Jan 21.

MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1016/j.tins.2008.11.007DOI Listing
March 2009

Passive immunotherapy rapidly increases structural plasticity in a mouse model of Alzheimer disease.

Neurobiol Dis 2009 Feb 6;33(2):213-20. Epub 2008 Nov 6.

MassGeneral Institute for Neurodegenerative Disease, Harvard Medical School, Charlestown, MA, USA.

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http://dx.doi.org/10.1016/j.nbd.2008.10.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672591PMC
February 2009

Two postprocessing techniques for the elimination of background autofluorescence for fluorescence lifetime imaging microscopy.

J Biomed Opt 2008 Jan-Feb;13(1):014008

Harvard Medical School, Massachusetts General Hospital, MassGeneral Institute for Neurodegenerative Disorders, 114 16th Street, Charlestown, Massachusetts 02129, USA.

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http://biomedicaloptics.spiedigitallibrary.org/article.aspx?
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http://dx.doi.org/10.1117/1.2837169DOI Listing
June 2008

Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease.

Nature 2008 Feb;451(7179):720-4

Alzheimer's Disease Research Laboratory, Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1038/nature06616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3264491PMC
February 2008

Impaired spine stability underlies plaque-related spine loss in an Alzheimer's disease mouse model.

Am J Pathol 2007 Oct 23;171(4):1304-11. Epub 2007 Aug 23.

MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital/ Harvard Medical School, Charlestown, Massachusetts, USA.

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http://dx.doi.org/10.2353/ajpath.2007.070055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1988879PMC
October 2007