Publications by authors named "Tamara L Lotan"

100Publications

The Mutational Landscape of Metastatic Castration-sensitive Prostate Cancer: The Spectrum Theory Revisited.

Eur Urol 2021 Jan 5. Epub 2021 Jan 5.

Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA; James Buchanan Brady Urological Institute, Johns Hopkins School of Medicine, Baltimore, MD, USA. Electronic address:

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January 2021

Deficiency and the Immune Microenvironment in Prostate Cancer.

Clin Cancer Res 2020 Nov 16. Epub 2020 Nov 16.

Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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November 2020

PIN-like ductal carcinoma of the prostate has frequent activating RAS/RAF mutations.

Histopathology 2021 Jan 24;78(2):327-333. Epub 2020 Sep 24.

Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA.

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January 2021

Emerging Subtypes and New Treatments for Castration-Resistant Prostate Cancer.

Am Soc Clin Oncol Educ Book 2020 May;40:e319-e332

University of California, San Francisco, CA.

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May 2020

Telomere lengths differ significantly between small-cell neuroendocrine prostate carcinoma and adenocarcinoma of the prostate.

Hum Pathol 2020 Jul 7;101:70-79. Epub 2020 May 7.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA; Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, 21287, USA.

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July 2020

Rare Germline Pathogenic Mutations of DNA Repair Genes Are Most Strongly Associated with Grade Group 5 Prostate Cancer.

Eur Urol Oncol 2020 04 14;3(2):224-230. Epub 2020 Jan 14.

Department of Urology and the James Buchanan Brady Urologic Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD, USA. Electronic address:

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April 2020

High Extratumoral Mast Cell Counts Are Associated with a Higher Risk of Adverse Prostate Cancer Outcomes.

Cancer Epidemiol Biomarkers Prev 2020 03 13;29(3):668-675. Epub 2020 Jan 13.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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March 2020

Germline BLM mutations and metastatic prostate cancer.

Prostate 2020 02 5;80(2):235-237. Epub 2019 Nov 5.

Tulane Cancer Center, New Orleans, Louisiana.

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February 2020

Genomic and clinical characterization of pulmonary-only metastatic prostate cancer: A unique molecular subtype.

Prostate 2019 09 7;79(13):1572-1579. Epub 2019 Aug 7.

Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, Maryland.

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September 2019

Pan-Cancer Analysis of Loss-of-Function Alterations and Their Association with the Focal Tandem-Duplicator Phenotype.

Oncologist 2019 12 10;24(12):1526-1533. Epub 2019 Jul 10.

Johns Hopkins University School of Medicine and Bloomberg-Kimmel Institute for Cancer Immunotherapy, Baltimore, Maryland, USA

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December 2019

Mannose Receptor-positive Macrophage Infiltration Correlates with Prostate Cancer Onset and Metastatic Castration-resistant Disease.

Eur Urol Oncol 2019 07 19;2(4):429-436. Epub 2018 Oct 19.

Department of Oncology, Johns Hopkins School of Medicine and The Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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July 2019

TP53 missense mutation is associated with increased tumor-infiltrating T cells in primary prostate cancer.

Hum Pathol 2019 05 6;87:95-102. Epub 2019 Mar 6.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

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May 2019

SPINK1 expression is enriched in African American prostate cancer but is not associated with altered immune infiltration or oncologic outcomes post-prostatectomy.

Prostate Cancer Prostatic Dis 2019 12 8;22(4):552-559. Epub 2019 Mar 8.

Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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December 2019

DNA damage repair alterations are frequent in prostatic adenocarcinomas with focal pleomorphic giant-cell features.

Histopathology 2019 May 1;74(6):836-843. Epub 2019 Apr 1.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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May 2019

Clinical Features and Therapeutic Outcomes in Men with Advanced Prostate Cancer and DNA Mismatch Repair Gene Mutations.

Eur Urol 2019 03 15;75(3):378-382. Epub 2018 Oct 15.

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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March 2019

Effect of Preanalytic Variables on an Automated PTEN Immunohistochemistry Assay for Prostate Cancer.

Arch Pathol Lab Med 2019 03 8;143(3):338-348. Epub 2018 Oct 8.

From the Departments of Pathology (Drs Guedes, Morais, Fedor, Hicks, Gurel, De Marzo, and Lotan), Oncology (Drs Trock, De Marzo, and Lotan), and Urology (Drs Trock and De Marzo), Johns Hopkins University School of Medicine, Baltimore, Maryland; the Department of Pathology, New York University School of Medicine, New York, New York (Drs Melamed and Lee); the Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York (Drs Gopalan and Fine); the Department of Pathology, Cedars-Sinai Medical Center, Los Angeles, California (Dr Knudsen); the Department of Pathology, University of Washington, Seattle (Dr True); and Genitourinary Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, New York (Dr Scher).

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March 2019

PTEN status assessment in the Johns Hopkins active surveillance cohort.

Prostate Cancer Prostatic Dis 2019 03 2;22(1):176-181. Epub 2018 Oct 2.

Department of Urology, Johns Hopkins School of Medicine, Baltimore, MD, USA.

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March 2019

Detection of AR-V7 transcript with RNA in situ hybridization in human salivary duct cancer.

Oral Oncol 2018 09 28;84:134-136. Epub 2018 Jun 28.

Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States; Department of Urology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States; Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.

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September 2018

Prostatic Adenocarcinoma With Focal Pleomorphic Giant Cell Features: A Series of 30 Cases.

Am J Surg Pathol 2018 10;42(10):1286-1296

Department of Pathology, Johns Hopkins Medical Institute, Baltimore, MD.

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October 2018

The Androgen Signaling Axis and Risk Stratification for High-grade Prostate Cancer.

Eur Urol 2018 08 26;74(2):155-156. Epub 2018 Mar 26.

Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA; Department of Oncology, Johns Hopkins School of Medicine, Baltimore, MD, USA.

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August 2018

Comprehensive Evaluation of Programmed Death-Ligand 1 Expression in Primary and Metastatic Prostate Cancer.

Am J Pathol 2018 06 22;188(6):1478-1485. Epub 2018 Mar 22.

Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins School of Medicine, Baltimore, Maryland; Department of Pathology, The Johns Hopkins School of Medicine, Baltimore, Maryland; Brady Urological Institute, The Johns Hopkins School of Medicine, Baltimore, Maryland. Electronic address:

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June 2018

A phase II study of the dual mTOR inhibitor MLN0128 in patients with metastatic castration resistant prostate cancer.

Invest New Drugs 2018 06 6;36(3):458-467. Epub 2018 Mar 6.

Genitourinary Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.

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June 2018

Clinical implications of PTEN loss in prostate cancer.

Nat Rev Urol 2018 04 20;15(4):222-234. Epub 2018 Feb 20.

Department of Pathology, Johns Hopkins University, Baltimore, MD, USA.

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April 2018

Gene expression signatures of neuroendocrine prostate cancer and primary small cell prostatic carcinoma.

BMC Cancer 2017 Nov 13;17(1):759. Epub 2017 Nov 13.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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November 2017

Comprehensive Determination of Prostate Tumor ETS Gene Status in Clinical Samples Using the CLIA Decipher Assay.

J Mol Diagn 2017 05 21;19(3):475-484. Epub 2017 Mar 21.

Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland; Department of Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland. Electronic address:

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May 2017

Implementation of a Surgeon-Level Comparative Quality Performance Review to Improve Positive Surgical Margin Rates during Radical Prostatectomy.

J Urol 2017 05 1;197(5):1245-1250. Epub 2016 Dec 1.

Department of Urology, Northwestern University Feinberg School of Medicine (RSM, EMS), Chicago, Illinois; The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, Baltimore, Maryland. Electronic address:

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May 2017

Correlation of PSMA-Targeted F-DCFPyL PET/CT Findings With Immunohistochemical and Genomic Data in a Patient With Metastatic Neuroendocrine Prostate Cancer.

Clin Genitourin Cancer 2017 02 19;15(1):e65-e68. Epub 2016 Sep 19.

The James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD.

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February 2017

PTEN Loss in Gleason Score 3 + 4 = 7 Prostate Biopsies is Associated with Nonorgan Confined Disease at Radical Prostatectomy.

J Urol 2017 04 28;197(4):1054-1059. Epub 2016 Sep 28.

Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address:

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April 2017

Prevalence and Prognostic Significance of PTEN Loss in African-American and European-American Men Undergoing Radical Prostatectomy.

Eur Urol 2017 05 28;71(5):697-700. Epub 2016 Jul 28.

Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA; Department of Oncology, Johns Hopkins School of Medicine, Baltimore, MD, USA. Electronic address:

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May 2017

Elevated Prostate Health Index (phi) and Biopsy Reclassification During Active Surveillance of Prostate Cancer.

Urol Case Rep 2016 Jul 26;7:64-6. Epub 2016 May 26.

The James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

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July 2016

ERG and PTEN status of isolated high-grade PIN occurring in cystoprostatectomy specimens without invasive prostatic adenocarcinoma.

Hum Pathol 2016 09 14;55:117-25. Epub 2016 May 14.

Pathology, Johns Hopkins School of Medicine, Baltimore, MD 21231; Oncology, Johns Hopkins School of Medicine, Baltimore, MD 21231. Electronic address:

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September 2016

Analytic Validation of RNA In Situ Hybridization (RISH) for AR and AR-V7 Expression in Human Prostate Cancer.

Clin Cancer Res 2016 Sep 10;22(18):4651-63. Epub 2016 May 10.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland. Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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September 2016

Premalignancy in Prostate Cancer: Rethinking What we Know.

Cancer Prev Res (Phila) 2016 Aug 26;9(8):648-56. Epub 2016 Jan 26.

Departments of Pathology Oncology Urology The Johns Hopkins University School of Medicine, The Sidney Kimmel Comprehensive Cancer Center The Brady Urological Research Institute at Johns Hopkins, Johns Hopkins University, Baltimore, MD.

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August 2016

A Prospective Investigation of PTEN Loss and ERG Expression in Lethal Prostate Cancer.

J Natl Cancer Inst 2016 Feb 27;108(2). Epub 2015 Nov 27.

Department of Epidemiology (TUA, AP, EME, TG, REG, KMW, JRR, HDS, ELG, MJS, LAM) and Department of Nutrition (ELG, MJS), Harvard T. H. Chan School of Public Health, Boston, MA; Clinical Epidemiology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden (AP); Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA (REG); Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD (CLM, JLH, AMDM, TLL); Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (JRR, ELG, MJS, LAM, KMW); Divisions of Preventive Medicine and Aging, Department of Medicine, Brigham and Women's Hospital, Boston, MA (HDS); Pathology Unit, Addarii Institute, S. Orsola-Malpighi Hospital, Bologna, Italy (MF); Department of Histopathology Research, Trinity College, Dublin, Ireland (RF, SF); Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA (ML); Department of Oncology (AMDM, TLL) and Department of Urology (ADMD), Johns Hopkins University School of Medicine, Baltimore, MD.

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February 2016

The Placental Gene PEG10 Promotes Progression of Neuroendocrine Prostate Cancer.

Cell Rep 2015 Aug 30;12(6):922-36. Epub 2015 Jul 30.

Vancouver Prostate Centre, University of British Columbia, Vancouver, BC V6H 3Z6, Canada; Department of Urologic Sciences, University of British Columbia, Vancouver, BC V6H 3Z6, Canada. Electronic address:

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August 2015

Overlap of CD44 expression between prostatic small cell carcinoma and acinar adenocarcinoma.

Hum Pathol 2015 Apr 31;46(4):554-7. Epub 2014 Dec 31.

Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD, United States 21231; Department of Urology, The Johns Hopkins Hospital, Baltimore, MD, United States 21231; Department of Oncology, The Johns Hopkins Hospital, Baltimore, MD, United States 21231. Electronic address:

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April 2015

Utility of PTEN and ERG immunostaining for distinguishing high-grade PIN from intraductal carcinoma of the prostate on needle biopsy.

Am J Surg Pathol 2015 Feb;39(2):169-78

Departments of *Pathology ∥Oncology ¶Urology, Johns Hopkins Medical Institutions, Baltimore, MD †Division of Pathology, Integrated Medical Professionals, PLLC., Garden City, NY ‡Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH §Miraca Life Sciences, Irving, TX.

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February 2015

Prostate adenocarcinomas aberrantly expressing p63 are molecularly distinct from usual-type prostatic adenocarcinomas.

Mod Pathol 2015 Mar 12;28(3):446-56. Epub 2014 Sep 12.

1] Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA [2] Department of Oncology and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD, USA.

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March 2015

AR-V7 and resistance to enzalutamide and abiraterone in prostate cancer.

N Engl J Med 2014 Sep 3;371(11):1028-38. Epub 2014 Sep 3.

From the Departments of Oncology (E.S.A., H.W., B.L., J.T.I., R.N., C.J.P., S.R.D., M.A.C., M.A.E.), Pathology (H.L.F., T.L.L., Q.Z., A.M.D.M.), and Urology (C.L., M.N., J.C.R., Yan Chen, W.B.I., J.L.), Johns Hopkins University School of Medicine, Baltimore; and Greehey Children's Cancer Research Institute (T.A.M., Yidong Chen) and the Department of Epidemiology and Biostatistics (Yidong Chen), University of Texas Health Science Center at San Antonio, San Antonio.

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September 2014

Proposed morphologic classification of prostate cancer with neuroendocrine differentiation.

Am J Surg Pathol 2014 Jun;38(6):756-67

Departments of *Pathology †Urology ‡Oncology, The Johns Hopkins Medical Institutions, Baltimore, MD §Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA Departments of ∥Medicine ¶Pathology and Laboratory Medicine #Institute for Precision Medicine, Weill Medical College of Cornell University and New York-Presbyterian Hospital **Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY ††Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX.

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June 2014

Long interspersed element-1 protein expression is a hallmark of many human cancers.

Am J Pathol 2014 May 6;184(5):1280-6. Epub 2014 Mar 6.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland; High Throughput Biology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address:

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May 2014

Rb loss is characteristic of prostatic small cell neuroendocrine carcinoma.

Clin Cancer Res 2014 Feb 9;20(4):890-903. Epub 2013 Dec 9.

Authors' Affiliations: Pathology, Department of Pathology, Henry Ford Health System, Detroit, Michigan; Oncology, and Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland; and Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina.

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February 2014

mTOR signaling feedback modulates mammary epithelial differentiation and restrains invasion downstream of PTEN loss.

Cancer Res 2013 Aug 17;73(16):5218-31. Epub 2013 Jun 17.

Department of Pathology, Johns Hopkins University, Baltimore, MD, USA.

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August 2013

Prostatic stromal neoplasms: differential diagnosis of cystic and solid prostatic and periprostatic masses.

AJR Am J Roentgenol 2013 Jun;200(6):W571-80

The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Hospital, 601 N Caroline St, JHOC 3140C, Baltimore, MD 21287, USA.

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June 2013

Tight correlation of 5-hydroxymethylcytosine and Polycomb marks in health and disease.

Cell Cycle 2013 Jun 15;12(12):1835-41. Epub 2013 May 15.

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD, USA.

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June 2013