Talin Haritunians

Talin Haritunians

UNVERIFIED PROFILE

Are you Talin Haritunians?   Register this Author

Register author
Talin Haritunians

Talin Haritunians

Publications by authors named "Talin Haritunians"

Are you Talin Haritunians?   Register this Author

93Publications

4458Reads

44Profile Views

Ileal Gene Expression Data from Crohn's Disease Small Bowel Resections Indicate Distinct Clinical Subgroups.

J Crohns Colitis 2019 Aug;13(8):1055-1066

F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ecco-jcc/jjz021DOI Listing
August 2019

Late-Onset Crohn's Disease Is A Subgroup Distinct in Genetic and Behavioral Risk Factors With UC-Like Characteristics.

Inflamm Bowel Dis 2018 10;24(11):2413-2422

F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ibd/izy148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195175PMC
October 2018

Genetic Markers Predict Primary Nonresponse and Durable Response to Anti-Tumor Necrosis Factor Therapy in Ulcerative Colitis.

Inflamm Bowel Dis 2018 07;24(8):1840-1848

Inflammatory Bowel Disease Center, Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ibd/izy083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128143PMC
July 2018

Genetic associations with adverse events from anti-tumor necrosis factor therapy in inflammatory bowel disease patients.

World J Gastroenterol 2017 Oct;23(40):7265-7273

F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3748/wjg.v23.i40.7265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5677193PMC
October 2017

Colonic Phenotypes Are Associated with Poorer Response to Anti-TNF Therapies in Patients with IBD.

Inflamm Bowel Dis 2017 08;23(8):1382-1393

*F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California; †Department of Internal Medicine, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Korea; ‡Division of Hematology and Oncology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California; §Department of Gastroenterology and Inflammatory Bowel Disease Center, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea; and ‖Department of Pediatrics, Pediatric Inflammatory Bowel Disease Program, Cedars-Sinai Medical Center, Los Angeles, California.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MIB.0000000000001150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510223PMC
August 2017

Reply.

Gastroenterology 2017 06 5;152(8):2083-2084. Epub 2017 May 5.

Department of Pediatrics and Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.gastro.2017.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492261PMC
June 2017

The TNF family member TL1A induces IL-22 secretion in committed human T17 cells via IL-9 induction.

J Leukoc Biol 2017 03 12;101(3):727-737. Epub 2016 Oct 12.

F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1189/jlb.3A0316-129R
Publisher Site
http://dx.doi.org/10.1189/jlb.3A0316-129RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6608031PMC
March 2017

Genome-Wide Association Study Identifies African-Specific Susceptibility Loci in African Americans With Inflammatory Bowel Disease.

Gastroenterology 2017 01 28;152(1):206-217.e2. Epub 2016 Sep 28.

Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia; Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.gastro.2016.09.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5164948PMC
January 2017

A Frameshift in CSF2RB Predominant Among Ashkenazi Jews Increases Risk for Crohn's Disease and Reduces Monocyte Signaling via GM-CSF.

Gastroenterology 2016 10 1;151(4):710-723.e2. Epub 2016 Jul 1.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York; Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.gastro.2016.06.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037012PMC
October 2016

Linkage Analysis of High-density SNPs Confirms Keratoconus Locus at 5q Chromosomal Region.

Ophthalmic Genet 2016 20;37(1):109-10. Epub 2014 Feb 20.

a Cornea Genetic Eye Institute , Beverly Hills , California, 90211 , USA .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3109/13816810.2014.889172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139481PMC
September 2016

A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis.

Nat Commun 2016 08 9;7:12342. Epub 2016 Aug 9.

Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms12342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980482PMC
August 2016

Improved Performance of Dynamic Measures of Insulin Response Over Surrogate Indices to Identify Genetic Contributors of Type 2 Diabetes: The GUARDIAN Consortium.

Diabetes 2016 07 3;65(7):2072-80. Epub 2016 May 3.

Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, NC Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db15-1543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915581PMC
July 2016

TNFRSF1B Is Associated with ANCA in IBD.

Inflamm Bowel Dis 2016 06;22(6):1346-52

*Department of Medicine, F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California; †Mount Sinai Hospital, Toronto, Ontario, Canada; ‡The Susan and Leonard Feinstein IBD Clinical Center, East New York, New York; and §Institute for Translational Genomics and Population Science, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MIB.0000000000000771DOI Listing
June 2016

Perianal Crohn's Disease is Associated with Distal Colonic Disease, Stricturing Disease Behavior, IBD-Associated Serologies and Genetic Variation in the JAK-STAT Pathway.

Inflamm Bowel Dis 2016 Apr;22(4):862-9

*F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California; †Section of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine, Houston, Texas; ‡Division of Hematology and Oncology, Department of Medicine and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California; and §Pediatric Inflammatory Bowel Disease Center, Cedars-Sinai Medical Center, Los Angeles, California.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MIB.0000000000000705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220246PMC
April 2016

Identification of Ten Additional Susceptibility Loci for Ulcerative Colitis Through Immunochip Analysis in Koreans.

Inflamm Bowel Dis 2016 Jan;22(1):13-9

*Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; †Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul, Korea; ‡The F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute; Cedars-Sinai Medical Center, Los Angeles, California; §Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; ‖Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea; ¶Department of Life Science, Sogang University, Seoul, Korea; **Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea; ††Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Korea; and ‡‡Human Genetics, Genome Institute of Singapore, Singapore.

View Article

Download full-text PDF

Source
http://pdfs.journals.lww.com/ibdjournal/2016/01000/Identific
Web Search
http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
Publisher Site
http://dx.doi.org/10.1097/MIB.0000000000000584DOI Listing
January 2016

A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration.

Authors:
Paul S de Vries Daniel I Chasman Maria Sabater-Lleal Ming-Huei Chen Jennifer E Huffman Maristella Steri Weihong Tang Alexander Teumer Riccardo E Marioni Vera Grossmann Jouke J Hottenga Stella Trompet Martina Müller-Nurasyid Jing Hua Zhao Jennifer A Brody Marcus E Kleber Xiuqing Guo Jie Jin Wang Paul L Auer John R Attia Lisa R Yanek Tarunveer S Ahluwalia Jari Lahti Cristina Venturini Toshiko Tanaka Lawrence F Bielak Peter K Joshi Ares Rocanin-Arjo Ivana Kolcic Pau Navarro Lynda M Rose Christopher Oldmeadow Helene Riess Johanna Mazur Saonli Basu Anuj Goel Qiong Yang Mohsen Ghanbari Gonneke Willemsen Ann Rumley Edoardo Fiorillo Anton J M de Craen Anne Grotevendt Robert Scott Kent D Taylor Graciela E Delgado Jie Yao Annette Kifley Charles Kooperberg Rehan Qayyum Lorna M Lopez Tina L Berentzen Katri Räikkönen Massimo Mangino Stefania Bandinelli Patricia A Peyser Sarah Wild David-Alexandre Trégouët Alan F Wright Jonathan Marten Tatijana Zemunik Alanna C Morrison Bengt Sennblad Geoffrey Tofler Moniek P M de Maat Eco J C de Geus Gordon D Lowe Magdalena Zoledziewska Naveed Sattar Harald Binder Uwe Völker Melanie Waldenberger Kay-Tee Khaw Barbara Mcknight Jie Huang Nancy S Jenny Elizabeth G Holliday Lihong Qi Mark G Mcevoy Diane M Becker John M Starr Antti-Pekka Sarin Pirro G Hysi Dena G Hernandez Min A Jhun Harry Campbell Anders Hamsten Fernando Rivadeneira Wendy L Mcardle P Eline Slagboom Tanja Zeller Wolfgang Koenig Bruce M Psaty Talin Haritunians Jingmin Liu Aarno Palotie André G Uitterlinden David J Stott Albert Hofman Oscar H Franco Ozren Polasek Igor Rudan Pierre-Emmanuel Morange James F Wilson Sharon L R Kardia Luigi Ferrucci Tim D Spector Johan G Eriksson Torben Hansen Ian J Deary Lewis C Becker Rodney J Scott Paul Mitchell Winfried März Nick J Wareham Annette Peters Andreas Greinacher Philipp S Wild J Wouter Jukema Dorret I Boomsma Caroline Hayward Francesco Cucca Russell Tracy Hugh Watkins Alex P Reiner Aaron R Folsom Paul M Ridker Christopher J O'Donnell Nicholas L Smith David P Strachan Abbas Dehghan

Hum Mol Genet 2016 Jan 10;25(2):358-70. Epub 2015 Nov 10.

Department of Epidemiology,

View Article

Download full-text PDF

Source
http://hmg.oxfordjournals.org/content/early/2015/12/08/hmg.d
Web Search
http://www.hmg.oxfordjournals.org/lookup/doi/10.1093/hmg/ddv
Publisher Site
http://dx.doi.org/10.1093/hmg/ddv454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4715256PMC
January 2016

Association of NOD2 and IL23R with inflammatory bowel disease in Puerto Rico.

PLoS One 2014 26;9(9):e108204. Epub 2014 Sep 26.

Institute of Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor/UCLA Medical Center, Torrance, California, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0108204PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178120PMC
June 2015

Genetic Variants Associated With Quantitative Glucose Homeostasis Traits Translate to Type 2 Diabetes in Mexican Americans: The GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium.

Diabetes 2015 May 18;64(5):1853-66. Epub 2014 Dec 18.

Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, NC Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC

View Article

Download full-text PDF

Source
http://diabetes.diabetesjournals.org/content/early/2014/12/1
Web Search
http://diabetes.diabetesjournals.org/content/64/5/1853.full.
Web Search
http://diabetes.diabetesjournals.org/lookup/doi/10.2337/db14
Publisher Site
http://dx.doi.org/10.2337/db14-0732DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407862PMC
May 2015

Variation in PPARG is associated with longitudinal change in insulin resistance in Mexican Americans at risk for type 2 diabetes.

J Clin Endocrinol Metab 2015 Mar 13;100(3):1187-95. Epub 2015 Jan 13.

Department of Research & Evaluation (M.H.B., J.W., M.T., J.M.L., A.H.X.), Kaiser Permanente Southern California, Pasadena, California; Department of Preventive Medicine (N.W., R.M.W., T.A.B.), Keck School of Medicine of University of Southern California (USC), Los Angeles, California; Medical Genetics Institute (K.D.T., T.H.), Cedars-Sinai Medical Center, Los Angeles, California; Department of Medicine (E.T.), Keck School of Medicine of USC, Los Angeles, California; USC Diabetes and Obesity Research Institute (R.M.W., T.A.B.), Los Angeles, California; Department of Physiology & Biophysics (R.M.W., T.A.B.), Keck School of Medicine of USC, Los Angeles, California.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2014-3246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333029PMC
March 2015

Immunochip analysis identification of 6 additional susceptibility loci for Crohn's disease in Koreans.

Inflamm Bowel Dis 2015 Jan;21(1):1-7

1Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; 2Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul, Korea; 3Human Genetics Group, Genome Institute of Singapore, Singapore, Singapore; 4The F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California; 5Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; 6Division of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea; 7Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; 8Division of Gastroenterology and Hepatology, Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea; 9Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea; 10Department of Internal Medicine, Institute of Digestive Disease and Nutrition, Korea University College of Medicine, Ansan, Korea; 11Digestive Endoscopic Center, Seoul Song Do Colorectal Hospital, Seoul, Korea; 12Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea; 13Department of Life Science, Sogang University, Seoul, Korea; 14Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea; 15Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Korea; and 16Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, and 17Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California.

View Article

Download full-text PDF

Source
http://pdfs.journals.lww.com/ibdjournal/2015/01000/Immunochi
Web Search
http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
Publisher Site
http://dx.doi.org/10.1097/MIB.0000000000000268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4331109PMC
January 2015

Reprograming of gut microbiome energy metabolism by the FUT2 Crohn's disease risk polymorphism.

ISME J 2014 Nov 29;8(11):2193-206. Epub 2014 Apr 29.

1] Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA [2] Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ismej.2014.64DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992076PMC
November 2014

IFNG rs1861494 polymorphism is associated with IBD disease severity and functional changes in both IFNG methylation and protein secretion.

Inflamm Bowel Dis 2014 Oct;20(10):1794-801

F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MIB.0000000000000172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4327845PMC
October 2014

Use of animal models in elucidating disease pathogenesis in IBD.

Semin Immunopathol 2014 Sep 12;36(5):541-51. Epub 2014 Sep 12.

Cedars-Sinai Medical Center, Los Angeles, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00281-014-0444-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4205729PMC
September 2014

Genome-wide association of body fat distribution in African ancestry populations suggests new loci.

PLoS Genet 2013 15;9(8):e1003681. Epub 2013 Aug 15.

Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pgen.1003681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744443PMC
March 2014

Clinical, serologic, and genetic factors associated with pyoderma gangrenosum and erythema nodosum in inflammatory bowel disease patients.

Inflamm Bowel Dis 2014 Mar;20(3):525-33

*F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California; †Department of Pediatrics, Pediatric Inflammatory Bowel Disease Center, Cedars Sinai Medical Center, Los Angeles, California; ‡Meyerhoff Inflammatory Bowel Disease Center, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland; §Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland; ‖Department of Internal Medicine, Section of Digestive Diseases, Yale School of Medicine, New Haven, Connecticut; ¶Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; **Universite de Montreal and the Montreal Heart Institute, Research Center, Montreal, Canada; ††Mount Sinai Inflammatory Bowel Disease Center, University of Toronto, Toronto, Canada; ‡‡Institute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California; and §§Medical Genetics Research Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California.

View Article

Download full-text PDF

Source
http://pdfs.journals.lww.com/ibdjournal/2014/03000/Clinical,
Web Search
http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
Publisher Site
http://dx.doi.org/10.1097/01.MIB.0000442011.60285.68DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046633PMC
March 2014

Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.

Authors:
Maria Sabater-Lleal Jie Huang Daniel Chasman Silvia Naitza Abbas Dehghan Andrew D Johnson Alexander Teumer Alex P Reiner Lasse Folkersen Saonli Basu Alicja R Rudnicka Stella Trompet Anders Mälarstig Jens Baumert Joshua C Bis Xiuqing Guo Jouke J Hottenga So-Youn Shin Lorna M Lopez Jari Lahti Toshiko Tanaka Lisa R Yanek Tiphaine Oudot-Mellakh James F Wilson Pau Navarro Jennifer E Huffman Tatijana Zemunik Susan Redline Reena Mehra Drazen Pulanic Igor Rudan Alan F Wright Ivana Kolcic Ozren Polasek Sarah H Wild Harry Campbell J David Curb Robert Wallace Simin Liu Charles B Eaton Diane M Becker Lewis C Becker Stefania Bandinelli Katri Räikkönen Elisabeth Widen Aarno Palotie Myriam Fornage David Green Myron Gross Gail Davies Sarah E Harris David C Liewald John M Starr Frances M K Williams Peter J Grant Timothy D Spector Rona J Strawbridge Angela Silveira Bengt Sennblad Fernando Rivadeneira Andre G Uitterlinden Oscar H Franco Albert Hofman Jenny van Dongen Gonneke Willemsen Dorret I Boomsma Jie Yao Nancy Swords Jenny Talin Haritunians Barbara McKnight Thomas Lumley Kent D Taylor Jerome I Rotter Bruce M Psaty Annette Peters Christian Gieger Thomas Illig Anne Grotevendt Georg Homuth Henry Völzke Thomas Kocher Anuj Goel Maria Grazia Franzosi Udo Seedorf Robert Clarke Maristella Steri Kirill V Tarasov Serena Sanna David Schlessinger David J Stott Naveed Sattar Brendan M Buckley Ann Rumley Gordon D Lowe Wendy L McArdle Ming-Huei Chen Geoffrey H Tofler Jaejoon Song Eric Boerwinkle Aaron R Folsom Lynda M Rose Anders Franco-Cereceda Martina Teichert M Arfan Ikram Thomas H Mosley Steve Bevan Martin Dichgans Peter M Rothwell Cathie L M Sudlow Jemma C Hopewell John C Chambers Danish Saleheen Jaspal S Kooner John Danesh Christopher P Nelson Jeanette Erdmann Muredach P Reilly Sekar Kathiresan Heribert Schunkert Pierre-Emmanuel Morange Luigi Ferrucci Johan G Eriksson David Jacobs Ian J Deary Nicole Soranzo Jacqueline C M Witteman Eco J C de Geus Russell P Tracy Caroline Hayward Wolfgang Koenig Francesco Cucca J Wouter Jukema Per Eriksson Sudha Seshadri Hugh S Markus Hugh Watkins Nilesh J Samani Henri Wallaschofski Nicholas L Smith David Tregouet Paul M Ridker Weihong Tang David P Strachan Anders Hamsten Christopher J O'Donnell

Circulation 2013 Sep 22;128(12):1310-24. Epub 2013 Aug 22.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCULATIONAHA.113.002251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842025PMC
September 2013

A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.

Authors:
Keri L Monda Gary K Chen Kira C Taylor Cameron Palmer Todd L Edwards Leslie A Lange Maggie C Y Ng Adebowale A Adeyemo Matthew A Allison Lawrence F Bielak Guanjie Chen Mariaelisa Graff Marguerite R Irvin Suhn K Rhie Guo Li Yongmei Liu Youfang Liu Yingchang Lu Michael A Nalls Yan V Sun Mary K Wojczynski Lisa R Yanek Melinda C Aldrich Adeyinka Ademola Christopher I Amos Elisa V Bandera Cathryn H Bock Angela Britton Ulrich Broeckel Quiyin Cai Neil E Caporaso Chris S Carlson John Carpten Graham Casey Wei-Min Chen Fang Chen Yii-Der I Chen Charleston W K Chiang Gerhard A Coetzee Ellen Demerath Sandra L Deming-Halverson Ryan W Driver Patricia Dubbert Mary F Feitosa Ye Feng Barry I Freedman Elizabeth M Gillanders Omri Gottesman Xiuqing Guo Talin Haritunians Tamara Harris Curtis C Harris Anselm J M Hennis Dena G Hernandez Lorna H McNeill Timothy D Howard Barbara V Howard Virginia J Howard Karen C Johnson Sun J Kang Brendan J Keating Suzanne Kolb Lewis H Kuller Abdullah Kutlar Carl D Langefeld Guillaume Lettre Kurt Lohman Vaneet Lotay Helen Lyon Joann E Manson William Maixner Yan A Meng Kristine R Monroe Imran Morhason-Bello Adam B Murphy Josyf C Mychaleckyj Rajiv Nadukuru Katherine L Nathanson Uma Nayak Amidou N'diaye Barbara Nemesure Suh-Yuh Wu M Cristina Leske Christine Neslund-Dudas Marian Neuhouser Sarah Nyante Heather Ochs-Balcom Adesola Ogunniyi Temidayo O Ogundiran Oladosu Ojengbede Olufunmilayo I Olopade Julie R Palmer Edward A Ruiz-Narvaez Nicholette D Palmer Michael F Press Evandine Rampersaud Laura J Rasmussen-Torvik Jorge L Rodriguez-Gil Babatunde Salako Eric E Schadt Ann G Schwartz Daniel A Shriner David Siscovick Shad B Smith Sylvia Wassertheil-Smoller Elizabeth K Speliotes Margaret R Spitz Lara Sucheston Herman Taylor Bamidele O Tayo Margaret A Tucker David J Van Den Berg Digna R Velez Edwards Zhaoming Wang John K Wiencke Thomas W Winkler John S Witte Margaret Wrensch Xifeng Wu James J Yang Albert M Levin Taylor R Young Neil A Zakai Mary Cushman Krista A Zanetti Jing Hua Zhao Wei Zhao Yonglan Zheng Jie Zhou Regina G Ziegler Joseph M Zmuda Jyotika K Fernandes Gary S Gilkeson Diane L Kamen Kelly J Hunt Ida J Spruill Christine B Ambrosone Stefan Ambs Donna K Arnett Larry Atwood Diane M Becker Sonja I Berndt Leslie Bernstein William J Blot Ingrid B Borecki Erwin P Bottinger Donald W Bowden Gregory Burke Stephen J Chanock Richard S Cooper Jingzhong Ding David Duggan Michele K Evans Caroline Fox W Timothy Garvey Jonathan P Bradfield Hakon Hakonarson Struan F A Grant Ann Hsing Lisa Chu Jennifer J Hu Dezheng Huo Sue A Ingles Esther M John Joanne M Jordan Edmond K Kabagambe Sharon L R Kardia Rick A Kittles Phyllis J Goodman Eric A Klein Laurence N Kolonel Loic Le Marchand Simin Liu Barbara McKnight Robert C Millikan Thomas H Mosley Badri Padhukasahasram L Keoki Williams Sanjay R Patel Ulrike Peters Curtis A Pettaway Patricia A Peyser Bruce M Psaty Susan Redline Charles N Rotimi Benjamin A Rybicki Michèle M Sale Pamela J Schreiner Lisa B Signorello Andrew B Singleton Janet L Stanford Sara S Strom Michael J Thun Mara Vitolins Wei Zheng Jason H Moore Scott M Williams Shamika Ketkar Xiaofeng Zhu Alan B Zonderman Charles Kooperberg George J Papanicolaou Brian E Henderson Alex P Reiner Joel N Hirschhorn Ruth J F Loos Kari E North Christopher A Haiman

Nat Genet 2013 Jun 14;45(6):690-6. Epub 2013 Apr 14.

The Center for Observational Research, Amgen, Inc. Thousand Oaks, California, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.2608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694490PMC
June 2013

Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits.

Authors:
Joshua C Randall Thomas W Winkler Zoltán Kutalik Sonja I Berndt Anne U Jackson Keri L Monda Tuomas O Kilpeläinen Tõnu Esko Reedik Mägi Shengxu Li Tsegaselassie Workalemahu Mary F Feitosa Damien C Croteau-Chonka Felix R Day Tove Fall Teresa Ferreira Stefan Gustafsson Adam E Locke Iain Mathieson Andre Scherag Sailaja Vedantam Andrew R Wood Liming Liang Valgerdur Steinthorsdottir Gudmar Thorleifsson Emmanouil T Dermitzakis Antigone S Dimas Fredrik Karpe Josine L Min George Nicholson Deborah J Clegg Thomas Person Jon P Krohn Sabrina Bauer Christa Buechler Kristina Eisinger Amélie Bonnefond Philippe Froguel Jouke-Jan Hottenga Inga Prokopenko Lindsay L Waite Tamara B Harris Albert Vernon Smith Alan R Shuldiner Wendy L McArdle Mark J Caulfield Patricia B Munroe Henrik Grönberg Yii-Der Ida Chen Guo Li Jacques S Beckmann Toby Johnson Unnur Thorsteinsdottir Maris Teder-Laving Kay-Tee Khaw Nicholas J Wareham Jing Hua Zhao Najaf Amin Ben A Oostra Aldi T Kraja Michael A Province L Adrienne Cupples Nancy L Heard-Costa Jaakko Kaprio Samuli Ripatti Ida Surakka Francis S Collins Jouko Saramies Jaakko Tuomilehto Antti Jula Veikko Salomaa Jeanette Erdmann Christian Hengstenberg Christina Loley Heribert Schunkert Claudia Lamina H Erich Wichmann Eva Albrecht Christian Gieger Andrew A Hicks Asa Johansson Peter P Pramstaller Sekar Kathiresan Elizabeth K Speliotes Brenda Penninx Anna-Liisa Hartikainen Marjo-Riitta Jarvelin Ulf Gyllensten Dorret I Boomsma Harry Campbell James F Wilson Stephen J Chanock Martin Farrall Anuj Goel Carolina Medina-Gomez Fernando Rivadeneira Karol Estrada André G Uitterlinden Albert Hofman M Carola Zillikens Martin den Heijer Lambertus A Kiemeney Andrea Maschio Per Hall Jonathan Tyrer Alexander Teumer Henry Völzke Peter Kovacs Anke Tönjes Massimo Mangino Tim D Spector Caroline Hayward Igor Rudan Alistair S Hall Nilesh J Samani Antony Paul Attwood Jennifer G Sambrook Joseph Hung Lyle J Palmer Marja-Liisa Lokki Juha Sinisalo Gabrielle Boucher Heikki Huikuri Mattias Lorentzon Claes Ohlsson Niina Eklund Johan G Eriksson Cristina Barlassina Carlo Rivolta Ilja M Nolte Harold Snieder Melanie M Van der Klauw Jana V Van Vliet-Ostaptchouk Pablo V Gejman Jianxin Shi Kevin B Jacobs Zhaoming Wang Stephan J L Bakker Irene Mateo Leach Gerjan Navis Pim van der Harst Nicholas G Martin Sarah E Medland Grant W Montgomery Jian Yang Daniel I Chasman Paul M Ridker Lynda M Rose Terho Lehtimäki Olli Raitakari Devin Absher Carlos Iribarren Hanneke Basart Kees G Hovingh Elina Hyppönen Chris Power Denise Anderson John P Beilby Jennie Hui Jennifer Jolley Hendrik Sager Stefan R Bornstein Peter E H Schwarz Kati Kristiansson Markus Perola Jaana Lindström Amy J Swift Matti Uusitupa Mustafa Atalay Timo A Lakka Rainer Rauramaa Jennifer L Bolton Gerry Fowkes Ross M Fraser Jackie F Price Krista Fischer Kaarel Krjutå Kov Andres Metspalu Evelin Mihailov Claudia Langenberg Jian'an Luan Ken K Ong Peter S Chines Sirkka M Keinanen-Kiukaanniemi Timo E Saaristo Sarah Edkins Paul W Franks Göran Hallmans Dmitry Shungin Andrew David Morris Colin N A Palmer Raimund Erbel Susanne Moebus Markus M Nöthen Sonali Pechlivanis Kristian Hveem Narisu Narisu Anders Hamsten Steve E Humphries Rona J Strawbridge Elena Tremoli Harald Grallert Barbara Thorand Thomas Illig Wolfgang Koenig Martina Müller-Nurasyid Annette Peters Bernhard O Boehm Marcus E Kleber Winfried März Bernhard R Winkelmann Johanna Kuusisto Markku Laakso Dominique Arveiler Giancarlo Cesana Kari Kuulasmaa Jarmo Virtamo John W G Yarnell Diana Kuh Andrew Wong Lars Lind Ulf de Faire Bruna Gigante Patrik K E Magnusson Nancy L Pedersen George Dedoussis Maria Dimitriou Genovefa Kolovou Stavroula Kanoni Kathleen Stirrups Lori L Bonnycastle Inger Njølstad Tom Wilsgaard Andrea Ganna Emil Rehnberg Aroon Hingorani Mika Kivimaki Meena Kumari Themistocles L Assimes Inês Barroso Michael Boehnke Ingrid B Borecki Panos Deloukas Caroline S Fox Timothy Frayling Leif C Groop Talin Haritunians David Hunter Erik Ingelsson Robert Kaplan Karen L Mohlke Jeffrey R O'Connell David Schlessinger David P Strachan Kari Stefansson Cornelia M van Duijn Gonçalo R Abecasis Mark I McCarthy Joel N Hirschhorn Lu Qi Ruth J F Loos Cecilia M Lindgren Kari E North Iris M Heid

PLoS Genet 2013 Jun 6;9(6):e1003500. Epub 2013 Jun 6.

Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pgen.1003500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674993PMC
June 2013

A genome-wide association study of central corneal thickness in Latinos.

Invest Ophthalmol Vis Sci 2013 Apr 1;54(4):2435-43. Epub 2013 Apr 1.

Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1167/iovs.13-11692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621577PMC
April 2013

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.

Authors:
Luke Jostins Stephan Ripke Rinse K Weersma Richard H Duerr Dermot P McGovern Ken Y Hui James C Lee L Philip Schumm Yashoda Sharma Carl A Anderson Jonah Essers Mitja Mitrovic Kaida Ning Isabelle Cleynen Emilie Theatre Sarah L Spain Soumya Raychaudhuri Philippe Goyette Zhi Wei Clara Abraham Jean-Paul Achkar Tariq Ahmad Leila Amininejad Ashwin N Ananthakrishnan Vibeke Andersen Jane M Andrews Leonard Baidoo Tobias Balschun Peter A Bampton Alain Bitton Gabrielle Boucher Stephan Brand Carsten Büning Ariella Cohain Sven Cichon Mauro D'Amato Dirk De Jong Kathy L Devaney Marla Dubinsky Cathryn Edwards David Ellinghaus Lynnette R Ferguson Denis Franchimont Karin Fransen Richard Gearry Michel Georges Christian Gieger Jürgen Glas Talin Haritunians Ailsa Hart Chris Hawkey Matija Hedl Xinli Hu Tom H Karlsen Limas Kupcinskas Subra Kugathasan Anna Latiano Debby Laukens Ian C Lawrance Charlie W Lees Edouard Louis Gillian Mahy John Mansfield Angharad R Morgan Craig Mowat William Newman Orazio Palmieri Cyriel Y Ponsioen Uros Potocnik Natalie J Prescott Miguel Regueiro Jerome I Rotter Richard K Russell Jeremy D Sanderson Miquel Sans Jack Satsangi Stefan Schreiber Lisa A Simms Jurgita Sventoraityte Stephan R Targan Kent D Taylor Mark Tremelling Hein W Verspaget Martine De Vos Cisca Wijmenga David C Wilson Juliane Winkelmann Ramnik J Xavier Sebastian Zeissig Bin Zhang Clarence K Zhang Hongyu Zhao Mark S Silverberg Vito Annese Hakon Hakonarson Steven R Brant Graham Radford-Smith Christopher G Mathew John D Rioux Eric E Schadt Mark J Daly Andre Franke Miles Parkes Severine Vermeire Jeffrey C Barrett Judy H Cho

Nature 2012 Nov;491(7422):119-24

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature11582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491803PMC
November 2012

Genotype Imputation for Latinos Using the HapMap and 1000 Genomes Project Reference Panels.

Front Genet 2012 27;3:117. Epub 2012 Jun 27.

Department of Ophthalmology, Keck School of Medicine, University of Southern California Los Angeles, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fgene.2012.00117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384355PMC
October 2012

FTO genotype is associated with phenotypic variability of body mass index.

Authors:
Jian Yang Ruth J F Loos Joseph E Powell Sarah E Medland Elizabeth K Speliotes Daniel I Chasman Lynda M Rose Gudmar Thorleifsson Valgerdur Steinthorsdottir Reedik Mägi Lindsay Waite Albert Vernon Smith Laura M Yerges-Armstrong Keri L Monda David Hadley Anubha Mahajan Guo Li Karen Kapur Veronique Vitart Jennifer E Huffman Sophie R Wang Cameron Palmer Tõnu Esko Krista Fischer Jing Hua Zhao Ayşe Demirkan Aaron Isaacs Mary F Feitosa Jian'an Luan Nancy L Heard-Costa Charles White Anne U Jackson Michael Preuss Andreas Ziegler Joel Eriksson Zoltán Kutalik Francesca Frau Ilja M Nolte Jana V Van Vliet-Ostaptchouk Jouke-Jan Hottenga Kevin B Jacobs Niek Verweij Anuj Goel Carolina Medina-Gomez Karol Estrada Jennifer Lynn Bragg-Gresham Serena Sanna Carlo Sidore Jonathan Tyrer Alexander Teumer Inga Prokopenko Massimo Mangino Cecilia M Lindgren Themistocles L Assimes Alan R Shuldiner Jennie Hui John P Beilby Wendy L McArdle Per Hall Talin Haritunians Lina Zgaga Ivana Kolcic Ozren Polasek Tatijana Zemunik Ben A Oostra M Juhani Junttila Henrik Grönberg Stefan Schreiber Annette Peters Andrew A Hicks Jonathan Stephens Nicola S Foad Jaana Laitinen Anneli Pouta Marika Kaakinen Gonneke Willemsen Jacqueline M Vink Sarah H Wild Gerjan Navis Folkert W Asselbergs Georg Homuth Ulrich John Carlos Iribarren Tamara Harris Lenore Launer Vilmundur Gudnason Jeffrey R O'Connell Eric Boerwinkle Gemma Cadby Lyle J Palmer Alan L James Arthur W Musk Erik Ingelsson Bruce M Psaty Jacques S Beckmann Gerard Waeber Peter Vollenweider Caroline Hayward Alan F Wright Igor Rudan Leif C Groop Andres Metspalu Kay Tee Khaw Cornelia M van Duijn Ingrid B Borecki Michael A Province Nicholas J Wareham Jean-Claude Tardif Heikki V Huikuri L Adrienne Cupples Larry D Atwood Caroline S Fox Michael Boehnke Francis S Collins Karen L Mohlke Jeanette Erdmann Heribert Schunkert Christian Hengstenberg Klaus Stark Mattias Lorentzon Claes Ohlsson Daniele Cusi Jan A Staessen Melanie M Van der Klauw Peter P Pramstaller Sekar Kathiresan Jennifer D Jolley Samuli Ripatti Marjo-Riitta Jarvelin Eco J C de Geus Dorret I Boomsma Brenda Penninx James F Wilson Harry Campbell Stephen J Chanock Pim van der Harst Anders Hamsten Hugh Watkins Albert Hofman Jacqueline C Witteman M Carola Zillikens André G Uitterlinden Fernando Rivadeneira M Carola Zillikens Lambertus A Kiemeney Sita H Vermeulen Goncalo R Abecasis David Schlessinger Sabine Schipf Michael Stumvoll Anke Tönjes Tim D Spector Kari E North Guillaume Lettre Mark I McCarthy Sonja I Berndt Andrew C Heath Pamela A F Madden Dale R Nyholt Grant W Montgomery Nicholas G Martin Barbara McKnight David P Strachan William G Hill Harold Snieder Paul M Ridker Unnur Thorsteinsdottir Kari Stefansson Timothy M Frayling Joel N Hirschhorn Michael E Goddard Peter M Visscher

Nature 2012 Oct 16;490(7419):267-72. Epub 2012 Sep 16.

University of Queensland Diamantina Institute, The University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland 4102, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature11401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564953PMC
October 2012

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.

Authors:
Zari Dastani Marie-France Hivert Nicholas Timpson John R B Perry Xin Yuan Robert A Scott Peter Henneman Iris M Heid Jorge R Kizer Leo-Pekka Lyytikäinen Christian Fuchsberger Toshiko Tanaka Andrew P Morris Kerrin Small Aaron Isaacs Marian Beekman Stefan Coassin Kurt Lohman Lu Qi Stavroula Kanoni James S Pankow Hae-Won Uh Ying Wu Aurelian Bidulescu Laura J Rasmussen-Torvik Celia M T Greenwood Martin Ladouceur Jonna Grimsby Alisa K Manning Ching-Ti Liu Jaspal Kooner Vincent E Mooser Peter Vollenweider Karen A Kapur John Chambers Nicholas J Wareham Claudia Langenberg Rune Frants Ko Willems-Vandijk Ben A Oostra Sara M Willems Claudia Lamina Thomas W Winkler Bruce M Psaty Russell P Tracy Jennifer Brody Ida Chen Jorma Viikari Mika Kähönen Peter P Pramstaller David M Evans Beate St Pourcain Naveed Sattar Andrew R Wood Stefania Bandinelli Olga D Carlson Josephine M Egan Stefan Böhringer Diana van Heemst Lyudmyla Kedenko Kati Kristiansson Marja-Liisa Nuotio Britt-Marie Loo Tamara Harris Melissa Garcia Alka Kanaya Margot Haun Norman Klopp H-Erich Wichmann Panos Deloukas Efi Katsareli David J Couper Bruce B Duncan Margreet Kloppenburg Linda S Adair Judith B Borja James G Wilson Solomon Musani Xiuqing Guo Toby Johnson Robert Semple Tanya M Teslovich Matthew A Allison Susan Redline Sarah G Buxbaum Karen L Mohlke Ingrid Meulenbelt Christie M Ballantyne George V Dedoussis Frank B Hu Yongmei Liu Bernhard Paulweber Timothy D Spector P Eline Slagboom Luigi Ferrucci Antti Jula Markus Perola Olli Raitakari Jose C Florez Veikko Salomaa Johan G Eriksson Timothy M Frayling Andrew A Hicks Terho Lehtimäki George Davey Smith David S Siscovick Florian Kronenberg Cornelia van Duijn Ruth J F Loos Dawn M Waterworth James B Meigs Josee Dupuis J Brent Richards Benjamin F Voight Laura J Scott Valgerdur Steinthorsdottir Christian Dina Ryan P Welch Eleftheria Zeggini Cornelia Huth Yurii S Aulchenko Gudmar Thorleifsson Laura J McCulloch Teresa Ferreira Harald Grallert Najaf Amin Guanming Wu Cristen J Willer Soumya Raychaudhuri Steve A McCarroll Oliver M Hofmann Ayellet V Segrè Mandy van Hoek Pau Navarro Kristin Ardlie Beverley Balkau Rafn Benediktsson Amanda J Bennett Roza Blagieva Eric Boerwinkle Lori L Bonnycastle Kristina Bengtsson Boström Bert Bravenboer Suzannah Bumpstead Noël P Burtt Guillaume Charpentier Peter S Chines Marilyn Cornelis Gabe Crawford Alex S F Doney Katherine S Elliott Amanda L Elliott Michael R Erdos Caroline S Fox Christopher S Franklin Martha Ganser Christian Gieger Niels Grarup Todd Green Simon Griffin Christopher J Groves Candace Guiducci Samy Hadjadj Neelam Hassanali Christian Herder Bo Isomaa Anne U Jackson Paul R V Johnson Torben Jørgensen Wen H L Kao Augustine Kong Peter Kraft Johanna Kuusisto Torsten Lauritzen Man Li Aloysius Lieverse Cecilia M Lindgren Valeriya Lyssenko Michel Marre Thomas Meitinger Kristian Midthjell Mario A Morken Narisu Narisu Peter Nilsson Katharine R Owen Felicity Payne Ann-Kristin Petersen Carl Platou Christine Proença Inga Prokopenko Wolfgang Rathmann N William Rayner Neil R Robertson Ghislain Rocheleau Michael Roden Michael J Sampson Richa Saxena Beverley M Shields Peter Shrader Gunnar Sigurdsson Thomas Sparsø Klaus Strassburger Heather M Stringham Qi Sun Amy J Swift Barbara Thorand Jean Tichet Tiinamaija Tuomi Rob M van Dam Timon W van Haeften Thijs van Herpt Jana V van Vliet-Ostaptchouk G Bragi Walters Michael N Weedon Cisca Wijmenga Jacqueline Witteman Richard N Bergman Stephane Cauchi Francis S Collins Anna L Gloyn Ulf Gyllensten Torben Hansen Winston A Hide Graham A Hitman Albert Hofman David J Hunter Kristian Hveem Markku Laakso Andrew D Morris Colin N A Palmer Igor Rudan Eric Sijbrands Lincoln D Stein Jaakko Tuomilehto Andre Uitterlinden Mark Walker Richard M Watanabe Goncalo R Abecasis Bernhard O Boehm Harry Campbell Mark J Daly Andrew T Hattersley Oluf Pedersen Inês Barroso Leif Groop Rob Sladek Unnur Thorsteinsdottir James F Wilson Thomas Illig Philippe Froguel Cornelia M van Duijn Kari Stefansson David Altshuler Michael Boehnke Mark I McCarthy Nicole Soranzo Eleanor Wheeler Nicole L Glazer Nabila Bouatia-Naji Reedik Mägi Joshua Randall Paul Elliott Denis Rybin Abbas Dehghan Jouke Jan Hottenga Kijoung Song Anuj Goel Taina Lajunen Alex Doney Christine Cavalcanti-Proença Meena Kumari Nicholas J Timpson Carina Zabena Erik Ingelsson Ping An Jeffrey O'Connell Jian'an Luan Amanda Elliott Steven A McCarroll Rosa Maria Roccasecca François Pattou Praveen Sethupathy Yavuz Ariyurek Philip Barter John P Beilby Yoav Ben-Shlomo Sven Bergmann Murielle Bochud Amélie Bonnefond Knut Borch-Johnsen Yvonne Böttcher Eric Brunner Suzannah J Bumpstead Yii-Der Ida Chen Peter Chines Robert Clarke Lachlan J M Coin Matthew N Cooper Laura Crisponi Ian N M Day Eco J C de Geus Jerome Delplanque Annette C Fedson Antje Fischer-Rosinsky Nita G Forouhi Maria Grazia Franzosi Pilar Galan Mark O Goodarzi Jürgen Graessler Scott Grundy Rhian Gwilliam Göran Hallmans Naomi Hammond Xijing Han Anna-Liisa Hartikainen Caroline Hayward Simon C Heath Serge Hercberg David R Hillman Aroon D Hingorani Jennie Hui Joe Hung Marika Kaakinen Jaakko Kaprio Y Antero Kesaniemi Mika Kivimaki Beatrice Knight Seppo Koskinen Peter Kovacs Kirsten Ohm Kyvik G Mark Lathrop Debbie A Lawlor Olivier Le Bacquer Cécile Lecoeur Yun Li Robert Mahley Massimo Mangino María Teresa Martínez-Larrad Jarred B McAteer Ruth McPherson Christa Meisinger David Melzer David Meyre Braxton D Mitchell Sutapa Mukherjee Silvia Naitza Matthew J Neville Marco Orrù Ruth Pakyz Giuseppe Paolisso Cristian Pattaro Daniel Pearson John F Peden Nancy L Pedersen Andreas F H Pfeiffer Irene Pichler Ozren Polasek Danielle Posthuma Simon C Potter Anneli Pouta Michael A Province Nigel W Rayner Kenneth Rice Samuli Ripatti Fernando Rivadeneira Olov Rolandsson Annelli Sandbaek Manjinder Sandhu Serena Sanna Avan Aihie Sayer Paul Scheet Udo Seedorf Stephen J Sharp Beverley Shields Gunnar Sigurðsson Eric J G Sijbrands Angela Silveira Laila Simpson Andrew Singleton Nicholas L Smith Ulla Sovio Amy Swift Holly Syddall Ann-Christine Syvänen Anke Tönjes André G Uitterlinden Ko Willems van Dijk Dhiraj Varma Sophie Visvikis-Siest Veronique Vitart Nicole Vogelzangs Gérard Waeber Peter J Wagner Andrew Walley Kim L Ward Hugh Watkins Sarah H Wild Gonneke Willemsen Jaqueline C M Witteman John W G Yarnell Diana Zelenika Björn Zethelius Guangju Zhai Jing Hua Zhao M Carola Zillikens Ingrid B Borecki Pierre Meneton Patrik K E Magnusson David M Nathan Gordon H Williams Kaisa Silander Stefan R Bornstein Peter Schwarz Joachim Spranger Fredrik Karpe Alan R Shuldiner Cyrus Cooper Manuel Serrano-Ríos Lars Lind Lyle J Palmer Frank B Hu Paul W Franks Shah Ebrahim Michael Marmot W H Linda Kao Peter Paul Pramstaller Alan F Wright Michael Stumvoll Anders Hamsten Thomas A Buchanan Timo T Valle Jerome I Rotter Brenda W J H Penninx Dorret I Boomsma Antonio Cao Angelo Scuteri David Schlessinger Manuela Uda Aimo Ruokonen Marjo-Riitta Jarvelin Leena Peltonen Vincent Mooser Robert Sladek Kiran Musunuru Albert V Smith Andrew C Edmondson Ioannis M Stylianou Masahiro Koseki James P Pirruccello Daniel I Chasman Christopher T Johansen Sigrid W Fouchier Gina M Peloso Maja Barbalic Sally L Ricketts Joshua C Bis Mary F Feitosa Marju Orho-Melander Olle Melander Xiaohui Li Mingyao Li Yoon Shin Cho Min Jin Go Young Jin Kim Jong-Young Lee Taesung Park Kyunga Kim Xueling Sim Rick Twee-Hee Ong Damien C Croteau-Chonka Leslie A Lange Joshua D Smith Andreas Ziegler Weihua Zhang Robert Y L Zee John B Whitfield John R Thompson Ida Surakka Tim D Spector Johannes H Smit Juha Sinisalo James Scott Juha Saharinen Chiara Sabatti Lynda M Rose Robert Roberts Mark Rieder Alex N Parker Guillaume Pare Christopher J O'Donnell Markku S Nieminen Deborah A Nickerson Grant W Montgomery Wendy McArdle David Masson Nicholas G Martin Fabio Marroni Gavin Lucas Robert Luben Marja-Liisa Lokki Guillaume Lettre Lenore J Launer Edward G Lakatta Reijo Laaksonen Kirsten O Kyvik Inke R König Kay-Tee Khaw Lee M Kaplan Åsa Johansson A Cecile J W Janssens Wilmar Igl G Kees Hovingh Christian Hengstenberg Aki S Havulinna Nicholas D Hastie Tamara B Harris Talin Haritunians Alistair S Hall Leif C Groop Elena Gonzalez Nelson B Freimer Jeanette Erdmann Kenechi G Ejebe Angela Döring Anna F Dominiczak Serkalem Demissie Panagiotis Deloukas Ulf de Faire Gabriel Crawford Yii-der I Chen Mark J Caulfield S Matthijs Boekholdt Themistocles L Assimes Thomas Quertermous Mark Seielstad Tien Y Wong E-Shyong Tai Alan B Feranil Christopher W Kuzawa Herman A Taylor Stacey B Gabriel Hilma Holm Vilmundur Gudnason Ronald M Krauss Jose M Ordovas Patricia B Munroe Jaspal S Kooner Alan R Tall Robert A Hegele John J P Kastelein Eric E Schadt David P Strachan Muredach P Reilly Nilesh J Samani Heribert Schunkert L Adrienne Cupples Manjinder S Sandhu Paul M Ridker Daniel J Rader Sekar Kathiresan

PLoS Genet 2012 29;8(3):e1002607. Epub 2012 Mar 29.

Department of Epidemiology, Biostatistics, and Occupational Health, Jewish General Hospital, Lady Davis Institute, McGill University, Montreal, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pgen.1002607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315470PMC
September 2012

Variation in the lysyl oxidase (LOX) gene is associated with keratoconus in family-based and case-control studies.

Invest Ophthalmol Vis Sci 2012 Jun 28;53(7):4152-7. Epub 2012 Jun 28.

Regenerative Medicine Institute, Ophthalmology Research, Department of Surgery, Division of Surgical Research, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1167/iovs.11-9268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760233PMC
June 2012

Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile.

Authors:
Tuomas O Kilpeläinen M Carola Zillikens Alena Stančákova Francis M Finucane Janina S Ried Claudia Langenberg Weihua Zhang Jacques S Beckmann Jian'an Luan Liesbeth Vandenput Unnur Styrkarsdottir Yanhua Zhou Albert Vernon Smith Jing-Hua Zhao Najaf Amin Sailaja Vedantam So-Youn Shin Talin Haritunians Mao Fu Mary F Feitosa Meena Kumari Bjarni V Halldorsson Emmi Tikkanen Massimo Mangino Caroline Hayward Ci Song Alice M Arnold Yurii S Aulchenko Ben A Oostra Harry Campbell L Adrienne Cupples Kathryn E Davis Angela Döring Gudny Eiriksdottir Karol Estrada José Manuel Fernández-Real Melissa Garcia Christian Gieger Nicole L Glazer Candace Guiducci Albert Hofman Steve E Humphries Bo Isomaa Leonie C Jacobs Antti Jula David Karasik Magnus K Karlsson Kay-Tee Khaw Lauren J Kim Mika Kivimäki Norman Klopp Brigitte Kühnel Johanna Kuusisto Yongmei Liu Osten Ljunggren Mattias Lorentzon Robert N Luben Barbara McKnight Dan Mellström Braxton D Mitchell Vincent Mooser José Maria Moreno Satu Männistö Jeffery R O'Connell Laura Pascoe Leena Peltonen Belén Peral Markus Perola Bruce M Psaty Veikko Salomaa David B Savage Robert K Semple Tatjana Skaric-Juric Gunnar Sigurdsson Kijoung S Song Timothy D Spector Ann-Christine Syvänen Philippa J Talmud Gudmar Thorleifsson Unnur Thorsteinsdottir André G Uitterlinden Cornelia M van Duijn Antonio Vidal-Puig Sarah H Wild Alan F Wright Deborah J Clegg Eric Schadt James F Wilson Igor Rudan Samuli Ripatti Ingrid B Borecki Alan R Shuldiner Erik Ingelsson John-Olov Jansson Robert C Kaplan Vilmundur Gudnason Tamara B Harris Leif Groop Douglas P Kiel Fernando Rivadeneira Mark Walker Inês Barroso Peter Vollenweider Gérard Waeber John C Chambers Jaspal S Kooner Nicole Soranzo Joel N Hirschhorn Kari Stefansson H-Erich Wichmann Claes Ohlsson Stephen O'Rahilly Nicholas J Wareham Elizabeth K Speliotes Caroline S Fox Markku Laakso Ruth J F Loos

Nat Genet 2011 Jun 26;43(8):753-60. Epub 2011 Jun 26.

Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.866DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262230PMC
June 2011

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.

Authors:
Carl A Anderson Gabrielle Boucher Charlie W Lees Andre Franke Mauro D'Amato Kent D Taylor James C Lee Philippe Goyette Marcin Imielinski Anna Latiano Caroline Lagacé Regan Scott Leila Amininejad Suzannah Bumpstead Leonard Baidoo Robert N Baldassano Murray Barclay Theodore M Bayless Stephan Brand Carsten Büning Jean-Frédéric Colombel Lee A Denson Martine De Vos Marla Dubinsky Cathryn Edwards David Ellinghaus Rudolf S N Fehrmann James A B Floyd Timothy Florin Denis Franchimont Lude Franke Michel Georges Jürgen Glas Nicole L Glazer Stephen L Guthery Talin Haritunians Nicholas K Hayward Jean-Pierre Hugot Gilles Jobin Debby Laukens Ian Lawrance Marc Lémann Arie Levine Cecile Libioulle Edouard Louis Dermot P McGovern Monica Milla Grant W Montgomery Katherine I Morley Craig Mowat Aylwin Ng William Newman Roel A Ophoff Laura Papi Orazio Palmieri Laurent Peyrin-Biroulet Julián Panés Anne Phillips Natalie J Prescott Deborah D Proctor Rebecca Roberts Richard Russell Paul Rutgeerts Jeremy Sanderson Miquel Sans Philip Schumm Frank Seibold Yashoda Sharma Lisa A Simms Mark Seielstad A Hillary Steinhart Stephan R Targan Leonard H van den Berg Morten Vatn Hein Verspaget Thomas Walters Cisca Wijmenga David C Wilson Harm-Jan Westra Ramnik J Xavier Zhen Z Zhao Cyriel Y Ponsioen Vibeke Andersen Leif Torkvist Maria Gazouli Nicholas P Anagnou Tom H Karlsen Limas Kupcinskas Jurgita Sventoraityte John C Mansfield Subra Kugathasan Mark S Silverberg Jonas Halfvarson Jerome I Rotter Christopher G Mathew Anne M Griffiths Richard Gearry Tariq Ahmad Steven R Brant Mathias Chamaillard Jack Satsangi Judy H Cho Stefan Schreiber Mark J Daly Jeffrey C Barrett Miles Parkes Vito Annese Hakon Hakonarson Graham Radford-Smith Richard H Duerr Séverine Vermeire Rinse K Weersma John D Rioux

Nat Genet 2011 Mar 6;43(3):246-52. Epub 2011 Feb 6.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084597PMC
March 2011

CUBN is a gene locus for albuminuria.

Authors:
Carsten A Böger Ming-Huei Chen Adrienne Tin Matthias Olden Anna Köttgen Ian H de Boer Christian Fuchsberger Conall M O'Seaghdha Cristian Pattaro Alexander Teumer Ching-Ti Liu Nicole L Glazer Man Li Jeffrey R O'Connell Toshiko Tanaka Carmen A Peralta Zoltán Kutalik Jian'an Luan Jing Hua Zhao Shih-Jen Hwang Ermeg Akylbekova Holly Kramer Pim van der Harst Albert V Smith Kurt Lohman Mariza de Andrade Caroline Hayward Barbara Kollerits Anke Tönjes Thor Aspelund Erik Ingelsson Gudny Eiriksdottir Lenore J Launer Tamara B Harris Alan R Shuldiner Braxton D Mitchell Dan E Arking Nora Franceschini Eric Boerwinkle Josephine Egan Dena Hernandez Muredach Reilly Raymond R Townsend Thomas Lumley David S Siscovick Bruce M Psaty Bryan Kestenbaum Talin Haritunians Sven Bergmann Peter Vollenweider Gerard Waeber Vincent Mooser Dawn Waterworth Andrew D Johnson Jose C Florez James B Meigs Xiaoning Lu Stephen T Turner Elizabeth J Atkinson Tennille S Leak Knut Aasarød Frank Skorpen Ann-Christine Syvänen Thomas Illig Jens Baumert Wolfgang Koenig Bernhard K Krämer Olivier Devuyst Josyf C Mychaleckyj Cosetta Minelli Stephan J L Bakker Lyudmyla Kedenko Bernhard Paulweber Stefan Coassin Karlhans Endlich Heyo K Kroemer Reiner Biffar Sylvia Stracke Henry Völzke Michael Stumvoll Reedik Mägi Harry Campbell Veronique Vitart Nicholas D Hastie Vilmundur Gudnason Sharon L R Kardia Yongmei Liu Ozren Polasek Gary Curhan Florian Kronenberg Inga Prokopenko Igor Rudan Johan Arnlöv Stein Hallan Gerjan Navis Afshin Parsa Luigi Ferrucci Josef Coresh Michael G Shlipak Shelley B Bull Nicholas J Paterson H-Erich Wichmann Nicholas J Wareham Ruth J F Loos Jerome I Rotter Peter P Pramstaller L Adrienne Cupples Jacques S Beckmann Qiong Yang Iris M Heid Rainer Rettig Albert W Dreisbach Murielle Bochud Caroline S Fox W H L Kao

J Am Soc Nephrol 2011 Mar;22(3):555-70

Department of Internal Medicine II, University Medical Center Regensburg, Regensburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1681/ASN.2010060598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060449PMC
March 2011

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.

Nat Genet 2010 Dec;42(12):1118-25

Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel, Kiel, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299551PMC
December 2010

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.

Authors:
Iris M Heid Anne U Jackson Joshua C Randall Thomas W Winkler Lu Qi Valgerdur Steinthorsdottir Gudmar Thorleifsson M Carola Zillikens Elizabeth K Speliotes Reedik Mägi Tsegaselassie Workalemahu Charles C White Nabila Bouatia-Naji Tamara B Harris Sonja I Berndt Erik Ingelsson Cristen J Willer Michael N Weedon Jian'an Luan Sailaja Vedantam Tõnu Esko Tuomas O Kilpeläinen Zoltán Kutalik Shengxu Li Keri L Monda Anna L Dixon Christopher C Holmes Lee M Kaplan Liming Liang Josine L Min Miriam F Moffatt Cliona Molony George Nicholson Eric E Schadt Krina T Zondervan Mary F Feitosa Teresa Ferreira Hana Lango Allen Robert J Weyant Eleanor Wheeler Andrew R Wood Karol Estrada Michael E Goddard Guillaume Lettre Massimo Mangino Dale R Nyholt Shaun Purcell Albert Vernon Smith Peter M Visscher Jian Yang Steven A McCarroll James Nemesh Benjamin F Voight Devin Absher Najaf Amin Thor Aspelund Lachlan Coin Nicole L Glazer Caroline Hayward Nancy L Heard-Costa Jouke-Jan Hottenga Asa Johansson Toby Johnson Marika Kaakinen Karen Kapur Shamika Ketkar Joshua W Knowles Peter Kraft Aldi T Kraja Claudia Lamina Michael F Leitzmann Barbara McKnight Andrew P Morris Ken K Ong John R B Perry Marjolein J Peters Ozren Polasek Inga Prokopenko Nigel W Rayner Samuli Ripatti Fernando Rivadeneira Neil R Robertson Serena Sanna Ulla Sovio Ida Surakka Alexander Teumer Sophie van Wingerden Veronique Vitart Jing Hua Zhao Christine Cavalcanti-Proença Peter S Chines Eva Fisher Jennifer R Kulzer Cecile Lecoeur Narisu Narisu Camilla Sandholt Laura J Scott Kaisa Silander Klaus Stark Mari-Liis Tammesoo Tanya M Teslovich Nicholas John Timpson Richard M Watanabe Ryan Welch Daniel I Chasman Matthew N Cooper John-Olov Jansson Johannes Kettunen Robert W Lawrence Niina Pellikka Markus Perola Liesbeth Vandenput Helene Alavere Peter Almgren Larry D Atwood Amanda J Bennett Reiner Biffar Lori L Bonnycastle Stefan R Bornstein Thomas A Buchanan Harry Campbell Ian N M Day Mariano Dei Marcus Dörr Paul Elliott Michael R Erdos Johan G Eriksson Nelson B Freimer Mao Fu Stefan Gaget Eco J C Geus Anette P Gjesing Harald Grallert Jürgen Grässler Christopher J Groves Candace Guiducci Anna-Liisa Hartikainen Neelam Hassanali Aki S Havulinna Karl-Heinz Herzig Andrew A Hicks Jennie Hui Wilmar Igl Pekka Jousilahti Antti Jula Eero Kajantie Leena Kinnunen Ivana Kolcic Seppo Koskinen Peter Kovacs Heyo K Kroemer Vjekoslav Krzelj Johanna Kuusisto Kirsti Kvaloy Jaana Laitinen Olivier Lantieri G Mark Lathrop Marja-Liisa Lokki Robert N Luben Barbara Ludwig Wendy L McArdle Anne McCarthy Mario A Morken Mari Nelis Matt J Neville Guillaume Paré Alex N Parker John F Peden Irene Pichler Kirsi H Pietiläinen Carl G P Platou Anneli Pouta Martin Ridderstråle Nilesh J Samani Jouko Saramies Juha Sinisalo Jan H Smit Rona J Strawbridge Heather M Stringham Amy J Swift Maris Teder-Laving Brian Thomson Gianluca Usala Joyce B J van Meurs Gert-Jan van Ommen Vincent Vatin Claudia B Volpato Henri Wallaschofski G Bragi Walters Elisabeth Widen Sarah H Wild Gonneke Willemsen Daniel R Witte Lina Zgaga Paavo Zitting John P Beilby Alan L James Mika Kähönen Terho Lehtimäki Markku S Nieminen Claes Ohlsson Lyle J Palmer Olli Raitakari Paul M Ridker Michael Stumvoll Anke Tönjes Jorma Viikari Beverley Balkau Yoav Ben-Shlomo Richard N Bergman Heiner Boeing George Davey Smith Shah Ebrahim Philippe Froguel Torben Hansen Christian Hengstenberg Kristian Hveem Bo Isomaa Torben Jørgensen Fredrik Karpe Kay-Tee Khaw Markku Laakso Debbie A Lawlor Michel Marre Thomas Meitinger Andres Metspalu Kristian Midthjell Oluf Pedersen Veikko Salomaa Peter E H Schwarz Tiinamaija Tuomi Jaakko Tuomilehto Timo T Valle Nicholas J Wareham Alice M Arnold Jacques S Beckmann Sven Bergmann Eric Boerwinkle Dorret I Boomsma Mark J Caulfield Francis S Collins Gudny Eiriksdottir Vilmundur Gudnason Ulf Gyllensten Anders Hamsten Andrew T Hattersley Albert Hofman Frank B Hu Thomas Illig Carlos Iribarren Marjo-Riitta Jarvelin W H Linda Kao Jaakko Kaprio Lenore J Launer Patricia B Munroe Ben Oostra Brenda W Penninx Peter P Pramstaller Bruce M Psaty Thomas Quertermous Aila Rissanen Igor Rudan Alan R Shuldiner Nicole Soranzo Timothy D Spector Ann-Christine Syvanen Manuela Uda André Uitterlinden Henry Völzke Peter Vollenweider James F Wilson Jacqueline C Witteman Alan F Wright Gonçalo R Abecasis Michael Boehnke Ingrid B Borecki Panos Deloukas Timothy M Frayling Leif C Groop Talin Haritunians David J Hunter Robert C Kaplan Kari E North Jeffrey R O'Connell Leena Peltonen David Schlessinger David P Strachan Joel N Hirschhorn Themistocles L Assimes H-Erich Wichmann Unnur Thorsteinsdottir Cornelia M van Duijn Kari Stefansson L Adrienne Cupples Ruth J F Loos Inês Barroso Mark I McCarthy Caroline S Fox Karen L Mohlke Cecilia M Lindgren

Nat Genet 2010 Nov 10;42(11):949-60. Epub 2010 Oct 10.

Regensburg University Medical Center, Department of Epidemiology and Preventive Medicine, Regensburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000924PMC
November 2010

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.

Authors:
Elizabeth K Speliotes Cristen J Willer Sonja I Berndt Keri L Monda Gudmar Thorleifsson Anne U Jackson Hana Lango Allen Cecilia M Lindgren Jian'an Luan Reedik Mägi Joshua C Randall Sailaja Vedantam Thomas W Winkler Lu Qi Tsegaselassie Workalemahu Iris M Heid Valgerdur Steinthorsdottir Heather M Stringham Michael N Weedon Eleanor Wheeler Andrew R Wood Teresa Ferreira Robert J Weyant Ayellet V Segrè Karol Estrada Liming Liang James Nemesh Ju-Hyun Park Stefan Gustafsson Tuomas O Kilpeläinen Jian Yang Nabila Bouatia-Naji Tõnu Esko Mary F Feitosa Zoltán Kutalik Massimo Mangino Soumya Raychaudhuri Andre Scherag Albert Vernon Smith Ryan Welch Jing Hua Zhao Katja K Aben Devin M Absher Najaf Amin Anna L Dixon Eva Fisher Nicole L Glazer Michael E Goddard Nancy L Heard-Costa Volker Hoesel Jouke-Jan Hottenga Asa Johansson Toby Johnson Shamika Ketkar Claudia Lamina Shengxu Li Miriam F Moffatt Richard H Myers Narisu Narisu John R B Perry Marjolein J Peters Michael Preuss Samuli Ripatti Fernando Rivadeneira Camilla Sandholt Laura J Scott Nicholas J Timpson Jonathan P Tyrer Sophie van Wingerden Richard M Watanabe Charles C White Fredrik Wiklund Christina Barlassina Daniel I Chasman Matthew N Cooper John-Olov Jansson Robert W Lawrence Niina Pellikka Inga Prokopenko Jianxin Shi Elisabeth Thiering Helene Alavere Maria T S Alibrandi Peter Almgren Alice M Arnold Thor Aspelund Larry D Atwood Beverley Balkau Anthony J Balmforth Amanda J Bennett Yoav Ben-Shlomo Richard N Bergman Sven Bergmann Heike Biebermann Alexandra I F Blakemore Tanja Boes Lori L Bonnycastle Stefan R Bornstein Morris J Brown Thomas A Buchanan Fabio Busonero Harry Campbell Francesco P Cappuccio Christine Cavalcanti-Proença Yii-Der Ida Chen Chih-Mei Chen Peter S Chines Robert Clarke Lachlan Coin John Connell Ian N M Day Martin den Heijer Jubao Duan Shah Ebrahim Paul Elliott Roberto Elosua Gudny Eiriksdottir Michael R Erdos Johan G Eriksson Maurizio F Facheris Stephan B Felix Pamela Fischer-Posovszky Aaron R Folsom Nele Friedrich Nelson B Freimer Mao Fu Stefan Gaget Pablo V Gejman Eco J C Geus Christian Gieger Anette P Gjesing Anuj Goel Philippe Goyette Harald Grallert Jürgen Grässler Danielle M Greenawalt Christopher J Groves Vilmundur Gudnason Candace Guiducci Anna-Liisa Hartikainen Neelam Hassanali Alistair S Hall Aki S Havulinna Caroline Hayward Andrew C Heath Christian Hengstenberg Andrew A Hicks Anke Hinney Albert Hofman Georg Homuth Jennie Hui Wilmar Igl Carlos Iribarren Bo Isomaa Kevin B Jacobs Ivonne Jarick Elizabeth Jewell Ulrich John Torben Jørgensen Pekka Jousilahti Antti Jula Marika Kaakinen Eero Kajantie Lee M Kaplan Sekar Kathiresan Johannes Kettunen Leena Kinnunen Joshua W Knowles Ivana Kolcic Inke R König Seppo Koskinen Peter Kovacs Johanna Kuusisto Peter Kraft Kirsti Kvaløy Jaana Laitinen Olivier Lantieri Chiara Lanzani Lenore J Launer Cecile Lecoeur Terho Lehtimäki Guillaume Lettre Jianjun Liu Marja-Liisa Lokki Mattias Lorentzon Robert N Luben Barbara Ludwig Paolo Manunta Diana Marek Michel Marre Nicholas G Martin Wendy L McArdle Anne McCarthy Barbara McKnight Thomas Meitinger Olle Melander David Meyre Kristian Midthjell Grant W Montgomery Mario A Morken Andrew P Morris Rosanda Mulic Julius S Ngwa Mari Nelis Matt J Neville Dale R Nyholt Christopher J O'Donnell Stephen O'Rahilly Ken K Ong Ben Oostra Guillaume Paré Alex N Parker Markus Perola Irene Pichler Kirsi H Pietiläinen Carl G P Platou Ozren Polasek Anneli Pouta Suzanne Rafelt Olli Raitakari Nigel W Rayner Martin Ridderstråle Winfried Rief Aimo Ruokonen Neil R Robertson Peter Rzehak Veikko Salomaa Alan R Sanders Manjinder S Sandhu Serena Sanna Jouko Saramies Markku J Savolainen Susann Scherag Sabine Schipf Stefan Schreiber Heribert Schunkert Kaisa Silander Juha Sinisalo David S Siscovick Jan H Smit Nicole Soranzo Ulla Sovio Jonathan Stephens Ida Surakka Amy J Swift Mari-Liis Tammesoo Jean-Claude Tardif Maris Teder-Laving Tanya M Teslovich John R Thompson Brian Thomson Anke Tönjes Tiinamaija Tuomi Joyce B J van Meurs Gert-Jan van Ommen Vincent Vatin Jorma Viikari Sophie Visvikis-Siest Veronique Vitart Carla I G Vogel Benjamin F Voight Lindsay L Waite Henri Wallaschofski G Bragi Walters Elisabeth Widen Susanna Wiegand Sarah H Wild Gonneke Willemsen Daniel R Witte Jacqueline C Witteman Jianfeng Xu Qunyuan Zhang Lina Zgaga Andreas Ziegler Paavo Zitting John P Beilby I Sadaf Farooqi Johannes Hebebrand Heikki V Huikuri Alan L James Mika Kähönen Douglas F Levinson Fabio Macciardi Markku S Nieminen Claes Ohlsson Lyle J Palmer Paul M Ridker Michael Stumvoll Jacques S Beckmann Heiner Boeing Eric Boerwinkle Dorret I Boomsma Mark J Caulfield Stephen J Chanock Francis S Collins L Adrienne Cupples George Davey Smith Jeanette Erdmann Philippe Froguel Henrik Grönberg Ulf Gyllensten Per Hall Torben Hansen Tamara B Harris Andrew T Hattersley Richard B Hayes Joachim Heinrich Frank B Hu Kristian Hveem Thomas Illig Marjo-Riitta Jarvelin Jaakko Kaprio Fredrik Karpe Kay-Tee Khaw Lambertus A Kiemeney Heiko Krude Markku Laakso Debbie A Lawlor Andres Metspalu Patricia B Munroe Willem H Ouwehand Oluf Pedersen Brenda W Penninx Annette Peters Peter P Pramstaller Thomas Quertermous Thomas Reinehr Aila Rissanen Igor Rudan Nilesh J Samani Peter E H Schwarz Alan R Shuldiner Timothy D Spector Jaakko Tuomilehto Manuela Uda André Uitterlinden Timo T Valle Martin Wabitsch Gérard Waeber Nicholas J Wareham Hugh Watkins James F Wilson Alan F Wright M Carola Zillikens Nilanjan Chatterjee Steven A McCarroll Shaun Purcell Eric E Schadt Peter M Visscher Themistocles L Assimes Ingrid B Borecki Panos Deloukas Caroline S Fox Leif C Groop Talin Haritunians David J Hunter Robert C Kaplan Karen L Mohlke Jeffrey R O'Connell Leena Peltonen David Schlessinger David P Strachan Cornelia M van Duijn H-Erich Wichmann Timothy M Frayling Unnur Thorsteinsdottir Gonçalo R Abecasis Inês Barroso Michael Boehnke Kari Stefansson Kari E North Mark I McCarthy Joel N Hirschhorn Erik Ingelsson Ruth J F Loos

Nat Genet 2010 Nov 10;42(11):937-48. Epub 2010 Oct 10.

Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.

View Article

Download full-text PDF

Source
http://www.genome.gov/pages/research/dir/bmistudy.pdf
Web Search
http://www.nature.com/doifinder/10.1038/ng.686
Publisher Site
http://dx.doi.org/10.1038/ng.686DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014648PMC
November 2010

Hundreds of variants clustered in genomic loci and biological pathways affect human height.

Authors:
Hana Lango Allen Karol Estrada Guillaume Lettre Sonja I Berndt Michael N Weedon Fernando Rivadeneira Cristen J Willer Anne U Jackson Sailaja Vedantam Soumya Raychaudhuri Teresa Ferreira Andrew R Wood Robert J Weyant Ayellet V Segrè Elizabeth K Speliotes Eleanor Wheeler Nicole Soranzo Ju-Hyun Park Jian Yang Daniel Gudbjartsson Nancy L Heard-Costa Joshua C Randall Lu Qi Albert Vernon Smith Reedik Mägi Tomi Pastinen Liming Liang Iris M Heid Jian'an Luan Gudmar Thorleifsson Thomas W Winkler Michael E Goddard Ken Sin Lo Cameron Palmer Tsegaselassie Workalemahu Yurii S Aulchenko Asa Johansson M Carola Zillikens Mary F Feitosa Tõnu Esko Toby Johnson Shamika Ketkar Peter Kraft Massimo Mangino Inga Prokopenko Devin Absher Eva Albrecht Florian Ernst Nicole L Glazer Caroline Hayward Jouke-Jan Hottenga Kevin B Jacobs Joshua W Knowles Zoltán Kutalik Keri L Monda Ozren Polasek Michael Preuss Nigel W Rayner Neil R Robertson Valgerdur Steinthorsdottir Jonathan P Tyrer Benjamin F Voight Fredrik Wiklund Jianfeng Xu Jing Hua Zhao Dale R Nyholt Niina Pellikka Markus Perola John R B Perry Ida Surakka Mari-Liis Tammesoo Elizabeth L Altmaier Najaf Amin Thor Aspelund Tushar Bhangale Gabrielle Boucher Daniel I Chasman Constance Chen Lachlan Coin Matthew N Cooper Anna L Dixon Quince Gibson Elin Grundberg Ke Hao M Juhani Junttila Lee M Kaplan Johannes Kettunen Inke R König Tony Kwan Robert W Lawrence Douglas F Levinson Mattias Lorentzon Barbara McKnight Andrew P Morris Martina Müller Julius Suh Ngwa Shaun Purcell Suzanne Rafelt Rany M Salem Erika Salvi Serena Sanna Jianxin Shi Ulla Sovio John R Thompson Michael C Turchin Liesbeth Vandenput Dominique J Verlaan Veronique Vitart Charles C White Andreas Ziegler Peter Almgren Anthony J Balmforth Harry Campbell Lorena Citterio Alessandro De Grandi Anna Dominiczak Jubao Duan Paul Elliott Roberto Elosua Johan G Eriksson Nelson B Freimer Eco J C Geus Nicola Glorioso Shen Haiqing Anna-Liisa Hartikainen Aki S Havulinna Andrew A Hicks Jennie Hui Wilmar Igl Thomas Illig Antti Jula Eero Kajantie Tuomas O Kilpeläinen Markku Koiranen Ivana Kolcic Seppo Koskinen Peter Kovacs Jaana Laitinen Jianjun Liu Marja-Liisa Lokki Ana Marusic Andrea Maschio Thomas Meitinger Antonella Mulas Guillaume Paré Alex N Parker John F Peden Astrid Petersmann Irene Pichler Kirsi H Pietiläinen Anneli Pouta Martin Ridderstråle Jerome I Rotter Jennifer G Sambrook Alan R Sanders Carsten Oliver Schmidt Juha Sinisalo Jan H Smit Heather M Stringham G Bragi Walters Elisabeth Widen Sarah H Wild Gonneke Willemsen Laura Zagato Lina Zgaga Paavo Zitting Helene Alavere Martin Farrall Wendy L McArdle Mari Nelis Marjolein J Peters Samuli Ripatti Joyce B J van Meurs Katja K Aben Kristin G Ardlie Jacques S Beckmann John P Beilby Richard N Bergman Sven Bergmann Francis S Collins Daniele Cusi Martin den Heijer Gudny Eiriksdottir Pablo V Gejman Alistair S Hall Anders Hamsten Heikki V Huikuri Carlos Iribarren Mika Kähönen Jaakko Kaprio Sekar Kathiresan Lambertus Kiemeney Thomas Kocher Lenore J Launer Terho Lehtimäki Olle Melander Tom H Mosley Arthur W Musk Markku S Nieminen Christopher J O'Donnell Claes Ohlsson Ben Oostra Lyle J Palmer Olli Raitakari Paul M Ridker John D Rioux Aila Rissanen Carlo Rivolta Heribert Schunkert Alan R Shuldiner David S Siscovick Michael Stumvoll Anke Tönjes Jaakko Tuomilehto Gert-Jan van Ommen Jorma Viikari Andrew C Heath Nicholas G Martin Grant W Montgomery Michael A Province Manfred Kayser Alice M Arnold Larry D Atwood Eric Boerwinkle Stephen J Chanock Panos Deloukas Christian Gieger Henrik Grönberg Per Hall Andrew T Hattersley Christian Hengstenberg Wolfgang Hoffman G Mark Lathrop Veikko Salomaa Stefan Schreiber Manuela Uda Dawn Waterworth Alan F Wright Themistocles L Assimes Inês Barroso Albert Hofman Karen L Mohlke Dorret I Boomsma Mark J Caulfield L Adrienne Cupples Jeanette Erdmann Caroline S Fox Vilmundur Gudnason Ulf Gyllensten Tamara B Harris Richard B Hayes Marjo-Riitta Jarvelin Vincent Mooser Patricia B Munroe Willem H Ouwehand Brenda W Penninx Peter P Pramstaller Thomas Quertermous Igor Rudan Nilesh J Samani Timothy D Spector Henry Völzke Hugh Watkins James F Wilson Leif C Groop Talin Haritunians Frank B Hu Robert C Kaplan Andres Metspalu Kari E North David Schlessinger Nicholas J Wareham David J Hunter Jeffrey R O'Connell David P Strachan H-Erich Wichmann Ingrid B Borecki Cornelia M van Duijn Eric E Schadt Unnur Thorsteinsdottir Leena Peltonen André G Uitterlinden Peter M Visscher Nilanjan Chatterjee Ruth J F Loos Michael Boehnke Mark I McCarthy Erik Ingelsson Cecilia M Lindgren Gonçalo R Abecasis Kari Stefansson Timothy M Frayling Joel N Hirschhorn

Nature 2010 Oct 29;467(7317):832-8. Epub 2010 Sep 29.

Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter EX1 2LU, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature09410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955183PMC
October 2010

Genome wide association (GWA) predictors of anti-TNFalpha therapeutic responsiveness in pediatric inflammatory bowel disease.

Inflamm Bowel Dis 2010 Aug;16(8):1357-66

Department of Pediatrics and Medicine, Inflammatory Bowel Disease Program, Medical Genetics Institute, Cedars Sinai Medical Center, Los Angeles, California, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ibd.21174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889173PMC
August 2010

Biological, clinical and population relevance of 95 loci for blood lipids.

Authors:
Tanya M Teslovich Kiran Musunuru Albert V Smith Andrew C Edmondson Ioannis M Stylianou Masahiro Koseki James P Pirruccello Samuli Ripatti Daniel I Chasman Cristen J Willer Christopher T Johansen Sigrid W Fouchier Aaron Isaacs Gina M Peloso Maja Barbalic Sally L Ricketts Joshua C Bis Yurii S Aulchenko Gudmar Thorleifsson Mary F Feitosa John Chambers Marju Orho-Melander Olle Melander Toby Johnson Xiaohui Li Xiuqing Guo Mingyao Li Yoon Shin Cho Min Jin Go Young Jin Kim Jong-Young Lee Taesung Park Kyunga Kim Xueling Sim Rick Twee-Hee Ong Damien C Croteau-Chonka Leslie A Lange Joshua D Smith Kijoung Song Jing Hua Zhao Xin Yuan Jian'an Luan Claudia Lamina Andreas Ziegler Weihua Zhang Robert Y L Zee Alan F Wright Jacqueline C M Witteman James F Wilson Gonneke Willemsen H-Erich Wichmann John B Whitfield Dawn M Waterworth Nicholas J Wareham Gérard Waeber Peter Vollenweider Benjamin F Voight Veronique Vitart Andre G Uitterlinden Manuela Uda Jaakko Tuomilehto John R Thompson Toshiko Tanaka Ida Surakka Heather M Stringham Tim D Spector Nicole Soranzo Johannes H Smit Juha Sinisalo Kaisa Silander Eric J G Sijbrands Angelo Scuteri James Scott David Schlessinger Serena Sanna Veikko Salomaa Juha Saharinen Chiara Sabatti Aimo Ruokonen Igor Rudan Lynda M Rose Robert Roberts Mark Rieder Bruce M Psaty Peter P Pramstaller Irene Pichler Markus Perola Brenda W J H Penninx Nancy L Pedersen Cristian Pattaro Alex N Parker Guillaume Pare Ben A Oostra Christopher J O'Donnell Markku S Nieminen Deborah A Nickerson Grant W Montgomery Thomas Meitinger Ruth McPherson Mark I McCarthy Wendy McArdle David Masson Nicholas G Martin Fabio Marroni Massimo Mangino Patrik K E Magnusson Gavin Lucas Robert Luben Ruth J F Loos Marja-Liisa Lokki Guillaume Lettre Claudia Langenberg Lenore J Launer Edward G Lakatta Reijo Laaksonen Kirsten O Kyvik Florian Kronenberg Inke R König Kay-Tee Khaw Jaakko Kaprio Lee M Kaplan Asa Johansson Marjo-Riitta Jarvelin A Cecile J W Janssens Erik Ingelsson Wilmar Igl G Kees Hovingh Jouke-Jan Hottenga Albert Hofman Andrew A Hicks Christian Hengstenberg Iris M Heid Caroline Hayward Aki S Havulinna Nicholas D Hastie Tamara B Harris Talin Haritunians Alistair S Hall Ulf Gyllensten Candace Guiducci Leif C Groop Elena Gonzalez Christian Gieger Nelson B Freimer Luigi Ferrucci Jeanette Erdmann Paul Elliott Kenechi G Ejebe Angela Döring Anna F Dominiczak Serkalem Demissie Panagiotis Deloukas Eco J C de Geus Ulf de Faire Gabriel Crawford Francis S Collins Yii-der I Chen Mark J Caulfield Harry Campbell Noel P Burtt Lori L Bonnycastle Dorret I Boomsma S Matthijs Boekholdt Richard N Bergman Inês Barroso Stefania Bandinelli Christie M Ballantyne Themistocles L Assimes Thomas Quertermous David Altshuler Mark Seielstad Tien Y Wong E-Shyong Tai Alan B Feranil Christopher W Kuzawa Linda S Adair Herman A Taylor Ingrid B Borecki Stacey B Gabriel James G Wilson Hilma Holm Unnur Thorsteinsdottir Vilmundur Gudnason Ronald M Krauss Karen L Mohlke Jose M Ordovas Patricia B Munroe Jaspal S Kooner Alan R Tall Robert A Hegele John J P Kastelein Eric E Schadt Jerome I Rotter Eric Boerwinkle David P Strachan Vincent Mooser Kari Stefansson Muredach P Reilly Nilesh J Samani Heribert Schunkert L Adrienne Cupples Manjinder S Sandhu Paul M Ridker Daniel J Rader Cornelia M van Duijn Leena Peltonen Gonçalo R Abecasis Michael Boehnke Sekar Kathiresan

Nature 2010 Aug;466(7307):707-13

Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature09270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039276PMC
August 2010

New loci associated with kidney function and chronic kidney disease.

Authors:
Anna Köttgen Cristian Pattaro Carsten A Böger Christian Fuchsberger Matthias Olden Nicole L Glazer Afshin Parsa Xiaoyi Gao Qiong Yang Albert V Smith Jeffrey R O'Connell Man Li Helena Schmidt Toshiko Tanaka Aaron Isaacs Shamika Ketkar Shih-Jen Hwang Andrew D Johnson Abbas Dehghan Alexander Teumer Guillaume Paré Elizabeth J Atkinson Tanja Zeller Kurt Lohman Marilyn C Cornelis Nicole M Probst-Hensch Florian Kronenberg Anke Tönjes Caroline Hayward Thor Aspelund Gudny Eiriksdottir Lenore J Launer Tamara B Harris Evadnie Rampersaud Braxton D Mitchell Dan E Arking Eric Boerwinkle Maksim Struchalin Margherita Cavalieri Andrew Singleton Francesco Giallauria Jeffrey Metter Ian H de Boer Talin Haritunians Thomas Lumley David Siscovick Bruce M Psaty M Carola Zillikens Ben A Oostra Mary Feitosa Michael Province Mariza de Andrade Stephen T Turner Arne Schillert Andreas Ziegler Philipp S Wild Renate B Schnabel Sandra Wilde Thomas F Munzel Tennille S Leak Thomas Illig Norman Klopp Christa Meisinger H-Erich Wichmann Wolfgang Koenig Lina Zgaga Tatijana Zemunik Ivana Kolcic Cosetta Minelli Frank B Hu Asa Johansson Wilmar Igl Ghazal Zaboli Sarah H Wild Alan F Wright Harry Campbell David Ellinghaus Stefan Schreiber Yurii S Aulchenko Janine F Felix Fernando Rivadeneira Andre G Uitterlinden Albert Hofman Medea Imboden Dorothea Nitsch Anita Brandstätter Barbara Kollerits Lyudmyla Kedenko Reedik Mägi Michael Stumvoll Peter Kovacs Mladen Boban Susan Campbell Karlhans Endlich Henry Völzke Heyo K Kroemer Matthias Nauck Uwe Völker Ozren Polasek Veronique Vitart Sunita Badola Alexander N Parker Paul M Ridker Sharon L R Kardia Stefan Blankenberg Yongmei Liu Gary C Curhan Andre Franke Thierry Rochat Bernhard Paulweber Inga Prokopenko Wei Wang Vilmundur Gudnason Alan R Shuldiner Josef Coresh Reinhold Schmidt Luigi Ferrucci Michael G Shlipak Cornelia M van Duijn Ingrid Borecki Bernhard K Krämer Igor Rudan Ulf Gyllensten James F Wilson Jacqueline C Witteman Peter P Pramstaller Rainer Rettig Nick Hastie Daniel I Chasman W H Kao Iris M Heid Caroline S Fox

Nat Genet 2010 May 11;42(5):376-84. Epub 2010 Apr 11.

Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997674PMC
May 2010

A genome-wide association study of carotid atherosclerosis in HIV-infected men.

AIDS 2010 Feb;24(4):583-92

Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, 1665 University Blvd., Birmingham, AL 35294-0022, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/QAD.0b013e3283353c9eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072760PMC
February 2010

Susceptibility to Crohn's disease is mediated by KIR2DL2/KIR2DL3 heterozygosity and the HLA-C ligand.

Immunogenetics 2009 Oct 30;61(10):663-71. Epub 2009 Sep 30.

Center for Genetics, Children's Hospital Oakland Research Institute, 5700 Martin Luther King Jr. Way, Oakland, CA 94609, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00251-009-0396-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813946PMC
October 2009

Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data.

JAMA 2009 Jul;302(2):168-78

Framingham Heart Study, 73 Mt Wayte Ave, Ste 2, Framingham, MA 01702-5827, USA.

View Article

Download full-text PDF

Source
http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.20
Publisher Site
http://dx.doi.org/10.1001/jama.2009.978-aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2975567PMC
July 2009

Novel Gemini vitamin D(3) analogs have potent antitumor activity.

J Steroid Biochem Mol Biol 2008 Nov 30;112(1-3):151-6. Epub 2008 Sep 30.

Division of Hematology and Oncology, Cedars-Sinai Medical Center, UCLA School of Medicine, Los Angeles, CA 90048, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jsbmb.2008.09.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2648831PMC
November 2008

Novel acyl sulfonamide LY573636-sodium: effect on hematopoietic malignant cells.

Oncol Rep 2008 Nov;20(5):1237-42

Division of Hematology/Oncology, Cedars-Sinai Medical Center and UCLA School of Medicine, Los Angeles, CA 90048, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659324PMC
November 2008

Cucurbitacin B induces differentiation, cell cycle arrest, and actin cytoskeletal alterations in myeloid leukemia cells.

Leuk Res 2008 Sep 10;32(9):1366-73. Epub 2008 Apr 10.

Division of Hematology/Oncology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S014521260800053
Publisher Site
http://dx.doi.org/10.1016/j.leukres.2008.01.019DOI Listing
September 2008

Cucurbitacin B has a potent antiproliferative effect on breast cancer cells in vitro and in vivo.

Cancer Sci 2008 Sep 10;99(9):1793-7. Epub 2008 Jul 10.

Division of Hematology/Oncology, Cedars-Sinai Medical Center/University of California at Los Angeles, School of Medicine, California 90048, USA.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/j.1349-7006.2008.00899.x
Publisher Site
http://dx.doi.org/10.1111/j.1349-7006.2008.00899.xDOI Listing
September 2008

Lipoprotein lipase locus and progression of atherosclerosis in coronary-artery bypass grafts.

Genet Med 2004 Nov-Dec;6(6):481-6

Medical Genetics Institute, and Division of Cardiology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.

View Article

Download full-text PDF

Source
February 2005