Takeshi Kuwata

Takeshi Kuwata

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Takeshi Kuwata

Publications by authors named "Takeshi Kuwata"

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Extra-perigastric Extranodal Metastasis is a Significant Prognostic Factor in Node-Positive Gastric Cancer.

World J Surg 2019 10;43(10):2499-2505

Department of Pathology and Clinical Laboratories, National Cancer Center Hospital East, Kashiwa, Japan.

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http://dx.doi.org/10.1007/s00268-019-05076-xDOI Listing
October 2019

Proportion of goblet cell is associated with malignant potential in invasive mucinous adenocarcinoma of the lung.

Pathol Int 2019 Sep;69(9):526-535

Division of Pathology, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center Hospital East, Kashiwa, Japan.

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http://dx.doi.org/10.1111/pin.12853DOI Listing
September 2019

HER2 heterogeneity is a poor prognosticator for HER2-positive gastric cancer.

World J Clin Cases 2019 Aug;7(15):1964-1977

Department of Gastric Surgery, National Cancer Center Hospital East, Kashiwa 277-8577, Japan.

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http://dx.doi.org/10.12998/wjcc.v7.i15.1964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695545PMC
August 2019

Predictive factors for hyperprogressive disease during nivolumab as anti-PD1 treatment in patients with advanced gastric cancer.

Gastric Cancer 2019 07 9;22(4):793-802. Epub 2019 Jan 9.

Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

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http://dx.doi.org/10.1007/s10120-018-00922-8DOI Listing
July 2019

Growth patterns of small peripheral squamous cell carcinoma of the lung and their impacts on pathological and biological characteristics of tumor cells.

J Cancer Res Clin Oncol 2019 Jul 21;145(7):1773-1783. Epub 2019 May 21.

Division of Pathology, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

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http://dx.doi.org/10.1007/s00432-019-02937-9DOI Listing
July 2019

Depressed gastric-type adenoma in nonatrophic gastric mucosa without Helicobacter pylori infection.

Endoscopy 2019 Jun 25;51(6):E138-E140. Epub 2019 Mar 25.

Department of Gastroenterology and Endoscopy, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.

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http://dx.doi.org/10.1055/a-0866-9051DOI Listing
June 2019

Clinicopathological characteristics associated with necrosis in pulmonary metastases from colorectal cancer.

Virchows Arch 2019 May 14;474(5):569-575. Epub 2019 Feb 14.

Division of Pathology, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center 6-5-1, Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

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http://dx.doi.org/10.1007/s00428-019-02535-7DOI Listing
May 2019

Human epidermal growth factor receptor 2-, epidermal growth factor receptor-, and mesenchymal epithelial transition factor-positive sites of gastric cancer using surgical samples.

Gastric Cancer 2019 03 27;22(2):335-343. Epub 2018 Jun 27.

Department of Gastroenterology and Endoscopy, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

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http://dx.doi.org/10.1007/s10120-018-0853-7DOI Listing
March 2019

Link between tumor-promoting fibrous microenvironment and an immunosuppressive microenvironment in stage I lung adenocarcinoma.

Lung Cancer 2018 12 28;126:64-71. Epub 2018 Oct 28.

Division of Pathology, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, 6-5-1, Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.lungcan.2018.10.021DOI Listing
December 2018

Characterization of low active ghrelin ratio in patients with advanced pancreatic cancer.

Support Care Cancer 2018 Nov 18;26(11):3811-3817. Epub 2018 May 18.

Pathology Division, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

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http://dx.doi.org/10.1007/s00520-018-4248-4DOI Listing
November 2018

Establishment of a novel cell line from a rare human duodenal poorly differentiated neuroendocrine carcinoma.

Oncotarget 2018 Nov 23;9(92):36503-36514. Epub 2018 Nov 23.

Division of Pathology, Department of Pathology, Kobe University Graduate School of Medicine, Kobe, Japan.

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http://dx.doi.org/10.18632/oncotarget.26367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284856PMC
November 2018

Differences of tumor microenvironment between stage I lepidic-positive and lepidic-negative lung adenocarcinomas.

J Thorac Cardiovasc Surg 2018 10 4;156(4):1679-1688.e2. Epub 2018 Jun 4.

Division of Pathology, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwa, Chiba, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jtcvs.2018.05.053DOI Listing
October 2018

Targeting VEGFR2 with Ramucirumab strongly impacts effector/ activated regulatory T cells and CD8 T cells in the tumor microenvironment.

J Immunother Cancer 2018 10 11;6(1):106. Epub 2018 Oct 11.

Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

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https://jitc.biomedcentral.com/articles/10.1186/s40425-018-0
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http://dx.doi.org/10.1186/s40425-018-0403-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186121PMC
October 2018

Clinicopathological features and endoscopic findings of HER2-positive gastric cancer.

Surg Endosc 2018 09 2;32(9):3964-3971. Epub 2018 Mar 2.

Department of Gastroenterology and Endoscopy, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

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http://dx.doi.org/10.1007/s00464-018-6138-8DOI Listing
September 2018

Case of pyloric gland adenoma accompanied by a component of foveolar epithelial-type adenoma within the lesion.

Dig Endosc 2018 09 29;30(5):673. Epub 2018 May 29.

Division of Pathology, National Cancer Center Hospital East, Kashiwa, Japan.

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http://dx.doi.org/10.1111/den.13180DOI Listing
September 2018

Immunosuppressive tumor microenvironment of usual interstitial pneumonia-associated squamous cell carcinoma of the lung.

J Cancer Res Clin Oncol 2018 May 12;144(5):835-844. Epub 2018 Feb 12.

Division of Pathology, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, 6-5-1, Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

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http://link.springer.com/10.1007/s00432-018-2602-z
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http://dx.doi.org/10.1007/s00432-018-2602-zDOI Listing
May 2018

Podoplanin-positive cancer-associated fibroblast recruitment within cancer stroma is associated with a higher number of single nucleotide variants in cancer cells in lung adenocarcinoma.

J Cancer Res Clin Oncol 2018 May 6;144(5):893-900. Epub 2018 Mar 6.

Division of Pathology, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

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http://dx.doi.org/10.1007/s00432-018-2619-3DOI Listing
May 2018

Neural Invasion Spreads Macrophage-Related Allodynia via Neural Root in Pancreatic Cancer.

Anesth Analg 2018 05;126(5):1729-1738

From the Division of Biomarker Discovery, Exploratory Oncology Research and Clinical Trial Center.

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http://dx.doi.org/10.1213/ANE.0000000000002803DOI Listing
May 2018

A case of a protruded lesion formed by a poorly differentiated intramucosal adenocarcinoma of the stomach: an immunohistochemical analysis.

Clin J Gastroenterol 2018 Apr 11;11(2):127-132. Epub 2017 Dec 11.

Department of Gastroenterology and Endoscopy, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

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http://dx.doi.org/10.1007/s12328-017-0804-6DOI Listing
April 2018

The ratio of cancer cells to stroma within the invasive area is a histologic prognostic parameter of lung adenocarcinoma.

Lung Cancer 2018 04 31;118:30-35. Epub 2018 Jan 31.

Division of Pathology, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwa, Chiba, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.lungcan.2018.01.023DOI Listing
April 2018

Abundant tumor promoting stromal cells in lung adenocarcinoma with hypoxic regions.

Lung Cancer 2018 01 20;115:56-63. Epub 2017 Nov 20.

Division of Pathology, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, 6-5-1, Kashiwanoha, Kashiwa-City, Chiba 277-8577, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.lungcan.2017.11.013DOI Listing
January 2018

Phase 1 study of sulfasalazine and cisplatin for patients with CD44v-positive gastric cancer refractory to cisplatin (EPOC1407).

Gastric Cancer 2017 Nov 2;20(6):1004-1009. Epub 2017 May 2.

Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

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http://dx.doi.org/10.1007/s10120-017-0720-yDOI Listing
November 2017

Immunohistochemical and genetic characteristics of lung cancer mimicking organizing pneumonia.

Lung Cancer 2017 11 5;113:134-139. Epub 2017 Oct 5.

Division of Pathology, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center Hospital East, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.lungcan.2017.10.001DOI Listing
November 2017

Fibroblast-led cancer cell invasion is activated by epithelial-mesenchymal transition through platelet-derived growth factor BB secretion of lung adenocarcinoma.

Cancer Lett 2017 06 9;395:20-30. Epub 2017 Mar 9.

Division of Pathology, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan; Laboratory of Cancer Biology, Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba, 277-8561, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2017.02.026DOI Listing
June 2017

Clinicopathological features of programmed death ligand 1 expression with tumor-infiltrating lymphocyte, mismatch repair, and Epstein-Barr virus status in a large cohort of gastric cancer patients.

Gastric Cancer 2017 May 14;20(3):407-415. Epub 2016 Sep 14.

Division of Pathology, Research Cancer for Innovative Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

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http://dx.doi.org/10.1007/s10120-016-0631-3DOI Listing
May 2017

Intraoperative peritoneal lavage cytology offers prognostic significance for gastric cancer patients with curative resection.

Cancer Sci 2017 May 22;108(5):978-986. Epub 2017 May 22.

Division of Pathology, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwa, Japan.

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http://doi.wiley.com/10.1111/cas.13219
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http://dx.doi.org/10.1111/cas.13219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5448654PMC
May 2017

The ratio of cancer cells to stroma after induction therapy in the treatment of non-small cell lung cancer.

J Cancer Res Clin Oncol 2017 Feb 17;143(2):215-223. Epub 2016 Sep 17.

Division of Pathology, Exploratory Oncology Research & Clinical Trial Center, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

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http://dx.doi.org/10.1007/s00432-016-2271-8DOI Listing
February 2017

Clinicopathological significance of caveolin-1 expression by cancer-associated fibroblasts in lung adenocarcinoma.

J Cancer Res Clin Oncol 2017 Feb 22;143(2):321-328. Epub 2016 Oct 22.

Division of Pathology, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

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http://dx.doi.org/10.1007/s00432-016-2285-2DOI Listing
February 2017

Bronchogenic cyst at esophagogastric junction treated by laparoscopic full-thickness resection and hand-sewn closure: a case report.

Surg Case Rep 2016 Dec 27;2(1):41. Epub 2016 Apr 27.

Gastric Surgery Division, National Cancer Centre Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

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http://dx.doi.org/10.1186/s40792-016-0168-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848280PMC
December 2016

The difference in Ezrin-pAkt signaling axis between lepidic and papillary predominant invasive adenocarcinomas of the lung.

J Cancer Res Clin Oncol 2016 Jul 8;142(7):1421-30. Epub 2016 Apr 8.

Division of Pathology, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

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http://dx.doi.org/10.1007/s00432-016-2154-zDOI Listing
July 2016

Interstitial growth as an aggressive growth pattern in primary lung cancer.

J Cancer Res Clin Oncol 2016 Jul 25;142(7):1591-8. Epub 2016 Apr 25.

Division of Pathology, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

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http://dx.doi.org/10.1007/s00432-016-2168-6DOI Listing
July 2016

The association of intravascular stromal cells with prognosis in high-grade neuroendocrine carcinoma of the lung.

J Cancer Res Clin Oncol 2016 May 22;142(5):905-12. Epub 2015 Dec 22.

Division of Pathology, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

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http://dx.doi.org/10.1007/s00432-015-2098-8DOI Listing
May 2016

Factors influencing the concordance of histological subtype diagnosis from biopsy and resected specimens of lung adenocarcinoma.

Lung Cancer 2016 Apr 22;94:1-6. Epub 2016 Jan 22.

Division of Pathology, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.lungcan.2016.01.009DOI Listing
April 2016

Unique intravascular tumor microenvironment predicting recurrence of lung squamous cell carcinoma.

J Cancer Res Clin Oncol 2016 Mar 31;142(3):593-600. Epub 2015 Oct 31.

Division of Pathology, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Chiba, 277-8577, Japan.

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http://dx.doi.org/10.1007/s00432-015-2068-1DOI Listing
March 2016

Cancer cell invasion driven by extracellular matrix remodeling is dependent on the properties of cancer-associated fibroblasts.

J Cancer Res Clin Oncol 2016 Feb 15;142(2):437-46. Epub 2015 Sep 15.

Division of Pathology, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, 6-5-1, Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

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http://link.springer.com/content/pdf/10.1007%2Fs00432-015-20
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http://link.springer.com/10.1007/s00432-015-2046-7
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http://dx.doi.org/10.1007/s00432-015-2046-7DOI Listing
February 2016

Gene copy number gain of EGFR is a poor prognostic biomarker in gastric cancer: evaluation of 855 patients with bright-field dual in situ hybridization (DISH) method.

Gastric Cancer 2016 Jan 9;19(1):63-73. Epub 2014 Dec 9.

Division of Pathology, Research Center for Innovative Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

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http://dx.doi.org/10.1007/s10120-014-0449-9DOI Listing
January 2016

TEM1 expression in cancer-associated fibroblasts is correlated with a poor prognosis in patients with gastric cancer.

Cancer Med 2015 Nov 4;4(11):1667-78. Epub 2015 Sep 4.

Pathology Division, Research Center for Innovative Oncology National Cancer Center at Kashiwa, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

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http://dx.doi.org/10.1002/cam4.515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673993PMC
November 2015

Podoplanin-expressing cancer-associated fibroblasts lead and enhance the local invasion of cancer cells in lung adenocarcinoma.

Int J Cancer 2015 Aug 20;137(4):784-96. Epub 2015 Feb 20.

Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.

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http://dx.doi.org/10.1002/ijc.29464DOI Listing
August 2015

A novel gene-protein assay for evaluating HER2 status in gastric cancer: simultaneous analyses of HER2 protein overexpression and gene amplification reveal intratumoral heterogeneity.

Gastric Cancer 2015 Jul 11;18(3):458-66. Epub 2014 Jun 11.

Pathology Division, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

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http://dx.doi.org/10.1007/s10120-014-0394-7DOI Listing
July 2015

Determination of the optimal cutoff percentage of residual tumors to define the pathological response rate for gastric cancer treated with preoperative therapy (JCOG1004-A).

Gastric Cancer 2015 Jul 27;18(3):597-604. Epub 2014 Jun 27.

JCOG Data Center/Operations Office, Multi-institutional Clinical Trial Support Center, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan,

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http://dx.doi.org/10.1007/s10120-014-0401-zDOI Listing
July 2015

Support system for pathologists and researchers.

J Pathol Inform 2015 23;6:34. Epub 2015 Jun 23.

Pathology Division, Cancer Center Hospital East, Chiba, Japan.

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http://dx.doi.org/10.4103/2153-3539.158911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485189PMC
July 2015

Expression profiles of HER2, EGFR, MET and FGFR2 in a large cohort of patients with gastric adenocarcinoma.

Gastric Cancer 2015 Apr 14;18(2):227-38. Epub 2014 Mar 14.

Division of Pathology, Research Center for Innovative Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa-city, Chiba, 277-8577, Japan.

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http://dx.doi.org/10.1007/s10120-014-0360-4DOI Listing
April 2015

Serum HER2 levels and HER2 status in tumor cells in advanced gastric cancer patients.

Jpn J Clin Oncol 2015 Jan 6;45(1):43-8. Epub 2014 Nov 6.

Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa.

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http://dx.doi.org/10.1093/jjco/hyu174DOI Listing
January 2015

High Mobility Group Box1 (HMGB1) released from cancer cells induces the expression of pro-inflammatory cytokines in peritoneal fibroblasts.

Pathol Int 2014 Jun;64(6):267-75

Laboratory of Cancer Biology, Department of Integrated Bioscience, Graduate School of Frontier Science, The University of Tokyo; Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.

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http://doi.wiley.com/10.1111/pin.12167
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http://dx.doi.org/10.1111/pin.12167DOI Listing
June 2014

Interpretation of HER2 tests in gastric cancer: confirmation of interobserver differences and validation of a QA/QC educational program.

Virchows Arch 2014 May 15;464(5):539-45. Epub 2014 Mar 15.

Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan,

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http://dx.doi.org/10.1007/s00428-014-1567-9DOI Listing
May 2014

Evaluation of HER2-based biology in 1,006 cases of gastric cancer in a Japanese population.

Gastric Cancer 2014 Jan 22;17(1):34-42. Epub 2013 Feb 22.

Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan,

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http://dx.doi.org/10.1007/s10120-013-0239-9DOI Listing
January 2014

Aldehyde dehydrogenase 1 expression in cancer cells could have prognostic value for patients with non-small cell lung cancer who are treated with neoadjuvant therapy: identification of prognostic microenvironmental factors after chemoradiation.

Pathol Int 2013 Dec;63(12):599-606

Division of Pathology, Research Center for Innovative Oncology, National Cancer Center, Hospital East, Kashiwa, Chiba, Japan; Division of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan; Juntendo University Graduate School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1111/pin.12122DOI Listing
December 2013

Transcriptional upregulation of HIF-1α by NF-κB/p65 and its associations with β-catenin/p300 complexes in endometrial carcinoma cells.

Lab Invest 2013 Nov 16;93(11):1184-93. Epub 2013 Sep 16.

Department of Pathology, Kitasato University School of Medicine, Sagamihara, Japan.

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http://dx.doi.org/10.1038/labinvest.2013.111DOI Listing
November 2013

Structure-based molecular simulations reveal the enhancement of biased Brownian motions in single-headed kinesin.

PLoS Comput Biol 2013 14;9(2):e1002907. Epub 2013 Feb 14.

Department of Biophysics Graduate School of Science, Kyoto University, Kyoto, Japan.

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http://dx.doi.org/10.1371/journal.pcbi.1002907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572960PMC
October 2013

Transcriptional regulation of the alpha-1 type II collagen gene by nuclear factor B/p65 and Sox9 in the chondrocytic phenotype of uterine carcinosarcomas.

Hum Pathol 2013 Sep 22;44(9):1780-8. Epub 2013 Apr 22.

Department of Pathology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa 252-0374, Japan.

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http://dx.doi.org/10.1016/j.humpath.2012.12.019DOI Listing
September 2013

Identification of intravascular tumor microenvironment features predicting the recurrence of pathological stage I lung adenocarcinoma.

Cancer Sci 2013 Sep 28;104(9):1262-9. Epub 2013 Jul 28.

Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Chiba, Japan.

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http://dx.doi.org/10.1111/cas.12219DOI Listing
September 2013

PTPRZ1 regulates calmodulin phosphorylation and tumor progression in small-cell lung carcinoma.

BMC Cancer 2012 Nov 21;12:537. Epub 2012 Nov 21.

Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

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http://dx.doi.org/10.1186/1471-2407-12-537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3577502PMC
November 2012

[Pathological evaluation and grading for neoadjuvant therapy].

Authors:
Takeshi Kuwata

Gan To Kagaku Ryoho 2012 Sep;39(9):1307-11

Dept. of Pathology and Clinical Laboratory, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.

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September 2012

Transcriptional up-regulation of Sox9 by NF-κB in endometrial carcinoma cells, modulating cell proliferation through alteration in the p14(ARF)/p53/p21(WAF1) pathway.

Am J Pathol 2012 Aug 12;181(2):684-92. Epub 2012 Jun 12.

Department of Pathology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.

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http://dx.doi.org/10.1016/j.ajpath.2012.05.008DOI Listing
August 2012

Morphophenotypic characteristics of intralymphatic cancer and stromal cells susceptible to lymphogenic metastasis.

Cancer Sci 2012 Jul 23;103(7):1342-7. Epub 2012 Apr 23.

Pathology Division, Research Center for Innovative Oncology, Chiba, Japan.

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http://dx.doi.org/10.1111/j.1349-7006.2012.02275.xDOI Listing
July 2012

Tumor promoting effect of podoplanin-positive fibroblasts is mediated by enhanced RhoA activity.

Biochem Biophys Res Commun 2012 May 7;422(1):194-9. Epub 2012 May 7.

Laboratory of Cancer Biology, Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2012.04.158DOI Listing
May 2012

Clinicopathological features of stomach cancer with invasive micropapillary component.

Gastric Cancer 2012 Apr 12;15(2):179-87. Epub 2011 Oct 12.

Division of Digestive Surgery, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba 277-8577, Japan.

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http://dx.doi.org/10.1007/s10120-011-0094-5DOI Listing
April 2012

Sox4 functions as a positive regulator of β-catenin signaling through upregulation of TCF4 during morular differentiation of endometrial carcinomas.

Lab Invest 2012 Apr 9;92(4):511-21. Epub 2012 Jan 9.

Department of Pathology, Kitasato University School of Medicine, Kanagawa, Japan.

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http://dx.doi.org/10.1038/labinvest.2011.196DOI Listing
April 2012

Pin1 acts as a modulator of cell proliferation through alteration in NF-κB but not β-catenin/TCF4 signalling in a subset of endometrial carcinoma cells.

J Pathol 2010 Dec;222(4):410-20

Department of Pathology, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara, Kanagawa 228-8555, Japan.

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http://doi.wiley.com/10.1002/path.2773
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December 2010

Stromal macrophage expressing CD204 is associated with tumor aggressiveness in lung adenocarcinoma.

J Thorac Oncol 2010 Oct;5(10):1507-15

Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.

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http://dx.doi.org/10.1097/JTO.0b013e3181eba692DOI Listing
October 2010

Transcriptional regulation of pro-apoptotic Par-4 by NF-kappaB/p65 and its function in controlling cell kinetics during early events in endometrial tumourigenesis.

J Pathol 2010 May;221(1):26-36

Department of Pathology, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara, Kanagawa 228-8555, Japan.

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http://doi.wiley.com/10.1002/path.2680
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May 2010

Requirement of the Akt/beta-catenin pathway for uterine carcinosarcoma genesis, modulating E-cadherin expression through the transactivation of slug.

Am J Pathol 2009 Jun 23;174(6):2107-15. Epub 2009 Apr 23.

Department of Pathology, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara, Kanagawa 228-8555, Japan.

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http://dx.doi.org/10.2353/ajpath.2009.081018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2684176PMC
June 2009

BCL11A is a SUMOylated protein and recruits SUMO-conjugation enzymes in its nuclear body.

Genes Cells 2008 Sep 4;13(9):931-40. Epub 2008 Aug 4.

Division of Carcinogenesis, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan.

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http://dx.doi.org/10.1111/j.1365-2443.2008.01216.xDOI Listing
September 2008

A functional role of Cdx2 in beta-catenin signaling during transdifferentiation in endometrial carcinomas.

Carcinogenesis 2007 Sep 29;28(9):1885-92. Epub 2007 Apr 29.

Department of Pathology, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara, Kanagawa 228-8555, Japan.

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http://dx.doi.org/10.1093/carcin/bgm105DOI Listing
September 2007

Trib1 and Evi1 cooperate with Hoxa and Meis1 in myeloid leukemogenesis.

Blood 2007 May 16;109(9):3998-4005. Epub 2007 Jan 16.

Department of Carcinogenesis, The Cancer Institute, Genome Center, Japanese Foundation for Cancer Research, 3-10-6 Ariake, Koto-ku, Tokyo 135-8550, Japan.

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http://dx.doi.org/10.1182/blood-2006-08-041202DOI Listing
May 2007

Upregulation of TCF4 expression as a transcriptional target of beta-catenin/p300 complexes during trans-differentiation of endometrial carcinoma cells.

Lab Invest 2005 Jun;85(6):768-79

Department of Pathology, Kitasato University School of Medicine, Kitasato, Sagamihara, Kanagawa, Japan.

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http://dx.doi.org/10.1038/labinvest.3700273DOI Listing
June 2005

Up-regulation and nuclear localization of beta-catenin in endometrial carcinoma in response to progesterone therapy.

Cancer Sci 2003 Jan;94(1):103-11

Department of Pathology, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara, Kanagawa 228-8555.

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http://dx.doi.org/10.1111/j.1349-7006.2003.tb01360.xDOI Listing
January 2003

Gamma interferon triggers interaction between ICSBP (IRF-8) and TEL, recruiting the histone deacetylase HDAC3 to the interferon-responsive element.

Mol Cell Biol 2002 Nov;22(21):7439-48

Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1128/mcb.22.21.7439-7448.2002DOI Listing
November 2002