Publications by authors named "Takeshi Okanoue"

100Publications

Effect of Pemafibrate on fatty acid levels and liver enzyme in NAFLD patients with Dyslipidemia: a single-arm, pilot study.

Hepatol Res 2020 Sep 14. Epub 2020 Sep 14.

Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

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http://dx.doi.org/10.1111/hepr.13571DOI Listing
September 2020

Epidemiology: Pathogenesis, and Diagnostic Strategy of Diabetic Liver Disease in Japan.

Int J Mol Sci 2020 Jun 18;21(12). Epub 2020 Jun 18.

Center of Gastroenterology and Hepatology, Saiseikai Suita Hospital, Osaka 564-0013, Japan.

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http://dx.doi.org/10.3390/ijms21124337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352222PMC
June 2020

Identification of Patients with Advanced Fibrosis Due to Nonalcoholic Fatty Liver Disease: Considerations for Best Practice.

J Gastrointestin Liver Dis 2020 Jun 3;29(2):235-245. Epub 2020 Jun 3.

UCM Digestive Diseases, Virgen del Rocío University Hospital, University of Seville, Seville, Spain.

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http://dx.doi.org/10.15403/jgld-775DOI Listing
June 2020

Attenuated effect of PNPLA3 on hepatic fibrosis by HSD17B13 in Japanese patients with non-alcoholic fatty liver disease.

Liver Int 2020 Jul 12;40(7):1686-1692. Epub 2020 May 12.

Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

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http://dx.doi.org/10.1111/liv.14495DOI Listing
July 2020

Current and new pharmacotherapy options for non-alcoholic steatohepatitis.

Expert Opin Pharmacother 2020 Jun 1;21(8):953-967. Epub 2020 Apr 1.

Department of Gastroenterology and Hepatology, Yokohama City University , Yokohama, Japan.

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http://dx.doi.org/10.1080/14656566.2020.1744564DOI Listing
June 2020

Phase 3 drug pipelines in the treatment of non-alcoholic steatohepatitis.

Hepatol Res 2019 Nov 25;49(11):1256-1262. Epub 2019 Oct 25.

Department of Gastroenterology and Hepatology, Yokohama City University, Yokohama, Japan.

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http://dx.doi.org/10.1111/hepr.13425DOI Listing
November 2019

Is the grade of ballooned hepatocytes a significant risk factor for rapid progression of hepatic fibrosis in patients with NAFLD?

J Gastroenterol 2019 05 26;54(5):474-475. Epub 2019 Mar 26.

Hepatology Center, Saiseikai Suita Hospital, Suita, Japan.

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http://link.springer.com/10.1007/s00535-019-01573-x
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http://dx.doi.org/10.1007/s00535-019-01573-xDOI Listing
May 2019

A simple scoring system using type IV collagen 7S and aspartate aminotransferase for diagnosing nonalcoholic steatohepatitis and related fibrosis.

J Gastroenterol 2018 01 6;53(1):129-139. Epub 2017 Jun 6.

Genomic Science Laboratories, Sumitomo Dainippon Pharma Co., Ltd., 3-1-98 Kasugadenaka, Konohana-ku, Osaka, 554-0022, Japan.

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http://dx.doi.org/10.1007/s00535-017-1355-9DOI Listing
January 2018

Pathological findings of nonalcoholic steatohepatitis and nonalcoholic fatty liver disease.

Pathol Int 2017 Jan 20;67(1):1-7. Epub 2016 Dec 20.

Working Group and Association of Pathologists for Guidebook of NASH and NAFLD, 2015: The Japan Society of Hepatology.

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http://dx.doi.org/10.1111/pin.12485DOI Listing
January 2017

Assessment of transient elastography in Japanese patients with non-alcoholic fatty liver disease.

Hepatol Res 2017 Aug 25;47(9):882-889. Epub 2016 Nov 25.

Department of Gastroenterology and Hepatology, Saiseikai Suita Hospital, Suita, Japan.

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http://dx.doi.org/10.1111/hepr.12829DOI Listing
August 2017

[Present State of Non-B Non-C Liver Disease-and Its Monitoring.]

Rinsho Byori 2016 May;64(4):472-479

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May 2016

Identification of novel noninvasive markers for diagnosing nonalcoholic steatohepatitis and related fibrosis by data mining.

Hepatology 2016 Feb 14;63(2):462-73. Epub 2015 Dec 14.

Genomic Science Laboratories, Sumitomo Dainippon Pharma Co., Ltd., Osaka, Japan.

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http://dx.doi.org/10.1002/hep.28226DOI Listing
February 2016

Effect of PNPLA3 rs738409 variant (I148 M) on hepatic steatosis, necroinflammation, and fibrosis in Japanese patients with chronic hepatitis C.

J Gastroenterol 2015 Aug 26;50(8):887-93. Epub 2014 Nov 26.

Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

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http://dx.doi.org/10.1007/s00535-014-1018-zDOI Listing
August 2015

Simple scoring system for predicting cirrhosis in nonalcoholic fatty liver disease.

World J Gastroenterol 2014 Aug;20(29):10108-14

Takaomi Kessoku, Yuji Ogawa, Masato Yoneda, Kento Imajo, Atsushi Nakajima, Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.

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http://dx.doi.org/10.3748/wjg.v20.i29.10108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123339PMC
August 2014

Influence of lifestyle-related diseases and age on the development and progression of non-alcoholic fatty liver disease.

Hepatol Res 2015 May 13;45(5):548-59. Epub 2014 Aug 13.

Department of Gastroenterology and Hepatology, Saiseikai Suita Hospital, Osaka, Japan.

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http://dx.doi.org/10.1111/hepr.12384DOI Listing
May 2015

Clinical characteristics, treatment, and prognosis of non-B, non-C hepatocellular carcinoma: a large retrospective multicenter cohort study.

J Gastroenterol 2015 Mar 15;50(3):350-60. Epub 2014 Jun 15.

Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan,

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http://dx.doi.org/10.1007/s00535-014-0973-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352653PMC
March 2015

Efficacy and safety of sorafenib in very elderly patients aged 80 years and older with advanced hepatocellular carcinoma.

Hepatol Res 2014 Dec 2;44(13):1329-38. Epub 2014 Apr 2.

Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan; Department of Molecular Gastroenterology and Hepatology, North Medical Center Kyoto Prefectural University of Medicine, Yosano, Japan.

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http://dx.doi.org/10.1111/hepr.12308DOI Listing
December 2014

Interleukin 28B polymorphism predicts interferon plus ribavirin treatment outcome in patients with hepatitis C virus-related liver cirrhosis: A multicenter retrospective study in Japan.

Hepatol Res 2014 Sep 9;44(9):983-92. Epub 2014 Jan 9.

Department of Gastroenterology and Medicine, Faculty of Medicine, Fukuoka University, Fukuoka, Japan; Division of Advanced Clinical Research for Viral Hepatitis and Liver Cancer, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.

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http://doi.wiley.com/10.1111/hepr.12280
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http://dx.doi.org/10.1111/hepr.12280DOI Listing
September 2014

Pathogenic Role of Iron Deposition in Reticuloendothelial Cells during the Development of Chronic Hepatitis C.

Int J Hepatol 2013 4;2013:686420. Epub 2013 Apr 4.

Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi Hirokouji, Kamigyo-ku, Kyoto 602-8566, Osaka 564-0013, Japan.

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http://downloads.hindawi.com/journals/ijh/2013/686420.pdf
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http://www.hindawi.com/journals/ijh/2013/686420/
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http://dx.doi.org/10.1155/2013/686420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638689PMC
May 2013

Difference in serum complement component C4a levels between hepatitis C virus carriers with persistently normal alanine aminotransferase levels or chronic hepatitis C.

Mol Med Rep 2012 Aug 21;6(2):259-64. Epub 2012 May 21.

Digestive and Lifestyle Diseases, Department of Human and Environmental Sciences, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

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http://dx.doi.org/10.3892/mmr.2012.924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493081PMC
August 2012

Treatment extension may benefit female genotype 1 chronic hepatitis C patients with complete early virological response to peginterferon-alpha-2b and ribavirin combination therapy.

Hepatol Res 2012 Oct 1;42(10):966-73. Epub 2012 May 1.

Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science Department of Internal Medicine, Aiseikai Yamashina Hospital, Kyoto Hepatology Center, Saiseikai Suita Hospital Department of Gastroenterology, Matsushita Memorial Hospital, Osaka, Japan.

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http://dx.doi.org/10.1111/j.1872-034X.2012.01016.xDOI Listing
October 2012

Clinical and pathological progression of non-alcoholic steatohepatitis to hepatocellular carcinoma.

Hepatol Res 2012 Aug 4;42(8):767-73. Epub 2012 Apr 4.

Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kagoshima, Japan.

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http://dx.doi.org/10.1111/j.1872-034X.2012.00986.xDOI Listing
August 2012

Coordinated ciliary beating requires Odf2-mediated polarization of basal bodies via basal feet.

Cell 2012 Jan;148(1-2):189-200

Laboratory of Biological Science, Graduate School of Frontier Biosciences and Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan.

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http://dx.doi.org/10.1016/j.cell.2011.10.052DOI Listing
January 2012

[The past, present and future treatment for chronic hepatitis B].

Nihon Rinsho 2011 May;69 Suppl 4:469-74

Center of Gastroenterology and Hepatology, Saiseikai Suita Hospital.

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May 2011

[Treatment for chronic hepatitis with normal serum ALT].

Nihon Rinsho 2011 May;69 Suppl 4:156-60

Center of Hepatology, Saiseikai Suita Hospital.

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May 2011

17β-Estradiol attenuates saturated fatty acid diet-induced liver injury in ovariectomized mice by up-regulating hepatic senescence marker protein-30.

Biochem Biophys Res Commun 2011 Nov 19;415(2):252-7. Epub 2011 Oct 19.

Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2011.10.025DOI Listing
November 2011

Hepatic steatosis in chronic hepatitis C patients infected with genotype 2 is associated with insulin resistance, hepatic fibrosis and affects cumulative positivity of serum hepatitis C virus RNA in peginterferon and ribavirin combination therapy.

Hepatol Res 2011 Dec 26;41(12):1145-52. Epub 2011 Sep 26.

Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto Department of Gastroenterology, Matsushita Memorial Hospital Hepatology Center, Saiseikai Suita Hospital, Osaka Department of Gastroenterology and Hepatology Nara City Hospital, Nara, Japan.

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http://dx.doi.org/10.1111/j.1872-034X.2011.00886.xDOI Listing
December 2011

Telaprevir with peginterferon and ribavirin for treatment-naive patients chronically infected with HCV of genotype 1 in Japan.

J Hepatol 2012 Jan 7;56(1):78-84. Epub 2011 Aug 7.

Department of Hepatology, Toranomon Hospital, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.jhep.2011.07.016DOI Listing
January 2012

High expression of p300 in HCC predicts shortened overall survival in association with enhanced epithelial mesenchymal transition of HCC cells.

Cancer Lett 2011 Nov 1;310(2):140-7. Epub 2011 Jul 1.

Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

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http://dx.doi.org/10.1016/j.canlet.2011.06.030DOI Listing
November 2011

[Recent progress in the research of NASH/NAFLD in Japan].

Authors:
Takeshi Okanoue

Nihon Shokakibyo Gakkai Zasshi 2011 Jul;108(7):1161-9

Saiseikai Suita Hospital.

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July 2011

[Progress and perspectives in treatment of chronic hepatitis B].

Nihon Rinsho 2011 Apr;69(4):737-41

Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine.

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April 2011

Blockade of IL-6 signaling exacerbates liver injury and suppresses antiapoptotic gene expression in methionine choline-deficient diet-fed db/db mice.

Lab Invest 2011 Apr 14;91(4):609-18. Epub 2011 Feb 14.

Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

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http://dx.doi.org/10.1038/labinvest.2011.2DOI Listing
April 2011

Characteristics of patients with nonalcoholic steatohepatitis who develop hepatocellular carcinoma.

Clin Gastroenterol Hepatol 2011 May 12;9(5):428-33; quiz e50. Epub 2011 Feb 12.

Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

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http://dx.doi.org/10.1016/j.cgh.2011.01.023DOI Listing
May 2011

Simple formula to predict response to peginterferon alpha2b and ribavirin combination therapy in genotype 1 chronic hepatitis C patients with high viral loads.

Hepatol Res 2011 Feb;41(2):126-32

Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto Hepatology Center, Saiseikai Suita Hospital Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Osaka Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Ehime, Japan.

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http://dx.doi.org/10.1111/j.1872-034X.2010.00750.xDOI Listing
February 2011

Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis in Japan.

J Gastroenterol Hepatol 2011 Jan;26 Suppl 1:153-62

Center of Gastroenterology and Hepatology, Saiseikai Suita Hospital, Osaka, Japan.

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http://doi.wiley.com/10.1111/j.1440-1746.2010.06547.x
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http://dx.doi.org/10.1111/j.1440-1746.2010.06547.xDOI Listing
January 2011

Accumulation of refractory factors for pegylated interferon plus ribavirin therapy in older female patients with chronic hepatitis C.

Hepatol Res 2010 Dec 7;40(12):1155-67. Epub 2010 Oct 7.

Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.

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http://dx.doi.org/10.1111/j.1872-034X.2010.00726.xDOI Listing
December 2010

SOX2 identified as a target gene for the amplification at 3q26 that is frequently detected in esophageal squamous cell carcinoma.

Cancer Genet Cytogenet 2010 Oct;202(2):82-93

Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, Japan.

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http://dx.doi.org/10.1016/j.cancergencyto.2010.01.023DOI Listing
October 2010

Nonalcoholic steatohepatitis and increased risk of chronic kidney disease.

Metabolism 2011 May 3;60(5):735-9. Epub 2010 Sep 3.

Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto 602-8566, Japan.

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http://dx.doi.org/10.1016/j.metabol.2010.07.022DOI Listing
May 2011

Blockade of interleukin-6 signaling enhances hepatic steatosis but improves liver injury in methionine choline-deficient diet-fed mice.

Lab Invest 2010 Aug 5;90(8):1169-78. Epub 2010 Apr 5.

Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

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http://dx.doi.org/10.1038/labinvest.2010.75DOI Listing
August 2010

PEG10 is a probable target for the amplification at 7q21 detected in hepatocellular carcinoma.

Cancer Genet Cytogenet 2010 Apr;198(2):118-25

Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto 602-8566, Japan.

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http://dx.doi.org/10.1016/j.cancergencyto.2010.01.004DOI Listing
April 2010

Interferon and nucleoside analog combination therapy for hepatitis B.

Clin J Gastroenterol 2010 Apr 23;3(2):69-72. Epub 2010 Feb 23.

Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji, Kawaramachi, Kamigyo-ku, Kyoto, 602-8566, Japan.

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http://dx.doi.org/10.1007/s12328-010-0135-3DOI Listing
April 2010

Identification of a novel biomarker for oxidative stress induced by hydrogen peroxide in primary human hepatocytes using the 2-nitrobenzenesulfenyl chloride isotope labeling method.

Hepatol Res 2010 Apr 7;40(4):438-45. Epub 2010 Mar 7.

Department of Digestive and Lifestyle-related Disease, Health Research, Human and Environmental Sciences, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima.

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http://doi.wiley.com/10.1111/j.1872-034X.2009.00615.x
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http://dx.doi.org/10.1111/j.1872-034X.2009.00615.xDOI Listing
April 2010