Publications by authors named "Tan Wang"

89 Publications

Analysis of the factors influencing retrograde removal of double J ureteral stents using a simple snare technique in female patients.

Ann Transl Med 2021 Apr;9(8):674

Department of Interventional Radiology, Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.

Background: To identify the factors related to the effectiveness of retrograde removal of double J ureteral stents using a simple snare technique in female patients.

Methods: It was a retrospective observational study. From 2012 to 2017, 128 female patients underwent fluoroscopy-guided, retrograde double J stent removal with or without replacement using a simple snare technique. The position of the tip of the double J stent in the urinary bladder was classified according to position types A, B, C, and D, corresponding to the ipsilateral lateral, ipsilateral medial, contralateral medial, and contralateral lateral quadrants of the urinary bladder, respectively. The factors influencing the fluoroscopy time upon removal of the double J stent were analyzed.

Results: Technical success rate of 312 procedures performed was 97.44% (304/312) with the mean fluoroscopy time of 12.68±7.34 minutes. Eight double J stent removal procedures failed, and all of these occurred in the position type D patients. The position type and the number of curls of the double J stent had a significant influence on the fluoroscopy time (P<0.05). In addition, multiple regression analysis demonstrated that the position type and number of curls in the double J stent were factors independently influenced the fluoroscopy time (P=0.001). Type D exhibited the longest fluoroscopy time followed by types B and C, and type A had the shortest fluoroscopy time. There were only minor complications consisting of urethral orifice pain (5.1%, 16/312) or gross hematuria (3.2%, 10/312), all resolved conservatively within 24 hours.

Conclusions: The position type and the number of curls in a double J stent have a significant influence on the effectiveness of retrograde removal of double J stents using a simple snare technique in female patients.
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http://dx.doi.org/10.21037/atm-21-1113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8106078PMC
April 2021

The well responsiveness of drug-resistant focal seizures in anti-AMPA2 receptor encephalitis to perampanel treatment.

Neurol Sci 2021 May 12. Epub 2021 May 12.

Department of Neurology, Qilu Hospital, Shandong University, Jinan, 250012, Shandong, China.

Anti-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor encephalitis is an anti-neuronal surface antigen autoimmune encephalitis and is relatively rare. Our study evaluated a patient who developed anti-AMPA2 receptor encephalitis with memory deficits and refractory focal seizures as paroxysmal jerking on right face as well as dystonic seizure on right hand. On this patient, the combination treatment of levetiracetam, carbamazepine, and clonazepam, monthly periodic intravenous immunoglobin and immunosuppressive therapies for 5 months was not effective for the focal seizures, while his memory loss was slightly improved. However, adjunctive perampanel treatment led to a rapid relief of seizures. Perampanel is suggested in seizures associated with anti-AMPA receptor encephalitis by directly attenuating nerve hyperexcitability caused by glutamate and Ca2+-permeable GluA4 subunit of AMPA receptors.
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http://dx.doi.org/10.1007/s10072-021-05306-yDOI Listing
May 2021

Genome wide analysis of kinesin gene family in Citrullus lanatus reveals an essential role in early fruit development.

BMC Plant Biol 2021 May 10;21(1):210. Epub 2021 May 10.

State Key Laboratory of Crop Stress Biology for Arid Areas, College of Horticulture, Northwest A&F University, Yangling, 712100, Shaanxi, China.

Background: Kinesin (KIN) as a motor protein is a versatile nano-machine and involved in diverse essential processes in plant growth and development. However, the kinesin gene family has not been identified in watermelon, a valued and nutritious fruit, and yet their functions have not been characterized. Especially, their involvement in early fruit development, which directly determines the size, shape, yield and quality of the watermelon fruit, remains unclear.

Results: In this study, we performed a whole-genome investigation and comprehensive analysis of kinesin genes in C. lanatus. In total, 48 kinesins were identified and categorized into 10 kinesin subfamilies groups based on phylogenetic analysis. Their uneven distribution on 11 chromosomes was revealed by distribution analysis. Conserved motif analysis showed that the ATP-binding motif of kinesins was conserved within all subfamilies, but not the microtubule-binding motif. 10 segmental duplication pairs genes were detected by the syntenic and phylogenetic approaches, which showed the expansion of the kinesin gene family in C. lanatus genome during evolution. Moreover, 5 ClKINs genes are specifically and abundantly expressed in early fruit developmental stages according to comprehensive expression profile analysis, implying their critical regulatory roles during early fruit development. Our data also demonstrated that the majority of kinesin genes were responsive to plant hormones, revealing their potential involvement in the signaling pathways of plant hormones.

Conclusions: Kinesin gene family in watermelon was comprehensively analyzed in this study, which establishes a foundation for further functional investigation of C. lanatus kinesin genes and provides novel insights into their biological functions. In addition, these results also provide useful information for understanding the relationship between plant hormone and kinesin genes in C. lanatus.
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http://dx.doi.org/10.1186/s12870-021-02988-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8108342PMC
May 2021

Percutaneous gastrostomy compared with esophageal stenting for the treatment of esophageal cancer with dysphagia.

J Vasc Interv Radiol 2021 May 3. Epub 2021 May 3.

Minimally Invasive and Interventional Department, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450008, Henan, China. Electronic address:

Purpose: To compare the outcomes of self-expandable metal stent and percutaneous gastrostomy (PG) for treatment of patients with esophageal cancer (EC) and dysphagia.

Materials And Methods: This retrospective observational study consisted of 113 patients with EC and dysphagia who underwent either stent insertion (n = 47) or PG (n = 66) at a single center between June 2014 and June 2018.

Results: There were 63 men and 50 women with the mean age of 76.5 ± 4.9 years. The two groups had similar baseline characteristics, except that the PG group had a higher percentage of patients with cervical EC (22.7%. vs 2.1%, P < 0.001). The PG group had better maintenance of nutritional status in terms of reduction of serum albumin level (P = 0.039) and weight loss (P = 0.041). Compared with the stent group, the PG group demonstrated a lower incidence of local severe pain (0% vs 21.3%, P < 0.001), and lower incidence of dislodgment of device (1.5% vs 19.1%, P = 0.002). The PG group demonstrated longer overall survival than the stent group, for stages II and III (201 vs 185 days, P = 0.034) and stage IV (122 vs 86 days, P = 0.001).

Conclusion: Compared with stent insertion, PG is associated with better maintenance of nutritional status, fewer complications, and better survival. Thus, PG may be the preferred choice for treating malnutrition in patients with EC and dysphagia.
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http://dx.doi.org/10.1016/j.jvir.2021.04.019DOI Listing
May 2021

Determination of 1-methylcyclopropene residues in vegetables and fruits based on iodine derivatives.

Food Chem 2021 Oct 20;358:129854. Epub 2021 Apr 20.

Pesticide Safety Evaluation Research Center, Institute for Agro-food Standards and Testing Technology, Shanghai Academy of Agricultural Sciences, Shanghai 2011106, China. Electronic address:

An innovative method was established for the determination of 1-methylcyclopropene (1-MCP) in vegetables and fruits. Due to its small molecular weight and low boiling point, it was difficult to obtain quantitative analysis for 1-MCP, especially at the residual level. In this work, based on its iodine derivatives, 1-MCP was derived to 1,2-diiodo-1-methylcyclopropane, which was much easier for trace and accurate chromatographic analysis. During the method validation, the method validation results were satisfactory in terms of linearity (4 ~ 400 µg/L, and R ≥ 0.959), matrix effect (-89% ~ -13%), accuracy (80 ~ 100%), sensitivity (limits of quantification, 5 μg/kg) and precision (relative standard deviations ≤ 19%), which was in accordance with the Chinese guidelines for the testing of pesticide residues in crops. Finally, the proposed analytical method was used to monitor the 1-MCP residue levels in commercially available samples, and all the values were below 5 µg/kg, which satisfied the EU or Japan MRLs of 1-MCP.
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http://dx.doi.org/10.1016/j.foodchem.2021.129854DOI Listing
October 2021

Dopamine receptor DOP-1 engages a sleep pathway to modulate swimming in .

iScience 2021 Apr 1;24(4):102247. Epub 2021 Mar 1.

Basic Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N., Seattle, WA 98109, USA.

Animals require robust yet flexible programs to support locomotion. Here we report a pathway that connects the D1-like dopamine receptor DOP-1 with a sleep mechanism to modulate swimming in . We show that DOP-1 plays a negative role in sustaining swimming behavior. By contrast, a pathway through the D2-like dopamine receptor DOP-3 negatively regulates the initiation of swimming, but its impact fades quickly over a few minutes. We find that DOP-1 and the GPCR kinase (G-protein-coupled receptor kinase-2) function in the sleep interneuron RIS, where DOP-1 modulates the secretion of a sleep neuropeptide FLP-11. We further show that DOP-1 and FLP-11 act in the same pathway to modulate swimming. Together, these results delineate a functional connection between a dopamine receptor and a sleep program to regulate swimming in . The temporal transition between DOP-3 and DOP-1 pathways highlights the dynamic nature of neuromodulation for rhythmic movements that persist over time.
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http://dx.doi.org/10.1016/j.isci.2021.102247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995527PMC
April 2021

First Report of Causing Stem and Leaf Rot on Muskmelon in China.

Plant Dis 2021 Jan 28. Epub 2021 Jan 28.

Shanghai Academy of Agricultural Sciences, 74594, Horticultural Research Institute, Shanghai, China;

Muskmelon ( L.) is an important economic crop in China, which is planted on more than 376, 000 hectares with over 13 million tons of annual fruit production. In February 2020, a serious bacterial stem and leaf rot disease on muskmelon plants was observed in greenhouses in Liguo Town, Ledong County, Hainan Province, China (18.54° N, 108.87° E), with disease incidences being approximately 10 to 12%. Initially, soft rot symptoms appeared on petioles and stems, showing yellow bacterial ooze signs, which was different from the milky white ooze produced by infection. The infected tissues of petioles, stems, and leaves eventually developed into browning and withering symptoms. To isolate and identify the causal agent, the lesion tissues were sterilized by immersion in 75% ethanol for 30 s, washed three times with sterile water, and then cut and soaked in 1 ml of distilled water for 10 min. The suspension was serially diluted and spread on Luria-Bertani agar (LB) medium. After incubation at 28°C for 24 to 36 h, the resulted bacterial colonies were tiny and were streaked on LB plate for further culture. After purification, the colonies were yellow, circular, smooth-margined, and two independent representative isolates CM-11 and CM-12 were used for further validation experiments. The electron microscope analysis showed that the pathogen was rod-shaped, with a length of 1.34 ± 0.22 μm and a width of 0.54 ± 0.06 μm (N=50), and had a single terminal flagellum. The gram staining of the two isolates was negative. Moreover, the tested strains were positive for catalase but negative for oxidase and were able to utilize D-glucose, L-arabinose, and D-mannitol. Morphological, physiological, and biochemical characteristics of both isolates were consistent with those of spp. To verify the species identity of the bacterial pathogens, genomic DNA of isolates CM-11 and CM-12 was extracted and several conserved genes were amplified and sequenced, including the 16S rRNA gene with primers 27F/1492R (GenBank MW187499 and MW187500), rpoB gene with primers V4/LAPS27 (MW201910 and MW446819), and gyrB gene with primers gyrBBAUP2/APrU (MW187501 and MW187502) (Mulet et al. 2010). In the BLAST analysis, the 16S rRNA sequences showed a 99% similarity to that of strains TH19 (LC026009), AA21 (MG571765). The rpoB and gyrB sequences showed high similarity (> 98%) to strains FDAARGOS_657. The phylogenetic tree analysis of rpoB and gyrB genes further verified that the two isolates CM-11 and CM-12 were most closely related to species. Consequently, the two pathogenic isolates CM-11 and CM-12 were identified as . Both strains of CM-11 and CM-12 were tested to accomplish Koch's postulates. Young branches of muskmelons (cultivar Yugu, 10 days after pollination) were chosen as the material for inoculation. Ten healthy detached branches were placed in 15 ml tubes by submerging the cutting wound in 5 ml of the bacterial suspension (10 CFU/ml). Ten additional branches were implemented with sterilized distilled water as a negative control. The inoculated branches were placed in a plastic box containing moistened paper at 28°C. Rotting symptoms appeared within 5 days after infection, while the control samples remained healthy. Bacteria were re-isolated from diseased tissues, and the 16S rRNA gene sequences of the isolates showed the same as those from the original pathogen. Panicle blight and grain discoloration disease caused by on rice has been described in China (Hou et al. 2020). It's also recently found that caused center blackening disease on muskmelon fruit in Korea (Choi et al. 2019). This study indicated that it was a causative agent of stem and leaf rot disease during the field growth period. To the best of our knowledge, this is the first report of causing muskmelon stem rot in China.
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http://dx.doi.org/10.1094/PDIS-01-21-0100-PDNDOI Listing
January 2021

A prognostic score model for predicting the survival benefits of patients undergoing sorafenib plus transarterial chemoembolization for hepatocellular carcinoma with portal vein invasion.

Abdom Radiol (NY) 2021 05 1;46(5):1967-1976. Epub 2021 Jan 1.

Department of Radiology, The Seventh Affiliated Hospital, Sun Yat-sen University, 628 Zhenyuan Road, Shenzhen, 518107, China.

Purpose: The survival benefits and which patients with advanced hepatocellular carcinoma (HCC) would benefit from sorafenib plus transarterial chemoembolization (TACE) therapy remain controversial. We aimed to develop a prognostic score model for predicting different prognoses of patients with HCC and portal vein invasion who received sorafenib plus TACE.

Methods: This observational study included 167 patients with HCC and portal vein invasion undergoing sorafenib combined with TACE from January 2013 to June 2018 at two hospitals. Multivariate Cox regression analysis was performed using a training cohort (n = 83) to identify critical factors associated with survival. Then, a prognostic score model was established to classify different outcomes and confirmed using a validation cohort (n = 84).

Results: Three factors were determined to critically impact survival in the training cohort: portal vein invasion extent, sorafenib-related dermatologic response, and initial radiological response. Using the β-coefficients of these factors, a prognostic score was calculated, and the survival time decreased as the score increased. Based on the prognostic score model, three different prognoses of patients with 0 points, 2-3 points, and > 3 points were stratified with a median survival of 38.0 months, 20.0 months, and 7.0 months, respectively (P < 0.001). Time to progression was also significantly different using the same prognostic index. The prognostic score model was confirmed by the validation cohort.

Conclusion: Sorafenib plus TACE is a potential therapy for selected HCC patients with portal vein invasion. This prognostic score model can predict the survival benefits for these patients.
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http://dx.doi.org/10.1007/s00261-020-02897-6DOI Listing
May 2021

Decreased expression of the long non-coding RNA promotes gastric cancer progression by targeting HOXD8 and activating PI3K/Akt signaling pathway.

World J Gastrointest Oncol 2020 Nov;12(11):1237-1254

Department of Gastrointestinal Surgery, Clinical Medical College and The First Affiliated Hospital of Chengdu Medical College, Chengdu 610000, Sichuan Province, China.

Background: Long non-coding RNAs (lncRNAs) have been shown to be associated with many tumors. However, the specific mechanism of lncRNAs in the occurrence and development of gastric cancer (GC) has not been fully elucidated.

Aim: To explore the expression level and molecular mechanism of in GC tissues and cells, and analyze its significance in the prognosis of GC.

Methods: Real-time quantitative PCR was used to detect the expression of in 79 pairs of GC tissues and five cell lines. The pc plasmid vector was constructed and transfected into SGC-7901 and SNU-1 GC cells. Matrigel Transwell and wound healing assays were used to confirm the effect of on invasion and migration of GC cells. Cell counting kit-8 assay and flow cytometry were used to verify the effect of on the proliferation, cell cycle, and apoptosis of GC cells. The relevant regulatory mechanism between and and PI3K/Akt signaling pathway was verified by Western blot analysis.

Results: The low expression of lncRNA was associated with lymph node metastasis and tumor-node-metastasis stage in GC. functional experiments demonstrated that overexpression of inhibited GC cell progression. Mechanistic studies revealed that regulated the expression of its nearby gene and inhibited the activity of the PI3K/Akt signaling pathway.

Conclusion: These results indicate that downregulation of significantly promotes the progression of GC cells by regulating expression and activating the PI3K/Akt signaling pathway. may be a novel diagnostic biomarker and effective therapeutic target for GC.
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http://dx.doi.org/10.4251/wjgo.v12.i11.1237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7667460PMC
November 2020

IL-23 skin and joint profiling in psoriatic arthritis: novel perspectives in understanding clinical responses to IL-23 inhibitors.

Ann Rheum Dis 2020 Nov 26. Epub 2020 Nov 26.

Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK

Objectives: To determine the relationship between synovial versus skin transcriptional/histological profiles in patients with active psoriatic arthritis (PsA) and explore mechanistic links between diseased tissue pathology and clinical outcomes.

Methods: Twenty-seven active PsA patients were enrolled in an observational/open-label study and underwent biopsies of synovium and paired lesional/non-lesional skin before starting anti-tumour necrosis factor (TNF) (if biologic-naïve) or ustekinumab (if anti-TNF inadequate responders). Molecular analysis of 80-inflammation-related genes and protein levels for interleukin (IL)-23p40/IL-23p19/IL-23R were assessed by real-time-PCR and immunohistochemistry, respectively.

Results: At baseline, all patients had persistent active disease as per inclusion criteria. At primary end-point (16-weeks post-treatment), skin responses favoured ustekinumab, while joint responses favoured anti-TNF therapies. Principal component analysis revealed distinct clustering of synovial tissue gene expression away from the matched skin. While and were homogeneously expressed in lesional skin, their expression was extremely heterogeneous in paired synovial tissues. Here, IL-23 transcriptomic/protein expression was strongly linked to patients with high-grade synovitis who, however, were not distinguishable by conventional clinimetric measures.

Conclusions: PsA synovial tissue shows a heterogeneous IL-23 axis profile when compared with matched skin. Synovial molecular pathology may help to identify among clinically indistinguishable patients those with a greater probability of responding to IL-23 inhibitors.
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http://dx.doi.org/10.1136/annrheumdis-2020-218186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8053336PMC
November 2020

Sinonasal mucosal melanoma: a 10-year experience of 36 cases in China.

Ann Transl Med 2020 Aug;8(16):1022

Ear Institute, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Background: Sinonasal mucosal melanoma (SNMM) is a rare tumor with a poor prognosis. This study aimed to assess the clinical and imaging features, progression, treatment, and possible prognostic factors of SNMM.

Methods: Thirty-six patients with SNMM were retrospectively reviewed in the Department of Otolaryngology & Head and Neck Surgery of Xinhua Hospital from January 2008 to December 2017.

Results: The age of the first diagnosis was 67.4±10.8 years; the most common clinical symptoms included epistaxis, nasal obstruction, headache, and facial pain. Most tumors originated in the nasal cavity (63.9%) and at stage IV (77.8%). Melanin in melanoma showed typical signal intensity on magnetic resonance imaging (MRI), T1WI had high signal while T2WI had low signal. 41.6% of patients had the typical MRI findings. Treatment included surgery, surgery with radiotherapy, and radiotherapy only. The follow-up time ranged from 4 to 96 months, with a median time of 22 months, 1-, 3-, and 5-year OS is 80.6%, 36.1%, and 13.9%, respectively. The 3-year OS was better in cases in the T3 stage than the T4 stage (P=0.02). However, tumors that originated from the paranasal sinus had a poorer prognosis than the nasal cavity (P=0.04). The cases receiving postoperative radiotherapy showed poorer prognosis (P=0.02). Other factors were not found to be associated with prognosis, including gender, age, lymph node metastasis, distant metastasis, computed tomography (CT) enhancement, and typical MRI findings.

Conclusions: The SNMM was a devastating tumor with poor outcomes; most cases were diagnosed at late stages, which may account for poor prognosis. Tumors with melanin feature MRI findings do not have a better prognosis. The treatment of postoperative radiotherapy is still controversial.
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http://dx.doi.org/10.21037/atm-20-5575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7475479PMC
August 2020

A One-Step, Streamlined Children's Vision Screening Solution Based on Smartphone Imaging for Resource-Limited Areas: Design and Preliminary Field Evaluation.

JMIR Mhealth Uhealth 2020 07 13;8(7):e18226. Epub 2020 Jul 13.

TerryDr Infomation Technology, Nanjing, China.

Background: Young children's vision screening, as part of a preventative health care service, produces great value for developing regions. Besides yielding a high return on investment from forestalling surgeries using a low-cost intervention at a young age, it improves school performance and thus boosts future labor force quality. Leveraging low-skilled health care workers with smartphones and automated diagnosis to offer such programs can be a scalable model in resource-limited areas.

Objective: This study aimed to develop and evaluate an effective, efficient, and comprehensive vision screening solution for school children in resource-limited areas. First, such an exam would need to cover the major risk factors of amblyopia and myopia, 2 major sources of vision impairment effectively preventable at a young age. Second, the solution must be integrated with digital patient record-keeping for long-term monitoring and popular statistical analysis. Last, it should utilize low-skilled technicians and only low-cost tools that are available in a typical school in developing regions, without compromising quality or efficiency.

Methods: A workflow for the screening program was designed and a smartphone app was developed to implement it. In the standardized screening procedure, a young child went through the smartphone-based photoscreening in a dark room. The child held a smartphone in front of their forehead, displaying pre-entered personal information as a quick response code that duplexed as a reference of scale. In one 10-second procedure, the child's personal information and interpupillary distance, relative visual axis alignment, and refractive error ranges were measured and analyzed automatically using image processing and artificial intelligence algorithms. The child's risk for strabismus, myopia, and anisometropia was then derived and consultation given.

Results: A preliminary evaluation of the solution was conducted alongside yearly physical exams in Luoyang, Henan, People's Republic of China. It covered 20 students with suspected strabismus and 80 randomly selected students, aged evenly between 8 and 10. Each examinee took about 1 minute, and a streamlined workflow allowed 3 exams to run in parallel. The 1-shot and 2-shot measurement success rates were 87% and 100%, respectively. The sensitivity and specificity of strabismus detection were 0.80 and 0.98, respectively. The sensitivity and specificity of myopia detection were 0.83 and 1.00, respectively. The sensitivity and specificity of anisometropia detection were 0.80 and 1.00, respectively.

Conclusions: The proposed vision screening program is effective, efficient, and scalable. Compared with previously published studies on utilizing a smartphone for an automated Hirschberg test and photorefraction screening, this comprehensive solution is optimized for practicality and robustness, and is thus better ready-to-deploy. Our evaluation validated the achievement of the program's design specifications.
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http://dx.doi.org/10.2196/18226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7386401PMC
July 2020

Profiles of COVID-19 clinical trials in the Chinese Clinical Trial Registry.

Emerg Microbes Infect 2020 Dec;9(1):1695-1701

Neurology Department, The Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, People's Republic of China.

The COVID-19 pandemic has caused a global public health crisis. There is a pressing need for evidence-based interventions to address the devastating clinical and public health effects of the COVID-19 pandemic. The Chinese scientists supported by private and government resources have adopted extensive efforts to identify effective drugs against the virus. To date, a large number of clinical trials addressing various aspects of COVID19 have been registered in the Chinese Clinical Trial Registry (ChiCTR), including more than 200 interventional studies. Under such an urgent circumstance, the scope and quality of these clinical studies vary significantly. Hence, this review aims to make a comprehensive analysis on the profiles of COVID-19 clinical trials registered in the ChiCTR, including a wide range of characteristics. Our findings will provide a useful summary on these clinical studies since most of these studies will encounter major challenges from the design to completion. It will be a long road for the outcomes of these studies to be published and international collaboration will help the ultimate goals of developing new vaccines and anti-viral drugs.
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http://dx.doi.org/10.1080/22221751.2020.1791736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7473047PMC
December 2020

Semi-Flooded Sulfur Cathode with Ultralean Absorbed Electrolyte in Li-S Battery.

Adv Sci (Weinh) 2020 May 18;7(9):1903168. Epub 2020 Mar 18.

Department of Nuclear Science and Engineering and Department of Materials Science and Engineering Massachusetts Institute of Technology Cambridge MA 02139 USA.

Lean electrolyte (small E/S ratio) is urgently needed to achieve high practical energy densities in Li-S batteries, but there is a distinction between the cathode's absorbed electrolyte (AE) which is cathode-intrinsic and total added electrolyte (E) which depends on cell geometry. While total pore volume in sulfur cathodes affects AE/S and performance, it is shown here that pore morphology, size, connectivity, and fill factor all matter. Compared to conventional thermally dried sulfur cathodes that usually render "open lakes" and closed pores, a freeze-dried and compressed (FDS-C) sulfur cathode is developed with a canal-capillary pore structure, which exhibits high mean performance and greatly reduces cell-to-cell variation, even at high sulfur loading (14.2 mg cm) and ultralean electrolyte condition (AE/S = 1.2 µL mg). Interestingly, as AE/S is swept from 2 to 1.2 µL mg, the electrode pores go from fully flooded to semi-flooded, and the coin cell still maintains function until (AE/S) ≈ 1.2 µL mg is reached. When scaled up to Ah-level pouch cells, the full-cell energy density can reach 481 Wh kg as its E/S ≈ AE/S ratio can be reduced to 1.2 µL mg, proving high-performance pouch cells can actually be working in the ultralean, semi-flooded regime.
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http://dx.doi.org/10.1002/advs.201903168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201250PMC
May 2020

Radial Graph Convolutional Network for Visual Question Generation.

IEEE Trans Neural Netw Learn Syst 2021 Apr 2;32(4):1654-1667. Epub 2021 Apr 2.

In this article, we address the problem of visual question generation (VQG), a challenge in which a computer is required to generate meaningful questions about an image targeting a given answer. The existing approaches typically treat the VQG task as a reversed visual question answer (VQA) task, requiring the exhaustive match among all the image regions and the given answer. To reduce the complexity, we propose an innovative answer-centric approach termed radial graph convolutional network (Radial-GCN) to focus on the relevant image regions only. Our Radial-GCN method can quickly find the core answer area in an image by matching the latent answer with the semantic labels learned from all image regions. Then, a novel sparse graph of the radial structure is naturally built to capture the associations between the core node (i.e., answer area) and peripheral nodes (i.e., other areas); the graphic attention is subsequently adopted to steer the convolutional propagation toward potentially more relevant nodes for final question generation. Extensive experiments on three benchmark data sets show the superiority of our approach compared with the reference methods. Even in the unexplored challenging zero-shot VQA task, the synthesized questions by our method remarkably boost the performance of several state-of-the-art VQA methods from 0% to over 40%. The implementation code of our proposed method and the successfully generated questions are available at https://github.com/Wangt-CN/VQG-GCN.
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http://dx.doi.org/10.1109/TNNLS.2020.2986029DOI Listing
April 2021

Is Essential for Melanin Biosynthesis and Pathogenicity of .

Pathogens 2020 Feb 20;9(2). Epub 2020 Feb 20.

School of Life Sciences, East China Normal University, Shanghai 200241, China.

, an important phytopathogenic fungus, mainly infects tropical fruits and results in serious anthracnose. Previous studies have shown that melanin biosynthesis inhibitor can inhibit the melanization of the appressoria of and , resulting in limited infection of the hosts. In this study, we identified and characterized a scytalone dehydratase gene () from which is involved in melanin synthesis. The gene deletion mutant was obtained using homologous recombination. The mutant showed no melanin accumulation on appressoria formation and vegetative hyphae. Furthermore, the virulence of was significantly reduced in comparison with the wild-type (WT) strain. Further investigations showed that the growth rate as well as germination and appressorium formation of displayed no difference compared to the wild-type and complemented transformant Cgscd1 strains. Furthermore, we found that the appressorial turgor pressure in the mutant showed no difference compared to that in the WT and Cgscd1 strains in the incipient cytorrhysis experiment. However, fewer infectious hyphae of were observed in the penetration experiments, suggesting that the penetration ability of nonpigmented appressoria was partially impaired. In conclusion, we identified the gene, which is involved in melanin synthesis and pathogenicity, and found that the melanization defect did not affect appressorial turgor pressure in .
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http://dx.doi.org/10.3390/pathogens9020141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169410PMC
February 2020

Cross-Modal Attention With Semantic Consistence for Image-Text Matching.

IEEE Trans Neural Netw Learn Syst 2020 Dec 30;31(12):5412-5425. Epub 2020 Nov 30.

The task of image-text matching refers to measuring the visual-semantic similarity between an image and a sentence. Recently, the fine-grained matching methods that explore the local alignment between the image regions and the sentence words have shown advance in inferring the image-text correspondence by aggregating pairwise region-word similarity. However, the local alignment is hard to achieve as some important image regions may be inaccurately detected or even missing. Meanwhile, some words with high-level semantics cannot be strictly corresponding to a single-image region. To tackle these problems, we address the importance of exploiting the global semantic consistence between image regions and sentence words as complementary for the local alignment. In this article, we propose a novel hybrid matching approach named Cross-modal Attention with Semantic Consistency (CASC) for image-text matching. The proposed CASC is a joint framework that performs cross-modal attention for local alignment and multilabel prediction for global semantic consistence. It directly extracts semantic labels from available sentence corpus without additional labor cost, which further provides a global similarity constraint for the aggregated region-word similarity obtained by the local alignment. Extensive experiments on Flickr30k and Microsoft COCO (MSCOCO) data sets demonstrate the effectiveness of the proposed CASC on preserving global semantic consistence along with the local alignment and further show its superior image-text matching performance compared with more than 15 state-of-the-art methods.
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http://dx.doi.org/10.1109/TNNLS.2020.2967597DOI Listing
December 2020

Oral propranolol for treatment of the subgroups of essential tremor: a systematic review and meta-analysis protocol.

BMJ Open 2020 01 15;10(1):e032096. Epub 2020 Jan 15.

Department of Neurology, First Affiliated Hospital, Hainan Medical University, Haikou, Hainan, China

Introduction: Essential tremor (ET), a tremor disorder, is one of the most common movement disorders. Only oral drugs (propranolol, primidone, topiramate, etc)are still the first-line treatment recommended by the Food and Drug Administration. Propranolol is thought to potentially reduce upper limb action tremor. However, it has a poor effect on axial tremor symptoms, such as essential head tremor and voice tremor. Studies have shown that tremor severity develops over time, possibly producing other clinical tremors and neurological soft signs (such as memory loss, gait abnormalities, balance disorders, etc), which further increases the difficulty of treating tremors. However, some recent studies provide emerging evidence for oral propranolol on subgroups of ET, which is based on the anatomical distribution of ET (lower extremities, head, sound, tongue, etc). This systematic review aims to synthesise these new data to improve the efficacy of propranolol in ET subgroups.

Methods And Analysis: We will search for randomised controlled trials from the PubMed, MEDLINE, EMBASE, Cochrane Library, UptoDate and PEDro databases from inception to June 2019. All data will be extracted independently by two reviewers and compared at the end of the review. The two reviewers will screen the study quality, and the Cochrane Collaboration's tool in Review Manager (RevMan) V.5.3.3 will be used to evaluate risk of bias. Our primary outcome will be the functional disability component related to tremors, as measured by the Fahn-Tolosa-Marin Tremor Rating Scale subscales B and C. Secondary outcomes will include severity of tremors and quality of life. Narrative and meta-analytical syntheses are planned.

Ethics And Dissemination: Published aggregated data will be used in this review analysis and therefore no ethical approval is required. The results will be published in peer-reviewed journals, and proliferation activities will include diverse social stakeholders, non-academic groups and patients.

Prospero Registration Number: CRD42018112580.
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http://dx.doi.org/10.1136/bmjopen-2019-032096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044890PMC
January 2020

Cantharidin suppresses gastric cancer cell migration/invasion by inhibiting the PI3K/Akt signaling pathway via CCAT1.

Chem Biol Interact 2020 Feb 13;317:108939. Epub 2020 Jan 13.

The Department of Gastrointestinal Surgery, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, People's Republic of China. Electronic address:

Cantharidin (CTD) is a traditional Chinese medicine that shows an anticancer effects in multiple types of cancer cells. However, the mechanism of CTD anti-cancer function in gastric cancer (GC) is still unclear. The aim of the present study was to investigate the underlying mechanism that CTD inhibits proliferation and migration through suppression of the PI3K/Akt signaling. CTD induced GC cell apoptosis and inhibited metastasis measured by CCK8 assays as well as wound healing assays and transwell assays. Mechanistic investigations suggested that CTD modulated the PI3K/Akt signaling via western-blot and quantitative q-PCR. In addition, we identified and confirmed CCAT1 as a novel direct target of CTD inhibited PI3K/AKt signaling expression. In conclusion, our results provide new point into the critical role of CTD in suppressing PI3K/Akt signaling via down-regulation of CCAT1, resulting in suppression GC cell growth and migration/invasion.
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http://dx.doi.org/10.1016/j.cbi.2020.108939DOI Listing
February 2020

Clinicopathological characteristics of gastric cancer with carbohydrate antigen 19-9 expression occurring in elderly individuals: An autopsy study.

Pathol Int 2020 Feb 23;70(2):92-100. Epub 2019 Dec 23.

Departments of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan.

The clinicopathological significance of carbohydrate antigen 19-9 (CA19-9) in gastric cancer (GC) remains obscure. Therefore, the current study aimed to clarify the clinicopathological value of CA19-9 in GC utilizing autopsy cases. We examined the expression of CA19-9 and mucin core proteins in GC immunohistochemically, and analyzed serum CA19-9 levels and clinicopathological variables or complications. We also investigated whether fucosyltransferases 2 and 3 (FUT2/3) allelic variants influence CA19-9 expression in GC. Compared to GC cases with negative CA19-9 expression (tCA19-9-N), those with positive CA19-9 expression (tCA19-9-P) demonstrated significant differences in characteristic features such as lymph node and distant organ metastases, lymphatic and venous permeation, and higher Tumor, Node, Metastasis (TNM) stages. Moreover, compared to GC cases with low serum CA19-9 levels (sCA19-9-L), those with high serum CA19-9 levels (sCA19-9-H) were related to venous permeation, higher proportion of lymph node and distant organ metastases, and higher TNM stages. Both tCA19-9-P GC and sCA19-9-H GC cases were significantly associated with coagulation abnormalities. sCA19-9-H GC cases correlated significantly with MUC1 and MUC5AC expression. FUT2/3 genotypes were not associated with CA19-9 expression in GC. These results suggest that CA19-9 can predict the risk of lymph node and distant metastases as well as of coagulation abnormalities.
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http://dx.doi.org/10.1111/pin.12882DOI Listing
February 2020

Application of Graphene-Based Materials for Detection of Nitrate and Nitrite in Water-A Review.

Sensors (Basel) 2019 Dec 20;20(1). Epub 2019 Dec 20.

Business school, University of Bedfordshire, Luton LU1 3BE, UK.

Nitrite and nitrate are widely found in various water environments but the potential toxicity of nitrite and nitrate poses a great threat to human health. Recently, many methods have been developed to detect nitrate and nitrite in water. One of them is to use graphene-based materials. Graphene is a two-dimensional carbon nano-material with sp hybrid orbital, which has a large surface area and excellent conductivity and electron transfer ability. It is widely used for modifying electrodes for electrochemical sensors. Graphene based electrochemical sensors have the advantages of being low cost, effective and efficient for nitrite and nitrate detection. This paper reviews the application of graphene-based nanomaterials for electrochemical detection of nitrate and nitrite in water. The properties and advantages of the electrodes were modified by graphene, graphene oxide and reduced graphene oxide nanocomposite in the development of nitrite sensors are discussed in detail. Based on the review, the paper summarizes the working conditions and performance of different sensors, including working potential, pH, detection range, detection limit, sensitivity, reproducibility, repeatability and long-term stability. Furthermore, the challenges and suggestions for future research on the application of graphene-based nanocomposite electrochemical sensors for nitrite detection are also highlighted.
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http://dx.doi.org/10.3390/s20010054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983230PMC
December 2019

Measuring light-induced fungal ethylene production enables non-destructive diagnosis of disease occurrence in harvested fruits.

Food Chem 2020 Apr 7;310:125827. Epub 2019 Nov 7.

School of Life Sciences, East China Normal University, Shanghai 200241, PR China. Electronic address:

Pathogenic fungi cause enormous losses to fruits, and ethylene (ET) is associated with disease development in fruit crops. In this study, ET production of several fungal pathogens was enhanced by light, probably through the free radicals produced by photochemical reactions. Real-time gas analysis showed a sharp increase in ET production when fungal cultures were moved from dark-to-light (DTL). Similarly, light accelerated ET production in the Botrytis cinerea-infected Arabidopsis thaliana plants even when pyrazinamide, the inhibitor for plant ET synthesis, was applied, suggesting that the fungus is responsible for ET production during host invasion. Furthermore, a sharp increase in ET production after DTL transition was observed in B. cinerea-infected tomatoes and grapes, but not in healthy or physically wounded fruits. Taken together, these findings indicate that the DTL-induced ET is specific to the plant materials with fungal infection, and thus represents a candidate marker for non-destructive disease diagnosis of harvested fruits.
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http://dx.doi.org/10.1016/j.foodchem.2019.125827DOI Listing
April 2020

Change of intestinal microbiota in cerebral ischemic stroke patients.

BMC Microbiol 2019 08 19;19(1):191. Epub 2019 Aug 19.

Department of Geriatric Medicine, Qilu Hospital of Shandong University; Key Laboratory of Cardiovascular Proteomics of Shandong Province, Qilu Hospital of Shandong University, Jinan, 250012, China.

Background: Gut microbiota has been suggested to play a role in stroke patients. Nevertheless, little is known about gut microbiota and the clinical indexes in stroke patients.

Methods: Total of 30 cerebral ischemic stroke (CI) patients and 30 healthy control were enrolled in this study and the fecal gut microbiota was profiled via Illumina sequencing of the 16S rRNA V1-V2. The National Institutes of Health Stroke Scale (NIHSS) were used to quantify stroke severity and modified Rankin scale (mRS) to assess outcome for CI patients. The correlations between the clinical indexes and microbiota were evaluated.

Results: Though the microbial α-diversity and structure is similar between CI patients and healthy controls, the gut microbiota of CI patients had more short chain fatty acids producer including Odoribacter, Akkermansia, Ruminococcaceae_UCG_005 and Victivallis. We also found that the special microbes were correlation with serum index, such as norank_O_ _Mollicutes_RF9, Enterobacter, Ruminococcaceae_UCG-002 were negative correlation with LDL (r = - 0.401, P < 0.01), HDL (r = - 0.425, P < 0.01) and blood glucose (r = - 0.439, P < 0.001), while the HDL was significantly positive correlation with the genus Ruminococcus_1 (r = 0.443, P < 0.001). The Christensenellaceae_R-7_group and norank_f_Ruminococcaceae was significantly positive correlation with NIHSS1M (r = 0.514, P < 0.05; r = 0.449, P < 0.05) and mRS (r = 0.471, P < 0.05, r = 0.503, P < 0.01), respectively. On the other hand, the genus Enterobacter was significantly negative correlation with NIHSS1M (r = 0.449, P < 0.05) and mRS (r = 0.503, P < 0.01).

Conclusions: This study suggests that CI patients showed significant dysbiosis of the gut microbiota with enriched short chain fatty acids producer, including Odoribacter, Akkermansia. This dysbiosis was correlation with the outcomes and deserves further study.
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http://dx.doi.org/10.1186/s12866-019-1552-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700817PMC
August 2019

DYRK1A aggravates β cell dysfunction and apoptosis by promoting the phosphorylation and degradation of IRS2.

Exp Gerontol 2019 10 13;125:110659. Epub 2019 Jul 13.

Department of Geriatric Medicine, Qilu Hospital of Shandong University, Jinan, Shandong, China.

In this study, we aimed to investigate the role of dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (DYRK1A), which is one of the most important regulators of Alzheimer's disease development, in islet β cell dysfunction and apoptosis. We found significantly increased expression of DYRK1A in both the hippocampus and pancreatic islets of APP/PS1 transgenic mice than in wild-type littermates. Furthermore, we observed that the overexpression of DYRK1A greatly aggravated β cell apoptosis. Most importantly, we found that DYRK1A directly interacted with insulin receptor substrate-2 (IRS2) and promoted IRS2 phosphorylation, leading to the proteasomal degradation of IRS2 and promotion of β cell dysfunction and apoptosis. These findings suggested that DYRK1A is a potential drug target in diabetes mellitus.
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http://dx.doi.org/10.1016/j.exger.2019.110659DOI Listing
October 2019

Correction to: KRAS status is related to histological phenotype in gastric cancer: results from a large multicentre study.

Gastric Cancer 2019 Nov;22(6):1204-1205

Department of Pathology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center+, P. Debyelaan 25, 6229 HX, Maastricht, The Netherlands.

In the original publication of this article, Fig. 2 was published incorrectly. The correct Fig. 2 is given in this correction.
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http://dx.doi.org/10.1007/s10120-019-00975-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6887891PMC
November 2019

Monitoring the growth of Ag-S clusters through crystallization of intermediate clusters.

Chem Commun (Camb) 2019 Jun;55(47):6771-6774

Collaborative Innovation Center of Chemistry for Energy Materials (iChEM) and State Key Lab of Physical Chemistry of Solid Surfaces, Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, China.

We report a series of Ag-S nanoscale clusters in an attempt to understand the growth process of Ag2S clusters. UV-vis monitoring and crystallization at different stages of the reaction map out the cluster growth steps from Ag31S3(StBu)17(tfa)8(MeCN)4 (tfa = trifluoroacetate), to Ag45S7(StBu)24(tfa)7 to [Ag62S13(StBu)32(tfa)2](tfa)2, showing sequential eye-catching color changes. The cluster growth is associated with the in situ generation of S2-, which comes from the C-S bond cleavage of tert-butyl thiolate.
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http://dx.doi.org/10.1039/c9cc03533hDOI Listing
June 2019

KRAS status is related to histological phenotype in gastric cancer: results from a large multicentre study.

Gastric Cancer 2019 11 20;22(6):1193-1203. Epub 2019 May 20.

Department of Pathology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center+, P. Debyelaan 25, 6229 HX, Maastricht, The Netherlands.

Background: Gastric cancer (GC) is histologically a very heterogeneous disease, and the temporal development of different histological phenotypes remains unclear. Recent studies in lung and ovarian cancer suggest that KRAS activation (KRASact) can influence histological phenotype. KRASact likely results from KRAS mutation (KRASmut) or KRAS amplification (KRASamp). The aim of the study was to investigate whether KRASmut and/or KRASamp are related to the histological phenotype in GC.

Methods: Digitized haematoxylin/eosin-stained slides from 1282 GC resection specimens were classified according to Japanese Gastric Cancer Association (JGCA) and the Lauren classification by at least two observers. The relationship between KRAS status, predominant histological phenotype and clinicopathological variables was assessed.

Results: KRASmut and KRASamp were found in 68 (5%) and 47 (7%) GCs, respectively. Within the KRASmut and KRASamp cases, the most frequent GC histological phenotype was moderately differentiated tubular 2 (tub2) type (KRASmut: n = 27, 40%; KRASamp: n = 21, 46%) or intestinal type (KRASmut: n = 41, 61%; KRASamp: n = 23, 50%). Comparing individual histological subtypes, mucinous carcinoma displayed the highest frequency of KRASmut (JGCA: n = 6, 12%, p = 0.012; Lauren: n = 6, 12%, p = 0.013), and KRASamp was more frequently found in poorly differentiated solid type (n = 12, 10%, p = 0.267) or indeterminate type (n = 12, 10%, p = 0.480) GC. 724 GCs (57%) had intratumour morphological heterogeneity.

Conclusions: This is the largest GC study investigating KRAS status and histological phenotype. We identified a relationship between KRASmut and mucinous phenotype. The high level of intratumour morphological heterogeneity could reflect KRASmut heterogeneity, which may explain the failure of anti-EGFR therapy in GC.
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http://dx.doi.org/10.1007/s10120-019-00972-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6811379PMC
November 2019

The role of repetitive transcranial magnetic stimulation (rTMS) in the treatment of cognitive impairment in patients with Alzheimer's disease: A systematic review and meta-analysis.

J Neurol Sci 2019 Mar 24;398:184-191. Epub 2019 Jan 24.

Department of Gerontology, Qilu Hospital of Shandong University, Jinan 250012, China. Electronic address:

Background: Although repetitive transcranial magnetic stimulation (rTMS) has been considered a potentially effective treatment for cognitive impairment in patients with Alzheimer's disease (AD), previous studies have produced inconsistent results. The objective of this meta-analysis was to evaluate the effects of rTMS on cognitive function in patients with AD.

Methods: PubMed, EMBASE, Web of Science, MEDLINE and Cochrane Central Register of Controlled Trials (CENTRAL) were searched for relevant terms. Abstracts of all papers were carefully reviewed, followed by data extraction, quality assessment, data synthesis and subgroup analyses.

Result: A total of 12 studies with 231 patients were included, with 8 randomized controlled studies and 4 self-controlled studies. Eleven studies used high frequency rTMS (≥ 5 Hz), but only one study directly compared the difference between low-frequency (1 Hz) and high-frequency (20 Hz). Random-effects analysis revealed that rTMS could significantly improve cognition compared with sham-rTMS (SMD: 0.60, 95% CI: 0.35-0.85, P < .0001). In subgroup analyses, the effect for stimulation at a single target was 0.13 (95% CI: -0.35-0.62) and multiple targets 0.86 (95% CI: 0.18-1.54). Treatment for ≤3 sessions produced an effect of 0.29 (95% CI: -1.04-1.62), whereas treatment for ≥5 sessions produced an effect of 2.77 (95% CI: 2.22-3.32). No differences were found for rTMS combined with medication or cognitive training.

Conclusions: rTMS can significantly improve cognitive ability in patients with mild to moderate AD. Stimulation of multiple sites and long-term treatment are better at improving AD-associated cognitive performance. Furthermore, some novel interventional targets, like precuneus (PC), may be a more effective therapeutic site to improve memory in AD.
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http://dx.doi.org/10.1016/j.jns.2019.01.038DOI Listing
March 2019

Toward Long-Term Stability: Single-Crystal Alloys of Cesium-Containing Mixed Cation and Mixed Halide Perovskite.

J Am Chem Soc 2019 Jan 16;141(4):1665-1671. Epub 2019 Jan 16.

State Key Laboratory of Physical Chemistry of Solid Surfaces, Department of Chemistry, College of Chemistry and Chemical Engineering, and Collaborative Innovation Center of Chemistry for Energy Materials , Xiamen University , Xiamen 361005 , China.

Perovskite solar cells are strong competitors for silicon-based ones, but suffer from poor long-term stability, for which the intrinsic stability of perovskite materials is of primary concern. Herein, we prepared a series of well-defined cesium-containing mixed cation and mixed halide perovskite single-crystal alloys, which enabled systematic investigations on their structural stabilities against light, heat, water, and oxygen. Two potential phase separation processes are evidenced for the alloys as the cesium content increases to 10% and/or bromide to 15%. Eventually, a highly stable new composition, (FAPbI)(MAPbBr)(CsPbBr), emerges with a carrier lifetime of 16 μs. It remains stable during at least 10 000 h water-oxygen and 1000 h light stability tests, which is very promising for long-term stable devices with high efficiency. The mechanism for the enhanced stability is elucidated through detailed single-crystal structure analysis. Our work provides a single-crystal-based paradigm for stability investigation, leading to the discovery of stable new perovskite materials.
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http://dx.doi.org/10.1021/jacs.8b11610DOI Listing
January 2019