Tapio Visakorpi

Tapio Visakorpi

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Tapio Visakorpi

Publications by authors named "Tapio Visakorpi"

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Comparative analysis of tissue reconstruction algorithms for 3D histology.

Bioinformatics 2018 09;34(17):3013-3021

Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.

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http://dx.doi.org/10.1093/bioinformatics/bty210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129300PMC
September 2018

Proteomics of prostate cancer - revealing how cancer cells master their messy genomes.

Oncoscience 2018 Jul 31;5(7-8):216-217. Epub 2018 Jul 31.

Leena Latonen: Prostate Cancer Research Center, Faculty of Medicine and Life Sciences and BioMediTech Institute, University of Tampere, Tampere, Finland; FimLab laboratories, Tampere University Hospital, Tampere, Finland.

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http://impactjournals.com/oncoscience/index.php?pii=453
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http://dx.doi.org/10.18632/oncoscience.453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142899PMC
July 2018

Expression of neuroendocrine differentiation markers in lethal metastatic castration-resistant prostate cancer.

Pathol Res Pract 2018 Jun 26;214(6):848-856. Epub 2018 Apr 26.

Prostate Cancer Research Center, Faculty of Medicine and Life Sciences and BioMediTech Institute, University of Tampere, Tampere, FI-33014, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.prp.2018.04.015DOI Listing
June 2018

Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets.

Nat Genet 2018 05 16;50(5):682-692. Epub 2018 Apr 16.

The Institute of Cancer Research, London, UK.

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http://www.nature.com/articles/s41588-018-0086-z
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http://dx.doi.org/10.1038/s41588-018-0086-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372064PMC
May 2018

Endocrinology of prostate cancer.

Mol Cell Endocrinol 2018 02;462(Pt A):1-2

Prostate Cancer Research Center, Institute for Biomedical Technology, FI-33014 University of Tampere, Biokatu, 6-8 33520, Tampere, Finland.

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http://dx.doi.org/10.1016/j.mce.2018.01.005DOI Listing
February 2018

The expression of AURKA is androgen regulated in castration-resistant prostate cancer.

Sci Rep 2017 12 21;7(1):17978. Epub 2017 Dec 21.

BioMediTech Institute, Faculty of Medicine and Life Sciences, University of Tampere, Fimlab Laboratories, Tampere University Hospital, Tampere, Finland.

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http://dx.doi.org/10.1038/s41598-017-18210-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740165PMC
December 2017

Measuring the Expression of microRNAs Regulated by Androgens.

Methods Mol Biol 2016 ;1443:151-63

Prostate Cancer Research Center, Institute of Biosciences and Medical Technology-BioMediTech and Fimlab Laboratories, University of Tampere and Tampere University Hospital, Tampere, Finland.

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http://dx.doi.org/10.1007/978-1-4939-3724-0_10DOI Listing
November 2017

In Vivo Expression of miR-32 Induces Proliferation in Prostate Epithelium.

Am J Pathol 2017 Nov 19;187(11):2546-2557. Epub 2017 Aug 19.

Prostate Cancer Research Center, Faculty of Medicine and Life Sciences and BioMediTech, University of Tampere, Tampere, Finland; Fimlab Laboratories, Tampere University Hospital, Tampere, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2017.07.012DOI Listing
November 2017

A Four-kallikrein Panel and β-Microseminoprotein in Predicting High-grade Prostate Cancer on Biopsy: An Independent Replication from the Finnish Section of the European Randomized Study of Screening for Prostate Cancer.

Eur Urol Focus 2017 Nov 11. Epub 2017 Nov 11.

Prostate Cancer Research Center, Institute of Biosciences and Medical Technology, University of Tampere, Tampere, Finland; Departments of Laboratory Medicine, Surgery, and Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK; Department of Translational Medicine, Lund University, Malmö, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.euf.2017.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5948115PMC
November 2017

Incidence of Mucinous Metaplasia in the Prostate of FVB/N Mice (Mus musculus).

Comp Med 2016 ;66(4):286-9

Institute of Biosciences and Medical Technology (BioMediTech), University of Tampere, Fimlab Laboratories, Tampere University Hospital, Tampere, Finland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983170PMC
October 2017

Strong FGFR3 staining is a marker for FGFR3 fusions in diffuse gliomas.

Neuro Oncol 2017 Sep;19(9):1206-1216

BioMediTech Institute and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland; Department of Signal Processing, Tampere University of Technology, Tampere, Finland; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas; Science Center, Tampere University Hospital, Tampere, Finland; Fimlab Laboratories Ltd., Tampere University Hospital, Tampere, Finland; Unit of Neurosurgery, Tampere University Hospital, Tampere, Finland; Pori unit, Tampere University of Technology, Pori, Finland; Department of Pathology, University of Tampere, Tampere, Finland; Department of Cancer Biology, Comprehensive Cancer Center of Wake Forest Baptist Medical Center, Winston-Salem, North Carolina.

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http://dx.doi.org/10.1093/neuonc/nox028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570261PMC
September 2017

Androgen Receptor Deregulation Drives Bromodomain-Mediated Chromatin Alterations in Prostate Cancer.

Cell Rep 2017 06;19(10):2045-2059

Centre for Molecular Medicine Norway, Nordic European Molecular Biology Laboratory Partnership, Forskningsparken, University of Oslo, 21 0349 Oslo, Norway; Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital, 0424 Oslo, Norway; PCUK Movember Centre of Excellence, CCRCB, Queen's University, Belfast BT7 1NN, Northern Ireland, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.05.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675034PMC
June 2017

Analysis of spatial heterogeneity in normal epithelium and preneoplastic alterations in mouse prostate tumor models.

Sci Rep 2017 03 20;7:44831. Epub 2017 Mar 20.

Prostate Cancer Research Center, Faculty of Medicine and Life Sciences and BioMediTech, University of Tampere, Tampere, Finland.

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http://dx.doi.org/10.1038/srep44831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357939PMC
March 2017

The Molecular Evolution of Castration-resistant Prostate Cancer.

Eur Urol Focus 2016 Dec 9;2(5):506-513. Epub 2016 Dec 9.

Prostate Cancer Research Center, Institute of Biosciences and Medical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland.

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http://dx.doi.org/10.1016/j.euf.2016.11.012DOI Listing
December 2016

The Potential of MicroRNAs as Prostate Cancer Biomarkers.

Eur Urol 2016 08 22;70(2):312-22. Epub 2016 Jan 22.

Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Center for RNA Interference and Non-Coding RNAs, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2015.12.054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927364PMC
August 2016

Amplification of the 9p13.3 chromosomal region in prostate cancer.

Genes Chromosomes Cancer 2016 08 2;55(8):617-25. Epub 2016 May 2.

Institute of Biosciences and Medical Technology - BioMediTech, University of Tampere, Finland.

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http://dx.doi.org/10.1002/gcc.22364DOI Listing
August 2016

Expressional profiling of prostate cancer risk SNPs at 11q13.5 identifies DGAT2 as a new target gene.

Genes Chromosomes Cancer 2016 08 24;55(8):661-73. Epub 2016 May 24.

BioMediTech and Prostate Cancer Research Center, University of Tampere, Tampere, Finland.

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http://dx.doi.org/10.1002/gcc.22368DOI Listing
August 2016

Copy number increase of oncoprotein CIP2A is associated with poor patient survival in human head and neck squamous cell carcinoma.

J Oral Pathol Med 2016 May 5;45(5):329-37. Epub 2015 Oct 5.

Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland.

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http://dx.doi.org/10.1111/jop.12372DOI Listing
May 2016

Integrated clinical, whole-genome, and transcriptome analysis of multisampled lethal metastatic prostate cancer.

Cold Spring Harb Mol Case Stud 2016 May;2(3):a000752

Prostate Cancer Research Center, Institute of Biosciences and Medical Technology, BioMediTech, University of Tampere and Fimlab Laboratories, Tampere University Hospital, FI-33014 Tampere, Finland;

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http://dx.doi.org/10.1101/mcs.a000752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853517PMC
May 2016

Statin use and risk of disease recurrence and death after radical prostatectomy.

Prostate 2016 Apr 22;76(5):469-78. Epub 2015 Dec 22.

School of Medicine, University of Tampere, Tampere, Finland.

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http://dx.doi.org/10.1002/pros.23138DOI Listing
April 2016

Feature-based analysis of mouse prostatic intraepithelial neoplasia in histological tissue sections.

J Pathol Inform 2016 29;7. Epub 2016 Jan 29.

Institute of Biosciences and Medical Technology - BioMediTech, University of Tampere, Tampere, Finland; Fimlab Laboratories, Tampere University Hospital, Tampere, Finland.

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http://dx.doi.org/10.4103/2153-3539.175378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763506PMC
March 2016

Transcriptome Sequencing Reveals PCAT5 as a Novel ERG-Regulated Long Noncoding RNA in Prostate Cancer.

Cancer Res 2015 Oct 17;75(19):4026-31. Epub 2015 Aug 17.

Department of Signal Processing, Tampere University of Technology, Tampere, Finland. Institute of Biosciences and Medical Technology-BioMediTech, University of Tampere, Tampere, Finland.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-0217DOI Listing
October 2015

Epigenetically altered miR-193b targets cyclin D1 in prostate cancer.

Cancer Med 2015 Sep 1;4(9):1417-25. Epub 2015 Jul 1.

Institute of Biosciences and Medical Technology - BioMediTech, University of Tampere, Tampere, Finland.

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http://dx.doi.org/10.1002/cam4.486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567026PMC
September 2015

CIP2A is a candidate therapeutic target in clinically challenging prostate cancer cell populations.

Oncotarget 2015 Aug;6(23):19661-70

Prostate Cancer Research Center (PCRC), Institute of Biosciences and Medical Technology (BioMediTech), University of Tampere and Tampere University Hospital, Tampere, Finland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637312PMC
http://dx.doi.org/10.18632/oncotarget.3875DOI Listing
August 2015

Construction of therapeutically relevant human prostate epithelial fate map by utilising miRNA and mRNA microarray expression data.

Br J Cancer 2015 Aug 23;113(4):611-5. Epub 2015 Jul 23.

1] Department of Biology, YCR Cancer Research Unit, University of York, York YO10 5DD, North Yorkshire, UK [2] Department of Urology, Castle Hill Hospital, Cottingham HU16 5JQ, East Yorkshire, UK.

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http://dx.doi.org/10.1038/bjc.2015.262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647689PMC
August 2015

MiR-1247-5p is overexpressed in castration resistant prostate cancer and targets MYCBP2.

Prostate 2015 Jun 1;75(8):798-805. Epub 2015 Mar 1.

Prostate Cancer Research Center, Institute of Biosciences and Medical Technology-BioMediTech and Fimlab Laboratories, University of Tampere and Tampere University Hospital, Tampere, Finland.

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http://dx.doi.org/10.1002/pros.22961DOI Listing
June 2015

MicroRNA expression profile of primary prostate cancer stem cells as a source of biomarkers and therapeutic targets.

Eur Urol 2015 Jan 16;67(1):7-10. Epub 2014 Sep 16.

YCR Cancer Research Unit, Department of Biology, University of York, York, North Yorkshire, UK; Hull York Medical School, University of Hull, Hull, East Yorkshire, UK. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2014.09.005DOI Listing
January 2015

Prevalence and prognostic significance of TMPRSS2-ERG gene fusion in lymph node positive prostate cancers.

Prostate 2014 Dec 22;74(16):1647-54. Epub 2014 Sep 22.

Institute of Pathology, University of Bern, Switzerland.

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http://dx.doi.org/10.1002/pros.22882DOI Listing
December 2014

A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer.

Authors:
Ali Amin Al Olama Zsofia Kote-Jarai Sonja I Berndt David V Conti Fredrick Schumacher Ying Han Sara Benlloch Dennis J Hazelett Zhaoming Wang Ed Saunders Daniel Leongamornlert Sara Lindstrom Sara Jugurnauth-Little Tokhir Dadaev Malgorzata Tymrakiewicz Daniel O Stram Kristin Rand Peggy Wan Alex Stram Xin Sheng Loreall C Pooler Karen Park Lucy Xia Jonathan Tyrer Laurence N Kolonel Loic Le Marchand Robert N Hoover Mitchell J Machiela Merideth Yeager Laurie Burdette Charles C Chung Amy Hutchinson Kai Yu Chee Goh Mahbubl Ahmed Koveela Govindasami Michelle Guy Teuvo L J Tammela Anssi Auvinen Tiina Wahlfors Johanna Schleutker Tapio Visakorpi Katri A Leinonen Jianfeng Xu Markus Aly Jenny Donovan Ruth C Travis Tim J Key Afshan Siddiq Federico Canzian Kay-Tee Khaw Atsushi Takahashi Michiaki Kubo Paul Pharoah Nora Pashayan Maren Weischer Borge G Nordestgaard Sune F Nielsen Peter Klarskov Martin Andreas Røder Peter Iversen Stephen N Thibodeau Shannon K McDonnell Daniel J Schaid Janet L Stanford Suzanne Kolb Sarah Holt Beatrice Knudsen Antonio Hurtado Coll Susan M Gapstur W Ryan Diver Victoria L Stevens Christiane Maier Manuel Luedeke Kathleen Herkommer Antje E Rinckleb Sara S Strom Curtis Pettaway Edward D Yeboah Yao Tettey Richard B Biritwum Andrew A Adjei Evelyn Tay Ann Truelove Shelley Niwa Anand P Chokkalingam Lisa Cannon-Albright Cezary Cybulski Dominika Wokołorczyk Wojciech Kluźniak Jong Park Thomas Sellers Hui-Yi Lin William B Isaacs Alan W Partin Hermann Brenner Aida Karina Dieffenbach Christa Stegmaier Constance Chen Edward L Giovannucci Jing Ma Meir Stampfer Kathryn L Penney Lorelei Mucci Esther M John Sue A Ingles Rick A Kittles Adam B Murphy Hardev Pandha Agnieszka Michael Andrzej M Kierzek William Blot Lisa B Signorello Wei Zheng Demetrius Albanes Jarmo Virtamo Stephanie Weinstein Barbara Nemesure John Carpten Cristina Leske Suh-Yuh Wu Anselm Hennis Adam S Kibel Benjamin A Rybicki Christine Neslund-Dudas Ann W Hsing Lisa Chu Phyllis J Goodman Eric A Klein S Lilly Zheng Jyotsna Batra Judith Clements Amanda Spurdle Manuel R Teixeira Paula Paulo Sofia Maia Chavdar Slavov Radka Kaneva Vanio Mitev John S Witte Graham Casey Elizabeth M Gillanders Daniella Seminara Elio Riboli Freddie C Hamdy Gerhard A Coetzee Qiyuan Li Matthew L Freedman David J Hunter Kenneth Muir Henrik Gronberg David E Neal Melissa Southey Graham G Giles Gianluca Severi Michael B Cook Hidewaki Nakagawa Fredrik Wiklund Peter Kraft Stephen J Chanock Brian E Henderson Douglas F Easton Rosalind A Eeles Christopher A Haiman

Nat Genet 2014 Oct 14;46(10):1103-9. Epub 2014 Sep 14.

1] Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. [2] Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA. [3].

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http://dx.doi.org/10.1038/ng.3094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383163PMC
October 2014

DOT1L-HES6 fusion drives androgen independent growth in prostate cancer.

EMBO Mol Med 2014 Sep;6(9):1121-3

Institute of Biosciences and Medical Technology, Tampere, Finland.

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http://dx.doi.org/10.15252/emmm.201404210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197859PMC
September 2014

Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes.

Science 2014 Aug;345(6196):1251343

Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.

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http://dx.doi.org/10.1126/science.1251343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380235PMC
August 2014

Mapping of the chromosomal amplification 1p21-22 in bladder cancer.

BMC Res Notes 2014 Aug 18;7:547. Epub 2014 Aug 18.

Prostate Cancer Research Center, Institute of Biosciences and Medical Technology - BioMediTech, University of Tampere and Tampere University Hospital, Tampere, Finland.

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http://dx.doi.org/10.1186/1756-0500-7-547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143550PMC
August 2014

Long noncoding RNA in prostate, bladder, and kidney cancer.

Eur Urol 2014 Jun 14;65(6):1140-51. Epub 2013 Dec 14.

Department of Experimental Therapeutics and Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USA; Center for RNA Interference and Non-Coding RNAs, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1016/j.eururo.2013.12.003DOI Listing
June 2014

Hypermethylation of the GABRE~miR-452~miR-224 promoter in prostate cancer predicts biochemical recurrence after radical prostatectomy.

Clin Cancer Res 2014 Apr;20(8):2169-81

Authors' Affiliations: Departments of Molecular Medicine and Urology and Institute of Pathology, Aarhus University Hospital, Aarhus, Denmark; Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland; Department of Urology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany; Institute of Biomedical Technology and BioMediTech, University of Tampere and Tampere University Hospital, Tampere, Finland; Departments of Oncology and Pathology and Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-13-2642DOI Listing
April 2014

A prostate cancer susceptibility allele at 6q22 increases RFX6 expression by modulating HOXB13 chromatin binding.

Nat Genet 2014 Feb 5;46(2):126-35. Epub 2014 Jan 5.

1] Biocenter Oulu, University of Oulu, Oulu, Finland. [2] Department of Medical Biochemistry and Molecular Biology, Institute of Biomedicine, University of Oulu, Oulu, Finland.

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http://dx.doi.org/10.1038/ng.2862DOI Listing
February 2014

USP22 regulates oncogenic signaling pathways to drive lethal cancer progression.

Cancer Res 2014 Jan 6;74(1):272-86. Epub 2013 Nov 6.

Authors' Affiliations: Departments of Cancer Biology, Urology, Radiation Oncology, Pathology, and Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania; Sidney Kimmel Comprehensive Cancer Center; Department of Pathology, Johns Hopkins University, Baltimore, Maryland; and Institute of Biomedical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-1954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947329PMC
January 2014

Loss of PTEN is associated with aggressive behavior in ERG-positive prostate cancer.

Cancer Epidemiol Biomarkers Prev 2013 Dec 1;22(12):2333-44. Epub 2013 Oct 1.

Authors' Affiliations: Institute of Biomedical Technology and Institute of Signal Processing, Prostate Cancer Research Center, BioMediTech, Department of Urology, School of Medicine, University of Tampere and Tampere University Hospital, Tampere, Finland; Departments of Pathology and Urology, Jikei University School of Medicine, Minato-ku, Tokyo; Department of Urology, Toho University Sakura Medical Center, Sakura, Chiba, Japan; Departments of Pathology and Urology, Johns Hopkins University, Baltimore, Maryland; and Department of Clinical Chemistry, Helsinki University Central Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1158/1055-9965.EPI-13-0333-TDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086660PMC
December 2013

Chk1 targeting reactivates PP2A tumor suppressor activity in cancer cells.

Cancer Res 2013 Nov 26;73(22):6757-69. Epub 2013 Sep 26.

Authors' Affiliations: Institute of Biomedical Technology and BioMediTech, University of Tampere and Tampere University Hospital; Tampere Graduate Program in Biomedicine and Biotechnology (TGPBB), University of Tampere, Tampere; Turku Centre for Biotechnology, University of Turku and Åbo Akademi University; Department of Pathology, University of Turku; Turku Doctoral Program of Biomedical Sciences (TuBS), Turku; Department of Pathology, HUSLAB and Haartman Institute, Helsinki University, Central Hospital and University of Helsinki; University of Helsinki Institute of Biomedicine and Genome-Scale Biology Research Program; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland; Karlsruhe Institute of Technology, Campus North, Institute of Toxicology and Genetics, Karlsruhe, Germany; Adult Cancer Program, Lowy Cancer Centre and Prince of Wales Hospital, UNSW Medicine, University of New South Wales, Sydney, Australia; Department of Medical Biology and Genetics, Faculty of Medicine, Akdeniz University, Antalya, Turkey; Division of Oncology, Children's Hospital of Philadelphia; and Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-1002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870284PMC
November 2013

The mutational landscape of prostate cancer.

Eur Urol 2013 Oct 18;64(4):567-76. Epub 2013 May 18.

Department of Urology, Weill Medical College of Cornell University, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/j.eururo.2013.05.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342117PMC
October 2013

DNA methylation signatures for prediction of biochemical recurrence after radical prostatectomy of clinically localized prostate cancer.

J Clin Oncol 2013 Sep 5;31(26):3250-8. Epub 2013 Aug 5.

Christa Haldrup, Kamilla Mundbjerg, Else Marie Vestergaard, Philippe Lamy, Michael Borre, Søren Høyer, Torben F. Ørntoft, and Karina D. Sørensen, Aarhus University Hospital, Aarhus, Denmark; Peter Wild, University Hospital Zurich, Zurich, Switzerland; Wolfgang A. Schulz and Christian Arsov, Heinrich Heine University, Düsseldorf, Germany; and Tapio Visakorpi, University of Tampere and Tampere University Hospital, Tampere, Finland.

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http://jco.ascopubs.org/content/early/2013/08/05/JCO.2012.47
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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2012.47.1847
Publisher Site
http://dx.doi.org/10.1200/JCO.2012.47.1847DOI Listing
September 2013

HOXB13 G84E mutation in Finland: population-based analysis of prostate, breast, and colorectal cancer risk.

Cancer Epidemiol Biomarkers Prev 2013 Mar 4;22(3):452-60. Epub 2013 Jan 4.

Johanna Schleutker, Medical Biochemistry and Genetics, Institute of Biomedicine, Kiinamyllynkatu 10, FI-20014 University of Turku, Finland.

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http://dx.doi.org/10.1158/1055-9965.EPI-12-1000-TDOI Listing
March 2013

Bcl-2 associated athanogene 5 (Bag5) is overexpressed in prostate cancer and inhibits ER-stress induced apoptosis.

BMC Cancer 2013 Mar 1;13:96. Epub 2013 Mar 1.

Karlsruhe Institute of Technology, Institute of Toxicology and Genetics, Hermann-von-Helmholtz Platz 1, Eggenstein-Leopoldshafen 76344, Germany.

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http://dx.doi.org/10.1186/1471-2407-13-96DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598994PMC
March 2013

Goserelin and bicalutamide treatments alter the expression of microRNAs in the prostate.

Prostate 2013 Jan 5;73(1):101-12. Epub 2012 Jun 5.

Institute of Biomedical Technology and BioMediTech, University of Tampere and Tampere University Hospital, Tampere, Finland.

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http://dx.doi.org/10.1002/pros.22545DOI Listing
January 2013

Expression of ERG oncoprotein is associated with a less aggressive tumor phenotype in Japanese prostate cancer patients.

Pathol Int 2012 Nov;62(11):742-8

Department of Urology, Path Institute of DNA Medicine, Jikei University School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1111/pin.12006DOI Listing
November 2012

The role of genetic markers in the management of prostate cancer.

Eur Urol 2012 Oct 5;62(4):577-87. Epub 2012 Jun 5.

Dana-Farber Cancer Institute, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/j.eururo.2012.05.054DOI Listing
October 2012

Androgen receptor (AR) aberrations in castration-resistant prostate cancer.

Mol Cell Endocrinol 2012 Sep 8;360(1-2):38-43. Epub 2012 Jan 8.

Computational Systems Biology, Tampere University of Technology, Tampere, Finland.

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http://dx.doi.org/10.1016/j.mce.2011.12.019DOI Listing
September 2012

Novel endocrine aspects of prostate cancer.

Authors:
Tapio Visakorpi

Mol Cell Endocrinol 2012 Sep 28;360(1-2):1-2. Epub 2012 Mar 28.

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http://dx.doi.org/10.1016/j.mce.2012.03.015DOI Listing
September 2012

Androgen receptor overexpression alters binding dynamics of the receptor to chromatin and chromatin structure.

Prostate 2012 Aug 27;72(11):1223-32. Epub 2011 Dec 27.

Institute of Biomedical Technology and BioMediTech, University of Tampere and Tampere University Hospital, Tampere, Finland.

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http://dx.doi.org/10.1002/pros.22473DOI Listing
August 2012

Chemical castration and anti-androgens induce differential gene expression in prostate cancer.

J Pathol 2012 Jul 8;227(3):336-45. Epub 2012 May 8.

Institute of Biomedical Technology and BioMediTech, University of Tampere and Tampere University Hospital, Finland.

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http://dx.doi.org/10.1002/path.4027DOI Listing
July 2012

Histone H2B ubiquitin ligases RNF20 and RNF40 in androgen signaling and prostate cancer cell growth.

Mol Cell Endocrinol 2012 Mar 2;350(1):87-98. Epub 2011 Dec 2.

Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.

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http://dx.doi.org/10.1016/j.mce.2011.11.025DOI Listing
March 2012

Overall and worst gleason scores are equally good predictors of prostate cancer progression.

BMC Urol 2011 Oct 6;11:21. Epub 2011 Oct 6.

Institute of Medical Technology, University of Tampere, Tampere University Hospital, Finland.

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http://dx.doi.org/10.1186/1471-2490-11-21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3193164PMC
October 2011

The miR-15a-miR-16-1 locus is homozygously deleted in a subset of prostate cancers.

Genes Chromosomes Cancer 2011 Jul 31;50(7):499-509. Epub 2011 Mar 31.

Institute of Medical Technology, University of Tampere, Tampere University Hospital, Finland.

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http://dx.doi.org/10.1002/gcc.20873DOI Listing
July 2011

Androgen regulation of micro-RNAs in prostate cancer.

Prostate 2011 May 13;71(6):604-14. Epub 2010 Oct 13.

Institute of Medical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland.

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http://dx.doi.org/10.1002/pros.21276DOI Listing
May 2011

MicroRNA in prostate, bladder, and kidney cancer: a systematic review.

Eur Urol 2011 May 1;59(5):671-81. Epub 2011 Feb 1.

Institute for Cancer Studies and Academic Urology Unit, University of Sheffield, Sheffield, UK.

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http://dx.doi.org/10.1016/j.eururo.2011.01.044DOI Listing
May 2011

Activating mutation (V617F) in the tyrosine kinase JAK2 is absent in locally-confined or castration-resistant prostate cancer.

Anal Cell Pathol (Amst) 2010 ;33(2):55-9

Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.3233/ACP-CLO-2010-0534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605774PMC
February 2011

Probabilistic analysis of gene expression measurements from heterogeneous tissues.

Bioinformatics 2010 Oct 14;26(20):2571-7. Epub 2010 Jul 14.

Department of Signal Processing, Tampere University of Technology, Finland.

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http://dx.doi.org/10.1093/bioinformatics/btq406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951082PMC
October 2010

miR-193b is an epigenetically regulated putative tumor suppressor in prostate cancer.

Int J Cancer 2010 Sep;127(6):1363-72

Institute of Medical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland.

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http://dx.doi.org/10.1002/ijc.25162DOI Listing
September 2010

Genetic alterations and changes in expression of histone demethylases in prostate cancer.

Prostate 2010 Jun;70(8):889-98

Institute of Medical Technology, University of Tampere, Tampere, Finland.

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http://dx.doi.org/10.1002/pros.21123DOI Listing
June 2010

Association of SPINK1 expression and TMPRSS2:ERG fusion with prognosis in endocrine-treated prostate cancer.

Clin Cancer Res 2010 May 4;16(10):2845-51. Epub 2010 May 4.

Laboratory of Cancer Genetics, Institute of Medical Technology, University of Tampere and Department of Urology, Tampere University Hospital, Tampere, Finland.

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http://dx.doi.org/10.1158/1078-0432.CCR-09-2505DOI Listing
May 2010

Increased expression of androgen receptor sensitizes prostate cancer cells to low levels of androgens.

Cancer Res 2009 Oct 6;69(20):8141-9. Epub 2009 Oct 6.

Laboratory of Cancer Genetics, Institute of Medical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-0919DOI Listing
October 2009

Methods for identifying and studying genetic alterations in hormone-dependent cancers.

Methods Mol Biol 2009 ;505:263-77

Institute of Medical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland.

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http://link.springer.com/10.1007/978-1-60327-575-0_15
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http://dx.doi.org/10.1007/978-1-60327-575-0_15DOI Listing
February 2009

TCEB1 promotes invasion of prostate cancer cells.

Int J Cancer 2009 Jan;124(1):95-102

Laboratory of Cancer Genetics, Institute of Medical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland.

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http://dx.doi.org/10.1002/ijc.23916DOI Listing
January 2009

Generation of a conditionally replicating adenovirus based on targeted destruction of E1A mRNA by a cell type-specific MicroRNA.

J Virol 2008 Nov 17;82(22):11009-15. Epub 2008 Sep 17.

Department of Virology, Haartman Institute, University of Helsinki, Haartmaninkatu 3 (POB 21), FIN-00014 Helsinki, Finland.

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http://jvi.asm.org/cgi/doi/10.1128/JVI.01608-08
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http://dx.doi.org/10.1128/JVI.01608-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2573287PMC
November 2008

Clusterin is epigenetically regulated in prostate cancer.

Int J Cancer 2008 Oct;123(7):1601-9

Institute of Medical Technology, University of Tampere, and Tampere University Hospital, Tampere, Finland.

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http://dx.doi.org/10.1002/ijc.23658DOI Listing
October 2008

Somatic mutation analysis of MYH11 in breast and prostate cancer.

BMC Cancer 2008 Sep 17;8:263. Epub 2008 Sep 17.

Department of Medical Genetics and Translational Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1186/1471-2407-8-263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562392PMC
September 2008

Androgen regulation of the androgen receptor coregulators.

BMC Cancer 2008 Aug 1;8:219. Epub 2008 Aug 1.

Institute of Medical Technology, University of Tampere and Tampere University Hospital, FI-33014 University of Tampere, Tampere, Finland.

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http://dx.doi.org/10.1186/1471-2407-8-219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518564PMC
August 2008

Statins and prostate cancer prevention: where we are now, and future directions.

Nat Clin Pract Urol 2008 Jul 10;5(7):376-87. Epub 2008 Jun 10.

Department of Epidemiology, School of Public Health, University of Tampere, Tampere, Finland.

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http://dx.doi.org/10.1038/ncpuro1146DOI Listing
July 2008