Publications

Urinary neutrophil gelatinase-associated lipocalin and cystatin C compared to the estimated glomerular filtration rate to predict risk in patients with suspected acute myocardial infarction.
Int J Cardiol 2017 Oct 25;245:6-12. Epub 2017 Jul 25.
Division of Cardiology, Department of Internal Medicine III, Goethe University Frankfurt, Germany; German Centre for Cardiovascular Research (DZHK), partner site RheinMain, Frankfurt, Germany; Kerckhoff Heart and Thorax Center, Department of Cardiology, Bad Nauheim, Germany. Electronic address:

Transcriptome-Wide Analysis Identifies Novel Associations With Blood Pressure.
Hypertension 2017 Oct 7;70(4):743-750. Epub 2017 Aug 7.
From the General and Interventional Cardiology, University Heart Center Hamburg, Germany (T.Z., C.M., A.J., M.K., J.T.N., R.B.S., F.O., S.B.); DZHK (German Centre for Cardiovascular Research), Germany (T.Z., C.S., C.M., P.S.W., A.T., A.S., A.K., A.J., M.K., J.T.N., T.K., R.B.S., M.D., T.M., K.J.L., S.B.F., U.L., A.Z., U.V., S.B.); Institute of Human Genetics (K.S., T.M., H.P.), Molecular Epidemiology (C.G., S.W.), and Institute of Epidemiology II (C.G., S.W.), Helmholtz Zentrum München, Germany; Institut für Medizinische Biometrie und Statistik, Universitätsklinikum Schleswig-Holstein, Germany (C.M., A.S., A.Z.); Institute for Translational Genomics and Population Sciences, UCLA Medical Center (S.K., J.I.R., X.G.); Preventive Cardiology and Preventive Medicine (P.S.W.), Institute of Clinical Chemistry and Laboratory Medicine (K.J.L.), and Center for Thrombosis and Hemostasis (P.S.W.), University Medical Center of the Johannes Gutenberg-University Mainz, Germany; Institute for Community Medicine (A.T.) and Department of Internal Medicine B (M.D., S.B.F.), University Medicine Greifswald, Germany; Interfaculty Institute for Genetics and Functional Genomics, University Greifswald, Germany (C.S., T.K., U.V., G.H.); Department of Internal Medicine (D.H., J.D.) and Department of Epidemiology and Prevention (Y.L.), Wake Forest School of Medicine, Winston-Salem, NC; Department of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo Neuromed, Pozzilli IS, Italy (L.I., S.C.); Department of Cardiology and Pneumology, Charite, Universitätsmedizin Berlin, Germany (A.K., U.L.); National Institute for Health and Welfare, Helsinki, Finland (K.K.); Institute for Clinical Diabetology, German Diabetes Center, Duesseldorf, Germany (M.R., M.C.-K., C.H.); Department of Endocrinology and Diabetology, Medical Faculty Düsseldorf, Germany (M.R.); German Center for Diabetes Research (DZD), Munich, Germany (M.R., S.W., M.C.-K., C.H.); Sorbonne Universités, UPMC, INSERM, UMR_S 1166, ICAN Institute for Cardiometabolism and Nutrition, Paris, France (D.-A.T.); Institute of Human Genetics, Technische Universität München, Germany (T.M., P.W., H.P.); ZIK_FunGene, Universität Greifswald, Germany (U.V., G.H.); and Columbia University Medical Center, New York, NY (W.P.).




Relation between Arterial Stiffness and Markers of Inflammation and Hemostasis - Data from the Population-based Gutenberg Health Study.
Sci Rep 2017 Jul 24;7(1):6346. Epub 2017 Jul 24.
Preventive Cardiology and Preventive Medicine, Center for Cardiology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.


Circulating Levels of Interleukin 1-Receptor Antagonist and Risk of Cardiovascular Disease: Meta-Analysis of Six Population-Based Cohorts.
Arterioscler Thromb Vasc Biol 2017 Jun 20;37(6):1222-1227. Epub 2017 Apr 20.
From the Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany (C. Herder, M.C.-K., M.R.); German Center for Diabetes Research (DZD), München-Neuherberg, Germany (C. Herder, M.C.-K., A. Peters, M.R., B.T.); Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany (T.d.l.H.G., C. Huth, A.Z., S.W., C.M., A. Peters, B.T.); German Center for Cardiovascular Research (DZHK), Partner site Munich Heart Alliance, Germany (T.d.l.H.G., W.K.); Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany (S.W.); Tethys Bioscience, Emeryville, CA (J.S.-K., D.P.); National Institute for Health and Welfare, Helsinki, Finland (K.K., A. Pietilä, V.S.); Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands (S.L., A.D., M.A.I.); Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany (B.W.C.B.); Department of Biostatistics and Epidemiology, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, United Kingdom (A.D.); National Institute for Health and Welfare, Turku, Finland (A.J.); Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Institute of Clinical Science B, Queen's University Belfast, United Kingdom (F.K.); UKCRC Centre of Excellence for Public Health (Northern Ireland), Queen's University Belfast, United Kingdom (F.K.); Dalla Lana School of Public Health, University of Toronto, Ontario, Canada (O.S.); Clinic for General and Interventional Cardiology, University Heart Center Hamburg, Germany (T.Z., S.B.); German Center for Cardiovascular Research (DZHK), Partner site Hamburg, Lübeck, Kiel, Germany (T.Z., S.B.); Department of Endocrinology and Diabetology, Medical Faculty, University Hospital Düsseldorf, Germany (M.R.); Deutsches Herzzentrum München, Technische Universität München, Germany (W.K.); and Department of Internal Medicine II-Cardiology, University of Ulm Medical Center, Germany (W.K.).


Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function.
J Clin Invest 2017 May 10;127(5):1798-1812. Epub 2017 Apr 10.

Challenging the 99th percentile: A lower troponin cutoff leads to low mortality of chest pain patients.
Int J Cardiol 2017 Apr 27;232:289-293. Epub 2016 Dec 27.
Department of General and Interventional Cardiology, University Heart Center Hamburg, Martinistrasse 52, 20246 Hamburg, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Martinistrasse 52, 20246 Hamburg, Germany.


Non-coding RNAs in cardiovascular diseases: diagnostic and therapeutic perspectives.
Eur Heart J 2017 Apr 18. Epub 2017 Apr 18.
Department of Cardiology, CBF, CC11, Charite Universitätsmedizin Berlin, Campus Benjamin Franklin, Charite Centrum 11 (Cardiovascular Medicine), Hindenburgdamm 20, 12200 10 Berlin, Germany.



Biomarkers for characterization of heart failure - Distinction of heart failure with preserved and reduced ejection fraction.
Int J Cardiol 2017 Jan 9;227:272-277. Epub 2016 Nov 9.
University Heart Center Hamburg, Department of General and Interventional Cardiology, Hamburg, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany. Electronic address:


Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis.
Am J Hum Genet 2017 Jan 22;100(1):51-63. Epub 2016 Dec 22.
Division of Cardiovascular Medicine, Department of Internal Medicine, Department of Human Genetics, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, USA. Electronic address:



New insights into the genetics of primary open-angle glaucoma based on meta-analyses of intraocular pressure and optic disc characteristics.
Hum Mol Genet 2017 Jan;26(2):438-453
Statistical Genetics, QIMR Berghofer Medical Research Institute, Royal Brisbane Hospital, Brisbane, Australia.

Comparison of HapMap and 1000 Genomes Reference Panels in a Large-Scale Genome-Wide Association Study.
PLoS One 2017 20;12(1):e0167742. Epub 2017 Jan 20.
Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.

Cardiovascular Mortality in Chest Pain Patients: Comparison of Natriuretic Peptides With Novel Biomarkers of Cardiovascular Stress.
Can J Cardiol 2016 Dec 20;32(12):1470-1477. Epub 2016 May 20.
Department of General and Interventional Cardiology, University Heart Center, Hamburg, Germany. Electronic address:



SYNTAX score-0 patients: risk stratification in nonobstructive coronary artery disease.
Clin Res Cardiol 2016 Nov 30;105(11):901-911. Epub 2016 Jun 30.
Department of General and Interventional Cardiology, University Heart Center Hamburg, Martinistr. 52, 20246, Hamburg, Germany.

High-sensitivity troponin and novel biomarkers for the early diagnosis of non-ST-segment elevation myocardial infarction in patients with atrial fibrillation.
Eur Heart J Acute Cardiovasc Care 2016 Oct 12;5(6):419-427. Epub 2015 Oct 12.
Department of General and Interventional Cardiology, University Heart Center, Germany German Center for Cardiovascular research (DZHK), Partner Site Hamburg, Germany





Development of nonfibrotic left ventricular hypertrophy in an ANG II-induced chronic ovine hypertension model.
Physiol Rep 2016 Sep;4(17)
Department of Cardiology-Electrophysiology, cNEP, cardiac Neuro- and Electrophysiology research group University Heart Centre University Hospital Hamburg-Eppendorf, Hamburg, Germany DZHK (German Centre for Cardiovascular Research), Partner Site, Hamburg/Kiel/Lübeck, Germany


Comparison of Cox Model Methods in A Low-dimensional Setting with Few Events.
Genomics Proteomics Bioinformatics 2016 Aug 17;14(4):235-43. Epub 2016 May 17.
Department of General and Interventional Cardiology, University Heart Center Hamburg-Eppendorf, 20246 Hamburg, Germany; German Center for Cardiovascular Research (DZHK), Hamburg/Kiel/Luebeck, Germany.

Antiphospholipid antibodies in a large population-based cohort: genome-wide associations and effects on monocyte gene expression.
Thromb Haemost 2016 Jul 21;116(1):115-23. Epub 2016 Apr 21.
Dr. Karl J. Lackner, Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Mainz, Langenbeckstrasse 1, D-55131 Mainz, Germany, Tel.: +49 6131 177190, E-mail:

Diagnosis of Myocardial Infarction Using a High-Sensitivity Troponin I 1-Hour Algorithm.
JAMA Cardiol 2016 Jul;1(4):397-404
Department of General and Interventional Cardiology, University Heart Center Hamburg, University Hospital Hamburg-Eppendorf, Hamburg, Germany2German Center for Cardiovascular Research, Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany.

Risk factors for heart failure are associated with alterations of the LV end-diastolic pressure-volume relationship in non-heart failure individuals: data from a large-scale, population-based cohort.
Eur Heart J 2016 Jun 7;37(23):1807-14. Epub 2016 Apr 7.
Department of General and Interventional Cardiology, University Heart Center Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany DZHK (German Centre for Cardiovascular Research), Partner site Hamburg/Kiel/Lübeck, Hamburg, Germany.


The Predictive Value of Depressive Symptoms for All-Cause Mortality: Findings From the PRIME Belfast Study Examining the Role of Inflammation and Cardiovascular Risk Markers.
Psychosom Med 2016 May;78(4):401-11
From the UK Clinical Research Collaboration Centre of Excellence for Public Health (Hughes, Patterson, Woodside, Donnelly, Linden, Esquirol, Kee), Queens University of Belfast, Northern Ireland, United Kingdom; Clinic for General and Interventional Cardiology (Hughes, Blankenberg, Zeller), University Heart Centre Hamburg, Hamburg, Germany; German Centre for Cardiovascular Research (DZHK) Partner Site Hamburg/Lübeck/Kiel (Hughes, Blankenberg, Zeller), Germany; MRC Epidemiology Unit (Hughes), University of Cambridge, Cambridge, England, United Kingdom; Department of Psychology (Appleton), Bournemouth University, Dorset, United Kingdom; and UMR 1027 Université Paul Sabatier-CHU (Esquirol), Toulouse, France.



Low Homoarginine Levels in the Prognosis of Patients With Acute Chest Pain.
J Am Heart Assoc 2016 Apr 13;5(4):e002565. Epub 2016 Apr 13.
German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Germany Department of General and Interventional Cardiology, University Heart Center Hamburg-Eppendorf, Hamburg, Germany.

Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes.
Diabetes 2016 Mar 2;65(3):803-17. Epub 2015 Dec 2.
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD Renal Division, Medical Center, University of Freiburg, Freiburg, Germany

Cardiovascular biomarkers in paired maternal and umbilical cord blood samples at term and near term delivery.
Early Hum Dev 2016 Mar 4;94:7-12. Epub 2016 Feb 4.
University Heart Center, Clinic for Pediatric Cardiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.


Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error.
Nat Commun 2016 Mar 29;7:11008. Epub 2016 Mar 29.
Department of Ophthalmology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.

Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels.
Nat Commun 2016 Feb 1;7:10494. Epub 2016 Feb 1.
MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.

Sex-specific differences in genetic and nongenetic determinants of mean platelet volume: results from the Gutenberg Health Study.
Blood 2016 Jan 30;127(2):251-9. Epub 2015 Oct 30.
Center of Thrombosis and Hemostasis, Preventive Cardiology and Medical Prevention, Department of Medicine II, and DZHK, Partner Site Rhein-Main, Mainz, Germany; and.

A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration.
Hum Mol Genet 2016 Jan 10;25(2):358-70. Epub 2015 Nov 10.
Department of Epidemiology,

ADMA, subclinical changes and atrial fibrillation in the general population.
Int J Cardiol 2016 Jan 19;203:640-6. Epub 2015 May 19.
Department of General and Interventional Cardiology, University Heart Center Hamburg-Eppendorf, Germany; DZHK (Deutsches Zentrum fuer Herz-Kreislauf-Forschung e.V.), partner site Hamburg/Kiel/Luebeck, Germany. Electronic address:

ADMA and arginine derivatives in relation to non-invasive vascular function in the general population.
Atherosclerosis 2016 Jan 30;244:149-56. Epub 2015 Oct 30.
Department of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, Germany. Electronic address:

Predictors of leptin concentration and association with cardiovascular risk in patients with coronary artery disease: results from the AtheroGene study.
Biomarkers 2017 May - Jun;22(3-4):210-218. Epub 2016 Jan 15.
b Department of General and Interventional Cardiology , University Heart Center Hamburg , Hamburg , Germany.

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function.
Nat Commun 2016 Jan 21;7:10023. Epub 2016 Jan 21.
NHLBI's Framingham Heart Study and the Center for Population Studies, 73 Mt Wayte Avenue, Suite 2, Framingham, Massachusetts 01702, USA.






SASH1, a new potential link between smoking and atherosclerosis.
Atherosclerosis 2015 Oct 14;242(2):571-9. Epub 2015 Aug 14.
Sorbonne Universités, UPMC, UMR_S 1166-ICAN, Genomics and Pathophysiology of Cardiovascular Diseases, Institute of Cardiometabolism and Nutrition, ICAN, Pitié-Salpêtrière Hospital, F-75013, Paris, France. Electronic address:



Estimation of Values below the Limit of Detection of a Contemporary Sensitive Troponin I Assay Improves Diagnosis of Acute Myocardial Infarction.
Clin Chem 2015 Sep 27;61(9):1197-206. Epub 2015 Jul 27.
Division of Cardiology, Department of Medicine III, Goethe University Frankfurt, Frankfurt, Germany; DZHK (German Centre for Cardiovascular Research), partner site Rhein-Main, Germany;


Predictive value of galectin-3 for incident cardiovascular disease and heart failure in the population-based FINRISK 1997 cohort.
Int J Cardiol 2015 Aug 9;192:33-9. Epub 2015 May 9.
National Institute for Health and Welfare, Department of Chronic Disease Prevention, Helsinki, Finland. Electronic address:

The utility of pregnancy-associated plasma protein A for determination of prognosis in a cohort of patients with coronary artery disease.
Biomark Med 2015 30;9(8):731-41. Epub 2015 Jul 30.
Department of Internal Medicine, Federal Armed Forces Central Hospital, Rübenacher Straße 170, 56072 Koblenz, Germany.


Profile of the Immune and Inflammatory Response in Individuals With Prediabetes and Type 2 Diabetes.
Diabetes Care 2015 Jul 15;38(7):1356-64. Epub 2015 Apr 15.
Center for Thrombosis and Hemostasis, University Medical Center Mainz, Mainz, Germany Preventive Cardiology and Preventive Medicine, Department of Medicine 2, University Medical Center Mainz, Mainz, Germany German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, Germany



High-sensitivity cardiac troponin I and B-type natriuretic Peptide as predictors of vascular events in primary prevention: impact of statin therapy.
Circulation 2015 May 30;131(21):1851-60. Epub 2015 Mar 30.
From Divisions of Cardiovascular (B.M.E., P.M.R.) and Preventive Medicine (B.M.E., R.J.G., P.M.R.), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; University Heart Centre Hamburg, Clinic for General and Interventional Cardiology, Germany (T.Z., S.B.); and German Centre for Cardiovascular Research Partner Site Hamburg/Lübeck/Kiel, Germany (T.Z., S.B.).

Distribution, genetic and cardiovascular determinants of FVIII:c - Data from the population-based Gutenberg Health Study.
Int J Cardiol 2015 21;187:166-74. Epub 2015 Mar 21.
Center for Thrombosis and Hemostasis (CTH), University Medical Center of the Johannes Gutenberg-University Mainz, Germany; Preventive Cardiology and Preventive Medicine, Dept. of Medicine 2, University Medical Center of the Johannes Gutenberg-University Mainz, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Rhine-Main, Mainz, Germany.


Genome-wide association study for refractive astigmatism reveals genetic co-determination with spherical equivalent refractive error: the CREAM consortium.
Hum Genet 2015 Feb 4;134(2):131-46. Epub 2014 Nov 4.
National Human Genome Research Institute, National Institutes of Health, 333 Cassell Drive Suite 1200, Baltimore, MD, 21224, USA.

miRNA-197 and miRNA-223 Predict Cardiovascular Death in a Cohort of Patients with Symptomatic Coronary Artery Disease.
PLoS One 2015 31;10(12):e0145930. Epub 2015 Dec 31.
Department of General and Interventional Cardiology, University Heart Center Hamburg Eppendorf, Hamburg, Germany.


Metabolic signatures of adiposity in young adults: Mendelian randomization analysis and effects of weight change.
PLoS Med 2014 Dec 9;11(12):e1001765. Epub 2014 Dec 9.
Computational Medicine, Institute of Health Sciences, University of Oulu, Oulu, Finland; NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom; Oulu University Hospital, Oulu, Finland; Computational Medicine, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.

Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma.
Nat Genet 2014 Oct 31;46(10):1126-1130. Epub 2014 Aug 31.
Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.


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