Publications by authors named "Tanja Gonska"

86Publications

Emerging preclinical modulators developed for F508del-CFTR have the potential to be effective for ORKAMBI resistant processing mutants.

J Cyst Fibros 2020 Jul 30. Epub 2020 Jul 30.

Programme in Molecular Medicine, Hospital for Sick Children, Toronto, Canada; Department of Physiology, University of Toronto, Toronto, Canada; Department of Biochemistry, University of Toronto, Toronto, Canada. Electronic address:

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July 2020

DIGEST: Developing innovative gastroenterology specialty training.

J Cyst Fibros 2020 Jul 28. Epub 2020 Jul 28.

Department of Medicine, Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.

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July 2020

An Infant with Acute Onset of Nonbilious Emesis.

Gastroenterology 2021 Jan 4;160(1):e9-e10. Epub 2020 Jun 4.

Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

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January 2021

Clinical Characteristics and Long-term Outcomes of Children With Fibrosing Pancreatitis.

J Pediatr Gastroenterol Nutr 2020 06;70(6):801-807

Division of Gastroenterology, Hepatology and Nutrition, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

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June 2020

The CFTR Mutation c.3453G > C (D1152H) Confers an Anion Selectivity Defect in Primary Airway Tissue that Can Be Rescued by Ivacaftor.

J Pers Med 2020 May 13;10(2). Epub 2020 May 13.

Programme in Translational Medicine, Research Institute, Hospital for Sick Children, 555 University Avenue, room 8415, Toronto, ON M5G 8X4, Canada.

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May 2020

Functional rescue of c.3846G>A (W1282X) in patient-derived nasal cultures achieved by inhibition of nonsense mediated decay and protein modulators with complementary mechanisms of action.

J Cyst Fibros 2020 Sep 9;19(5):717-727. Epub 2019 Dec 9.

Programme in Molecular Medicine, Hospital for Sick Children Research Institute, Toronto, Canada; Department of Physiology, University of Toronto, Toronto, Canada; Department of Biochemistry, University of Toronto, Toronto, Canada. Electronic address:

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September 2020

Long-term effect of CFTR modulator therapy on airway nitric oxide.

Eur Respir J 2020 01 9;55(1). Epub 2020 Jan 9.

Division of Respiratory Medicine, Dept of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

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January 2020

ORKAMBI-Mediated Rescue of Mucociliary Clearance in Cystic Fibrosis Primary Respiratory Cultures Is Enhanced by Arginine Uptake, Arginase Inhibition, and Promotion of Nitric Oxide Signaling to the Cystic Fibrosis Transmembrane Conductance Regulator Channel.

Mol Pharmacol 2019 10 19;96(4):515-525. Epub 2019 Aug 19.

Programmes in Translational Medicine (Y.-S.W., C.B., W.I., H.O., T.G., T.J.M.) and Molecular Medicine (Y.-S.W., J.J., S.A., A.L., O.L., S.X., L.W., C.E.B.), Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada; and Departments of Laboratory Medicine and Pathobiology (T.J.M.), Biochemistry (C.E.B.), Physiology (Y.-S.W., S.A., O.L., S.X., C.E.B.), and Paediatrics (T.G., T.J.M.), University of Toronto, Toronto, Ontario, Canada

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October 2019

Using registries for research in CF. How can we be sure about the outputs?

J Cyst Fibros 2019 05 11;18(3):309-310. Epub 2019 Apr 11.

Department of Pediatrics, University of Toronto and Research Institute, Hospital for Sick Children, Toronto, Canada. Electronic address:

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May 2019

Impact of CFTR modulation with Ivacaftor on Gut Microbiota and Intestinal Inflammation.

Sci Rep 2018 12 13;8(1):17834. Epub 2018 Dec 13.

Department of Paediatrics, Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, Toronto, Ontario, Canada.

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December 2018

Phenotypic spectrum of patients with cystic fibrosis and cystic fibrosis-related disease carrying p.Arg117His.

J Cyst Fibros 2019 03 29;18(2):265-270. Epub 2018 Sep 29.

Physiology and Experimental Medicine, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada; Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada. Electronic address:

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March 2019

Hydrogen peroxide promotes gastric motility in the newborn rat.

Pediatr Res 2018 11 24;84(5):751-756. Epub 2018 Aug 24.

Translational Medicine Program, Hospital for Sick Children Research Institute; Department of Paediatrics and Physiology, University of Toronto, Toronto, Ontario, Canada.

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November 2018

Genetic predisposition in pancreatitis.

Authors:
Tanja Gonska

Curr Opin Pediatr 2018 10;30(5):660-664

Division of Pediatric Gastroenterology, Hepatology and Nutrition, University of Toronto, and the Program of Translational Medicine, the Hospital for Sick Children, Toronto, Ontario, Canada.

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October 2018

The CF Canada-Sick Kids Program in individual CF therapy: A resource for the advancement of personalized medicine in CF.

J Cyst Fibros 2019 01 10;18(1):35-43. Epub 2018 Oct 10.

Molecular Structure and Function, Hospital for Sick Children, Toronto, Canada; Department of Physiology, University of Toronto, Toronto, Canada; Department of Biochemistry, University of Toronto, Toronto, Canada. Electronic address:

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January 2019

Serial Balloon Dilation to Relieve Gastric Outlet Obstruction Induced by the Ingestion of Toilet Cleaner.

J Pediatr Gastroenterol Nutr 2018 02;66(2):e56

Department of Pediatric Gastroenterology, Hepatology and Nutrition.

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February 2018

Bacterial overgrowth, dysbiosis, inflammation, and dysmotility in the Cystic Fibrosis intestine.

J Cyst Fibros 2017 Nov;16 Suppl 2:S14-S23

Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada; Translational Medicine, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada.

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November 2017

The Sweat Metabolome of Screen-Positive Cystic Fibrosis Infants: Revealing Mechanisms beyond Impaired Chloride Transport.

ACS Cent Sci 2017 Aug 31;3(8):904-913. Epub 2017 Jul 31.

Department of Chemistry and Chemical Biology, McMaster University, Hamilton, Ontario L8S 4L8, Canada.

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August 2017

Therapeutic Endoscopic Retrograde Cholangiopancreatography in Pediatric Patients With Acute Recurrent and Chronic Pancreatitis: Data From the INSPPIRE (INternational Study group of Pediatric Pancreatitis: In search for a cuRE) Study.

Pancreas 2017 07;46(6):764-769

From the *Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX; and †Section of Pediatric Gastroenterology and Nutrition, Baylor College of Medicine, Houston, TX; ‡Department of Pediatrics, Seattle Children's Hospital, Seattle, WA; §Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; ∥Department of Medicine and Pediatrics, Cedars-Sinai Medical Center, Los Angeles, CA; ¶Department of Pediatrics, University of Minnesota, University of Minnesota Masonic Children's Hospital, Minneapolis, MN; #Department of Paediatrics, University of Toronto, and Research Institute, The Hospital for Sick Children, Toronto, Canada; **Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA; ††Department of Pediatrics, The Ohio State University and Nationwide Children's Hospital, Columbus, OH; ‡‡Department of Pediatrics, University of California at San Francisco, San Francisco, CA; §§Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA; ∥∥Department of Pediatrics, Rady Children's Hospital, San Diego, CA; ¶¶Department of Pediatrics, Montreal Children's Hospital, McGill University, Montreal, Canada; ##Faculty of Medicine, School of Women's and Children's Health, University of New South Wales and Sydney Children's Hospital Randwick, Sydney, Australia; ***Division of Pediatric Gastroenterology, University of Utah, Salt Lake City, UT; †††Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI; ‡‡‡Department of Pediatric Gastroenterology, Hadassah Hebrew University Hospital, Jerusalem, Israel; and §§§Department of Biostatistics, University of Iowa College of Public Health; and ∥∥∥Stead Family Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA.

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July 2017

Psychosocial Response to Uncertain Newborn Screening Results for Cystic Fibrosis.

J Pediatr 2017 05 6;184:165-171.e1. Epub 2017 Mar 6.

Child Health Evaluative Sciences, The Hospital for Sick Children Research Institute, Toronto, Canada; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada; Department of Pediatrics, Faculty of Medicine, University of Toronto, Toronto, Canada; Department of Pediatrics, The Hospital for Sick Children, Toronto, Canada; Health System Planning & Evaluation Research Program, Institute for Clinical Evaluative Sciences, Toronto, Canada.

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May 2017

Cystic Fibrosis Transmembrane Conductance Regulator-Related Metabolic Syndrome and Cystic Fibrosis Screen Positive, Inconclusive Diagnosis.

J Pediatr 2017 02;181S:S45-S51.e1

Department for Women's and Children's Health, University of Liverpool, Institute in the Park, Alder Hey Children's Hospital, Liverpool, United Kingdom.

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February 2017

Causal Evaluation of Acute Recurrent and Chronic Pancreatitis in Children: Consensus From the INSPPIRE Group.

J Pediatr Gastroenterol Nutr 2017 01;64(1):95-103

*Nationwide Children's Hospital and The Ohio State University, Columbus †University of California at San Francisco, San Francisco ‡Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA §University of Utah, Salt Lake City ||Medical College of Wisconsin, Milwaukee ¶Hadassah-Hebrew University Medical Center, Jerusalem, Israel #University of Texas, Southwestern Medical School, Dallas **Baylor College of Medicine, Houston, TX ††Harvard Medical School, Boston, MA ‡‡Seattle Children's Hospital, Seattle, WA §§Hospital for Sick Children, Toronto, ON ||||Montreal Children's Hospital, McGill University, Montreal, QC, Canada ¶¶University of New South Wales and Sydney Children's Hospital Randwick, Sydney, Australia ##University of Minnesota, Masonic Children's Hospital, Minneapolis ***University of Iowa, Children's Hospital, Iowa City.

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January 2017

Parent Experience With False-Positive Newborn Screening Results for Cystic Fibrosis.

Pediatrics 2016 09 2;138(3). Epub 2016 Aug 2.

Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, Canada; Institute of Health Policy, Management and Evaluation, Departments of Pediatrics and Pediatric Medicine, and Institute for Clinical Evaluative Sciences, Toronto, Canada.

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September 2016

Endoplasmic reticulum stress is involved in the colonic epithelium damage induced by maternal separation.

J Pediatr Surg 2016 Jun 2;51(6):1001-4. Epub 2016 Mar 2.

Division of General and Thoracic Surgery, Physiology and Experimental Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada. Electronic address:

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June 2016

Lung clearance index response in patients with CF with class III CFTR mutations.

Thorax 2016 May 4;71(5):476-7. Epub 2016 Mar 4.

Division of Respiratory Medicine, Department of Pediatrics, Toronto, Ontario, Canada Physiology & Experimental Medicine, The Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada Department of Pediatrics, University of Toronto, Ontario, Canada.

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May 2016

Testing gene therapy vectors in human primary nasal epithelial cultures.

Mol Ther Methods Clin Dev 2015 9;2:15034. Epub 2015 Sep 9.

Programme in Physiology & Experimental Medicine, Research Institute, Hospital for Sick Children, Toronto, Onatrio, Canada; Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

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January 2016

Direct Costs of Acute Recurrent and Chronic Pancreatitis in Children in the INSPPIRE Registry.

J Pediatr Gastroenterol Nutr 2016 Mar;62(3):443-9

*University of California, San Francisco †University of Minnesota Masonic Children's Hospital, Minneapolis ‡Baylor College of Medicine, Houston, TX §University of Texas Southwestern Medical School, Dallas ||Hospital for Sick Children, Toronto, ON, Canada ¶Harvard Medical School, Boston, MA #Nationwide Children's Hospital, Columbus, OH **Seattle Children's Hospital, Seattle, WA ††Children's Hospital of Pittsburgh, Pittsburgh, PA ‡‡Montreal Children's Hospital, McGill University, Montreal, QC, Canada §§Discipline of Paediatrics, School of Women's and Children's Health, Medicine, University of New South Wales and Sydney Children's Hospital Randwick, Sydney, Australia ||||University of Utah, Salt Lake City, UT ¶¶Medical College of Wisconsin, Milwaukee, WI ##Hadassah Hebrew University Hospital, Jerusalem, Israel ***University of Iowa Carver College of Medicine, IA.

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March 2016

The Gut Is a Key Player in Cystic Fibrosis Malnutrition.

Authors:
Tanja Gonska

J Pediatr Gastroenterol Nutr 2016 Apr;62(4):518-9

*Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Toronto †Program of Physiology and Experimental Medicine, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada.

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April 2016

Author's Response: Re: Stratifying Cystic Fibrosis Risk for Newborn Screen Infants With Equivocal Sweat Chloride Levels.

Pediatrics 2015 Nov;136(5):e1490-1

Division of Gastroenterology, Hepatology and Nutrition, Department of Paediatrics, and Physiology and Experimental Medicine, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada

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November 2015

Pancreatic Head Mass Leading to Transient Obstructive Jaundice and Diabetes Mellitus in an Adolescent.

Gastroenterology 2015 Dec 27;149(7):e9-e10. Epub 2015 Oct 27.

Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada.

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December 2015

Newborn screening for cystic fibrosis.

Expert Rev Respir Med 2015 Oct;9(5):619-31

b 2 Program of Physiology and Experimental Medicine, Research Institute, the Hospital for Sick Children, Toronto, ON, Canada.

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October 2015

Effect of ivacaftor therapy on exhaled nitric oxide in patients with cystic fibrosis.

J Cyst Fibros 2015 Nov 11;14(6):727-32. Epub 2015 Jul 11.

Division of Respiratory Medicine, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Canada; Program in Physiology and Experimental Medicine, SickKids Research Institute, The Hospital for Sick Children, University of Toronto, Toronto, Canada.

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November 2015

Early maternal separation induces alterations of colonic epithelial permeability and morphology.

Pediatr Surg Int 2014 Dec 31;30(12):1217-22. Epub 2014 Oct 31.

Department of Physiology and Experimental Medicine, The Hospital for Sick Children, Toronto, ON, Canada.

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December 2014

Nasal potential difference: Best or average result for CFTR function as diagnostic criteria for cystic fibrosis?

J Cyst Fibros 2015 May 7;14(3):310-6. Epub 2014 Oct 7.

Department of Pediatrics, Justus-Liebig-University Giessen, Giessen, Germany. Electronic address:

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May 2015

Design and implementation of INSPPIRE.

J Pediatr Gastroenterol Nutr 2014 Sep;59(3):360-4

*Montreal Children's Hospital, McGill University, Montreal, Canada †Children's Hospital of Pittsburgh, Pittsburgh, PA ‡University of Iowa Children's Hospital (UICH), Iowa City §University of Texas Southwestern Medical School, Dallas ||University of Minnesota, Amplatz Children's Hospital, Minneapolis ¶The Hospital for Sick Children and University of Toronto, Toronto, Canada #Baylor College of Medicine, Houston, TX **Beth Israel Deaconess Medical Center, Boston, MA ††Nationwide Children's Hospital (NCH), Columbus, OH ‡‡Seattle Children's Hospital, Seattle, WA §§University of California at San Francisco ||||University of New South Wales and Sydney Children's Hospital, Randwick, Australia ¶¶University of Utah, Salt Lake City ##Hadassah Hebrew University Medical Center, Jerusalem, Israel.

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September 2014

VX-809 and related corrector compounds exhibit secondary activity stabilizing active F508del-CFTR after its partial rescue to the cell surface.

Chem Biol 2014 May 10;21(5):666-78. Epub 2014 Apr 10.

Programme of Molecular Structure and Function, Research Institute, Hospital for Sick Children, The Peter Gilgan Centre for Research and Learning, Toronto, ON M5G 1X8, Canada. Electronic address:

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May 2014

An infant with vomiting, diarrhea, and failure to thrive. Chylomicron retention disease.

Gastroenterology 2014 Apr 19;146(4):912, 1137-8. Epub 2014 Feb 19.

Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada.

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April 2014

Genetic, cell biological, and clinical interrogation of the CFTR mutation c.3700 A>G (p.Ile1234Val) informs strategies for future medical intervention.

Genet Med 2014 Aug 20;16(8):625-32. Epub 2014 Feb 20.

1] Programme in Molecular Structure and Function, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada [2] Department of Biochemistry, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada [3] Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

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August 2014

The intestinal epithelial insulin-like growth factor-1 receptor links glucagon-like peptide-2 action to gut barrier function.

Endocrinology 2014 Feb 21;155(2):370-9. Epub 2013 Nov 21.

Departments of Physiology (C.X.D., W.Z., C.S., K.J.R., P.L.B.), Pediatrics (T.G.), and Medicine (P.L.B.), University of Toronto, Toronto, Ontario M5S 1A8 Canada; Department of Paediatric Laboratory Medicine (C.A.), and Physiology and Experimental Medicine, Research Institute (T.G.), The Hospital for Sick Children, Toronto M5G 1X8, Canada; Centre National de la Recherche Scientifique (S.R.), Institut Curie, Paris, 75248 France; and Inserm (M.H.), Hôpital St-Antoine, Paris, 75005 France.

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February 2014

Severely elevated transaminases in an adolescent male with anorexia nervosa.

Int J Eat Disord 2013 Nov 23;46(7):751-4. Epub 2013 Jul 23.

Department of General Paediatrics, The Hospital for Sick Children, University of Toronto, Ontario, Canada.

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November 2013

β-adrenergic sweat secretion as a diagnostic test for cystic fibrosis.

Am J Respir Crit Care Med 2012 Oct 2;186(8):732-9. Epub 2012 Aug 2.

Department of Pediatrics, University of California-San Diego, La Jolla, CA, USA.

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October 2012

Comparing the American and European diagnostic guidelines for cystic fibrosis: same disease, different language?

Thorax 2012 Jul 15;67(7):618-24. Epub 2012 Apr 15.

School of Women's and Children's Health, Faculty of Medicine, University of New South Wales and Sydney Children's Hospital, Randwick, Sydney, Australia.

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July 2012

Role of cystic fibrosis transmembrane conductance regulator in patients with chronic sinopulmonary disease.

Chest 2012 Oct;142(4):996-1004

Department of Medicine, University of Toronto, Toronto, ON, Canada; Division of Respirology and Keenan Research Centre of Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada. Electronic address:

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October 2012

Early in vivo testing to assess new therapeutic interventions in CF patients.

Authors:
Tanja Gonska

Curr Pharm Des 2012 ;18(5):663-73

Division of Gastroenterology, Hepatology and Nutrition, Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G1X8, Canada.

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June 2012

Type of CFTR mutation determines risk of pancreatitis in patients with cystic fibrosis.

Gastroenterology 2011 Jan 9;140(1):153-61. Epub 2010 Nov 9.

Physiology and Experimental Medicine, The Research Institute, Department of Pediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada.

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January 2011

Severe ulcerative colitis after rituximab therapy.

Pediatrics 2010 Jul 21;126(1):e243-6. Epub 2010 Jun 21.

Division of Rheumatology, Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

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July 2010

Genetic testing in pancreatitis.

Gastroenterology 2010 Jun 20;138(7):2202-6, 2206.e1. Epub 2010 Apr 20.

Research Institute and Division of Gastroenterology, Hepatology and Nutrition Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada.

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June 2010

Assessment of CFTR function in rectal biopsies for the diagnosis of cystic fibrosis.

J Cyst Fibros 2004 Aug;3 Suppl 2:165-9

Department of Pediatrics III, Pediatric Pulmonology and Infectious Diseases, University of Heidelberg, lm Neuenheimer Feld 153, Heidelberg D-69120, Germany.

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August 2004

Activation of ion secretion via proteinase-activated receptor-2 in human colon.

Am J Physiol Gastrointest Liver Physiol 2002 Feb;282(2):G200-10

Universitäts-Kinderklinik, Albert-Ludwigs-Universität Freiburg, 79106 Freiburg, Germany.

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February 2002