Tanja Kuhlmann

Tanja Kuhlmann

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Tanja Kuhlmann

Publications by authors named "Tanja Kuhlmann"

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Stem cell derived oligodendrocytes to study myelin diseases.

Glia 2020 04 21;68(4):705-720. Epub 2019 Oct 21.

Institute of Neuropathology, University Hospital Münster, Münster, Germany.

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http://dx.doi.org/10.1002/glia.23733DOI Listing
April 2020

Oligodendroglial α-synucleinopathy-driven neuroinflammation in multiple system atrophy.

Brain Pathol 2019 05 31;29(3):380-396. Epub 2019 Jan 31.

Department of Molecular Neurology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.

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http://doi.wiley.com/10.1111/bpa.12678
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http://dx.doi.org/10.1111/bpa.12678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850330PMC
May 2019

The K -channel TASK1 affects Oligodendroglial differentiation but not myelin restoration.

Glia 2019 05 9;67(5):870-883. Epub 2019 Jan 9.

Department of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany.

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http://dx.doi.org/10.1002/glia.23577DOI Listing
May 2019

TMEM10 Promotes Oligodendrocyte Differentiation and is Expressed by Oligodendrocytes in Human Remyelinating Multiple Sclerosis Plaques.

Sci Rep 2019 03 5;9(1):3606. Epub 2019 Mar 5.

Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University St., Montreal, Quebec, H3A 2B4, Canada.

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http://dx.doi.org/10.1038/s41598-019-40342-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400977PMC
March 2019

Association between pathological and MRI findings in multiple sclerosis.

Lancet Neurol 2019 Feb;18(2):198-210

Neuroimaging Research Unit and Department of Neurology, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.

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http://dx.doi.org/10.1016/S1474-4422(18)30451-4DOI Listing
February 2019

Maladaptive cortical hyperactivity upon recovery from experimental autoimmune encephalomyelitis.

Nat Neurosci 2018 10 26;21(10):1392-1403. Epub 2018 Sep 26.

Focus Program Translational Neurosciences & Institute of Pathophysiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

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http://www.nature.com/articles/s41593-018-0193-2
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http://dx.doi.org/10.1038/s41593-018-0193-2DOI Listing
October 2018

Blockade of MCAM/CD146 impedes CNS infiltration of T cells over the choroid plexus.

J Neuroinflammation 2018 Aug 22;15(1):236. Epub 2018 Aug 22.

Clinic of Neurology with Institute of Translational Neurology, University of Münster, Albert-Schweitzer-Campus-1, Building A01, 48149, Münster, Germany.

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https://jneuroinflammation.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s12974-018-1276-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106934PMC
August 2018

Single Site Fluorination of the GM Ganglioside Epitope Upregulates Oligodendrocyte Differentiation.

ACS Chem Neurosci 2018 05 7;9(5):1159-1165. Epub 2018 Feb 7.

Institute for Organic Chemistry , Westfälische Wilhelms-Universität Münster , Corrensstrasse 40 , 48149 Münster , Germany.

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http://dx.doi.org/10.1021/acschemneuro.8b00002DOI Listing
May 2018

Deficiency of the BMP Type I receptor ALK3 partly protects mice from anemia of inflammation.

BMC Physiol 2018 Feb 27;18(1). Epub 2018 Feb 27.

Department of Anaesthesiology, Intensive Care and Pain Medicine, University Hospital Muenster, Albert-Schweitzer Campus 1, Building A1, 48149, Muenster, Germany.

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http://dx.doi.org/10.1186/s12899-018-0037-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389079PMC
February 2018

Achievements and obstacles of remyelinating therapies in multiple sclerosis.

Nat Rev Neurol 2017 Dec 17;13(12):742-754. Epub 2017 Nov 17.

Department of Anatomy and Neuroscience and Melbourne Neuroscience Institute, University of Melbourne, 30 Royal Parade, Parkville, Victoria 3010, Australia.

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http://dx.doi.org/10.1038/nrneurol.2017.139DOI Listing
December 2017

Intravenous Iron Carboxymaltose as a Potential Therapeutic in Anemia of Inflammation.

PLoS One 2016 12;11(7):e0158599. Epub 2016 Jul 12.

Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Muenster, University of Muenster, Muenster, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0158599PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942094PMC
July 2017

Deletional tolerance prevents AQP4-directed autoimmunity in mice.

Eur J Immunol 2017 03 25;47(3):458-469. Epub 2017 Jan 25.

Klinikum rechts der Isar, Department of Neurology, Technical University of Munich, Munich, Germany.

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http://dx.doi.org/10.1002/eji.201646855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359142PMC
March 2017

Activation of FXR pathway does not alter glial cell function.

J Neuroinflammation 2017 03 28;14(1):66. Epub 2017 Mar 28.

Institute of Neuropathology, University Hospital Münster, 48149, Münster, Germany.

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http://dx.doi.org/10.1186/s12974-017-0833-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371249PMC
March 2017

An updated histological classification system for multiple sclerosis lesions.

Acta Neuropathol 2017 01 17;133(1):13-24. Epub 2016 Dec 17.

Center for Brain Research, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1007/s00401-016-1653-yDOI Listing
January 2017

Down-regulation of neuronal L1 cell adhesion molecule expression alleviates inflammatory neuronal injury.

Acta Neuropathol 2016 11 20;132(5):703-720. Epub 2016 Aug 20.

Department of Anesthesiology, University Medical Center of the Johannes-Gutenberg-University Mainz, Mainz, Germany.

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http://dx.doi.org/10.1007/s00401-016-1607-4DOI Listing
November 2016

CXCR7 Is Involved in Human Oligodendroglial Precursor Cell Maturation.

PLoS One 2016 7;11(1):e0146503. Epub 2016 Jan 7.

Department of Neurology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0146503PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704822PMC
July 2016

Comparative transcriptome analysis in induced neural stem cells reveals defined neural cell identities in vitro and after transplantation into the adult rodent brain.

Stem Cell Res 2016 05 19;16(3):776-81. Epub 2016 Apr 19.

Institute of Neuropathology, University Hospital Münster, 48149 Münster, Germany; Max Planck Institute for Molecular Biomedicine, 48149 Münster, Germany; Department of Pathology and Cell Biology, Columbia University Medical Center, 10032 New York, USA. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2016.04.015DOI Listing
May 2016

Impaired NK-mediated regulation of T-cell activity in multiple sclerosis is reconstituted by IL-2 receptor modulation.

Proc Natl Acad Sci U S A 2016 May 9;113(21):E2973-82. Epub 2016 May 9.

Department of Neurology, University Hospital Münster, Muenster D-48149, Germany; Cluster of Excellence EXC 1003, Cells in Motion, Westfälische Wilhelms-University, 48149 Muenster, Germany

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http://dx.doi.org/10.1073/pnas.1524924113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889377PMC
May 2016

Functional organization of an Mbp enhancer exposes striking transcriptional regulatory diversity within myelinating glia.

Glia 2016 Jan 28;64(1):175-94. Epub 2015 Oct 28.

Laboratory of Developmental Biology, Ludmer Research and Training Building, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1002/glia.22923DOI Listing
January 2016

Non-steroidal anti-inflammatory drug indometacin enhances endogenous remyelination.

Acta Neuropathol 2015 Aug 6;130(2):247-61. Epub 2015 May 6.

Institute of Neuropathology, University Hospital Münster, Pottkamp 2, 48149, Münster, Germany.

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http://dx.doi.org/10.1007/s00401-015-1426-zDOI Listing
August 2015

Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination.

Nat Neurosci 2015 Apr 23;18(4):511-20. Epub 2015 Feb 23.

1] Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA. [2] Department of Genetics and Genomics, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

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http://dx.doi.org/10.1038/nn.3953DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522902PMC
April 2015

Long-term efficacy of alemtuzumab in polymyositis.

Rheumatology (Oxford) 2015 Mar 30;54(3):560-2. Epub 2014 Dec 30.

Department of Neurology and Institute of Neuropathology, University of Münster, Münster, Germany.

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http://rheumatology.oxfordjournals.org/content/54/3/560.full
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http://www.rheumatology.oxfordjournals.org/cgi/doi/10.1093/r
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http://dx.doi.org/10.1093/rheumatology/keu484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334687PMC
March 2015

Cross-recognition of a myelin peptide by CD8+ T cells in the CNS is not sufficient to promote neuronal damage.

J Neurosci 2015 Mar;35(12):4837-50

Department of Neurology, Research Center Translational Neurosciences, Rhine Main Neuroscience Network (rmn), and Molecular Neurology Group, Max Delbrueck Center for Molecular Medicine Berlin-Buch, 13125 Berlin, Germany, Charité University Medicine Berlin, ECRC, 13125 Berlin, Germany, and

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http://dx.doi.org/10.1523/JNEUROSCI.3380-14.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6705380PMC
March 2015

Limited TCF7L2 expression in MS lesions.

PLoS One 2013 20;8(8):e72822. Epub 2013 Aug 20.

Institute of Neuropathology, University Hospital Münster, Münster, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0072822PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748032PMC
January 2015

Chromatin landscape defined by repressive histone methylation during oligodendrocyte differentiation.

J Neurosci 2015 Jan;35(1):352-65

Department of Neuroscience, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, and

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http://dx.doi.org/10.1523/JNEUROSCI.2606-14.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287153PMC
January 2015

Remyelinating strategies in multiple sclerosis.

Expert Rev Neurother 2014 Nov;14(11):1315-34

Department of Neurology, Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (rmn²), University Medical Center of the Johannes Gutenberg-University of Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany.

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http://dx.doi.org/10.1586/14737175.2014.969241DOI Listing
November 2014

VLA-4 blockade promotes differential routes into human CNS involving PSGL-1 rolling of T cells and MCAM-adhesion of TH17 cells.

J Exp Med 2014 Aug 18;211(9):1833-46. Epub 2014 Aug 18.

Department of Neurology; Department of Anaesthesiology, Intensive Care and Pain Medicine; Institute for Medical Physics and Biophysics; Institute of Neuropathology; and Institute of Physiological Chemistry and Pathobiochemistry, University of Münster, 48149 Münster, Germany

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http://dx.doi.org/10.1084/jem.20140540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144733PMC
August 2014

Differential loss of KIR4.1 immunoreactivity in multiple sclerosis lesions.

Ann Neurol 2014 Jun 21;75(6):810-28. Epub 2014 May 21.

Department of Neurology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.

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http://dx.doi.org/10.1002/ana.24168DOI Listing
June 2014

Embryonic stem cell-derived neural progenitors as non-tumorigenic source for dopaminergic neurons.

World J Stem Cells 2014 Apr;6(2):248-55

Mei-Chih Liao, Mihaela Diaconu, Ahmed Mansouri, Department of Molecular Cell Biology, Max-Planck-Institute for Biophysical Chemistry, 37077 Göttingen, Germany.

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http://dx.doi.org/10.4252/wjsc.v6.i2.248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999782PMC
April 2014

Human stem cell models of neurodegeneration: a novel approach to study mechanisms of disease development.

Acta Neuropathol 2014 Feb 5;127(2):151-73. Epub 2013 Dec 5.

Institute of Neuropathology, University Hospital Münster, Pottkamp 2, 48149, Münster, Germany,

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http://dx.doi.org/10.1007/s00401-013-1222-6DOI Listing
February 2014

Puma, but not noxa is essential for oligodendroglial cell death.

Glia 2013 Oct 6;61(10):1712-23. Epub 2013 Aug 6.

Institute of Neuropathology, University Hospital Münster, Pottkamp 2, 48149 Münster, Germany.

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http://dx.doi.org/10.1002/glia.22552DOI Listing
October 2013

Full-length and fragmented netrin-1 in multiple sclerosis plaques are inhibitors of oligodendrocyte precursor cell migration.

Am J Pathol 2013 Sep 4;183(3):673-80. Epub 2013 Jul 4.

Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.ajpath.2013.06.004DOI Listing
September 2013

Oligodendrocyte progenitor cell susceptibility to injury in multiple sclerosis.

Am J Pathol 2013 Aug 5;183(2):516-25. Epub 2013 Jun 5.

Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.ajpath.2013.04.016DOI Listing
August 2013

Relapsing-remitting and primary progressive MS have the same cause(s)--the neuropathologist's view: 2.

Authors:
Tanja Kuhlmann

Mult Scler 2013 Mar;19(3):268-9

Institute of Neuropathology, University Hospital Münster, Germany.

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http://dx.doi.org/10.1177/1352458513476563DOI Listing
March 2013

Primary progressive multiple sclerosis: part of the MS disease spectrum or separate disease entity?

Acta Neuropathol 2012 May 11;123(5):627-38. Epub 2012 Feb 11.

Neuroimmunology Unit, Montreal Neurological Institute, McGill University, Montreal, QC, Canada.

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http://dx.doi.org/10.1007/s00401-012-0953-0DOI Listing
May 2012

Multiple sclerosis - remyelination failure as a cause of disease progression.

Histol Histopathol 2012 03;27(3):277-87

Institute of Neuropathology, University Hospital Münster, Münster, Germany.

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http://www.hh.um.es/Abstracts/Vol_27/27_3/27_3_277.htm
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http://dx.doi.org/10.14670/HH-27.277DOI Listing
March 2012

XIAP protects oligodendrocytes against cell death in vitro but has no functional role in toxic demyelination.

Glia 2012 Feb 7;60(2):271-80. Epub 2011 Nov 7.

Institute of Neuropathology, University Hospital Münster, Domagkstr. 19, Münster, Germany.

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http://dx.doi.org/10.1002/glia.21261DOI Listing
February 2012

Intramedullary spinal cord metastasis and multiple brain metastases from urothelial carcinoma.

J Clin Neurosci 2011 Oct 20;18(10):1405-7. Epub 2011 Jul 20.

Department of Neuroanatomy and Molecular Brain Research, Ruhr-University Bochum, Universitätsstraße 150, 44780 Bochum, Germany.

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http://dx.doi.org/10.1016/j.jocn.2011.01.039DOI Listing
October 2011

Cells of the oligodendroglial lineage, myelination, and remyelination.

Biochim Biophys Acta 2011 Feb 29;1812(2):184-93. Epub 2010 Sep 29.

Center for Regenerative Medicine, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, EH16 4TJ, UK.

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http://dx.doi.org/10.1016/j.bbadis.2010.09.010DOI Listing
February 2011

Reduced Treg frequency in LFA-1-deficient mice allows enhanced T effector differentiation and pathology in EAE.

Eur J Immunol 2010 Dec 11;40(12):3403-12. Epub 2010 Nov 11.

Robert Koch Institute, Berlin, Germany.

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http://dx.doi.org/10.1002/eji.201040576DOI Listing
December 2010

Deficiency of XIAP leads to sensitization for Chlamydophila pneumoniae pulmonary infection and dysregulation of innate immune response in mice.

J Biol Chem 2010 Jun 28;285(26):20291-302. Epub 2010 Apr 28.

Department of Molecular Biology, Max-Planck-Institute for Infection Biology, Charitéplatz 1, D-10117 Berlin, Germany.

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http://dx.doi.org/10.1074/jbc.M109.096297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888442PMC
June 2010

In toxic demyelination oligodendroglial cell death occurs early and is FAS independent.

Neurobiol Dis 2010 Feb 22;37(2):362-9. Epub 2009 Oct 22.

Institute of Neuropathology, University Hospital Münster, Münster, Germany.

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http://dx.doi.org/10.1016/j.nbd.2009.10.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127175PMC
February 2010

Statin therapy inhibits remyelination in the central nervous system.

Am J Pathol 2009 May 6;174(5):1880-90. Epub 2009 Apr 6.

Neuroimmunology Unit, the Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.2353/ajpath.2009.080947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671276PMC
May 2009

Nogo-a expression in glial CNS tumors: a tool to differentiate between oligodendrogliomas and other gliomas?

Am J Surg Pathol 2008 Oct;32(10):1444-53

Institute of Neuropathology, University Hospital Münster, Münster, Germany.

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http://dx.doi.org/10.1097/PAS.0b013e31817ce978DOI Listing
October 2008

Diagnosis of inflammatory demyelination in biopsy specimens: a practical approach.

Acta Neuropathol 2008 Mar 4;115(3):275-87. Epub 2008 Jan 4.

Department of Neuropathology, University Medical Centre Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Germany.

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http://dx.doi.org/10.1007/s00401-007-0320-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2668559PMC
March 2008

Contrasting potential of nitric oxide and peroxynitrite to mediate oligodendrocyte injury in multiple sclerosis.

Glia 2007 Jul;55(9):926-34

Neuroimmunology Unit, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.

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http://doi.wiley.com/10.1002/glia.20514
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http://dx.doi.org/10.1002/glia.20514DOI Listing
July 2007

Oligodendrocyte injury in multiple sclerosis: a role for p53.

J Neurochem 2003 May;85(3):635-44

Neuroimmunology Unit, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1046/j.1471-4159.2003.01674.xDOI Listing
May 2003

Remyelination in multiple sclerosis.

J Neurol Sci 2003 Feb;206(2):181-5

Institut für Neuropathologie, Charité, Campus Virchow-Klinikum, Humboldt-Universität, Augustenburger Platz 1, 13353, Berlin, Germany.

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http://dx.doi.org/10.1016/s0022-510x(02)00191-0DOI Listing
February 2003

Effects of intravenous immunoglobulins on T cell and oligodendrocyte apoptosis in high-dose antigen therapy in experimental autoimmune encephalomyelitis.

Acta Neuropathol 2002 Oct 23;104(4):385-90. Epub 2002 May 23.

Department of Neurology, Neuroimmunology Branch and Clinical Research Group for Multiple Sclerosis, Julius-Maximilians Universität, Josef-Schneider-Strasse 11, 97080 Würzburg, Germany.

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http://link.springer.de/link/service/journals/00401/contents
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http://dx.doi.org/10.1007/s00401-002-0568-yDOI Listing
October 2002

Acute axonal damage in multiple sclerosis is most extensive in early disease stages and decreases over time.

Brain 2002 Oct;125(Pt 10):2202-12

Department of Neuropathology, Charité, Humboldt-Universität, Campus Virchow-Klinikum, Augustenburger Platz 1, D-13353 Berlin, Germany.

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http://dx.doi.org/10.1093/brain/awf235DOI Listing
October 2002