Tamas L Horvath

Tamas L Horvath

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Tamas L Horvath

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Mitofusin 2 in Mature Adipocytes Controls Adiposity and Body Weight.

Cell Rep 2019 Mar;26(11):2849-2858.e4

Program in Integrative Cell Signaling and Neurobiology of Metabolism, Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA; Department of Anatomy and Histology, University of Veterinary Medicine, Budapest 1078, Hungary. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.02.039DOI Listing
March 2019

Prefrontal Cortical and Behavioral Adaptations to Surgical Delivery Mediated by Metabolic Principles.

Cereb Cortex 2019 Mar 16. Epub 2019 Mar 16.

Program in Integrative Cell Signaling and Neurobiology of Metabolism, Department of Comparative Medicine, Yale School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1093/cercor/bhz046DOI Listing
March 2019

Mitochondrial unfolded protein response: a stress response with implications for fertility and reproductive aging.

Fertil Steril 2019 Feb;111(2):197-204

Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University, New Haven, Connecticut; Program in Integrative Cell Signaling and Neurobiology of Metabolism, Department of Comparative Medicine, New Haven, Connecticut; Department of Neuroscience, Yale School of Medicine, New Haven, Connecticut.

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http://dx.doi.org/10.1016/j.fertnstert.2018.11.048DOI Listing
February 2019

Dopamine neuronal protection in the mouse Substantia nigra by GHSR is independent of electric activity.

Mol Metab 2019 Feb 21. Epub 2019 Feb 21.

Program in Integrative Cell Signaling and Neurobiology of Metabolism, Department of Comparative Medicine, USA; Interdepartmental Neuroscience Program, USA; Department of Obstetrics, Gynecology and Reproductive Sciences, USA; Department of Neuroscience, Yale University School of Medicine, New Haven, CT 06520, USA; Department of Anatomy and Histology, University of Veterinary Medicine, Budapest, 1078, Hungary. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2019.02.005DOI Listing
February 2019

Effects of myeloid sirtuin 1 deficiency on hypothalamic neurogranin in mice fed a high-fat diet.

Biochem Biophys Res Commun 2019 Jan 22;508(1):123-129. Epub 2018 Nov 22.

Department of Anatomy and Convergence Medical Science, Bio Anti-aging Medical Research Center, Institute of Health Sciences, College of Medicine, Gyeongsang National University, Jinju, Gyeongnam, 52777, Republic of Korea. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X183255
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http://dx.doi.org/10.1016/j.bbrc.2018.11.126DOI Listing
January 2019

Role of astrocytes, microglia, and tanycytes in brain control of systemic metabolism.

Nat Neurosci 2019 Jan 10;22(1):7-14. Epub 2018 Dec 10.

Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.

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http://www.nature.com/articles/s41593-018-0286-y
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http://dx.doi.org/10.1038/s41593-018-0286-yDOI Listing
January 2019

The 7q11.23 Protein DNAJC30 Interacts with ATP Synthase and Links Mitochondria to Brain Development.

Cell 2018 Nov;175(4):1088-1104.e23

Department of Neuroscience and Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA; Department of Psychiatry, Yale School of Medicine, New Haven, CT 06510, USA; Departments of Genetics and of Comparative Medicine, Program in Cellular Neuroscience, Neurodegeneration and Repair, and Yale Child Study Center, Yale School of Medicine, New Haven, CT 06510, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.09.014DOI Listing
November 2018

Aromatase and estrogen receptor immunoreactivity in the coronary arteries of monkeys and human subjects.

Menopause 2018 Nov;25(11):1201-1207

Department of Obstetrics and Gynecology and Center for Research in Reproductive Biology, Yale University, New Haven, Connecticut.

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http://dx.doi.org/10.1097/GME.0000000000001219DOI Listing
November 2018

Metabolic regulation and glucose sensitivity of cortical radial glial cells.

Proc Natl Acad Sci U S A 2018 10 17;115(40):10142-10147. Epub 2018 Sep 17.

Department of Neuroscience, Yale School of Medicine, New Haven, CT 06520;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1808066115
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http://dx.doi.org/10.1073/pnas.1808066115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176632PMC
October 2018

Neurophysiological signals as predictive translational biomarkers for Alzheimer's disease treatment: effects of donepezil on neuronal network oscillations in TgF344-AD rats.

Alzheimers Res Ther 2018 Oct 10;10(1):105. Epub 2018 Oct 10.

Translational Neuropharmacology, Department of Comparative Medicine, Yale University School of Medicine, 310 Cedar St, New Haven, CT, 06520, USA.

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http://dx.doi.org/10.1186/s13195-018-0433-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178257PMC
October 2018

Mild Impairment of Mitochondrial OXPHOS Promotes Fatty Acid Utilization in POMC Neurons and Improves Glucose Homeostasis in Obesity.

Cell Rep 2018 Oct;25(2):383-397.e10

Max Planck Institute for Metabolism Research, Department of Neuronal Control of Metabolism, Gleueler Strasse 50, 50931 Cologne, Germany; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne, Kerpener Strasse 26, 50924 Cologne, Germany; Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD) and Center of Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183147
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http://dx.doi.org/10.1016/j.celrep.2018.09.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349418PMC
October 2018

Loss of Nucleobindin-2 Causes Insulin Resistance in Obesity without Impacting Satiety or Adiposity.

Cell Rep 2018 Jul;24(5):1085-1092.e6

Department of Comparative Medicine, Yale School of Medicine, New Haven, CT 06510, USA; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06510, USA; Yale Center for Research on Aging, Yale School of Medicine, New Haven, CT 06510, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.06.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223120PMC
July 2018

Viral Vectors for Studying Brain Mechanisms that Control Energy Homeostasis.

Cell Metab 2018 Jun;27(6):1168-1175

Program in Integrative Cell Signalling and Neurobiology of Metabolism, Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA; Department of Anatomy and Histology, University of Veterinary Medicine, Budapest 1078, Hungary. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.05.015DOI Listing
June 2018

Altered Cortical and Hippocampal Excitability in TgF344-AD Rats Modeling Alzheimer's Disease Pathology.

Cereb Cortex 2018 Jun 16. Epub 2018 Jun 16.

Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1093/cercor/bhy140DOI Listing
June 2018

Brown adipose tissue derived ANGPTL4 controls glucose and lipid metabolism and regulates thermogenesis.

Mol Metab 2018 05 29;11:59-69. Epub 2018 Mar 29.

Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, USA; Integrative Cell Signaling and Neurobiology of Metabolism Program, Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2018.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001401PMC
May 2018

Myeloid sirtuin1 deficiency aggravates hippocampal inflammation in mice fed high-fat diets.

Biochem Biophys Res Commun 2018 05 10;499(4):1025-1031. Epub 2018 Apr 10.

Department of Anatomy and Convergence Medical Science, Bio Anti-aging Medical Research Center, Institute of Health Sciences, College of Medicine, Gyeongsang National University, Jinju, Gyeongnam 52727, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2018.04.044DOI Listing
May 2018

Patient-Derived iPSC-Hypothamic Neurons: The Ultimate Protocol.

Cell Stem Cell 2018 May;22(5):615-616

Program in Integrative Cell Signaling and Neurobiology of Metabolism, Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA; Department of Anatomy and Histology, University of Veterinary Medicine, Budapest 1078, Hungary. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2018.04.019DOI Listing
May 2018

Comparative Analysis of Zearalenone Effects on Thyroid Receptor Alpha (TRα) and Beta (TRβ) Expression in Rat Primary Cerebellar Cell Cultures.

Int J Mol Sci 2018 May 11;19(5). Epub 2018 May 11.

Department of Animal Physiology and Animal Health, Faculty of Agricultural and Environmental Sciences, Szent István University, Páter Károly u. 1, H-2100 Gödöllő, Hungary.

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http://dx.doi.org/10.3390/ijms19051440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983839PMC
May 2018

Neuronal Cilia: Another Player in the Melanocortin System.

Trends Mol Med 2018 04 28;24(4):333-334. Epub 2018 Feb 28.

Program in Integrative Cell Signaling and Neurobiology of Metabolism, Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA; Department of Anatomy and Histology, University of Veterinary Medicine, Budapest, 1078 Hungary. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2018.02.004DOI Listing
April 2018

From white to beige: a new hypothalamic pathway.

EMBO Rep 2018 04 26;19(4). Epub 2018 Mar 26.

Department of Comparative Medicine, Program in Integrative Cell Signalling and Neurobiology of Metabolism, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.15252/embr.201845928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891399PMC
April 2018

Thyroid hormone- and estrogen receptor interactions with natural ligands and endocrine disruptors in the cerebellum.

Front Neuroendocrinol 2018 01 5;48:23-36. Epub 2017 Oct 5.

Department of Animal Physiology and Animal Health, Faculty of Agricultural and Environmental Sciences, Szent István University, Páter Károly u. 1, H-2100 Gödöllő, Hungary; Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA; Departments of Anatomy and Histology, University of Veterinary Medicine, Budapest 1078, Hungary. Electronic address:

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http://dx.doi.org/10.1016/j.yfrne.2017.10.001DOI Listing
January 2018

Ghrelin is Related to Personality Differences in Reward Sensitivity and Impulsivity.

Alcohol Alcohol 2018 Jan;53(1):52-56

Department of Psychiatry, Yale University School of Medicine, 333 Cedar St., New Haven, CT.

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http://dx.doi.org/10.1093/alcalc/agx082DOI Listing
January 2018

Cannabis in fat: high hopes to treat obesity.

J Clin Invest 2017 Nov 16;127(11):3918-3920. Epub 2017 Oct 16.

Yale University School of Medicine, and.

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http://dx.doi.org/10.1172/JCI97042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663345PMC
November 2017

Comparative Medicine: An Inclusive Crossover Discipline.

Yale J Biol Med 2017 09 25;90(3):493-498. Epub 2017 Sep 25.

Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612191PMC
September 2017

Plasticity of calcium-permeable AMPA glutamate receptors in Pro-opiomelanocortin neurons.

Elife 2017 08 1;6. Epub 2017 Aug 1.

Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, United States.

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http://dx.doi.org/10.7554/eLife.25755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538821PMC
August 2017

Ghrelin is Supressed by Intravenous Alcohol and is Related to Stimulant and Sedative Effects of Alcohol.

Alcohol Alcohol 2017 Jul;52(4):431-438

Department of Psychiatry, Yale University School of Medicine, 333 Cedar St., New Haven, CT, USA.

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http://dx.doi.org/10.1093/alcalc/agx022DOI Listing
July 2017

Endothelial HIF-1α Enables Hypothalamic Glucose Uptake to Drive POMC Neurons.

Diabetes 2017 06 14;66(6):1511-1520. Epub 2017 Mar 14.

Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT

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http://dx.doi.org/10.2337/db16-1106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440016PMC
June 2017

Fetal Growth Restriction Caused by Sexual Transmission of Zika Virus in Mice.

J Infect Dis 2017 06;215(11):1720-1724

Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine.

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https://academic.oup.com/jid/article/215/11/1720/3786455
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http://dx.doi.org/10.1093/infdis/jix204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5853330PMC
June 2017

Mitochondria Bioenergetic and Cognitive Functions: The Cannabinoid Link.

Trends Cell Biol 2017 06 6;27(6):391-392. Epub 2017 May 6.

Program in Integrative Cell Signalling and Neurobiology of Metabolism, Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA; Department of Anatomy and Histology, University of Veterinary Medicine, Budapest 1078, Hungary. Electronic address:

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http://dx.doi.org/10.1016/j.tcb.2017.04.003DOI Listing
June 2017

Mitochondrial Dynamics Mediated by Mitofusin 1 Is Required for POMC Neuron Glucose-Sensing and Insulin Release Control.

Cell Metab 2017 Jun;25(6):1390-1399.e6

Neuronal Control of Metabolism (NeuCoMe) Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain; CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), 08036 Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.05.010DOI Listing
June 2017

Microglial Proliferation in Obesity: When, Where, Why, and What Does It Mean?

Diabetes 2017 04;66(4):804-805

Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Instituto de Investigación del Hospital de la Princesa, Centro de Investigación Biomédica en Red de Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain.

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http://dx.doi.org/10.2337/dbi16-0073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5360305PMC
April 2017

Cannabinoid type 1 receptor-containing axons innervate NPY/AgRP neurons in the mouse arcuate nucleus.

Mol Metab 2017 04 27;6(4):374-381. Epub 2017 Jan 27.

Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, 06520 New Haven, CT, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22128778163027
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http://dx.doi.org/10.1016/j.molmet.2017.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5369208PMC
April 2017

(S)Pot on Mitochondria: Cannabinoids Disrupt Cellular Respiration to Limit Neuronal Activity.

Cell Metab 2017 01;25(1):8-10

Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06510, USA.

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http://dx.doi.org/10.1016/j.cmet.2016.12.020DOI Listing
January 2017

Bisphenol A influences oestrogen- and thyroid hormone-regulated thyroid hormone receptor expression in rat cerebellar cell culture.

Acta Vet Hung 2016 12;64(4):497-513

Department of Animal Physiology and Animal Health, Faculty of Agricultural and Environmental Sciences, Szent István University , Páter Károly u. 1, H-2100 Gödöllő , Hungary.

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http://dx.doi.org/10.1556/004.2016.046DOI Listing
December 2016

HSV-2 enhances ZIKV infection of the placenta and induces apoptosis in first-trimester trophoblast cells.

Am J Reprod Immunol 2016 11 10;76(5):348-357. Epub 2016 Sep 10.

Division of Reproductive Sciences, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1111/aji.12578DOI Listing
November 2016

The role of astrocytes in the hypothalamic response and adaptation to metabolic signals.

Prog Neurobiol 2016 09 18;144:68-87. Epub 2016 Mar 18.

Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Instituto de Investigación la Princesa, CIBER de Obesidad Fisiopatología de la Obesidad y Nutrición (CIBEROBN). Instituto de Salud Carlos III, Madrid, Spain; Department of Pediatrics, Universidad Autónoma de Madrid, Madrid, Spain.

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http://dx.doi.org/10.1016/j.pneurobio.2016.03.001DOI Listing
September 2016

Zika Virus Disrupts Phospho-TBK1 Localization and Mitosis in Human Neuroepithelial Stem Cells and Radial Glia.

Cell Rep 2016 09 24;16(10):2576-2592. Epub 2016 Aug 24.

Department of Neuroscience and Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA; Cellular Neuroscience, Neurodegeneration and Repair Program, Departments of Neurology and Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA; Section of Comparative Medicine, Yale School of Medicine, New Haven, CT 06510, USA; Departments of Genetics and Psychiatry, Yale School of Medicine, New Haven, CT 06510, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.08.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135012PMC
September 2016

Feeding Behavior: Hypocretin/Orexin Neurons Act between Food Seeking and Eating.

Curr Biol 2016 09;26(18):R845-R847

Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06511, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2016.07.069DOI Listing
September 2016

Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability.

Cell 2016 Aug;166(4):867-880

Helmholtz Diabetes Center (HDC) & German Center for Diabetes Research (DZD), Helmholtz Zentrum München, 85764 Neuherberg, Germany; Division of Metabolic Diseases, Technische Universität München, 80333 Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.07.028DOI Listing
August 2016

Vaginal Exposure to Zika Virus during Pregnancy Leads to Fetal Brain Infection.

Cell 2016 Aug;166(5):1247-1256.e4

Department of Immunobiology, Yale University School of Medicine, New Haven, CT, 06520 USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT, 06520 USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006689PMC
August 2016

Hypothalamic TLR2 triggers sickness behavior via a microglia-neuronal axis.

Sci Rep 2016 07 12;6:29424. Epub 2016 Jul 12.

Department of Biological Sciences, University of Ulsan, Ulsan, 680-749, Republic of Korea.

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http://dx.doi.org/10.1038/srep29424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942617PMC
July 2016

Mitochondria controlled by UCP2 determine hypoxia-induced synaptic remodeling in the cortex and hippocampus.

Neurobiol Dis 2016 Jun 9;90:68-74. Epub 2016 Jan 9.

Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA; Department of Neuroscience at Yale Medical School, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2016.01.004DOI Listing
June 2016

Role of mitochondrial uncoupling protein-2 (UCP2) in higher brain functions, neuronal plasticity and network oscillation.

Mol Metab 2016 Jun 9;5(6):415-421. Epub 2016 Apr 9.

Yale School of Medicine, Section of Comparative Medicine, 310 Cedar St., BML 330, P.O. Box 208016, New Haven, CT 06520-8016, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2016.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877662PMC
June 2016

Viral Spread to Enteric Neurons Links Genital HSV-1 Infection to Toxic Megacolon and Lethality.

Cell Host Microbe 2016 Jun;19(6):788-99

Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address:

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http://www.cell.com/cell-host-microbe/pdf/S1931-3128(16)3020
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http://linkinghub.elsevier.com/retrieve/pii/S193131281630204
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http://dx.doi.org/10.1016/j.chom.2016.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902295PMC
June 2016

Estrogen- and Satiety State-Dependent Metabolic Lateralization in the Hypothalamus of Female Rats.

PLoS One 2015 4;10(9):e0137462. Epub 2015 Sep 4.

Division of Comparative Medicine, Yale University School of Medicine, New Haven, CT, United States of America; Department of Animal Physiology and Animal Health, Szent Istvan University Faculty of Agricultural and Environmental Sciences, Godollo, Hungary.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0137462PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560379PMC
May 2016

Mitochondrial Uncoupling Protein 2 (UCP2) Regulates Retinal Ganglion Cell Number and Survival.

J Mol Neurosci 2016 Apr 5;58(4):461-9. Epub 2016 Feb 5.

Department of Neurobiology, Yale University School of Medicine, New Haven, CT, 06510, USA.

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http://dx.doi.org/10.1007/s12031-016-0728-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833669PMC
April 2016

Reducing Adiposity in a Critical Developmental Window Has Lasting Benefits in Mice.

Endocrinology 2016 Feb 20;157(2):666-78. Epub 2015 Nov 20.

Institute of Human Nutrition (J.S.L., A.C.N.N.), Columbia University, New York, New York 10032; Department of Anesthesiology (L.E.R.), Columbia University, New York, New York 10032; Naomi Berrie Diabetes Center (R.H., L.M.Z.), Columbia University, New York, New York 10032; Department of Obstetrics, Gynecology, and Reproductive Sciences (K.S.-B., T.L.H.), Yale University School of Medicine, New Haven, Connecticut 06510; Department of Neurobiology (T.L.H.), Yale University School of Medicine, New Haven, Connecticut 06510; and Department of Pathology and Cell Biology (L.M.Z.), Columbia University, New York, New York 10032.

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http://dx.doi.org/10.1210/en.2015-1753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4733128PMC
February 2016

Metabolism and Mental Illness.

Trends Mol Med 2016 Feb 14;22(2):174-183. Epub 2016 Jan 14.

Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14714914150023
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http://dx.doi.org/10.1016/j.molmed.2015.12.003DOI Listing
February 2016

Synaptic lipids in cortical function and psychiatric disorders.

EMBO Mol Med 2016 Jan;8(1):3-5

Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA.

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http://embomolmed.embopress.org/cgi/doi/10.15252/emmm.201505
Publisher Site
http://dx.doi.org/10.15252/emmm.201505749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718156PMC
January 2016

Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involution.

Proc Natl Acad Sci U S A 2016 Jan 11;113(4):1026-31. Epub 2016 Jan 11.

Section of Comparative Medicine and Program on Integrative Cell Signaling and Neurobiology of Metabolism, Yale School of Medicine, New Haven, CT 06520; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520

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http://dx.doi.org/10.1073/pnas.1514511113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743827PMC
January 2016

Neuronal Regulation of Energy Homeostasis: Beyond the Hypothalamus and Feeding.

Cell Metab 2015 Dec 22;22(6):962-70. Epub 2015 Oct 22.

Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2015.09.026DOI Listing
December 2015

Developmental programming of hypothalamic neuroendocrine systems.

Front Neuroendocrinol 2015 Oct 21;39:52-8. Epub 2015 Sep 21.

Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06510, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yfrne.2015.09.002DOI Listing
October 2015

AgRP Neurons Regulate Bone Mass.

Cell Rep 2015 Oct 24;13(1):8-14. Epub 2015 Sep 24.

Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.08.070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868421PMC
October 2015

Mitochondrial ROS signaling in organismal homeostasis.

Cell 2015 Oct 22;163(3):560-9. Epub 2015 Oct 22.

Program in Integrative Cell Signaling and Neurobiology of Metabolism, Yale School of Medicine, New Haven CT 06520; Section of Comparative Medicine, Yale School of Medicine, New Haven CT 06520; Department of Neurobiology, Yale School of Medicine, New Haven CT 06520. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634671PMC
October 2015

A sympathetic view on fat by leptin.

Cell 2015 Sep;163(1):26-7

Program in Integrative Cell Signalling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.09.016DOI Listing
September 2015

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease.

Nat Med 2015 Mar 16;21(3):263-9. Epub 2015 Feb 16.

1] Section of Comparative Medicine and Program on Integrative Cell Signaling and Neurobiology of Metabolism, Yale School of Medicine, New Haven, Connecticut, USA. [2] Department of Immunobiology, Yale School of Medicine, New Haven, Connecticut, USA.

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http://www.nature.com/articles/nm.3804
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352123PMC
March 2015

Hypothalamic POMC neurons promote cannabinoid-induced feeding.

Nature 2015 Mar 18;519(7541):45-50. Epub 2015 Feb 18.

1] Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA [2] Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA [3] Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA [4] Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, Connecticut 06520, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496586PMC
March 2015

Hypothalamic Agrp neurons drive stereotypic behaviors beyond feeding.

Cell 2015 Mar 5;160(6):1222-32. Epub 2015 Mar 5.

Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA; Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06520, USA; Kavli Institute for Neuroscience at Yale University, New Haven, CT 06520, USA.

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http://dx.doi.org/10.1016/j.cell.2015.02.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484787PMC
March 2015

Hypothalamic sidedness in mitochondrial metabolism: new perspectives.

Reprod Sci 2014 Dec 16;21(12):1492-8. Epub 2014 Apr 16.

Department of Physiology and Biochemistry, Szent Istvan University Faculty of Veterinary Sciences, Budapest, Hungary

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http://dx.doi.org/10.1177/1933719114530188DOI Listing
December 2014

Mitochondrial dynamics in the central regulation of metabolism.

Nat Rev Endocrinol 2014 Nov 9;10(11):650-8. Epub 2014 Sep 9.

Program in Integrative Cell Signalling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, SHM L-200, PO Box 208074, New Haven, CT 06520-8074, USA.

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November 2014

O-GlcNAc transferase enables AgRP neurons to suppress browning of white fat.

Cell 2014 Oct;159(2):306-17

Program in Integrative Cell Signaling and Neurobiology of Metabolism, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA; Section of Comparative Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA; Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509746PMC
October 2014

Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding.

Nat Neurosci 2014 Jul 1;17(7):908-10. Epub 2014 Jun 1.

1] Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut, USA. [2] Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, USA. [3] Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut, USA.

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http://dx.doi.org/10.1038/nn.3725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113214PMC
July 2014

Minireview: Metabolism of female reproduction: regulatory mechanisms and clinical implications.

Mol Endocrinol 2014 Jun 28;28(6):790-804. Epub 2014 Mar 28.

Department of Obstetrics, Gynecology, and Reproductive Sciences (E.S., E.B., S.C., T.L.H.), Yale School of Medicine, New Haven, Connecticut 06520; Department of Obstetrics and Gynecology (G.N., T.L.H.), University of Szeged, Faculty of Medicine, Szeged, Hungary 6701; Department of Comparative Medicine (T.L.H.), Yale School of Medicine, New Haven, Connecticut 06520; and the Department of Neurobiology (T.L.H.), Yale School of Medicine, New Haven, Connecticut 06520.

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http://dx.doi.org/10.1210/me.2013-1413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042071PMC
June 2014

A temperature hypothesis of hypothalamus-driven obesity.

Yale J Biol Med 2014 Jun 6;87(2):149-58. Epub 2014 Jun 6.

Yale Program in Cell Signaling and Neurobiology of Metabolism, Yale School of Medicine, New Haven, Connecticut ; Section of Comparative Medicine, Yale School of Medicine, New Haven, Connecticut ; Department of Neurobiology, Yale School of Medicine, New Haven, Connecticut ; Departments of Ob/Gyn and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031788PMC
June 2014

Role of synaptic plasticity and EphA5-ephrinA5 interaction within the ventromedial hypothalamus in response to recurrent hypoglycemia.

Diabetes 2014 Mar 12;63(3):1140-7. Epub 2013 Nov 12.

Yale University School of Medicine, Department of Internal Medicine and Endocrinology, New Haven, CT.

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http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db13-12
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http://dx.doi.org/10.2337/db13-1259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931406PMC
March 2014

Neonatal insulin action impairs hypothalamic neurocircuit formation in response to maternal high-fat feeding.

Cell 2014 Jan 23;156(3):495-509. Epub 2014 Jan 23.

Max Planck Institute for Neurological Research, 50931 Cologne, Germany; Department of Mouse Genetics and Metabolism, Institute for Genetics, University of Cologne, 50674 Cologne, Germany; Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD) and Center of Molecular Medicine Cologne (CMMC), University of Cologne, 50674 Cologne, Germany; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne, 50924 Cologne, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.01.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101521PMC
January 2014

Natural birth-induced UCP2 in brain development.

Rev Endocr Metab Disord 2013 Dec;14(4):347-50

Department of Ob/Gyn and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, 06520, USA.

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December 2013

UCP2 overexpression worsens mitochondrial dysfunction and accelerates disease progression in a mouse model of amyotrophic lateral sclerosis.

Mol Cell Neurosci 2013 Nov 17;57:104-10. Epub 2013 Oct 17.

Brain and Mind Research Institute, Weill Cornell Medical College, 407 East 61st St, New York, NY 10065, USA; Department of Natural Sciences, Baruch College, City University of New York (CUNY), 17 Lexington Avenue, New York, NY 10010, USA.

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http://dx.doi.org/10.1016/j.mcn.2013.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891658PMC
November 2013

Uncovering novel roles of nonneuronal cells in body weight homeostasis and obesity.

Endocrinology 2013 Sep 24;154(9):3001-7. Epub 2013 Jun 24.

Hospital Infantil Universitario Niño Jesús, Department of Endocrinology, Instituto de Investigación La Princesa, 28009 Madrid, Spain.

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http://dx.doi.org/10.1210/en.2013-1303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749483PMC
September 2013

Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance.

Cell 2013 Sep;155(1):172-87

Diabetes and Obesity Research Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain; Department of Endocrinology and Nutrition, Hospital Clínic. School of Medicine, University of Barcelona, 08036 Barcelona, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), 08036 Barcelona, Spain.

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http://dx.doi.org/10.1016/j.cell.2013.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839088PMC
September 2013

Mitochondrial dynamics controlled by mitofusins regulate Agrp neuronal activity and diet-induced obesity.

Cell 2013 Sep;155(1):188-99

Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA; Department of Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS 90035, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2013.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142434PMC
September 2013

Antibodies to cannabinoid type 1 receptor co-react with stomatin-like protein 2 in mouse brain mitochondria.

Eur J Neurosci 2013 Aug 26;38(3):2341-8. Epub 2013 Apr 26.

Department of Neurobiology, Yale University School of Medicine and Kavli Institute for Neuroscience, New Haven, CT, USA.

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http://dx.doi.org/10.1111/ejn.12237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902808PMC
August 2013

Role of uncoupling protein 3 in ischemia-reperfusion injury, arrhythmias, and preconditioning.

Am J Physiol Heart Circ Physiol 2013 May 1;304(9):H1192-200. Epub 2013 Mar 1.

Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.

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http://www.physiology.org/doi/10.1152/ajpheart.00592.2012
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652089PMC
May 2013

Hunger-promoting hypothalamic neurons modulate effector and regulatory T-cell responses.

Proc Natl Acad Sci U S A 2013 Apr 25;110(15):6193-8. Epub 2013 Mar 25.

Dipartimento di Medicina e Chirurgia, Università degli Studi di Salerno, 84081 Salerno, Italy.

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http://dx.doi.org/10.1073/pnas.1210644110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625304PMC
April 2013

Hypothalamic control of energy balance: insights into the role of synaptic plasticity.

Trends Neurosci 2013 Feb 12;36(2):65-73. Epub 2013 Jan 12.

Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S01662236120022
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http://dx.doi.org/10.1016/j.tins.2012.12.005DOI Listing
February 2013

Leptin and insulin pathways in POMC and AgRP neurons that modulate energy balance and glucose homeostasis.

EMBO Rep 2012 Dec 13;13(12):1079-86. Epub 2012 Nov 13.

Program in Integrative Cell Signalling & Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA.

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http://embor.embopress.org/cgi/doi/10.1038/embor.2012.174
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3512417PMC
December 2012

A marriage made to last in drug design.

Nat Med 2012 Dec;18(12):1737-8

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December 2012

Ghrelin and the central regulation of feeding and energy balance.

Indian J Endocrinol Metab 2012 Dec;16(Suppl 3):S617-26

Department of Neuroscience, Carlton University, Ottawa, ON, Canada.

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http://dx.doi.org/10.4103/2230-8210.105580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602992PMC
December 2012

AgRP neurons: a switch between peripheral carbohydrate and lipid utilization.

EMBO J 2012 Nov 19;31(22):4252-4. Epub 2012 Oct 19.

Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA.

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http://emboj.embopress.org/cgi/doi/10.1038/emboj.2012.287
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501218PMC
November 2012

Phosphoribosomes for fingerprinting neurons.

Cell 2012 Nov;151(5):934-6

Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.

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November 2012