Publications

Creation of a Claudin-2 Binder and Its Tight Junction-Modulating Activity in a Human Intestinal Model.
J Pharmacol Exp Ther 2017 Dec 19;363(3):444-451. Epub 2017 Sep 19.
Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan (Mu.T., M.I., S.N., A.W., Y.O., T.D., K.Y., J.K., M.K.); Laboratory of Vaccine Materials and Laboratory of Gut Environmental System, National Institute of Biomedical Innovation, Osaka, Japan (Mu.T., H.S., J.K.); Division of Biological Chemistry and Biologicals, National Institutes of Health Sciences, Tokyo, Japan (Mi.T.); Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases, Tokyo, Japan (M.F.); Graduate School of Medicine and Graduate School of Dentistry, Osaka University, Osaka, Japan (J.K.); Division of Mucosal Immunology, Department of Microbiology and Immunology and International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan (J.K.); and Department of Microbiology and Immunology, Kobe University Graduate School of Medicine, Hyogo, Japan (J.K.)

Claudin-5-Binders Enhance Permeation of Solutes across the Blood-Brain Barrier in a Mammalian Model.
J Pharmacol Exp Ther 2017 Nov 17;363(2):275-283. Epub 2017 Aug 17.
Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan (Y.H., K.S., Y.O., A.W., T.D., K.Y., M.K.); Proteo-Science Center, Ehime University, Ehime, Japan (H.T., T.S.); and Life Science Research Laboratories, Wako Pure Chemical Industries, Ltd., Hyogo, Japan (K.E., M.T., Y.S.)


Unbiased compound screening with a reporter gene assay highlights the role of p13 in the cardiac cellular stress response.
Biochem Biophys Res Commun 2017 Nov 24. Epub 2017 Nov 24.
Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan; Department of Biology, University of Padua, 35121 Padua, Italy. Electronic address:

Angubindin-1, a novel paracellular absorption enhancer acting at the tricellular tight junction.
J Control Release 2017 Aug 18;260:1-11. Epub 2017 May 18.
Graduate School of Pharmaceutical Sciences, Osaka University, Osaka 565-0871, Japan. Electronic address:

Adenovirus vector-based incorporation of a photo-cross-linkable amino acid into proteins in human primary cells and cancerous cell lines.
Sci Rep 2016 Nov 11;6:36946. Epub 2016 Nov 11.
Laboratory of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.


Expression of the Robo4 receptor in endothelial cells is regulated by two AP-1 protein complexes.
Biochem Biophys Res Commun 2015 Nov 14;467(4):987-91. Epub 2015 Oct 14.
Center for Vascular Biology Research and Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.

H3K4/H3K9me3 Bivalent Chromatin Domains Targeted by Lineage-Specific DNA Methylation Pauses Adipocyte Differentiation.
Mol Cell 2015 Nov;60(4):584-96
Division of Metabolic Medicine, The University of Tokyo, 4-6-1, Komaba, Meguro-ku, Tokyo 153-8904, Japan; The Translational Systems Biology and Medicine Initiative (TSBMI), Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, Tokyo 113-8655, Japan. Electronic address:

Analysis of the subcellular localization of the human histone methyltransferase SETDB1.
Biochem Biophys Res Commun 2015 Oct 18;465(4):725-31. Epub 2015 Aug 18.
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan. Electronic address:

Facilitation of adipocyte differentiation of 3T3-L1 cells by debrominated tetrabromobisphenol A compounds detected in Japanese breast milk.
Environ Res 2015 Jul 7;140:157-64. Epub 2015 Apr 7.
Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan. Electronic address:

WITHDRAWN: Loss of hepatic HIF-1α accelerates lipid accumulation by inhibiting peroxisomal fatty acid oxidation in nonalcoholic fatty liver disease.
J Hepatol 2015 Feb 10. Epub 2015 Feb 10.
Department of Life Sciences and Medical BioScience, Waseda University School of Advanced Science and Engineering, Tokyo, Japan. Electronic address:

Endothelial cell-specific expression of roundabout 4 is regulated by differential DNA methylation of the proximal promoter.
Arterioscler Thromb Vasc Biol 2014 Jul 22;34(7):1531-8. Epub 2014 May 22.
From the Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan (Y.O., N.F., T.T., Y.N., K.S., Y.K., H.N., A.S., M.S., J.Z., K.I., N.H., M.K., Y.M., S.N., T.D.); Center for Vascular Biology Research and Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (L.Y., W.C.A.); Department of Pathology, Center for Excellence in Vascular Biology, Harvard Medical School, Boston, MA (A.S.T., G.G.-C.); Department of Material Sciences, Massachusetts Institute of Technology, Boston (A.S.T.); and Stem Cell Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan (K.K.).


Selective evaluation of high density lipoprotein from mouse small intestine by an in situ perfusion technique.
J Lipid Res 2014 May 25;55(5):905-18. Epub 2014 Feb 25.
Laboratory of Cardiovascular Disease, Novel, Non-invasive and Nutritional Therapeutics (CNT), Graduate School of Medicine, Osaka University, Osaka, Japan.


An induced pluripotent stem cell-mediated and integration-free factor VIII expression system.
Biochem Biophys Res Commun 2013 Feb 3;431(2):336-41. Epub 2013 Jan 3.
Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, Tottori, Japan.




Sterol-mediated regulation of human lipin 1 gene expression in hepatoblastoma cells.
J Biol Chem 2009 Aug 24;284(33):22195-205. Epub 2009 Jun 24.
Graduate School of Pharmaceutical Sciences, Osaka University, Department of Molecular Pharmaceutical Science, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.


A GABP-binding element in the Robo4 promoter is necessary for endothelial expression in vivo.
Blood 2008 Sep 2;112(6):2336-9. Epub 2008 Jun 2.
Center for Vascular Biology Research and Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

Ligand-independent assembly of purified soluble magic roundabout (Robo4), a tumor-specific endothelial marker.
Protein Expr Purif 2008 Sep 21;61(1):78-82. Epub 2008 May 21.
Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.

A three-kilobase fragment of the human Robo4 promoter directs cell type-specific expression in endothelium.
Circ Res 2007 Jun 10;100(12):1712-22. Epub 2007 May 10.
Center for Vascular Biology Research and Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.


Identification of human low-density lipoprotein receptor as a novel target gene regulated by liver X receptor alpha.
FEBS Lett 2006 Sep 14;580(20):4929-33. Epub 2006 Aug 14.
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.








Degradation of human Lipin-1 by BTRC E3 ubiquitin ligase.
Biochem Biophys Res Commun 2017 06 5;488(1):159-164. Epub 2017 May 5.
Laboratory of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan. Electronic address:

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