Takeharu Hayashi

Takeharu Hayashi

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Takeharu Hayashi

Takeharu Hayashi

Publications by authors named "Takeharu Hayashi"

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Clinical and genetic backgrounds of hypertrophic cardiomyopathy with mid-ventricular obstruction.

J Hum Genet 2018 Dec 11;63(12):1273-1276. Epub 2018 Sep 11.

Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.

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http://dx.doi.org/10.1038/s10038-018-0509-9DOI Listing
December 2018

Genetic background of Japanese patients with pediatric hypertrophic and restrictive cardiomyopathy.

J Hum Genet 2018 Sep 15;63(9):989-996. Epub 2018 Jun 15.

Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.

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http://dx.doi.org/10.1038/s10038-018-0479-yDOI Listing
September 2018

Overexpression of heart-specific small subunit of myosin light chain phosphatase results in heart failure and conduction disturbance.

Am J Physiol Heart Circ Physiol 2018 06 16;314(6):H1192-H1202. Epub 2018 Feb 16.

Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University , Tokyo , Japan.

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http://dx.doi.org/10.1152/ajpheart.00696.2017DOI Listing
June 2018

Barth syndrome associated with triple mutation.

Pediatr Int 2018 Apr 6;60(4):385-387. Epub 2018 Mar 6.

Division of Neonatal Intensive Care, Nara Medical University, Nara, Japan.

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http://dx.doi.org/10.1111/ped.13517DOI Listing
April 2018

Phenotypic expression of a novel desmin gene mutation: hypertrophic cardiomyopathy followed by systemic myopathy.

J Hum Genet 2018 Feb 22;63(2):249-254. Epub 2017 Nov 22.

Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.

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http://dx.doi.org/10.1038/s10038-017-0383-xDOI Listing
February 2018

Screening of sarcomere gene mutations in young athletes with abnormal findings in electrocardiography: identification of a MYH7 mutation and MYBPC3 mutations.

J Hum Genet 2015 Oct 16;60(10):641-5. Epub 2015 Jul 16.

Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.

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http://dx.doi.org/10.1038/jhg.2015.81DOI Listing
October 2015

Delta-sarcoglycan gene therapy halts progression of cardiac dysfunction, improves respiratory failure, and prolongs life in myopathic hamsters.

Circ Heart Fail 2011 Jan 29;4(1):89-97. Epub 2010 Oct 29.

Center for Research in Biological Systems, the Department of Medicine, National Center for Microscopy and Imaging Research, University of California-San Diego, La Jolla, CA, USA.

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.110.957258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742303PMC
January 2011

Images in cardiovascular medicine. Bilateral rectus sheath hematoma developing during anticoagulant therapy.

Circulation 2010 Apr;121(15):1778-9

Department of Radiology, Nippon Koukan Hospital, Kawasaki, Japan.

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http://dx.doi.org/10.1161/CIR.0b013e3181db2135DOI Listing
April 2010

Impaired binding of ZASP/Cypher with phosphoglucomutase 1 is associated with dilated cardiomyopathy.

Cardiovasc Res 2009 Jul 17;83(1):80-8. Epub 2009 Apr 17.

Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Bunkyo-Ku, Tokyo, Japan.

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http://dx.doi.org/10.1093/cvr/cvp119DOI Listing
July 2009

Three-dimensional electron microscopy reveals new details of membrane systems for Ca2+ signaling in the heart.

J Cell Sci 2009 Apr;122(Pt 7):1005-13

The Center for Research in Biological Systems, University of California San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1242/jcs.028175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720931PMC
April 2009

Role of HCN4 channel in preventing ventricular arrhythmia.

J Hum Genet 2009 Feb 23;54(2):115-21. Epub 2009 Jan 23.

Department of Molecular Pathogenesis, Tokyo Medical and Dental University, Tokyo, Japan.

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http://dx.doi.org/10.1038/jhg.2008.16DOI Listing
February 2009

Structural analysis of obscurin gene in hypertrophic cardiomyopathy.

Biochem Biophys Res Commun 2007 Oct 13;362(2):281-7. Epub 2007 Aug 13.

Department of Molecular Pathogenesis, Medical Research Institute and Laboratory of Genome Diversity, School of Biomedical Science, Tokyo Medical and Dental University, 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo 101-0062, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2007.07.183DOI Listing
October 2007

Structural analysis of four and half LIM protein-2 in dilated cardiomyopathy.

Biochem Biophys Res Commun 2007 May 30;357(1):162-7. Epub 2007 Mar 30.

Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 101-0062, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2007.03.128DOI Listing
May 2007

Functional analysis of titin/connectin N2-B mutations found in cardiomyopathy.

J Muscle Res Cell Motil 2005 ;26(6-8):367-74

Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, 2-3-10 Kandasurugadai, Chiyoda-Ku, 101-0062, Tokyo , Japan.

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http://link.springer.com/content/pdf/10.1007/s10974-005-9018
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http://link.springer.com/10.1007/s10974-005-9018-5
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http://dx.doi.org/10.1007/s10974-005-9018-5DOI Listing
January 2007

Alpha B-crystallin mutation in dilated cardiomyopathy.

Biochem Biophys Res Commun 2006 Apr 8;342(2):379-86. Epub 2006 Feb 8.

Department of Molecular Pathogenesis, Medical Research Institute and Laboratory of Genome Diversity, School of Biomedical Science, Tokyo Medical and Dental University, Tokyo 101-0062, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2006.01.154DOI Listing
April 2006

Truncated KCNQ1 mutant, A178fs/105, forms hetero-multimer channel with wild-type causing a dominant-negative suppression due to trafficking defect.

FEBS Lett 2004 Sep;574(1-3):145-50

Department of Cardiovascular Diseases, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.

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http://dx.doi.org/10.1016/j.febslet.2004.08.018DOI Listing
September 2004

Functional characterization of a trafficking-defective HCN4 mutation, D553N, associated with cardiac arrhythmia.

J Biol Chem 2004 Jun 30;279(26):27194-8. Epub 2004 Apr 30.

Department of Molecular Pathogenesis, Medical Research Institute and Laboratory of Genome Diversity, School of Biomedical Science, Tokyo Medical and Dental University, Tokyo 101-0062, Japan.

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http://dx.doi.org/10.1074/jbc.M311953200DOI Listing
June 2004

A Cypher/ZASP mutation associated with dilated cardiomyopathy alters the binding affinity to protein kinase C.

J Biol Chem 2004 Feb 3;279(8):6746-52. Epub 2003 Dec 3.

Department of Molecular Pathogenesis, Medical Research Institute, and Laboratory of Genome Diversity, School of Biomedical Science, Tokyo Medical and Dental University, Tokyo 101-0062, Japan.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M311849200
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http://dx.doi.org/10.1074/jbc.M311849200DOI Listing
February 2004

Identification and functional analysis of a caveolin-3 mutation associated with familial hypertrophic cardiomyopathy.

Biochem Biophys Res Commun 2004 Jan;313(1):178-84

Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2003.11.101DOI Listing
January 2004

Association study of CD14 polymorphism with myocardial infarction in a Japanese population.

Jpn Heart J 2003 Sep;44(5):613-22

Department of Internal Medicine and Cardiology, Kitasato University School of Medicine, Kanagawa, Japan.

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http://dx.doi.org/10.1536/jhj.44.613DOI Listing
September 2003

Titin mutations as the molecular basis for dilated cardiomyopathy.

Biochem Biophys Res Commun 2002 Feb;291(2):385-93

Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo 101-0062, Japan.

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http://dx.doi.org/10.1006/bbrc.2002.6448DOI Listing
February 2002