Takayuki Sassa

Takayuki Sassa

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Takayuki Sassa

Takayuki Sassa

Publications by authors named "Takayuki Sassa"

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Severe Skin Permeability Barrier Dysfunction in Knockout Mice Deficient in a Fatty Acid ω-Hydroxylase Crucial to Acylceramide Production.

J Invest Dermatol 2019 Jul 26. Epub 2019 Jul 26.

Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2019.07.689DOI Listing
July 2019

De novo mutation in causes ichthyosis, , hypomyelination, spastic paraplegia, high frequency deafness and optic atrophy.

J Med Genet 2019 Mar 28;56(3):164-175. Epub 2018 Nov 28.

NeuroCure Clinical Research Center, Charité-Universitätsmedizin Berlin, Berlin, Germany.

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http://dx.doi.org/10.1136/jmedgenet-2018-105711DOI Listing
March 2019

Neural symptoms in a gene knockout mouse model of Sjögren-Larsson syndrome are associated with a decrease in 2-hydroxygalactosylceramide.

FASEB J 2019 01 7;33(1):928-941. Epub 2018 Aug 7.

Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan; and.

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http://dx.doi.org/10.1096/fj.201800291RDOI Listing
January 2019

Very long-chain tear film lipids produced by fatty acid elongase ELOVL1 prevent dry eye disease in mice.

FASEB J 2018 06 17;32(6):2966-2978. Epub 2018 Jan 17.

Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.

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http://dx.doi.org/10.1096/fj.201700947RDOI Listing
June 2018

Decreased Skin Barrier Lipid Acylceramide and Differentiation-Dependent Gene Expression in Ichthyosis Gene Nipal4-Knockout Mice.

J Invest Dermatol 2018 04 22;138(4):741-749. Epub 2017 Nov 22.

Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2017.11.008DOI Listing
April 2018

Cooperative Synthesis of Ultra Long-Chain Fatty Acid and Ceramide during Keratinocyte Differentiation.

PLoS One 2013 27;8(6):e67317. Epub 2013 Jun 27.

Laboratory of Biomembrane and Biofunctional Chemistry, Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0067317PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694974PMC
October 2017

Enzyme Activities of the Ceramide Synthases CERS2-6 Are Regulated by Phosphorylation in the C-terminal Region.

J Biol Chem 2016 Apr 17;291(14):7477-87. Epub 2016 Feb 17.

From the Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-ku, Sapporo 060-0812, Japan

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http://dx.doi.org/10.1074/jbc.M115.695858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817178PMC
April 2016

Lorenzo's oil inhibits ELOVL1 and lowers the level of sphingomyelin with a saturated very long-chain fatty acid.

J Lipid Res 2014 Mar 31;55(3):524-30. Epub 2014 Jan 31.

Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-ku, Sapporo 060-0812, Japan.

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http://dx.doi.org/10.1194/jlr.M044586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934736PMC
March 2014

Metabolism of very long-chain Fatty acids: genes and pathophysiology.

Biomol Ther (Seoul) 2014 Feb;22(2):83-92

Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-ku, Sapporo 060-0812, Japan.

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http://dx.doi.org/10.4062/biomolther.2014.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975470PMC
February 2014

Mutation for nonsyndromic mental retardation in the trans-2-enoyl-CoA reductase TER gene involved in fatty acid elongation impairs the enzyme activity and stability, leading to change in sphingolipid profile.

J Biol Chem 2013 Dec 12;288(51):36741-9. Epub 2013 Nov 12.

From the Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12-jo, Nishi 6-chome, Kita-ku, Sapporo 060-0812, Japan.

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http://dx.doi.org/10.1074/jbc.M113.493221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868783PMC
December 2013

The role of human-specific gene duplications during brain development and evolution.

Authors:
Takayuki Sassa

J Neurogenet 2013 Sep 20;27(3):86-96. Epub 2013 Jun 20.

Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.

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http://dx.doi.org/10.3109/01677063.2013.789512DOI Listing
September 2013

Transgenic zebrafish for ratiometric imaging of cytosolic and mitochondrial Ca2+ response in teleost embryo.

Cell Calcium 2013 Sep 30;54(3):236-45. Epub 2013 Jul 30.

Cell Function and Dynamics, Brain Science Institute, RIKEN, 2-1 Hirosawa, Wako-city, Saitama 351-0198, Japan.

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http://dx.doi.org/10.1016/j.ceca.2013.06.007DOI Listing
September 2013

A shift in sphingolipid composition from C24 to C16 increases susceptibility to apoptosis in HeLa cells.

Biochim Biophys Acta 2012 Jul 3;1821(7):1031-7. Epub 2012 May 3.

Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.

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http://dx.doi.org/10.1016/j.bbalip.2012.04.008DOI Listing
July 2012

Biochemical characterization of the very long-chain fatty acid elongase ELOVL7.

FEBS Lett 2011 Oct 22;585(20):3337-41. Epub 2011 Sep 22.

Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-ku, Sapporo, Japan.

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http://doi.wiley.com/10.1016/j.febslet.2011.09.024
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http://dx.doi.org/10.1016/j.febslet.2011.09.024DOI Listing
October 2011

Involvement of cyclin-dependent kinase-like 2 in cognitive function required for contextual and spatial learning in mice.

Front Behav Neurosci 2010 19;4:17. Epub 2010 Apr 19.

Laboratory of Molecular Endocrinology and Metabolism, Institute for Molecular and Cellular Regulation, Gunma University Maebashi, Japan.

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http://dx.doi.org/10.3389/fnbeh.2010.00017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2859807PMC
July 2011

ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis.

Proc Natl Acad Sci U S A 2010 Oct 11;107(43):18439-44. Epub 2010 Oct 11.

Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12-jo, Nishi 6-choume, Kita-ku, Sapporo 060-0812, Japan.

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http://dx.doi.org/10.1073/pnas.1005572107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2973002PMC
October 2010

The F-BAR domain of srGAP2 induces membrane protrusions required for neuronal migration and morphogenesis.

Cell 2009 Sep;138(5):990-1004

Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1016/j.cell.2009.06.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797480PMC
September 2009

Topography of thalamic projections requires attractive and repulsive functions of Netrin-1 in the ventral telencephalon.

PLoS Biol 2008 May;6(5):e116

Neuroscience Center, Department of Pharmacology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.0060116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2584572PMC
May 2008

Postnatal expression of Cdkl2 in mouse brain revealed by LacZ inserted into the Cdkl2 locus.

Cell Tissue Res 2004 Feb 7;315(2):147-56. Epub 2003 Nov 7.

Laboratory for Behavioral Genetics, Brain Science Institute, Riken, 2-1 Hirosawa, Wako, 351-0198 Saitama, Japan.

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http://link.springer.com/content/pdf/10.1007/s00441-003-0828
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http://link.springer.com/10.1007/s00441-003-0828-8
Publisher Site
http://dx.doi.org/10.1007/s00441-003-0828-8DOI Listing
February 2004