Takeshi Okanoue

Takeshi Okanoue

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Takeshi Okanoue

Publications by authors named "Takeshi Okanoue"

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Phase 3 drug pipelines in the treatment of NASH.

Hepatol Res 2019 Sep 8. Epub 2019 Sep 8.

Department of Gastroenterology and Hepatology, Yokohama City University.

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http://dx.doi.org/10.1111/hepr.13425DOI Listing
September 2019

Is the grade of ballooned hepatocytes a significant risk factor for rapid progression of hepatic fibrosis in patients with NAFLD?

J Gastroenterol 2019 May 26;54(5):474-475. Epub 2019 Mar 26.

Hepatology Center, Saiseikai Suita Hospital, Suita, Japan.

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http://link.springer.com/10.1007/s00535-019-01573-x
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http://dx.doi.org/10.1007/s00535-019-01573-xDOI Listing
May 2019

A simple scoring system using type IV collagen 7S and aspartate aminotransferase for diagnosing nonalcoholic steatohepatitis and related fibrosis.

J Gastroenterol 2018 01 6;53(1):129-139. Epub 2017 Jun 6.

Genomic Science Laboratories, Sumitomo Dainippon Pharma Co., Ltd., 3-1-98 Kasugadenaka, Konohana-ku, Osaka, 554-0022, Japan.

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http://dx.doi.org/10.1007/s00535-017-1355-9DOI Listing
January 2018

Assessment of transient elastography in Japanese patients with non-alcoholic fatty liver disease.

Hepatol Res 2017 Aug 25;47(9):882-889. Epub 2016 Nov 25.

Department of Gastroenterology and Hepatology, Saiseikai Suita Hospital, Suita, Japan.

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http://dx.doi.org/10.1111/hepr.12829DOI Listing
August 2017

Pathological findings of nonalcoholic steatohepatitis and nonalcoholic fatty liver disease.

Pathol Int 2017 Jan 20;67(1):1-7. Epub 2016 Dec 20.

Working Group and Association of Pathologists for Guidebook of NASH and NAFLD, 2015: The Japan Society of Hepatology.

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http://dx.doi.org/10.1111/pin.12485DOI Listing
January 2017

[Present State of Non-B Non-C Liver Disease-and Its Monitoring.]

Rinsho Byori 2016 May;64(4):472-479

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May 2016

Identification of novel noninvasive markers for diagnosing nonalcoholic steatohepatitis and related fibrosis by data mining.

Hepatology 2016 Feb 14;63(2):462-73. Epub 2015 Dec 14.

Genomic Science Laboratories, Sumitomo Dainippon Pharma Co., Ltd., Osaka, Japan.

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http://dx.doi.org/10.1002/hep.28226DOI Listing
February 2016

Effect of PNPLA3 rs738409 variant (I148 M) on hepatic steatosis, necroinflammation, and fibrosis in Japanese patients with chronic hepatitis C.

J Gastroenterol 2015 Aug 26;50(8):887-93. Epub 2014 Nov 26.

Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

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http://dx.doi.org/10.1007/s00535-014-1018-zDOI Listing
August 2015

Influence of lifestyle-related diseases and age on the development and progression of non-alcoholic fatty liver disease.

Hepatol Res 2015 May 13;45(5):548-59. Epub 2014 Aug 13.

Department of Gastroenterology and Hepatology, Saiseikai Suita Hospital, Osaka, Japan.

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http://dx.doi.org/10.1111/hepr.12384DOI Listing
May 2015

Clinical characteristics, treatment, and prognosis of non-B, non-C hepatocellular carcinoma: a large retrospective multicenter cohort study.

J Gastroenterol 2015 Mar 15;50(3):350-60. Epub 2014 Jun 15.

Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan,

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http://dx.doi.org/10.1007/s00535-014-0973-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352653PMC
March 2015

Efficacy and safety of sorafenib in very elderly patients aged 80 years and older with advanced hepatocellular carcinoma.

Hepatol Res 2014 Dec 2;44(13):1329-38. Epub 2014 Apr 2.

Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan; Department of Molecular Gastroenterology and Hepatology, North Medical Center Kyoto Prefectural University of Medicine, Yosano, Japan.

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http://dx.doi.org/10.1111/hepr.12308DOI Listing
December 2014

Interleukin 28B polymorphism predicts interferon plus ribavirin treatment outcome in patients with hepatitis C virus-related liver cirrhosis: A multicenter retrospective study in Japan.

Hepatol Res 2014 Sep 9;44(9):983-92. Epub 2014 Jan 9.

Department of Gastroenterology and Medicine, Faculty of Medicine, Fukuoka University, Fukuoka, Japan; Division of Advanced Clinical Research for Viral Hepatitis and Liver Cancer, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.

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http://doi.wiley.com/10.1111/hepr.12280
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http://dx.doi.org/10.1111/hepr.12280DOI Listing
September 2014

Simple scoring system for predicting cirrhosis in nonalcoholic fatty liver disease.

World J Gastroenterol 2014 Aug;20(29):10108-14

Takaomi Kessoku, Yuji Ogawa, Masato Yoneda, Kento Imajo, Atsushi Nakajima, Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.

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http://dx.doi.org/10.3748/wjg.v20.i29.10108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123339PMC
August 2014

Pathogenic Role of Iron Deposition in Reticuloendothelial Cells during the Development of Chronic Hepatitis C.

Int J Hepatol 2013 4;2013:686420. Epub 2013 Apr 4.

Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi Hirokouji, Kamigyo-ku, Kyoto 602-8566, Osaka 564-0013, Japan.

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http://downloads.hindawi.com/journals/ijh/2013/686420.pdf
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http://www.hindawi.com/journals/ijh/2013/686420/
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http://dx.doi.org/10.1155/2013/686420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638689PMC
May 2013

Treatment extension may benefit female genotype 1 chronic hepatitis C patients with complete early virological response to peginterferon-alpha-2b and ribavirin combination therapy.

Hepatol Res 2012 Oct 1;42(10):966-73. Epub 2012 May 1.

Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science Department of Internal Medicine, Aiseikai Yamashina Hospital, Kyoto Hepatology Center, Saiseikai Suita Hospital Department of Gastroenterology, Matsushita Memorial Hospital, Osaka, Japan.

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http://dx.doi.org/10.1111/j.1872-034X.2012.01016.xDOI Listing
October 2012

Clinical and pathological progression of non-alcoholic steatohepatitis to hepatocellular carcinoma.

Hepatol Res 2012 Aug 4;42(8):767-73. Epub 2012 Apr 4.

Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kagoshima, Japan.

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http://dx.doi.org/10.1111/j.1872-034X.2012.00986.xDOI Listing
August 2012

Difference in serum complement component C4a levels between hepatitis C virus carriers with persistently normal alanine aminotransferase levels or chronic hepatitis C.

Mol Med Rep 2012 Aug 21;6(2):259-64. Epub 2012 May 21.

Digestive and Lifestyle Diseases, Department of Human and Environmental Sciences, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

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http://dx.doi.org/10.3892/mmr.2012.924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493081PMC
August 2012

Telaprevir with peginterferon and ribavirin for treatment-naive patients chronically infected with HCV of genotype 1 in Japan.

J Hepatol 2012 Jan 7;56(1):78-84. Epub 2011 Aug 7.

Department of Hepatology, Toranomon Hospital, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.jhep.2011.07.016DOI Listing
January 2012

Coordinated ciliary beating requires Odf2-mediated polarization of basal bodies via basal feet.

Cell 2012 Jan;148(1-2):189-200

Laboratory of Biological Science, Graduate School of Frontier Biosciences and Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan.

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http://dx.doi.org/10.1016/j.cell.2011.10.052DOI Listing
January 2012

Hepatic steatosis in chronic hepatitis C patients infected with genotype 2 is associated with insulin resistance, hepatic fibrosis and affects cumulative positivity of serum hepatitis C virus RNA in peginterferon and ribavirin combination therapy.

Hepatol Res 2011 Dec 26;41(12):1145-52. Epub 2011 Sep 26.

Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto Department of Gastroenterology, Matsushita Memorial Hospital Hepatology Center, Saiseikai Suita Hospital, Osaka Department of Gastroenterology and Hepatology Nara City Hospital, Nara, Japan.

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http://dx.doi.org/10.1111/j.1872-034X.2011.00886.xDOI Listing
December 2011

Obstructive jaundice with fever and eosinophilia.

BMJ Case Rep 2009 16;2009:bcr2006107912. Epub 2009 Feb 16.

Department of Gastroenterology and Hepatology, Nantan General Hospital, Kyoto, Japan.

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http://dx.doi.org/10.1136/bcr.2006.107912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3106058PMC
November 2011

High expression of p300 in HCC predicts shortened overall survival in association with enhanced epithelial mesenchymal transition of HCC cells.

Cancer Lett 2011 Nov 1;310(2):140-7. Epub 2011 Jul 1.

Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

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http://dx.doi.org/10.1016/j.canlet.2011.06.030DOI Listing
November 2011

17β-Estradiol attenuates saturated fatty acid diet-induced liver injury in ovariectomized mice by up-regulating hepatic senescence marker protein-30.

Biochem Biophys Res Commun 2011 Nov 19;415(2):252-7. Epub 2011 Oct 19.

Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2011.10.025DOI Listing
November 2011

[Recent progress in the research of NASH/NAFLD in Japan].

Authors:
Takeshi Okanoue

Nihon Shokakibyo Gakkai Zasshi 2011 Jul;108(7):1161-9

Saiseikai Suita Hospital.

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July 2011

Nonalcoholic steatohepatitis and increased risk of chronic kidney disease.

Metabolism 2011 May 3;60(5):735-9. Epub 2010 Sep 3.

Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto 602-8566, Japan.

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http://dx.doi.org/10.1016/j.metabol.2010.07.022DOI Listing
May 2011

Characteristics of patients with nonalcoholic steatohepatitis who develop hepatocellular carcinoma.

Clin Gastroenterol Hepatol 2011 May 12;9(5):428-33; quiz e50. Epub 2011 Feb 12.

Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

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http://dx.doi.org/10.1016/j.cgh.2011.01.023DOI Listing
May 2011

[Treatment for chronic hepatitis with normal serum ALT].

Nihon Rinsho 2011 May;69 Suppl 4:156-60

Center of Hepatology, Saiseikai Suita Hospital.

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May 2011

[The past, present and future treatment for chronic hepatitis B].

Nihon Rinsho 2011 May;69 Suppl 4:469-74

Center of Gastroenterology and Hepatology, Saiseikai Suita Hospital.

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May 2011

Blockade of IL-6 signaling exacerbates liver injury and suppresses antiapoptotic gene expression in methionine choline-deficient diet-fed db/db mice.

Lab Invest 2011 Apr 14;91(4):609-18. Epub 2011 Feb 14.

Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

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http://dx.doi.org/10.1038/labinvest.2011.2DOI Listing
April 2011

[Progress and perspectives in treatment of chronic hepatitis B].

Nihon Rinsho 2011 Apr;69(4):737-41

Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine.

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April 2011

Simple formula to predict response to peginterferon alpha2b and ribavirin combination therapy in genotype 1 chronic hepatitis C patients with high viral loads.

Hepatol Res 2011 Feb;41(2):126-32

Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto Hepatology Center, Saiseikai Suita Hospital Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Osaka Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Ehime, Japan.

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http://dx.doi.org/10.1111/j.1872-034X.2010.00750.xDOI Listing
February 2011

Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis in Japan.

J Gastroenterol Hepatol 2011 Jan;26 Suppl 1:153-62

Center of Gastroenterology and Hepatology, Saiseikai Suita Hospital, Osaka, Japan.

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http://doi.wiley.com/10.1111/j.1440-1746.2010.06547.x
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http://dx.doi.org/10.1111/j.1440-1746.2010.06547.xDOI Listing
January 2011

Accumulation of refractory factors for pegylated interferon plus ribavirin therapy in older female patients with chronic hepatitis C.

Hepatol Res 2010 Dec 7;40(12):1155-67. Epub 2010 Oct 7.

Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.

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http://dx.doi.org/10.1111/j.1872-034X.2010.00726.xDOI Listing
December 2010

SOX2 identified as a target gene for the amplification at 3q26 that is frequently detected in esophageal squamous cell carcinoma.

Cancer Genet Cytogenet 2010 Oct;202(2):82-93

Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, Japan.

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http://dx.doi.org/10.1016/j.cancergencyto.2010.01.023DOI Listing
October 2010

Blockade of interleukin-6 signaling enhances hepatic steatosis but improves liver injury in methionine choline-deficient diet-fed mice.

Lab Invest 2010 Aug 5;90(8):1169-78. Epub 2010 Apr 5.

Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

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http://dx.doi.org/10.1038/labinvest.2010.75DOI Listing
August 2010

Steatosis and hepatic expression of genes regulating lipid metabolism in Japanese patients infected with hepatitis C virus.

J Gastroenterol 2010 30;45(1):95-104. Epub 2009 Sep 30.

Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto 602-8566, Japan.

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http://dx.doi.org/10.1007/s00535-009-0133-8DOI Listing
April 2010

Identification of a novel biomarker for oxidative stress induced by hydrogen peroxide in primary human hepatocytes using the 2-nitrobenzenesulfenyl chloride isotope labeling method.

Hepatol Res 2010 Apr 7;40(4):438-45. Epub 2010 Mar 7.

Department of Digestive and Lifestyle-related Disease, Health Research, Human and Environmental Sciences, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima.

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http://doi.wiley.com/10.1111/j.1872-034X.2009.00615.x
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http://dx.doi.org/10.1111/j.1872-034X.2009.00615.xDOI Listing
April 2010

Interferon and nucleoside analog combination therapy for hepatitis B.

Clin J Gastroenterol 2010 Apr 23;3(2):69-72. Epub 2010 Feb 23.

Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji, Kawaramachi, Kamigyo-ku, Kyoto, 602-8566, Japan.

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http://dx.doi.org/10.1007/s12328-010-0135-3DOI Listing
April 2010

PEG10 is a probable target for the amplification at 7q21 detected in hepatocellular carcinoma.

Cancer Genet Cytogenet 2010 Apr;198(2):118-25

Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto 602-8566, Japan.

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http://dx.doi.org/10.1016/j.cancergencyto.2010.01.004DOI Listing
April 2010

Infrequent amplification of JUN in hepatocellular carcinoma.

Anticancer Res 2009 Dec;29(12):4989-94

Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto 602-8566, Japan.

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December 2009

Involvement of IQGAP3, a regulator of Ras/ERK-related cascade, in hepatocyte proliferation in mouse liver regeneration and development.

J Cell Physiol 2009 Sep;220(3):621-31

Laboratory of Biological Science, Graduate School of Frontier Biosciences and Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan.

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http://doi.wiley.com/10.1002/jcp.21798
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http://dx.doi.org/10.1002/jcp.21798DOI Listing
September 2009

Oxidative stress may enhance the malignant potential of human hepatocellular carcinoma by telomerase activation.

Liver Int 2009 Jul 24;29(6):846-56. Epub 2008 Dec 24.

Kyoto Prefectural University of Medicine Graduate School of Medical Science, Molecular Gastroenterology and Hepatology, Kyoto, Japan.

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http://dx.doi.org/10.1111/j.1478-3231.2008.01963.xDOI Listing
July 2009

Risk factors and clinical course of portal and/or splenic vein thrombosis after partial splenic embolization.

Acta Radiol 2009 Jul;50(6):617-23

Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajiicho, Kawaramachi Hirokoji, Kamigyo-ku, Kyoto, Japan.

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http://dx.doi.org/10.1080/02841850902922779DOI Listing
July 2009

Analysis of hepatic genes involved in the metabolism of fatty acids and iron in nonalcoholic fatty liver disease.

Hepatol Res 2009 Apr 25;39(4):366-73. Epub 2008 Nov 25.

Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

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http://dx.doi.org/10.1111/j.1872-034X.2008.00464.xDOI Listing
April 2009

Correlations between p53 gene mutations and histologic characteristics of pancreatic ductal carcinoma.

Pancreas 2009 Mar;38(2):e60-7

Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

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http://dx.doi.org/10.1097/mpa.0b013e318197a3f5DOI Listing
March 2009

Role of hepatic iron in non-alcoholic steatohepatitis.

Hepatol Res 2009 Mar;39(3):213-22

Center for Digestive and Liver Diseases, Nara City Hospital, Nara, Japan.

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http://dx.doi.org/10.1111/j.1872-034X.2008.00442.xDOI Listing
March 2009

[Management of hepatitis C and fatty liver: a consciousness survey among gastroenterologists and general internists].

Nihon Shokakibyo Gakkai Zasshi 2008 Dec;105(12):1737-48

Division of Gastroenterology, Saiseikai Suita Hospital.

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December 2008