Publications by authors named "Tangde Zhang"

4 Publications

  • Page 1 of 1

Cutis marmorata telangiectatica congenita and aberrant Mongolian spots: Type V phacomatosis pigmentovascularis or phacomatosis cesiomarmorata.

JAAD Case Rep 2016 Jan 23;2(1):28-30. Epub 2016 Jan 23.

Department of Dermatology and STD, Changping Hospital of Dongguan and Zhujiang Hospital, Guangzhou, China.

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http://dx.doi.org/10.1016/j.jdcr.2015.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4809441PMC
January 2016

The allele T of rs10852936 confers risk for early-onset psoriasis.

J Dermatol Sci 2015 Feb 20;77(2):129-31. Epub 2014 Nov 20.

Institute of Dermatology and Department of Dermatology at No.1 Hospital, Anhui Medical University, Hefei, Anhui, China; Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui, China; State Key Laboratory Incubation Base of Dermatology, Ministry of National Science and Technology & Key laboratory of Dermatology, Ministry of Education, Hefei, Anhui, China; Department of Dermatology, ZhuJiang Hospital of Southern Medical University, Guangzhou, Guangdong, China; Department of Dermatology at No.2 Hospital, Anhui Medical University, Hefei, Anhui, China; Department of Dermatology, Huashan Hospital of Fudan University, Shanghai, China. Electronic address:

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http://dx.doi.org/10.1016/j.jdermsci.2014.11.004DOI Listing
February 2015

Majocchi granuloma in a pregnant woman.

Obstet Gynecol 2014 Aug;124(2 Pt 2 Suppl 1):423-425

Departments of Dermatology, the First People's Hospital of Shunde, Foshan, and Zhujiang Hospital, Guangzhou, China.

Background: Majocchi granuloma is a cutaneous dermatophyte infection of the dermal and subcutaneous tissues characterized by chronic erythematous and indurated plaques, which are almost always the result of immunodeficiency and trauma.

Case: Disseminated dermatophyte Majocchi granuloma was diagnosed in a 19-year-old woman at 32 weeks of gestation and had no history of trauma or chronic illness. She was treated with topical antifungal medications until delivery, at which time systemic medications were started. The skin lesions resolved by the time of her 6-week postpartum visit.

Conclusion: The altered immune state of pregnancy suggests that Majocchi granuloma should occur with some regularity in pregnancy. That this case is the second one described in the literature suggests that it may be underdiagnosed. Punch biopsy should be considered for diagnosis of unusual skin lesions during pregnancy.
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http://dx.doi.org/10.1097/AOG.0000000000000302DOI Listing
August 2014

[Investigation of selective inhibition of digoxin derivative on retinoic acid-related orphan nuclear receptor γt transcription activity using molecular docking].

Nan Fang Yi Ke Da Xue Xue Bao 2014 Apr;34(4):511-8

Department of Dermatology and Venereology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.E-mail:

Objective: Psoriasis is an autoimmune-related chronic inflammatory skin disease strongly associated with the dysfunction of Th17 cells. Retinoic acid-related orphan nuclear receptor γt (RORγt) plays a critical role in the differentiation and maturation of Th17 cells and in cell-derived immunologic derangement. We conducted this study to investigate potential mechanism by which the derivative of digoxin selectively antagonizes RORγt transcriptional activity.

Method: Using molecular docking in combination with molecular electrostatic potential (MEP), we detected the interaction between the derivative of digoxin (Dhd) and ROR transcription factor (RORα,RORβ and RORγt), and the results were further confirmed by bioluminescent assay.

Result: Molecular docking demonstrated that Dhd could exclusively inhibit the conformation of RORγt; bioluminescent assay further indicated that RORγt was selectively antagonized by Dhd in a dose- and time-dependent manner.

Conclusion: Dhd can selectively suppress RORγt transcriptional activity.
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April 2014
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