Publications by authors named "Takehiro Yasukawa"

31Publications

Catalytically inactive Cas9 impairs DNA replication fork progression to induce focal genomic instability.

Nucleic Acids Res 2021 Jan 4. Epub 2021 Jan 4.

Department of Biochemistry, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

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January 2021

The accessory subunit of human DNA polymerase γ is required for mitochondrial DNA maintenance and is able to stabilize the catalytic subunit.

Mitochondrion 2020 07 26;53:133-139. Epub 2020 May 26.

Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka-shi, Fukuoka 812-8582, Japan.

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July 2020

Chemical acetylation of mitochondrial transcription factor A occurs on specific lysine residues and affects its ability to change global DNA topology.

Mitochondrion 2020 07 18;53:99-108. Epub 2020 May 18.

Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka-shi, Fukuoka 812-8582, Japan.

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July 2020

An overview of mammalian mitochondrial DNA replication mechanisms.

J Biochem 2018 Sep;164(3):183-193

Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Japan.

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September 2018

Accurate estimation of 5-methylcytosine in mammalian mitochondrial DNA.

Sci Rep 2018 04 11;8(1):5801. Epub 2018 Apr 11.

Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

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April 2018

Isolated and repeated stroke-like episodes in a middle-aged man with a mitochondrial ND3 T10158C mutation: a case report.

BMC Neurol 2017 Dec 13;17(1):217. Epub 2017 Dec 13.

Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

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December 2017

Cdk5rap1-mediated 2-methylthio-N6-isopentenyladenosine modification is absent from nuclear-derived RNA species.

Nucleic Acids Res 2017 Nov;45(20):11954-11961

Department of Molecular Physiology, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjyo, Kumamoto 860-8556, Japan.

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November 2017

Suppression of mitochondrial transcription initiation complexes changes the balance of replication intermediates of mitochondrial DNA and reduces 7S DNA in cultured human cells.

J Biochem 2016 Jul 8;160(1):49-57. Epub 2016 Feb 8.

Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

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July 2016

Increased negative supercoiling of mtDNA in TOP1mt knockout mice and presence of topoisomerases IIα and IIβ in vertebrate mitochondria.

Nucleic Acids Res 2014 Jun 6;42(11):7259-67. Epub 2014 May 6.

Laboratory of Molecular Pharmacology and Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4255, USA

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June 2014

Mitochondrial DNA replication proceeds via a 'bootlace' mechanism involving the incorporation of processed transcripts.

Nucleic Acids Res 2013 Jun 16;41(11):5837-50. Epub 2013 Apr 16.

MRC-Mitochondrial Biology Unit, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 0XY, UK.

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June 2013

Involvement of DNA ligase III and ribonuclease H1 in mitochondrial DNA replication in cultured human cells.

Biochim Biophys Acta 2011 Dec 22;1813(12):2000-7. Epub 2011 Aug 22.

The Wolfson Institute for Biomedical Research, University College London, Gower Street, London, UK.

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December 2011

Analysis of mitochondrial DNA by two-dimensional agarose gel electrophoresis.

Methods Mol Biol 2009 ;554:15-35

MRC Mitochondrial Biology Unit, Wellcome Trust/MRC Building, Cambridge, UK.

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October 2009

Analysis of replicating mitochondrial DNA by two-dimensional agarose gel electrophoresis.

Methods Mol Biol 2007 ;372:219-32

MRC Dunn Human Nutrition Unit, Wellcome Trust, Cambridge, United Kingdom.

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March 2008

The mitochondrial transcription termination factor mTERF modulates replication pausing in human mitochondrial DNA.

Nucleic Acids Res 2007 20;35(19):6458-74. Epub 2007 Sep 20.

Institute of Medical Technology and Tampere University Hospital, FI-33014, University of Tampere, Finland.

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December 2007

Acquisition of the wobble modification in mitochondrial tRNALeu(CUN) bearing the G12300A mutation suppresses the MELAS molecular defect.

Hum Mol Genet 2006 Mar 30;15(6):897-904. Epub 2006 Jan 30.

Department of Chemistry and Biotechnology, Graduate School of Engineering, Graduate School of Frontier Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.

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March 2006

[Overview of mammalian mitochondrial DNA replication and transcription].

Tanpakushitsu Kakusan Koso 2005 Nov;50(14 Suppl):1727-31

Medical Research Council, Dunn Human Nutrition Unit, Mitochondrial Diseases Group.

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November 2005

Wobble modification defect suppresses translational activity of tRNAs with MERRF and MELAS mutations.

Mitochondrion 2002 Nov;2(1-2):129-41

Department of Chemistry and Biotechnology, Graduate School of Engineering, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.

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November 2002

A bidirectional origin of replication maps to the major noncoding region of human mitochondrial DNA.

Mol Cell 2005 Jun;18(6):651-62

MRC-Dunn Human Nutrition Unit, Wellcome Trust-MRC Building, Hills Road, Cambridge CB2 2XY, United Kingdom.

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June 2005

Codon-specific translational defect caused by a wobble modification deficiency in mutant tRNA from a human mitochondrial disease.

Proc Natl Acad Sci U S A 2004 Oct 11;101(42):15070-5. Epub 2004 Oct 11.

Department of Chemistry and Biotechnology, Graduate School of Engineering, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.

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October 2004

The pathogenic A4269G mutation in human mitochondrial tRNA(Ile) alters the T-stem structure and decreases the binding affinity for elongation factor Tu.

Genes Cells 2004 Mar;9(3):243-52

Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa-shi, Chiba 277-8562, Japan.

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March 2004

Mammalian mitochondrial DNA replicates bidirectionally from an initiation zone.

J Biol Chem 2003 Dec 23;278(51):50961-9. Epub 2003 Sep 23.

Dunn Human Nutrition Unit, Wellcome Trust-Medical Research Council Building, Hills Road, Cambridge CB2 2XY, United Kingdom.

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December 2003

[Replication and repair of mitochondrial DNA].

Nihon Rinsho 2002 Apr;60 Suppl 4:24-9

Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo.

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April 2002

[Wobble modification defect suppresses translational activity of tRNAs with MERRF and MELAS mutations].

Nihon Rinsho 2002 Apr;60 Suppl 4:197-201

Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo.

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April 2002