Publications by authors named "Tanay Chaubal"

21 Publications

  • Page 1 of 1

Recent update on potential cytotoxicity, biocompatibility and preventive measures of biomaterials used in dentistry.

Biomater Sci 2021 May;9(9):3244-3283

Faculty, Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India.

Dental treatment is provided for a wide variety of oral health problems like dental caries, periodontal diseases, periapical infections, replacement of missing teeth and orthodontic problems. Various biomaterials, like composite resins, amalgam, glass ionomer cement, acrylic resins, metal alloys, impression materials, bone grafts, membranes, local anaesthetics, etc., are used for dental applications. The physical and chemical characteristics of these materials influence the outcome of dental treatment. It also impacts on the biological, allergic and toxic potential of biomaterials. With innovations in science and their positive results, there is also a need for awareness about the biological risks of these biomaterials. The aim of dental treatment is to have effective, yet safe, and long-lasting results for the benefit of patients. For this, it is important to have a thorough understanding of biomaterials and their effects on local and systemic health. Materials used in dentistry undergo a series of analyses before their oral applications. To the best of our knowledge, this is the first and original review that discusses the reasons for and studies on the toxicity of commonly used biomaterials for applications in dentistry. It will help clinicians to formulate a methodical approach for the selection of dental biomaterials, thus providing an awareness for forecasting their risk of toxic reactions.
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http://dx.doi.org/10.1039/d1bm00233cDOI Listing
May 2021

Sore Mouth.

Am J Med 2021 04 28;134(4):e270. Epub 2020 Sep 28.

Division of Clinical Dentistry, School of Dentistry, International Medical University, Kuala Lumpur, Malaysia.

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http://dx.doi.org/10.1016/j.amjmed.2020.08.031DOI Listing
April 2021

Recent advances of gold nanoparticles as biomaterial in dentistry.

Int J Pharm 2020 Aug 2;586:119596. Epub 2020 Jul 2.

Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India. Electronic address:

Major goal of dental treatment is to eradicate the existing diseases of the oral cavity and implement preventive measures to control the spread of the diseases. Various interventions are being used to cure the dental diseases. Due to the nanostructures, high surface volume and biocompatibility, Gold nanoparticles (GNPs) have been experimented in the treatment of gum diseases, dental caries, tissue engineering, dental implantology and diagnosis of cancers. GNPs possess antifungal and antibacterial activity, hence are incorporated in various biomaterials to potentiate the effect. They also enhance the mechanical properties of materials leading to improved outcomes. They are available in different sizes and concentrations to exhibits its beneficial outcomes. These properties of GNPs make these materials as choice of fillers in biomaterials. This review aims to discuss the effect of incorporation of GNPs in several biomaterials used for dental and medical applications.
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http://dx.doi.org/10.1016/j.ijpharm.2020.119596DOI Listing
August 2020

Carcinoma ex pleomorphic adenoma: a case report and review of literature.

Afr Health Sci 2019 Dec;19(4):3253-3263

Department of Restorative Dentistry, King Khalid University, Abha, Kingdom of Saudi Arabia, Pincode- 61471.

Background: Carcinoma ex pleomorphic adenoma (CA-ex-PA) is extremely unusual in minor salivary glands of oral cavity. CAex-PA is a carcinomatous change as a primary or as a recurrence of pleomorphic adenoma.

Objective: Due to resemblance of clinical symptoms of Ca ex PA and benign pleomorphic adenoma, it is mandatory for surgeons to keep high degree of clinical alertness, considering the peculiarity of this tumor.

Case Report: 54-year-old male presented with swelling on left side in the pre-auricular region from the middle of zygomatic arch to mastoid process and from tragus of the ear up to angle of mandible. Fine needle aspiration cytology revealed a mixture of benign and malignant components. Total left parotidectomy with left radical neck dissection followed by reconstruction with cervicodeltopectoral flap was performed. Combination of chemotherapy and radiotherapy were given to patient. Histologic examination and pre-operative fine needle aspiration cytology confirmed the diagnosis of Carcinoma ex pleomorphic adenoma (CA-ex-PA). Two-year follow-up of patient showed no recurrence of the lesion.

Conclusion: Due to the similarity in the clinical symptoms of CA-ex-PA and benign pleomorphic adenoma, it is vital that clinicians maintain a high degree of clinical vigilance, considering the oddity of this malignancy.
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http://dx.doi.org/10.4314/ahs.v19i4.50DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040348PMC
December 2019

The potential of dendrimer in delivery of therapeutics for dentistry.

Heliyon 2019 Oct 23;5(10):e02544. Epub 2019 Oct 23.

Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India.

Dendrimers are hyperbranched nanoparticle structures along with its surface modifications can to be used in dental biomaterials for biomimetic remineralisation of enamel and dentin. The review highlights the therapeutic applications of dendrimers in the field of dentistry. It addresses the possible mechanisms of enhancement of mechanical properties of adhesives and resins structure. Dendrimers due to its unique construction of possessing inner hydrophobic and outer hydrophilic structure can act as drug carrier for delivery of antimicrobial drugs for treatment of periodontal diseases and at peripheral dental implant areas. Dendrimers due to its hyperbranched structures can provides a unique drug delivery vehicle for delivery of a drug at specific site for sustained release for therapeutic effects. Thus, dendrimers can be one of the most important constituents which can be incorporated in dental biomaterials for better outcomes in dentistry.
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http://dx.doi.org/10.1016/j.heliyon.2019.e02544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820096PMC
October 2019

Bony Bump of the Oral Cavity.

Am J Med 2019 10 17;132(10):e737. Epub 2019 May 17.

Division of Clinical Dentistry, School of Dentistry, International Medical University, Kuala Lumpur, Malaysia. Electronic address:

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http://dx.doi.org/10.1016/j.amjmed.2019.04.039DOI Listing
October 2019

Strawberry Marks on Lip.

Am J Med 2019 04 30;132(4):e538-e539. Epub 2018 Nov 30.

Department of Physiology, Faculty of Medicine, University Malaya Kuala Lumpur, Malaysia.

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http://dx.doi.org/10.1016/j.amjmed.2018.11.019DOI Listing
April 2019

Honiton Laces in Oral Cavity.

Am J Med Sci 2018 12 1;356(6):e43. Epub 2018 Aug 1.

Division of Clinical Dentistry, School of Dentistry, International Medical University, Kuala Lumpur, Malaysia.

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http://dx.doi.org/10.1016/j.amjms.2018.07.009DOI Listing
December 2018

The use of nanoparticles as biomaterials in dentistry.

Drug Discov Today 2019 01 31;24(1):85-98. Epub 2018 Aug 31.

Department of Pharmaceutical Technology, The International Medical University, Jalan Jalil Perkasa 19, Kuala Lumpur 57000, Malaysia. Electronic address:

Maintenance of oral health is a major challenge in dentistry. Different materials have been used to treat various dental diseases, although treatment success is limited by features of the biomaterials used. To overcome these limitations, materials incorporated with nanoparticles (NPs) can be used in dental applications including endodontics, periodontics, tissue engineering, oral surgery, and imaging. The unique properties of NPs, including their surface:volume ratio, antibacterial action, physical, mechanical, and biological characteristics, and unique particle size have rendered them effective vehicles for dental applications. In this review, we provide insights into the various applications of NPs in dentistry, including their benefits, limitations, properties, actions and future potential.
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http://dx.doi.org/10.1016/j.drudis.2018.08.012DOI Listing
January 2019

An overview of application of silver nanoparticles for biomaterials in dentistry.

Mater Sci Eng C Mater Biol Appl 2018 Oct 25;91:881-898. Epub 2018 May 25.

International Medical University, School of Pharmacy, Department of Pharmaceutical Technology, 57000 Kuala Lumpur, Malaysia. Electronic address:

Oral cavity is a gateway to the entire body and protection of this gateway is a major goal in dentistry. Plaque biofilm is a major cause of majority of dental diseases and although various biomaterials have been applied for their cure, limitations pertaining to the material properties prevent achievement of desired outcomes. Nanoparticle applications have become useful tools for various dental applications in endodontics, periodontics, restorative dentistry, orthodontics and oral cancers. Off these, silver nanoparticles (AgNPs) have been used in medicine and dentistry due to its antimicrobial properties. AgNPs have been incorporated into biomaterials in order to prevent or reduce biofilm formation. Due to greater surface to volume ratio and small particle size, they possess excellent antimicrobial action without affecting the mechanical properties of the material. This unique property of AgNPs makes these materials as fillers of choice in different biomaterials whereby they play a vital role in improving the properties. This review aims to discuss the influence of addition of AgNPs to various biomaterials used in different dental applications.
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http://dx.doi.org/10.1016/j.msec.2018.05.069DOI Listing
October 2018

Oral Thrush.

Am J Med 2018 09 3;131(9):e371-e372. Epub 2018 May 3.

Periodontology and Oral Implantology, Division of Clinical Dentistry, School of Dentistry, International Medical University, Kuala Lumpur, Malaysia. Electronic address:

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http://dx.doi.org/10.1016/j.amjmed.2018.04.020DOI Listing
September 2018

Mulberry-Shaped Gingival Overgrowth Induced by Amlodipine and Cyclosporine.

Am J Med Sci 2017 Dec 18;354(6):e13. Epub 2017 Aug 18.

Department of Periodontics, D.Y.Patil University School of Dentistry, Nerul, Navi Mumbai, Maharashtra, India.

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http://dx.doi.org/10.1016/j.amjms.2017.08.008DOI Listing
December 2017

Allergic contact dermatitis caused by polymethylmethacrylate following intradermal filler injection.

Contact Dermatitis 2017 Dec;77(6):407-408

Department of Periodontology and Oral Implantology, D. Y. Patil School of Dentistry, 400706, Navi Mumbai, Maharashtra, India.

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http://dx.doi.org/10.1111/cod.12779DOI Listing
December 2017

Allergic contact stomatitis caused Salvadora persica in toothpaste.

Contact Dermatitis 2017 Nov;77(5):325-326

Cosmetic Dentist, Mumbai 400091, India.

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http://dx.doi.org/10.1111/cod.12819DOI Listing
November 2017

Squamous-Cell Carcinoma of the Mouth.

N Engl J Med 2017 Sep;377(12):1188

International Medical University, Kuala Lumpur, Malaysia.

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http://dx.doi.org/10.1056/NEJMicm1701886DOI Listing
September 2017

Allergic contact stomatitis caused by camphorquinone in a light cure periodontal dressing.

Contact Dermatitis 2017 Oct;77(4):251-252

Department of Periodontics, D. Y. Patil School of Dentistry, Nerul, Navi Mumbai, 400706, India.

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http://dx.doi.org/10.1111/cod.12794DOI Listing
October 2017

Geographic Tongue.

Am J Med 2017 Dec 14;130(12):e533-e534. Epub 2017 Jul 14.

Division of Clinical Dentistry, School of Dentistry, International Medical University, Kuala Lumpur, Malaysia.

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http://dx.doi.org/10.1016/j.amjmed.2017.06.016DOI Listing
December 2017

Trench Mouth.

Am J Med 2017 Nov 8;130(11):e493-e494. Epub 2017 Jun 8.

Division of Clinical Dentistry, School of Dentistry, International Medical University, Kuala Lumpur, Malaysia.

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http://dx.doi.org/10.1016/j.amjmed.2017.05.020DOI Listing
November 2017

Torus Mandibularis.

Am J Med 2017 10 19;130(10):e451. Epub 2017 May 19.

Private Practice, Navi Mumbai, Maharashtra, India.

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http://dx.doi.org/10.1016/j.amjmed.2017.04.026DOI Listing
October 2017

Allergic contact dermatitis caused by latex gloves in a dental undergraduate student.

Contact Dermatitis 2016 Oct;75(4):256-7

Department of Periodontology and Oral Implantology, DY Patil University School of Dentistry, 400706, Navi Mumbai, India.

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http://dx.doi.org/10.1111/cod.12625DOI Listing
October 2016

Ankyloglossia and its management.

J Indian Soc Periodontol 2011 Jul;15(3):270-2

Department of Periodontics, Nair Hospital Dental College, Mumbai, Maharashtra, India.

Ankyloglossia or tongue-tie is the result of a short, tight, lingual frenulum causing difficulty in speech articulation due to limitation in tongue movement. In this article, we have reported a 24-year-old male with tongue-tie who complained of difficulty in speech following which he underwent frenectomy procedure under local anesthesia without any complications. Finally, he was given speech therapy sessions.
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http://dx.doi.org/10.4103/0972-124X.85673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200025PMC
July 2011
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