Publications by authors named "Tao Hong"

669 Publications

Detection of EGFR Mutations in Cerebrospinal Fluid of EGFR-Mutant Lung Adenocarcinoma With Brain Metastases.

Front Oncol 2021 22;11:622142. Epub 2021 Mar 22.

Department of Medical Oncology, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China.

Background: We aimed to investigate the feasibility of detecting epidermal growth factor receptor (EGFR) mutations in cell-free DNA (cfDNA) from cerebrospinal fluid (CSF) and plasma of advanced lung adenocarcinoma (LADC) with brain metastases (BMs) by droplet digital polymerase chain reaction (ddPCR).

Methods: Thirty advanced LADC patients with BMs were enrolled, and their matched CSF and plasma samples were collected. Droplet digital PCR was used to test cfDNA in CSF and plasma for EGFR mutation status. The clinical response and prognosis were evaluated.

Results: Out of 30 patients, there were 21 females and 9 males, aged 34-75 years. In all of the cases, CSF cytology were negative. In ddPCR assays, 10 patients (33.3%) had EGFR mutation in CSF, including 3 cases of EGFR T790M mutation, and 16 patients (53.3%) had EGFR mutation in plasma, including 6 cases of EGFR T790M mutation. Five patients with activating EGFR mutations in CSF achieved an intracranial partial response (iPR) after combination treatment with the first-generation EGFR-tyrosine kinase inhibitors. Three patients with EGFR T790M mutations in CSF achieved iPR after second-line osimertinib treatment. The median overall survival and intracranial progression-free survival were 17.0 months and 11.0 months, respectively.

Conclusion: It was feasible to test EGFR mutation in cerebrospinal fluid and plasma. In LADC patients with brain metastasis, cerebrospinal fluid can be used as a liquid biopsy specimen to guide treatment strategy by monitoring EGFR mutation status.
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http://dx.doi.org/10.3389/fonc.2021.622142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8019917PMC
March 2021

Interplay Between the Intestinal Microbiota and Acute Graft-Versus-Host Disease: Experimental Evidence and Clinical Significance.

Front Immunol 2021 16;12:644982. Epub 2021 Mar 16.

Medical Center of Hematology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, China.

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative therapy for many hematological disorders and autoimmune diseases, but acute graft-versus-host disease (aGVHD) has remained a major obstacle that limits allo-HSCT and exhibits a daunting mortality rate. The gastrointestinal system is among the most common sites affected by aGVHD. Experimental advances in the field of intestinal microbiota research enhanced our understanding - not only of the quantity and diversity of intestinal microbiota - but also their association with homeostasis of the immune system and disease pathogenesis, including that of aGVHD. Meanwhile, ever-growing clinical evidence suggest that the intestinal microbiota is dysregulated in patients who develop aGVHD and that the imbalance may affect clinical outcomes, indicating a potential predictive role for microbiota dysregulation in aGVHD severity and prognosis. The current animal and human studies investigating the intestinal microbiota in aGVHD and the understanding of the influence and management of the microbiota in the clinic are reviewed herein. Taken together, monitoring and remodeling the intestinal microecology following allo-HSCT may provide us with promising avenues for diagnosing, preventing or treating aGVHD in the clinic.
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http://dx.doi.org/10.3389/fimmu.2021.644982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8010685PMC
March 2021

The effect of a performing arts intervention on caregivers of people with mild to moderately severe dementia.

Aging Ment Health 2021 Mar 26:1-10. Epub 2021 Mar 26.

AdventHealth Research Institute, Orlando, FL, USA.

Objectives: This study aimed to determine the feasibility and acceptability of a multi-modal performing arts intervention (MPAI) for caregivers of people with mild to moderately severe dementia. The secondary objective was to examine how MPAI might change caregiver burden, caregiver resiliency, and perceived quality of life (QoL) for care recipients.

Method: The study features a mixed-methods design. Caregivers ( = 32) completed the Zarit Burden Interview (caregiver burden) Brief Resilience Scale (resiliency) and Quality of Life-Alzheimer's disease measure (care recipient QoL) at five study timepoints. Semi-structured interviews ( = 15) documented the intervention's acceptability and caregivers' subjective experiences. Feasibility was indexed through withdrawal and attendance analysis. Braun and Clarke (2006) thematic analysis guided the qualitative analysis.

Results: Caregiver burden significantly declined from baseline through final follow-up. Caregiver resiliency and care recipient QoL were not significantly changed but trended up during the intervention until it dropped at the end of the program. Qualitative data suggests the reversal in resiliency and QoL may be explained by caregivers' increased anxiety as the program ended. Acceptability data indicated caregivers were unanimously highly satisfied with the intervention, desiring to continue participation. Feasibility findings provide recommendations for intervention improvements.

Conclusion: MPAI could reduce caregiver burden and increase resilience for informal caregivers of a person with dementia. Effects drop off quickly at the end of the program, indicating the need for ongoing interventions that provide social support, a respite from the pressures of care recipients' dependency, and the relief that caregivers experience when they perceive benefits to their care recipient's well-being.
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http://dx.doi.org/10.1080/13607863.2021.1891200DOI Listing
March 2021

High Serum Asprosin Levels Are Associated with Presence of Metabolic Syndrome.

Int J Endocrinol 2021 2;2021:6622129. Epub 2021 Mar 2.

Department of Metabolism and Endocrinology, The First Affiliated Hospital of University of South China, Hengyang 421001, Hunan, China.

Objective: Asprosin, a new adipocytokine, has reportedly been associated with glucose release, dyslipidemia, and insulin resistance (IR). However, the relationship of asprosin with metabolic syndrome (MetS) remains unknown. This study aimed to investigate serum asprosin levels in MetS as well as their association with various metabolic parameters in humans.

Methods: A total of 131 consecutive patients with MetS, and 162 age-matched, healthy subjects were recruited for this study. Serum asprosin concentrations were determined using the enzyme-linked immunosorbent assay. Lipid profile, glucose, insulin, and inflammatory markers were also measured.

Results: Serum asprosin levels were higher in subjects with MetS (23.52 [16.70, 32.05] ng/mL) than in controls (16.70 [12.87, 22.38] ng/mL; < 0.01), and they showed an increasing trend with increasing numbers of metabolic components ( for trend < 0.01). In all studied subjects, serum asprosin levels were positively correlated with body mass index, waist circumference, triglycerides, fasting plasma glucose, 2-hour plasma glucose, fasting insulin, homeostatic model assessment of insulin resistance (HOMA-IR) index, interleukin-6, and monocyte chemoattractant protein-1 and negatively correlated with high-density lipoprotein cholesterol ( < 0.05). In multiple linear regression, asprosin was independently and positively correlated with triglyceride and HOMA-IR ( < 0.05). Binary logistic regression revealed that asprosin was independently and positively correlated with the occurrence of MetS and IR, even after controlling for anthropometric variables, lipid profiles, and inflammatory markers.

Conclusion: Asprosin is a potential metabolic-related adipokine and may be related to IR and MetS. This trial was registered with ChiCTR, ChiCTR1800018347.
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http://dx.doi.org/10.1155/2021/6622129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943292PMC
March 2021

Role of vector control in fighting against malaria: Evidence from Ethiopian health-related indicators.

J Infect Public Health 2021 Apr 18;14(4):527-532. Epub 2021 Mar 18.

School of Management, Harbin Institute of Technology, Harbin 150001, PR China. Electronic address:

Background: Due to a high burden imposed on public health from malaria disease in Sub-Saharan Africa, the vector control strategy is a significant concern. Despite the implementation of malaria control interventions in Ethiopia, it remains a major public health problem. Moreover, none of the prior researches was conducted in this title specifically. Therefore, this study investigates the impact of vector control interventions on malaria based on panel data of 10 malaria endemic-regions from 2000 to 2018.

Methods: A reflexive analysis study based on before-and-after assessment was used to evaluate the impact of vector control interventions on malaria with a difference-in-difference approach, representing Period I for before and Period II for after strategic intervention. The random-effect model was also employed to explore the direct relationship between the study variables. The data exported to Stata version 13.0 for analysis.

Results: The study results suggest that the negative relationship between intervention strategy and malaria cases reported in comparison with its counterfactual, showing the increase in malaria cases during Period II comparing to Period I. The study explores a remarkable achievement on the decline in mean malaria-related death in all regions after the implementation of the strategy. Furthermore, a significant relationship between indoor residual spraying, insecticide-treated mosquito nets, and malaria was demonstrated within the strategic periods.

Conclusion: Better results achieved in Period I on mean malaria cases. The results of Period II showed a decline in mean malaria related-death, which was encouraging. The study calls for a supplementary strategy to align with the existing program. The study demonstrates the need for extra efforts on the implementation of the programme and progress about malaria.
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http://dx.doi.org/10.1016/j.jiph.2020.12.002DOI Listing
April 2021

A novel technique to manage internal carotid artery injury in endoscopic endonasal skull base surgery in the premise of proximal and distal controls.

Neurosurg Rev 2021 Mar 18. Epub 2021 Mar 18.

Department of Neurosurgery, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, China.

Intraoperative internal carotid artery injury is one of the most daunting complications in endoscopic skull base surgery. This paper proposed a novel technique to manage ICA injury after proximal and distal controls. The appropriate block sites together with the proximal and distal controls of ICA were demonstrated in six injected cadaveric specimens. The surgical outcomes of five patients with intraoperative ICA injury and managed with this concept were retrospectively reviewed. Five block sites for vascular control could be identified in all six specimens, including (1) distal to the distal dural ring, (2) proximal to the proximal dural ring, (3) anterior genu of the parasellar ICA, (4) the upper third of the paraclival ICA, and (5) just above the foramen lacerum. Both proximal and distal controls of ICA were achieved by using the block sites in combination. Gross tumor resection was achieved in all five cases after the intraoperative ICA injury was successfully managed. Three coping techniques were used, including direct coagulation to seal (three cases), endoscopic suture (one case), and coagulation to sacrifice (one case). Focal brainstem infarction occurred in one case, one patient died of intracranial infection, and the other three cases had no sequelae. No pseudoaneurysm occurred in all patients. Except the sacrificed ICA, the other ICA was intact during follow-up. It is technically feasible to manage ICA injuries after proximal and distal controls during EEA surgeries. The surgical outcomes from our case series supported the use of this novel technique.
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http://dx.doi.org/10.1007/s10143-021-01517-1DOI Listing
March 2021

Somatic MAP3K3 and PIK3CA mutations in sporadic cerebral and spinal cord cavernous malformations.

Brain 2021 Mar 17. Epub 2021 Mar 17.

State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Cavernous malformations (CMs) affecting the central nervous system occur in approximately 0.16% to 0.4% of the general population. The majority (85%) of the CMs are in a sporadic form, but the genetic background of sporadic CMs remains enigmatic. Of the 81 patients, 73 (90.1%) patients were detected carrying somatic missense variants in 2 genes: MAP3K3 and PIK3CA by whole-exome sequencing (WES). The mutation spectrum correlated with lesion size (P = 0.001), anatomical distribution (P < 0.001), MRI appearance (P = 0.004) and haemorrhage events (P = 0.006). PIK3CA mutation was a significant predictor of overt haemorrhage events (P = 0.003, OR = 11.252, 95% CI = 2.275-55.648). Enrichment of endothelial cell (EC) population was associated with a higher fractional abundance of the somatic mutations. Overexpression of the MAP3K3 mutation perturbed angiogenesis of EC models in vitro and zebrafish embryos in vivo. Distinct transcriptional signatures between different genetic subgroups of sporadic CMs were identified by single-cell RNA-sequencing (scRNA-seq) and verified by pathological staining. Significant apoptosis in MAP3K3 mutation carriers and overexpression of GDF15 and SERPINA5 in PIK3CA mutation carriers contributed to their phenotype. We identified activating MAP3K3 and PIK3CA somatic mutations in the majority (90.1%) of sporadic CMs and PIK3CA mutations could confer a higher risk for overt haemorrhage. Our data provide insights into genomic landscapes, propose a mechanistic explanation and underscore the possibility of a molecular classification for sporadic CMs.
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http://dx.doi.org/10.1093/brain/awab117DOI Listing
March 2021

Neuroendoscopic surgery for neuroendocrine cancer of the skull base.

Neuro Endocrinol Lett 2021 Jan;41(6):296-300

Department of Neurosurgery, The First Affiliated Hospital of Medical College, Shihezi University, Shihezi, China.

Background: Neuroendocrine cancer is an extremely rare malignant tumor that originates from the nervous and the endocrine systems. This type of cancer can exist in almost any organ, although it is mainly found in the lung and gastrointestinal system according to current clinical reports. It is rarely found in the skull base, including primary and secondary neuroendocrine cancers. Therefore, diagnosis and treatment face a huge challenge.

Case Description: A 50-year-old female patient was introduced. She was admitted to the hospital due to persistent headaches, accompanied by nausea, vomiting, and decreased vision. Her case was primarily considered as a skull base malignant tumor based on clinical manifestations, imaging, and hormonal examinations. The patient then subsequently underwent neuroendoscopic surgery to remove the skull base tumor and repair cerebrospinal fluid leakage repair. The patient suffered from complications such as ghosting of the right eye after surgery, and she was given vitamin B1 orally. Pathological examination results show that the patient had neuroendocrine cancer (originated from sinus). We followed up the patient 2 months and 6 months after operation. At present, the patient recovered well, had no headache, and her spirit was significantly better than that before operation.

Conclusions: Cranial neuroendocrine cancer has diverse clinical manifestations. CgA, Syn, Ki-67, CD56, and ACTH are important reference indicators for the diagnosis of neuroendocrine cancer. Neuroendoscopic transsphenoidal approach is a safe and effective surgical method.
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January 2021

[Related factors for bile duct infection after surgical treatment of biliary dilatation].

Zhonghua Wai Ke Za Zhi 2021 Apr 1;59(4):284-288. Epub 2021 Apr 1.

Department of General Surgery,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China.

To analyze the related factors of bile duct infection in patients with biliary dilatation in the short and long term after operation. The data of the patients with biliary dilatation admitted in Peking Union Medical College Hospital between May 2012 and October 2020 were analyzed retrospectively. A total of 121 patients were enrolled in the study. There were 21 males(17.4%) and 100 females(82.6%),with age of (40.5±15.3) years(range: 18 to 80 years). Short-term infection was defined as bile duct infection occured within 30 days after operaion; long-term infection was defined as bile duct infectiion occured 30 days after operation The relationship between bile duct infection and clinicopathologic biliary dilatation features were analyzed using univariate and multivariate analyses. There were 85 (70.2%),1 (0.8%), 32 (26.4%) and 3 (2.5%) patients with Todani type Ⅰ,Ⅲ,Ⅳ and Ⅴ, respectively. The mean follow-up time was (55.2±28.6) months (range: 1 to 101 months). There were 18 and 37 patients had short-term and long-term bile duct infection after surgery,respectively. Postoperative complications occurred in 18 patients and included ascites(=6),biliary fistula(=4),pancreatic fistula(=2),gastroparesis (2),pleural effusion(=1),abdominal infection(=1),non-healing wound(=1),and pancreatitis(=1). Univariate analysis showed that preoperative history of bile duct infection,hilar anastomosis and Todani types were related factors for short-term bile duct infection,and postoperative complication was a related factor for long-term bile duct infection. Multivariate analysis showed that hilar anastomosis(=6.228,95%: 1.884-20.586,=0.003) and preoperative history of bile duct infection(=3.701,95%: 1.137-12.043,=0.030) were independent related factors for short-term bile duct infection after biliary dilatation operation,and age ≥45 years (=2.261,95%:1.004-5.093,=0.049) and postoperative complication (=3.131,95%:1.094-8.958,=0.033) were independent related factors for long-term bile duct infection after biliary dilatation operation. Hilar anastomosis and preoperative history of bile duct infection are independent related factors for short-term bile duct infection after biliary dilatation operation,and ≥45 years old and postoperative complication are independent related factors for long-term bile duct infection after biliary dilatation operation.
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http://dx.doi.org/10.3760/cma.j.cn112139-20201229-00890DOI Listing
April 2021

The Prognostic Value of the CA19-9/TBIL Ratio in Patients with Biliary Tract Cancers (BTCs): A Retrospective Study.

J Oncol 2021 23;2021:5829893. Epub 2021 Feb 23.

Department of General Surgery, Peking Union Medical College Hospital, Beijing 100730, China.

Background: Incidence of biliary tract cancers (BTCs) in China is high, and surgery is the only curative option. Preoperative CA19-9 has been identified as a predictor for survival in patients with resectable BTCs, but more potential predictors need to be studied. This retrospective study aimed to establish the prognostic significance of CA19-9/TBIL ratio (CTR) in patients with BTCs.

Methods: A retrospective analysis was performed in patients who were diagnosed with BTCs and received surgical resection between 2013 and 2018 at PUMCH. Demographic and clinical parameters were collected. Preoperative CA19-9 and CTR were classified as elevated (>58.6 and >0.83) according to the receiver operating characteristic (ROC) analysis. Demographic and clinical parameters were compared between the groups using Student's -test, chi-square, or Fisher's exact test. Survival analysis was performed by the Kaplan-Meier methods, and the relationship between variables and survival was assessed by the log-rank test. Cox regression analysis was conducted to identify potential risk factors for overall survival.

Results: In total, 109 participants were involved in the final analysis. The overall survival rate was 18.0% at 5 years, with a median survival duration of 1.58 years. The Kaplan-Meier analysis indicated that higher CTR was associated with shorter OS (15 vs. 50, < 0.01). Univariate survival analysis identified TNM staging, CA19-9, and CTR as statistically significant prognostic factors. In a multiple Cox analysis, only CTR was proved as a significantly independent prognostic factor.

Conclusion: CTR acts as an independent prognostic predictor for patients with biliary tract cancer.
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http://dx.doi.org/10.1155/2021/5829893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925024PMC
February 2021

Rare rewards amplify dopamine responses.

Nat Neurosci 2021 Apr 8;24(4):465-469. Epub 2021 Mar 8.

Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA.

Dopamine prediction error responses are essential components of universal learning mechanisms. However, it is unknown whether individual dopamine neurons reflect the shape of reward distributions. Here, we used symmetrical distributions with differently weighted tails to investigate how the frequency of rewards and reward prediction errors influence dopamine signals. Rare rewards amplified dopamine responses, even when conventional prediction errors were identical, indicating a mechanism for learning the complexities of real-world incentives.
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http://dx.doi.org/10.1038/s41593-021-00807-7DOI Listing
April 2021

Exosomal connexin 43 regulates the resistance of glioma cells to temozolomide.

Oncol Rep 2021 Apr 2;45(4). Epub 2021 Mar 2.

Department of Pharmacology, School of Pharmaceutical Science, Nanchang University, Nanchang, Jiangxi 330006, P.R. China.

Glioblastoma is the most common and aggressive brain tumor and it is characterized by a high mortality rate. Temozolomide (TMZ) is an effective chemotherapy drug for glioblastoma, but the resistance to TMZ has come to represent a major clinical problem, and its underlying mechanism has yet to be elucidated. In the present study, the role of exosomal connexin 43 (Cx43) in the resistance of glioma cells to TMZ and cell migration was investigated. First, higher expression levels of Cx43 were detected in TMZ‑resistant U251 (U251r) cells compared with those in TMZ‑sensitive (U251s) cells. Exosomes from U251s or U251r cells (sExo and rExo, respectively) were isolated. It was found that the expression of Cx43 in rExo was notably higher compared with that in sExo, whereas treatment with rExo increased the expression of Cx43 in U251s cells. Additionally, exosomes stained with dioctadecyloxacarbocyanine (Dio) were used to visualized exosome uptake by glioma cells. It was observed that the uptake of Dio‑stained rExo in U251s cells was more prominent compared with that of Dio‑stained sExo, while Gap27, a gap junction mimetic peptide directed against Cx43, alleviated the rExo uptake by cells. Moreover, rExo increased the IC of U251s to TMZ, colony formation and Bcl‑2 expression, but decreased Bax and cleaved caspase‑3 expression in U251s cells. Gap27 efficiently inhibited these effects of rExo on U251s cells. Finally, the results of the wound healing and Transwell assays revealed that rExo significantly enhanced the migration of U251s cells, whereas Gap27 significantly attenuated rExo‑induced cell migration. Taken together, these results indicate the crucial role of exosomal Cx43 in chemotherapy resistance and migration of glioma cells, and suggest that Cx43 may hold promise as a therapeutic target for glioblastoma in the future.
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http://dx.doi.org/10.3892/or.2021.7995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934218PMC
April 2021

The Impact of US Nurses' Personal Religious and Spiritual Beliefs on Their Mental Well-Being and Burnout: A Path Analysis.

J Relig Health 2021 Feb 25. Epub 2021 Feb 25.

Center for Whole-Person Research, AdventHealth, 301 E. Princeton Street, Orlando, FL, 32804, USA.

This study addresses the gap in the literature regarding the impact of nurses' personal religious and spiritual beliefs on their mental well-being and burnout. A model of the association between these factors was tested based on surveys of 207 nurses located in southeastern USA and analyzed to determine the association between religion/spirituality, mental well-being, and burnout. A path analysis supported a model in which, through its positive impact on mental well-being, religion/spirituality was negatively associated with emotional exhaustion and depersonalization and positively associated with personal accomplishment.
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http://dx.doi.org/10.1007/s10943-021-01203-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7905975PMC
February 2021

Diagnosis, clinical characteristics, and outcomes of COVID-19 patients from a large healthcare system in northern New Jersey.

Sci Rep 2021 02 23;11(1):4389. Epub 2021 Feb 23.

Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA.

New Jersey was an early epicenter for the COVID-19 pandemic in the United States, yet information on hospitalized COVID-19 patients from this area is scarce. This study aimed to provide data on demographics and clinical features of a hospitalized patient population who were confirmed with infection by our in-house (CDI) real-time reverse-transcription polymerase chain reaction (RT-PCR) test. We included consecutive patients who were admitted to Hackensack Meridian Health system hospitals with laboratory-confirmed diagnoses of COVID-19 at Hackensack University Medical Center by the CDI virus test between March 12, 2020, and April 8, 2020. Clinical data and viral testing results were collected and analyzed for characteristics associated with outcomes, as well as the correlation with viral load. A total of 722 patients were included in the study, with a median age of 63 (interquartile range (IQR), 51-75) and 272 (37.7%) females. Mortality of this case series was 25.8%, with a statistically significant linear increase observed from age 40 to ≥ 80 by 10-year intervals. Viral load, as indicated by the cycle of threshold (Ct) values from the RT-PCR test, was significantly higher in the oldest patient group (≥ 80), and inversely correlated with survival. This is the first report to describe the clinical characteristics and outcomes in a large hospitalized COVID-19 patient series from New Jersey. Findings from this study are valuable to the ongoing response of both nationwide healthcare networks and the medical research community.
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http://dx.doi.org/10.1038/s41598-021-83959-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7902820PMC
February 2021

Long Noncoding RNA LINC00526 Represses Glioma Progression via Regulating miR-5581-3p/BEX1.

J Oncol 2021 4;2021:8171250. Epub 2021 Feb 4.

Department of Neurosurgery, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China.

The roles of long noncoding RNAs (lncRNAs) in regulating glioma progression have been widely recognized in recent years. This work was to investigate the roles and associated mechanisms of LINC00526 in glioma progression. LINC00526 expression in glioma tissues and cells and their normal counterparts was measured with quantitative real-time polymerase chain reaction method. Functions of LINC00526 in glioma were investigated with experiments. Moreover, competitive RNA (ceRNA) theory was employed to understand mechanisms of action of LINC00526 in glioma. LINC00526 was found to be decreased in glioma tissues and cell lines compared with their normal counterparts. Silencing the expression of LINC00526 promotes, while forcing its expression, inhibits glioma cell growth and invasion. Mechanism analyses showed LINC00526 functions as a sponge for microRNA-5581-3p (miR-5581-3p) to regulate brain-expressed X-linked 1 (BEX1) expression and, in the end, affects glioma progression. Collectively, our study indicated LINC00526 serves as a tumor-suppressive lncRNA and directly regulates miR-5581-3p/BEX1 axis in glioma.
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http://dx.doi.org/10.1155/2021/8171250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878094PMC
February 2021

Coronary angiography-derived contrast fractional flow reserve.

Catheter Cardiovasc Interv 2021 Feb 15. Epub 2021 Feb 15.

Department of Cardiology, Peking University First Hospital, Beijing, China.

Background: Based on coronary angiography and mean aortic pressure, a specially designed computational flow dynamics (CFD) method is proposed to determine contrast fractional flow reserve (cFFR) without using invasive pressure wire. This substudy assessed diagnostic performance of coronary angiography-derived cFFR in catheterization laboratory, based on a previous multicenter trial for online assessment of coronary angiography-derived FFR (caFFR).

Methods: Patients with diagnosis of stable angina pectoris or unstable angina pectoris were enrolled in six centers. Wire-based FFR was measured in coronary arteries with 30-90% diameter stenosis. Offline angiography-derived cFFR was computed in blinded fashion against the wire-based FFR and caFFR at an independent core laboratory.

Results: A total of 330 patients were enrolled to fulfill inclusion/exclusion criteria from June 26 to December 18, 2018. Offline angiography-derived cFFR and wire-based FFR results were compared in 328 interrogated vessels. The statistical analysis showed the highest diagnostic accuracy of 89.0 and 86.6% for angiography-derived cFFR with a cutoff value of 0.94 and 0.93 against the wire-based FFR with a cutoff value of 0.80 and 0.75, respectively. The corresponding sensitivity and specificity were 92.2 and 87.3% for the cutoff value of 0.94 and 80.0 and 88.4% for the cutoff value of 0.93, which are similar to those against the caFFR. The receiver-operating curve has area under the curve of 0.951 and 0.972 for the wire-based FFR with the cutoff value of 0.80 and 0.75, respectively.

Conclusions: Coronary angiography-derived cFFR showed higher accuracy, sensitivity, and specificity against wired-based FFR and caFFR. Hence, angiography-derived cFFR could enhance the hemodynamic assessment of coronary lesions.
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http://dx.doi.org/10.1002/ccd.29558DOI Listing
February 2021

LncRNA FER1L4 Promotes Oral Squamous Cell Carcinoma Progression via Targeting miR-133a-5p/Prx1 Axis.

Onco Targets Ther 2021 4;14:795-806. Epub 2021 Feb 4.

Department of Stomatology, The First Affiliated Hospital of Xi'an Jiaotong University, Xian, Shanxi, 710061, People's Republic of China.

Background: Oral squamous cell carcinoma (OSCC) is a common cancer especially young people in the world. The long non-coding RNA Fer-1-like protein 4 (FER1L4) has been reported to be closely associated with the progression of various human cancers. However, the role of FER1L4 in OSCC remains unclear.

Methods: The expression level of FER1L4 in OSCC tissues and cancer cell lines was detected by using quantitative real-time polymerase chain reaction (qRT-PCR). Cell proliferation was evaluated by cell counting kit-8 (CCK-8) assay and EdU staining assay. Cell invasion and migration were evaluated by Transwell assay. Cell apoptosis was detected by flow cytometry. Luciferase reporter assay was performed to determine the targeting relationship between FER1L4, miR-133a-5p and Prx1. The protein expression of Prx1 was detected by Western blot. In addition, a xenograft tumor model in vivo was constructed to confirm the function of FER1L4.

Results: FERIL4 was significantly upregulated in OSCC tissues and cancer cell lines. Moreover, high level of FER1L4 predicted a poor prognosis of OSCC patients. Silencing of FER1L4 not only significantly inhibited cell growth, invasion, migration and induced apoptosis in SCC-9 and HN4 cells in vitro, but also effectively suppressed the tumorigenesis of OSCC cells in vivo. Knockdown of FER1L4 significantly enhanced the expression of miR-133a-5p by sponging it, and then downregulated Prx1 expression.

Conclusion: Our study elucidated a new mechanism of lncRNA FER1L4 that promoting OSCC progression by directly targeting miR-133a-5p/Prx1 axis and provided novel therapeutic targets for OSCC.
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http://dx.doi.org/10.2147/OTT.S277351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7869715PMC
February 2021

ALK-rearranged squamous cell carcinoma of the lung.

Thorac Cancer 2021 04 9;12(7):1106-1114. Epub 2021 Feb 9.

Department of Medical Oncology, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China.

Background: ALK rearrangement is a very rare subset of squamous cell carcinoma (SCC) and one of the clinical features in patients is lack of data. Here, we report eight patients diagnosed with SCC of the lung harboring ALK rearrangement.

Methods: We collected primary NSCLC samples at the Beijing Chest Hospital between January 2012 and December 2018 for Ventana (D5F3) immunohistochemical detection. Among the 148 patients was diagnosed ALK-rearranged non small cell lung cancer (NSCLC), only eight cases was SCC. We collected patients information from electronic patent records (EPRs).

Results: The eight cases of SCC were diagnosed by immunohistochemistry (IHC). Two were given crizotinib as second-line therapy. One patient had stable disease (SD) and progression-free survival (PFS) of six months. The other patient had progressive disease (PD) but PFS was only one month. The side effects were tolerable. This report identified 31 cases of ALK rearrangement in SCC patients from a literature search (including the eight patients in this study). These fusion genes are often seen in a younger age group (mean age: 55.6 years) and non-smokers (18/31, 58.1%). A total of 20 cases received an ALK inhibitor as first- or second-line treatment which included 11 with a partial response (PR), four with SD, and five with PD. The DCR and ORR was 75.0% (15/20) and 55.0% (11/20), respectively. The median duration time of therapy was 6.4 ± 4.4 months.

Conclusions: Patients with ALK-rearranged SCC obtained clinical benefit from ALK-inhibitor therapy, especially those who were non-smokers and whose tumors had been identified by IHC+/FISH+.
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http://dx.doi.org/10.1111/1759-7714.13818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8017260PMC
April 2021

Effects of a Trans-Theoretical Model-Based Health Education Program on the Management of Cognitive Dysfunction in Older Adults With Mild Cognitive Impairment: Study Rationale and Protocol Design for a Randomized Controlled Trial.

Front Psychiatry 2020 13;11:616420. Epub 2021 Jan 13.

School of Medicine, Huzhou University, Huzhou, China.

Recent studies have confirmed that the management of cognitive dysfunction produces considerable positive effects in individuals with mild cognitive impairment (MCI), however, compliance with participation in various cognitive dysfunction management strategies remains scant in older adults with MCI. Health education programs can improve the level of knowledge of the disease effectively, though it remains unclear as to whether health education programs are sufficient to promote behavior changes of older adults with MCI in the community. The study aims to provide insight into the effect of a trans-theoretical Model (TTM)-based health education program on increasing knowledge about mild cognitive impairment (MCI), compliance in cognitive dysfunction management, and other cognition-related health outcomes (general cognitive function, sleep quality, depression symptoms, apathy symptoms) for older adults with MCI. This study is a single-blinded, randomized, prospective clinical trial. We will recruit 132 participants with MCI who will be randomly assigned to a TTM-based health education group and a standard health education group in a ratio of 1:1. The intervention group will receive a TTM-based health education program (1 session/week, 4-560 min/session for 8 weeks), while the control group will receive standard health education. Assessors blinded to participant allocation will conduct baseline, post-intervention, and 3-month follow-up assessments. Statistical analyses will consist of the Wilcoxon test, the Chi-square test, the -test, and 2 (group) × 3 (time) ANOVA with a 5% cut-off for significance. Supposing the TTM-based health education program will provide validated community-based cognitive dysfunction management strategies for older adults with MCI, this would be a feasible approach to improve the compliance of participation in cognitive dysfunction management and the cognition-related health outcomes. ChiCTR1900028351. Registered on December 19, 2019. http://www.chictr.org.cn/edit.aspx?pid=47223&htm=4.
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http://dx.doi.org/10.3389/fpsyt.2020.616420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838522PMC
January 2021

The Subchronic Toxic Effects of in Normal Rats.

Biomed Res Int 2020 28;2020:4521586. Epub 2020 Dec 28.

Jiangxi University of Chinese Medicine, Nanchang 330004, China.

Background: The aim of this work was to study the toxic effects and target organs of Mosla chinensis Maxim (MCM) in rats and provide theoretical basis for clinical medication.

Methods: The subchronic toxicity study was conducted on 60 male and female SD rats using the fixed-dose method for the treatment groups and 20 male and female SD rats for the control. At the subchronic toxicity study, the water extract of MCM with fixed doses of 0.2 g/kg/day, 2 g/kg/day, and 20 g/kg/day was administered for 90 days intragastric, and the control group was given the same amount of distilled water. After 90 days, the general conditions of the rats were observed. Assessment on safety of the extract was conducted by a subchronic toxicity test which mainly examined alteration occurrence in gut flora and urine metabolism.

Results: There was no significant difference in physical signs, reactivity, and stool characteristics in the four groups. Compared with the control group, the number of red blood cells in the male 2 g/kg/day group and the female 0.2 g/kg/day group was significantly different ( < 0.05). The detection of serum biochemical indicators showed that MCM has an effect on liver and kidney function but has no physiological significance. The level of low-density lipoprotein in male rats was lower than that in the control group ( < 0.05). Compared with the control group, the blood glucose levels of female rats in the 0.2 g/kg/day, 2 g/kg/day, and 20 g/kg/day groups were significantly increased ( < 0.05). As far as the diversity of intestinal flora is concerned, feeding MCM for 90 days has an influence on the distribution of intestinal flora. The content of lactic acid bacteria increased, and the ratio of hard bacteria to Bacteroides (f/b) was also affected, but there was no significant difference.

Conclusions: These findings showed that the long-term intragastric administration of the MCM is safe to use within its dose recommendation. But it could have a slight effect on the metabolism of uric acid by changing the composition of intestinal flora and affecting the metabolism of tryptophan.
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http://dx.doi.org/10.1155/2020/4521586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7814957PMC
December 2020

Design of mmWave Directional Antenna for Enhanced 5G Broadcasting Coverage.

Sensors (Basel) 2021 Jan 22;21(3). Epub 2021 Jan 22.

School of Electronics and Information Engineering, Beihang University, Beijing 100000, China.

5G mmWave broadcasting is considered to be the main method of future broadcasting. However, the mmWave transmission has a large space loss, especially in tunnels. In order to compensate for the attenuation of the broadcast signal, a directional horn antenna is designed in this paper. Substrate integrated waveguide (SIW) technology, dual-element arrays and extension structures are used to improve the antenna structure and achieve good directional characteristics. The multi-objective genetic algorithm (MOGA) is used to optimize the antenna parameters and improve optimization efficiency. Ultimately, the whole antenna was 28.2 mm in length and 28.6 mm in width, and the FR4 material, with a relative permittivity of 4.4, was used as a dielectric plate. The maximum gain of the antenna is 8.06 dB, and the bandwidth with gain greater than 6.5 dB is nearly 2 GHz. Antenna performance simulation and test results show that the extended semicircular structure is beneficial in enhancing the directional radiation of the antenna. This provides a reference method for directional antennas applied to 5G millimeter wave bands to increase gain and narrow beams.
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http://dx.doi.org/10.3390/s21030746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865306PMC
January 2021

HDAC inhibition results in widespread alteration of the histone acetylation landscape and BRD4 targeting to gene bodies.

Cell Rep 2021 Jan;34(3):108638

Department of Genetics, Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Pediatrics, University of North Carolina, Chapel Hill, NC 27514, USA. Electronic address:

Histone acetylation levels are regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs) that antagonistically control the overall balance of this post-translational modification. HDAC inhibitors (HDACi) are potent agents that disrupt this balance and are used clinically to treat diseases including cancer. Despite their use, little is known about their effects on chromatin regulators, particularly those that signal through lysine acetylation. We apply quantitative genomic and proteomic approaches to demonstrate that HDACi robustly increases a low-abundance histone 4 polyacetylation state, which serves as a preferred binding substrate for several bromodomain-containing proteins, including BRD4. Increased H4 polyacetylation occurs in transcribed genes and correlates with the targeting of BRD4. Collectively, these results suggest that HDAC inhibition functions, at least in part, through expansion of a rare histone acetylation state, which then retargets lysine-acetyl readers associated with changes in gene expression, partially mimicking the effect of bromodomain inhibition.
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http://dx.doi.org/10.1016/j.celrep.2020.108638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886050PMC
January 2021

Examining Associations With Mental, Well-Being and Faith in Nurses (LIFT).

J Nurs Adm 2021 Feb;51(2):106-113

Author Affiliation: Research Scientist (Ms Harris, Dr Green, and Dr Tao) and Scientific Director of Nursing, Population Health, and Academic Research (Dr Robinson), Center for Whole-Person Research AdventHealth, Orlando, Florida.

Objective: The aim of this study was to explore the association between religion/spirituality (r/s) and mental health outcomes in hospital-based nursing staff.

Background: The relationship between r/s and health has been studied extensively. Most frequently, r/s has been studied in association with mental health outcomes, including depression, anxiety, and distress among patients. However, hospital-based nurses suffer from the mental health effects of working in high-stress work environments. To date, little research has focused on the relationship between r/s and mental health outcomes in nurses.

Methods: A cross-sectional online survey was completed by 207 nurses from 6 community hospitals.

Results: Approximately half of the nurses sampled identified as religious, whereas nearly 75% identified as spiritual. There were significant associations between measures of r/s and mental health outcomes such as depression, anxiety, and mental well-being.

Conclusions: This whole-person assessment of nurses may inform future retention and engagement strategies focused on faith-based interventions.
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http://dx.doi.org/10.1097/NNA.0000000000000978DOI Listing
February 2021

[Research Advances in the Diagnostic Value of Rapid On-site Evaluation in Endobronchial Ultrasound-guided Transbronchial Needle Aspiration for Lung Cancer].

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2020 Dec;42(6):820-824

Department of Respiratory,Lanzhou University Second Hospital,Lanzhou 730000,China.

Rapid on-site evaluation(ROSE),an auxiliary sampling quality evaluation technology,can be used to evaluate the adequacy and diagnostic category of samples,judge the histological type of lung cancer,and optimize the gene type of lung cancer.Applying ROSE to endobronchial ultrasound-guided transbronchial needle aspiration of suspected lung cancer can improve the puncture success rate and diagnostic rate and reduce complications and puncture attempts.Rose performed via remote cytopathology technology or by trained respiratory specialists may become the future trends.
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http://dx.doi.org/10.3881/j.issn.1000-503X.12183DOI Listing
December 2020

CT-Guided Pulsed Radiofrequency at Different Voltages in the Treatment of Postherpetic Neuralgia.

Front Neurosci 2020 18;14:579486. Epub 2020 Dec 18.

Department of Pain Management, Shengjing Hospital of China Medical University, Shenyang, China.

Background: Postherpetic neuralgia (PHN) is a form of long-lasting neuropathic pain that can severely affect patients' quality of life. Pulsed radiofrequency (PRF) has been proven to be effective in treating PHN, but the optimal radiofrequency parameters are still not well defined. This retrospective study aimed to compare the efficacy and safety of CT-guided PRF at three different voltages for the treatment of PHN patients.

Methods: This study included 109 patients with PHN involving the thoracic dermatome who were treated in the Department of Pain Management of Shengjing Hospital, China Medical University, from January 2017 to May 2019. They were divided into three groups based on the PRF voltage used: group A (45 V), group B (55 V), and group C (65 V). The PRF therapy (voltage 45, 55, and 65 V) was performed in all patients by targeting the thoracic dorsal root ganglion. After surgery, patients were followed at 3 days, 1 month, 3 months, 6 months, and 12 months. Observation at each follow-up included basic patient characteristics, visual analog scale (VAS), 36-Item Short Form Health Survey (SF-36) scores, patient satisfaction, complications, and side effects.

Results: Visual analog scale scores decreased and SF-36 scores increased for all patients in the three groups at each post-operative time point (1, 3, 6, and 12 months; all < 0.01). Pain relief, improvement in quality of life, and overall satisfaction were more significant for patients in group C than for those in groups A and B at the 3-, 6-, and 12-month follow-ups (all < 0.05). Patients in group B had lower VAS scores and higher overall satisfaction levels than those in group A (both < 0.01). A small number of patients from each group ( ≤ 3) experienced mild intraoperative and post-operative complications, which bore no relationship with group assignment (all > 0.05). At post-operative day 3, patients in group C had skin numbness affecting a larger area than patients in the other two groups (both < 0.05), but the differences were no longer statistically significant at day 30 after the operation. All patients experienced a drop in numbness area of more than 30% after surgery.

Conclusion: Compared with PFR at 45 and 55 V, PFR at 65 V had superior efficacy in treating PNH, with a favorable safety profile.
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http://dx.doi.org/10.3389/fnins.2020.579486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7775564PMC
December 2020

Isobaric tags for relative and absolute quantitation-based proteomics analysis of the effect of ginger oil on bisphenol A-induced breast cancer cell proliferation.

Oncol Lett 2021 Feb 8;21(2):101. Epub 2020 Dec 8.

Experimental Animal Center, Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi 330004, P.R. China.

Several chemicals in the environment, particularly those with estrogenic activity and small amounts (micromolar or lower) of environmental estrogen can cause changes in cell function and interfere with endocrine functions of animals and humans. These compounds enter the human body and increase the load of estrogen in the body, leading to an increasing incidence of estrogen-related tumors in breast cancer, ovarian cancer and endometrial cancer. Previous studies have demonstrated that ginger can inhibit the expression of estrogen receptors, while the bioactive ingredients of ginger sig-nificantly inhibit proliferation and promote the apoptosis of breast cancer cells. In the present study, a quantitative proteomics technique based on relative and absolute quanti-tative isobaric labeling was used to determine the effect of ginger essential oil (GEO) and BPA combined treatment on the proteomic characteristics of MCF-7 cells. In total, 5,084 proteins were detected. Proteins that were upregulated >1.2-fold and downregu-lated by >0.8-fold were differentially expressed. Overall, 528 differentially expressed proteins were identified. Compared with the control group, MCF-7 cells treated with GEO, BPA and GEO-BPA resulted in 45 (14 up- and 31 downregulated), 481 (141 up- and 340 downregulated) and 34 (13 up- and 21 downregulated) differentially ex-pressed proteins, respectively. Compared with the BPA group, MCF- 7 cells treated with GEO-BPA resulted in 210 (117 up- and 93 downregulated) differentially expressed proteins, among the 210 differentially expressed proteins in the GEO-BPA group, 10 proteins were associated with oxidative phosphorylation pathways, while succinate dehydrogenase (ubiquinone) iron-sulfur subunit (SDHB), succinate dehydrogenase cytochrome b560 subunit, mitochondrial (SDHC), cytochrome oxidase subunit 2 and superoxide dismutase (Mn), mitochondrial (SOD2) expression was decreased with GEO-BPA combined treatment. Through the analysis of Gene Ontology and Kyoto Encyclopedia of Genes and Genomes, the cellular localization, functional annotation and biological pathways of differentially expressed proteins were ex-amined. The results indicated that GEO-BPA may act through the oxidative phosphory-lation pathway, decreased the expression of SDHB and SDHC, affected the tricarbox-ylic acid cycle and decreased the expression of SOD2. This may have led to oxidative stress and the death of breast cancer cells, and the SDH signaling pathway may be an important mediator of the inhibitory effects of GEO in MCF-7 breast cancer cells. GEO can inhibit the proliferation of breast cancer MCF-7 cells induced by BPA, and the underlying mechanism may be associated with oxidative phosphorylation. These results may aid the development of future treatment strategies for breast cancer caused by environmental estrogen exposure.
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http://dx.doi.org/10.3892/ol.2020.12362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7751356PMC
February 2021

Lysosome-Mediated Cytotoxic Autophagy Contributes to Tea Polysaccharide-Induced Colon Cancer Cell Death via mTOR-TFEB Signaling.

J Agric Food Chem 2021 Jan 28;69(2):686-697. Epub 2020 Dec 28.

State Key Laboratory of Food Science and Technology, China-Canada Joint Lab of Food Science and Technology (Nanchang), Nanchang University, 235 Nanjing East Road, Nanchang, Jiangxi 330047, China.

Targeting autophagy and lysosome may serve as a promising strategy for cancer therapy. Tea polysaccharide (TP) has shown promising antitumor effects. However, its mechanism remains elusive. Here, TP was found to have a significant inhibitory effect on the proliferation of colon cancer line HCT116 cells. RNA-seq analysis showed that TP upregulated autophagy and lysosome signal pathways, which was further confirmed through experiments. Immunofluorescence experiments indicated that TP activated transcription factor EB (TFEB), a key nuclear transcription factor modulating autophagy and lysosome biogenesis. In addition, TP inhibited the activity of mTOR, while it increased the expression of Lamp1. Furthermore, TP ameliorated the lysosomal damage and autophagy flux barrier caused by Baf A1 (lysosome inhibitor). Hence, our data suggested that TP repressed the proliferation of HCT116 cells by targeting lysosome to induce cytotoxic autophagy, which might be achieved through mTOR-TFEB signaling. In summary, TP may be used as a potential drug to overcome colon cancer.
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http://dx.doi.org/10.1021/acs.jafc.0c07166DOI Listing
January 2021

HI-Light: A Glass-Waveguide-Based "Shell-and-Tube" Photothermal Reactor Platform for Converting CO to Fuels.

iScience 2020 Dec 23;23(12):101856. Epub 2020 Nov 23.

Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY 14853, USA.

In this work, we introduce HI-Light, a surface-engineered glass-waveguide-based "shell-and-tube" type photothermal reactor which is both scalable in diameter and length. We examine the effect of temperature, light irradiation, and residence time on its photo-thermocatalytic performance for CO hydrogenation to form CO, with a cubic phase defect-laden indium oxide, In2O3-x(OH)y, catalyst. We demonstrate the light enhancement effect under a variety of reaction conditions. Notably, the light-on performance for the cubic nanocrystal photocatalyst exhibits a CO evolution rate at 15.40 mmol g hr at 300°C and atmospheric pressure. This is 20 times higher conversion rate per unit catalyst mass per unit time beyond previously reported In2O3-x(OH)y catalyst in the cubic form under comparable operation conditions and more than 5 times higher than that of its rhombohedral polymorph. This result underscores that improvement in photo-thermocatalytic reactor design enables uniform light distribution and better reactant/catalyst mixing, thus significantly improving catalyst utilization.
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http://dx.doi.org/10.1016/j.isci.2020.101856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725935PMC
December 2020