Publications by authors named "Tanios Bekaii-Saab"

100Publications

Targeting of the Hedgehog/GLI and mTOR pathways in advanced pancreatic cancer, a phase 1 trial of Vismodegib and Sirolimus combination.

Pancreatology 2020 Sep 14;20(6):1115-1122. Epub 2020 Jul 14.

Schulze Center for Novel Therapeutics, Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, MN, USA; Department of Medical Oncology, Department of Oncology, Mayo Clinic, 200 1st St SW, Rochester, MN, 55902, USA. Electronic address:

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http://dx.doi.org/10.1016/j.pan.2020.06.015DOI Listing
September 2020

Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study.

Lancet 2020 06 28;395(10241):1907-1918. Epub 2020 May 28.

Vanderbilt-Ingram Cancer Center at Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(20)31187-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255743PMC
June 2020

The Role of Maintenance Therapy in Metastatic Colorectal Cancer-Reply.

JAMA Oncol 2020 Jun;6(6):937-938

Division of Hematology/Oncology, Mayo Clinic, Phoenix, Arizona.

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http://dx.doi.org/10.1001/jamaoncol.2020.0583DOI Listing
June 2020

Improvements in Clinical Outcomes for -Mutant Metastatic Colorectal Cancer.

Clin Cancer Res 2020 Sep 6;26(17):4435-4441. Epub 2020 Apr 6.

Mayo Clinic College of Medicine and Science, Phoenix, Arizona.

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http://dx.doi.org/10.1158/1078-0432.CCR-19-3809DOI Listing
September 2020

The Role of Immune Checkpoint Inhibitors in Colorectal Adenocarcinoma.

BioDrugs 2020 Jun;34(3):349-362

Division of Hematology and Medical Oncology, Mayo Clinic Cancer Center, Mayo Clinic Hospital, 5777 E Mayo Blvd, Phoenix, AZ, 85054, USA.

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http://dx.doi.org/10.1007/s40259-020-00420-3DOI Listing
June 2020

Biliary tract cancer and genomic alterations in homologous recombinant deficiency: exploiting synthetic lethality with PARP inhibitors.

Chin Clin Oncol 2020 Feb 20;9(1). Epub 2020 Feb 20.

Mayo Clinic, Phoenix, AZ, USA.

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http://dx.doi.org/10.21037/cco.2020.02.02DOI Listing
February 2020

Sequencing beyond the second-line setting in metastatic colorectal cancer: further observations.

Clin Adv Hematol Oncol 2019 Mar;17 Suppl 7(3):16-18

Mayo Clinic Cancer Center, Mayo Clinic, Phoenix, Arizona.

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March 2019

Clinical Trial Data for Third-Line Therapy in Metastatic Colorectal Cancer.

Clin Adv Hematol Oncol 2019 Mar;17 Suppl 7(3):5-13

Mayo Clinic Cancer Center, Mayo Clinic, Phoenix, Arizona.

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March 2019

Sequencing beyond the second-line setting in metastatic colorectal cancer.

Clin Adv Hematol Oncol 2019 Mar;17 Suppl 7(3):1-19

Mayo Clinic Cancer Center, Mayo Clinic, Phoenix, Arizona.

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March 2019

AJCC 8th edition staging system for pathologically versus clinically staged intrahepatic cholangiocarcinoma (iCCA): ready for prime time?

Chin Clin Oncol 2019 Oct 6;8(S1):S19. Epub 2019 May 6.

Department of Internal Medicine, Division of Hematology/Medical Oncology, Mayo Clinic, Phoenix, AZ, USA.

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http://dx.doi.org/10.21037/cco.2019.04.04DOI Listing
October 2019

Sister Mary Joseph Nodule in Advanced Pancreatic Adenocarcinoma Identified on F-FDG PET/MRI.

J Nucl Med Technol 2019 Dec 24;47(4):341-342. Epub 2019 Apr 24.

Department of Radiology, Mayo Clinic, Scottsdale, Arizona; and.

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http://dx.doi.org/10.2967/jnmt.119.225961DOI Listing
December 2019

Watch and Wait in Rectal Cancer: Who's In and Who's Out?

J Oncol Pract 2019 03;15(3):133-134

1 Mayo Clinic Arizona, Phoenix, AZ.

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http://dx.doi.org/10.1200/JOP.19.00071DOI Listing
March 2019

Therapeutic Targeting Strategies of Cancer Stem Cells in Gastrointestinal Malignancies.

Biomedicines 2019 Mar 10;7(1). Epub 2019 Mar 10.

Mayo Clinic Cancer Center, Mayo Clinic, Phoenix, AZ 85054, USA.

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https://www.mdpi.com/2227-9059/7/1/17
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http://dx.doi.org/10.3390/biomedicines7010017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466109PMC
March 2019

How I treat metastatic colorectal cancer.

Clin Adv Hematol Oncol 2018 Sep;16 Suppl 18(9):2-6

Mayo Clinic College of Medicine and Science, Mayo Clinic Cancer Center, Phoenix, Arizona.

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September 2018

New guideline-sanctioned and emerging interventions for pancreatic cancer.

Clin Adv Hematol Oncol 2018 Sep;16 Suppl 17(9):7-9

Mayo Clinic College of Medicine and Science, Mayo Clinic Cancer Center, Phoenix, Arizona.

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September 2018

A treatment landscape in evolution: new strategies, guidelines, and therapeutic advances for metastatic pancreatic adenocarcinoma.

Clin Adv Hematol Oncol 2018 Sep;16 Suppl 17(9):5-7

Mayo Clinic College of Medicine and Science, Mayo Clinic Cancer Center, Phoenix, Arizona.

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September 2018

Therapeutic advances in metastatic pancreatic adenocarcinoma and related cancers: focus on evidence-based and sequenced approaches to survival extension in metastatic pancreatic adenocarcinoma.

Clin Adv Hematol Oncol 2018 Sep;16 Suppl 17(9):1-16

Center for Carcinoid and Neuroendocrine Tumors, Mount Sinai School of Medicine, New York, New York.

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September 2018

Third- or Later-line Therapy for Metastatic Colorectal Cancer: Reviewing Best Practice.

Clin Colorectal Cancer 2019 03 16;18(1):e117-e129. Epub 2018 Nov 16.

Department of Medicine I, Comprehensive Cancer Center Vienna, Medical University Vienna, Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.clcc.2018.11.002DOI Listing
March 2019

A closer look at regorafenib.

Clin Adv Hematol Oncol 2018 Oct;16(10):667-669

Mayo Clinic Cancer Center, Phoenix, Arizona.

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October 2018

Clinical update on K-Ras targeted therapy in gastrointestinal cancers.

Crit Rev Oncol Hematol 2018 Oct 2;130:78-91. Epub 2018 Aug 2.

Mayo Clinic Cancer Center, Mayo Clinic, Phoenix, Arizona, USA.

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http://dx.doi.org/10.1016/j.critrevonc.2018.07.011DOI Listing
October 2018

Novel immunotherapy strategies for hepatobiliary cancers.

Immunotherapy 2018 09;10(12):1077-1091

Department of Medicine, Division of Hematology & Oncology, Mayo Clinic, Scottsdale, AZ 85259, USA.

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http://dx.doi.org/10.2217/imt-2018-0024DOI Listing
September 2018

Antiangiogenic Therapy in Colorectal Cancer.

Cancer J 2018 Jul/Aug;24(4):165-170

Department of Hematology and Oncology, Mayo Clinic Arizona, Phoenix, AZ.

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http://dx.doi.org/10.1097/PPO.0000000000000328DOI Listing
June 2019

Emerging Therapies and Future Directions in Targeting the Tumor Stroma and Immune System in the Treatment of Pancreatic Adenocarcinoma.

Cancers (Basel) 2018 Jun 11;10(6). Epub 2018 Jun 11.

Department of Hematology/Medical Oncology, Mayo Clinic Cancer Center, 5777 E. Mayo Blvd, Phoenix, AZ 85054, USA.

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http://dx.doi.org/10.3390/cancers10060193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025083PMC
June 2018

Phase 1b investigation of the MEK inhibitor binimetinib in patients with advanced or metastatic biliary tract cancer.

Invest New Drugs 2018 12 22;36(6):1037-1043. Epub 2018 May 22.

Department of Medicine, Mayo Clinic, 5881 E Mayo Blvd, Phoenix, AZ, 85054, USA.

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http://dx.doi.org/10.1007/s10637-018-0600-2DOI Listing
December 2018

Highlights in pancreatic cancer from the 2018 American Society of Clinical Oncology Gastrointestinal Cancers Symposium: commentary.

Clin Adv Hematol Oncol 2018 Mar;16 Suppl 7(3):16-18

Mayo Clinic College of Medicine and Science, Mayo Clinic Cancer Center, Phoenix, Arizona.

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March 2018

Clinical Trials and Progress in Metastatic Colon Cancer.

Surg Oncol Clin N Am 2018 04;27(2):349-365

Gastrointestinal Cancer Program, Mayo Clinic Cancer Center, Mayo Clinic Arizona, 5777 East Mayo Boulevard, Phoenix, AZ 85054, USA. Electronic address:

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http://dx.doi.org/10.1016/j.soc.2017.11.008DOI Listing
April 2018

Novel targeted therapy strategies for biliary tract cancers and hepatocellular carcinoma.

Future Oncol 2018 Mar 20;14(6):553-566. Epub 2018 Feb 20.

Division of Hematology Oncology, Department of Medicine, Mayo Clinic, Scottsdale, AZ 85259, USA.

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http://dx.doi.org/10.2217/fon-2017-0451DOI Listing
March 2018

A clinical trial protocol paper discussing the BRIGHTER study.

Future Oncol 2018 Apr 3;14(10):901-906. Epub 2018 Jan 3.

Mayo Clinic Cancer Center, Mayo Clinic, Phoenix, AZ 85054, USA.

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http://dx.doi.org/10.2217/fon-2017-0406DOI Listing
April 2018

Phase II Study of BGJ398 in Patients With FGFR-Altered Advanced Cholangiocarcinoma.

J Clin Oncol 2018 01 28;36(3):276-282. Epub 2017 Nov 28.

Milind Javle and Rachna T. Shroff, The University of Texas MD Anderson Cancer Center, Houston, TX; Maeve Lowery and Ghassan K. Abou-Alfa, Memorial Sloan Kettering Cancer Center, and Weill Cornell Medical College, New York, NY; Karl Heinz Weiss and Christoph Springfeld, Universitäts Klinikum Heidelberg, Heidelberg, Germany; Mitesh J. Borad, Ramesh K. Ramanathan, and Tanios Bekaii-Saab, Mayo Clinic, Phoenix, AZ; Lipika Goyal and Andrew X. Zhu, Massachusetts General Hospital Cancer Center, Boston, MA; Saeed Sadeghi and Richard S. Finn, David Geffen School of Medicine at UCLA; Anthony El-Khoueiry, USC Norris Comprehensive Cancer Center, Keck School of Medicine, Los Angeles; Robin Kate Kelley, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA; Teresa Macarulla, Vall d'Hebron University Hospital and Vall d'Hebron Institute of Oncology, Barcelona, Spain; Ivan Borbath, Cliniques Universitaires Saint-Luc, Brussels; Eric Van Cutsem, University Hospitals Gasthuisberg and KU Leuven, Leuven, Belgium; Su Pin Choo, National Cancer Centre of Singapore, Singapore; Do-Youn Oh, Seoul National University, Seoul, South Korea; Philip A. Philip, Karmanos Cancer Institute, Detroit, MI; Li-Tzong Chen, National Institute of Cancer Research and National Cheng Kung University Hospital, Tainan; Kun-Huei Yeh, National Taiwan University Hospital Cancer Center, and Cancer Research Center, National Taiwan University College of Medicine, Taipei, Taiwan; Thanyanan Reungwetwattana, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; Kristen Ciombor, The Ohio State University Wexner Medical Center, Columbus, OH; and Anuradha Patel, Suman Sen, Dale Porter, and Randi Isaacs, Novartis Pharmaceuticals Corporation, East Hanover, NJ.

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http://dx.doi.org/10.1200/JCO.2017.75.5009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075847PMC
January 2018

Biweekly cisplatin and gemcitabine in patients with advanced biliary tract cancer.

Int J Cancer 2018 04 17;142(8):1671-1675. Epub 2017 Nov 17.

Department of Internal Medicine, Mayo Clinic, Phoenix, AZ.

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http://dx.doi.org/10.1002/ijc.31144DOI Listing
April 2018

A Comprehensive Review of Sequencing and Combination Strategies of Targeted Agents in Metastatic Colorectal Cancer.

Oncologist 2018 01 11;23(1):25-34. Epub 2017 Oct 11.

Division of Hematology and Medical Oncology, Department of Internal Medicine, Mayo Clinic Cancer Center, Phoenix, Arizona, USA

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http://dx.doi.org/10.1634/theoncologist.2017-0203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5759820PMC
January 2018

Targeting BRAF in metastatic colorectal cancer: Maximizing molecular approaches.

Cancer Treat Rev 2017 Nov 31;60:109-119. Epub 2017 Aug 31.

Mayo Clinic, 5777 E Mayo Blvd, Phoenix, AZ 85054, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ctrv.2017.08.006DOI Listing
November 2017

Predictors of Pancreatic Cancer-Associated Weight Loss and Nutritional Interventions.

Pancreas 2017 10;46(9):1152-1157

From the *Division of Gastroenterology, Hepatology, and Nutrition, †Department of Radiology, ‡Division of Surgical Oncology, §Department of Cancer Biology and Genetics, ∥Division of Biostatistics, College of Public Health, ¶Division of General Surgery, #Division of Medical Oncology, The Ohio State University Wexner Medical Center, Columbus, OH; and **Division of Medical Oncology and Hematology, Mayo Clinic, Phoenix, AZ.

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http://dx.doi.org/10.1097/MPA.0000000000000898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679236PMC
October 2017

Using Naïve Bayesian Analysis to Determine Imaging Characteristics of KRAS Mutations in Metastatic Colon Cancer.

Diagnostics (Basel) 2017 Sep 2;7(3). Epub 2017 Sep 2.

Department of Radiology, Division of Vascular & Interventional Radiology, Mayo Clinic, Phoenix, AZ 85054, USA.

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http://dx.doi.org/10.3390/diagnostics7030050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617950PMC
September 2017

Second-line treatment in patients with pancreatic ductal adenocarcinoma: A meta-analysis.

Cancer 2017 Dec 17;123(23):4680-4686. Epub 2017 Aug 17.

Mayo Clinic Cancer Center, Mayo Clinic, Phoenix, Arizona.

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http://dx.doi.org/10.1002/cncr.30927DOI Listing
December 2017

Response to Drs Von Hoff and Renschler.

Ther Adv Med Oncol 2017 Jun 30;9(6):445-446. Epub 2017 May 30.

Department of Medicine, Division of Hematology/Medical Oncology, Mayo Clinic, 5777 East Mayo Clinic Boulevard, Phoenix, AZ 85054, USA.

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http://dx.doi.org/10.1177/1758834017709238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455884PMC
June 2017

The Continued Promise and Many Disappointments of Oncolytic Virotherapy in Gastrointestinal Malignancies.

Biomedicines 2017 Mar 4;5(1). Epub 2017 Mar 4.

Division of Hematology/Medical Oncology, Mayo Clinic, 5777 E. Mayo Blvd, Phoenix, AZ 85054, USA.

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http://www.mdpi.com/2227-9059/5/1/10
Publisher Site
http://dx.doi.org/10.3390/biomedicines5010010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423495PMC
March 2017

Therapeutic options for intrahepatic cholangiocarcinoma.

Hepatobiliary Surg Nutr 2017 Apr;6(2):91-100

Hematology/Medical Oncology, Mayo Clinic, Phoenix, AZ 85054, USA.

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http://dx.doi.org/10.21037/hbsn.2016.12.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411274PMC
April 2017

Signaling pathways as therapeutic targets in biliary tract cancer.

Expert Opin Ther Targets 2017 May 17;21(5):485-498. Epub 2017 Mar 17.

b Department of Hematology and Medical Oncology , The Winship Cancer Institute of Emory University , Atlanta , GA , USA.

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http://dx.doi.org/10.1080/14728222.2017.1306055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751570PMC
May 2017

Spotlight on bevacizumab in metastatic colorectal cancer: patient selection and perspectives.

Gastrointest Cancer 2016 30;6:21-30. Epub 2016 Jun 30.

Department of Medical Oncology, Richard Solove Research Institute and James Cancer Hospital, The Ohio State University Wexner Medical Center, Columbus, OH, USA.

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http://dx.doi.org/10.2147/GICTT.S97740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300250PMC
June 2016

Identifying and targeting cancer stem cells in the treatment of gastric cancer.

Cancer 2017 04 24;123(8):1303-1312. Epub 2017 Jan 24.

Department of Hematology and Medical Oncology, Emory School of Medicine, Atlanta, Georgia.

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http://dx.doi.org/10.1002/cncr.30538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412889PMC
April 2017

Neoadjuvant Therapy for Rectal Cancer Affects Lymph Node Yield and Status Without Clear Implications on Outcome: The Case for Eliminating a Metric and Using Preoperative Staging to Guide Therapy.

J Natl Compr Canc Netw 2016 12;14(12):1528-1534

From Division of Surgical Oncology, The Ohio State University Wexner Medical Center/Arthur G. James Cancer Hospital, Columbus, Ohio; Center for Biostatistics, The Ohio State University Wexner Medical Center, Columbus, Ohio; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois; Department of Hematology/Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania; City of Hope Comprehensive Cancer Center, Duarte, California; University of Texas MD Anderson Cancer Center, Houston, Texas; Kalispell Regional Healthcare Specialists, Kalispell Regional Healthcare, Kalispell, Montana; Memorial Sloan Kettering Cancer Center, New York, New York; Dana-Farber Cancer Institute, Boston, Massachusetts; and Depaartment of Medicine, Division of Hematology/Oncology, Mayo Clinic Cancer Center, Phoenix, Arizona.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292039PMC
http://dx.doi.org/10.6004/jnccn.2016.0164DOI Listing
December 2016

Targeting integrin-linked kinase to suppress oncogenic KRAS signaling in pancreatic cancer.

Small GTPases 2018 11 9;9(6):452-456. Epub 2016 Dec 9.

a Institute of Biological Chemistry , Academia Sinica , Taipei , Taiwan.

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http://dx.doi.org/10.1080/21541248.2016.1251383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204986PMC
November 2018

Suppression of Tumor Growth and Muscle Wasting in a Transgenic Mouse Model of Pancreatic Cancer by the Novel Histone Deacetylase Inhibitor AR-42.

Neoplasia 2016 Dec 25;18(12):765-774. Epub 2016 Nov 25.

Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, 1 University Rd., Tainan 701, Taiwan; Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, 1 University Rd., Tainan 701, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2016.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126135PMC
December 2016

Competitive Funding Strategies for the Conquer Cancer Foundation of ASCO.

J Oncol Pract 2017 01 22;13(1):e62-e67. Epub 2016 Nov 22.

Mayo Clinic, Phoenix, AZ; Albert Einstein College of Medicine, Bronx, NY; American Society of Clinical Oncology, Alexandria, VA; Aurora Health Care, Milwaukee, WI; and The University of Texas MD Anderson Cancer Center, Houston, TX.

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http://dx.doi.org/10.1200/JOP.2016.014571DOI Listing
January 2017

Outcomes of definitive chemoradiation in patients with esophageal cancer.

Dis Esophagus 2017 Feb;30(2):1-7

Mayo Clinic Cancer Center, Phoenix Arizona, USA.

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http://dx.doi.org/10.1111/dote.12506DOI Listing
February 2017

Autophagy Induction Results in Enhanced Anoikis Resistance in Models of Peritoneal Disease.

Mol Cancer Res 2017 01 2;15(1):26-34. Epub 2016 Nov 2.

Department of Internal Medicine, Division of Medical Oncology, The Ohio State University, Columbus, Ohio.

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http://dx.doi.org/10.1158/1541-7786.MCR-16-0200-TDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909689PMC
January 2017

Taking aim at the genomic diversity of gastrointestinal cancers: a changing landscape.

J Gastrointest Oncol 2016 Oct;7(5):673-674

Department of Hematology and Medical Oncology, Emory University, Atlanta, GA, USA.

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http://dx.doi.org/10.21037/jgo.2016.09.09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056257PMC
October 2016

Gemcitabine-Associated Thrombotic Microangiopathy: Response to Complement Inhibition and Reinitiation of Gemcitabine.

Clin Colorectal Cancer 2016 Sep 20. Epub 2016 Sep 20.

Department of Pharmacy, The James Comprehensive Cancer Center at The Ohio State University, Columbus, OH. Electronic address:

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http://dx.doi.org/10.1016/j.clcc.2016.09.004DOI Listing
September 2016