Takeshi Iwatsubo

Takeshi Iwatsubo

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Characterization of the unique In Vitro effects of unsaturated fatty acids on the formation of amyloid β fibrils.

PLoS One 2019 10;14(7):e0219465. Epub 2019 Jul 10.

Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0219465PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6619765PMC
July 2019

A Novel Method to Estimate Long-Term Chronological Changes From Fragmented Observations in Disease Progression.

Clin Pharmacol Ther 2019 Feb 20;105(2):436-447. Epub 2018 Aug 20.

Department of Pharmacy, Faculty of Medicine, The University of Tokyo Hospital, The University of Tokyo, Tokyo, Japan.

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http://doi.wiley.com/10.1002/cpt.1166
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http://dx.doi.org/10.1002/cpt.1166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617977PMC
February 2019

The past, present, and future of disease-modifying therapies for Alzheimer's disease.

Proc Jpn Acad Ser B Phys Biol Sci 2017 ;93(10):757-771

Unit for Early and Exploratory Clinical Development, the University of Tokyo Hospital.

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http://dx.doi.org/10.2183/pjab.93.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790756PMC
November 2018

Clinical and cognitive characteristics of preclinical Alzheimer's disease in the Japanese Alzheimer's Disease Neuroimaging Initiative cohort.

Alzheimers Dement (N Y) 2018 26;4:645-651. Epub 2018 Nov 26.

Unit for Early and Exploratory Clinical Development, The University of Tokyo Hospital, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.trci.2018.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258138PMC
November 2018

LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis.

Proc Natl Acad Sci U S A 2018 09 12;115(39):E9115-E9124. Epub 2018 Sep 12.

Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, 113-0033 Tokyo, Japan;

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http://dx.doi.org/10.1073/pnas.1812196115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166828PMC
September 2018

Self-assembly of FUS through its low-complexity domain contributes to neurodegeneration.

Hum Mol Genet 2018 04;27(8):1353-1365

Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan.

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http://dx.doi.org/10.1093/hmg/ddy046DOI Listing
April 2018

Sample Size Estimation for Alzheimer's Disease Trials from Japanese ADNI Serial Magnetic Resonance Imaging.

J Alzheimers Dis 2017 ;56(1):75-88

Integrative Brain Imaging Center (IBIC), National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan.

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http://dx.doi.org/10.3233/JAD-160621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240548PMC
February 2018

Extracellular α-synuclein levels are regulated by neuronal activity.

Mol Neurodegener 2018 02 22;13(1). Epub 2018 Feb 22.

Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.

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http://dx.doi.org/10.1186/s13024-018-0241-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822605PMC
February 2018

Parkinson's disease-associated mutant LRRK2 phosphorylates Rab7L1 and modifies trans-Golgi morphology.

Biochem Biophys Res Commun 2018 01 6;495(2):1708-1715. Epub 2017 Dec 6.

Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-0033, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2017.12.024DOI Listing
January 2018

Notable Drug-Drug Interaction Between Etizolam and Itraconazole in Poor Metabolizers of Cytochrome P450 2C19.

J Clin Pharmacol 2017 Nov 5;57(11):1491-1499. Epub 2017 Jul 5.

Department of Pharmacy, The University of Tokyo Hospital, Tokyo, Japan.

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http://dx.doi.org/10.1002/jcph.956DOI Listing
November 2017

[Toward Preclinical Trials for Alzheimer's Disease].

Brain Nerve 2017 Jul;69(7):711-722

Department of Neurology, The University of Tokyo Hospital.

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http://dx.doi.org/10.11477/mf.1416200812DOI Listing
July 2017

Phantom criteria for qualification of brain FDG and amyloid PET across different cameras.

EJNMMI Phys 2016 Dec 6;3(1):23. Epub 2016 Oct 6.

Division of Molecular Imaging, Institute of Biomedical Research and Innovation, 2-2, Minatojima-Minamimachi, Chuo-ku, Kobe, 650-0047, Japan.

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http://dx.doi.org/10.1186/s40658-016-0159-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052249PMC
December 2016

Partial loss of CALM function reduces Aβ42 production and amyloid deposition in vivo.

Hum Mol Genet 2016 09 27;25(18):3988-3997. Epub 2016 Jul 27.

Laboratory of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan

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http://dx.doi.org/10.1093/hmg/ddw239DOI Listing
September 2016

BIN1 regulates BACE1 intracellular trafficking and amyloid-β production.

Hum Mol Genet 2016 07 14;25(14):2948-2958. Epub 2016 May 14.

Laboratory of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences

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http://dx.doi.org/10.1093/hmg/ddw146DOI Listing
July 2016

LRRK2 and RAB7L1 coordinately regulate axonal morphology and lysosome integrity in diverse cellular contexts.

Sci Rep 2016 07 18;6:29945. Epub 2016 Jul 18.

Departments of Pathology, Cell Biology and Neurology, and Taub Institute, Columbia University, New York, NY, 10032, USA.

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http://dx.doi.org/10.1038/srep29945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947924PMC
July 2016

A novel non-canonical Notch signaling regulates expression of synaptic vesicle proteins in excitatory neurons.

Sci Rep 2016 Apr 4;6:23969. Epub 2016 Apr 4.

Laboratory of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan.

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http://dx.doi.org/10.1038/srep23969DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819173PMC
April 2016

Lack of correlation between the kinase activity of LRRK2 harboring kinase-modifying mutations and its phosphorylation at Ser910, 935, and Ser955.

PLoS One 2014 16;9(5):e97988. Epub 2014 May 16.

Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0097988PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024040PMC
August 2015

Role of Apolipoprotein E in β-Amyloidogenesis: ISOFORM-SPECIFIC EFFECTS ON PROTOFIBRIL TO FIBRIL CONVERSION OF Aβ IN VITRO AND BRAIN Aβ DEPOSITION IN VIVO.

J Biol Chem 2015 Jun 27;290(24):15163-74. Epub 2015 Apr 27.

From the Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences and the Department of Neuropathology, Graduate School of Medicine, University of Tokyo, Tokyo, 113-0033 Japan and

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http://dx.doi.org/10.1074/jbc.M114.622209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4463458PMC
June 2015

[Alzheimer disease: experimental approaches to genetic and environmental risk factors].

Rinsho Shinkeigaku 2013 ;53(11):956

Department of Neuropathology, School of Medicine, The University of Tokyo.

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http://dx.doi.org/10.5692/clinicalneurol.53.956DOI Listing
April 2015

[Current status and perspectives on the development of AD therapeutics based on amyloid cascade hypothesis].

Authors:
Takeshi Iwatsubo

Rinsho Shinkeigaku 2013 ;53(11):1039

Department of Neuropathology, School of Medicine, The University of Tokyo.

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http://dx.doi.org/10.5692/clinicalneurol.53.1039DOI Listing
April 2015

Synthetic ceramide analogues increase amyloid-β 42 production by modulating γ-secretase activity.

Biochem Biophys Res Commun 2015 Feb 27;457(2):194-9. Epub 2014 Dec 27.

Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X140227
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http://dx.doi.org/10.1016/j.bbrc.2014.12.087DOI Listing
February 2015

Cooperative roles of hydrophilic loop 1 and the C-terminus of presenilin 1 in the substrate-gating mechanism of γ-secretase.

J Neurosci 2015 Feb;35(6):2646-56

Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan,

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http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.3164-14.2
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http://dx.doi.org/10.1523/JNEUROSCI.3164-14.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6605612PMC
February 2015

Comprehensive phosphoproteome analysis unravels the core signaling network that initiates the earliest synapse pathology in preclinical Alzheimer's disease brain.

Hum Mol Genet 2015 Jan 17;24(2):540-58. Epub 2014 Sep 17.

Department of Neuropathology, Medical Research Institute and Center for Brain Integration Research, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8510, Japan

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http://hmg.oxfordjournals.org/content/24/2/540.full.pdf
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http://www.hmg.oxfordjournals.org/cgi/doi/10.1093/hmg/ddu475
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http://dx.doi.org/10.1093/hmg/ddu475DOI Listing
January 2015

Imago Mundi, Imago AD, Imago ADNI.

Alzheimers Res Ther 2014 29;6(5):62. Epub 2014 Aug 29.

Department of Neuropathology, School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku 113-0033, Tokyo, Japan.

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http://dx.doi.org/10.1186/s13195-014-0062-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255533PMC
December 2014

New photocleavable linker: α-thioacetophenone-type linker.

Bioorg Med Chem Lett 2014 Jul 9;24(13):2831-3. Epub 2014 May 9.

Graduate School of Pharmaceutical Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2014.04.104DOI Listing
July 2014

Allosteric regulation of γ-secretase activity by a phenylimidazole-type γ-secretase modulator.

Proc Natl Acad Sci U S A 2014 Jul 9;111(29):10544-9. Epub 2014 Jul 9.

Departments of Neuropathology and Neuroscience andFaculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan;Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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http://dx.doi.org/10.1073/pnas.1402171111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115564PMC
July 2014

Decreased CALM expression reduces Aβ42 to total Aβ ratio through clathrin-mediated endocytosis of γ-secretase.

Nat Commun 2014 Feb 28;5:3386. Epub 2014 Feb 28.

1] Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan [2] Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Tokyo 113-0033, Japan [3] Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.

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http://dx.doi.org/10.1038/ncomms4386DOI Listing
February 2014

Structural interactions between inhibitor and substrate docking sites give insight into mechanisms of human PS1 complexes.

Structure 2014 Jan 7;22(1):125-35. Epub 2013 Nov 7.

Department of Clinical Neurosciences, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK; Tanz Centre for Research in Neurodegenerative Diseases, and Departments of Medicine, Laboratory Medicine and Pathobiology, and Medical Biophysics, University of Toronto, Toronto, ON M5S 3H2, Canada. Electronic address:

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http://www.cell.com/structure/pdf/S0969-2126(13)00369-9.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S096921261300369
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http://dx.doi.org/10.1016/j.str.2013.09.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887256PMC
January 2014

Attenuation of the aggregation and neurotoxicity of amyloid-β peptides by catalytic photooxygenation.

Angew Chem Int Ed Engl 2014 Jan 11;53(5):1382-5. Epub 2013 Dec 11.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033 (Japan); Japan Science and Technology Agency (JST), ERATO, Kanai Life Science Catalysis Project, Bunkyo-ku, Tokyo 113-0033 (Japan).

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http://dx.doi.org/10.1002/anie.201308001DOI Listing
January 2014

Binding of longer Aβ to transmembrane domain 1 of presenilin 1 impacts on Aβ42 generation.

Mol Neurodegener 2014 Jan 13;9. Epub 2014 Jan 13.

Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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http://dx.doi.org/10.1186/1750-1326-9-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896738PMC
January 2014

Phase 3 trials of solanezumab for mild-to-moderate Alzheimer's disease.

N Engl J Med 2014 Jan;370(4):311-21

From the Alzheimer's Disease and Memory Disorders Center, Department of Neurology, Baylor College of Medicine, Houston (R.S.D.); Alzheimer's Disease Cooperative Study, Department of Family and Preventive Medicine (R.G.T., R.R., X.S.), and the Department of Neurosciences (R.G.T., R.R., P.S.A., R.M.), University of California at San Diego, San Diego; Indiana Alzheimer Disease Center, Indiana University (M.F.), and Eli Lilly (E.S., H.L.-S., R.M.) - both in Indianapolis; the Department of Neuropathology, School of Medicine, and the Department of Neuropathology and Neuroscience, School of Pharmacological Science, University of Tokyo, Tokyo (T.I.); Gerontopole, Unité Mixte de Recherche 1027, Centre Hospitalier Universitaire Toulouse, Toulouse, France (B.V.); the Department of Medical Ethics and Health Policy, University of Pennsylvania, Philadelphia (S.J.); and the Center for Human Experimental Therapeutics, University of Rochester Medical Center, Rochester, NY (K.K.).

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http://dx.doi.org/10.1056/NEJMoa1312889DOI Listing
January 2014

CLAC-P/collagen type XXV is required for the intramuscular innervation of motoneurons during neuromuscular development.

J Neurosci 2014 Jan;34(4):1370-9

Department of Neuropathology & Neuroscience, Graduate School of Pharmaceutical Sciences, and Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan, Institute for Molecular and Cellular Regulation, Gunma University, Gunma 371-8511, Japan, and Department of Cell Biology, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan.

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http://www.jneurosci.org/content/34/4/1370.full.pdf
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http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.2440-13.2
Publisher Site
http://dx.doi.org/10.1523/JNEUROSCI.2440-13.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6705307PMC
January 2014

[J-ADNI and very early treatment of Alzheimer's disease].

Authors:
Takeshi Iwatsubo

Nihon Ronen Igakkai Zasshi 2012 ;49(3):300-2

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http://dx.doi.org/10.3143/geriatrics.49.300DOI Listing
December 2013

FTY720/fingolimod, a sphingosine analogue, reduces amyloid-β production in neurons.

PLoS One 2013 7;8(5):e64050. Epub 2013 May 7.

Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0064050PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646787PMC
December 2013

Semagacestat for treatment of Alzheimer's disease.

N Engl J Med 2013 10;369(17):1661

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http://dx.doi.org/10.1056/NEJMc1310845DOI Listing
October 2013

Differential effects of familial parkinson mutations in LRRK2 revealed by a systematic analysis of autophosphorylation.

Biochemistry 2013 Sep 23;52(35):6052-62. Epub 2013 Aug 23.

Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo , 7-3-1 Hongo, Bunkyoku, Tokyo, 113-0033 Japan.

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http://dx.doi.org/10.1021/bi400596mDOI Listing
September 2013

Experimental detection of proteolytic activity in a signal peptide peptidase of Arabidopsis thaliana.

BMC Biochem 2013 Jul 6;14:16. Epub 2013 Jul 6.

Department of Applied Biological Chemistry, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1186/1471-2091-14-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710259PMC
July 2013

A phase 3 trial of semagacestat for treatment of Alzheimer's disease.

N Engl J Med 2013 Jul;369(4):341-50

Alzheimer's Disease and Memory Disorders Center, Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1056/NEJMoa1210951DOI Listing
July 2013

Comparison between brain CT and MRI for voxel-based morphometry of Alzheimer's disease.

Brain Behav 2013 Jul 30;3(4):487-93. Epub 2013 Jun 30.

Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, University of Tokyo Tokyo, Japan.

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http://dx.doi.org/10.1002/brb3.146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869687PMC
July 2013

Structural biology of presenilins and signal peptide peptidases.

J Biol Chem 2013 May 12;288(21):14673-80. Epub 2013 Apr 12.

Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan.

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http://dx.doi.org/10.1074/jbc.R113.463281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663492PMC
May 2013

Effect of helical conformation and side chain structure on γ-secretase inhibition by β-peptide foldamers: insight into substrate recognition.

J Med Chem 2013 Feb 6;56(4):1443-54. Epub 2013 Feb 6.

Department of Bioorganic-Inorganic Chemistry, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi, Japan.

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http://dx.doi.org/10.1021/jm301306cDOI Listing
February 2013

Inhibition of γ-secretase activity by a monoclonal antibody against the extracellular hydrophilic loop of presenilin 1.

Biochemistry 2013 Jan 14;52(1):61-9. Epub 2012 Dec 14.

Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan.

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http://pubs.acs.org/doi/10.1021/bi301252r
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http://dx.doi.org/10.1021/bi301252rDOI Listing
January 2013

Contribution of the γ-secretase subunits to the formation of catalytic pore of presenilin 1 protein.

J Biol Chem 2012 Jul 11;287(31):25834-43. Epub 2012 Jun 11.

Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1074/jbc.M111.336347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406669PMC
July 2012

Ku70 alleviates neurodegeneration in Drosophila models of Huntington's disease.

PLoS One 2011 7;6(11):e27408. Epub 2011 Nov 7.

Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0027408PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210167PMC
April 2012

Phosphorylation of α-synuclein protein at Ser-129 reduces neuronal dysfunction by lowering its membrane binding property in Caenorhabditis elegans.

J Biol Chem 2012 Mar 9;287(10):7098-109. Epub 2012 Jan 9.

Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.

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http://dx.doi.org/10.1074/jbc.M111.237131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293593PMC
March 2012

Re-examination of the dimerization state of leucine-rich repeat kinase 2: predominance of the monomeric form.

Biochem J 2012 Feb;441(3):987-94

Department of Neuropathology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyoku, Tokyo 113-0033, Japan.

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http://dx.doi.org/10.1042/BJ20111215DOI Listing
February 2012

Presenilins and γ-secretase: structure, function, and role in Alzheimer Disease.

Cold Spring Harb Perspect Med 2012 Jan;2(1):a006304

Center for Human Genetics, Leuven Institute for Neurodegenerative Diseases, KULeuven, 3000 Leuven, Belgium; Department of Molecular and Developmental Genetics, VIB, 3000, Leuven, Belgium.

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http://dx.doi.org/10.1101/cshperspect.a006304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253024PMC
January 2012

Comparison of presenilin 1 and presenilin 2 γ-secretase activities using a yeast reconstitution system.

J Biol Chem 2011 Dec 10;286(52):44569-75. Epub 2011 Nov 10.

Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, Tokyo 153-8902, Japan.

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http://dx.doi.org/10.1074/jbc.M111.270108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3247977PMC
December 2011

Phenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1.

EMBO J 2011 Oct 14;30(23):4815-24. Epub 2011 Oct 14.

Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1038/emboj.2011.372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3243616PMC
October 2011

[Alzheimer's disease Neuroimaging Initiative (ADNI)].

Authors:
Takeshi Iwatsubo

Nihon Rinsho 2011 Oct;69 Suppl 8:570-4

Department of Neuropathology, Graduate School of Medicine and Faculty of Medicine, the University of Tokyo.

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October 2011

[Molecular pathology and disease-modifying therapy of Alzheimer disease].

Authors:
Takeshi Iwatsubo

Seishin Shinkeigaku Zasshi 2011 ;113(6):568-73

Department of Neuropathology, School of Medicine, University of Tokyo.

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September 2011

Three-dimensional structure of the signal peptide peptidase.

J Biol Chem 2011 Jul 2;286(29):26188-97. Epub 2011 Jun 2.

Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan.

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http://dx.doi.org/10.1074/jbc.M111.260273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3138278PMC
July 2011

Efficient four-drug cocktail therapy targeting amyloid-β peptide for Alzheimer's disease.

J Neurosci Res 2010 Dec 1;88(16):3588-97. Epub 2010 Oct 1.

Department of Pharmacology, Faculty of Medicine, Saitama Medical University, Saitama, Japan.

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http://dx.doi.org/10.1002/jnr.22503DOI Listing
December 2010

Seeded aggregation and toxicity of {alpha}-synuclein and tau: cellular models of neurodegenerative diseases.

J Biol Chem 2010 Nov 30;285(45):34885-98. Epub 2010 Aug 30.

Department of Molecular Neurobiology, Tokyo Institute of Psychiatry, Tokyo 156-8585, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M110.148460
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http://dx.doi.org/10.1074/jbc.M110.148460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966103PMC
November 2010

Participation of transmembrane domain 1 of presenilin 1 in the catalytic pore structure of the γ-secretase.

J Neurosci 2010 Nov;30(47):15943-50

Department of Neuropathology and Neuroscience, The University of Tokyo, Tokyo 113-0033, Japan.

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http://dx.doi.org/10.1523/JNEUROSCI.3318-10.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6633739PMC
November 2010

[J-ADNI].

Authors:
Takeshi Iwatsubo

Rinsho Shinkeigaku 2010 Nov;50(11):935

Department of Neuropathology, School of Medicine, University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.5692/clinicalneurol.50.935DOI Listing
November 2010

[Molecular targeted therapy in Alzheimer disease].

Nihon Rinsho 2010 Oct;68(10):1906-10

Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo.

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October 2010

Novel Notch-sparing gamma-secretase inhibitors derived from a peroxisome proliferator-activated receptor agonist library.

Bioorg Med Chem Lett 2010 Sep 3;20(17):5282-5. Epub 2010 Jul 3.

Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Kita-ku, Okayama, Japan.

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http://dx.doi.org/10.1016/j.bmcl.2010.06.131DOI Listing
September 2010

Japanese Alzheimer's Disease Neuroimaging Initiative: present status and future.

Authors:
Takeshi Iwatsubo

Alzheimers Dement 2010 May;6(3):297-9

Department of Neuropathology, School of Medicine, University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.jalz.2010.03.011DOI Listing
May 2010

Development of photoaffinity probes for gamma-secretase equipped with a nitrobenzenesulfonamide-type cleavable linker.

Bioorg Med Chem Lett 2009 Dec 23;19(24):6869-71. Epub 2009 Oct 23.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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http://dx.doi.org/10.1016/j.bmcl.2009.10.086DOI Listing
December 2009

Identification of the autophosphorylation sites of LRRK2.

Biochemistry 2009 Nov;48(46):10963-75

Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyoku, Tokyo, 113-0033 Japan.

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http://dx.doi.org/10.1021/bi9011379DOI Listing
November 2009