Takeshi Sakurai

Takeshi Sakurai

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Cognitive functions associated with developing prefrontal cortex during adolescence and developmental neuropsychiatric disorders.

Neurobiol Dis 2019 Nov 10;131:104322. Epub 2018 Nov 10.

Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S09699961183074
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http://dx.doi.org/10.1016/j.nbd.2018.11.007DOI Listing
November 2019

Editorial for "What can clinical findings tell us about the neurobiology of schizophrenia? Revisited".

Neurobiol Dis 2019 Nov 9;131:104521. Epub 2019 Jul 9.

Departments of Psychiatry, Neuroscience, Biomedical Engineering, Mental Health, Genetic Medicine, Johns Hopkins University School of Medicine and Bloomberg School of Public Health, Baltimore, MD, USA.

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http://dx.doi.org/10.1016/j.nbd.2019.104521DOI Listing
November 2019

Do remittances alleviate negative impacts of disaster on mental health? A case of the 2015 Nepal earthquake.

Soc Sci Med 2019 Oct 1;238:112460. Epub 2019 Aug 1.

School of Public Health, University of California, Berkeley, CA, USA.

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http://dx.doi.org/10.1016/j.socscimed.2019.112460DOI Listing
October 2019

Narcolepsy - clinical spectrum, aetiopathophysiology, diagnosis and treatment.

Nat Rev Neurol 2019 Sep 19;15(9):519-539. Epub 2019 Jul 19.

Sleep-Wake Disorders Center, Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier, University of Montpellier, Montpellier, France.

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http://dx.doi.org/10.1038/s41582-019-0226-9DOI Listing
September 2019

Miniaturized microscope with flexible light source input for neuronal imaging and manipulation in freely behaving animals.

Biochem Biophys Res Commun 2019 Sep 31;517(3):520-524. Epub 2019 Jul 31.

International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-0006, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2019.07.082DOI Listing
September 2019

Activation of lateral hypothalamic group III metabotropic glutamate receptors suppresses cocaine-seeking following abstinence and normalizes drug-associated increases in excitatory drive to orexin/hypocretin cells.

Neuropharmacology 2019 Aug 22;154:22-33. Epub 2018 Sep 22.

School of Biomedical Sciences & Pharmacy, Centre for Brain and Mental Health Research, Hunter Medical Research Institute, University of Newcastle, 2308, NSW, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2018.09.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520213PMC
August 2019

[Neural circuitry and brain functions.]

Clin Calcium 2018;28(6):844-850

Medical Innovation Center Kyoto University Graduate School of Medicine, Japan.

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http://dx.doi.org/CliCa1806844850DOI Listing
June 2019

Optogenetic Manipulation of Neural Circuits During Monitoring Sleep/wakefulness States in Mice.

J Vis Exp 2019 Jun 19(148). Epub 2019 Jun 19.

International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba; Faculty of Medicine, University of Tsukuba;

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http://dx.doi.org/10.3791/58613DOI Listing
June 2019

Analysis of the role of wind information for efficient chemical plume tracing based on optogenetic silkworm moth behavior.

Bioinspir Biomim 2019 05 31;14(4):046006. Epub 2019 May 31.

Department of System Innovation, Osaka University, 1-2 Machikaneyama-cho, Toyonaka, Osaka, 560-8531, Japan. Author to whom correspondence may be addressed.

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http://iopscience.iop.org/article/10.1088/1748-3190/ab1d34
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http://dx.doi.org/10.1088/1748-3190/ab1d34DOI Listing
May 2019

Neuronal cell adhesion molecule regulating neural systems underlying addiction.

Neuropsychopharmacol Rep 2019 Mar 13;39(1):10-16. Epub 2018 Dec 13.

Department of Biology, William Paterson University, Wayne, New Jersey.

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http://dx.doi.org/10.1002/npr2.12038DOI Listing
March 2019

Memory consolidation during sleep and adult hippocampal neurogenesis.

Neural Regen Res 2019 Jan;14(1):20-23

International Institute for Integrative Sleep Medicine, University of Tsukuba, Tsukuba, Japan.

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http://dx.doi.org/10.4103/1673-5374.243695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263001PMC
January 2019

Redox Potential-Dependent Formation of an Unusual His-Trp Bond in Bilirubin Oxidase.

Chemistry 2018 Dec 15;24(68):18052-18058. Epub 2018 Nov 15.

Department of Picobiology, Graduate School of Life Science, University of Hyogo, 3-2-1 Koto, Kamigori-cho, Ako-gun, Hyogo, 678-1297, Japan.

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http://dx.doi.org/10.1002/chem.201803798DOI Listing
December 2018

Structural Changes of the Trinuclear Copper Center in Bilirubin Oxidase upon Reduction.

Molecules 2018 Dec 26;24(1). Epub 2018 Dec 26.

Department of Chemistry, Graduate School of Science, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-8578, Japan.

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http://www.mdpi.com/1420-3049/24/1/76
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http://dx.doi.org/10.3390/molecules24010076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337666PMC
December 2018

Neuron-related blood inflammatory markers as an objective evaluation tool for major depressive disorder: An exploratory pilot case-control study.

J Affect Disord 2018 11 17;240:88-98. Epub 2018 Jul 17.

Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan.

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http://dx.doi.org/10.1016/j.jad.2018.07.040DOI Listing
November 2018

Sleep and Wakefulness Are Controlled by Ventral Medial Midbrain/Pons GABAergic Neurons in Mice.

J Neurosci 2018 Nov 3;38(47):10080-10092. Epub 2018 Oct 3.

International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan

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http://www.jneurosci.org/lookup/doi/10.1523/JNEUROSCI.0598-1
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http://dx.doi.org/10.1523/JNEUROSCI.0598-18.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6596202PMC
November 2018

Characterizing vulnerable brain areas and circuits in mouse models of autism: Towards understanding pathogenesis and new therapeutic approaches.

Neurosci Biobehav Rev 2018 Nov 21. Epub 2018 Nov 21.

Medical Innovation Center Kyoto University Graduate School of Medicine, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.neubiorev.2018.08.001DOI Listing
November 2018

Orexin as a modulator of fear-related behavior: Hypothalamic control of noradrenaline circuit.

Brain Res 2018 Nov 24. Epub 2018 Nov 24.

International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan; Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan; Life Science Center for Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.brainres.2018.11.032DOI Listing
November 2018

Serotonergic Input to Orexin Neurons Plays a Role in Maintaining Wakefulness and REM Sleep Architecture.

Front Neurosci 2018 30;12:892. Epub 2018 Nov 30.

International Institute for Integrative Sleep Medicine, University of Tsukuba, Tsukuba, Japan.

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http://dx.doi.org/10.3389/fnins.2018.00892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284013PMC
November 2018

In vivo functional characterisation of pheromone binding protein-1 in the silkmoth, Bombyx mori.

Sci Rep 2018 Sep 10;8(1):13529. Epub 2018 Sep 10.

Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo, 153-8904, Japan.

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http://dx.doi.org/10.1038/s41598-018-31978-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131395PMC
September 2018

A mouse model of 22q11.2 deletions: Molecular and behavioral signatures of Parkinson's disease and schizophrenia.

Sci Adv 2018 08 15;4(8):eaar6637. Epub 2018 Aug 15.

Department of Research and Drug Discovery, Medical Innovation Center, Kyoto University Graduate School of Medicine, Kyoto, Japan.

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http://dx.doi.org/10.1126/sciadv.aar6637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093626PMC
August 2018

Concise Review: Regulatory Influence of Sleep and Epigenetics on Adult Hippocampal Neurogenesis and Cognitive and Emotional Function.

Stem Cells 2018 07 9;36(7):969-976. Epub 2018 Mar 9.

International Institute for Integrative Sleep Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.

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http://dx.doi.org/10.1002/stem.2815DOI Listing
July 2018

Monoamines Inhibit GABAergic Neurons in Ventrolateral Preoptic Area That Make Direct Synaptic Connections to Hypothalamic Arousal Neurons.

J Neurosci 2018 Jul 18;38(28):6366-6378. Epub 2018 Jun 18.

International Institute for Integrative Sleep Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan,

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http://dx.doi.org/10.1523/JNEUROSCI.2835-17.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6596100PMC
July 2018

Hypocretin/orexin deficiency decreases cocaine abuse liability.

Neuropharmacology 2018 05 15;133:395-403. Epub 2018 Feb 15.

Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, Switzerland; Division of Adolescent and Child Psychiatry, Department of Psychiatry, Lausanne University Hospital, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2018.02.010DOI Listing
May 2018

Methylphenidate and Guanfacine Ameliorate ADHD-Like Phenotypes in -Deficient Mice.

Mol Neuropsychiatry 2018 May 26;3(4):223-233. Epub 2018 Apr 26.

Department of Research and Drug Discovery, Medical Innovation Center, Kyoto University Graduate School of Medicine, Kyoto, Japan.

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http://dx.doi.org/10.1159/000488081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5981631PMC
May 2018

Increasing cell-device adherence using cultured insect cells for receptor-based biosensors.

R Soc Open Sci 2018 Mar 21;5(3):172366. Epub 2018 Mar 21.

Research Center for Advanced Science and Technology (RCAST), The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo, Japan.

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http://dx.doi.org/10.1098/rsos.172366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882746PMC
March 2018

Orexin modulates behavioral fear expression through the locus coeruleus.

Nat Commun 2017 11 20;8(1):1606. Epub 2017 Nov 20.

International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai Tsukuba, Ibaraki, 305-8575, Japan.

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http://dx.doi.org/10.1038/s41467-017-01782-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5694764PMC
November 2017

Circuitry-Based Human Neuroanatomy for the Next Generation in Psychiatry and Neuroscience.

Authors:
Takeshi Sakurai

Mol Neuropsychiatry 2017 Nov 7;3(2):92-96. Epub 2017 Sep 7.

Department of Drug Discovery Medicine, Medical Innovation Center, Kyoto University Graduate School of Medicine, Kyoto, Japan.

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http://dx.doi.org/10.1159/000479514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701289PMC
November 2017

Orexin Receptor Multimerization versus Functional Interactions: Neuropharmacological Implications for Opioid and Cannabinoid Signalling and Pharmacogenetics.

Pharmaceuticals (Basel) 2017 10 8;10(4). Epub 2017 Oct 8.

Biochemistry and Cell Biology, Department of Veterinary Biosciences, University of Helsinki, Helsinki 11739, Finland.

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http://dx.doi.org/10.3390/ph10040079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748636PMC
October 2017

Refinement of ectopic protein expression through the GAL4/UAS system in Bombyx mori: application to behavioral and developmental studies.

Sci Rep 2017 09 18;7(1):11795. Epub 2017 Sep 18.

Division of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa, 920-1192, Japan.

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http://dx.doi.org/10.1038/s41598-017-12102-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603595PMC
September 2017

Amino acids located in the outer-sphere of the trinuclear copper center in a multicopper oxidase, CueO as the putative electron donor in the four-electron reduction of dioxygen.

Biochim Biophys Acta Proteins Proteom 2017 Aug 1;1865(8):997-1003. Epub 2017 May 1.

Graduate School of Natural Science and Technology, Kanazawa University, Kakuma, Kanazawa 920-1192, Japan.

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http://dx.doi.org/10.1016/j.bbapap.2017.04.005DOI Listing
August 2017

Excitation of GABAergic Neurons in the Bed Nucleus of the Stria Terminalis Triggers Immediate Transition from Non-Rapid Eye Movement Sleep to Wakefulness in Mice.

J Neurosci 2017 07 22;37(30):7164-7176. Epub 2017 Jun 22.

Department of Molecular Neuroscience and Integrative Physiology, Faculty of Medicine, Kanazawa University, Kanazawa, Ishikawa 920-8640, Japan,

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http://dx.doi.org/10.1523/JNEUROSCI.0245-17.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6705739PMC
July 2017

Role of DISC1 in Neuronal Trafficking and its Implication in Neuropsychiatric Manifestation and Neurotherapeutics.

Neurotherapeutics 2017 Jul;14(3):623-629

Medical Innovation Center, Kyoto University Graduate School of Medicine, Kyoto, Japan.

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http://dx.doi.org/10.1007/s13311-017-0556-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509643PMC
July 2017

The role of cell adhesion molecules in brain wiring and neuropsychiatric disorders.

Authors:
Takeshi Sakurai

Mol Cell Neurosci 2017 06 22;81:4-11. Epub 2016 Aug 22.

Medical Innovation Center, Kyoto University Graduate School of Medicine, 53 Shogoin Kawaharacho, Sakyo-ku, Kyoto, 606-8507, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.mcn.2016.08.005DOI Listing
June 2017

Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models.

Proc Natl Acad Sci U S A 2017 05 15;114(22):5731-5736. Epub 2017 May 15.

International Institute for Integrative Sleep Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan

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http://dx.doi.org/10.1073/pnas.1700499114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5465922PMC
May 2017

Ulk1 protects against ethanol-induced neuronal stress and cognition-related behavioral deficits.

Neurosci Res 2017 Apr 23;117:54-61. Epub 2016 Dec 23.

Kyoto University Graduate School of Medicine, Medical Innovation Center, Kyoto, Japan; University of Toronto, Centre for Addiction and Mental Health, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.neures.2016.12.004DOI Listing
April 2017

Heterologous expression of Halomonas halodenitrificans nitric oxide reductase and its N-terminally truncated NorC subunit in Escherichia coli.

J Inorg Biochem 2017 04 21;169:61-67. Epub 2017 Jan 21.

Division of Material Science, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma, Kanazawa 920-1192, Japan.

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http://dx.doi.org/10.1016/j.jinorgbio.2017.01.006DOI Listing
April 2017

Serotonin neurons in the dorsal raphe mediate the anticataplectic action of orexin neurons by reducing amygdala activity.

Proc Natl Acad Sci U S A 2017 04 10;114(17):E3526-E3535. Epub 2017 Apr 10.

Department of Molecular Neuroscience and Integrative Physiology, Graduate School of Medical Sciences, Kanazawa University, Kanazawa 920-8640, Japan;

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http://dx.doi.org/10.1073/pnas.1614552114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410844PMC
April 2017

Auditory conditioned stimulus presentation during NREM sleep impairs fear memory in mice.

Sci Rep 2017 04 12;7:46247. Epub 2017 Apr 12.

International Institute for Integrative Sleep Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.

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http://dx.doi.org/10.1038/srep46247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388892PMC
April 2017

Valley of death: A proposal to build a "translational bridge" for the next generation.

Neurosci Res 2017 Feb 19;115:1-4. Epub 2016 Nov 19.

Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States. Electronic address:

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http://dx.doi.org/10.1016/j.neures.2016.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477974PMC
February 2017

Fine-Tuning Circadian Rhythms: The Importance of Expression in the Ventral Forebrain.

Front Neurosci 2017 9;11:55. Epub 2017 Feb 9.

Department of Molecular Neuroscience and Integrative Physiology, Graduate School of Medical Sciences, Kanazawa University Kanazawa, Japan.

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http://dx.doi.org/10.3389/fnins.2017.00055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299009PMC
February 2017

Kinetics of NADP/NADPH reduction-oxidation catalyzed by the ferredoxin-NAD(P) reductase from the green sulfur bacterium Chlorobaculum tepidum.

Photosynth Res 2016 Dec 24;130(1-3):479-489. Epub 2016 Jun 24.

Department of Biological Sciences, Kanagawa University, Tsuchiya, Hiratsuka, Kanagawa, 259-1293, Japan.

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http://dx.doi.org/10.1007/s11120-016-0285-3DOI Listing
December 2016

A novel method for full locomotion compensation of an untethered walking insect.

Bioinspir Biomim 2016 12 6;12(1):016005. Epub 2016 Dec 6.

Department of Mechanical and Control Engineering, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8552, Japan.

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http://dx.doi.org/10.1088/1748-3190/12/1/016005DOI Listing
December 2016

Timed Inhibition of Orexin System by Suvorexant Improved Sleep and Glucose Metabolism in Type 2 Diabetic db/db Mice.

Endocrinology 2016 Nov 15;157(11):4146-4157. Epub 2016 Sep 15.

Departments of Clinical Pharmacology (H.T., K.K., T.W., T.Sas.) and Anesthesiology (H.I., M.Yam.), Graduate School of Science and Technology, and Graduate School of Innovative Life Science (S.T., N.T.), and Department of Pathology (Y.I., M.S.), University of Toyama, Toyama 930-0194, Japan; and International Institute for Integrative Sleep Medicine (WPI-IIIS) (M.Yan., T.Sak.), University of Tsukuba, Tsukuba 305-8575, Japan.

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http://dx.doi.org/10.1210/en.2016-1404DOI Listing
November 2016

Odour-induced analgesia mediated by hypothalamic orexin neurons in mice.

Sci Rep 2016 11 15;6:37129. Epub 2016 Nov 15.

Department of Physiology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan.

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http://dx.doi.org/10.1038/srep37129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109046PMC
November 2016

Biochemical, spectroscopic and X-ray structural analysis of deuterated multicopper oxidase CueO prepared from a new expression construct for neutron crystallography.

Acta Crystallogr F Struct Biol Commun 2016 10 22;72(Pt 10):788-794. Epub 2016 Sep 22.

Department of Life Science, Graduate School of Life Science, University of Hyogo, 3-2-1 Koto, Kamigori, Ako-gun, Hyogo 678-1297, Japan.

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http://dx.doi.org/10.1107/S2053230X1601400XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053165PMC
October 2016

Sleep Control, GPCRs, and Glucose Metabolism.

Trends Endocrinol Metab 2016 09 22;27(9):633-642. Epub 2016 Jul 22.

International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.tem.2016.06.011DOI Listing
September 2016

Manipulating the Cellular Circadian Period of Arginine Vasopressin Neurons Alters the Behavioral Circadian Period.

Curr Biol 2016 09 25;26(18):2535-2542. Epub 2016 Aug 25.

Department of Molecular Neuroscience and Integrative Physiology, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa 920-8640, Japan.

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http://dx.doi.org/10.1016/j.cub.2016.07.022DOI Listing
September 2016

Exogenous acetate ion reaches the type II copper centre in CueO through the water-excretion channel and potentially affects the enzymatic activity.

Acta Crystallogr F Struct Biol Commun 2016 07 22;72(Pt 7):558-63. Epub 2016 Jun 22.

Graduate School of Natural Science and Technology, Kanazawa University, Kakuma, Kanazawa, Ishikawa 920-1192, Japan.

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http://dx.doi.org/10.1107/S2053230X16009237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933006PMC
July 2016

Cell-Based Odorant Sensor Array for Odor Discrimination Based on Insect Odorant Receptors.

J Chem Ecol 2016 Jul 16;42(7):716-24. Epub 2016 Jul 16.

Graduate School of Information Science and Technology, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.

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http://dx.doi.org/10.1007/s10886-016-0726-7DOI Listing
July 2016

Pre-steady-state kinetic studies of redox reactions catalysed by Bacillus subtilis ferredoxin-NADP(+) oxidoreductase with NADP(+)/NADPH and ferredoxin.

Biochim Biophys Acta 2016 Jun 8;1857(6):678-87. Epub 2016 Mar 8.

Division of Material Science, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma, Kanazawa, Ishikawa 920-1192, Japan.

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http://dx.doi.org/10.1016/j.bbabio.2016.03.005DOI Listing
June 2016

Mesolimbic neuropeptide W coordinates stress responses under novel environments.

Proc Natl Acad Sci U S A 2016 May 2;113(21):6023-8. Epub 2016 May 2.

Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390; Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390; Exploratory Research for Advanced Technology, Yanagisawa Orphan Receptor Project, Japan Science and Technology Agency, Tokyo 135-0064, Japan; International Institute for Integrative Sleep Medicine, University of Tsukuba, Tsukuba 305-8575, Japan

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http://dx.doi.org/10.1073/pnas.1518658113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889355PMC
May 2016

Messenger RNA expression profile of sleep-related genes in peripheral blood cells in patients with chronic kidney disease.

Clin Exp Nephrol 2016 Apr 20;20(2):218-25. Epub 2015 Sep 20.

Division of Nephrology, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa, 920-8641, Japan.

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http://dx.doi.org/10.1007/s10157-015-1150-yDOI Listing
April 2016

Identification of repellent odorants to the body louse, Pediculus humanus corporis, in clove essential oil.

Parasitol Res 2016 Apr 11;115(4):1659-66. Epub 2016 Feb 11.

Department of Advanced Interdisciplinary Studies, Graduate School of Engineering, The University of Tokyo, Komaba 4-6-1, Meguro-ku, Tokyo, 153-8904, Japan.

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http://dx.doi.org/10.1007/s00436-016-4905-9DOI Listing
April 2016

Nighttime Administration of Nicotine Improves Hepatic Glucose Metabolism via the Hypothalamic Orexin System in Mice.

Endocrinology 2016 Jan 22;157(1):195-206. Epub 2015 Oct 22.

Department of Clinical Pharmacology (H.T., T.N., M.F., K.K., N.W., M.T., K.Y., T.W., T.Sas.) and System Emotional Science (H.N.), University of Toyama, Toyama 930-0194, Japan; International Institute for Integrative Sleep Medicine (WPI-IIIS) (M.Y.), University of Tsukuba, Tsukuba 305-8575, Japan; Department of Molecular Genetics (M.Y.), University of Texas Southwestern Medical Center, Dallas, Texas 75390; and Department of Molecular Neuroscience and Integrative Physiology (T.Sak.), Faculty of Medicine, Kanazawa University, Kanazawa, Ishikawa 920-8640, Japan.

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http://dx.doi.org/10.1210/en.2015-1488DOI Listing
January 2016

Comprehensive Behavioral Analysis of Male Ox1r (-/-) Mice Showed Implication of Orexin Receptor-1 in Mood, Anxiety, and Social Behavior.

Front Behav Neurosci 2015 10;9:324. Epub 2015 Dec 10.

Department of Molecular Neuroscience and Integrative Physiology, Faculty of Medicine, Kanazawa University Kanazawa, Japan ; International Institute for Integrative Sleep Medicine, University of Tsukuba Tsukuba, Japan.

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http://dx.doi.org/10.3389/fnbeh.2015.00324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674555PMC
December 2015

Converging models of schizophrenia--Network alterations of prefrontal cortex underlying cognitive impairments.

Prog Neurobiol 2015 Nov 25;134:178-201. Epub 2015 Sep 25.

Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, USA.

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http://dx.doi.org/10.1016/j.pneurobio.2015.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4656070PMC
November 2015

A pirin-like protein from and its quercetinase activity.

Biochem Biophys Rep 2015 Sep 7;3:144-149. Epub 2015 Aug 7.

Graduate School of Natural Science and Technology, Kanazawa University, Kakuma, Kanazawa 920-1192, Japan.

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http://dx.doi.org/10.1016/j.bbrep.2015.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668851PMC
September 2015

Hypocretin/orexin prevents recovery from sickness.

Biomed Rep 2015 Sep 17;3(5):648-650. Epub 2015 Jul 17.

Sleep Disorders Project, Department of Psychiatry and Behavioral Science, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan.

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http://dx.doi.org/10.3892/br.2015.491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534883PMC
September 2015

Replacement of Tyr50 stacked on the si-face of the isoalloxazine ring of the flavin adenine dinucleotide prosthetic group modulates Bacillus subtilis ferredoxin-NADP(+) oxidoreductase activity toward NADPH.

Photosynth Res 2015 Aug 20;125(1-2):321-8. Epub 2015 Feb 20.

Division of Material Science, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma, Kanazawa, Ishikawa, 920-1192, Japan,

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http://dx.doi.org/10.1007/s11120-015-0099-8DOI Listing
August 2015

A novel resting form of the trinuclear copper center in the double mutant of a multicopper oxidase, CueO, Cys500Ser/Glu506Ala.

J Inorg Biochem 2015 Aug 24;149:88-90. Epub 2015 Mar 24.

Graduate School of Natural Science and Technology, Kanazawa University, Kakuma, Kanazawa 920-1192, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jinorgbio.2015.03.005DOI Listing
August 2015

Sequence of Molecular Events during the Maturation of the Developing Mouse Prefrontal Cortex.

Mol Neuropsychiatry 2015 Jul 9;1(2):94-104. Epub 2015 Jun 9.

Medical Innovation Center, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan.

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http://dx.doi.org/10.1159/000430095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596535PMC
July 2015

Targeted disruption of a single sex pheromone receptor gene completely abolishes in vivo pheromone response in the silkmoth.

Sci Rep 2015 Jun 5;5:11001. Epub 2015 Jun 5.

Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan.

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http://dx.doi.org/10.1038/srep11001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457163PMC
June 2015

[Roles of orexin and effects of orexin receptor antagonists].

Authors:
Takeshi Sakurai

Nihon Rinsho 2015 Jun;73(6):1023-30

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June 2015

Roles of orexins in the regulation of body weight homeostasis.

Authors:
Takeshi Sakurai

Obes Res Clin Pract 2014 Sep-Oct;8(5):e414-20. Epub 2013 Dec 28.

Department of Molecular Neuroscience and Integrative Physiology, Faculty of Medicine, Kanazawa University, 13-1 Takaramachi, Kanazawa-shi, Ishikawa 920-8640, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.orcp.2013.12.001DOI Listing
May 2015

Novel cell-based odorant sensor elements based on insect odorant receptors.

Biosens Bioelectron 2015 Mar 17;65:287-94. Epub 2014 Oct 17.

Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan; Graduate School of Information Science and Technology, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bios.2014.10.026DOI Listing
March 2015

Cellular clocks in AVP neurons of the SCN are critical for interneuronal coupling regulating circadian behavior rhythm.

Neuron 2015 Mar;85(5):1103-16

Department of Molecular Neuroscience and Integrative Physiology, Faculty of Medicine, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa 920-8640, Japan.

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http://dx.doi.org/10.1016/j.neuron.2015.02.005DOI Listing
March 2015

[Central regulation of feeding behavior].

Authors:
Takeshi Sakurai

Brain Nerve 2015 Feb;67(2):131-9

Department of Molecular Neuroscience and Integrative Physiology, Faculty of Medicine, Kanazawa University.

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http://dx.doi.org/10.11477/mf.1416200106DOI Listing
February 2015

Odorant concentration differentiator for intermittent olfactory signals.

J Neurosci 2014 Dec;34(50):16581-93

Graduate School of Information Science and Technology, University of Tokyo, Tokyo, 113-8656, Japan, Research Center for Advanced Science and Technology, University of Tokyo, Tokyo, 153-8904, Japan,

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http://dx.doi.org/10.1523/JNEUROSCI.2319-14.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6608502PMC
December 2014

The role of orexin in motivated behaviours.

Authors:
Takeshi Sakurai

Nat Rev Neurosci 2014 Nov 10;15(11):719-31. Epub 2014 Oct 10.

Department of Molecular Neuroscience and Integrative Physiology, Faculty of Medicine, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa 920-8640, Japan.

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http://dx.doi.org/10.1038/nrn3837DOI Listing
November 2014

Role of the C-terminal extension stacked on the re-face of the isoalloxazine ring moiety of the flavin adenine dinucleotide prosthetic group in ferredoxin-NADP(+) oxidoreductase from Bacillus subtilis.

Plant Physiol Biochem 2014 Aug 30;81:143-8. Epub 2014 Jan 30.

Division of Material Science, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma, Kanazawa, Ishikawa 920-1192, Japan.

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http://dx.doi.org/10.1016/j.plaphy.2014.01.011DOI Listing
August 2014

Introduction of the human AVPR1A gene substantially alters brain receptor expression patterns and enhances aspects of social behavior in transgenic mice.

Dis Model Mech 2014 Aug 12;7(8):1013-22. Epub 2014 Jun 12.

Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA Friedman Brain Institute and Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA

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http://dmm.biologists.org/cgi/doi/10.1242/dmm.017053
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http://dx.doi.org/10.1242/dmm.017053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107330PMC
August 2014

Study on dioxygen reduction by mutational modifications of the hydrogen bond network leading from bulk water to the trinuclear copper center in bilirubin oxidase.

Biochem Biophys Res Commun 2014 Jul 19;450(1):767-72. Epub 2014 Jun 19.

Graduate School of Natural Science and Technology, Kanazawa University, Kakuma, Kanazawa 920-1192, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2014.06.052DOI Listing
July 2014

Molecular and neural mechanisms of sex pheromone reception and processing in the silkmoth Bombyx mori.

Front Physiol 2014 31;5:125. Epub 2014 Mar 31.

Intelligent Cooperative Systems, Research Center for Advanced Science and Technology, The University of Tokyo Meguro-ku, Japan.

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http://dx.doi.org/10.3389/fphys.2014.00125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978319PMC
June 2014

OX1 and OX2 orexin/hypocretin receptor pharmacogenetics.

Front Neurosci 2014 6;8:57. Epub 2014 May 6.

Biochemistry and Cell Biology, Department of Veterinary Biosciences, University of Helsinki Helsinki, Finland.

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http://dx.doi.org/10.3389/fnins.2014.00057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018553PMC
June 2014

Coreleased orexin and glutamate evoke nonredundant spike outputs and computations in histamine neurons.

Cell Rep 2014 May 24;7(3):697-704. Epub 2014 Apr 24.

Division of Neurophysiology, MRC National Institute for Medical Research, London NW7 1AA, UK; MRC Centre for Developmental Neurobiology, King's College London, London WC2R 2LS, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247140025
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http://dx.doi.org/10.1016/j.celrep.2014.03.055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022832PMC
May 2014

Conditional ablation of orexin/hypocretin neurons: a new mouse model for the study of narcolepsy and orexin system function.

J Neurosci 2014 May;34(19):6495-509

Research Institute of Environmental Medicine, Nagoya University, Nagoya, 464-8601, Japan, Department of Physiological Sciences, The Graduate University for Advanced Studies, Okazaki 444-8585, Japan, Japan Society for the Promotion of Science, Tokyo 102-8472, Japan, Center for Neuroscience, Biosciences Division, SRI International, Menlo Park, California 94025, Division of Cell Signaling, National Institute for Physiological Sciences, National Institute of Natural Sciences, Okazaki 444-8787, Japan, Center for Multidisciplinary Brain Research, National Institute for Physiological Sciences, National Institute of Natural Sciences, Okazaki 444-8585, Japan, Division of Endocrinology and Metabolism, National Institute for Physiological Sciences, National Institute of Natural Sciences, Okazaki 444-8585, Japan, and Department of Molecular Neuroscience and Integrative Physiology, Faculty of Medicine, Kanazawa University, Kanazawa, Ishikawa 920-8640, Japan.

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http://dx.doi.org/10.1523/JNEUROSCI.0073-14.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012309PMC
May 2014

GABAergic neurons in the preoptic area send direct inhibitory projections to orexin neurons.

Front Neural Circuits 2013 2;7:192. Epub 2013 Dec 2.

Department of Molecular Neuroscience and Integrative Physiology, Faculty of Medicine, Kanazawa University Kanazawa, Japan.

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http://dx.doi.org/10.3389/fncir.2013.00192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844858PMC
April 2014

The scaffold protein JLP plays a key role in regulating ultraviolet B-induced apoptosis in mice.

Genes Cells 2014 Apr 12;19(4):350-8. Epub 2014 Feb 12.

Division of Molecular Cell Signaling, Cancer Research Institute, Kanazawa University, Kanazawa, 920-1192, Japan.

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http://doi.wiley.com/10.1111/gtc.12135
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http://dx.doi.org/10.1111/gtc.12135DOI Listing
April 2014

Giant vesicles functionally expressing membrane receptors for an insect pheromone.

Chem Commun (Camb) 2014 Mar 7;50(22):2958-61. Epub 2014 Feb 7.

Department of Applied Chemistry and Biotechnology, Graduate School of Engineering, Chiba University, 1-33 Yayoi, Inage, Chiba, Chiba 263-8522, Japan.

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http://dx.doi.org/10.1039/c3cc48216bDOI Listing
March 2014

New insights into the catalytic active-site structure of multicopper oxidases.

Acta Crystallogr D Biol Crystallogr 2014 Mar 22;70(Pt 3):772-9. Epub 2014 Feb 22.

Graduate School of Natural Science and Technology, Kanazawa University, Kakuma, Kanazawa 920-1192, Japan.

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http://dx.doi.org/10.1107/S1399004713033051DOI Listing
March 2014

Effects of a newly developed potent orexin-2 receptor-selective antagonist, compound 1 m, on sleep/wakefulness states in mice.

Front Neurosci 2014 31;8. Epub 2014 Jan 31.

Department of Molecular Neuroscience and Integrative Physiology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University Kanazawa, Japan.

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http://dx.doi.org/10.3389/fnins.2014.00008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907770PMC
February 2014

Orexin neurons are indispensable for prostaglandin E2-induced fever and defence against environmental cooling in mice.

J Physiol 2013 Nov 19;591(22):5623-43. Epub 2013 Aug 19.

T. Kuwaki: Department of Physiology, Kagoshima University Graduate School of Medical and Dental Sciences, Sakuragaoka 8-35-1, Kagoshima 890-8544, Japan.

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http://dx.doi.org/10.1113/jphysiol.2013.261271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3853500PMC
November 2013

Crystal structure of the CueO mutants at Glu506, the key amino acid located in the proton transfer pathway for dioxygen reduction.

Biochem Biophys Res Commun 2013 Sep 8;438(4):686-90. Epub 2013 Aug 8.

Faculty of Education, Kagawa University, 1-1 Saiwai, Takamatsu 760-8522, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2013.07.121DOI Listing
September 2013

Orexin receptor-1 in the locus coeruleus plays an important role in cue-dependent fear memory consolidation.

J Neurosci 2013 Sep;33(36):14549-57

Department of Molecular Neuroscience and Integrative Physiology, Faculty of Medicine, Kanazawa University, Kanazawa, Ishikawa 920-8640, Japan.

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http://dx.doi.org/10.1523/JNEUROSCI.1130-13.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6618384PMC
September 2013

Pheromone responsiveness threshold depends on temporal integration by antennal lobe projection neurons.

Proc Natl Acad Sci U S A 2013 Sep 4;110(38):15455-60. Epub 2013 Sep 4.

Department of Advanced Interdisciplinary Studies, Graduate School of Engineering, and Research Center for Advanced Science and Technology, University of Tokyo, Meguro-ku, Tokyo 153-8904, Japan.

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http://dx.doi.org/10.1073/pnas.1313707110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3780863PMC
September 2013

[Drug development targeting synaptic molecules - autism mouse models as an example].

Authors:
Takeshi Sakurai

Nihon Yakurigaku Zasshi 2013 Sep;142(3):116-21

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http://dx.doi.org/10.1254/fpj.142.116DOI Listing
September 2013

Deficiency of p62/Sequestosome 1 causes hyperphagia due to leptin resistance in the brain.

J Neurosci 2013 Sep;33(37):14767-77

Majors of Medical Sciences, University of Tsukuba, Ibaraki 305-8575, Japan, Department of Molecular Neuroscience and Integrative Physiology, Faculty of Medicine, Kanazawa University, Kanazawa, Ishikawa 920-8640, Japan, Center for Behavioral Molecular Genetics, University of Tsukuba, Ibaraki 305-8575, Japan, Department of Neurology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, Yonago, Tottori 683-8504, Japan, Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe, Kyoto 610-0321, Japan, and Cardiovascular Division, British Heart Foundation Centre of Research Excellence, School of Medicine, King's College London, London SE1 9NH, United Kingdom.

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http://dx.doi.org/10.1523/JNEUROSCI.2954-12.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6705174PMC
September 2013