Publications by authors named "Tao Jing"

574 Publications

Critical Role of Sc Substitution in Modulating Ferroelectricity in Multiferroic LuFeO.

Nano Lett 2021 Jul 20. Epub 2021 Jul 20.

School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China.

Understanding how individual dopants or substitutional atoms interact with host lattices enables us to manipulate, control, and improve the functionality of materials. However, because of the intimate coupling among various degrees of freedom in multiferroics, the atomic-scale influence of individual foreign atoms has remained elusive. Here, we unravel the critical roles of individual Sc substitutional atoms in modulating ferroelectricity at the atomic scale of typical multiferroics, LuScFeO, by combining advanced microscopy and theoretical studies. Atomic variations in polar displacement of intriguing topological vortex domains stabilized by Sc substitution are directly correlated with Sc atom-mediated local chemical and electronic fluctuations. The local FeO trimerization magnitude and Lu/Sc-O hybridization strength are found to be significantly reinforced by Sc, clarifying the origin of the strong dependence of improper ferroelectricity on Sc content. This study could pave the way for correlating dopant-regulated atomic-scale local structures with global properties to engineer emergent functionalities of numerous chemically doped functional materials.
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http://dx.doi.org/10.1021/acs.nanolett.1c02123DOI Listing
July 2021

Prevalence and risk factors of diabetes among adults aged 45 years or older in China: A national cross-sectional study.

Endocrinol Diabetes Metab 2021 Jul 24;4(3):e00265. Epub 2021 May 24.

School of Public Health Peking University Beijing China.

Background: Although there is preponderance of literature on disease burden of diabetes in developed countries, limited investigations have been conducted in less developed regions including China. This study aimed to explore the current prevalence and risk factors for diabetes, pre-diabetes, awareness, treatment and control of diabetes in China.

Methods: We included 12,458 adults from the China Health and Retirement Longitudinal Study. We estimated prevalence of diabetes and pre-diabetes in the overall sample and by socio-demographics. Bivariate associations of diabetes, pre-diabetes, awareness, control and treatment of diabetes with health and function measures were evaluated by chi-squared test and multivariate logistic regression analysis.

Results: We found that the prevalence of diabetes and pre-diabetes was 13.21% and 25.16%. The prevalence of diabetes increased with advanced age (12.37%, 15.98% and 16.52% among persons who were 45 to 55, 55 to 65 and ≥65 years old, respectively), educational background (14.52%, 15.52% and 15.58% among persons who were illiterate, had primary education and had secondary or above education) and weight (8.18%, 17.05% and 22.54% among persons with a body mass index of 18.5 to 24.9, 25.0 to 29.9 and ≥30.0, respectively). The prevalence of diabetes was higher among urban residents than among rural residents (19.04% vs. 12.85%). We also observed that aged between 55 and 65 years, obesity, history of hypertension and coronary heart disease, and inactivity were significant risk factors of awareness of diabetes.

Conclusion: Our results indicated that diabetes is high prevalent in adults aged 45 years or above in China. The potentially modifiable risk factors should be further studied to develop interventions and strategies aimed at prevention and treatment of diabetes among middle-aged and older Chinese adults.
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http://dx.doi.org/10.1002/edm2.265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8279593PMC
July 2021

Tumor targeting nanoparticle E7-HSP110-RGD elicits potent anti-tumor immune response in a CD8-dependent manner in cervical cancer-bearing mouse model.

Hum Vaccin Immunother 2021 Jul 16:1-10. Epub 2021 Jul 16.

Department of Dermatology, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.

Our previous research verified that HSP (heat shock protein) 110 could enhance the anti-tumor effect of HPV16 E7 epitope. In this study, to optimize the immunotherapy of this vaccine type, we developed and evaluated the anti-tumor immunity of a nanoparticle vaccine format assembling with E7-HSP110 fusion expression plasmid and RGD-GGG-K polypeptide. The nanoparticle vaccine was self-assembled from positively charged RGD-GGG-K polypeptide and negatively charged fusion expression plasmid pIRES2-3× E7-HSP110-EGFP. The particle size, stability, expression of E7-HSP110 fusion protein and the target ability of nanoparticle were determined, respectively. Specific CTL responses were determined by E7 tetramer staining and cytotoxicity assay in TC-1 tumor-bearing mice (CD4/CD8 knockout). The preventive and therapeutic experiments of nanoparticle vaccine were investigated in TC-1 tumor-bearing mice. Results showed that the RGD-GGG-K polypeptide and pIRES2-3× E7-HSP110-EGFP plasmid self-assembled nanoparticles about 100 nanometers in diameter when the charge ratios of peptide/plasmid were 2. The nanoparticles effectively entered TC-1 cells directed by RGD target-peptide, and correctly expressed the E7-HSP110 fusion protein. The HSP110 effectively facilitated nanoparticles activating CD8T cells than nanoparticles without HSP110, including the CD8 T cell number and the IFN-γ level; in contrast, the CD4T cells immune response remained indiscriminate among the mice groups. This nanoparticle formulation inhibited tumor growth and prolonged the survival duration in the prophylactic and therapeutic mouse models. Therefore, the RGD-based tumor-targeting nanoparticle expressing E7-HSP110 fusion protein can efficiently evoke anti-tumor activity and thus suggests it might be a favorable candidate for cervical cancer immunotherapy.
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http://dx.doi.org/10.1080/21645515.2021.1933875DOI Listing
July 2021

Interaction between testosterone and obesity on hypertension: A population-based cross-sectional study.

Atherosclerosis 2021 Jun 24;330:14-21. Epub 2021 Jun 24.

Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. Electronic address:

Background And Aims: We aimed to evaluate the effects of serum testosterone, obesity and their interaction on blood pressure (BP) parameters and hypertension among Chinese rural adults.

Methods: A total of 6199 adults were recruited from the Henan Rural Cohort Study. Serum testosterone was measured by liquid chromatography-tandem mass spectrometry. Logistic regression and linear regression were used to evaluate the association between testosterone, hypertension and BP parameters (including systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure (PP), and mean arterial pressure (MAP)). A generalized linear model was performed to identify the interactive effects of testosterone and obesity on hypertension.

Results: High levels of serum testosterone were associated with a lower prevalence of hypertension in males (odds ratio (OR): 0.69, 95% confidence interval (CI): 0.53, 0.89). After stratification by obesity, observed associations were only found in non-obese males. Each one-unit increase in ln-testosterone was associated with a 1.23 mmHg decrease in SBP, 0.97 mmHg decrease in DBP, and 1.05 mmHg decrease in MAP among males. Moreover, interactive effects between testosterone and obesity on hypertension and BP parameters were found, indicating that protective effects of serum testosterone on hypertension and BP parameters were counteracted and accompanied by increased values of obesity-related indicators in males, and additional testosterone increased BP parameters and prevalence of hypertension at high levels of waist-to-hip ratio and waist-to-height ratio in females.

Conclusions: Elevated levels of serum testosterone were associated with decreased BP parameters and prevalent hypertension in males, and obesity modifying effects of serum testosterone on BP parameters and hypertension.
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http://dx.doi.org/10.1016/j.atherosclerosis.2021.06.906DOI Listing
June 2021

Mind-Body Exercise Modulates Locus Coeruleus and Ventral Tegmental Area Functional Connectivity in Individuals With Mild Cognitive Impairment.

Front Aging Neurosci 2021 14;13:646807. Epub 2021 Jun 14.

Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States.

Mild cognitive impairment (MCI) is a common global health problem. Recently, the potential of mind-body intervention for MCI has drawn the interest of investigators. This study aims to comparatively explore the modulation effect of Baduanjin, a popular mind-body exercise, and physical exercise on the cognitive function, as well as the norepinephrine and dopamine systems using the resting state functional connectivity (rsFC) method in patients with MCI. 69 patients were randomized to the Baduanjin, brisk walking, or healthy education control group for 6 months. The Montreal Cognitive Assessment (MoCA) and magnetic resonance imaging (MRI) scans were applied at baseline and at the end of the experiment. Results showed that (1) compared to the brisk walking, the Baduanjin significantly increased MoCA scores; (2) Baduanjin significantly increased the right locus coeruleus (LC) and left ventral tegmental area (VTA) rsFC with the right insula and right amygdala compared to that of the control group; and the right anterior cingulate cortex (ACC) compared to that of the brisk walking group; (3) the increased right LC-right insula rsFC and right LC-right ACC rsFC were significantly associated with the corresponding MoCA score after 6-months of intervention; (4) both exercise groups experienced an increased effective connectivity from the right ACC to the left VTA compared to the control group; and (5) Baduanjin group experienced an increase in gray matter volume in the right ACC compared to the control group. Our results suggest that Baduanjin can significantly modulate intrinsic functional connectivity and the influence of the norepinephrine (LC) and dopamine (VTA) systems. These findings may shed light on the mechanisms of mind-body intervention and aid the development of new treatments for MCI.
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http://dx.doi.org/10.3389/fnagi.2021.646807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236862PMC
June 2021

Proteomics Analysis of the Spinal Dorsal Horn in Diabetic Painful Neuropathy Rats With Electroacupuncture Treatment.

Front Endocrinol (Lausanne) 2021 10;12:608183. Epub 2021 Jun 10.

College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China.

Background: Clinical evidence demonstrates that electro-acupuncture (EA) of the Zu sanli (ST36) and Shen shu (BL23) acupoints is effective in relieving diabetic painful neuropathy (DPN); however, the underlying molecular mechanism requires further investigation, including the protein molecules associated with EA's effects on DPN.

Methods: Sprague-Dawley adult male rats (n =36) were randomly assigned into control, DPN, and EA groups (n=12 each). After four weeks of EA treatment, response to mechanical pain and fasting blood glucose were analyzed. A tandem mass tag (TMT) labeling approach coupled with liquid chromatography with tandem mass spectrometry was used to identify potential biomarkers in the spinal dorsal horn. Further, proteomics analysis was used to quantify differentially expressed proteins (DEPs), and gene ontology, KEGG pathways, cluster, and string protein network interaction analyses conducted to explore the main protein targets of EA.

Results: Compared with the DPN model group, the mechanical pain threshold was significantly increased, while the fasting blood glucose levels were clearly decreased in EA group rats. Proteomics analysis was used to quantify 5393 proteins, and DEPs were chosen for further analyses, based on a threshold of 1.2-fold difference in expression level (P < 0.05) compared with control groups. Relative to the control group, 169 down-regulated and 474 up-regulated proteins were identified in the DPN group, while 107 and 328 proteins were up- and down-regulated in the EA treatment group compared with the DPN group. Bioinformatics analysis suggested that levels of proteins involved in oxidative stress injury regulation were dramatically altered during the EA effects on DPN.

Conclusions: Our results provide the valuable protein biomarkers, which facilitates unique mechanistic insights into the DPN pathogenesis and EA analgesic, antioxidant stress and hypoglycemic effect.
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http://dx.doi.org/10.3389/fendo.2021.608183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8224168PMC
June 2021

Coexistence and Coupling of Multiple Charge Orderings and Spin States in Hexagonal Ferrite.

Nano Lett 2021 Jul 25;21(13):5782-5787. Epub 2021 Jun 25.

Department of Condensed Matter Physics and Materials Science, Brookhaven National Laboratory, Upton, New York 11973, United States.

The coupling between charge and spin orderings in strongly correlated systems plays a crucial role in fundamental physics and device applications. As a candidate of multiferroic materials, LuFeO with a nominal Fe valence state has the potential for strong charge-spin interactions; however, these interactions have not been fully understood until now. Here, combining complementary characterization methods with theoretical calculations, two types of charge orderings with distinct magnetic properties are revealed. The ground states of LuFeO are decided by the parallel/antiparallel coupling of both charge and spin orderings in the adjacent FeO double layers. Whereas the ferroelectric charge ordering remains ferrimagnetic below 230 K, the antiferroelectric ordering undergoes antiferromagnetic-ferrimagnetic-paramagnetic transitions from 2 K to room temperature. This study demonstrates the unique aspects of strong spin-charge coupling within LuFeO. Our results shed light on the coexistence and competing nature of orderings in quantum materials.
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http://dx.doi.org/10.1021/acs.nanolett.1c01624DOI Listing
July 2021

Author Correction: Single-cell analysis of developing and azoospermia human testicles reveals central role of Sertoli cells.

Nat Commun 2021 Jun 18;12(1):3949. Epub 2021 Jun 18.

Department of Andrology, the Center for Men's Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.

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http://dx.doi.org/10.1038/s41467-021-24242-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213851PMC
June 2021

Association between maternal exposure to gaseous pollutants and atrial septal defect in China: A nationwide population-based study.

Environ Res 2021 Jun 9;200:111472. Epub 2021 Jun 9.

The Joint Laboratory for Pulmonary Development and Related Diseases, West China Institute of Women and Children's Health, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, 610041, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, 610041, China; National Center for Birth Defects Monitoring, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, 610041, China; Med-X Center for Informatics, Sichuan University, Chengdu, Sichuan, 610041, China. Electronic address:

Background: The association between maternal exposure to gaseous air pollutants and congenital heart defects (CHD) remains unclear. The concentration-response relationship and the time windows of susceptibility to gaseous pollutants may vary by pollutant species and CHD subtypes.

Objective: We aimed to examine the relationship between maternal exposures to four species of gaseous pollutants (NO, O, SO, and CO) and atrial septal defect (ASD), which is a common subtype of CHD, and to determine the critical time windows of susceptibility for each gaseous pollutant.

Methods: Among 1,253,633 infants born between October 1, 2013 and December 31, 2016 in China, 1937 newborns were diagnosed with isolated ASD, a prevalence of 1.55‰. Maternal exposures to the gaseous pollutants were estimated by matching the geocoded maternal addresses with the gridded ambient concentrations. The adjusted odds ratios (aOR) between exposures and ASD were quantified by using mixed-effects logistic regression models.

Results: We found significantly positive associations between ASD and maternal exposures to NO, O, SO, and CO during entire pregnancy, first-, second-, and third-trimester. However, no statistically significant association was found between maternal exposure to PM, PM and ASD risk (P > 0.05). In the fully adjusted model with respect to average exposure over entire pregnancy, the adjusted odds ratios (aOR) for each 10 μg/m increment of NO, O, SO were 1.33 (95% CI: 1.22-1.45), 1.13 (95% CI: 1.10-1.16), 1.28 (95% CI: 1.20-1.35), respectively; the aOR for each 100 μg/m increment of CO was 1.10 (95% CI: 1.06-1.15). The observed concentration-response relationships varied by exposure periods and pollutants, with the strongest association for NO during the 1st-8th embryology weeks, for O during the third trimester, for SO during the second trimester, and for CO without obvious variation.

Conclusions: The findings suggest an increased risk of ASD in association with maternal exposures to four common gaseous pollutants. From the perspective of birth defects prevention and ASD risk mitigation, it is critical to reduce maternal exposure to gaseous pollutants especially during the most susceptible time windows.
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http://dx.doi.org/10.1016/j.envres.2021.111472DOI Listing
June 2021

Co-expression Network Revealed Roles of RNA mA Methylation in Human β-Cell of Type 2 Diabetes Mellitus.

Front Cell Dev Biol 2021 18;9:651142. Epub 2021 May 18.

The Institute of Rehabilitation Industry, Fujian University of Traditional Chinese Medicine, Fuzhou, China.

RNA mA methylation plays an important role in the pathogenesis of type 2 diabetes mellitus (T2DM). RNA modifications and RNA-modifying regulators have recently emerged as critical factors involved in β-cell function and insulin resistance, including "writers," "erasers," and "readers." However, their key roles in regulating gene expression in T2DM remain unclear. The construction of co-expression network could provide a cue to resolve this complex regulatory pathway. We collected the transcriptome datasets of β-cell in diabetic patients, calculated the partial correlation coefficient, excluded the influence from control variables of diabetes related genes, and identified the genes significantly co-expressed with mA regulators. A total of 985 genes co-expressed with mA regulators (Co-mAR) were identified, which were enriched in metabolic process, MAPK and EGFR signaling pathways. Some of them have been confirmed to play a pivotal role in T2DM, including , , , , and , etc. Further, we analyzed the mA modification characteristics of Co-mAR in β-cell and identified 228 Co-mAR containing mA methylation sites, involving in several key signaling pathways regulating T2DM. We finally screened out 13 eQTL-SNPs localized in Co-mARs, and 4 have been reported strongly associated with diabetes, including , , , and . This co-expression analysis provides important information to reveal the potential regulatory mechanism of RNA mA methylation in T2DM.
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http://dx.doi.org/10.3389/fcell.2021.651142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168466PMC
May 2021

The Association Between Insulin Resistance, Leptin, and Resistin and Diabetic Nephropathy in Type 2 Diabetes Mellitus Patients with Different Body Mass Indexes.

Diabetes Metab Syndr Obes 2021 24;14:2357-2365. Epub 2021 May 24.

Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.

Aim: This study aimed to compare HOMA-IR, leptin, and resistin as the risk factors for diabetic nephropathy in the type 2 diabetes mellitus (T2DM) patients with different BMI classifications.

Materials And Methods: A total of 309 patients with T2DM were enrolled in this cross-sectional study. All participants were divided into three groups according to BMI: the normal weight group (18.5 kg/m≤BMI<24 kg/m), the overweight group (24kg/m≤BMI<28 kg/m) and the obesity group (BMI≥28 kg/m). The clinical information and laboratory examinations were recorded in detail. Leptin and resistin levels were measured using enzyme-linked immunosorbent assay (ELISA).

Results: Higher HOMA-IR, leptin and resistin levels were found to be the risk factors for diabetic nephropathy when we made comparisons in the total population (<0.05). In the normal weight group, logistic regression analysis showed that T2DM patients with higher HOMA-IR (OR=4.210, =0.001), leptin (OR=2.474, =0.031) and resistin levels (OR=8.299, <0.001) had nearly 4-fold, 2-fold and 8-fold risk for diabetic nephropathy, respectively, after adjustments. The receiver operating characteristic (ROC) curves indicated that the area under the curves (AUCs) of HOMA-IR and resistin were 0.699 (95% CI 0.617-0.772) and 0.790 (95% CI 0.715-0.854), respectively, which were significantly larger than the AUC of 0.5 (all <0.001). However, no significant association was observed between HOMA-IR, leptin, and resistin and renal complications (all >0.05) in the overweight and obesity groups in both logistic regression and AUC analysis.

Conclusion: Higher insulin resistance, leptin and resistin levels were observed as risk factors for diabetic nephropathy in T2DM patients with lower BMI. These were not obvious in the overweight and obese patients.
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http://dx.doi.org/10.2147/DMSO.S305054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163637PMC
May 2021

Lycopene Attenuates Hypoxia-Induced Testicular Injury by Inhibiting PROK2 Expression and Activating PI3K/AKT/mTOR Pathway in a Varicocele Adult Rat.

Evid Based Complement Alternat Med 2021 8;2021:3471356. Epub 2021 May 8.

Department of Urology, Shandong Provincial Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250014, Shandong, China.

Purpose: The aim of this study was to evaluate the effect of lycopene on hypoxia-induced testicular injury in rat model and explore the underlying mechanism.

Methods: Six-week-old male Wistar rats ( = 36) were randomly divided into three groups ( = 12/group): a normal group (NG, sham control), a varicocele group (VG), and a varicocele treated by lycopene group (VLG). Bilateral renal veins constriction was performed on rats in VG and VLG. Simultaneously, rats in VLG were treated to lycopene by intragastric administration. Four weeks later, sperm was collected for sperm analysis. Testes and epididymides were harvested for morphological change analysis, histologic analysis, ELISA, qRT-PCR, and western blot.

Results: Our observations were that lycopene improved the hypoxia-induced testicular injury in vivo. Prokineticin 2(PROK2) and prokineticin receptor 2 (PROKR2) were overexpressed in VG ( < 0.01), and lycopene inhibited the PROK2 expression ( < 0.01). Proliferating cell nuclear antigen (PCNA) and sex hormones were increased by lycopene in VLG ( < 0.05). Lycopene restored the quality and activity of sperm by blocking PROK2 expression ( < 0.05). The expression of VEGF was increased, as HIF-1/NF-B pathway was upregulated in VLG ( < 0.05). Meanwhile, expression of pAKT/AKT in VLG was higher than that in VG ( < 0.05). In addition, lycopene reduced levels of interleukin-1 (IL-1) and interleukin-2 (IL-2) in VLG ( < 0.05), compared to NG.

Conclusions: Lycopene improved the hypoxia-induced testicular injury by inhibiting the expression of PROK2 and decreasing levels of IL-1 and IL-2, which might show us a novel and promising treatment for varicocele testicular injury.
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http://dx.doi.org/10.1155/2021/3471356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149244PMC
May 2021

STEP® vectors for rapid generation of stable transfected CHO cell pools and clones with high expression levels and product quality homogeneity of difficult-to-express proteins.

Protein Expr Purif 2021 Oct 25;186:105920. Epub 2021 May 25.

Batavia Biosciences Inc., 300 Trade Center Suite 6650, Woburn, MA, USA. Electronic address:

Many proteins produced in CHO cells need evaluation for their clinical and commercial potential. Traditional methods based on stable clone generation are slow and unsuitable for screening larger numbers of proteins, while transient expression technologies are fast but unpredictable regarding product quality and lacking an optional path to subcloning. The STEP® vector technology introduced here combines the best properties of both methods. STEP® vectors contain a strong transcriptional cassette driving expression of a bicistronic mRNA. The gene-of-interest (GOI) is cloned upstream of a functionally impaired zeocin resistance gene (FI-Zeo) whose translation is coupled to that of the GOI through an IRES. Stable transfected cells surviving zeocin selection produce high levels of FI-Zeo and thus, high levels of the GOI-encoded protein. By using different spacers, the translational coupling efficiency and selection strength can be controlled allowing maximization of expression of any GOI. Production of laronidase and factor VII (FVII) is presented as examples of unrelated, difficult-to-express (DTE) proteins. First step is rapid generation of transfected pools with the STEP® vectors. All high expressing surviving pools showed high product quality homogeneity as did monoclonal cell lines obtained from the top pools. Up to 500 μg/mL laronidase was obtained with virtually identical glycosylation profile as reference product. For FVII, cell specific productivity of 0.45 pg/cell/day with 50 IU/μg protein matched highest reported levels of reference product even before process development. Taken together, STEP® vector technology is ideally suited for rapid, small to large-scale production of DTE proteins compared to traditional methods.
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http://dx.doi.org/10.1016/j.pep.2021.105920DOI Listing
October 2021

Two-dimensional ZrC as a novel anode material with high capacity for sodium ion battery.

Phys Chem Chem Phys 2021 Jun 26;23(22):12731-12738. Epub 2021 May 26.

College of Physics, Guizhou University, Guiyang 550025, People's Republic of China.

Rational design of high-performance anode materials is of paramount importance for developing rechargeable lithium ion batteries (LIBs) and sodium ion batteries (SIBs). In this work, a ZrC monolayer is predicted by performing the particle swarm optimization (PSO) algorithm. The high energetic, dynamic, and thermal stabilities of the ZrC monolayer are confirmed by cohesive energy, phonon dispersion, and molecular dynamics simulations, respectively. Unexpectedly, we find that the theoretical specific capacity for Na on the ZrC monolayer reaches as high as 932 mA h g, which is even higher than that of Li. Meanwhile, the diffusion energy barrier of Na on the ZrC monolayer is only 0.02 eV, ensuring the ultrafast charge/discharge rate. Additionally, the calculated open-circuit voltage (OCV) suggests that the change of Na intercalation voltage is steady. Therefore, our results consistently demonstrate that the ZrC monolayer can be an ideal anode material for SIBs.
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http://dx.doi.org/10.1039/d1cp00050kDOI Listing
June 2021

The Effects of Exercise Interventions on Balance Capacity in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.

Inquiry 2021 Jan-Dec;58:469580211018284

College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China.

The effect of exercise intervention on balance capacity among type 2 diabetes mellitus (T2DM) patients has not been evaluated. The objective of this systematic review and meta-analysis is to investigate the effect of exercise intervention on balance capacity among T2DM patients compared to the control group (usual care, waitlist, no-treatment, education). We conducted a comprehensive literature search through PubMed, EMBASE, Physiotherapy Evidence Database (PEDro), Cochrane library, Web of Science (WOS) from inception to August 2020. The literature language was limited to English. Randomized controlled trials (RCTs) or quasi-experimental (Q-E) trials that examined the effect of exercise intervention on balance capacity among T2DM patients were included. We used the standard methods of meta-analysis to evaluate the outcomes of exercise intervention for balance capacity of T2DM patients. A total of 14 trials (11 RCTs and 3 Q-E trials) involving 883 participants were eligible. The meta-analysis of some studies demonstrated that exercise intervention could significantly improve Berg Balance Scale (BBS) (MD = 2.56; 95%CI [0.35, 4.77];  = .02), SLST (Single Leg Stance Test) under the eyes-open (EO) condition (MD = 3.63; 95%CI [1.79, 5.47];  = .0001) and eyes-close (EC) condition (MD = 0.41; 95%CI [0.10, 0.72];  = .01) compared to control group. There was no significant difference in Time Up and Go Test (TUGT) (MD = -0.75; 95%CI [-1.69, 0.19];  = .12) and fall efficacy (SMD = -0.44; 95%CI [-0.86, -0.01];  = .05). Narrative review of some studies indicated that exercise intervention could improve postural stability measured by Sensory Organization Test (SOT) and Center of Pressure (COP) variables, etc. This systematic review and meta-analysis summarized that exercise intervention could improve balance capacity in T2DM patients. However, further studies with high quality are required to evaluate its effect.
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http://dx.doi.org/10.1177/00469580211018284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155768PMC
May 2021

Advances of circular RNAs in thyroid cancer: An overview.

Biomed Pharmacother 2021 Aug 15;140:111706. Epub 2021 May 15.

Department of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Division of Hand, Plastic and Aesthetic Surgery, University Hospital, LMU Munich, Pettenkoferstraße 8a, 80336, Munich, Germany. Electronic address:

Circular RNA (circRNA) is a general term for a type of single-stranded RNAs, they are primarily generated via exon back-splice process in precursor mRNAs (pre-mRNAs). circRNAs refer to an emerging type of endogeneity-correlated closed molecules of RNA in a covalent manner. They mainly function as microRNA sponges, protein brackets, and regulatory element in transcription and splicing process. Recently, it has also starting been noticed that they serve as extraordinary models involved in polypeptides producing process. Although circRNAs have been extensively studied, their function in thyroid carcinoma is still lacking. Thus, we present the latest advances in circRNA research and summarize their fundamental rules of regulating process as well as the mechanism. More importantly, We mainly review the role and mechanism of circRNA in thyroid cancer, which provides an emerging perspective and theoretically supports the treatment of thyroid cancer.
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http://dx.doi.org/10.1016/j.biopha.2021.111706DOI Listing
August 2021

Laser-Scanning-Guided Assembly of Quasi-3D Patterned Arrays of Plasmonic Dimers for Information Encryption.

Adv Mater 2021 Jun 10;33(24):e2100325. Epub 2021 May 10.

State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai, 200438, China.

The application of plasmonic dimeric nanostructures in color displays, data storage, and especially metamaterials necessitates the patterning of dimers into ordered arrays, but controllable assembly of plasmonic nanoparticles into patterned dimer arrays on substrates still remains a challenge. Here, a facile laser-scanning-based strategy to fabricate quasi-3D patterned arrays of plasmonic nanoparticle dimers with controlled orientation for plasmonic information encryption is reported. Laser scanning of polymer-covered plasmonic nanoparticle (e.g., gold) arrays selectively exposes the surface of irradiated nanoparticle via localized photothermal heating, guiding the assembly of another type of nanoparticles onto the exposure nanoparticle surface to form dimers on substrates. This combined top-down/bottom-up approach is highly flexible in forming high-resolution patterns of plasmonic dimers from nanoparticles of different sizes and shapes. The z-axis orientation, interparticle spacing, and nanoparticle size and shape of plasmonic dimers can be precisely tuned, enabling the modulation of the coupled resonances of the dimer arrays. Moreover, it is demonstrated that the patterned dimer arrays can be used in information encryption where their plasmonic color can be repeatedly displayed and erased. This work provides an important addition to tools for the fabrication of patterned complex plasmonic nanostructures from as-synthesized nanoparticles with broad applications.
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http://dx.doi.org/10.1002/adma.202100325DOI Listing
June 2021

Long-term exposure to particulate matter and residential greenness in relation to androgen and progesterone levels among rural Chinese adults.

Environ Int 2021 08 4;153:106483. Epub 2021 May 4.

Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. Electronic address:

Background: Population-based studies on the associations of long-term exposure to particulate matter (PM) with androgen and progesterone are still scant. Residential greenness is benefits health by promoting physical activity, reducing air pollution, and improving mental health, but it remains unclear whether it is related to androgen and progesterone levels among humans.

Aims: This study aimed to explore the individual and interactive effects of PM and residential greenness on serum testosterone and progesterone levels among rural Chinese adults.

Methods: A total of 6017 subjects were recruited from the baseline of the Henan Rural Cohort Study in 2016. Serum testosterone and progesterone were measured with liquid chromatography-tandem mass spectrometry. Particulate matters (PM) (PM, PM, and PM) were assessed by machine learning algorithms. Residential greenness was assessed using the normalized difference vegetation index (NDVI) within 500-m, 1000-m, and 3000-m buffers around participants' residences. The effects of air pollutants and residential greenness and their interaction on serum testosterone and progesterone levels were assessed using linear mixed-effects models with township as a random intercept.

Results: After adjusting for potential confounding factors, a 1 μg/m increase in PM or PM was associated with a 0.037 or 0.030 ng/ml increase in serum testosterone, respectively, in females and with a 0.111 or 0.182 ng/ml decrease in serum progesterone, respectively, in males. A 1 μg/m increase in PM, PM or PM was associated with a 0.222, 0.306, or 0.295 ng/ml decrease in serum progesterone, respectively, among females. Moreover, a 0.1-unit increase in NDVI was associated with a 0.310 ng/ml increase in serum testosterone and a 0.170 ng/ml increased in serum progesterone in males, as well as with a 0.143 ng/ml increase in serum progesterone in females. Interaction effects of PM and residential greenness on serum testosterone and progesterone levels were observed, indicating that the effects of residential greenness on serum testosterone and progesterone were modified by high levels of PM. In addition, physical activity significantly mediated 2.92% of the estimated association between greenness and testosterone levels.

Conclusions: Our study suggested that long-term exposure to PM was positively associated with serum testosterone in males but negatively associated with progesterone levels in both genderssin. In addition, positive associations of residential greenness with serum testosterone and progesterone levels were observed, but they were modified by high levels of PM. Furthermore, the estimated effects of residential greenness on testosterone levels were partly mediated by physical activity.
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http://dx.doi.org/10.1016/j.envint.2021.106483DOI Listing
August 2021

Expression analysis of genes related to cold tolerance in .

PeerJ 2021 9;9:e10864. Epub 2021 Mar 9.

Key Laboratory of Beijing for the Control of Forest Pests, Beijing Forestry University, Beijing, China.

Pine beetles are well known in North America for their widespread devastation of pine forests. However, LeConte is an important invasive forest pest in China also. Adults and larvae of this bark beetle mainly winter at the trunks and roots of and ; larvae, in particular, result in pine weakness or even death. Since the species was introduced from the United States to Shanxi in 1998, its distribution has spread northward. In 2017, it invaded a large area at the junction of Liaoning, Inner Mongolia and Hebei provinces, showing strong cold tolerance. To identify genes relevant to cold tolerance and the process of overwintering, we sequenced the transcriptomes of wintering and non-wintering adult and larval using the Illumina HiSeq platform. Differential expression analysis methods for other non-model organisms were used to compare transcript abundances in adults and larvae at two time periods, followed by the identification of functions and metabolic pathways related to genes associated with cold tolerance. We detected 4,387 and 6,091 differentially expressed genes (DEGs) between sampling dates in larvae and adults, respectively, and 1,140 common DEGs, including genes encoding protein phosphatase, very long-chain fatty acids protein, cytochrome P450, and putative leucine-rich repeat-containing proteins. In a Gene Ontology (GO) enrichment analysis, 1,140 genes were assigned to 44 terms, with significant enrichment for cellulase activity, hydrolase activity, and carbohydrate metabolism. Kyoto Encyclopedia of Genes and Genomes (KEGG) classification and enrichment analyses showed that the lysosomal and purine metabolism pathways involved the most DEGs, the highly enriched terms included autophagy-animal, pentose and glucuronate interconversions and lysosomal processes. We identified 140 candidate genes associated with cold tolerance, including genes with established roles in this trait (e.g., genes encoding trehalose transporter, fructose-1,6-bisphosphatase, and trehalase). Our comparative transcriptome analysis of adult and larval in different conditions provides basic data for the discovery of key genes and molecular mechanisms underlying cold tolerance.
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http://dx.doi.org/10.7717/peerj.10864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7953874PMC
March 2021

Genetic polymorphism of IDOL gene was associated with the susceptibility of coronary artery disease in Han population in Xinjiang, China.

Hereditas 2021 Apr 12;158(1):12. Epub 2021 Apr 12.

Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, P.R. China.

Background: Coronary artery disease (CAD) is the leading cause of death worldwide. In this study, we aimed to explore whether some genetic variants of the human IDOL gene were associated with CAD among Chinese population in Xinjiang.

Methods: We designed two independent case-control studies. The first one included in the Han population (448 CAD patients and 343 controls), and the second one is the Uygur population (304 CAD patients and 318 controls). We genotyped three SNPs (rs2072783, rs2205796, and rs909562) of the IDOL gene.

Results: Our results revealed that, in the Han female subjects, for rs2205796, the distribution of alleles, dominant model (TT vs. GG + GT) and the additive model (GG + TT vs. GT) showed significant differences between CAD patients and the control subjects (P = 0.048, P = 0.014, and P = 0.032, respectively).

Conclusions: The rs2205796 polymorphism of the IDOL gene is associated with CAD in the Chinese Han female population in Xinjiang, China.
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http://dx.doi.org/10.1186/s41065-021-00178-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042894PMC
April 2021

Block-Random Copolymer-Micellization-Mediated Formation of Polymeric Patches on Gold Nanoparticles.

J Am Chem Soc 2021 Apr 26;143(13):5060-5070. Epub 2021 Mar 26.

State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200438, People's Republic of China.

Patchy colloidal nanoparticles are important for a broad range of applications, especially as building blocks for complex and functional structural materials, but the controllable generation of chemical patches on as-synthesized nanoparticles remains a challenge. This article describes a robust strategy for the scalable synthesis of high-quality patchy nanoparticles in high yield and solid content. A simple thermal treatment of a mixture of gold nanoparticles and thiol-terminated block-random copolymers in selected solvents produced a variety of patchy nanoparticles with a controlled morphology and number of polymeric patches (e.g., beanlike patch, one patch, two patches, three patches, multiple patches, and open-configuration patch). We show in experiments and simulations that the dynamic detachment/attachment of copolymers and the exchange of copolymers between the nanoparticle surface and free micelles in the solution-which are dictated by the architecture of copolymers-govern the formation of polymeric patches. This work not only offers an effective approach to patchy nanoparticles but also provides new insights into the phase behaviors of copolymers on nanoscale surfaces.
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http://dx.doi.org/10.1021/jacs.1c00310DOI Listing
April 2021

[Analysis of Changes and Factors Influencing Air Pollutants in the Beijing-Tianjin-Hebei Region During the COVID-19 Pandemic].

Huan Jing Ke Xue 2021 Mar;42(3):1205-1214

College of Resource Environment and Tourism, Capital Normal University, Beijing 100048, China.

A series of strict control measures were imposed in the Beijing-Tianjin-Hebei region in early 2020 to control the spread of COVID-19. These measures have led to a reduction of anthropogenic air pollutants, providing an opportunity to observe the contribution of human activities to local air pollution. In this study, the control period was divided into four stages:the before, early, middle, and later stages. Based on a variety of data including meteorological, traffic, and industrial manufacturing datasets, statistical methods were combined with spatial analysis to evaluate changes in air pollution and associated human impacts during each stage. In addition, suggestions are made for further regional air pollution control in the Beijing-Tianjin-Hebei area. Key results are as follows:① Overall, the AQI and the concentrations of six air pollutants, especially SO, PM, and NO, were lower during control period than during the equivalent period in 2019 (reductions of 26.5%, 24.3%, and 16.9%, respectively). From the before to later stages, pollutants (except O) showed a downward trend while O increased significantly during the before stage (by 76.2%) and the growth rate slowed during the middle and later stages; ②During the prior stage, Beijing experienced two periods with heavy air pollution days as a result of the local accumulation of pollutants, secondary transformation, and regional transport. The concentration of PM in February was nearly 60% lower than in February 2014 under similar meteorological conditions in Beijing; ③ Following an increase in traffic volume and industrial activity, changes in air pollutants tended to be stable or slightly increase during the middle and later stages of the control period. The grey relation coefficients between thermal radiation intensity anomalies and the main pollutants in heavy industrial cities were greater than 0.6, which means that the control of industrial emissions remains key to controlling air pollution.
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http://dx.doi.org/10.13227/j.hjkx.202007249DOI Listing
March 2021

Long-term exposure to PM and PM is associated with serum cortisone level and meat intake plays a moderation role.

Ecotoxicol Environ Saf 2021 Jun 16;215:112133. Epub 2021 Mar 16.

Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. Electronic address:

Background: Although short-term exposure to particulate matter (PM) was associated with increased glucocorticoids (GCs) levels, available evidence on associations of long-term exposure to PM and GCs levels is still scant. Previous studies has showed that meat intake is associated with sex hormones levels, but it is unknown whether meat intake is associated with GCs levels. Furthermore, the role of meat intake in the associations between PM and GCs levels remains unclear.

Aims: The aims of this study were to explore the associations of long-term exposure to PM and GCs levels among Chinese rural adults, and the role of meat intake in these associations.

Materials And Methods: A total of 6223 subjects were recruited from the Henan Rural Cohort Study. Serum GCs levels were measured with liquid chromatography-tandem mass spectrometry. The concentrations of PM (PM and PM) for each subject were assessed with machine learning algorithms. The food frequency questionnaire (FFQ) was used to obtain each participant' information on meat intake. The effects of PM and meat intake on GCs levels were assessed using generalized linear models. In addition, modification analyses were performed to identify the role of meat intake played in the associations of PM with serum GCs levels.

Results: Per 1 μg/m increment in PM or PM concentration was associated with a 0.364 ng/ml (95% confidence interval (CI): 0.234, 0.494) or 0.227 ng/ml (95%CI: 0.110, 0.343) increase in serum cortisone, respectively. In addition, the moderation effects of total meat intake and red meat intake on the associations of long-term exposure to PM or PM with serum cortisone were observed (P < 0.05), indicating that individuals who had high levels of PM or PM and meat intake were more susceptible to have a higher state of serum cortisone.

Conclusions: Our findings suggested that long-term exposure to PM or PM was associated with serum cortisone. Moreover, meat intake was found to be a significant moderator in the association of PM or PM with serum cortisone levels.
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http://dx.doi.org/10.1016/j.ecoenv.2021.112133DOI Listing
June 2021

microRNA-21-5p from M2 macrophage-derived extracellular vesicles promotes the differentiation and activity of pancreatic cancer stem cells by mediating KLF3.

Cell Biol Toxicol 2021 Mar 17. Epub 2021 Mar 17.

Department of Pancreatic Surgery, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan, 430060, Hubei, China.

Aim: Given the fact that tumor-associated macrophage-derived extracellular vesicles (EVs) are attributable to tumor aggressiveness, this research intends to decode the mechanism of M2 macrophage-derived EVs in the differentiation and activities of pancreatic cancer (PaCa) stem cells via delivering microRNA (miR)-21-5p.

Methods: Polarized M2 macrophages were induced, from which EVs were collected and identified. miR-21-5p expression in M2 macrophage-derived EVs was tested. After cell sorting, CD24CD44EpCAM stem cells were co-cultured with M2 macrophages, in which miR-21-5p was upregulated or downregulated. The effects of M2 macrophage-derived EVs and miR-21-5p on Nanog/octamer-binding transcription factor 4 (Oct4) expression, sphere formation, colony formation, invasion and migration capacities, apoptosis, and in vivo tumorigenic ability were examined. Krüppel-like factor 3 (KLF3) expression and its interaction with miR-21-5p were determined.

Results: M2 macrophage-derived EVs promoted PaCa stem cell differentiation and activities. miR-21a-5p was upregulated in M2 macrophage-derived EVs. miR-21a-5p downregulation in M2 macrophage-derived EVs inhibited Nanog/Oct4 expression and impaired sphere-forming, colony-forming, invasion, migration, and anti-apoptosis abilities of PaCa stem cells in vitro and tumorigenic ability in vivo. miR-21-5p targeted KLF3 to mediate the differentiation and activities of PaCa stem cells, and KLF3 was downregulated in PaCa stem cells.

Conclusion: This work explains that M2 macrophage-derived exosomal miR-21a-5p stimulates differentiation and activity of PaCa stem cells via targeting KLF3, paving a novel way for attenuating PaCa stemness.
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http://dx.doi.org/10.1007/s10565-021-09597-xDOI Listing
March 2021

Comparative transcriptome analysis of the newly discovered insect vector of the pine wood nematode in China, revealing putative genes related to host plant adaptation.

BMC Genomics 2021 Mar 16;22(1):189. Epub 2021 Mar 16.

Key Laboratory of Beijing for the Control of Forest Pests, Beijing Forestry University, Beijing, China.

Background: In many insect species, the larvae/nymphs are unable to disperse far from the oviposition site selected by adults. The Sakhalin pine sawyer Monochamus saltuarius (Gebler) is the newly discovered insect vector of the pine wood nematode (Bursaphelenchus xylophilus) in China. Adult M. saltuarius prefers to oviposit on the host plant Pinus koraiensis, rather than P. tabuliformis. However, the genetic basis of adaptation of the larvae of M. saltuarius with weaken dispersal ability to host environments selected by the adult is not well understood.

Results: In this study, the free amino and fatty acid composition and content of the host plants of M. saltuarius larvae, i.e., P. koraiensis and P. tabuliformis were investigated. Compared with P. koraiensis, P. tabuliformis had a substantially higher content of various free amino acids, while the opposite trend was detected for fatty acid content. The transcriptional profiles of larval populations feeding on P. koraiensis and P. tabuliformis were compared using PacBio Sequel II sequencing combined with Illumina sequencing. The results showed that genes relating to digestion, fatty acid synthesis, detoxification, oxidation-reduction, and stress response, as well as nutrients and energy sensing ability, were differentially expressed, possibly reflecting adaptive changes of M. saltuarius in response to different host diets. Additionally, genes coding for cuticle structure were differentially expressed, indicating that cuticle may be a potential target for plant defense. Differential regulation of genes related to the antibacterial and immune response were also observed, suggesting that larvae of M. saltuarius may have evolved adaptations to cope with bacterial challenges in their host environments.

Conclusions: The present study provides comprehensive transcriptome resource of M. saltuarius relating to host plant adaptation. Results from this study help to illustrate the fundamental relationship between transcriptional plasticity and adaptation mechanisms of insect herbivores to host plants.
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http://dx.doi.org/10.1186/s12864-021-07498-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7968331PMC
March 2021

Effects of physical activity on cognitive function among patients with diabetes in China: a nationally longitudinal study.

BMC Public Health 2021 03 11;21(1):481. Epub 2021 Mar 11.

Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, 100191, China.

Background: We aimed to examine the effect of physical activity on different cognitive domains among patients with diabetes.

Methods: We used two waves of data from the Chinese Health and Retirement Longitudinal Study (CHARLS, 2013-2015), a nationally representative dataset of Chinese population aged over 45. Total physical activity scores were calculated based on the International Physical Activity Questionnaire (IPAQ). Executive function and episodic memory were used as measures of cognitive function. We conducted lagged dependent variable models to explore the association between physical activity and cognitive function in full sample as well as two different age groups (45-65, ≥65).

Results: 862 diabetic patients were included. We found that diabetic participants who had greater level of physical activity at baseline were associated with better episodic memory function in 2 years (p < 0.05). Moreover, physical activity was significantly associated with less decline in episodic memory in fully adjusted models, and the associations were stronger among patients aged 45-65 years (p < 0.05). No statistically significant association was found between physical activity and executive function in all age groups.

Conclusions: Physical activity may prevent some of the potential decline in episodic memory in diabetic patients. Clinicians and public health departments should strengthen the promotion of physical activity and develop early screening tools among diabetic participants to prevent the progression of cognitive impairment.
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http://dx.doi.org/10.1186/s12889-021-10537-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948339PMC
March 2021

Retraction Note to: Circ-TFCP2L1 Promotes the Proliferation and Migration of Triple Negative Breast Cancer through Sponging miR-7 by Inhibiting PAK1.

J Mammary Gland Biol Neoplasia 2021 Mar;26(1):87

Department of General Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.

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http://dx.doi.org/10.1007/s10911-021-09481-8DOI Listing
March 2021

Simultaneous fluorescence determination of bisphenol A and its halogenated analogs based on a molecularly imprinted paper-based analytical device and a segment detection strategy.

Biosens Bioelectron 2021 May 20;180:113106. Epub 2021 Feb 20.

State Key Laboratory of Environment Health (Incubation), Key Laboratory of Environment and Health, Ministry of Education, Key Laboratory of Environment and Health (Wuhan), Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, #13 Hangkong Road, Wuhan, Hubei, 430030, China. Electronic address:

Bisphenol A (BPA) and its halogenated analogs tetrabromobisphenol A (TBBPA) and tetrachlorobisphenol A (TCBPA) are common environmental contaminants and a method for their simultaneous determination is urgently needed. A paper-based analytical device (PAD) was prepared using a metal-organic framework of UiO-66-NH coated with molecularly imprinted polymers (MIPs) using TBBPA as a template. The maximum adsorption capacity was 120.94 mg g and the imprinting factor was 4.07. The selective recognition ability of this PAD enabled the effective separation of TBBPA, TCBPA and BPA based on paper chromatography. Subsequently, the PAD cut into segments were used individually to determine the presence of target chemicals using a highly sensitive fluorescent method. Under ultraviolet light irradiation, UiO-66-NH acts as a photocatalyst to produce reactive oxygen species (ROS) that degrade TBBPA, TCBPA or BPA in the imprinted cavities and the fluorescent signal of 2',7'-dichlorodihydrofluorescein diacetate (HDCFDA) added as a ROS probe enabled the indirect determination of target chemicals. This method could determine BPA and its halogenated analogs in dust samples simultaneously with detection limits ranging from 0.14 to 0.30 ng g. The intraday relative standard deviation (RSD) was ≤6.8% and interday RSD was ≤8.1%. The recoveries ranged from 91.0 to 105.6% with RSD values that were ≤7.5%. The results stemmed from this method were consistent with those obtained from LC-MS/MS. It is an environmentally-friendly approach due to the degradation of target pollutants and possesses many advantages such as high selectivity, low cost and easy-to-fabrication.
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http://dx.doi.org/10.1016/j.bios.2021.113106DOI Listing
May 2021

Solute-adsorption enhanced heterogeneous nucleation: the effect of Cu adsorption on α-Al nucleation at the sapphire substrate.

Phys Chem Chem Phys 2021 Mar;23(9):5270-5282

School of Engineering, University of Leicester, Leicester, LE1 7RH, UK.

Interfacial adsorption of solute atoms is a promising means to tune heterogeneous nucleation. In this study, a new method has been established to theoretically evaluate the effect of solute addition on the nucleation potency of heterogeneous nucleation interfaces. The evaluation consists of three steps: (1) analyzing the solute adsorption behavior; (2) determining the nucleation mode; and (3) evaluating the effect of solute adsorption on nucleation potency using the solute-adsorbed interface model. A combination of the ab initio and molecular dynamics methods together with the two-phase thermodynamic model was used to evaluate a prototype Al-Cu/(0001) sapphire interface. It is found that solute Cu atoms adsorb at the interface between the melt and (0001) sapphire interface. The adsorption is driven by the strengthening of the Cu-Al bonds as revealed by the Bader charge analysis which is demonstrated to reduce interfacial energy. Furthermore, it is revealed that the interfacial adoption of Cu results in the formation of an Al-Cu adsorption layer, which enhances the interfacial chemical affinity thus enlarging the nucleation driving force. Meanwhile, the lattice mismatch between the sapphire substrate and the primary Al (α-Al) nucleus is decreased by Cu addition, which lowers the barrier for nucleation. The above two effects together increase the nucleation potency of the studied interface, which is in good agreement with previous experiments. It is proposed that the effect of solute adsorption shall be considered in the search for effective substrates for tuning the nucleation.
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http://dx.doi.org/10.1039/d0cp06000cDOI Listing
March 2021