Publications by authors named "Tanja Holopainen"

25Publications

Treating cachexia using soluble ACVR2B improves survival, alters mTOR localization, and attenuates liver and spleen responses.

J Cachexia Sarcopenia Muscle 2018 06 2;9(3):514-529. Epub 2018 May 2.

Neuromuscular Research Center, Biology of Physical Activity, Faculty of Sport and Health Sciences, University of Jyväskylä, Rautpohjankatu 8, Jyväskylä, 40014, Finland.

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http://dx.doi.org/10.1002/jcsm.12310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989872PMC
June 2018

Elevated VEGF-D Modulates Tumor Inflammation and Reduces the Growth of Carcinogen-Induced Skin Tumors.

Neoplasia 2016 07;18(7):436-46

Oulu Center for Cell-Matrix Research, Biocenter Oulu and Faculty of Biochemistry and Molecular Medicine, FIN-90014, University of Oulu, Oulu, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2016.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4954931PMC
July 2016

Endothelial Bmx tyrosine kinase activity is essential for myocardial hypertrophy and remodeling.

Proc Natl Acad Sci U S A 2015 Oct 1;112(42):13063-8. Epub 2015 Oct 1.

Wihuri Research Institute and Translational Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, FI-00290 Helsinki, Finland;

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http://dx.doi.org/10.1073/pnas.1517810112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620883PMC
October 2015

Assessment of tumour viability in human lung cancer xenografts with texture-based image analysis.

J Clin Pathol 2015 Aug 28;68(8):614-21. Epub 2015 May 28.

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland Department of Public Health Sciences, Global Health/IHCAR, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1136/jclinpath-2015-202888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518739PMC
August 2015

MMP16 Mediates a Proteolytic Switch to Promote Cell-Cell Adhesion, Collagen Alignment, and Lymphatic Invasion in Melanoma.

Cancer Res 2015 May 25;75(10):2083-94. Epub 2015 Mar 25.

Research Programs Unit, Genome-Scale Biology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. Finnish Cancer Institute, Helsinki, Finland.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-1923DOI Listing
May 2015

Prox1 promotes expansion of the colorectal cancer stem cell population to fuel tumor growth and ischemia resistance.

Cell Rep 2014 Sep 18;8(6):1943-1956. Epub 2014 Sep 18.

Translational Cancer Biology Program, University of Helsinki, Biomedicum Helsinki, 00014 Helsinki, Finland; Wihuri Research Institute, Biomedicum Helsinki, 00014 Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.08.034DOI Listing
September 2014

CCBE1 enhances lymphangiogenesis via A disintegrin and metalloprotease with thrombospondin motifs-3-mediated vascular endothelial growth factor-C activation.

Circulation 2014 May 19;129(19):1962-71. Epub 2014 Feb 19.

Wihuri Research Institute (M.J., A.A., V.-M.L., R.K., K.A.), Translational Cancer Biology Program (M.J., S.K.J., D.T., A.A., T.H., K.A.), and Department of Biomedicine (M.J.), Biomedicum Helsinki, University of Helsinki, Helsinki, Finland; Biotechnology Programme, Spanish National Cancer Research Centre, Madrid, Spain (S.O.); Hubrecht Institute, Utrecht, The Netherlands (T.K.); and Helsinki University Central Hospital, Helsinki, Finland (K.A.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.113.002779DOI Listing
May 2014

The basis for the distinct biological activities of vascular endothelial growth factor receptor-1 ligands.

Sci Signal 2013 Jul 2;6(282):ra52. Epub 2013 Jul 2.

Translational Cancer Biology Program, Biomedicum Helsinki and Helsinki University Central Hospital, University of Helsinki, FIN-00014 Helsinki, Finland.

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http://dx.doi.org/10.1126/scisignal.2003905DOI Listing
July 2013

Deletion of the endothelial Bmx tyrosine kinase decreases tumor angiogenesis and growth.

Cancer Res 2012 Jul 16;72(14):3512-21. Epub 2012 May 16.

Molecular/Cancer Biology Program, Institute for Molecular Medicine Finland and Helsinki University Central Hospital, Research Programs Unit, Biomedicum Helsinki, Finland.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-1070DOI Listing
July 2012

Notch restricts lymphatic vessel sprouting induced by vascular endothelial growth factor.

Blood 2011 Jul 12;118(4):1154-62. Epub 2011 May 12.

Molecular/Cancer Biology Laboratory, Research Programs Unit, Institute for Molecular Medicine Finland and Helsinki University Central Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1182/blood-2010-11-317800DOI Listing
July 2011

Perspectives on lymphangiogenesis and angiogenesis in cancer.

J Surg Oncol 2011 May;103(6):484-8

Molecular/Cancer Biology Laboratory, Research Program Unit, Department of Pathology, Haartman Institute, Institute for Molecular Medicine Finland, Helsinki University Central Hospital, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1002/jso.21808DOI Listing
May 2011

Photodynamic ablation of lymphatic vessels and intralymphatic cancer cells prevents metastasis.

Sci Transl Med 2011 Feb;3(69):69ra11

Molecular/Cancer Biology Laboratory, Faculty of Medicine Research Programs, Haartman Institute, Institute for Molecular Medicine Finland and Helsinki University Central Hospital, Biomedicum Helsinki, POB 63 (Haartmaninkatu 8), University of Helsinki, 00014 Helsinki, Finland.

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http://dx.doi.org/10.1126/scitranslmed.3001699DOI Listing
February 2011

Effective suppression of vascular network formation by combination of antibodies blocking VEGFR ligand binding and receptor dimerization.

Cancer Cell 2010 Dec 2;18(6):630-40. Epub 2010 Dec 2.

Institute for Molecular Medicine Finland, Department of Pathology, Haartman Institute, Helsinki University Central Hospital, University of Helsinki, Finland.

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http://dx.doi.org/10.1016/j.ccr.2010.11.001DOI Listing
December 2010

Vascular endothelial growth factor-B acts as a coronary growth factor in transgenic rats without inducing angiogenesis, vascular leak, or inflammation.

Circulation 2010 Oct 11;122(17):1725-33. Epub 2010 Oct 11.

Molecular/Cancer Biology Laboratory and Institute for Molecular Medicine Finland, Biomedicum Helsinki, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.110.957332DOI Listing
October 2010

Angiopoietin-1 overexpression modulates vascular endothelium to facilitate tumor cell dissemination and metastasis establishment.

Cancer Res 2009 Jun;69(11):4656-64

Molecular/Cancer Biology Laboratory, Biomedicum Helsinki, Department of Pathology, Haartman Institute and Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-08-4654DOI Listing
June 2009

Loss of Bmx nonreceptor tyrosine kinase prevents pressure overload-induced cardiac hypertrophy.

Circ Res 2008 Dec 6;103(12):1359-62. Epub 2008 Nov 6.

Department of Anesthesiology, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1161/CIRCRESAHA.108.186577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735252PMC
December 2008

The tyrosine kinase inhibitor cediranib blocks ligand-induced vascular endothelial growth factor receptor-3 activity and lymphangiogenesis.

Cancer Res 2008 Jun;68(12):4754-62

Molecular/Cancer Biology Laboratory, Biomedicum Helsinki and Ludwig Institute for Cancer Research, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-5809DOI Listing
June 2008

Therapeutic differentiation and maturation of lymphatic vessels after lymph node dissection and transplantation.

Nat Med 2007 Dec 2;13(12):1458-66. Epub 2007 Dec 2.

Molecular/Cancer Biology Laboratory, Haartman Institute and Ludwig Institute for Cancer Research, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), 00014 University of Helsinki, Finland.

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http://www.nature.com/articles/nm1689
Publisher Site
http://dx.doi.org/10.1038/nm1689DOI Listing
December 2007

Vascular endothelial growth factor receptor 3 is involved in tumor angiogenesis and growth.

Cancer Res 2007 Jan;67(2):593-9

Molecular/Cancer Biology Research Program and Ludwig Institute for Cancer Research, Biomedicum Helsinki, Haartman Institute and Helsinki University Central Hospital, University of Helsinki, Finland.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-3567DOI Listing
January 2007

Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels.

Cancer Res 2005 Jun;65(11):4739-46

Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki and Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-4576DOI Listing
June 2005