Publications

Degradation of human Lipin-1 by BTRC E3 ubiquitin ligase.
Biochem Biophys Res Commun 2017 Jun 5;488(1):159-164. Epub 2017 May 5.
Laboratory of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan. Electronic address:


Biological implications of somatic DDX41 p.R525H mutation in acute myeloid leukemia.
Exp Hematol 2016 Aug 9;44(8):745-754.e4. Epub 2016 May 9.
Department of Molecular Oncology and Leukemia Program Project, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan; Department of Molecular Laboratory Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan; Central Clinical Laboratory, Kumamoto University Hospital, Kumamoto, Japan. Electronic address:

Thrombin-Activatable Fibrinolysis Inhibitor in Chronic Thromboembolic Pulmonary Hypertension.
Arterioscler Thromb Vasc Biol 2016 Jun 21;36(6):1293-301. Epub 2016 Apr 21.
From the Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan (N.Y., K. Satoh, T.S., K. Sugimura, S.T., S.Y., T.A., M.M., S.M., Y.F., H.S.), Clinical Pharmaceutics educational Center, Nihon Pharmaceutical University, Saitama, Japan (T.K.); and Department of Molecular and Cellular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan (H.H.).

PGE2 induced in and released by dying cells functions as an inhibitory DAMP.
Proc Natl Acad Sci U S A 2016 Apr 21;113(14):3844-9. Epub 2016 Mar 21.
Department of Molecular Immunology, Institute of Industrial Science, The University of Tokyo, Komaba 4-6-1, Meguro-ku, Tokyo 153-8505, Japan; Max Planck-The University of Tokyo Center for Integrative Inflammology, Komaba 4-6-1, Meguro-ku, Tokyo 153-8505, Japan;

Developments of mass spectrometry-based technologies for effective drug development linked with clinical proteomes.
Drug Metab Pharmacokinet 2016 Feb 17;31(1):3-11. Epub 2015 Dec 17.
Biosys Technologies, Inc., Meguro-ku, Tokyo, Japan; Department of Thoracic and Thyroid Surgery, Tokyo Medical University, Shinjuku-ku, Tokyo, Japan; Center of Excellence in Biological and Medical Mass Spectrometry, Lund University, BMC, Lund, Sweden.


An improvement on mass spectrometry-based epigenetic analysis of large histone-derived peptides by using the Ionization Variable Unit interface.
Anal Biochem 2015 Oct 5;486:14-6. Epub 2015 Jun 5.
Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, Meguro-Ku, Tokyo 153-8904, Japan. Electronic address:

Analysis of the subcellular localization of the human histone methyltransferase SETDB1.
Biochem Biophys Res Commun 2015 Oct 18;465(4):725-31. Epub 2015 Aug 18.
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan. Electronic address:

JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis.
Nat Commun 2015 May 7;6:7052. Epub 2015 May 7.
1] Division of Metabolic Medicine, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo, Tokyo 153-8904, Japan [2] The Translational Systems Biology and Medicine Initiative, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, University of Tokyo, Tokyo 113-8655, Japan.


The FBXL10/KDM2B scaffolding protein associates with novel polycomb repressive complex-1 to regulate adipogenesis.
J Biol Chem 2015 Feb 22;290(7):4163-77. Epub 2014 Dec 22.
From the Division of Metabolic Medicine, the Translational Systems Biology and Medicine Initiative Center for Disease Biology and Integrative Medicine, University of Tokyo, Tokyo 153-8904, Japan,

Middle-Down and Chemical Proteomic Approaches to Reveal Histone H4 Modification Dynamics in Cell Cycle: Label-Free Semi-Quantification of Histone Tail Peptide Modifications Including Phosphorylation and Highly Sensitive Capture of Histone PTM Binding Proteins Using Photo-Reactive Crosslinkers.
Mass Spectrom (Tokyo) 2015 14;4(1):A0039. Epub 2015 Jul 14.
Department of Systems Biology and Medicine, Research Center for Advanced Science and Technology, 
The University of Tokyo; The Translational Systems Biology and Medicine Initiative Center for Disease Biology and Integrative Medicine, 
Faculty of Medicine, University of Tokyo.

Clinical initiatives linking Japanese and Swedish healthcare resources on cancer studies utilizing Biobank Repositories.
Clin Transl Med 2014 Dec 22;3(1):61. Epub 2014 Nov 22.
First Department of Surgery, Tokyo Medical University, 6-7-1 Nishishinjuku Shinjuku-ku, Tokyo, 160-0023 Japan ; Clinical Protein Science & Imaging, Biomedical Center, Dept. of Biomedical Engineering, Lund University, BMC D13, 221 84 Lund, Sweden ; Center of Excellence in Biological and Medical mass spectrometry (CEBMMS), 221 84 Lund, Sweden.


MLL fusion proteins link transcriptional coactivators to previously active CpG-rich promoters.
Nucleic Acids Res 2014 Apr 23;42(7):4241-56. Epub 2014 Jan 23.
Laboratory for Malignancy Control Research, Medical Innovation Center, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan, Division of Hematological Malignancy, National Cancer Center Research Institute, Tokyo 104-0045, Japan, Department of Molecular Oncology and Leukemia Program Project, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734-8553, Japan and Department of Molecular Biology and Medicine, Laboratory for System Biology and Medicine (LSBM), Research Center for Advanced Science and Technology (RCAST), The University of Tokyo, Tokyo 153-8904, Japan.

Uhrf1-dependent H3K23 ubiquitylation couples maintenance DNA methylation and replication.
Nature 2013 Oct 8;502(7470):249-53. Epub 2013 Sep 8.
Department of Cell Biology, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467-8601, Japan.

The proteomic profile of circulating pentraxin 3 (PTX3) complex in sepsis demonstrates the interaction with azurocidin 1 and other components of neutrophil extracellular traps.
Mol Cell Proteomics 2012 Jun 25;11(6):M111.015073. Epub 2012 Jan 25.
Department of Molecular Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo 153-8904, Japan.









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