Publications by authors named "Taosheng Chen"

100Publications

Structural Perspectives of the CYP3A Family and Their Small Molecule Modulators in Drug Metabolism.

Liver Res 2019 Dec 29;3(3-4):132-142. Epub 2019 Aug 29.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1016/j.livres.2019.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418881PMC
December 2019

Toxicoproteomic Profiling of Transgenic Mice Treated with Rifampicin and Isoniazid.

Cells 2020 Jul 9;9(7). Epub 2020 Jul 9.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.3390/cells9071654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407182PMC
July 2020

PXR-mediated idiosyncratic drug-induced liver injury: mechanistic insights and targeting approaches.

Expert Opin Drug Metab Toxicol 2020 Aug 16;16(8):711-722. Epub 2020 Jun 16.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital , Memphis, TN, USA.

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http://dx.doi.org/10.1080/17425255.2020.1779701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429329PMC
August 2020

Mutation of a single amino acid of pregnane X receptor switches an antagonist to agonist by altering AF-2 helix positioning.

Cell Mol Life Sci 2020 Mar 30. Epub 2020 Mar 30.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS 1000, Memphis, TN, 38105-3678, USA.

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http://dx.doi.org/10.1007/s00018-020-03505-yDOI Listing
March 2020

ABCG2 requires a single aromatic amino acid to "clamp" substrates and inhibitors into the binding pocket.

FASEB J 2020 Apr 17;34(4):4890-4903. Epub 2020 Feb 17.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.1096/fj.201902338RRDOI Listing
April 2020

KANSL2 and MBNL3 are regulators of pancreatic ductal adenocarcinoma invasion.

Sci Rep 2020 01 30;10(1):1485. Epub 2020 Jan 30.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, 38105, USA.

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http://dx.doi.org/10.1038/s41598-020-58448-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992758PMC
January 2020

Clobetasol Propionate Is a Heme-Mediated Selective Inhibitor of Human Cytochrome P450 3A5.

J Med Chem 2020 02 22;63(3):1415-1433. Epub 2020 Jan 22.

Department of Chemical Biology and Therapeutics , St. Jude Children's Research Hospital , Memphis , Tennessee 38105-3678 , United States.

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http://dx.doi.org/10.1021/acs.jmedchem.9b02067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087482PMC
February 2020

CITCO Directly Binds to and Activates Human Pregnane X Receptor.

Mol Pharmacol 2020 03 27;97(3):180-190. Epub 2019 Dec 27.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee

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http://dx.doi.org/10.1124/mol.119.118513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978709PMC
March 2020

A high-throughput screening identifies histone deacetylase inhibitors as therapeutic agents against medulloblastoma.

Exp Hematol Oncol 2019 15;8:30. Epub 2019 Nov 15.

1Section of Epidemiology & Population Sciences, Department of Medicine, Baylor College of Medicine, Houston, TX USA.

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http://dx.doi.org/10.1186/s40164-019-0153-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858705PMC
November 2019

Strategies for developing pregnane X receptor antagonists: Implications from metabolism to cancer.

Med Res Rev 2020 May 28;40(3):1061-1083. Epub 2019 Nov 28.

Department of Chemical Biology and Therapeutics, St Jude Children's Research Hospital, Memphis, Tennessee.

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http://dx.doi.org/10.1002/med.21648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7166136PMC
May 2020

High-Throughput Imaging of PPIX Using Confocal Microscopy.

Methods Mol Biol 2019 ;1966:137-149

St. Jude Children's Research Hospital, Memphis, TN, USA.

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http://link.springer.com/10.1007/978-1-4939-9195-2_11
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http://dx.doi.org/10.1007/978-1-4939-9195-2_11DOI Listing
August 2019

Discovering Anti-cancer Immune Enhancers in a Miniaturized Immune-Tumor Microenvironment.

Cell Chem Biol 2019 03;26(3):314-316

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S24519456193008
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http://dx.doi.org/10.1016/j.chembiol.2019.03.004DOI Listing
March 2019

Genome-wide CRISPR screen reveals PSMA6 to be an essential gene in pancreatic cancer cells.

BMC Cancer 2019 Mar 21;19(1):253. Epub 2019 Mar 21.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.1186/s12885-019-5455-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429770PMC
March 2019

Drug discovery technologies to identify and characterize modulators of the pregnane X receptor and the constitutive androstane receptor.

Drug Discov Today 2019 03 4;24(3):906-915. Epub 2019 Feb 4.

Department of Chemical Biology & Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA. Electronic address:

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http://dx.doi.org/10.1016/j.drudis.2019.01.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421094PMC
March 2019

RNA interference screen identifies NAA10 as a regulator of PXR transcription.

Biochem Pharmacol 2019 02 16;160:92-109. Epub 2018 Dec 16.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, United States; Integrated Biomedical Sciences Program, University of Tennessee Health Science Center, Memphis, TN 38163, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2018.12.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361121PMC
February 2019

Correction to: Tetraspanin-enriched microdomains regulate digitation junctions.

Cell Mol Life Sci 2018 11;75(21):4077

Stephenson Cancer Center and Department of Physiology, University of Oklahoma Health Sciences Center, BRC Building West Room 1474, 975 N.E. 10th Street, Oklahoma City, OK, 73104, USA.

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http://dx.doi.org/10.1007/s00018-018-2909-6DOI Listing
November 2018

Intrinsic Instability of BOK Enables Membrane Permeabilization in Apoptosis.

Cell Rep 2018 05;23(7):2083-2094.e6

Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.04.060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6500462PMC
May 2018

A current structural perspective on PXR and CAR in drug metabolism.

Expert Opin Drug Metab Toxicol 2018 Jun 30;14(6):635-647. Epub 2018 May 30.

a Department of Chemical Biology and Therapeutics , St. Jude Children's Research Hospital , Memphis , TN , USA.

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http://dx.doi.org/10.1080/17425255.2018.1476488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002932PMC
June 2018

CINPA1 binds directly to constitutive androstane receptor and inhibits its activity.

Biochem Pharmacol 2018 06 31;152:211-223. Epub 2018 Mar 31.

Department of Chemical Biology & Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA; Integrated Biomedical Sciences Program, University of Tennessee Health Science Center, 920 Madison Avenue, Memphis, TN 38163, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2018.03.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960625PMC
June 2018

Tetraspanin-enriched microdomains regulate digitation junctions.

Cell Mol Life Sci 2018 09 27;75(18):3423-3439. Epub 2018 Mar 27.

Stephenson Cancer Center and Department of Physiology, University of Oklahoma Health Sciences Center, BRC Building West Room 1474, 975 N.E. 10th Street, Oklahoma City, OK, 73104, USA.

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http://dx.doi.org/10.1007/s00018-018-2803-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615572PMC
September 2018

Using TR-FRET to Investigate Protein-Protein Interactions: A Case Study of PXR-Coregulator Interaction.

Adv Protein Chem Struct Biol 2018 31;110:31-63. Epub 2017 Aug 31.

St. Jude Children's Research Hospital, Memphis, TN, United States. Electronic address:

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http://dx.doi.org/10.1016/bs.apcsb.2017.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815392PMC
June 2019

HNRNPH1 is required for rhabdomyosarcoma cell growth and survival.

Oncogenesis 2018 Jan 24;7(1). Epub 2018 Jan 24.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.1038/s41389-017-0024-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833419PMC
January 2018

Hepatotoxicity of Herbal Supplements Mediated by Modulation of Cytochrome P450.

Int J Mol Sci 2017 Nov 8;18(11). Epub 2017 Nov 8.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.3390/ijms18112353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713322PMC
November 2017

PXR: More Than Just a Master Xenobiotic Receptor.

Mol Pharmacol 2018 02 7;93(2):119-127. Epub 2017 Nov 7.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee

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http://dx.doi.org/10.1124/mol.117.110155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767680PMC
February 2018

High-Throughput Screening Identifies 1,4,5-Substituted 1,2,3-Triazole Analogs as Potent and Specific Antagonists of Pregnane X Receptor.

Assay Drug Dev Technol 2017 Dec 7;15(8):383-394. Epub 2017 Nov 7.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital , Memphis, Tennessee.

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http://dx.doi.org/10.1089/adt.2017.809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731549PMC
December 2017

SPA70 is a potent antagonist of human pregnane X receptor.

Nat Commun 2017 09 29;8(1):741. Epub 2017 Sep 29.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, 38105-3678, USA.

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http://dx.doi.org/10.1038/s41467-017-00780-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622171PMC
September 2017

Transcription factor ZNF148 is a negative regulator of human muscle differentiation.

Sci Rep 2017 08 15;7(1):8138. Epub 2017 Aug 15.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

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http://dx.doi.org/10.1038/s41598-017-08267-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557752PMC
August 2017

Ventromorphins: A New Class of Small Molecule Activators of the Canonical BMP Signaling Pathway.

ACS Chem Biol 2017 09 29;12(9):2436-2447. Epub 2017 Aug 29.

Departments of Hematology, ‡Chemical Biology and Therapeutics, §Tumor Cell Biology, and ∥Computational Biology, St. Jude Children's Research Hospital , Memphis, Tennessee, United States.

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http://dx.doi.org/10.1021/acschembio.7b00527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676454PMC
September 2017

Differential Regulation of CYP3A4 and CYP3A5 and its Implication in Drug Discovery.

Curr Drug Metab 2017 ;18(12):1095-1105

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.2174/1389200218666170531112038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709240PMC
September 2018

Glucose-dependent regulation of pregnane X receptor is modulated by AMP-activated protein kinase.

Sci Rep 2017 04 24;7:46751. Epub 2017 Apr 24.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1038/srep46751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402287PMC
April 2017

variants: the impact on drug metabolism and therapeutic responses.

Acta Pharm Sin B 2016 Sep 27;6(5):441-449. Epub 2016 Jul 27.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Integrated Biomedical Sciences Program, University of Tennessee Health Science Center, Memphis, TN 38163, USA.

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http://dx.doi.org/10.1016/j.apsb.2016.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045535PMC
September 2016

Identification and Characterization of CINPA1 Metabolites Facilitates Structure-Activity Studies of the Constitutive Androstane Receptor.

Drug Metab Dispos 2016 11 12;44(11):1759-1770. Epub 2016 Aug 12.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee

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http://dx.doi.org/10.1124/dmd.116.071993DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5074473PMC
November 2016

Regulation of PXR and CAR by protein-protein interaction and signaling crosstalk.

Expert Opin Drug Metab Toxicol 2016 Sep 23;12(9):997-1010. Epub 2016 Jun 23.

a Department of Chemical Biology and Therapeutics , St. Jude Children's Research Hospital , Memphis , TN , USA.

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http://dx.doi.org/10.1080/17425255.2016.1201069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992434PMC
September 2016

Development of Cell-Based High-Throughput Chemical Screens for Protection Against Cisplatin-Induced Ototoxicity.

Methods Mol Biol 2016 ;1427:419-30

Department of Developmental Neurobiology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA.

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http://dx.doi.org/10.1007/978-1-4939-3615-1_22DOI Listing
December 2017

The orphan nuclear receptor NR4A2 is part of a p53-microRNA-34 network.

Sci Rep 2016 04 28;6:25108. Epub 2016 Apr 28.

Department of Chemical Biology &Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

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http://dx.doi.org/10.1038/srep25108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848494PMC
April 2016

Small-molecule modulators of PXR and CAR.

Biochim Biophys Acta 2016 09 24;1859(9):1141-1154. Epub 2016 Feb 24.

Department of Chemical Biology and Therapeutics, 262 Danny Thomas Place, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbagrm.2016.02.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975625PMC
September 2016

Tryptophan 299 is a conserved residue of human pregnane X receptor critical for the functional consequence of ligand binding.

Biochem Pharmacol 2016 Mar 18;104:131-8. Epub 2016 Feb 18.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2016.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778391PMC
March 2016

Regulation of Nuclear Receptor Nur77 by miR-124.

PLoS One 2016 3;11(2):e0148433. Epub 2016 Feb 3.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0148433PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4739595PMC
July 2016

Development of CINPA1 analogs as novel and potent inverse agonists of constitutive androstane receptor.

Eur J Med Chem 2016 Jan 15;108:505-528. Epub 2015 Dec 15.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Mail Stop 1000, Memphis, TN 38105, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2015.12.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724233PMC
January 2016

Serine 350 of human pregnane X receptor is crucial for its heterodimerization with retinoid X receptor alpha and transactivation of target genes in vitro and in vivo.

Biochem Pharmacol 2015 Aug 25;96(4):357-68. Epub 2015 Jun 25.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Integrated Biomedical Sciences Program, University of Tennessee Health Science Center, Memphis, TN 38163, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2015.06.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526351PMC
August 2015

Small-molecule modulators of the constitutive androstane receptor.

Expert Opin Drug Metab Toxicol 2015 Jul 15;11(7):1099-114. Epub 2015 May 15.

Postdoctoral fellow, St. Jude Children's Research Hospital, Department of Chemical Biology and Therapeutics , 262 Danny Thomas Place, Memphis, TN 38105 , USA.

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http://dx.doi.org/10.1517/17425255.2015.1043887DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4469626PMC
July 2015

CINPA1 is an inhibitor of constitutive androstane receptor that does not activate pregnane X receptor.

Mol Pharmacol 2015 May 11;87(5):878-89. Epub 2015 Mar 11.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee

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http://dx.doi.org/10.1124/mol.115.097782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407736PMC
May 2015

PRL-3 mediates the protein maturation of ULBP2 by regulating the tyrosine phosphorylation of HSP60.

J Immunol 2015 Mar 16;194(6):2930-41. Epub 2015 Feb 16.

Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN 38105; Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38103

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http://dx.doi.org/10.4049/jimmunol.1400817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355089PMC
March 2015

A high-throughput screen reveals new small-molecule activators and inhibitors of pantothenate kinases.

J Med Chem 2015 Feb 21;58(3):1563-8. Epub 2015 Jan 21.

Department of Chemical Biology and Therapeutics, ‡Department of Infectious Diseases, St. Jude Children's Research Hospital , 262 Danny Thomas Place, Memphis, Tennessee 38105, United States.

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http://dx.doi.org/10.1021/jm501585qDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357395PMC
February 2015

Mg2+/Mn2+-dependent phosphatase 1A is involved in regulating pregnane X receptor-mediated cytochrome p450 3A4 gene expression.

Drug Metab Dispos 2015 Mar 5;43(3):385-91. Epub 2015 Jan 5.

Department of Anatomy, Physiology, and Pharmacology (S.R.P., P.C.F., K.L.A.) and Department of Nutrition, Dietetics, and Hospitality Management (J.R.B., S.D.R.), Auburn University, Auburn, Alabama; Department of Chemistry (T.G.), Auburn University at Montgomery, Montgomery, Alabama; Department of Chemical Biology and Therapeutics (T.C.), St. Jude Children's Research Hospital, Memphis, Tennessee; and Department of Pharmacology, Toxicology, and Therapeutics (U.A.), University of Kansas, Kansas City, Kansas.

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http://dx.doi.org/10.1124/dmd.114.062083DOI Listing
March 2015

Targeting xenobiotic receptors PXR and CAR in human diseases.

Drug Discov Today 2015 May 20;20(5):618-28. Epub 2014 Nov 20.

Department of Chemical Biology and Therapeutics, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA. Electronic address:

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http://dx.doi.org/10.1016/j.drudis.2014.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433851PMC
May 2015

The interplay of NR4A receptors and the oncogene-tumor suppressor networks in cancer.

Cell Signal 2015 Feb 15;27(2):257-66. Epub 2014 Nov 15.

Department of Chemical Biology & Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS 1000, Memphis, TN 38105, USA; Integrated Biomedical Sciences Program, University of Tennessee Health Science Center, 920 Madison Avenue, Suite 407, Memphis, TN 38163, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2014.11.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276441PMC
February 2015

Pregnane X receptor and drug-induced liver injury.

Expert Opin Drug Metab Toxicol 2014 Nov 25;10(11):1521-32. Epub 2014 Sep 25.

St. Jude Children's Research Hospital, Department of Chemical Biology and Therapeutics , 262 Danny Thomas Place, Memphis, TN 38105 , USA.

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http://dx.doi.org/10.1517/17425255.2014.963555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198438PMC
November 2014

Thiazide-like diuretic drug metolazone activates human pregnane X receptor to induce cytochrome 3A4 and multidrug-resistance protein 1.

Biochem Pharmacol 2014 Nov 30;92(2):389-402. Epub 2014 Aug 30.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Mail Stop 1000, 262 Danny Thomas Place, Memphis, TN 38105-3678, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2014.08.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252478PMC
November 2014

Development of BODIPY FL vindoline as a novel and high-affinity pregnane X receptor fluorescent probe.

Bioconjug Chem 2014 Sep 18;25(9):1664-77. Epub 2014 Aug 18.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital , 262 Danny Thomas Place, Mail Stop 1000, Memphis, Tennessee 38105, United States.

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http://dx.doi.org/10.1021/bc5002856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166032PMC
September 2014

Identification of trisubstituted-pyrazol carboxamide analogs as novel and potent antagonists of farnesoid X receptor.

Bioorg Med Chem 2014 Jun 16;22(11):2919-38. Epub 2014 Apr 16.

Department of Chemical Biology & Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2014.04.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147378PMC
June 2014

Tissue-specific regulation of pregnane X receptor in cancer development and therapy.

Cell Biosci 2014 Apr 1;4(1):17. Epub 2014 Apr 1.

Department of Chemical Biology and Therapeutics, St, Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.

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http://cellandbioscience.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/2045-3701-4-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237984PMC
April 2014

High-throughput screening reveals alsterpaullone, 2-cyanoethyl as a potent p27Kip1 transcriptional inhibitor.

PLoS One 2014 19;9(3):e91173. Epub 2014 Mar 19.

Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0091173PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960108PMC
December 2014

Stability of the human pregnane X receptor is regulated by E3 ligase UBR5 and serine/threonine kinase DYRK2.

Biochem J 2014 Apr;459(1):193-203

*Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, U.S.A.

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http://biochemj.org/lookup/doi/10.1042/BJ20130558
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http://dx.doi.org/10.1042/BJ20130558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959618PMC
April 2014

Modulation of NKG2D ligand expression and metastasis in tumors by spironolactone via RXRγ activation.

J Exp Med 2013 Nov 4;210(12):2675-92. Epub 2013 Nov 4.

Department of Bone Marrow Transplantation and Cellular Therapy; 2 Department of Chemical Biology & Therapeutics; and 3 Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105.

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http://dx.doi.org/10.1084/jem.20122292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832934PMC
November 2013

Identification and characterization of phosphorylation sites within the pregnane X receptor protein.

Biochem Pharmacol 2014 Jan 30;87(2):360-70. Epub 2013 Oct 30.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2013.10.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947193PMC
January 2014

A vinblastine fluorescent probe for pregnane X receptor in a time-resolved fluorescence resonance energy transfer assay.

Anal Biochem 2013 Dec 14;443(2):252-60. Epub 2013 Sep 14.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1016/j.ab.2013.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825844PMC
December 2013

Differential regulation of CYP3A4 promoter activity by a new class of natural product derivatives binding to pregnane X receptor.

Biochem Pharmacol 2013 Sep 5;86(6):824-35. Epub 2013 Aug 5.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1016/j.bcp.2013.07.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777815PMC
September 2013

Modulation of xenobiotic receptors by steroids.

Molecules 2013 Jun 24;18(7):7389-406. Epub 2013 Jun 24.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.

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http://dx.doi.org/10.3390/molecules18077389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777271PMC
June 2013

Piperine activates human pregnane X receptor to induce the expression of cytochrome P450 3A4 and multidrug resistance protein 1.

Toxicol Appl Pharmacol 2013 Oct 22;272(1):96-107. Epub 2013 May 22.

Department of Chemical Biology & Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1016/j.taap.2013.05.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775940PMC
October 2013

Development of time resolved fluorescence resonance energy transfer-based assay for FXR antagonist discovery.

Bioorg Med Chem 2013 Jul 7;21(14):4266-78. Epub 2013 May 7.

Department of Diabetes, Endocrinology and Metabolism, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA.

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http://dx.doi.org/10.1016/j.bmc.2013.04.069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691817PMC
July 2013

A timetable organizer for the planning and implementation of screenings in manual or semi-automation mode.

J Biomol Screen 2013 Sep 7;18(8):938-42. Epub 2013 May 7.

High-Throughput Screening Center, Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.1177/1087057113487556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740013PMC
September 2013

Tumor suppressor protein p53 negatively regulates human pregnane X receptor activity.

Mol Pharmacol 2013 Jun 27;83(6):1229-36. Epub 2013 Mar 27.

Department of Chemical Biology & Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105-3678, USA.

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http://dx.doi.org/10.1124/mol.113.085092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657101PMC
June 2013

Cyclin-dependent kinase 4 phosphorylates and positively regulates PAX3-FOXO1 in human alveolar rhabdomyosarcoma cells.

PLoS One 2013 28;8(2):e58193. Epub 2013 Feb 28.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0058193PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585270PMC
August 2013

GUItars: a GUI tool for analysis of high-throughput RNA interference screening data.

PLoS One 2012 20;7(11):e49386. Epub 2012 Nov 20.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0049386PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502531PMC
May 2013

Role of CAR and PXR in xenobiotic sensing and metabolism.

Expert Opin Drug Metab Toxicol 2012 Jul 3;8(7):803-17. Epub 2012 May 3.

St. Jude Children's Research Hospital, Department of Chemical Biology and Therapeutics, 262 Danny Thomas Place, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1517/17425255.2012.685237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3593589PMC
July 2012

Carnitine palmitoyltransferase 1A (CPT1A): a transcriptional target of PAX3-FKHR and mediates PAX3-FKHR-dependent motility in alveolar rhabdomyosarcoma cells.

BMC Cancer 2012 Apr 25;12:154. Epub 2012 Apr 25.

Department of Chemical Biology and Therapeutics, St, Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1186/1471-2407-12-154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3453510PMC
April 2012

PAX3-FKHR regulates the expression of pleiotrophin to mediate motility in alveolar rhabdomyosarcoma cells.

J Can Res Updates 2012 Jan;1(1)

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.6000/1929-2279.2012.01.01.09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859525PMC
January 2012

A tea catechin, epigallocatechin-3-gallate, is a unique modulator of the farnesoid X receptor.

Toxicol Appl Pharmacol 2012 Jan 4;258(2):268-74. Epub 2011 Dec 4.

Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA.

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http://dx.doi.org/10.1016/j.taap.2011.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3259191PMC
January 2012

Development of a pterin-based fluorescent probe for screening dihydropteroate synthase.

Bioconjug Chem 2011 Oct 30;22(10):2110-7. Epub 2011 Sep 30.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, United States.

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http://dx.doi.org/10.1021/bc200346eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384522PMC
October 2011

An automated approach to efficiently reformat a large collection of compounds.

Curr Chem Genomics 2011 22;5:42-7. Epub 2011 Jul 22.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.

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http://dx.doi.org/10.2174/1875397301105010042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145259PMC
November 2011

A high-content screen identifies inhibitors of nuclear export of forkhead transcription factors.

J Biomol Screen 2011 Apr;16(4):394-404

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1177/1087057110397889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536487PMC
April 2011

Structure-activity relationships of substituted 1-pyridyl-2-phenyl-1,2-ethanediones: potent, selective carboxylesterase inhibitors.

J Med Chem 2010 Dec 24;53(24):8709-15. Epub 2010 Nov 24.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1021/jm101101qDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022373PMC
December 2010

Development of cell-based high-throughput assays for the identification of inhibitors of receptor activator of nuclear factor-kappa B signaling.

Assay Drug Dev Technol 2011 Feb 4;9(1):40-9. Epub 2010 Nov 4.

Department of Pathology, University of Alabama at Birmingham, 1670 University Blvd., Birmingham, AL 35294, USA.

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http://dx.doi.org/10.1089/adt.2010.0307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033204PMC
February 2011

Overcoming drug resistance by regulating nuclear receptors.

Authors:
Taosheng Chen

Adv Drug Deliv Rev 2010 Oct 4;62(13):1257-64. Epub 2010 Aug 4.

Department of Chemical Biology & Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1016/j.addr.2010.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991604PMC
October 2010