Dr. Tanusree Sen, PhD - University of Pittsburgh - Research Assistant Professor

Dr. Tanusree Sen

PhD

University of Pittsburgh

Research Assistant Professor

PITTSBURGH, PA | United States

Main Specialties: Neurological Surgery, Neurology, Neuropathology, Oncology, Ophthalmology

ORCID logohttps://orcid.org/0000-0002-8970-7007

Dr. Tanusree Sen, PhD - University of Pittsburgh - Research Assistant Professor

Dr. Tanusree Sen

PhD

Introduction

18 years of cellular-molecular biology research experience multiple fields including Neurology, Cancer biology, and Opthalmology. Besides running several different kinds of research projects, supervised other researchers, postdocs and graduate students with wet lab techniques; acquired experience in writing research grants and proposals (NIH and foundation grants); and acquired expertise in teaching BSc (Nursing) students and biotechnology project trainees.
My future plan is to apply my expertise and scientific ideas to obtain novel strategies towards fruitful future collaborations for developing clinically translatable solutions to present day healthcare challenges.

Primary Affiliation: University of Pittsburgh - PITTSBURGH, PA , United States

Specialties:

Research Interests:

Education

Jul 2007
University of Calcutta
PhD
Biochemistry with Neuroscience

Publications

29Publications

707Reads

280Profile Views

380PubMed Central Citations

Sulfhydration of AKT triggers Tau-phosphorylation by activating glycogen synthase kinase 3β in Alzheimer's disease.

Proc Natl Acad Sci U S A 2020 02 12;117(8):4418-4427. Epub 2020 Feb 12.

Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA 15213

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http://dx.doi.org/10.1073/pnas.1916895117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049105PMC
February 2020
9.809 Impact Factor

An augmentation in histone dimethylation at lysine nine residues elicits vision impairment following traumatic brain injury.

Free Radic Biol Med 2019 04 18;134:630-643. Epub 2019 Feb 18.

Department of Neurological Surgery, University of Pittsburgh, 200 Lothrop Street, Scaife Hall, Pittsburgh, 15213, USA. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2019.02.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588499PMC
April 2019
1 Read
5.736 Impact Factor

Integrated transcriptomic and epigenomic analysis of ovarian cancer reveals epigenetically silenced GULP1.

Cancer Lett 2018 10 28;433:242-251. Epub 2018 Jun 28.

Department of Otolaryngology and Head & Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2018.06.030DOI Listing
October 2018
76 Reads
5.621 Impact Factor

Activation of cyclin D1 affects mitochondrial mass following traumatic brain injury.

Neurobiol Dis 2018 10 18;118:108-116. Epub 2018 Jul 18.

Department of Neurological Surgery, University of Pittsburgh, 200 Lothrop Street, Scaife Hall, Pittsburgh 15213, United States. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2018.07.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087674PMC
October 2018
5 Reads
5.080 Impact Factor

Nitrosylation of GAPDH augments pathological tau acetylation upon exposure to amyloid-β.

Sci Signal 2018 03 20;11(522). Epub 2018 Mar 20.

Department of Neurological Surgery, University of Pittsburgh, 200 Lothrop Street, Scaife Hall, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1126/scisignal.aao6765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371980PMC
March 2018
2 Reads
6.280 Impact Factor

Activation of PERK Elicits Memory Impairment through Inactivation of CREB and Downregulation of PSD95 After Traumatic Brain Injury.

J Neurosci 2017 06 18;37(24):5900-5911. Epub 2017 May 18.

Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, and

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http://dx.doi.org/10.1523/JNEUROSCI.2343-16.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473207PMC
June 2017
12 Reads
2 Citations
6.344 Impact Factor

Diet-driven microbiota dysbiosis is associated with vagal remodeling and obesity.

Physiol Behav 2017 05 27;173:305-317. Epub 2017 Feb 27.

Department of Veterinary Biosciences & Diagnostic Imaging, College of Veterinary Medicine, The University of Georgia, Athens, GA 30602, United States. Electronic address:

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http://dx.doi.org/10.1016/j.physbeh.2017.02.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428886PMC
May 2017
38 Reads
9 Citations
2.980 Impact Factor

Isoflurane-induced inactivation of CREB through histone deacetylase 4 is responsible for cognitive impairment in developing brain.

Neurobiol Dis 2016 Dec 17;96:12-21. Epub 2016 Aug 17.

Augusta University, Department of Neuroscience and Regenerative Medicine, 1120 15th Street, CA 2018, Augusta, GA 30907, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2016.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102759PMC
December 2016
4 Reads
3 Citations
5.080 Impact Factor

Treatment with an activator of hypoxia-inducible factor 1, DMOG provides neuroprotection after traumatic brain injury.

Neuropharmacology 2016 08 9;107:79-88. Epub 2016 Mar 9.

Department of Neuroscience and Regenerative Medicine, Augusta University, United States. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2016.03.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912959PMC
August 2016
5 Reads
7 Citations
5.110 Impact Factor

Involvement of epigenetics and EMT-related miRNA in arsenic-induced neoplastic transformation and their potential clinical use.

Cancer Prev Res (Phila) 2015 Mar 13;8(3):208-21. Epub 2015 Jan 13.

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins School of Medicine, Johns Hopkins University, Baltimore, Maryland. Department of Urology, Johns Hopkins University, Baltimore, Maryland. Department of Oncology, Johns Hopkins University, Baltimore, Maryland.

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http://dx.doi.org/10.1158/1940-6207.CAPR-14-0251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355280PMC
March 2015
26 Reads
16 Citations

Cytokine-induced GAPDH sulfhydration affects PSD95 degradation and memory.

Mol Cell 2014 Dec 26;56(6):786-95. Epub 2014 Nov 26.

Department of Neuroscience and Regenerative Medicine, Georgia Regents University, Augusta, GA 30912, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.10.019DOI Listing
December 2014
27 Reads
15 Citations
14.020 Impact Factor

OGDHL is a modifier of AKT-dependent signaling and NF-κB function.

PLoS One 2012 12;7(11):e48770. Epub 2012 Nov 12.

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0048770PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495966PMC
May 2013
18 Reads
13 Citations
3.234 Impact Factor

Behavioral effects of cocaine mediated by nitric oxide-GAPDH transcriptional signaling.

Neuron 2013 May;78(4):623-30

The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.neuron.2013.03.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047707PMC
May 2013
29 Reads
5 Citations
15.054 Impact Factor

VEGF 165 b in the developing vasculatures of the fetal human eye.

Dev Dyn 2012 Mar 31;241(3):595-607. Epub 2012 Jan 31.

Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.

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http://dx.doi.org/10.1002/dvdy.23743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945108PMC
March 2012
12 Reads
14 Citations
2.380 Impact Factor

Hydrogen sulfide-linked sulfhydration of NF-κB mediates its antiapoptotic actions.

Mol Cell 2012 Jan;45(1):13-24

The Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.molcel.2011.10.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261430PMC
January 2012
8 Reads
144 Citations
14.020 Impact Factor

Tumor protein p63/nuclear factor κB feedback loop in regulation of cell death.

J Biol Chem 2011 Dec 20;286(50):43204-13. Epub 2011 Oct 20.

Departments of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.

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http://dx.doi.org/10.1074/jbc.M111.257105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234803PMC
December 2011
13 Reads
7 Citations
4.573 Impact Factor

DeltaNp63alpha confers tumor cell resistance to cisplatin through the AKT1 transcriptional regulation.

Cancer Res 2011 Feb 25;71(3):1167-76. Epub 2011 Jan 25.

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-1481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076926PMC
February 2011
1 Read
21 Citations
9.330 Impact Factor

Regulation of ΔNp63α by NFκΒ.

Cell Cycle 2010 Dec 15;9(24):4841-7. Epub 2010 Dec 15.

Department of Otolaryngology-Head and Neck Surgery, Division of Head and Neck Cancer Research, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3047809PMC
http://dx.doi.org/10.4161/cc.9.24.14093DOI Listing
December 2010
18 Reads
12 Citations

Regulation of p53 family member isoform DeltaNp63alpha by the nuclear factor-kappaB targeting kinase IkappaB kinase beta.

Cancer Res 2010 Feb 9;70(4):1419-29. Epub 2010 Feb 9.

Division of Head and Neck Cancer Research, Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-2613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963198PMC
February 2010
5 Reads
20 Citations
9.330 Impact Factor

Yes-associated protein 1 regulates the stability of DeltaNp63alpha.

Cell Cycle 2010 Jan 13;9(1):162-7. Epub 2010 Jan 13.

Department of Otolaryngology-Head and Neck Surgery, Head and Neck Cancer Research Division, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.4161/cc.9.1.10321DOI Listing
January 2010
4 Reads
4 Citations

ATM kinase is a master switch for the Delta Np63 alpha phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon DNA damage.

Cell Cycle 2008 Sep 15;7(18):2846-55. Epub 2008 Sep 15.

Department of Dermatology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069617PMC
http://dx.doi.org/10.4161/cc.7.18.6627DOI Listing
September 2008
239 Reads
23 Citations

Depolarization and cardiolipin depletion in aged rat brain mitochondria: relationship with oxidative stress and electron transport chain activity.

Neurochem Int 2007 Apr 26;50(5):719-25. Epub 2007 Jan 26.

Department of Biochemistry, Dr. B.C. Roy Post-graduate Institute of Basic Medical Sciences & IPGMER, 244B, Acharya J.C. Bose Road, Calcutta 700020, India.

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http://dx.doi.org/10.1016/j.neuint.2007.01.007DOI Listing
April 2007
3 Reads
9 Citations
3.092 Impact Factor

Gene-specific oxidative lesions in aged rat brain detected by polymerase chain reaction inhibition assay.

Free Radic Res 2007 Mar;41(3):288-94

Department of Biochemistry, Institute of Post Graduate Medical Education & Research, Calcutta, India.

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http://dx.doi.org/10.1080/10715760601083722DOI Listing
March 2007
6 Reads
1 Citation

Leishmania donovani: intracellular ATP level regulates apoptosis-like death in luteolin induced dyskinetoplastid cells.

Exp Parasitol 2006 Nov 16;114(3):204-14. Epub 2006 May 16.

Division of Molecular Parasitology, Indian Institute of Chemical Biology, 4, Raja S.C Mullick Road, Kolkata 700 032, India.

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http://dx.doi.org/10.1016/j.exppara.2006.03.013DOI Listing
November 2006
20 Reads
7 Citations
1.860 Impact Factor

Lipid peroxidation associated cardiolipin loss and membrane depolarization in rat brain mitochondria.

Neurochem Int 2006 Jul 28;49(1):20-7. Epub 2006 Feb 28.

Department of Biochemistry, Dr. B.C. Roy Post-graduate Institute of Basic Medical Sciences & IPGMER, Calcutta, India.

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http://dx.doi.org/10.1016/j.neuint.2005.12.018DOI Listing
July 2006
15 Reads
9 Citations
3.092 Impact Factor

Inhibition of rat brain mitochondrial electron transport chain activity by dopamine oxidation products during extended in vitro incubation: implications for Parkinson's disease.

Biochim Biophys Acta 2005 Jun 14;1741(1-2):65-74. Epub 2005 Apr 14.

Department of Biochemistry, Dr. B.C. Roy Post-graduate Institute of Basic Medical Sciences, 244B, Acharya J.C. Bose Road, Calcutta 700020, India.

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http://dx.doi.org/10.1016/j.bbadis.2005.03.013DOI Listing
June 2005
21 Reads
13 Citations

Dopamine oxidation products inhibit Na+, K+-ATPase activity in crude synaptosomal-mitochondrial fraction from rat brain.

Free Radic Res 2003 Jun;37(6):597-601

Department of Biochemistry, University College of Medicine, Calcutta University, 244B, A.J.C. Bose Road, Calcutta 020, India.

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http://dx.doi.org/10.1080/1071576031000115651DOI Listing
June 2003
3 Reads
3 Citations

Top co-authors

David Sidransky
David Sidransky

Johns Hopkins University School of Medicine

9
Aditi Chatterjee
Aditi Chatterjee

Institute of Bioinformatics

5
Sasanka Chakrabarti
Sasanka Chakrabarti

ICARE Institute of Medical Sciences and Research

5
Uttara Chatterjee
Uttara Chatterjee

Institute of Post Graduate Medical Education and Research

4
Mariana Brait
Mariana Brait

Johns Hopkins University School of Medicine

4
Firoj Hossain Khan
Firoj Hossain Khan

Dr. B.C. Roy Post-graduate Institute of Basic Medical Sciences

3
Sirsendu Jana
Sirsendu Jana

Institute of Post Graduate Medical Education & Research

3
Mohammad Obaidul Hoque
Mohammad Obaidul Hoque

The Johns Hopkins School of Medicine

3